+F Repair protein KO
#
DNA Repair and Recombination Proteins - Contarinia nasturtii (swede midge)
%
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AEukaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D 116344869 uncharacterized protein LOC116344869 K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
D 116344363 activating signal cointegrator 1 complex subunit 3 K18663 ASCC3; activating signal cointegrator complex subunit 3 [EC:5.6.2.4]
D 116346499 deoxyribodipyrimidine photo-lyase K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]
C BER (base exicision repair)
D DNA glycosylases
E 116338580 single-strand selective monofunctional uracil DNA glycosylase K10800 SMUG1; single-strand selective monofunctional uracil DNA glycosylase [EC:3.2.2.-]
E 116339488 N-glycosylase/DNA lyase K03660 OGG1; N-glycosylase/DNA lyase [EC:3.2.2.- 4.2.99.18]
E 116341160 endonuclease III-like protein 1 isoform X1 K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
E 116337259 recombination repair protein 1 K10771 APEX1; AP endonuclease 1 [EC:3.1.11.2]
D Long Patch-BER factors
E DNA polymerase delta complex
F 116336821 DNA polymerase delta catalytic subunit K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
F 116337917 DNA polymerase delta small subunit isoform X1 K02328 POLD2; DNA polymerase delta subunit 2
F 116340491 DNA polymerase delta subunit 3 K03504 POLD3; DNA polymerase delta subunit 3
E DNA polymerase epsilon complex
F 116339303 DNA polymerase epsilon catalytic subunit 1 K02324 POLE; DNA polymerase epsilon subunit 1 [EC:2.7.7.7]
F 116344020 DNA polymerase epsilon subunit 2 K02325 POLE2; DNA polymerase epsilon subunit 2 [EC:2.7.7.7]
F 116346501 DNA polymerase epsilon subunit 3-like K02326 POLE3; DNA polymerase epsilon subunit 3 [EC:2.7.7.7]
F 116348410 DNA polymerase epsilon subunit 3-like K02326 POLE3; DNA polymerase epsilon subunit 3 [EC:2.7.7.7]
F 116345272 DNA polymerase epsilon subunit 4 isoform X1 K03506 POLE4; DNA polymerase epsilon subunit 4 [EC:2.7.7.7]
E 116348617 proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
E 116344452 flap endonuclease 1 K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
E 116342094 DNA ligase 1 isoform X1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
D Short Patch-BER factors
E 116342738 DNA repair protein XRCC1 K10803 XRCC1; DNA-repair protein XRCC1
D Other BER factors
E 116343976 probable tyrosyl-DNA phosphodiesterase K10862 TDP1; tyrosyl-DNA phosphodiesterase 1 [EC:3.1.4.-]
E 116338712 probable tyrosyl-DNA phosphodiesterase K10862 TDP1; tyrosyl-DNA phosphodiesterase 1 [EC:3.1.4.-]
E 116346450 probable tyrosyl-DNA phosphodiesterase K10862 TDP1; tyrosyl-DNA phosphodiesterase 1 [EC:3.1.4.-]
E 116343651 probable tyrosyl-DNA phosphodiesterase K10862 TDP1; tyrosyl-DNA phosphodiesterase 1 [EC:3.1.4.-]
E 116343672 aprataxin-like protein K10863 APTX; aprataxin [EC:3.6.1.70 3.6.1.71 3.6.1.72]
E 116337646 aprataxin and PNK-like factor K13295 APLF; aprataxin and PNK-like factor [EC:3.1.-.-]
E 116338707 uncharacterized protein F21D5.5 K08073 PNKP; bifunctional polynucleotide phosphatase/kinase [EC:3.1.3.32 2.7.1.78]
E 116344404 high mobility group protein DSP1 K10802 HMGB1; high mobility group protein B1
E 116343783 poly [ADP-ribose] polymerase-like K24070 PARP1; poly [ADP-ribose] polymerase 1 [EC:2.4.2.30]
E 116343869 poly [ADP-ribose] polymerase-like isoform X1 K24070 PARP1; poly [ADP-ribose] polymerase 1 [EC:2.4.2.30]
E 116343918 poly [ADP-ribose] polymerase-like K24070 PARP1; poly [ADP-ribose] polymerase 1 [EC:2.4.2.30]
E 116344189 poly [ADP-ribose] polymerase-like K24070 PARP1; poly [ADP-ribose] polymerase 1 [EC:2.4.2.30]
E 116344376 poly [ADP-ribose] polymerase-like K24070 PARP1; poly [ADP-ribose] polymerase 1 [EC:2.4.2.30]
E 116338695 poly [ADP-ribose] polymerase 1-like K24070 PARP1; poly [ADP-ribose] polymerase 1 [EC:2.4.2.30]
E 116346782 poly [ADP-ribose] polymerase-like K24070 PARP1; poly [ADP-ribose] polymerase 1 [EC:2.4.2.30]
