+F Repair protein KO
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DNA Repair and Recombination Proteins - Cavia porcellus (domestic guinea pig)
%
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AEukaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D 100733185 Mgmt; methylated-DNA--protein-cysteine methyltransferase K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
D 100731606 Alkbh2; DNA oxidative demethylase ALKBH2 K10859 ALKBH2; DNA oxidative demethylase [EC:1.14.11.33]
D 100721589 Alkbh3; alpha-ketoglutarate-dependent dioxygenase alkB homolog 3 isoform X1 K10860 ALKBH3; mRNA N1-methyladenine demethylase [EC:1.14.11.54]
D 100732817 Ascc3; LOW QUALITY PROTEIN: activating signal cointegrator 1 complex subunit 3 K18663 ASCC3; activating signal cointegrator complex subunit 3 [EC:5.6.2.4]
C BER (base exicision repair)
D DNA glycosylases
E 100730581 Ung; uracil-DNA glycosylase K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E 100725926 Ccno; LOW QUALITY PROTEIN: cyclin-O K10861 UDG2; uracil-DNA glycosylase 2 [EC:3.2.2.-]
E 100724604 Tdg; G/T mismatch-specific thymine DNA glycosylase isoform X1 K20813 TDG; thymine-DNA glycosylase [EC:3.2.2.29]
E 100724319 Smug1; single-strand selective monofunctional uracil DNA glycosylase isoform X1 K10800 SMUG1; single-strand selective monofunctional uracil DNA glycosylase [EC:3.2.2.-]
E 100723877 Mutyh; adenine DNA glycosylase isoform X1 K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
E 100715374 Mbd4; methyl-CpG-binding domain protein 4 K10801 MBD4; methyl-CpG-binding domain protein 4 [EC:3.2.2.-]
E 100731436 Ogg1; N-glycosylase/DNA lyase isoform X1 K03660 OGG1; N-glycosylase/DNA lyase [EC:3.2.2.- 4.2.99.18]
E 100735711 Neil1; endonuclease 8-like 1 isoform X2 K10567 NEIL1; endonuclease VIII-like 1 [EC:3.2.2.- 4.2.99.18]
E 100715945 Neil2; endonuclease 8-like 2 K10568 NEIL2; endonuclease VIII-like 2 [EC:3.2.2.- 4.2.99.18]
E 100723918 Neil3; endonuclease 8-like 3 K10569 NEIL3; endonuclease VIII-like 3 [EC:3.2.2.- 4.2.99.18]
E 100732333 Nthl1; endonuclease III-like protein 1 isoform X2 K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
E 100719062 Apex1; DNA-(apurinic or apyrimidinic site) lyase K10771 APEX1; AP endonuclease 1 [EC:3.1.11.2]
E 100722391 Apex2; DNA-(apurinic or apyrimidinic site) lyase 2 K10772 APEX2; AP endonuclease 2 [EC:3.1.11.2]
D Long Patch-BER factors
E DNA polymerase delta complex
F 100719673 Pold1; DNA polymerase delta catalytic subunit isoform X1 K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
F 100727561 Pold2; DNA polymerase delta subunit 2 isoform X1 K02328 POLD2; DNA polymerase delta subunit 2
F 100734598 Pold3; DNA polymerase delta subunit 3 isoform X1 K03504 POLD3; DNA polymerase delta subunit 3
F 100732830 Pold4; DNA polymerase delta subunit 4 isoform X1 K03505 POLD4; DNA polymerase delta subunit 4
E DNA polymerase epsilon complex
F 100729017 Pole; DNA polymerase epsilon catalytic subunit A K02324 POLE; DNA polymerase epsilon subunit 1 [EC:2.7.7.7]
F 100725125 Pole2; DNA polymerase epsilon subunit 2 K02325 POLE2; DNA polymerase epsilon subunit 2 [EC:2.7.7.7]
F 100733855 Pole3; DNA polymerase epsilon subunit 3 K02326 POLE3; DNA polymerase epsilon subunit 3 [EC:2.7.7.7]
F 100735273 Pole4; DNA polymerase epsilon subunit 4 K03506 POLE4; DNA polymerase epsilon subunit 4 [EC:2.7.7.7]
E 100713865 Pcna; proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
E 100723622 Fen1; flap endonuclease 1 K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
E 100734013 Lig1; DNA ligase 1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
D Short Patch-BER factors
E 100731356 Polb; LOW QUALITY PROTEIN: DNA polymerase beta K02330 POLB; DNA polymerase beta [EC:2.7.7.7 4.2.99.-]
E 100727471 Xrcc1; DNA repair protein XRCC1 isoform X1 K10803 XRCC1; DNA-repair protein XRCC1
E 100716163 Lig3; DNA ligase 3 isoform X3 K10776 LIG3; DNA ligase 3 [EC:6.5.1.1]
D Other BER factors
E 100724667 Tdp1; tyrosyl-DNA phosphodiesterase 1 K10862 TDP1; tyrosyl-DNA phosphodiesterase 1 [EC:3.1.4.-]
E 100722168 Aptx; aprataxin isoform X5 K10863 APTX; aprataxin [EC:3.6.1.70 3.6.1.71 3.6.1.72]
E 100729628 Aplf; aprataxin and PNK-like factor K13295 APLF; aprataxin and PNK-like factor [EC:3.1.-.-]
E 100722607 Pnkp; bifunctional polynucleotide phosphatase/kinase isoform X1 K08073 PNKP; bifunctional polynucleotide phosphatase/kinase [EC:3.1.3.32 2.7.1.78]
E 100720324 LOW QUALITY PROTEIN: putative high mobility group protein B1-like 1 K10802 HMGB1; high mobility group protein B1
E 106025160 Hmgb1; high mobility group protein B1 K10802 HMGB1; high mobility group protein B1
E 100729389 Poll; DNA polymerase lambda isoform X2 K03512 POLL; DNA polymerase lambda [EC:2.7.7.7 4.2.99.-]
E 100733925 Parp1; poly [ADP-ribose] polymerase 1 K24070 PARP1; poly [ADP-ribose] polymerase 1 [EC:2.4.2.30]
E 100721827 Parp3; poly [ADP-ribose] polymerase 3 isoform X1 K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
E 100726261 Parp4; poly [ADP-ribose] polymerase 4 K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
E 100720452 Parp2; poly [ADP-ribose] polymerase 2 isoform X1 K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E XPC-HR23B-CETN2 complex
