+F Repair protein KO
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DNA Repair and Recombination Proteins - Chiloscyllium plagiosum (whitespotted bambooshark)
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AEukaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D 122562561 alkbh2; DNA oxidative demethylase ALKBH2 K10859 ALKBH2; DNA oxidative demethylase [EC:1.14.11.33]
D 122557662 alkbh3; alpha-ketoglutarate-dependent dioxygenase alkB homolog 3 K10860 ALKBH3; mRNA N1-methyladenine demethylase [EC:1.14.11.54]
D 122548403 ascc3; activating signal cointegrator 1 complex subunit 3 isoform X1 K18663 ASCC3; activating signal cointegrator complex subunit 3 [EC:5.6.2.4]
D 122556033 CPD photolyase K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]
C BER (base exicision repair)
D DNA glycosylases
E 122562560 unga; uracil DNA glycosylase a K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E 122555558 cyclin-O K10861 UDG2; uracil-DNA glycosylase 2 [EC:3.2.2.-]
E 122559835 G/T mismatch-specific thymine DNA glycosylase-like isoform X1 K20813 TDG; thymine-DNA glycosylase [EC:3.2.2.29]
E 122548640 mpg; DNA-3-methyladenine glycosylase K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]
E 122554299 mutyh; adenine DNA glycosylase isoform X1 K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
E 122559122 mbd4; methyl-CpG-binding domain protein 4 isoform X1 K10801 MBD4; methyl-CpG-binding domain protein 4 [EC:3.2.2.-]
E 122558885 ogg1; N-glycosylase/DNA lyase K03660 OGG1; N-glycosylase/DNA lyase [EC:3.2.2.- 4.2.99.18]
E 122542633 neil1; endonuclease 8-like 1 isoform X1 K10567 NEIL1; endonuclease VIII-like 1 [EC:3.2.2.- 4.2.99.18]
E 122553188 endonuclease 8-like 2 K10568 NEIL2; endonuclease VIII-like 2 [EC:3.2.2.- 4.2.99.18]
E 122557301 neil3; endonuclease 8-like 3 isoform X1 K10569 NEIL3; endonuclease VIII-like 3 [EC:3.2.2.- 4.2.99.18]
E 122560515 nthl1; endonuclease III-like protein 1 isoform X1 K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
E 122540168 apex2; DNA-(apurinic or apyrimidinic site) lyase 2 isoform X1 K10772 APEX2; AP endonuclease 2 [EC:3.1.11.2]
D Long Patch-BER factors
E DNA polymerase delta complex
F 122542199 pold1; DNA polymerase delta catalytic subunit K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
F 122543102 pold2; DNA polymerase delta subunit 2 K02328 POLD2; DNA polymerase delta subunit 2
F 122550977 pold3; DNA polymerase delta subunit 3 isoform X1 K03504 POLD3; DNA polymerase delta subunit 3
F 122546911 pold4; DNA polymerase delta subunit 4 K03505 POLD4; DNA polymerase delta subunit 4
E DNA polymerase epsilon complex
F 122562599 pole; DNA polymerase epsilon catalytic subunit A K02324 POLE; DNA polymerase epsilon subunit 1 [EC:2.7.7.7]
F 122553503 pole2; DNA polymerase epsilon subunit 2 K02325 POLE2; DNA polymerase epsilon subunit 2 [EC:2.7.7.7]
F 122564739 pole3; DNA polymerase epsilon subunit 3 K02326 POLE3; DNA polymerase epsilon subunit 3 [EC:2.7.7.7]
F 122565283 pole4; DNA polymerase epsilon subunit 4 isoform X1 K03506 POLE4; DNA polymerase epsilon subunit 4 [EC:2.7.7.7]
E 122543049 pcna; proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
D Short Patch-BER factors
E 122543169 polb; DNA polymerase beta isoform X1 K02330 POLB; DNA polymerase beta [EC:2.7.7.7 4.2.99.-]
E 122564126 lig3; DNA ligase 3 isoform X1 K10776 LIG3; DNA ligase 3 [EC:6.5.1.1]
D Other BER factors
E 122553360 tdp1; tyrosyl-DNA phosphodiesterase 1 isoform X1 K10862 TDP1; tyrosyl-DNA phosphodiesterase 1 [EC:3.1.4.-]
E 122563017 aptx; aprataxin K10863 APTX; aprataxin [EC:3.6.1.70 3.6.1.71 3.6.1.72]
E 122553108 aplf; aprataxin and PNK-like factor K13295 APLF; aprataxin and PNK-like factor [EC:3.1.-.-]
E 122561277 poll; DNA polymerase lambda isoform X1 K03512 POLL; DNA polymerase lambda [EC:2.7.7.7 4.2.99.-]
E 122548525 parp1; poly [ADP-ribose] polymerase 1 K24070 PARP1; poly [ADP-ribose] polymerase 1 [EC:2.4.2.30]
E 122550726 parp4; protein mono-ADP-ribosyltransferase PARP4 isoform X1 K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
E 122559136 parp3; protein mono-ADP-ribosyltransferase PARP3 K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E XPC-HR23B-CETN2 complex
F 122558784 xpc; DNA repair protein complementing XP-C cells isoform X1 K10838 XPC; xeroderma pigmentosum group C-complementing protein
F 122565130 UV excision repair protein RAD23 homolog B-like isoform X1 K10839 RAD23; UV excision repair protein RAD23
F 122552369 UV excision repair protein RAD23 homolog A-like K10839 RAD23; UV excision repair protein RAD23
F 122557197 caltractin-like K10840 CETN2; centrin-2
E Cul4-DDB2 complex
F 122542300 rbx1; E3 ubiquitin-protein ligase RBX1 K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
F 122554895 cullin-4A-like isoform X1 K10609 CUL4; cullin 4
F 122557283 cul4b; cullin-4B isoform X1 K10609 CUL4; cullin 4
F 122545262 DNA damage-binding protein 1-like K10610 DDB1; DNA damage-binding protein 1
F 122557892 ddb1; DNA damage-binding protein 1 isoform X1 K10610 DDB1; DNA damage-binding protein 1
E NER4 complex
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase II complex
F 122548219 polr2a; DNA-directed RNA polymerase II subunit RPB1 isoform X1 K03006 RPB1; DNA-directed RNA polymerase II subunit RPB1 [EC:2.7.7.6]
F 122539431 polr2b; DNA-directed RNA polymerase II subunit RPB2 isoform X1 K03010 RPB2; DNA-directed RNA polymerase II subunit RPB2 [EC:2.7.7.6]