E 116347929 poly [ADP-ribose] polymerase-like K24070 PARP1; poly [ADP-ribose] polymerase 1 [EC:2.4.2.30]
E 116341683 poly [ADP-ribose] polymerase-like K24070 PARP1; poly [ADP-ribose] polymerase 1 [EC:2.4.2.30]
E 116342549 poly [ADP-ribose] polymerase K24070 PARP1; poly [ADP-ribose] polymerase 1 [EC:2.4.2.30]
E 116350629 poly [ADP-ribose] polymerase-like K24070 PARP1; poly [ADP-ribose] polymerase 1 [EC:2.4.2.30]
E 116350630 poly [ADP-ribose] polymerase-like K24070 PARP1; poly [ADP-ribose] polymerase 1 [EC:2.4.2.30]
E 116343138 poly [ADP-ribose] polymerase-like K24070 PARP1; poly [ADP-ribose] polymerase 1 [EC:2.4.2.30]
E 116350940 poly [ADP-ribose] polymerase 1-like K24070 PARP1; poly [ADP-ribose] polymerase 1 [EC:2.4.2.30]
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E XPC-HR23B-CETN2 complex
F 116352445 DNA repair protein complementing XP-C cells homolog K10838 XPC; xeroderma pigmentosum group C-complementing protein
F 116337888 UV excision repair protein RAD23 homolog A K10839 RAD23; UV excision repair protein RAD23
E Cul4-DDB2 complex
F 116347560 RING-box protein 1A K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
F 116340052 cullin-4B K10609 CUL4; cullin 4
F 116344175 DNA damage-binding protein 1 isoform X1 K10610 DDB1; DNA damage-binding protein 1
E NER4 complex
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase II complex
F 116336729 DNA-directed RNA polymerase II subunit RPB1 K03006 RPB1; DNA-directed RNA polymerase II subunit RPB1 [EC:2.7.7.6]
F 116336885 DNA-directed RNA polymerase II subunit RPB2 K03010 RPB2; DNA-directed RNA polymerase II subunit RPB2 [EC:2.7.7.6]
F 116341444 DNA-directed RNA polymerase II subunit RPB2-like K03010 RPB2; DNA-directed RNA polymerase II subunit RPB2 [EC:2.7.7.6]
F 116347191 DNA-directed RNA polymerase II subunit RPB3 K03011 RPB3; DNA-directed RNA polymerase II subunit RPB3
F 116345574 transcriptional adapter 2A isoform X1 K03012 RPB4; DNA-directed RNA polymerase II subunit RPB4
F 116346193 DNA-directed RNA polymerase II subunit Rpb4-like K03012 RPB4; DNA-directed RNA polymerase II subunit RPB4
F 116344354 DNA-directed RNA polymerases I, II, and III subunit RPABC1 K03013 RPABC1; DNA-directed RNA polymerases I, II, and III subunit RPABC1
F 116338801 DNA-directed RNA polymerases I, II, and III subunit RPABC2 K03014 RPABC2; DNA-directed RNA polymerases I, II, and III subunit RPABC2
F 116350953 DNA-directed RNA polymerase II subunit RPB7 K03015 RPB7; DNA-directed RNA polymerase II subunit RPB7
F 116345789 DNA-directed RNA polymerases I, II, and III subunit RPABC3 K03016 RPABC3; DNA-directed RNA polymerases I, II, and III subunit RPABC3
F 116352289 DNA-directed RNA polymerase II subunit RPB9 K03017 RPB9; DNA-directed RNA polymerase II subunit RPB9
F 116348840 DNA-directed RNA polymerases I, II, and III subunit RPABC5 K03007 RPABC5; DNA-directed RNA polymerases I, II, and III subunit RPABC5
F 116342739 DNA-directed RNA polymerase II subunit RPB11 K03008 RPB11; DNA-directed RNA polymerase II subunit RPB11
F 116349460 DNA-directed RNA polymerases I, II, and III subunit RPABC4-like K03009 RPABC4; DNA-directed RNA polymerases I, II, and III subunit RPABC4
F 116351451 DNA-directed RNA polymerases I, II, and III subunit RPABC4-like K03009 RPABC4; DNA-directed RNA polymerases I, II, and III subunit RPABC4
F 116351459 DNA-directed RNA polymerases I, II, and III subunit RPABC4-like K03009 RPABC4; DNA-directed RNA polymerases I, II, and III subunit RPABC4
E Cul4-CSA complex
F 116347560 RING-box protein 1A K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
F 116340052 cullin-4B K10609 CUL4; cullin 4
F 116344175 DNA damage-binding protein 1 isoform X1 K10610 DDB1; DNA damage-binding protein 1
E Other TCR factor
F 116336914 transcription elongation factor 1 homolog K25829 ELOF1; transcription elongation factor 1
D TFIIH complex