F 100719007 Xpc; DNA repair protein complementing XP-C cells isoform X1 K10838 XPC; xeroderma pigmentosum group C-complementing protein
F 100724104 Rad23b; UV excision repair protein RAD23 homolog B K10839 RAD23; UV excision repair protein RAD23
F 100713642 Rad23a; UV excision repair protein RAD23 homolog A isoform X1 K10839 RAD23; UV excision repair protein RAD23
F 100728564 Cetn2; centrin-2 isoform X3 K10840 CETN2; centrin-2
E Cul4-DDB2 complex
F 100714763 Rbx1; E3 ubiquitin-protein ligase RBX1 K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
F 100736154 Cul4a; cullin-4A K10609 CUL4; cullin 4
F 100714185 Cul4b; cullin-4B isoform X1 K10609 CUL4; cullin 4
F 100724177 Ddb1; DNA damage-binding protein 1 K10610 DDB1; DNA damage-binding protein 1
F 100726538 Ddb2; DNA damage-binding protein 2 isoform X1 K10140 DDB2; DNA damage-binding protein 2
E NER4 complex
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase II complex
F 100734232 Polr2a; LOW QUALITY PROTEIN: DNA-directed RNA polymerase II subunit RPB1 K03006 RPB1; DNA-directed RNA polymerase II subunit RPB1 [EC:2.7.7.6]
F 100731023 Polr2b; DNA-directed RNA polymerase II subunit RPB2 K03010 RPB2; DNA-directed RNA polymerase II subunit RPB2 [EC:2.7.7.6]
F 100723100 Polr2c; DNA-directed RNA polymerase II subunit RPB3 K03011 RPB3; DNA-directed RNA polymerase II subunit RPB3
F 100719830 Polr2d; DNA-directed RNA polymerase II subunit RPB4 K03012 RPB4; DNA-directed RNA polymerase II subunit RPB4
F 100729846 Polr2e; DNA-directed RNA polymerases I, II, and III subunit RPABC1 K03013 RPABC1; DNA-directed RNA polymerases I, II, and III subunit RPABC1
F 100725657 Polr2f; DNA-directed RNA polymerases I, II, and III subunit RPABC2 K03014 RPABC2; DNA-directed RNA polymerases I, II, and III subunit RPABC2
F 100733401 Polr2g; DNA-directed RNA polymerase II subunit RPB7 isoform X1 K03015 RPB7; DNA-directed RNA polymerase II subunit RPB7
F 100726327 Polr2h; DNA-directed RNA polymerases I, II, and III subunit RPABC3 K03016 RPABC3; DNA-directed RNA polymerases I, II, and III subunit RPABC3
F 100727762 Polr2i; DNA-directed RNA polymerase II subunit RPB9 K03017 RPB9; DNA-directed RNA polymerase II subunit RPB9
F 100716116 Polr2l; DNA-directed RNA polymerases I, II, and III subunit RPABC5 K03007 RPABC5; DNA-directed RNA polymerases I, II, and III subunit RPABC5
F 100734905 Polr2j; DNA-directed RNA polymerase II subunit RPB11-a K03008 RPB11; DNA-directed RNA polymerase II subunit RPB11
F 100731078 Polr2k; DNA-directed RNA polymerases I, II, and III subunit RPABC4 K03009 RPABC4; DNA-directed RNA polymerases I, II, and III subunit RPABC4
E Cul4-CSA complex
F 100714763 Rbx1; E3 ubiquitin-protein ligase RBX1 K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
F 100736154 Cul4a; cullin-4A K10609 CUL4; cullin 4
F 100714185 Cul4b; cullin-4B isoform X1 K10609 CUL4; cullin 4
F 100724177 Ddb1; DNA damage-binding protein 1 K10610 DDB1; DNA damage-binding protein 1
F 100720574 Ercc8; DNA excision repair protein ERCC-8 isoform X1 K10570 ERCC8; DNA excision repair protein ERCC-8
E Other TCR factor
F 100719487 Ercc6; DNA excision repair protein ERCC-6 isoform X1 K10841 ERCC6; DNA excision repair protein ERCC-6
F 100729331 Uvssa; UV-stimulated scaffold protein A isoform X3 K23720 UVSSA; UV-stimulated scaffold protein A
F 100722299 Elof1; transcription elongation factor 1 homolog K25829 ELOF1; transcription elongation factor 1
D TFIIH complex
E 100717787 Ercc3; TFIIH basal transcription factor complex helicase XPB subunit K10843 ERCC3; DNA excision repair protein ERCC-3 [EC:5.6.2.4]
E 100721308 Ercc2; TFIIH basal transcription factor complex helicase XPD subunit K10844 ERCC2; DNA excision repair protein ERCC-2 [EC:5.6.2.3]
E 100714157 Gtf2h1; general transcription factor IIH subunit 1 K03141 TFIIH1; transcription initiation factor TFIIH subunit 1
E 100732574 general transcription factor IIH subunit 2 isoform X1 K03142 TFIIH2; transcription initiation factor TFIIH subunit 2
E 100720431 general transcription factor IIH subunit 2-like isoform X1 K03142 TFIIH2; transcription initiation factor TFIIH subunit 2
E 100729404 LOW QUALITY PROTEIN: general transcription factor IIH subunit 2-like K03142 TFIIH2; transcription initiation factor TFIIH subunit 2
E 100733552 Gtf2h2; general transcription factor IIH subunit 2 K03142 TFIIH2; transcription initiation factor TFIIH subunit 2
E 100720023 Gtf2h3; general transcription factor IIH subunit 3 K03143 TFIIH3; transcription initiation factor TFIIH subunit 3
E 101787652 Gtf2h4; general transcription factor IIH subunit 4 K03144 TFIIH4; transcription initiation factor TFIIH subunit 4
E 100717456 Gtf2h5; general transcription factor IIH subunit 5 K10845 TTDA; TFIIH basal transcription factor complex TTD-A subunit
E 100725955 Cdk7; LOW QUALITY PROTEIN: cyclin-dependent kinase 7 K02202 CDK7; cyclin-dependent kinase 7 [EC:2.7.11.22 2.7.11.23]
E 100726162 Ccnh; cyclin-H K06634 CCNH; cyclin H
E 100719238 Mnat1; CDK-activating kinase assembly factor MAT1 K10842 MNAT1; CDK-activating kinase assembly factor MAT1
D RPA (replication factor A)
E 100716820 Rpa1; replication protein A 70 kDa DNA-binding subunit K07466 RFA1; replication factor A1
