+F Repair protein KO
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DNA Repair and Recombination Proteins - Coprococcus sp. ART55/1
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AEukaryotic type
B SSBR (single strand breaks repair)
C Direct repair
C BER (base exicision repair)
D DNA glycosylases
E CCU_04990 Uracil-DNA glycosylase K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E CCU_15570 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase K03660 OGG1; N-glycosylase/DNA lyase [EC:3.2.2.- 4.2.99.18]
E CCU_08630 Predicted EndoIII-related endonuclease K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
D Long Patch-BER factors
E DNA polymerase delta complex
E DNA polymerase epsilon complex
D Short Patch-BER factors
D Other BER factors
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E XPC-HR23B-CETN2 complex
E Cul4-DDB2 complex
E NER4 complex
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase II complex
E Cul4-CSA complex
E Other TCR factor
D TFIIH complex
E CCU_11960 Rad3-related DNA helicases K10844 ERCC2; DNA excision repair protein ERCC-2 [EC:5.6.2.3]
D RPA (replication factor A)
D Other NER factors
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
D MutL homologs
D DNA polymerase delta complex
D RPA (replication factor A)
D RFC (replication factor C)
D Other MMR factors
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D MRN(MRX) complex
D BRCA1-core complex
D BRCA1-A complex
D BRCA1-B complex
D BRCA1-C complex
D BRCA complex
D RecA family proteins
D Rad52 family proteins
D Rad54 family proteins
D RecQ family DNA helicases
D Bloom's syndrome complex (BTR)
D RPA (replication factor A)
D Protein phosphatase 4
D AP-5 complex
D SMC5-SMC6 complex
D Other HR factors
C NHEJ (non-homologous end-joining)
D DNA-PK complex
D MRX complex
D DNA Ligase 4 complex
D X-family DNA polymerases
D Other NHEJ factors
C FA (Fanconi anemia) pathway
D FA core complex
D FA core complex binding factors
D Bloom's syndrome complex (BTR)
D FANCD2-I complex
D Downstream FA components
D Other FA pathway factors
C Other DSBR factors
D Protein phosphatase 6
D Ubiquitin ligases
D Others
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
C B-family DNA polymerases
C A-family DNA polymerase
C Rad6 epistasis group
C Other TLS factors
B Check point factors
C Rad9-Hus1-Rad1 complex
C HRAD17(Rad24)-RFC complex
C Rad17-Mec3-Ddc1 complex
C FPC (fork protection complex)
C Triple T complex
C BAG6-UBL4A-GET4 complex
C Other check point factors
B Other factors with a suspected DNA repair function
C DNA polymerases
C Nucleases
C Helicases
C PSO4 complex
C Modulation of nucleotide pools
D CCU_04890 ADP-ribose pyrophosphatase K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D CCU_14900 ADP-ribose pyrophosphatase K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D CCU_14150 ADP-ribose pyrophosphatase K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D CCU_12240 ADP-ribose pyrophosphatase K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D CCU_08950 deoxyuridine 5'-triphosphate nucleotidohydrolase K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
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AProkaryotic type
B SSBR (single strand breaks repair)
C Direct repair
C BER (base exicision repair)
D DNA glycosylases
E CCU_04990 Uracil-DNA glycosylase K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E CCU_08630 Predicted EndoIII-related endonuclease K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
D RecJ
E CCU_18140 exonuclease RecJ K07462 recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-]
D DNA ligase
E CCU_06330 DNA ligase, NAD-dependent K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
D DNA polymerase I
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E CCU_19150 excinuclease ABC, A subunit K03701 uvrA; excinuclease ABC subunit A
E CCU_19160 excinuclease ABC, B subunit K03702 uvrB; excinuclease ABC subunit B
E CCU_12750 Excinuclease ABC subunit C K03703 uvrC; excinuclease ABC subunit C
E CCU_12600 Superfamily I DNA and RNA helicases K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E CCU_08780 Superfamily I DNA and RNA helicases K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E CCU_06330 DNA ligase, NAD-dependent K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase complex (RNAP)
F CCU_16410 DNA-directed RNA polymerase, beta subunit/140 kD subunit K03043 rpoB; DNA-directed RNA polymerase subunit beta [EC:2.7.7.6]
F CCU_16390 DNA-directed RNA polymerase subunit beta' K03046 rpoC; DNA-directed RNA polymerase subunit beta' [EC:2.7.7.6]
F CCU_10460 DNA-directed RNA polymerase subunit alpha K03040 rpoA; DNA-directed RNA polymerase subunit alpha [EC:2.7.7.6]
F CCU_24500 DNA-directed RNA polymerase, omega subunit K03060 rpoZ; DNA-directed RNA polymerase subunit omega [EC:2.7.7.6]
E TRCF (transcription-repair coupling factor)
F CCU_08930 transcription-repair coupling factor K03723 mfd; transcription-repair coupling factor (superfamily II helicase) [EC:5.6.2.4]
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
E CCU_22670 Mismatch repair ATPase (MutS family) K03555 mutS; DNA mismatch repair protein MutS
E CCU_22430 MutS2 family protein K07456 mutS2; DNA mismatch repair protein MutS2
D Molecular matchmaker
E CCU_26360 DNA mismatch repair protein MutL K03572 mutL; DNA mismatch repair protein MutL
D Strand discrimination factor
D DNA exonucleases