E 116346076 general transcription and DNA repair factor IIH helicase subunit XPB K10843 ERCC3; DNA excision repair protein ERCC-3 [EC:5.6.2.4]
E 116339654 general transcription and DNA repair factor IIH helicase subunit XPD K10844 ERCC2; DNA excision repair protein ERCC-2 [EC:5.6.2.3]
E 116349376 general transcription factor IIH subunit 1 K03141 TFIIH1; transcription initiation factor TFIIH subunit 1
E 116337343 general transcription factor IIH subunit 2 K03142 TFIIH2; transcription initiation factor TFIIH subunit 2
E 116338312 general transcription factor IIH subunit 3 K03143 TFIIH3; transcription initiation factor TFIIH subunit 3
E 116343849 general transcription factor IIH subunit 4 K03144 TFIIH4; transcription initiation factor TFIIH subunit 4
E 116343863 general transcription factor IIH subunit 5 K10845 TTDA; TFIIH basal transcription factor complex TTD-A subunit
E 116350869 cyclin-dependent kinase 7 K02202 CDK7; cyclin-dependent kinase 7 [EC:2.7.11.22 2.7.11.23]
E 116351194 cyclin-dependent kinase 5 homolog K02202 CDK7; cyclin-dependent kinase 7 [EC:2.7.11.22 2.7.11.23]
E 116349607 cyclin-H K06634 CCNH; cyclin H
E 116338605 CDK-activating kinase assembly factor MAT1 K10842 MNAT1; CDK-activating kinase assembly factor MAT1
D RPA (replication factor A)
E 116346478 replication protein A 70 kDa DNA-binding subunit K07466 RFA1; replication factor A1
E 116338614 replication protein A 32 kDa subunit K10739 RFA2; replication factor A2
E 116341706 replication protein A 14 kDa subunit A K10740 RPA3; replication factor A3
D Other NER factors
E 116340154 DNA repair protein complementing XP-A cells homolog K10847 XPA; DNA-repair protein complementing XP-A cells
E 116344286 DNA excision repair protein ERCC-1 K10849 ERCC1; DNA excision repair protein ERCC-1
E 116350664 DNA repair endonuclease XPF K10848 ERCC4; DNA excision repair protein ERCC-4 [EC:3.1.-.-]
E 116340479 DNA repair protein complementing XP-G cells homolog K10846 ERCC5; DNA excision repair protein ERCC-5
E 116342094 DNA ligase 1 isoform X1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
E 116339790 MMS19 nucleotide excision repair protein homolog K15075 MET18; DNA repair/transcription protein MET18/MMS19
E 116340912 cullin-3 isoform X1 K03869 CUL3; cullin 3
E 116339661 cullin-5 K10612 CUL5; cullin 5
E 116341674 elongin-C K03872 ELOC; elongin-C
E 116347566 elongin-B isoform X1 K03873 ELOB; elongin-B
E 116338865 transcription elongation factor B polypeptide 3 K15076 ELOA; elongin-A
E 116348850 protein lingerer isoform X1 K26545 UBAP2; ubiquitin-associated protein 2
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
E 116343551 DNA mismatch repair protein spellchecker 1 K08735 MSH2; DNA mismatch repair protein MSH2
E 116350712 probable DNA mismatch repair protein Msh6 K08737 MSH6; DNA mismatch repair protein MSH6
D MutL homologs
E 116345932 DNA mismatch repair protein Mlh1 K08734 MLH1; DNA mismatch repair protein MLH1
E 116352219 mismatch repair endonuclease PMS2 K10858 PMS2; DNA mismatch repair protein PMS2
D DNA polymerase delta complex
E 116336821 DNA polymerase delta catalytic subunit K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
E 116337917 DNA polymerase delta small subunit isoform X1 K02328 POLD2; DNA polymerase delta subunit 2
E 116340491 DNA polymerase delta subunit 3 K03504 POLD3; DNA polymerase delta subunit 3
D RPA (replication factor A)
E 116346478 replication protein A 70 kDa DNA-binding subunit K07466 RFA1; replication factor A1
E 116338614 replication protein A 32 kDa subunit K10739 RFA2; replication factor A2
E 116341706 replication protein A 14 kDa subunit A K10740 RPA3; replication factor A3
D RFC (replication factor C)
E 116342789 replication factor C subunit 1 isoform X1 K10754 RFC1; replication factor C subunit 1
E 116342197 replication factor C subunit 2 K10755 RFC2_4; replication factor C subunit 2/4
E 116342803 replication factor C subunit 4 K10755 RFC2_4; replication factor C subunit 2/4