F 122558624 polr2c; DNA-directed RNA polymerase II subunit RPB3 K03011 RPB3; DNA-directed RNA polymerase II subunit RPB3
F 122555721 polr2d; DNA-directed RNA polymerase II subunit RPB4 K03012 RPB4; DNA-directed RNA polymerase II subunit RPB4
F 122565352 DNA-directed RNA polymerases I, II, and III subunit RPABC1 K03013 RPABC1; DNA-directed RNA polymerases I, II, and III subunit RPABC1
F 122542109 polr2f; DNA-directed RNA polymerases I, II, and III subunit RPABC2 isoform X1 K03014 RPABC2; DNA-directed RNA polymerases I, II, and III subunit RPABC2
F 122543820 polr2g; DNA-directed RNA polymerase II subunit RPB7 K03015 RPB7; DNA-directed RNA polymerase II subunit RPB7
F 122555954 polr2h; DNA-directed RNA polymerases I, II, and III subunit RPABC3 isoform X1 K03016 RPABC3; DNA-directed RNA polymerases I, II, and III subunit RPABC3
F 122542803 polr2i; DNA-directed RNA polymerase II subunit RPB9 isoform X1 K03017 RPB9; DNA-directed RNA polymerase II subunit RPB9
F 122542128 polr2l; DNA-directed RNA polymerases I, II, and III subunit RPABC5 K03007 RPABC5; DNA-directed RNA polymerases I, II, and III subunit RPABC5
F 122547561 polr2j; DNA-directed RNA polymerase II subunit RPB11-a K03008 RPB11; DNA-directed RNA polymerase II subunit RPB11
F 122549147 polr2k; DNA-directed RNA polymerases I, II, and III subunit RPABC4 K03009 RPABC4; DNA-directed RNA polymerases I, II, and III subunit RPABC4
F 122557520 DNA-directed RNA polymerases I, II, and III subunit RPABC4-like K03009 RPABC4; DNA-directed RNA polymerases I, II, and III subunit RPABC4
E Cul4-CSA complex
F 122542300 rbx1; E3 ubiquitin-protein ligase RBX1 K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
F 122554895 cullin-4A-like isoform X1 K10609 CUL4; cullin 4
F 122557283 cul4b; cullin-4B isoform X1 K10609 CUL4; cullin 4
F 122545262 DNA damage-binding protein 1-like K10610 DDB1; DNA damage-binding protein 1
F 122557892 ddb1; DNA damage-binding protein 1 isoform X1 K10610 DDB1; DNA damage-binding protein 1
F 122549484 ercc8; DNA excision repair protein ERCC-8 isoform X1 K10570 ERCC8; DNA excision repair protein ERCC-8
E Other TCR factor
F 122541821 ercc6; DNA excision repair protein ERCC-6 isoform X1 K10841 ERCC6; DNA excision repair protein ERCC-6
F 122559041 uvssa; UV-stimulated scaffold protein A isoform X1 K23720 UVSSA; UV-stimulated scaffold protein A
F 122540167 elof1; transcription elongation factor 1 homolog K25829 ELOF1; transcription elongation factor 1
D TFIIH complex
E 122551844 ercc3; general transcription and DNA repair factor IIH helicase subunit XPB K10843 ERCC3; DNA excision repair protein ERCC-3 [EC:5.6.2.4]
E 122544744 ercc2; general transcription and DNA repair factor IIH helicase subunit XPD isoform X1 K10844 ERCC2; DNA excision repair protein ERCC-2 [EC:5.6.2.3]
E 122557899 gtf2h1; general transcription factor IIH subunit 1 K03141 TFIIH1; transcription initiation factor TFIIH subunit 1
E 122558931 gtf2h2; general transcription factor IIH subunit 2 isoform X1 K03142 TFIIH2; transcription initiation factor TFIIH subunit 2
E 122551017 gtf2h3; general transcription factor IIH subunit 3 isoform X1 K03143 TFIIH3; transcription initiation factor TFIIH subunit 3
E 122552934 gtf2h5; general transcription factor IIH subunit 5 K10845 TTDA; TFIIH basal transcription factor complex TTD-A subunit
E 122558254 cdk7; cyclin-dependent kinase 7 isoform X1 K02202 CDK7; cyclin-dependent kinase 7 [EC:2.7.11.22 2.7.11.23]
E 122559295 ccnh; cyclin-H isoform X1 K06634 CCNH; cyclin H
E 122553465 mnat1; CDK-activating kinase assembly factor MAT1 K10842 MNAT1; CDK-activating kinase assembly factor MAT1
D RPA (replication factor A)
E 122563922 rpa1; replication protein A 70 kDa DNA-binding subunit K07466 RFA1; replication factor A1
E 122549812 rpa3; replication protein A 14 kDa subunit K10740 RPA3; replication factor A3
D Other NER factors
E 122564431 xpa; DNA repair protein complementing XP-A cells K10847 XPA; DNA-repair protein complementing XP-A cells
E 122560887 ercc4; DNA repair endonuclease XPF isoform X1 K10848 ERCC4; DNA excision repair protein ERCC-4 [EC:3.1.-.-]
E 122561302 mms19; MMS19 nucleotide excision repair protein homolog isoform X1 K15075 MET18; DNA repair/transcription protein MET18/MMS19
E 122555873 cul3b; cullin-3b K03869 CUL3; cullin 3
E 122550706 cullin-5 K10612 CUL5; cullin 5
E 122549401 elongin-C K03872 ELOC; elongin-C
E 122563687 eloa; elongin-A isoform X1 K15076 ELOA; elongin-A
E 122542127 eloal; elongin A, like isoform X1 K15076 ELOA; elongin-A
E 122548797 ubap2a; ubiquitin-associated protein 2a isoform X1 K26545 UBAP2; ubiquitin-associated protein 2
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
E 122553175 msh2; DNA mismatch repair protein Msh2 K08735 MSH2; DNA mismatch repair protein MSH2
E 122559042 msh3; DNA mismatch repair protein Msh3 isoform X1 K08736 MSH3; DNA mismatch repair protein MSH3
E 122552720 msh6; DNA mismatch repair protein Msh6 K08737 MSH6; DNA mismatch repair protein MSH6
D MutL homologs
E 122551243 pms1; PMS1 protein homolog 1 isoform X1 K10864 PMS1; DNA mismatch repair protein PMS1
E 122549293 mlh1; DNA mismatch repair protein Mlh1 K08734 MLH1; DNA mismatch repair protein MLH1
E 122560589 pms2; mismatch repair endonuclease PMS2 isoform X1 K10858 PMS2; DNA mismatch repair protein PMS2
E 122554867 mlh3; DNA mismatch repair protein Mlh3 K08739 MLH3; DNA mismatch repair protein MLH3
D DNA polymerase delta complex