E 100721250 Rpa2; replication protein A 32 kDa subunit K10739 RFA2; replication factor A2
E 100715065 Rpa3; replication protein A 14 kDa subunit K10740 RPA3; replication factor A3
D Other NER factors
E 100735836 Xpa; DNA repair protein complementing XP-A cells K10847 XPA; DNA-repair protein complementing XP-A cells
E 100734416 Ercc1; DNA excision repair protein ERCC-1 isoform X1 K10849 ERCC1; DNA excision repair protein ERCC-1
E 100731330 Ercc4; DNA repair endonuclease XPF K10848 ERCC4; DNA excision repair protein ERCC-4 [EC:3.1.-.-]
E 100734193 LOW QUALITY PROTEIN: DNA repair protein complementing XP-G cells K10846 ERCC5; DNA excision repair protein ERCC-5
E 100734013 Lig1; DNA ligase 1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
E 100720211 Mms19; MMS19 nucleotide excision repair protein homolog isoform X1 K15075 MET18; DNA repair/transcription protein MET18/MMS19
E 100729326 Cul3; cullin-3 K03869 CUL3; cullin 3
E 100717146 Cul5; cullin-5 K10612 CUL5; cullin 5
E 100729701 Eloc; elongin-C K03872 ELOC; elongin-C
E 100713146 Elob; elongin-B K03873 ELOB; elongin-B
E 100724128 LOW QUALITY PROTEIN: uncharacterized protein LOC100724128 K03873 ELOB; elongin-B
E 100722356 Eloa; elongin-A K15076 ELOA; elongin-A
E 100730762 Ubap2l; ubiquitin-associated protein 2-like isoform X1 K26545 UBAP2; ubiquitin-associated protein 2
E 100724381 Ubap2; ubiquitin-associated protein 2 isoform X1 K26545 UBAP2; ubiquitin-associated protein 2
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
E 100724489 Msh2; DNA mismatch repair protein Msh2 K08735 MSH2; DNA mismatch repair protein MSH2
E 100730041 Msh3; DNA mismatch repair protein Msh3 K08736 MSH3; DNA mismatch repair protein MSH3
E 100725043 Msh6; LOW QUALITY PROTEIN: DNA mismatch repair protein Msh6 K08737 MSH6; DNA mismatch repair protein MSH6
D MutL homologs
E 100713513 Pms1; PMS1 protein homolog 1 isoform X1 K10864 PMS1; DNA mismatch repair protein PMS1
E 100717848 Mlh1; DNA mismatch repair protein Mlh1 isoform X2 K08734 MLH1; DNA mismatch repair protein MLH1
E 100726203 Pms2; mismatch repair endonuclease PMS2 K10858 PMS2; DNA mismatch repair protein PMS2
E 100735009 Mlh3; DNA mismatch repair protein Mlh3 isoform X1 K08739 MLH3; DNA mismatch repair protein MLH3
D DNA polymerase delta complex
E 100719673 Pold1; DNA polymerase delta catalytic subunit isoform X1 K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
E 100727561 Pold2; DNA polymerase delta subunit 2 isoform X1 K02328 POLD2; DNA polymerase delta subunit 2
E 100734598 Pold3; DNA polymerase delta subunit 3 isoform X1 K03504 POLD3; DNA polymerase delta subunit 3
E 100732830 Pold4; DNA polymerase delta subunit 4 isoform X1 K03505 POLD4; DNA polymerase delta subunit 4
D RPA (replication factor A)
E 100716820 Rpa1; replication protein A 70 kDa DNA-binding subunit K07466 RFA1; replication factor A1
E 100721250 Rpa2; replication protein A 32 kDa subunit K10739 RFA2; replication factor A2
E 100715065 Rpa3; replication protein A 14 kDa subunit K10740 RPA3; replication factor A3
D RFC (replication factor C)
E 100733981 Rfc1; replication factor C subunit 1 isoform X1 K10754 RFC1; replication factor C subunit 1
E 100713099 Rfc2; replication factor C subunit 2 K10755 RFC2_4; replication factor C subunit 2/4
E 100729757 Rfc4; replication factor C subunit 4 isoform X1 K10755 RFC2_4; replication factor C subunit 2/4
E 100723132 Rfc5; replication factor C subunit 5 isoform X1 K10756 RFC3_5; replication factor C subunit 3/5
E 100714795 Rfc3; replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
D Other MMR factors
E 100713865 Pcna; proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
E 100714964 Exo1; exonuclease 1 K10746 EXO1; exonuclease 1 [EC:3.1.-.-]
E 100720324 LOW QUALITY PROTEIN: putative high mobility group protein B1-like 1 K10802 HMGB1; high mobility group protein B1
E 106025160 Hmgb1; high mobility group protein B1 K10802 HMGB1; high mobility group protein B1
E 100734013 Lig1; DNA ligase 1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
E 100718975 Wdr76; WD repeat-containing protein 76 isoform X1 K24755 WDR76; WD repeat-containing protein 76
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D MRN(MRX) complex
E 100721147 Mre11; double-strand break repair protein MRE11 K10865 MRE11; double-strand break repair protein MRE11
E 100719847 Rad50; DNA repair protein RAD50 isoform X2 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
E 100715565 Nbn; nibrin isoform X1 K10867 NBN; nibrin
D BRCA1-core complex
E 100722339 Brca1; breast cancer type 1 susceptibility protein isoform X2 K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 100731860 Bard1; BRCA1-associated RING domain protein 1 isoform X1 K10683 BARD1; BRCA1-associated RING domain protein 1
D BRCA1-A complex
E 100722339 Brca1; breast cancer type 1 susceptibility protein isoform X2 K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 100721329 Abraxas1; BRCA1-A complex subunit Abraxas 1 isoform X2 K20774 FAM175A; BRCA1-A complex subunit Abraxas
E 100725402 Uimc1; BRCA1-A complex subunit RAP80 isoform X1 K20775 UIMC1; BRCA1-A complex subunit RAP80
E 100732454 Babam1; BRISC and BRCA1-A complex member 1 isoform X2 K20776 BABAM; BRISC and BRCA1-A complex member 1