E 116344088 replication factor C subunit 5 K10756 RFC3_5; replication factor C subunit 3/5
E 116343195 replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
D Other MMR factors
E 116348617 proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
E 116341842 exonuclease 1 K10746 EXO1; exonuclease 1 [EC:3.1.-.-]
E 116344404 high mobility group protein DSP1 K10802 HMGB1; high mobility group protein B1
E 116342094 DNA ligase 1 isoform X1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D MRN(MRX) complex
E 116338850 double-strand break repair protein MRE11 K10865 MRE11; double-strand break repair protein MRE11
E 116339735 DNA repair protein RAD50 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
E 116350668 nibrin K10867 NBN; nibrin
D BRCA1-core complex
D BRCA1-A complex
D BRCA1-B complex
E 116348521 DNA topoisomerase 2-binding protein 1 K10728 TOPBP1; topoisomerase (DNA) II binding protein 1
D BRCA1-C complex
E 116338850 double-strand break repair protein MRE11 K10865 MRE11; double-strand break repair protein MRE11
E 116339735 DNA repair protein RAD50 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
E 116350668 nibrin K10867 NBN; nibrin
D BRCA complex
E 116344750 uncharacterized protein LOC116344750 K08775 BRCA2; breast cancer 2 susceptibility protein
E 116347634 DNA repair protein RAD51 homolog A K04482 RAD51; DNA repair protein RAD51
D RecA family proteins
E 116347634 DNA repair protein RAD51 homolog A K04482 RAD51; DNA repair protein RAD51
E 116348938 DNA repair protein RAD51 homolog 3 K10870 RAD51L2; RAD51-like protein 2
E 116337403 DNA repair protein RAD51 homolog 4 K10871 RAD51L3; RAD51-like protein 3
E 116337169 DNA repair protein XRCC2-like K10879 XRCC2; DNA-repair protein XRCC2
E 116352013 DNA repair protein XRCC3 homolog isoform X1 K10880 XRCC3; DNA-repair protein XRCC3
D Rad52 family proteins
D Rad54 family proteins
E 116338123 DNA repair and recombination protein RAD54-like K10875 RAD54L; DNA repair and recombination protein RAD54 and RAD54-like protein [EC:5.6.2.-]
D RecQ family DNA helicases
E 116338781 ATP-dependent DNA helicase Q1-like K10899 RECQL; ATP-dependent DNA helicase Q1 [EC:5.6.2.4]
E 116341847 Werner syndrome ATP-dependent helicase-like K10900 WRN; werner syndrome ATP-dependent helicase [EC:5.6.2.4]
E 116349312 Bloom syndrome protein homolog K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 116347020 ATP-dependent DNA helicase Q4 K10730 RECQL4; ATP-dependent DNA helicase Q4 [EC:5.6.2.4]
E 116342300 ATP-dependent DNA helicase Q-like 3 K10902 RECQL5; ATP-dependent DNA helicase Q5 [EC:5.6.2.4]
D Bloom's syndrome complex (BTR)
E 116349312 Bloom syndrome protein homolog K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 116341357 DNA topoisomerase 3-alpha isoform X1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 116349474 DNA topoisomerase 3-beta K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 116352341 recQ-mediated genome instability protein 1-like K10990 RMI1; RecQ-mediated genome instability protein 1
D RPA (replication factor A)
E 116346478 replication protein A 70 kDa DNA-binding subunit K07466 RFA1; replication factor A1
E 116338614 replication protein A 32 kDa subunit K10739 RFA2; replication factor A2
E 116341706 replication protein A 14 kDa subunit A K10740 RPA3; replication factor A3
D Protein phosphatase 4
E 116349210 serine/threonine-protein phosphatase 4 catalytic subunit K15423 PPP4C; serine/threonine-protein phosphatase 4 catalytic subunit [EC:3.1.3.16]
E 116347119 serine/threonine-protein phosphatase 4 regulatory subunit 1-like isoform X1 K15424 PPP4R1; serine/threonine-protein phosphatase 4 regulatory subunit 1
E 116342625 serine/threonine-protein phosphatase 4 regulatory subunit 2-like isoform X1 K15425 PPP4R2; serine/threonine-protein phosphatase 4 regulatory subunit 2
E 116336763 serine/threonine-protein phosphatase 4 regulatory subunit 3 isoform X1 K17491 SMEK; protein phosphatase 4 regulatory subunit 3
