+E Replication protein KO
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DNA Replication Proteins - Cavia porcellus (domestic guinea pig)
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AEukaryotic type
B DNA Replication Initiation Factors
C pre-RC (pre-replication complex)
D 100724157 Orc1; origin recognition complex subunit 1 K02603 ORC1; origin recognition complex subunit 1
D 100718829 Orc2; origin recognition complex subunit 2 isoform X1 K02604 ORC2; origin recognition complex subunit 2
D 100727573 Orc3; origin recognition complex subunit 3 isoform X2 K02605 ORC3; origin recognition complex subunit 3
D 100731516 Orc4; origin recognition complex subunit 4 K02606 ORC4; origin recognition complex subunit 4
D 100727217 Orc5; LOW QUALITY PROTEIN: origin recognition complex subunit 5 K02607 ORC5; origin recognition complex subunit 5
D 100728517 Orc6; origin recognition complex subunit 6 isoform X4 K02608 ORC6; origin recognition complex subunit 6
D 100733165 Cdt1; DNA replication factor Cdt1 isoform X2 K10727 CDT1; chromatin licensing and DNA replication factor 1
D 100729621 Cdc6; cell division control protein 6 homolog K02213 CDC6; cell division control protein 6
D 100722936 Mcm2; DNA replication licensing factor MCM2 K02540 MCM2; DNA replication licensing factor MCM2 [EC:5.6.2.3]
D 100729563 Mcm3; DNA replication licensing factor MCM3 isoform X2 K02541 MCM3; DNA replication licensing factor MCM3 [EC:5.6.2.3]
D 100724549 Mcm4; DNA replication licensing factor MCM4 isoform X2 K02212 MCM4; DNA replication licensing factor MCM4 [EC:5.6.2.3]
D 100712965 Mcm5; DNA replication licensing factor MCM5 isoform X1 K02209 MCM5; DNA replication licensing factor MCM5 [EC:5.6.2.3]
D 100731891 Mcm6; DNA replication licensing factor MCM6 K02542 MCM6; DNA replication licensing factor MCM6 [EC:5.6.2.3]
D 100719227 Mcm7; DNA replication licensing factor MCM7 isoform X1 K02210 MCM7; DNA replication licensing factor MCM7 [EC:5.6.2.3]
C CDK (cyclin dependent kinase)
D 100716489 Ccna1; cyclin-A1 isoform X1 K06627 CCNA; cyclin-A
D 100716947 Ccna2; cyclin-A2 K06627 CCNA; cyclin-A
D 100727568 Ccne1; G1/S-specific cyclin-E1 K06626 CCNE; G1/S-specific cyclin-E1
D 100734034 Ccne2; G1/S-specific cyclin-E2 K06626 CCNE; G1/S-specific cyclin-E1
D 100714324 Cdk2; cyclin-dependent kinase 2 isoform X2 K02206 CDK2; cyclin-dependent kinase 2 [EC:2.7.11.22]
C DDK (Dbf-4 dependent kinase)
D 100716321 Cdc7; cell division cycle 7-related protein kinase isoform X1 K02214 CDC7; cell division control protein 7 [EC:2.7.11.1]
D 100726964 Dbf4; protein DBF4 homolog A isoform X1 K06629 DBF4; protein DBF4
C GINS complex
D 100729290 Gins1; DNA replication complex GINS protein PSF1 K10732 GINS1; GINS complex subunit 1
D 100725875 Gins2; DNA replication complex GINS protein PSF2 K10733 GINS2; GINS complex subunit 2
D 100719050 Gins3; DNA replication complex GINS protein PSF3 K10734 GINS3; GINS complex subunit 3
D 100723702 Gins4; DNA replication complex GINS protein SLD5 isoform X1 K10735 GINS4; GINS complex subunit 4
C Other initiation factors
D 100721641 Topbp1; DNA topoisomerase 2-binding protein 1 K10728 TOPBP1; topoisomerase (DNA) II binding protein 1
D 100736086 Recql4; ATP-dependent DNA helicase Q4 isoform X2 K10730 RECQL4; ATP-dependent DNA helicase Q4 [EC:5.6.2.4]
D 100728375 Cdc45; cell division control protein 45 homolog K06628 CDC45; cell division control protein 45
D 100734936 Mcm8; DNA helicase MCM8 K10737 MCM8; DNA helicase MCM8 [EC:5.6.2.4]
D 100733089 Mcm9; DNA helicase MCM9 K10738 MCM9; DNA helicase MCM9 [EC:5.6.2.4]