E 100725666 Babam2; BRISC and BRCA1-A complex member 2 K12173 BRE; BRCA1-A complex subunit BRE
E 100719736 Brcc3; lys-63-specific deubiquitinase BRCC36 isoform X1 K11864 BRCC3; BRCA1/BRCA2-containing complex subunit 3 [EC:3.4.19.-]
D BRCA1-B complex
E 100722339 Brca1; breast cancer type 1 susceptibility protein isoform X2 K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 100729812 Brip1; LOW QUALITY PROTEIN: Fanconi anemia group J protein K15362 BRIP1; fanconi anemia group J protein [EC:5.6.2.3]
E 100721641 Topbp1; DNA topoisomerase 2-binding protein 1 K10728 TOPBP1; topoisomerase (DNA) II binding protein 1
D BRCA1-C complex
E 100722339 Brca1; breast cancer type 1 susceptibility protein isoform X2 K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 100719710 Rbbp8; DNA endonuclease RBBP8 isoform X1 K20773 RBBP8; DNA endonuclease RBBP8 [EC:3.1.-.-]
E 100721147 Mre11; double-strand break repair protein MRE11 K10865 MRE11; double-strand break repair protein MRE11
E 100719847 Rad50; DNA repair protein RAD50 isoform X2 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
E 100715565 Nbn; nibrin isoform X1 K10867 NBN; nibrin
D BRCA complex
E 100722339 Brca1; breast cancer type 1 susceptibility protein isoform X2 K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 100713136 Brca2; breast cancer type 2 susceptibility protein K08775 BRCA2; breast cancer 2 susceptibility protein
E 100721467 Palb2; partner and localizer of BRCA2 isoform X1 K10897 PALB2; partner and localizer of BRCA2
E 100716391 Rad51; DNA repair protein RAD51 homolog 1 isoform X1 K04482 RAD51; DNA repair protein RAD51
D RecA family proteins
E 100716391 Rad51; DNA repair protein RAD51 homolog 1 isoform X1 K04482 RAD51; DNA repair protein RAD51
E 100713111 Rad51b; DNA repair protein RAD51 homolog 2 K10869 RAD51L1; RAD51-like protein 1
E 100727310 Rad51c; DNA repair protein RAD51 homolog 3 K10870 RAD51L2; RAD51-like protein 2
E 100715410 Rad51d; DNA repair protein RAD51 homolog 4 K10871 RAD51L3; RAD51-like protein 3
E 100716725 Xrcc2; DNA repair protein XRCC2 isoform X2 K10879 XRCC2; DNA-repair protein XRCC2
E 100723056 Xrcc3; DNA repair protein XRCC3 K10880 XRCC3; DNA-repair protein XRCC3
D Rad52 family proteins
E 100729582 Rad52; DNA repair protein RAD52 homolog isoform X4 K10873 RAD52; DNA repair and recombination protein RAD52
E 100730442 Rdm1; RAD52 motif-containing protein 1 isoform X1 K10874 RDM1; RAD52 motif-containing protein 1
D Rad54 family proteins
E 100721109 Rad54l; DNA repair and recombination protein RAD54-like K10875 RAD54L; DNA repair and recombination protein RAD54 and RAD54-like protein [EC:5.6.2.-]
E 100720461 Rad54l2; helicase ARIP4 K10876 RAD54L2; RAD54-like protein 2 [EC:5.6.2.-]
E 100734409 Rad54b; DNA repair and recombination protein RAD54B K10877 RAD54B; DNA repair and recombination protein RAD54B [EC:5.6.2.-]
D RecQ family DNA helicases
E 100719692 Recql; ATP-dependent DNA helicase Q1 K10899 RECQL; ATP-dependent DNA helicase Q1 [EC:5.6.2.4]
E 100719896 Wrn; Werner syndrome ATP-dependent helicase isoform X1 K10900 WRN; werner syndrome ATP-dependent helicase [EC:5.6.2.4]
E 100732874 Blm; Bloom syndrome protein isoform X1 K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 100736086 Recql4; ATP-dependent DNA helicase Q4 isoform X2 K10730 RECQL4; ATP-dependent DNA helicase Q4 [EC:5.6.2.4]
E 100718156 Recql5; ATP-dependent DNA helicase Q5 isoform X1 K10902 RECQL5; ATP-dependent DNA helicase Q5 [EC:5.6.2.4]
D Bloom's syndrome complex (BTR)
E 100732874 Blm; Bloom syndrome protein isoform X1 K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 100734860 Top3b; DNA topoisomerase 3-beta-1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 100733021 Top3a; DNA topoisomerase 3-alpha isoform X1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 100724405 Rmi1; recQ-mediated genome instability protein 1 K10990 RMI1; RecQ-mediated genome instability protein 1
E 100729210 Rmi2; recQ-mediated genome instability protein 2 K15365 RMI2; RecQ-mediated genome instability protein 2
D RPA (replication factor A)
E 100716820 Rpa1; replication protein A 70 kDa DNA-binding subunit K07466 RFA1; replication factor A1
E 100721250 Rpa2; replication protein A 32 kDa subunit K10739 RFA2; replication factor A2
E 100715065 Rpa3; replication protein A 14 kDa subunit K10740 RPA3; replication factor A3
D Protein phosphatase 4
E 100730126 Ppp4c; serine/threonine-protein phosphatase 4 catalytic subunit isoform X1 K15423 PPP4C; serine/threonine-protein phosphatase 4 catalytic subunit [EC:3.1.3.16]
E 100712897 Ppp4r1; serine/threonine-protein phosphatase 4 regulatory subunit 1 K15424 PPP4R1; serine/threonine-protein phosphatase 4 regulatory subunit 1
E 100730377 Ppp4r2; serine/threonine-protein phosphatase 4 regulatory subunit 2 K15425 PPP4R2; serine/threonine-protein phosphatase 4 regulatory subunit 2
E 100714105 Ppp4r3b; serine/threonine-protein phosphatase 4 regulatory subunit 3B K17491 SMEK; protein phosphatase 4 regulatory subunit 3
E 100734400 Ppp4r4; serine/threonine-protein phosphatase 4 regulatory subunit 4 isoform X1 K15426 PPP4R4; serine/threonine-protein phosphatase 4 regulatory subunit 4