D AP-5 complex
D SMC5-SMC6 complex
E 116349089 structural maintenance of chromosomes protein 5 K22803 SMC5; structural maintenance of chromosomes protein 5
E 116347172 structural maintenance of chromosomes protein 6 K22804 SMC6; structural maintenance of chromosomes protein 6
E 116347926 non-structural maintenance of chromosomes element 1 homolog K22817 NSMCE1; non-structural maintenance of chromosomes element 1 [EC:2.3.2.27]
E 116342285 non-structural maintenance of chromosomes element 1 homolog K22817 NSMCE1; non-structural maintenance of chromosomes element 1 [EC:2.3.2.27]
E 116338159 non-structural maintenance of chromosomes element 3 homolog K22823 NSMCE3; non-structural maintenance of chromosomes element 3
E 116342343 EP300-interacting inhibitor of differentiation 3 K22825 NSMCE4; non-structural maintenance of chromosomes element 4
D Other HR factors
E 116337931 crossover junction endonuclease EME1 K10882 EME1; crossover junction endonuclease EME1 [EC:3.1.22.-]
E 116346857 uncharacterized protein LOC116346857 K20777 EXD2; exonuclease 3'-5' domain-containing protein 2 [EC:3.1.11.1]
E 116346858 exonuclease 3'-5' domain-containing protein 2-like K20777 EXD2; exonuclease 3'-5' domain-containing protein 2 [EC:3.1.11.1]
E 116349325 uncharacterized protein LOC116349325 K20777 EXD2; exonuclease 3'-5' domain-containing protein 2 [EC:3.1.11.1]
E 116342857 exonuclease 3'-5' domain-containing protein 2 K20777 EXD2; exonuclease 3'-5' domain-containing protein 2 [EC:3.1.11.1]
E 116341864 crossover junction endonuclease MUS81 K08991 MUS81; crossover junction endonuclease MUS81 [EC:3.1.22.-]
E 116348061 structure-specific endonuclease subunit SLX1 homolog isoform X1 K15078 SLX1; structure-specific endonuclease subunit SLX1 [EC:3.6.1.-]
E 116336683 flap endonuclease GEN K15338 GEN1; holliday junction resolvase GEN1/YEN1 [EC:3.1.-.-]
E 116346831 spatacsin K19026 SPG11; spatacsin
E 116339600 zinc finger FYVE domain-containing protein 26 homolog K19027 ZFYVE26; zinc finger FYVE domain-containing protein 26
E 116350338 mortality factor 4-like protein 1 K11339 MORF4L1; mortality factor 4-like protein 1
E 116341244 fidgetin-like protein 1 isoform X1 K22766 FIGNL1; fidgetin-like protein 1 [EC:5.6.2.-]
E 116337812 uncharacterized protein LOC116337812 K23112 BRAT1; BRCA1-associated ATM activator 1
E 116338913 uncharacterized protein LOC116338913 isoform X1 K23456 CFAP410; cilla- and flagella-associated protein
E 116340074 BRCA2-interacting transcriptional repressor EMSY-like K25790 EMSY; BRCA2-interacting transcriptional repressor EMSY
E 116345280 protein MMS22-like K26125 MMS22L; protein MMS22-like
E 116339349 tonsoku-like protein K09257 NFKBIL2; NF-kappa-B inhibitor-like protein 2
E 116337478 Werner Syndrome-like exonuclease K22807 WRNexo; werner syndrome-like exonuclease [EC:3.1.11.-]
C NHEJ (non-homologous end-joining)
D DNA-PK complex
E 116342290 X-ray repair cross-complementing protein 6 K10884 XRCC6; ATP-dependent DNA helicase 2 subunit 1
E 116346284 X-ray repair cross-complementing protein 5 K10885 XRCC5; ATP-dependent DNA helicase 2 subunit 2
E 116345983 DNA-dependent protein kinase catalytic subunit-like K06642 PRKDC; DNA-dependent protein kinase catalytic subunit [EC:2.7.11.1]
D MRX complex
E 116338850 double-strand break repair protein MRE11 K10865 MRE11; double-strand break repair protein MRE11
E 116339735 DNA repair protein RAD50 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
D DNA Ligase 4 complex
E 116343388 DNA ligase 4 K10777 LIG4; DNA ligase 4 [EC:6.5.1.1]
D X-family DNA polymerases
D Other NHEJ factors
E 116343672 aprataxin-like protein K10863 APTX; aprataxin [EC:3.6.1.70 3.6.1.71 3.6.1.72]
E 116337646 aprataxin and PNK-like factor K13295 APLF; aprataxin and PNK-like factor [EC:3.1.-.-]
E 116338474 protein artemis-like isoform X1 K10887 DCLRE1C; DNA cross-link repair 1C protein [EC:3.1.-.-]
C FA (Fanconi anemia) pathway