E 122542199 pold1; DNA polymerase delta catalytic subunit K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
E 122543102 pold2; DNA polymerase delta subunit 2 K02328 POLD2; DNA polymerase delta subunit 2
E 122550977 pold3; DNA polymerase delta subunit 3 isoform X1 K03504 POLD3; DNA polymerase delta subunit 3
E 122546911 pold4; DNA polymerase delta subunit 4 K03505 POLD4; DNA polymerase delta subunit 4
D RPA (replication factor A)
E 122563922 rpa1; replication protein A 70 kDa DNA-binding subunit K07466 RFA1; replication factor A1
E 122549812 rpa3; replication protein A 14 kDa subunit K10740 RPA3; replication factor A3
D RFC (replication factor C)
E 122551253 rfc1; replication factor C subunit 1 isoform X1 K10754 RFC1; replication factor C subunit 1
E 122556234 rfc4; replication factor C subunit 4 isoform X1 K10755 RFC2_4; replication factor C subunit 2/4
E 122564159 rfc2; replication factor C subunit 2 isoform X1 K10755 RFC2_4; replication factor C subunit 2/4
E 122562741 rfc5; replication factor C subunit 5 isoform X1 K10756 RFC3_5; replication factor C subunit 3/5
E 122550799 rfc3; replication factor C subunit 3 isoform X1 K10756 RFC3_5; replication factor C subunit 3/5
D Other MMR factors
E 122543049 pcna; proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
E 122552672 exo1; exonuclease 1 K10746 EXO1; exonuclease 1 [EC:3.1.-.-]
E 122540833 WD repeat-containing protein 76-like K24755 WDR76; WD repeat-containing protein 76
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D MRN(MRX) complex
E 122550567 mre11a; double-strand break repair protein MRE11 isoform X1 K10865 MRE11; double-strand break repair protein MRE11
E 122556500 rad50; DNA repair protein RAD50 isoform X1 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
E 122549007 nbn; nibrin isoform X1 K10867 NBN; nibrin
D BRCA1-core complex
E 122551437 bard1; BRCA1-associated RING domain protein 1 isoform X1 K10683 BARD1; BRCA1-associated RING domain protein 1
D BRCA1-A complex
E 122539447 abraxas1; BRCA1-A complex subunit Abraxas 1 isoform X1 K20774 FAM175A; BRCA1-A complex subunit Abraxas
E 122565118 BRISC and BRCA1-A complex member 1-like K20776 BABAM; BRISC and BRCA1-A complex member 1
E 122548495 babam2; BRISC and BRCA1-A complex member 2 isoform X1 K12173 BRE; BRCA1-A complex subunit BRE
E 122557179 brcc3; lys-63-specific deubiquitinase BRCC36 K11864 BRCC3; BRCA1/BRCA2-containing complex subunit 3 [EC:3.4.19.-]
D BRCA1-B complex
E 122563895 brip1; Fanconi anemia group J protein isoform X1 K15362 BRIP1; fanconi anemia group J protein [EC:5.6.2.3]
E 122564493 topbp1; DNA topoisomerase 2-binding protein 1 K10728 TOPBP1; topoisomerase (DNA) II binding protein 1
D BRCA1-C complex
E 122559583 rbbp8; DNA endonuclease RBBP8 K20773 RBBP8; DNA endonuclease RBBP8 [EC:3.1.-.-]
E 122550567 mre11a; double-strand break repair protein MRE11 isoform X1 K10865 MRE11; double-strand break repair protein MRE11
E 122556500 rad50; DNA repair protein RAD50 isoform X1 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
E 122549007 nbn; nibrin isoform X1 K10867 NBN; nibrin
D BRCA complex
E 122551063 brca2; breast cancer type 2 susceptibility protein K08775 BRCA2; breast cancer 2 susceptibility protein
E 122560726 palb2; partner and localizer of BRCA2 isoform X1 K10897 PALB2; partner and localizer of BRCA2
E 122553845 rad51; DNA repair protein RAD51 homolog 1 K04482 RAD51; DNA repair protein RAD51
D RecA family proteins
E 122553845 rad51; DNA repair protein RAD51 homolog 1 K04482 RAD51; DNA repair protein RAD51
E 122553833 rad51b; DNA repair protein RAD51 homolog 2 isoform X1 K10869 RAD51L1; RAD51-like protein 1
E 122563914 rad51c; DNA repair protein RAD51 homolog 3 isoform X1 K10870 RAD51L2; RAD51-like protein 2
E 122564128 rad51d; DNA repair protein RAD51 homolog 4 isoform X1 K10871 RAD51L3; RAD51-like protein 3
E 122550122 xrcc2; DNA repair protein XRCC2 isoform X1 K10879 XRCC2; DNA-repair protein XRCC2
E 122553551 xrcc3; DNA repair protein XRCC3 isoform X1 K10880 XRCC3; DNA-repair protein XRCC3
D Rad52 family proteins
E 122559584 rad52; DNA repair protein RAD52 homolog isoform X1 K10873 RAD52; DNA repair and recombination protein RAD52
E 122539992 rdm1; RAD52 motif-containing protein 1 isoform X1 K10874 RDM1; RAD52 motif-containing protein 1
D Rad54 family proteins
E 122554246 rad54l; DNA repair and recombination protein RAD54-like K10875 RAD54L; DNA repair and recombination protein RAD54 and RAD54-like protein [EC:5.6.2.-]
E 122559151 rad54l2; helicase ARIP4 isoform X1 K10876 RAD54L2; RAD54-like protein 2 [EC:5.6.2.-]
E 122548988 rad54b; DNA repair and recombination protein RAD54B isoform X1 K10877 RAD54B; DNA repair and recombination protein RAD54B [EC:5.6.2.-]
D RecQ family DNA helicases
E 122561590 recql; ATP-dependent DNA helicase Q1 K10899 RECQL; ATP-dependent DNA helicase Q1 [EC:5.6.2.4]
E 122539257 wrn; Werner syndrome ATP-dependent helicase homolog K10900 WRN; werner syndrome ATP-dependent helicase [EC:5.6.2.4]
E 122540880 blm; Bloom syndrome protein homolog isoform X1 K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 122550182 recql4; ATP-dependent DNA helicase Q4 isoform X1 K10730 RECQL4; ATP-dependent DNA helicase Q4 [EC:5.6.2.4]
E 122561953 recql5; ATP-dependent DNA helicase Q5 isoform X1 K10902 RECQL5; ATP-dependent DNA helicase Q5 [EC:5.6.2.4]
D Bloom's syndrome complex (BTR)