D AP-5 complex
E 100724643 Ap5b1; AP-5 complex subunit beta-1 K19022 AP5B1; AP-5 complex subunit beta-1
E 100727689 Ap5m1; AP-5 complex subunit mu-1 K19023 AP5M1; AP-5 complex subunit mu-1
E 100716570 Ap5s1; AP-5 complex subunit sigma-1 K19024 AP5S1; AP-5 complex subunit sigma-1
E 100731381 Ap5z1; AP-5 complex subunit zeta-1 isoform X2 K19025 AP5Z1; AP-5 complex subunit zeta-1
D SMC5-SMC6 complex
E 100731205 Smc5; structural maintenance of chromosomes protein 5 K22803 SMC5; structural maintenance of chromosomes protein 5
E 100721259 Smc6; structural maintenance of chromosomes protein 6 K22804 SMC6; structural maintenance of chromosomes protein 6
E 100718356 Fam84a; protein FAM84A K22805 FAM84A; protein FAM84A
E 100717062 LOW QUALITY PROTEIN: protein FAM84A-like K22805 FAM84A; protein FAM84A
E 100721287 Nsmce1; non-structural maintenance of chromosomes element 1 homolog isoform X2 K22817 NSMCE1; non-structural maintenance of chromosomes element 1 [EC:2.3.2.27]
E 100724833 Nsmce2; E3 SUMO-protein ligase NSE2 K22756 NSMCE2; E3 SUMO-protein ligase NSE2 [EC:2.3.2.-]
E 100718703 Nsmce3; non-structural maintenance of chromosomes element 3 homolog K22823 NSMCE3; non-structural maintenance of chromosomes element 3
E 100717059 Nsmce4a; non-structural maintenance of chromosomes element 4 homolog A K22825 NSMCE4; non-structural maintenance of chromosomes element 4
E 106028343 Eid3; LOW QUALITY PROTEIN: EP300-interacting inhibitor of differentiation 3 K22826 EID3; EP300-interacting inhibitor of differentiation 3
E 100721480 Slf1; SMC5-SMC6 complex localization factor protein 1 K26126 SLF1; SMC5-SMC6 complex localization factor protein 1
E 101787861 Slf2; SMC5-SMC6 complex localization factor protein 2 K26127 SLF2; SMC5-SMC6 complex localization factor protein 2
D Other HR factors
E 100732469 Eme1; crossover junction endonuclease EME1 isoform X4 K10882 EME1; crossover junction endonuclease EME1 [EC:3.1.22.-]
E 100729300 Eme2; probable crossover junction endonuclease EME2 isoform X1 K10883 EME2; crossover junction endonuclease EME2
E 100721998 Exd2; exonuclease 3'-5' domain-containing protein 2 K20777 EXD2; exonuclease 3'-5' domain-containing protein 2 [EC:3.1.11.1]
E 100732562 Mus81; crossover junction endonuclease MUS81 isoform X1 K08991 MUS81; crossover junction endonuclease MUS81 [EC:3.1.22.-]
E 100735574 Sem1; 26S proteasome complex subunit SEM1 K10881 SHFM1; 26 proteasome complex subunit DSS1
E 100717096 Swi5; DNA repair protein SWI5 homolog K10991 SWI5; DNA repair protein Swi5/Sae3
E 100721173 Sfr1; swi5-dependent recombination DNA repair protein 1 homolog K10992 SFR1; Swi5-dependent recombination DNA repair protein 1
E 100729022 Slx1a; structure-specific endonuclease subunit SLX1 isoform X1 K15078 SLX1; structure-specific endonuclease subunit SLX1 [EC:3.6.1.-]
E 100718161 Slx4; structure-specific endonuclease subunit SLX4 isoform X2 K10484 BTBD12; structure-specific endonuclease subunit SLX4 (BTB/POZ domain-containing protein 12)
E 100721538 Gen1; flap endonuclease GEN homolog 1 K15338 GEN1; holliday junction resolvase GEN1/YEN1 [EC:3.1.-.-]
E 100719807 Spg11; spatacsin K19026 SPG11; spatacsin
E 100719146 Zfyve26; zinc finger FYVE domain-containing protein 26 isoform X1 K19027 ZFYVE26; zinc finger FYVE domain-containing protein 26
E 100717794 Rad51ap1; RAD51-associated protein 1 K20778 RAD51AP1; RAD51-associated protein 1
E 100735226 Morf4l1; mortality factor 4-like protein 1 K11339 MORF4L1; mortality factor 4-like protein 1
E 100735451 Samhd1; deoxynucleoside triphosphate triphosphohydrolase SAMHD1 K22544 SAMHD1; deoxynucleoside triphosphate triphosphohydrolase SAMHD1 [EC:3.1.5.-]
E 100733752 Fignl1; fidgetin-like protein 1 K22766 FIGNL1; fidgetin-like protein 1 [EC:5.6.2.-]
E 100722611 Spidr; DNA repair-scaffolding protein isoform X1 K22806 SPIDR; DNA repair-scaffolding protein
E 100731546 Fam84b; protein FAM84B K22810 FAM84B; protein FAM84B
E 100731655 Brat1; BRCA1-associated ATM activator 1 isoform X1 K23112 BRAT1; BRCA1-associated ATM activator 1
E 100730151 CUNH21orf2; protein C21orf2 homolog isoform X1 K23456 CFAP410; cilla- and flagella-associated protein
E 100734288 Hdgfl2; hepatoma-derived growth factor-related protein 2 isoform X4 K25065 HDGFL2; hepatoma-derived growth factor-related protein 2
E 100721593 Zswim7; zinc finger SWIM domain-containing protein 7 K25770 ZSWIM7; zinc finger SWIM domain-containing protein 7
E 100725608 Swsap1; ATPase SWSAP1 K25771 SWSAP1; ATPase SWSAP1
E 100717364 Emsy; BRCA2-interacting transcriptional repressor EMSY isoform X1 K25790 EMSY; BRCA2-interacting transcriptional repressor EMSY
E 100724534 Hsf2bp; heat shock factor 2-binding protein isoform X1 K25791 HSF2BP; heat shock factor 2-binding protein
E 100734427 Mms22l; protein MMS22-like isoform X1 K26125 MMS22L; protein MMS22-like
E 100734969 Tonsl; tonsoku-like protein isoform X2 K09257 NFKBIL2; NF-kappa-B inhibitor-like protein 2
E 100730155 Bod1l1; LOW QUALITY PROTEIN: biorientation of chromosomes in cell division protein 1-like 1 K27262 BOD1L1; biorientation of chromosomes in cell division protein 1-like 1
E 100728642 Parpbp; PCNA-interacting partner K27412 PARPBP; PCNA-interacting partner