D FA core complex
E 116349134 E3 ubiquitin-protein ligase FANCL K10606 FANCL; E3 ubiquitin-protein ligase FANCL [EC:2.3.2.27]
E 116337712 ATP-dependent DNA helicase fml1 K10896 FANCM; fanconi anemia group M protein
D FA core complex binding factors
E 116351559 ubiquitin-conjugating enzyme E2 T-like K13960 UBE2T; ubiquitin-conjugating enzyme E2 T [EC:2.3.2.23]
D Bloom's syndrome complex (BTR)
E 116349312 Bloom syndrome protein homolog K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 116341357 DNA topoisomerase 3-alpha isoform X1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 116349474 DNA topoisomerase 3-beta K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 116352341 recQ-mediated genome instability protein 1-like K10990 RMI1; RecQ-mediated genome instability protein 1
D FANCD2-I complex
E 116339588 Fanconi anemia group D2 protein K10891 FANCD2; fanconi anemia group D2 protein
E 116336702 Fanconi anemia group I protein K10895 FANCI; fanconi anemia group I protein
D Downstream FA components
E 116344750 uncharacterized protein LOC116344750 K08775 BRCA2; breast cancer 2 susceptibility protein
D Other FA pathway factors
E 116347634 DNA repair protein RAD51 homolog A K04482 RAD51; DNA repair protein RAD51
E 116348938 DNA repair protein RAD51 homolog 3 K10870 RAD51L2; RAD51-like protein 2
E 116337520 ubiquitin carboxyl-terminal hydrolase 1 K11832 USP1; ubiquitin carboxyl-terminal hydrolase 1 [EC:3.4.19.12]
E 116338513 WD repeat-containing protein 48 homolog K15361 WDR48; WD repeat-containing protein 48
C Other DSBR factors
D Protein phosphatase 6
E 116349080 serine/threonine-protein phosphatase 6 catalytic subunit K15498 PPP6C; serine/threonine-protein phosphatase 6 catalytic subunit [EC:3.1.3.16]
E 116340092 serine/threonine-protein phosphatase 6 regulatory subunit 3-B K15501 PPP6R3; serine/threonine-protein phosphatase 6 regulatory subunit 3
D Ubiquitin ligases
E 116339874 probable E3 ubiquitin-protein ligase HERC2 K10595 HERC2; E3 ubiquitin-protein ligase HERC2 [EC:2.3.2.26]
D Others
E 116339777 telomerase Cajal body protein 1 homolog K23314 WRAP53; telomerase Cajal body protein 1
E 116339557 gastrulation defective protein 1 homolog K24752 WDR70; WD repeat-containing protein 70
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
D 116341973 DNA polymerase eta-like K03509 POLH; DNA polymerase eta [EC:2.7.7.7]
D 116342140 DNA polymerase eta K03509 POLH; DNA polymerase eta [EC:2.7.7.7]
D 116338771 DNA polymerase iota K03510 POLI; DNA polymerase iota [EC:2.7.7.7]
D 116347931 DNA repair protein REV1 K03515 REV1; DNA repair protein REV1 [EC:2.7.7.-]
C B-family DNA polymerases
D 116346925 DNA polymerase zeta catalytic subunit K02350 REV3L; DNA polymerase zeta [EC:2.7.7.7]
C A-family DNA polymerase
C Rad6 epistasis group
D 116343025 ubiquitin-conjugating enzyme E2-17 kDa K10573 UBE2A; ubiquitin-conjugating enzyme E2 A [EC:2.3.2.23]
D 116345840 ubiquitin-conjugating enzyme E2 variant 1 K10704 UBE2V; ubiquitin-conjugating enzyme E2 variant
D 116346452 ubiquitin-conjugating enzyme E2 N K10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23]
C Other TLS factors
D 116348617 proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
D 116340795 sprT-like domain-containing protein Spartan K24051 SPRTN; SprT-like domain-contaning protein Spartan
D 116343591 sprT-like domain-containing protein Spartan K24051 SPRTN; SprT-like domain-contaning protein Spartan
D 116340446 titin-like K26957 GCNA; germ cell nuclear acidic protein
B Check point factors
C Rad9-Hus1-Rad1 complex
D 116349156 cell cycle checkpoint control protein RAD9A K10994 RAD9A; cell cycle checkpoint control protein RAD9A [EC:3.1.11.2]
D 116340703 cell cycle checkpoint protein RAD1 K02830 HRAD1; cell cycle checkpoint protein [EC:3.1.11.2]
C HRAD17(Rad24)-RFC complex
D 116342033 cell cycle checkpoint protein RAD17 K06662 HRAD17; cell cycle checkpoint protein