D 100724190 Mcm10; protein MCM10 homolog K10736 MCM10; minichromosome maintenance protein 10
D 100715558 Mcmbp; mini-chromosome maintenance complex-binding protein isoform X1 K28390 MCMBP; minichromosome maintenance complex-binding protein
D 106029013 Helb; DNA helicase B isoform X1 K15254 HELB; DNA helicase B [EC:5.6.2.3]
D 100722692 protein FAM111A K24274 FAM111A; protein FAM111A
D 106026349 protein FAM111A-like K24274 FAM111A; protein FAM111A
D 100720578 Cinp; cyclin-dependent kinase 2-interacting protein K26052 CINP; cyclin-dependent kinase 2-interacting protein
D 100723512 Mtbp; mdm2-binding protein isoform X1 K26116 MTBP; Mdm2-binding protein
D 100728636 Ticrr; treslin K26117 TICRR; Treslin
B DNA Replication Elongation Factors
C DNA polymerase alpha / primase complex
D 100717633 Pola1; DNA polymerase alpha catalytic subunit isoform X1 K02320 POLA1; DNA polymerase alpha subunit A [EC:2.7.7.7]
D 100727306 Pola2; DNA polymerase alpha subunit B isoform X1 K02321 POLA2; DNA polymerase alpha subunit B
D 100730388 Prim1; DNA primase small subunit K02684 PRI1; DNA primase small subunit [EC:2.7.7.102]
D 100726716 Prim2; DNA primase large subunit K02685 PRI2; DNA primase large subunit
C DNA polymerase epsilon complex
D 100729017 Pole; DNA polymerase epsilon catalytic subunit A K02324 POLE; DNA polymerase epsilon subunit 1 [EC:2.7.7.7]
D 100725125 Pole2; DNA polymerase epsilon subunit 2 K02325 POLE2; DNA polymerase epsilon subunit 2 [EC:2.7.7.7]
D 100733855 Pole3; DNA polymerase epsilon subunit 3 K02326 POLE3; DNA polymerase epsilon subunit 3 [EC:2.7.7.7]
D 100735273 Pole4; DNA polymerase epsilon subunit 4 K03506 POLE4; DNA polymerase epsilon subunit 4 [EC:2.7.7.7]
C DNA polymerase delta complex
D 100719673 Pold1; DNA polymerase delta catalytic subunit isoform X1 K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
D 100727561 Pold2; DNA polymerase delta subunit 2 isoform X1 K02328 POLD2; DNA polymerase delta subunit 2
D 100734598 Pold3; DNA polymerase delta subunit 3 isoform X1 K03504 POLD3; DNA polymerase delta subunit 3
D 100732830 Pold4; DNA polymerase delta subunit 4 isoform X1 K03505 POLD4; DNA polymerase delta subunit 4
C DNA polymerase gamma complex (mitochondrial)
D 100728907 Polg; DNA polymerase subunit gamma-1 K02332 POLG; DNA polymerase gamma 1 [EC:2.7.7.7]
D 100718296 Polg2; DNA polymerase subunit gamma-2, mitochondrial K02333 POLG2; DNA polymerase gamma 2
C RPA (replication protein A)
D 100716820 Rpa1; replication protein A 70 kDa DNA-binding subunit K07466 RFA1; replication factor A1
D 100721250 Rpa2; replication protein A 32 kDa subunit K10739 RFA2; replication factor A2
D 100715065 Rpa3; replication protein A 14 kDa subunit K10740 RPA3; replication factor A3
C RFC (replication factor C)
D 100733981 Rfc1; replication factor C subunit 1 isoform X1 K10754 RFC1; replication factor C subunit 1
D 100713099 Rfc2; replication factor C subunit 2 K10755 RFC2_4; replication factor C subunit 2/4
D 100729757 Rfc4; replication factor C subunit 4 isoform X1 K10755 RFC2_4; replication factor C subunit 2/4
D 100714795 Rfc3; replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
D 100723132 Rfc5; replication factor C subunit 5 isoform X1 K10756 RFC3_5; replication factor C subunit 3/5
C RNase H
D 100725358 Rnaseh1; ribonuclease H1 K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
D 100715505 Rnaseh2a; ribonuclease H2 subunit A K10743 RNASEH2A; ribonuclease H2 subunit A [EC:3.1.26.4]
D 100720468 Rnaseh2b; ribonuclease H2 subunit B isoform X2 K10744 RNASEH2B; ribonuclease H2 subunit B
D 100732011 Rnaseh2c; ribonuclease H2 subunit C K10745 RNASEH2C; ribonuclease H2 subunit C