E 122540880 blm; Bloom syndrome protein homolog isoform X1 K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 122560696 top3a; DNA topoisomerase 3-alpha isoform X1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 122562832 top3b; DNA topoisomerase 3-beta-1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 122547206 rmi1; recQ-mediated genome instability protein 1 K10990 RMI1; RecQ-mediated genome instability protein 1
E 122560404 rmi2; recQ-mediated genome instability protein 2 K15365 RMI2; RecQ-mediated genome instability protein 2
D RPA (replication factor A)
E 122563922 rpa1; replication protein A 70 kDa DNA-binding subunit K07466 RFA1; replication factor A1
E 122549812 rpa3; replication protein A 14 kDa subunit K10740 RPA3; replication factor A3
D Protein phosphatase 4
E 122562861 serine/threonine-protein phosphatase 4 catalytic subunit K15423 PPP4C; serine/threonine-protein phosphatase 4 catalytic subunit [EC:3.1.3.16]
E 122548870 serine/threonine-protein phosphatase 4 regulatory subunit 1-like isoform X1 K15424 PPP4R1; serine/threonine-protein phosphatase 4 regulatory subunit 1
E 122559972 ppp4r1l; serine/threonine-protein phosphatase 4 regulatory subunit 1 K15424 PPP4R1; serine/threonine-protein phosphatase 4 regulatory subunit 1
E 122559091 ppp4r2b; serine/threonine-protein phosphatase 4 regulatory subunit 2-B isoform X1 K15425 PPP4R2; serine/threonine-protein phosphatase 4 regulatory subunit 2
E 122552882 serine/threonine-protein phosphatase 4 regulatory subunit 3B isoform X1 K17491 SMEK; protein phosphatase 4 regulatory subunit 3
E 122553346 smek1; serine/threonine-protein phosphatase 4 regulatory subunit 3 isoform X1 K17491 SMEK; protein phosphatase 4 regulatory subunit 3
E 122553424 ppp4r4; serine/threonine-protein phosphatase 4 regulatory subunit 4 isoform X1 K15426 PPP4R4; serine/threonine-protein phosphatase 4 regulatory subunit 4
D AP-5 complex
E 122540221 ap5b1; AP-5 complex subunit beta-1 K19022 AP5B1; AP-5 complex subunit beta-1
E 122547302 AP-5 complex subunit mu-1-like isoform X1 K19023 AP5M1; AP-5 complex subunit mu-1
E 122555199 ap5s1; AP-5 complex subunit sigma-1 K19024 AP5S1; AP-5 complex subunit sigma-1
E 122560800 ap5z1; AP-5 complex subunit zeta-1 isoform X1 K19025 AP5Z1; AP-5 complex subunit zeta-1
D SMC5-SMC6 complex
E 122563140 smc5; structural maintenance of chromosomes protein 5 K22803 SMC5; structural maintenance of chromosomes protein 5
E 122540933 structural maintenance of chromosomes protein 6-like K22804 SMC6; structural maintenance of chromosomes protein 6
E 122540973 structural maintenance of chromosomes protein 6-like isoform X1 K22804 SMC6; structural maintenance of chromosomes protein 6
E 122541041 lratd1; protein LRATD1 isoform X1 K22805 FAM84A; protein FAM84A
E 122560709 nsmce1; non-structural maintenance of chromosomes element 1 homolog K22817 NSMCE1; non-structural maintenance of chromosomes element 1 [EC:2.3.2.27]
E 122549180 nsmce2; E3 SUMO-protein ligase NSE2 K22756 NSMCE2; E3 SUMO-protein ligase NSE2 [EC:2.3.2.-]
E 122561170 nsmce4a; non-structural maintenance of chromosomes element 4 homolog A K22825 NSMCE4; non-structural maintenance of chromosomes element 4
E 122561345 slf2; SMC5-SMC6 complex localization factor protein 2 K26127 SLF2; SMC5-SMC6 complex localization factor protein 2
D Other HR factors
E 122562076 eme1; crossover junction endonuclease EME1 K10882 EME1; crossover junction endonuclease EME1 [EC:3.1.22.-]
E 122560452 crossover junction endonuclease EME1-like K10883 EME2; crossover junction endonuclease EME2
E 122553819 exd2; exonuclease 3'-5' domain-containing protein 2 isoform X1 K20777 EXD2; exonuclease 3'-5' domain-containing protein 2 [EC:3.1.11.1]
E 122549823 sem1; 26S proteasome complex subunit SEM1 K10881 SHFM1; 26 proteasome complex subunit DSS1
E 122539787 swi5; DNA repair protein SWI5 homolog isoform X1 K10991 SWI5; DNA repair protein Swi5/Sae3
E 122561261 sfr1; swi5-dependent recombination DNA repair protein 1 homolog K10992 SFR1; Swi5-dependent recombination DNA repair protein 1
E 122560621 slx4; structure-specific endonuclease subunit SLX4 isoform X1 K10484 BTBD12; structure-specific endonuclease subunit SLX4 (BTB/POZ domain-containing protein 12)
E 122540941 flap endonuclease GEN homolog 1-like isoform X1 K15338 GEN1; holliday junction resolvase GEN1/YEN1 [EC:3.1.-.-]
E 122540886 spg11; spatacsin isoform X1 K19026 SPG11; spatacsin
E 122553714 zfyve26; zinc finger FYVE domain-containing protein 26 isoform X1 K19027 ZFYVE26; zinc finger FYVE domain-containing protein 26
E 122540890 morf4l1; mortality factor 4-like protein 1 isoform X1 K11339 MORF4L1; mortality factor 4-like protein 1
E 122560275 samhd1; deoxynucleoside triphosphate triphosphohydrolase SAMHD1 isoform X1 K22544 SAMHD1; deoxynucleoside triphosphate triphosphohydrolase SAMHD1 [EC:3.1.5.-]
E 122560276 deoxynucleoside triphosphate triphosphohydrolase SAMHD1-like isoform X1 K22544 SAMHD1; deoxynucleoside triphosphate triphosphohydrolase SAMHD1 [EC:3.1.5.-]
E 122549903 fignl1; fidgetin-like protein 1 K22766 FIGNL1; fidgetin-like protein 1 [EC:5.6.2.-]
E 122549074 spidr; DNA repair-scaffolding protein isoform X1 K22806 SPIDR; DNA repair-scaffolding protein
E 122549178 protein LRATD2-like K22810 FAM84B; protein FAM84B
E 122560468 brat1; BRCA1-associated ATM activator 1 isoform X1 K23112 BRAT1; BRCA1-associated ATM activator 1
E 122550561 cfap410; cilia and flagella associated protein 410 isoform X1 K23456 CFAP410; cilla- and flagella-associated protein