D 116342197 replication factor C subunit 2 K10755 RFC2_4; replication factor C subunit 2/4
D 116342803 replication factor C subunit 4 K10755 RFC2_4; replication factor C subunit 2/4
D 116344088 replication factor C subunit 5 K10756 RFC3_5; replication factor C subunit 3/5
D 116343195 replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
C Rad17-Mec3-Ddc1 complex
D 116340703 cell cycle checkpoint protein RAD1 K02830 HRAD1; cell cycle checkpoint protein [EC:3.1.11.2]
C FPC (fork protection complex)
D 116345992 protein timeless homolog K10997 TIMELESS; replication fork protection complex subunit TIMELESS/Tof1/Swi1
D 116343256 protein TIPIN homolog K10998 TIPIN; replication fork protection complex subunit TIPIN/Csm3/Swi3
C Triple T complex
D 116349668 uncharacterized protein LOC116349668 K20403 TTI1; TELO2-interacting protein 1
C BAG6-UBL4A-GET4 complex
D 116338914 large proline-rich protein BAG6 isoform X1 K23390 BAG6; large proline-rich protein BAG6
D 116345247 ubiquitin-like protein 4A K23388 UBL4; ubiquitin-like protein 4
D 116348455 Golgi to ER traffic protein 4 homolog K23387 GET4; golgi to ER traffic protein 4
C Other check point factors
D 116337576 serine/threonine-protein kinase ATR K06640 ATR; serine/threonine-protein kinase ATR [EC:2.7.11.1]
D 116338418 serine/threonine-protein kinase ATM K04728 ATM; serine-protein kinase ATM [EC:2.7.11.1]
D 116338068 serine/threonine-protein kinase grp K02216 CHEK1; serine/threonine-protein kinase CHEK1 [EC:2.7.11.1]
D 116339187 ovarian-specific serine/threonine-protein kinase Lok-like K06641 CHEK2; serine/threonine-protein kinase CHEK2 [EC:2.7.11.1]
D 116341340 ovarian-specific serine/threonine-protein kinase Lok-like K06641 CHEK2; serine/threonine-protein kinase CHEK2 [EC:2.7.11.1]
D 116343718 ovarian-specific serine/threonine-protein kinase Lok-like K06641 CHEK2; serine/threonine-protein kinase CHEK2 [EC:2.7.11.1]
D 116337687 M-phase inducer phosphatase-like isoform X1 K05866 CDC25B; M-phase inducer phosphatase 2 [EC:3.1.3.48]
D 116338505 14-3-3 protein zeta isoform X1 K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
D 116339495 14-3-3 protein epsilon K06630 YWHAE; 14-3-3 protein epsilon
D 116337173 protein sickie isoform X1 K19483 NAV2; neuron navigator 2 [EC:5.6.2.4]
D 116343835 wee1-like protein kinase K06632 WEE1; wee1-like protein kinase [EC:2.7.11.1]
D 116339486 period circadian protein isoform X1 K02633 PER2; period circadian protein 2
D 116343839 plastin-2 isoform X1 K17336 PLS3; plastin-3
D 116338800 protein downstream neighbor of son homolog K22422 DONSON; protein downstream neighbor of Son
D 116345610 KN motif and ankyrin repeat domain-containing protein 4 isoform X1 K22808 KANK; KN motif and ankyrin repeat domain-containing protein
D 116343214 vacuolar protein sorting-associated protein 4B K12196 VPS4; vacuolar protein-sorting-associated protein 4
D 116337460 abscission/NoCut checkpoint regulator K24778 ZFYVE19; abscission/NoCut checkpoint regulator
D 116345211 replication stress response regulator SDE2 K25059 SDE2; replication stress response regulator SDE2
B Other factors with a suspected DNA repair function
C DNA polymerases
D 116339197 DNA polymerase theta isoform X1 K02349 POLQ; DNA polymerase theta [EC:2.7.7.7]
D 116349112 myb-binding protein 1A K02331 POL5; DNA polymerase phi [EC:2.7.7.7]
C Nucleases
D 116338548 three prime repair exonuclease 2-like K10791 TREX2; three prime repair exonuclease 2 [EC:3.1.11.2]
D 116348328 three prime repair exonuclease 2-like K10791 TREX2; three prime repair exonuclease 2 [EC:3.1.11.2]
D 116343223 uncharacterized protein LOC116343223 K15340 DCLRE1A; DNA cross-link repair 1A protein
D 116339901 uncharacterized protein LOC116339901 isoform X1 K15341 DCLRE1B; DNA cross-link repair 1B protein [EC:3.1.-.-]
D 116346378 ankyrin repeat and LEM domain-containing protein 1 K21411 ANKLE1; ankyrin repeat and LEM domain-containing protein 1
C Helicases