E CCU_06930 Exonuclease VII small subunit. K03602 xseB; exodeoxyribonuclease VII small subunit [EC:3.1.11.6]
D DNA polymerase III holoenzyme
E CCU_02920 DNA polymerase III catalytic subunit, DnaE type K02337 dnaE; DNA polymerase III subunit alpha [EC:2.7.7.7]
E CCU_24790 DNA polymerase III catalytic subunit, PolC type K03763 polC; DNA polymerase III subunit alpha, Gram-positive type [EC:2.7.7.7]
E CCU_01600 DNA polymerase III, delta subunit K02340 holA; DNA polymerase III subunit delta [EC:2.7.7.7]
E CCU_18670 hypothetical protein K02341 holB; DNA polymerase III subunit delta' [EC:2.7.7.7]
E CCU_17610 DNA polymerase III, subunits gamma and tau K02343 dnaX; DNA polymerase III subunit gamma/tau [EC:2.7.7.7]
D DNA ligase
E CCU_06330 DNA ligase, NAD-dependent K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
D Other MMR factors
E CCU_12600 Superfamily I DNA and RNA helicases K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E CCU_08780 Superfamily I DNA and RNA helicases K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E CCU_03230 single-strand binding protein K03111 ssb; single-strand DNA-binding protein
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D RecBC pathway proteins
E CCU_25860 Holliday junction DNA helicase subunit RuvA K03550 ruvA; holliday junction DNA helicase RuvA
E CCU_24530 replication restart DNA helicase PriA K04066 priA; primosomal protein N' (replication factor Y) (superfamily II helicase) [EC:5.6.2.4]
E CCU_22770 ATPase involved in DNA repair K03546 sbcC; DNA repair protein SbcC/Rad50
E CCU_22760 exonuclease SbcD K03547 sbcD; DNA repair protein SbcD/Mre11
E CCU_00110 DNA repair exonuclease K03547 sbcD; DNA repair protein SbcD/Mre11
D RecFOR pathway proteins
E CCU_28940 DNA repair protein RadA K04485 radA; DNA repair protein RadA/Sms
E CCU_28700 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen K03655 recG; ATP-dependent DNA helicase RecG [EC:5.6.2.4]
E CCU_18140 exonuclease RecJ K07462 recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-]
E CCU_17590 recombination protein RecR K06187 recR; recombination protein RecR
E CCU_06870 DNA replication and repair protein RecN K03631 recN; DNA repair protein RecN (Recombination protein N)
E CCU_26140 Penicillin-binding protein-related factor A, putative recombinase K03700 recU; recombination protein U
E CCU_25860 Holliday junction DNA helicase subunit RuvA K03550 ruvA; holliday junction DNA helicase RuvA
D AddAB pathway proteins
E CCU_29150 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) K16898 addA; ATP-dependent helicase/nuclease subunit A [EC:5.6.2.4 3.1.-.-]
E CCU_29160 ATP-dependent nuclease, subunit B K16899 addB; ATP-dependent helicase/nuclease subunit B [EC:5.6.2.4 3.1.-.-]
D Other HR factor
D Archaeal homologous recombinant proteins
E CCU_22770 ATPase involved in DNA repair K03546 sbcC; DNA repair protein SbcC/Rad50
E CCU_22760 exonuclease SbcD K03547 sbcD; DNA repair protein SbcD/Mre11
E CCU_00110 DNA repair exonuclease K03547 sbcD; DNA repair protein SbcD/Mre11
C NHEJ (non-homologous end-joining)
D Two-component NHEJ DNA repair complex
D SHIIR (short-homology-independent illegitimate recombination)
E Facilitator
F CCU_19530 DNA gyrase subunit A K02469 gyrA; DNA gyrase subunit A [EC:5.6.2.2]
F CCU_25160 Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit K02469 gyrA; DNA gyrase subunit A [EC:5.6.2.2]
F CCU_19520 DNA gyrase subunit B K02470 gyrB; DNA gyrase subunit B [EC:5.6.2.2]
F CCU_06500 DNA topoisomerase I K03168 topA; DNA topoisomerase I [EC:5.6.2.1]
E Supressor
F CCU_21770 Bacterial nucleoid DNA-binding protein K03530 hupB; DNA-binding protein HU-beta
D SHDIR (short-homology-dependent illegitimate recombination)
E RecET pathway
F CCU_18140 exonuclease RecJ K07462 recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-]
F CCU_17590 recombination protein RecR K06187 recR; recombination protein RecR
F CCU_06330 DNA ligase, NAD-dependent K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
E Facilitator
E Supressor
F CCU_19150 excinuclease ABC, A subunit K03701 uvrA; excinuclease ABC subunit A
F CCU_19160 excinuclease ABC, B subunit K03702 uvrB; excinuclease ABC subunit B
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
C Other SOS response factors
D CCU_06870 DNA replication and repair protein RecN K03631 recN; DNA repair protein RecN (Recombination protein N)
D CCU_03230 single-strand binding protein K03111 ssb; single-strand DNA-binding protein
D CCU_09860 hypothetical protein K14623 dinD; DNA-damage-inducible protein D
B Other factors with a suspected DNA repair function
C DNA polymerase
C DNA helicases
D CCU_04790 Rad3-related DNA helicases K03722 dinG; ATP-dependent DNA helicase DinG [EC:5.6.2.3]
C Modulation of nucleotide pools
D CCU_04890 ADP-ribose pyrophosphatase K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D CCU_14900 ADP-ribose pyrophosphatase K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D CCU_14150 ADP-ribose pyrophosphatase K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D CCU_12240 ADP-ribose pyrophosphatase K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D CCU_08950 deoxyuridine 5'-triphosphate nucleotidohydrolase K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
C Others
D CCU_24890 Exopolyphosphatase-related proteins K06881 nrnA; bifunctional oligoribonuclease and PAP phosphatase NrnA [EC:3.1.3.7 3.1.13.3]
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: March 29, 2024