E 122565215 hdgfl2; hepatoma-derived growth factor-related protein 2 isoform X1 K25065 HDGFL2; hepatoma-derived growth factor-related protein 2
E 122563848 zswim7; zinc finger SWIM domain-containing protein 7 isoform X1 K25770 ZSWIM7; zinc finger SWIM domain-containing protein 7
E 122552221 swsap1; ATPase SWSAP1 isoform X1 K25771 SWSAP1; ATPase SWSAP1
E 122550943 emsy; BRCA2-interacting transcriptional repressor EMSY isoform X1 K25790 EMSY; BRCA2-interacting transcriptional repressor EMSY
E 122554864 heat shock factor 2-binding protein K25791 HSF2BP; heat shock factor 2-binding protein
E 122546782 mms22l; protein MMS22-like isoform X1 K26125 MMS22L; protein MMS22-like
E 122550353 tonsl; tonsoku-like protein K09257 NFKBIL2; NF-kappa-B inhibitor-like protein 2
E 122555030 bod1l1; biorientation of chromosomes in cell division protein 1-like 1 K27262 BOD1L1; biorientation of chromosomes in cell division protein 1-like 1
E 122559343 PCNA-interacting partner isoform X1 K27412 PARPBP; PCNA-interacting partner
C NHEJ (non-homologous end-joining)
D DNA-PK complex
E 122542281 xrcc6; X-ray repair cross-complementing protein 6 isoform X1 K10884 XRCC6; ATP-dependent DNA helicase 2 subunit 1
E 122551960 xrcc5; X-ray repair cross-complementing protein 5 K10885 XRCC5; ATP-dependent DNA helicase 2 subunit 2
E 122549078 prkdc; DNA-dependent protein kinase catalytic subunit isoform X1 K06642 PRKDC; DNA-dependent protein kinase catalytic subunit [EC:2.7.11.1]
D MRX complex
E 122550567 mre11a; double-strand break repair protein MRE11 isoform X1 K10865 MRE11; double-strand break repair protein MRE11
E 122556500 rad50; DNA repair protein RAD50 isoform X1 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
D DNA Ligase 4 complex
E 122550447 lig4; DNA ligase 4 isoform X1 K10777 LIG4; DNA ligase 4 [EC:6.5.1.1]
E 122559138 xrcc4; DNA repair protein XRCC4 isoform X1 K10886 XRCC4; DNA-repair protein XRCC4
E 122551808 nhej1; non-homologous end-joining factor 1 isoform X1 K10980 NHEJ1; non-homologous end-joining factor 1
D X-family DNA polymerases
E 122561277 poll; DNA polymerase lambda isoform X1 K03512 POLL; DNA polymerase lambda [EC:2.7.7.7 4.2.99.-]
E 122561105 dntt; DNA nucleotidylexotransferase isoform X1 K00977 DNTT; DNA nucleotidylexotransferase [EC:2.7.7.31]
E 122543109 polm; DNA-directed DNA/RNA polymerase mu isoform X1 K00977 DNTT; DNA nucleotidylexotransferase [EC:2.7.7.31]
E 122543169 polb; DNA polymerase beta isoform X1 K02330 POLB; DNA polymerase beta [EC:2.7.7.7 4.2.99.-]
D Other NHEJ factors
E 122563017 aptx; aprataxin K10863 APTX; aprataxin [EC:3.6.1.70 3.6.1.71 3.6.1.72]
E 122553108 aplf; aprataxin and PNK-like factor K13295 APLF; aprataxin and PNK-like factor [EC:3.1.-.-]
E 122561483 dclre1c; protein artemis K10887 DCLRE1C; DNA cross-link repair 1C protein [EC:3.1.-.-]
E 122564390 tdp2b; tyrosyl-DNA phosphodiesterase 2 K19619 TDP2; tyrosyl-DNA phosphodiesterase 2 [EC:3.1.4.-]
E 122549043 smchd1; structural maintenance of chromosomes flexible hinge domain-containing protein 1 isoform X1 K23113 SMCHD1; structural maintenance of chromosomes flexible hinge domain-containing protein 1
E 122565401 PWWP domain-containing DNA repair factor 3A-like isoform X1 K23386 PWWP3; PWWP domain-containing DNA repair factor 3
E 122564754 paxx; protein PAXX isoform X1 K25772 PAXX; protein PAXX
E 122560458 jmjd8; LOW QUALITY PROTEIN: jmjC domain-containing protein 8 K25792 JMJD8; jumonji domain-containing protein 8
E 122541766 shld2; shieldin complex subunit 2 K26129 SHLD2; shieldin complex subunit 2
E 122549748 zgc:101664; shieldin complex subunit 3 K26130 SHLD3; shieldin complex subunit 3
C FA (Fanconi anemia) pathway
D FA core complex
E 122558337 Fanconi anemia group A protein-like isoform X1 K10888 FANCA; fanconi anemia group A protein
E 122555001 fancb; Fanconi anemia group B protein K10889 FANCB; fanconi anemia group B protein
E 122563255 fance; Fanconi anemia group E protein isoform X1 K10892 FANCE; fanconi anemia group E protein
E 122557633 fancf; Fanconi anemia group F protein K10893 FANCF; fanconi anemia group F protein
E 122548900 fancg; Fanconi anemia group G protein isoform X1 K10894 FANCG; fanconi anemia group G protein
E 122552888 fancl; E3 ubiquitin-protein ligase FANCL isoform X1 K10606 FANCL; E3 ubiquitin-protein ligase FANCL [EC:2.3.2.27]
E 122553493 fancm; Fanconi anemia group M protein isoform X1 K10896 FANCM; fanconi anemia group M protein
E 122562168 faap100; Fanconi anemia core complex-associated protein 100 isoform X1 K10993 FAAP100; fanconi anemia core complex 100 kDa subunit
D FA core complex binding factors
E 122556308 her6; hairy-related 6 K06054 HES1; hairy and enhancer of split 1
E 122540148 her9; hairy-related 9 isoform X1 K06054 HES1; hairy and enhancer of split 1
E 122540444 cenps; centromere protein S K11511 APITD1; centromere protein S
E 122562245 cenpx; centromere protein X K15360 STRA13; centromere protein X
E 122563225 ube2t; ubiquitin-conjugating enzyme E2 T K13960 UBE2T; ubiquitin-conjugating enzyme E2 T [EC:2.3.2.23]
D Bloom's syndrome complex (BTR)
E 122540880 blm; Bloom syndrome protein homolog isoform X1 K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 122560696 top3a; DNA topoisomerase 3-alpha isoform X1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 122562832 top3b; DNA topoisomerase 3-beta-1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 122547206 rmi1; recQ-mediated genome instability protein 1 K10990 RMI1; RecQ-mediated genome instability protein 1