C Other elongation factors
D 100713865 Pcna; proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
D 100718416 Dna2; DNA replication ATP-dependent helicase/nuclease DNA2 isoform X1 K10742 DNA2; DNA replication ATP-dependent helicase/nuclease Dna2 [EC:5.6.2.3 3.1.-.-]
D 100723622 Fen1; flap endonuclease 1 K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
D 100714964 Exo1; exonuclease 1 K10746 EXO1; exonuclease 1 [EC:3.1.-.-]
D 100732438 Zranb3; DNA annealing helicase and endonuclease ZRANB3 isoform X1 K25861 ZRANB3; DNA annealing helicase and endonuclease ZRANB3 [EC:5.6.2.- 3.1.-.-]
D 100734013 Lig1; DNA ligase 1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
D 100720342 Atad5; ATPase family AAA domain-containing protein 5 K26118 ATAD5; ATPase family AAA domain-containing protein 5
B DNA Replication Termination Factors
C DNA methylation enzymes
D 100717406 Dnmt1; LOW QUALITY PROTEIN: DNA (cytosine-5)-methyltransferase 1 K00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]
D 100721625 Dnmt3a; LOW QUALITY PROTEIN: DNA (cytosine-5)-methyltransferase 3A K17398 DNMT3A; DNA (cytosine-5)-methyltransferase 3A [EC:2.1.1.37]
D 100731772 Dnmt3b; DNA (cytosine-5)-methyltransferase 3B K17399 DNMT3B; DNA (cytosine-5)-methyltransferase 3B [EC:2.1.1.37]
C Prevention of re-replication factors
D 100735738 Gmnn; geminin isoform X2 K10749 GMNN; geminin
D 100735650 Mcidas; multicilin K26119 MCIDAS; multicilin
D 100720222 G2/mitotic-specific cyclin-B1 K05868 CCNB1; G2/mitotic-specific cyclin-B1
D 100730790 Ccnb1; G2/mitotic-specific cyclin-B1 K05868 CCNB1; G2/mitotic-specific cyclin-B1
D 100716328 Ccnb2; G2/mitotic-specific cyclin-B2 K21770 CCNB2; G2/mitotic-specific cyclin-B2
D 100713705 Ccnb3; G2/mitotic-specific cyclin-B3 K21771 CCNB3; G2/mitotic-specific cyclin-B3
D 100735946 Cdk1; cyclin-dependent kinase 1 K02087 CDK1; cyclin-dependent kinase 1 [EC:2.7.11.22 2.7.11.23]
C Telomere proteins
D Shelterin complex
E 100725051 Pot1; protection of telomeres protein 1 K11109 POT1; protection of telomeres protein 1
E 100731905 Terf1; telomeric repeat-binding factor 1 K11110 TERF1; telomeric repeat-binding factor 1
E 100723550 Terf2; telomeric repeat-binding factor 2 K11111 TERF2; telomeric repeat-binding factor 2
E 100712757 TERF1-interacting nuclear factor 2-like isoform X1 K11112 TINF2; TERF1-interacting nuclear factor 2
E 100735848 TERF1-interacting nuclear factor 2 isoform X2 K11112 TINF2; TERF1-interacting nuclear factor 2
E 100713942 Terf2ip; LOW QUALITY PROTEIN: telomeric repeat-binding factor 2-interacting protein 1 K11113 TERF2IP; telomeric repeat-binding factor 2-interacting protein 1
E 100730199 Acd; adrenocortical dysplasia protein homolog isoform X5 K11114 ACD; adrenocortical dysplasia protein
D TERB1-TERB2-MAJIN complex
E 100726022 Terb1; telomere repeats-binding bouquet formation protein 1 K25749 TERB1; telomere repeats-binding bouquet formation protein 1
E 100733234 Terb2; telomere repeats-binding bouquet formation protein 2 K25750 TERB2; telomere repeats-binding bouquet formation protein 2
E 100721599 Majin; membrane-anchored junction protein K25751 MAJIN; membrane-anchored junction protein
D CST complex (animals)
E 100729792 Ctc1; CST complex subunit CTC1 isoform X1 K23311 CTC1; CST complex subunit CTC1
E 100723666 Stn1; CST complex subunit STN1 isoform X1 K23312 STN1; CST complex subunit STN1
E 100721015 Ten1; CST complex subunit TEN1 K23313 TEN1; CST complex subunit TEN1
D CST complex (yeast)
D RIF proteins
D SIR proteins
C Telomerase complex (animals)
D 100715692 Smg6; telomerase-binding protein EST1A isoform X1 K11124 SMG6; protein SMG6 [EC:3.1.-.-]