D 116344026 helicase POLQ-like K19178 HELQ; POLQ-like helicase [EC:5.6.2.4]
C PSO4 complex
D 116341237 pre-mRNA-processing factor 19 K10599 PRPF19; pre-mRNA-processing factor 19 [EC:2.3.2.27]
D 116340730 cell division cycle 5-like protein K12860 CDC5L; pre-mRNA-splicing factor CDC5/CEF1
D 116351148 pre-mRNA-splicing factor SPF27 K12861 BCAS2; pre-mRNA-splicing factor SPF27
D 116352370 pleiotropic regulator 1 K12862 PLRG1; pleiotropic regulator 1
C Modulation of nucleotide pools
D 116346687 8-oxo-dGDP phosphatase NUDT18 K17817 NUDT18; 8-oxo-dGDP phosphatase [EC:3.6.1.58]
D 116341068 deoxyuridine 5'-triphosphate nucleotidohydrolase K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 116342716 deoxyuridine 5'-triphosphate nucleotidohydrolase-like K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 116346412 ribonucleoside-diphosphate reductase large subunit-like K10807 RRM1; ribonucleoside-diphosphate reductase subunit M1 [EC:1.17.4.1]
D 116343628 ribonucleoside-diphosphate reductase large subunit-like K10807 RRM1; ribonucleoside-diphosphate reductase subunit M1 [EC:1.17.4.1]
D 116344903 ribonucleoside-diphosphate reductase subunit M2 B K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]
#
AProkaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D 116344869 uncharacterized protein LOC116344869 K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
D 116346499 deoxyribodipyrimidine photo-lyase K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]
C BER (base exicision repair)
D DNA glycosylases
E 116338580 single-strand selective monofunctional uracil DNA glycosylase K10800 SMUG1; single-strand selective monofunctional uracil DNA glycosylase [EC:3.2.2.-]
E 116341160 endonuclease III-like protein 1 isoform X1 K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
D RecJ
D DNA ligase
D DNA polymerase I
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase complex (RNAP)
E TRCF (transcription-repair coupling factor)
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
D Molecular matchmaker
D Strand discrimination factor
D DNA exonucleases
D DNA polymerase III holoenzyme
D DNA ligase
D Other MMR factors
E 116343832 uncharacterized protein LOC116343832 K03111 ssb; single-strand DNA-binding protein
E 116345154 uncharacterized protein LOC116345154 K03111 ssb; single-strand DNA-binding protein
E 116340868 uncharacterized protein LOC116340868 K03111 ssb; single-strand DNA-binding protein
E 116343512 single-stranded DNA-binding protein, mitochondrial K03111 ssb; single-strand DNA-binding protein
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D RecBC pathway proteins
D RecFOR pathway proteins
D AddAB pathway proteins
D Other HR factor
D Archaeal homologous recombinant proteins
C NHEJ (non-homologous end-joining)
D Two-component NHEJ DNA repair complex
D SHIIR (short-homology-independent illegitimate recombination)
E Facilitator
E Supressor
D SHDIR (short-homology-dependent illegitimate recombination)
E RecET pathway
E Facilitator
E Supressor
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
C Other SOS response factors
D 116343832 uncharacterized protein LOC116343832 K03111 ssb; single-strand DNA-binding protein
D 116345154 uncharacterized protein LOC116345154 K03111 ssb; single-strand DNA-binding protein
D 116340868 uncharacterized protein LOC116340868 K03111 ssb; single-strand DNA-binding protein
D 116343512 single-stranded DNA-binding protein, mitochondrial K03111 ssb; single-strand DNA-binding protein
B Other factors with a suspected DNA repair function
C DNA polymerase
C DNA helicases
C Modulation of nucleotide pools
D 116341068 deoxyuridine 5'-triphosphate nucleotidohydrolase K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 116342716 deoxyuridine 5'-triphosphate nucleotidohydrolase-like K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
C Others
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#
#[ BRITE | KEGG2 | KEGG ]
#Last updated: March 29, 2024