E 122560404 rmi2; recQ-mediated genome instability protein 2 K15365 RMI2; RecQ-mediated genome instability protein 2
D FANCD2-I complex
E 122558840 fancd2; Fanconi anemia group D2 protein K10891 FANCD2; fanconi anemia group D2 protein
E 122540939 fanci; Fanconi anemia group I protein isoform X1 K10895 FANCI; fanconi anemia group I protein
D Downstream FA components
E 122551063 brca2; breast cancer type 2 susceptibility protein K08775 BRCA2; breast cancer 2 susceptibility protein
E 122563895 brip1; Fanconi anemia group J protein isoform X1 K15362 BRIP1; fanconi anemia group J protein [EC:5.6.2.3]
E 122560726 palb2; partner and localizer of BRCA2 isoform X1 K10897 PALB2; partner and localizer of BRCA2
D Other FA pathway factors
E 122542512 fan1; fanconi-associated nuclease 1 isoform X1 K15363 FAN1; fanconi-associated nuclease 1 [EC:3.1.21.- 3.1.4.1]
E 122553845 rad51; DNA repair protein RAD51 homolog 1 K04482 RAD51; DNA repair protein RAD51
E 122563914 rad51c; DNA repair protein RAD51 homolog 3 isoform X1 K10870 RAD51L2; RAD51-like protein 2
E 122560640 telo2; telomere length regulation protein TEL2 homolog isoform X1 K11137 TELO2; telomere length regulation protein
E 122554440 usp1; ubiquitin carboxyl-terminal hydrolase 1 isoform X1 K11832 USP1; ubiquitin carboxyl-terminal hydrolase 1 [EC:3.4.19.12]
E 122550138 WD repeat-containing protein 48 isoform X1 K15361 WDR48; WD repeat-containing protein 48
C Other DSBR factors
D Protein phosphatase 6
E 122564850 ppp6c; serine/threonine-protein phosphatase 6 catalytic subunit K15498 PPP6C; serine/threonine-protein phosphatase 6 catalytic subunit [EC:3.1.3.16]
E 122542217 serine/threonine-protein phosphatase 6 regulatory subunit 3-like K15499 PPP6R1; serine/threonine-protein phosphatase 6 regulatory subunit 1
E 122558092 ppp6r3; serine/threonine-protein phosphatase 6 regulatory subunit 3 K15501 PPP6R3; serine/threonine-protein phosphatase 6 regulatory subunit 3
E 122550224 serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A-like K15502 ANKRD28; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A
E 122551273 serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B-like isoform X1 K15503 ANKRD44; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B
D Ubiquitin ligases
E 122555722 rnf168; E3 ubiquitin-protein ligase rnf168 K20779 RNF168; E3 ubiquitin-protein ligase RNF168 [EC:2.3.2.31]
E 122550976 rnf169; E3 ubiquitin-protein ligase RNF169 isoform X1 K20805 RNF169; E3 ubiquitin-protein ligase RNF169 [EC:2.3.2.31]
E 122550888 herc2; E3 ubiquitin-protein ligase HERC2 isoform X1 K10595 HERC2; E3 ubiquitin-protein ligase HERC2 [EC:2.3.2.26]
D Others
E 122544306 wrap53; telomerase Cajal body protein 1 K23314 WRAP53; telomerase Cajal body protein 1
E 122564711 tprn; taperin K24164 TPRN; taperin
E 122544360 zinc finger CW-type PWWP domain protein 1-like K24688 ZCWPW1; zinc finger CW-type PWWP domain protein 1
E 122558023 WD repeat-containing protein 70 K24752 WDR70; WD repeat-containing protein 70
E 122540833 WD repeat-containing protein 76-like K24755 WDR76; WD repeat-containing protein 76
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
D 122565268 poli; DNA polymerase iota isoform X1 K03510 POLI; DNA polymerase iota [EC:2.7.7.7]
D 122550635 rev1; DNA repair protein REV1 isoform X1 K03515 REV1; DNA repair protein REV1 [EC:2.7.7.-]
C B-family DNA polymerases
D 122548455 rev3l; DNA polymerase zeta catalytic subunit isoform X1 K02350 REV3L; DNA polymerase zeta [EC:2.7.7.7]
C A-family DNA polymerase
D 122556926 poln; DNA polymerase nu K16618 POLN; DNA polymerase nu [EC:2.7.7.7]
C Rad6 epistasis group
D 122547110 ubiquitin-conjugating enzyme E2 A-like K10573 UBE2A; ubiquitin-conjugating enzyme E2 A [EC:2.3.2.23]
D 122557408 ube2a; ubiquitin-conjugating enzyme E2 A isoform X1 K10573 UBE2A; ubiquitin-conjugating enzyme E2 A [EC:2.3.2.23]
D 122559168 rad18; E3 ubiquitin-protein ligase RAD18 isoform X1 K10627 RAD18; E3 ubiquitin-protein ligase RAD18 [EC:2.3.2.27]
D 122556170 hltf; helicase-like transcription factor isoform X1 K15711 SMARCA3; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A3 [EC:5.6.2. 2.3.2.27]
D 122549082 ube2v2; ubiquitin-conjugating enzyme E2 variant 2 isoform X1 K10704 UBE2V; ubiquitin-conjugating enzyme E2 variant
D 122560067 ubiquitin-conjugating enzyme E2 variant 1-like K10704 UBE2V; ubiquitin-conjugating enzyme E2 variant
D 122561560 ubiquitin-conjugating enzyme E2 N K10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23]
C Other TLS factors
D 122543049 pcna; proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
D 122559343 PCNA-interacting partner isoform X1 K27412 PARPBP; PCNA-interacting partner
D 122542810 sprtn; DNA-dependent metalloprotease SPRTN K24051 SPRTN; SprT-like domain-contaning protein Spartan
D 122557249 gcna; acidic repeat-containing protein K26957 GCNA; germ cell nuclear acidic protein
B Check point factors
C Rad9-Hus1-Rad1 complex
D 122549968 hus1; checkpoint protein HUS1 K10903 HUS1; HUS1 checkpoint protein
D 122558166 rad1; cell cycle checkpoint protein RAD1 K02830 HRAD1; cell cycle checkpoint protein [EC:3.1.11.2]
C HRAD17(Rad24)-RFC complex
D 122558960 rad17; cell cycle checkpoint protein RAD17 K06662 HRAD17; cell cycle checkpoint protein