C NHEJ (non-homologous end-joining)
D DNA-PK complex
E 100717277 Xrcc6; X-ray repair cross-complementing protein 6 isoform X1 K10884 XRCC6; ATP-dependent DNA helicase 2 subunit 1
E 100728001 X-ray repair cross-complementing protein 5 isoform X2 K10885 XRCC5; ATP-dependent DNA helicase 2 subunit 2
E 100724826 Prkdc; DNA-dependent protein kinase catalytic subunit K06642 PRKDC; DNA-dependent protein kinase catalytic subunit [EC:2.7.11.1]
D MRX complex
E 100721147 Mre11; double-strand break repair protein MRE11 K10865 MRE11; double-strand break repair protein MRE11
E 100719847 Rad50; DNA repair protein RAD50 isoform X2 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
D DNA Ligase 4 complex
E 100719171 Lig4; DNA ligase 4 K10777 LIG4; DNA ligase 4 [EC:6.5.1.1]
E 100731158 Xrcc4; DNA repair protein XRCC4 isoform X2 K10886 XRCC4; DNA-repair protein XRCC4
E 100713065 Nhej1; non-homologous end-joining factor 1 isoform X2 K10980 NHEJ1; non-homologous end-joining factor 1
D X-family DNA polymerases
E 100729389 Poll; DNA polymerase lambda isoform X2 K03512 POLL; DNA polymerase lambda [EC:2.7.7.7 4.2.99.-]
E 100728400 Polm; LOW QUALITY PROTEIN: DNA-directed DNA/RNA polymerase mu K03513 POLM; DNA polymerase mu [EC:2.7.7.7]
E 100717998 Dntt; LOW QUALITY PROTEIN: DNA nucleotidylexotransferase K00977 DNTT; DNA nucleotidylexotransferase [EC:2.7.7.31]
E 100731356 Polb; LOW QUALITY PROTEIN: DNA polymerase beta K02330 POLB; DNA polymerase beta [EC:2.7.7.7 4.2.99.-]
D Other NHEJ factors
E 100722168 Aptx; aprataxin isoform X5 K10863 APTX; aprataxin [EC:3.6.1.70 3.6.1.71 3.6.1.72]
E 100729628 Aplf; aprataxin and PNK-like factor K13295 APLF; aprataxin and PNK-like factor [EC:3.1.-.-]
E 100716630 Dclre1c; protein artemis isoform X1 K10887 DCLRE1C; DNA cross-link repair 1C protein [EC:3.1.-.-]
E 100724093 Tdp2; tyrosyl-DNA phosphodiesterase 2 isoform X1 K19619 TDP2; tyrosyl-DNA phosphodiesterase 2 [EC:3.1.4.-]
E 100717339 Smchd1; structural maintenance of chromosomes flexible hinge domain-containing protein 1 K23113 SMCHD1; structural maintenance of chromosomes flexible hinge domain-containing protein 1
E 100715090 PWWP domain-containing protein MUM1-like K23386 PWWP3; PWWP domain-containing DNA repair factor 3
E 100715873 Mum1l1; PWWP domain-containing protein MUM1L1 K23386 PWWP3; PWWP domain-containing DNA repair factor 3
E 100723585 PWWP domain-containing protein MUM1L1-like K23386 PWWP3; PWWP domain-containing DNA repair factor 3
E 100734941 PWWP domain-containing protein MUM1 isoform X1 K23386 PWWP3; PWWP domain-containing DNA repair factor 3
E 100717666 Paxx; protein PAXX K25772 PAXX; protein PAXX
E 100722286 CUNH7orf49; cell cycle regulator of non-homologous end joining K26155 CYREN; cell cycle regulator of non-homologous end joining
E 100721018 Jmjd8; jmjC domain-containing protein 8 K25792 JMJD8; jumonji domain-containing protein 8
E 100733818 CUNH20orf196; uncharacterized protein C20orf196 homolog K26128 SHLD1; shieldin complex subunit 1
E 100722242 Fam35a; protein FAM35A isoform X1 K26129 SHLD2; shieldin complex subunit 2
C FA (Fanconi anemia) pathway
D FA core complex
E 100732330 Fanca; Fanconi anemia group A protein isoform X1 K10888 FANCA; fanconi anemia group A protein
E 100714814 Fancb; Fanconi anemia group B protein K10889 FANCB; fanconi anemia group B protein
E 100728880 Fancc; Fanconi anemia group C protein K10890 FANCC; fanconi anemia group C protein
E 100731486 Fance; Fanconi anemia group E protein isoform X1 K10892 FANCE; fanconi anemia group E protein
E 100728032 Fancf; LOW QUALITY PROTEIN: Fanconi anemia group F protein K10893 FANCF; fanconi anemia group F protein
E 100726393 Fancg; Fanconi anemia group G protein K10894 FANCG; fanconi anemia group G protein
E 100720230 Fancl; E3 ubiquitin-protein ligase FANCL isoform X1 K10606 FANCL; E3 ubiquitin-protein ligase FANCL [EC:2.3.2.27]
E 100715324 Fancm; LOW QUALITY PROTEIN: Fanconi anemia group M protein K10896 FANCM; fanconi anemia group M protein
E 100724279 Faap24; Fanconi anemia core complex-associated protein 24 isoform X2 K10898 FAAP24; fanconi anemia-associated protein
E 100732264 Faap100; Fanconi anemia core complex-associated protein 100 isoform X1 K10993 FAAP100; fanconi anemia core complex 100 kDa subunit
D FA core complex binding factors
E 100734567 Hes1; transcription factor HES-1 K06054 HES1; hairy and enhancer of split 1
E 100727121 Cenps; centromere protein S K11511 APITD1; centromere protein S
E 100715209 Cenpx; centromere protein X isoform X2 K15360 STRA13; centromere protein X
E 100730758 Ube2t; ubiquitin-conjugating enzyme E2 T isoform X1 K13960 UBE2T; ubiquitin-conjugating enzyme E2 T [EC:2.3.2.23]
D Bloom's syndrome complex (BTR)
E 100732874 Blm; Bloom syndrome protein isoform X1 K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 100734860 Top3b; DNA topoisomerase 3-beta-1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 100733021 Top3a; DNA topoisomerase 3-alpha isoform X1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 100724405 Rmi1; recQ-mediated genome instability protein 1 K10990 RMI1; RecQ-mediated genome instability protein 1
E 100729210 Rmi2; recQ-mediated genome instability protein 2 K15365 RMI2; RecQ-mediated genome instability protein 2