D 100722374 Smg5; protein SMG5 isoform X1 K11125 SMG5; protein SMG5
D 100732437 Tert; LOW QUALITY PROTEIN: telomerase reverse transcriptase K11126 TERT; telomerase reverse transcriptase [EC:2.7.7.49]
D 100721808 telomerase protein component 1-like K11127 TEP1; telomerase protein component 1
D 100722557 Tep1; telomerase protein component 1 K11127 TEP1; telomerase protein component 1
D 100723662 LOW QUALITY PROTEIN: telomerase protein component 1-like K11127 TEP1; telomerase protein component 1
D Dyskerin complex
E 100714195 Gar1; H/ACA ribonucleoprotein complex subunit 1 K11128 GAR1; H/ACA ribonucleoprotein complex subunit 1
E 100729214 Nhp2; H/ACA ribonucleoprotein complex subunit 2 K11129 NHP2; H/ACA ribonucleoprotein complex subunit 2
E 100728268 Nop10; H/ACA ribonucleoprotein complex subunit 3 K11130 NOP10; H/ACA ribonucleoprotein complex subunit 3
E 100721753 Dkc1; H/ACA ribonucleoprotein complex subunit 4 K11131 DKC1; H/ACA ribonucleoprotein complex subunit 4 [EC:5.4.99.-]
C Telomerase complex (fungi)
D 100732437 Tert; LOW QUALITY PROTEIN: telomerase reverse transcriptase K11126 TERT; telomerase reverse transcriptase [EC:2.7.7.49]
D Sm core complex
E 100722475 Snrpb; small nuclear ribonucleoprotein-associated proteins B and B' isoform X2 K11086 SNRPB; small nuclear ribonucleoprotein B and B'
E 100718697 Snrpd1; small nuclear ribonucleoprotein Sm D1 K11087 SNRPD1; small nuclear ribonucleoprotein D1
E 100735810 Snrpd2; small nuclear ribonucleoprotein Sm D2 K11096 SNRPD2; small nuclear ribonucleoprotein D2
E 100720383 Snrpd3; small nuclear ribonucleoprotein Sm D3 K11088 SNRPD3; small nuclear ribonucleoprotein D3
E 100718862 small nuclear ribonucleoprotein E-like K11097 SNRPE; small nuclear ribonucleoprotein E
E 100724868 Snrpe; small nuclear ribonucleoprotein E K11097 SNRPE; small nuclear ribonucleoprotein E
E 100723019 Snrpf; small nuclear ribonucleoprotein F K11098 SNRPF; small nuclear ribonucleoprotein F
E 100725113 Snrpg; small nuclear ribonucleoprotein G isoform X1 K11099 SNRPG; small nuclear ribonucleoprotein G
C ELG1-RFC complex
D 100713099 Rfc2; replication factor C subunit 2 K10755 RFC2_4; replication factor C subunit 2/4
D 100729757 Rfc4; replication factor C subunit 4 isoform X1 K10755 RFC2_4; replication factor C subunit 2/4
D 100714795 Rfc3; replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
D 100723132 Rfc5; replication factor C subunit 5 isoform X1 K10756 RFC3_5; replication factor C subunit 3/5
C MRN complex
D 100721147 Mre11; double-strand break repair protein MRE11 K10865 MRE11; double-strand break repair protein MRE11
D 100719847 Rad50; DNA repair protein RAD50 isoform X2 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
D 100715565 Nbn; nibrin isoform X1 K10867 NBN; nibrin
C Other termination factors
D 100717983 Atm; serine-protein kinase ATM K04728 ATM; serine-protein kinase ATM [EC:2.7.11.1]
D 100719896 Wrn; Werner syndrome ATP-dependent helicase isoform X1 K10900 WRN; werner syndrome ATP-dependent helicase [EC:5.6.2.4]
D 100732874 Blm; Bloom syndrome protein isoform X1 K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
D 100724826 Prkdc; DNA-dependent protein kinase catalytic subunit K06642 PRKDC; DNA-dependent protein kinase catalytic subunit [EC:2.7.11.1]
D 100731330 Ercc4; DNA repair endonuclease XPF K10848 ERCC4; DNA excision repair protein ERCC-4 [EC:3.1.-.-]
D 100733925 Parp1; poly [ADP-ribose] polymerase 1 K24070 PARP1; poly [ADP-ribose] polymerase 1 [EC:2.4.2.30]
D 100720452 Parp2; poly [ADP-ribose] polymerase 2 isoform X1 K28005 PARP2; poly [ADP-ribose] polymerase 2 [EC:2.4.2.30]