D 122556234 rfc4; replication factor C subunit 4 isoform X1 K10755 RFC2_4; replication factor C subunit 2/4
D 122564159 rfc2; replication factor C subunit 2 isoform X1 K10755 RFC2_4; replication factor C subunit 2/4
D 122562741 rfc5; replication factor C subunit 5 isoform X1 K10756 RFC3_5; replication factor C subunit 3/5
D 122550799 rfc3; replication factor C subunit 3 isoform X1 K10756 RFC3_5; replication factor C subunit 3/5
C Rad17-Mec3-Ddc1 complex
D 122558166 rad1; cell cycle checkpoint protein RAD1 K02830 HRAD1; cell cycle checkpoint protein [EC:3.1.11.2]
C FPC (fork protection complex)
D 122543206 protein timeless homolog isoform X1 K10997 TIMELESS; replication fork protection complex subunit TIMELESS/Tof1/Swi1
D 122540869 tipin; TIMELESS-interacting protein K10998 TIPIN; replication fork protection complex subunit TIPIN/Csm3/Swi3
D 122563667 claspin isoform X1 K25773 CLSPN; claspin
C Triple T complex
D 122560640 telo2; telomere length regulation protein TEL2 homolog isoform X1 K11137 TELO2; telomere length regulation protein
D 122560027 tti1; TELO2-interacting protein 1 homolog K20403 TTI1; TELO2-interacting protein 1
D 122543096 tti2; TELO2-interacting protein 2 K23115 TTI2; TELO2-interacting protein 2
C BAG6-UBL4A-GET4 complex
D 122541405 large proline-rich protein BAG6-like isoform X1 K23390 BAG6; large proline-rich protein BAG6
D 122545329 ubl4a; ubiquitin-like protein 4A K23388 UBL4; ubiquitin-like protein 4
D 122560573 get4; Golgi to ER traffic protein 4 homolog K23387 GET4; golgi to ER traffic protein 4
C Other check point factors
D 122556218 atr; serine/threonine-protein kinase ATR K06640 ATR; serine/threonine-protein kinase ATR [EC:2.7.11.1]
D 122558923 ATR-interacting protein isoform X1 K10905 ATRIP; ATR interacting protein
D 122550707 atm; serine-protein kinase ATM K04728 ATM; serine-protein kinase ATM [EC:2.7.11.1]
D 122543388 tp53; cellular tumor antigen p53 K04451 TP53; tumor protein p53
D 122540735 chek1; serine/threonine-protein kinase Chk1 K02216 CHEK1; serine/threonine-protein kinase CHEK1 [EC:2.7.11.1]
D 122562547 chek2; serine/threonine-protein kinase Chk2 K06641 CHEK2; serine/threonine-protein kinase CHEK2 [EC:2.7.11.1]
D 122552681 cdc25b; M-phase inducer phosphatase 2 K05866 CDC25B; M-phase inducer phosphatase 2 [EC:3.1.3.48]
D 122556870 M-phase inducer phosphatase 1-B-like K05867 CDC25C; M-phase inducer phosphatase 3 [EC:3.1.3.48]
D 122560317 14-3-3 protein beta/alpha-1-like isoform X1 K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
D 122549153 14-3-3 protein beta/alpha-1 K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
D 122563554 14-3-3 protein beta/alpha-1-like K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
D 122541355 ywhaqa; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide a K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
D 122548305 14-3-3 protein gamma-A-like K16198 YWHAG_H; 14-3-3 protein gamma/eta
D 122564154 14-3-3 protein gamma-1 K16198 YWHAG_H; 14-3-3 protein gamma/eta
D 122563877 ywhae1; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 1 isoform X1 K06630 YWHAE; 14-3-3 protein epsilon
D 122557622 nav2a; neuron navigator 2 isoform X1 K19483 NAV2; neuron navigator 2 [EC:5.6.2.4]
D 122547196 wee1-like protein kinase 1-B isoform X1 K06632 WEE1; wee1-like protein kinase [EC:2.7.11.1]
D 122559463 wee1-like protein kinase 2-A K06632 WEE1; wee1-like protein kinase [EC:2.7.11.1]
D 122555832 per2; period circadian protein homolog 2 isoform X1 K02633 PER2; period circadian protein 2
D 122557098 plastin-3-like K17336 PLS3; plastin-3
D 122540814 apoptosis-enhancing nuclease-like K18340 AEN; apoptosis-enhancing nuclease [EC:3.1.-.-]
D 122554272 serine/threonine-protein kinase PLK2-like K08862 PLK3; polo-like kinase 3 [EC:2.7.11.21]
D 122556606 nek1; serine/threonine-protein kinase Nek1 isoform X1 K08857 NEK1_4_5; serine/threonine-protein kinase Nek1/4/5 [EC:2.7.11.1]
D 122550834 serine/threonine-protein kinase Nek5-like isoform X1 K08857 NEK1_4_5; serine/threonine-protein kinase Nek1/4/5 [EC:2.7.11.1]
D 122549666 nek10; serine/threonine-protein kinase Nek10 K20879 NEK10; serine/threonine-protein kinase Nek10 [EC:2.7.11.1]
D 122564542 nek11; serine/threonine-protein kinase Nek11 isoform X1 K20880 NEK11; serine/threonine-protein kinase Nek11 [EC:2.7.11.1]
D 122543791 protein downstream neighbor of Son-like isoform X1 K22422 DONSON; protein downstream neighbor of Son
D 122555365 protein downstream neighbor of son homolog K22422 DONSON; protein downstream neighbor of Son
D 122552210 KN motif and ankyrin repeat domain-containing protein 2-like K22808 KANK; KN motif and ankyrin repeat domain-containing protein
D 122554489 KN motif and ankyrin repeat domain-containing protein 1-like K22808 KANK; KN motif and ankyrin repeat domain-containing protein
D 122563940 kank1a; KN motif and ankyrin repeat domain-containing protein 1a isoform X1 K22808 KANK; KN motif and ankyrin repeat domain-containing protein
D 122565278 kank3; KN motif and ankyrin repeat domain-containing protein 3 K22808 KANK; KN motif and ankyrin repeat domain-containing protein
D 122549032 charged multivesicular body protein 4b-like K24782 CHMP4C; charged multivesicular body protein 4C
D 122549719 vacuolar protein sorting-associated protein 4B-like isoform X1 K12196 VPS4; vacuolar protein-sorting-associated protein 4
D 122558170 vacuolar protein sorting-associated protein 4A K12196 VPS4; vacuolar protein-sorting-associated protein 4