D FANCD2-I complex
E 100729511 Fancd2; Fanconi anemia group D2 protein isoform X1 K10891 FANCD2; fanconi anemia group D2 protein
E 100731127 Fanci; Fanconi anemia group I protein K10895 FANCI; fanconi anemia group I protein
D Downstream FA components
E 100722339 Brca1; breast cancer type 1 susceptibility protein isoform X2 K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 100713136 Brca2; breast cancer type 2 susceptibility protein K08775 BRCA2; breast cancer 2 susceptibility protein
E 100729812 Brip1; LOW QUALITY PROTEIN: Fanconi anemia group J protein K15362 BRIP1; fanconi anemia group J protein [EC:5.6.2.3]
E 100721467 Palb2; partner and localizer of BRCA2 isoform X1 K10897 PALB2; partner and localizer of BRCA2
D Other FA pathway factors
E 100716193 Fan1; LOW QUALITY PROTEIN: fanconi-associated nuclease 1 K15363 FAN1; fanconi-associated nuclease 1 [EC:3.1.21.- 3.1.4.1]
E 100716391 Rad51; DNA repair protein RAD51 homolog 1 isoform X1 K04482 RAD51; DNA repair protein RAD51
E 100727310 Rad51c; DNA repair protein RAD51 homolog 3 K10870 RAD51L2; RAD51-like protein 2
E 100728749 Telo2; telomere length regulation protein TEL2 homolog isoform X1 K11137 TELO2; telomere length regulation protein
E 100722039 Usp1; ubiquitin carboxyl-terminal hydrolase 1 K11832 USP1; ubiquitin carboxyl-terminal hydrolase 1 [EC:3.4.19.12]
E 100734781 Wdr48; WD repeat-containing protein 48 isoform X2 K15361 WDR48; WD repeat-containing protein 48
C Other DSBR factors
D Protein phosphatase 6
E 100731843 Ppp6c; serine/threonine-protein phosphatase 6 catalytic subunit K15498 PPP6C; serine/threonine-protein phosphatase 6 catalytic subunit [EC:3.1.3.16]
E 100713539 Ppp6r1; serine/threonine-protein phosphatase 6 regulatory subunit 1 isoform X2 K15499 PPP6R1; serine/threonine-protein phosphatase 6 regulatory subunit 1
E 100720382 Ppp6r2; serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X4 K15500 PPP6R2; serine/threonine-protein phosphatase 6 regulatory subunit 2
E 100728139 Ppp6r3; LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 6 regulatory subunit 3 K15501 PPP6R3; serine/threonine-protein phosphatase 6 regulatory subunit 3
E 100726446 Ankrd28; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A isoform X2 K15502 ANKRD28; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A
E 100723787 Ankrd44; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B K15503 ANKRD44; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B
E 100734004 Ankrd52; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C K15504 ANKRD52; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C
D Ubiquitin ligases
E 100725403 Rnf8; E3 ubiquitin-protein ligase RNF8 isoform X1 K10667 RNF8; E3 ubiquitin-protein ligase RNF8 [EC:2.3.2.27]
E 100723206 Rnf168; E3 ubiquitin-protein ligase RNF168 K20779 RNF168; E3 ubiquitin-protein ligase RNF168 [EC:2.3.2.31]
E 100712887 Rnf169; E3 ubiquitin-protein ligase RNF169 K20805 RNF169; E3 ubiquitin-protein ligase RNF169 [EC:2.3.2.31]
E 100731329 E3 ubiquitin-protein ligase HERC2 K10595 HERC2; E3 ubiquitin-protein ligase HERC2 [EC:2.3.2.26]
D Others
E 100733673 Wrap53; telomerase Cajal body protein 1 isoform X2 K23314 WRAP53; telomerase Cajal body protein 1
E 100730098 Tprn; LOW QUALITY PROTEIN: taperin K24164 TPRN; taperin
E 100715413 Zcwpw1; zinc finger CW-type PWWP domain protein 1 K24688 ZCWPW1; zinc finger CW-type PWWP domain protein 1
E 100735925 Wdr70; WD repeat-containing protein 70 isoform X1 K24752 WDR70; WD repeat-containing protein 70
E 100718975 Wdr76; WD repeat-containing protein 76 isoform X1 K24755 WDR76; WD repeat-containing protein 76
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
D 100732400 Polh; DNA polymerase eta K03509 POLH; DNA polymerase eta [EC:2.7.7.7]
D 100734922 Poli; DNA polymerase iota isoform X1 K03510 POLI; DNA polymerase iota [EC:2.7.7.7]
D 100726233 Polk; DNA polymerase kappa K03511 POLK; DNA polymerase kappa [EC:2.7.7.7]
D 100725580 Rev1; DNA repair protein REV1 isoform X1 K03515 REV1; DNA repair protein REV1 [EC:2.7.7.-]
C B-family DNA polymerases
D 101787733 Rev3l; LOW QUALITY PROTEIN: DNA polymerase zeta catalytic subunit K02350 REV3L; DNA polymerase zeta [EC:2.7.7.7]
C A-family DNA polymerase
D 100731110 Poln; DNA polymerase nu isoform X1 K16618 POLN; DNA polymerase nu [EC:2.7.7.7]
C Rad6 epistasis group
D 100715223 Ube2a; ubiquitin-conjugating enzyme E2 A K10573 UBE2A; ubiquitin-conjugating enzyme E2 A [EC:2.3.2.23]
D 100713340 Ube2b; ubiquitin-conjugating enzyme E2 B K10574 UBE2B; ubiquitin-conjugating enzyme E2 B [EC:2.3.2.23]
D 100720939 Rad18; E3 ubiquitin-protein ligase RAD18 K10627 RAD18; E3 ubiquitin-protein ligase RAD18 [EC:2.3.2.27]
D 100716292 Hltf; helicase-like transcription factor isoform X2 K15711 SMARCA3; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A3 [EC:5.6.2. 2.3.2.27]
D 106024974 Ube2v1; ubiquitin-conjugating enzyme E2 variant 1 isoform X3 K10704 UBE2V; ubiquitin-conjugating enzyme E2 variant
D 100721778 Ube2v2; ubiquitin-conjugating enzyme E2 variant 2 isoform X1 K10704 UBE2V; ubiquitin-conjugating enzyme E2 variant
D 100727315 ubiquitin-conjugating enzyme E2 N K10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23]