D 100719373 Tnks2; LOW QUALITY PROTEIN: tankyrase-2 K10799 TNKS; tankyrase [EC:2.4.2.30]
D 100728577 Tnks; tankyrase-1 K10799 TNKS; tankyrase [EC:2.4.2.30]
D 100717616 Pinx1; PIN2/TERF1-interacting telomerase inhibitor 1 K11135 PINX1; Pin2-interacting protein X1
D 100716322 Rtel1; regulator of telomere elongation helicase 1 isoform X9 K11136 RTEL1; regulator of telomere elongation helicase 1 [EC:5.6.2.3]
D 100728749 Telo2; telomere length regulation protein TEL2 homolog isoform X1 K11137 TELO2; telomere length regulation protein
D 100716629 Trir; telomerase RNA component interacting RNase isoform X1 K01149 TRIR; telomerase RNA component interacting RNase [EC:3.1.13.-]
D 101787829 Rif1; LOW QUALITY PROTEIN: telomere-associated protein RIF1 K11138 RIF1; telomere-associated protein RIF1
D 100723982 Pif1; LOW QUALITY PROTEIN: ATP-dependent DNA helicase PIF1 K15255 PIF1; ATP-dependent DNA helicase PIF1 [EC:5.6.2.3]
D 100726424 Pura; LOW QUALITY PROTEIN: transcriptional activator protein Pur-alpha K21772 PURA; transcriptional activator protein Pur-alpha
D 100720995 Purg; purine-rich element-binding protein gamma K21800 PURG; purine-rich element-binding protein gamma
D 100733673 Wrap53; telomerase Cajal body protein 1 isoform X2 K23314 WRAP53; telomerase Cajal body protein 1
D 100722675 replication stress response regulator SDE2-like K25059 SDE2; replication stress response regulator SDE2
D 100735791 Sde2; replication stress response regulator SDE2 K25059 SDE2; replication stress response regulator SDE2
D 100725813 Rtf2; protein RTF2 homolog isoform X3 K25186 RTF2; replication termination factor 2
B DNA Topoisomerases
C 100716716 Top1; DNA topoisomerase 1 K03163 TOP1; DNA topoisomerase I [EC:5.6.2.1]
C 100728586 Top1mt; DNA topoisomerase I, mitochondrial isoform X2 K03163 TOP1; DNA topoisomerase I [EC:5.6.2.1]
C 100714821 Top2b; DNA topoisomerase 2-beta K03164 TOP2; DNA topoisomerase II [EC:5.6.2.2]
C 100730168 Top2a; DNA topoisomerase 2-alpha isoform X1 K03164 TOP2; DNA topoisomerase II [EC:5.6.2.2]
C 100733021 Top3a; DNA topoisomerase 3-alpha isoform X1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
C 100734860 Top3b; DNA topoisomerase 3-beta-1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
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AProkaryotic type
B DNA Replication Initiation Factors
C Initiation factors (bacterial)
D 100716942 Ssbp1; single-stranded DNA-binding protein, mitochondrial K03111 ssb; single-strand DNA-binding protein
C Initiation factors (archaeal)
B DNA Replication Elongation Factors
C Elongation factors (bacterial)
D DNA polymerase III holoenzyme
D RNase H
E 100725358 Rnaseh1; ribonuclease H1 K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
D Other elongation factors
C Elongation factors (archaeal)
D B-family DNA polymerases
D D-family DNA polymerases
D RNase H
E 100725358 Rnaseh1; ribonuclease H1 K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
D RFC (replication factor C)
D Other elongation factors
E 100718416 Dna2; DNA replication ATP-dependent helicase/nuclease DNA2 isoform X1 K10742 DNA2; DNA replication ATP-dependent helicase/nuclease Dna2 [EC:5.6.2.3 3.1.-.-]
E 100723622 Fen1; flap endonuclease 1 K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
E 100734013 Lig1; DNA ligase 1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
B DNA Replication Termination Factors
C Terminus site-binding protein
C DNA methylation enzymes
C Prevention of re-replication factors
B DNA Topoisomerases
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: August 27, 2025