D 122553843 zfyve19; abscission/NoCut checkpoint regulator isoform X1 K24778 ZFYVE19; abscission/NoCut checkpoint regulator
D 122548520 sde2; replication stress response regulator SDE2 K25059 SDE2; replication stress response regulator SDE2
B Other factors with a suspected DNA repair function
C DNA polymerases
D 122555222 polq; DNA polymerase theta isoform X1 K02349 POLQ; DNA polymerase theta [EC:2.7.7.7]
D 122564233 mybbp1a; myb-binding protein 1A-like protein K02331 POL5; DNA polymerase phi [EC:2.7.7.7]
D 122557753 primpol; DNA-directed primase/polymerase protein isoform X1 K22761 PRIMPOL; DNA-directed primase/polymerase protein [EC:2.7.7.102 2.7.7.7]
C Nucleases
D 122561205 dclre1a; DNA cross-link repair 1A protein K15340 DCLRE1A; DNA cross-link repair 1A protein
D 122563283 dclre1b; 5' exonuclease Apollo isoform X1 K15341 DCLRE1B; DNA cross-link repair 1B protein [EC:3.1.-.-]
D 122563967 exo5; exonuclease V K17815 EXO5; exonuclease V [EC:3.1.-.-]
D 122546884 endonuclease V-like K21813 ENDOV; endonuclease V [EC:3.1.26.-]
D 122551700 zranb3; DNA annealing helicase and endonuclease ZRANB3 isoform X1 K25861 ZRANB3; DNA annealing helicase and endonuclease ZRANB3 [EC:5.6.2.- 3.1.-.-]
D 122565447 ankle1; ankyrin repeat and LEM domain-containing protein 1 isoform X1 K21411 ANKLE1; ankyrin repeat and LEM domain-containing protein 1
C Helicases
D 122539445 helq; helicase POLQ-like isoform X1 K19178 HELQ; POLQ-like helicase [EC:5.6.2.4]
D 122561607 ercc6l2; DNA excision repair protein ERCC-6-like 2 isoform X1 K20098 ERCC6L2; DNA excision repair protein ERCC-6-like 2 [EC:5.6.2.-]
C PSO4 complex
D 122543802 cdc5l; cell division cycle 5-like protein K12860 CDC5L; pre-mRNA-splicing factor CDC5/CEF1
D 122563296 bcas2; pre-mRNA-splicing factor SPF27 K12861 BCAS2; pre-mRNA-splicing factor SPF27
D 122554877 plrg1; pleiotropic regulator 1 isoform X1 K12862 PLRG1; pleiotropic regulator 1
C Modulation of nucleotide pools
D 122554941 nudt15; nucleotide triphosphate diphosphatase NUDT15 isoform X1 K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D 122560760 nudt1; 7,8-dihydro-8-oxoguanine triphosphatase K17816 NUDT1; 8-oxo-dGTP diphosphatase / 2-hydroxy-dATP diphosphatase [EC:3.6.1.55 3.6.1.56]
D 122542976 8-oxo-dGDP phosphatase NUDT18-like K17817 NUDT18; 8-oxo-dGDP phosphatase [EC:3.6.1.58]
D 122544204 deoxyuridine 5'-triphosphate nucleotidohydrolase-like K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 122542460 deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial-like isoform X1 K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 122550984 rrm1; ribonucleoside-diphosphate reductase large subunit K10807 RRM1; ribonucleoside-diphosphate reductase subunit M1 [EC:1.17.4.1]
D 122563659 rrm2; ribonucleoside-diphosphate reductase subunit M2 isoform X1 K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]
D 122541317 ribonucleoside-diphosphate reductase subunit M2 K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]
#
AProkaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D 122556033 CPD photolyase K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]
C BER (base exicision repair)
D DNA glycosylases
E 122562560 unga; uracil DNA glycosylase a K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E 122548640 mpg; DNA-3-methyladenine glycosylase K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]
E 122554299 mutyh; adenine DNA glycosylase isoform X1 K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
E 122560515 nthl1; endonuclease III-like protein 1 isoform X1 K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
D RecJ
D DNA ligase
D DNA polymerase I
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase complex (RNAP)
E TRCF (transcription-repair coupling factor)
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
D Molecular matchmaker
D Strand discrimination factor
D DNA exonucleases
D DNA polymerase III holoenzyme
D DNA ligase
D Other MMR factors
E 122556765 ssbp1; single-stranded DNA-binding protein, mitochondrial K03111 ssb; single-strand DNA-binding protein
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D RecBC pathway proteins
D RecFOR pathway proteins
D AddAB pathway proteins
D Other HR factor
D Archaeal homologous recombinant proteins
C NHEJ (non-homologous end-joining)
D Two-component NHEJ DNA repair complex
D SHIIR (short-homology-independent illegitimate recombination)
E Facilitator
E Supressor
D SHDIR (short-homology-dependent illegitimate recombination)
E RecET pathway
E Facilitator
E Supressor
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
C Other SOS response factors
D 122556765 ssbp1; single-stranded DNA-binding protein, mitochondrial K03111 ssb; single-strand DNA-binding protein
B Other factors with a suspected DNA repair function
C DNA polymerase
C DNA helicases
C Modulation of nucleotide pools
D 122554941 nudt15; nucleotide triphosphate diphosphatase NUDT15 isoform X1 K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D 122544204 deoxyuridine 5'-triphosphate nucleotidohydrolase-like K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 122542460 deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial-like isoform X1 K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
C Others
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#
#[ BRITE | KEGG2 | KEGG ]
#Last updated: March 29, 2024