D 100726684 Ube2n; ubiquitin-conjugating enzyme E2 N K10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23]
D 106026468 ubiquitin-conjugating enzyme E2 N-like K10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23]
C Other TLS factors
D 100713865 Pcna; proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
D 100728642 Parpbp; PCNA-interacting partner K27412 PARPBP; PCNA-interacting partner
D 100726031 Sprtn; sprT-like domain-containing protein Spartan K24051 SPRTN; SprT-like domain-contaning protein Spartan
D 101788403 Gcna; LOW QUALITY PROTEIN: acidic repeat-containing protein K26957 GCNA; germ cell nuclear acidic protein
B Check point factors
C Rad9-Hus1-Rad1 complex
D 100721417 Rad9a; cell cycle checkpoint control protein RAD9A K10994 RAD9A; cell cycle checkpoint control protein RAD9A [EC:3.1.11.2]
D 100717993 Rad9b; cell cycle checkpoint control protein RAD9B K10995 RAD9B; cell cycle checkpoint control protein RAD9B
D 100713541 Hus1; checkpoint protein HUS1 isoform X1 K10903 HUS1; HUS1 checkpoint protein
D 100714852 Rad1; cell cycle checkpoint protein RAD1 K02830 HRAD1; cell cycle checkpoint protein [EC:3.1.11.2]
C HRAD17(Rad24)-RFC complex
D 100726505 Rad17; cell cycle checkpoint protein RAD17 K06662 HRAD17; cell cycle checkpoint protein
D 100713099 Rfc2; replication factor C subunit 2 K10755 RFC2_4; replication factor C subunit 2/4
D 100729757 Rfc4; replication factor C subunit 4 isoform X1 K10755 RFC2_4; replication factor C subunit 2/4
D 100723132 Rfc5; replication factor C subunit 5 isoform X1 K10756 RFC3_5; replication factor C subunit 3/5
D 100714795 Rfc3; replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
C Rad17-Mec3-Ddc1 complex
D 100714852 Rad1; cell cycle checkpoint protein RAD1 K02830 HRAD1; cell cycle checkpoint protein [EC:3.1.11.2]
C FPC (fork protection complex)
D 100732412 Timeless; protein timeless homolog K10997 TIMELESS; replication fork protection complex subunit TIMELESS/Tof1/Swi1
D 100719663 Tipin; TIMELESS-interacting protein K10998 TIPIN; replication fork protection complex subunit TIPIN/Csm3/Swi3
D 100732670 Clspn; claspin K25773 CLSPN; claspin
D 100717396 LOW QUALITY PROTEIN: claspin-like K25773 CLSPN; claspin
C Triple T complex
D 100728749 Telo2; telomere length regulation protein TEL2 homolog isoform X1 K11137 TELO2; telomere length regulation protein
D 100730540 Tti1; TELO2-interacting protein 1 homolog isoform X1 K20403 TTI1; TELO2-interacting protein 1
D 100721725 Tti2; LOW QUALITY PROTEIN: TELO2-interacting protein 2 K23115 TTI2; TELO2-interacting protein 2
C BAG6-UBL4A-GET4 complex
D 100721819 Bag6; large proline-rich protein BAG6 isoform X5 K23390 BAG6; large proline-rich protein BAG6
D 100723318 Ubl4a; ubiquitin-like protein 4A K23388 UBL4; ubiquitin-like protein 4
D 100720756 Ubl4b; ubiquitin-like protein 4B K23388 UBL4; ubiquitin-like protein 4
D 100734815 Get4; Golgi to ER traffic protein 4 homolog isoform X4 K23387 GET4; golgi to ER traffic protein 4
C Other check point factors
D 100732693 Atr; serine/threonine-protein kinase ATR K06640 ATR; serine/threonine-protein kinase ATR [EC:2.7.11.1]
D 100725412 ATR-interacting protein isoform X2 K10905 ATRIP; ATR interacting protein
D 100717983 Atm; serine-protein kinase ATM K04728 ATM; serine-protein kinase ATM [EC:2.7.11.1]
D 100379269 Tp53; cellular tumor antigen p53 K04451 TP53; tumor protein p53
D 100719613 Chek1; serine/threonine-protein kinase Chk1 K02216 CHEK1; serine/threonine-protein kinase CHEK1 [EC:2.7.11.1]
D 100727440 Chek2; serine/threonine-protein kinase Chk2 isoform X2 K06641 CHEK2; serine/threonine-protein kinase CHEK2 [EC:2.7.11.1]
D 100721008 Cdc25a; M-phase inducer phosphatase 1 isoform X1 K06645 CDC25A; M-phase inducer phosphatase 1 [EC:3.1.3.48]
D 100716851 Cdc25b; LOW QUALITY PROTEIN: M-phase inducer phosphatase 2 K05866 CDC25B; M-phase inducer phosphatase 2 [EC:3.1.3.48]
D 100727182 Ywhaz; 14-3-3 protein zeta/delta K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
D 100733198 Ywhaq; 14-3-3 protein theta K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
D 100715125 Ywhab; 14-3-3 protein beta/alpha K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
D 100725300 Ywhag; 14-3-3 protein gamma K16198 YWHAG_H; 14-3-3 protein gamma/eta
D 100728374 Ywhah; 14-3-3 protein eta K16198 YWHAG_H; 14-3-3 protein gamma/eta
D 100714396 Ywhae; 14-3-3 protein epsilon isoform X1 K06630 YWHAE; 14-3-3 protein epsilon
D 100726158 Nav2; neuron navigator 2 K19483 NAV2; neuron navigator 2 [EC:5.6.2.4]
D 100726821 Wee1; LOW QUALITY PROTEIN: wee1-like protein kinase K06632 WEE1; wee1-like protein kinase [EC:2.7.11.1]
D 100717213 Wee2; wee1-like protein kinase 2 K06632 WEE1; wee1-like protein kinase [EC:2.7.11.1]
D 100731177 Per1; period circadian protein homolog 1 isoform X1 K21944 PER1; period circadian protein 1
D 100713579 Per2; period circadian protein homolog 2 isoform X1 K02633 PER2; period circadian protein 2
D 100731201 Per3; LOW QUALITY PROTEIN: period circadian protein homolog 3 K21945 PER3; period circadian protein 3
D 100721744 Mdc1; mediator of DNA damage checkpoint protein 1 isoform X1 K20780 MDC1; mediator of DNA damage checkpoint protein 1
D 100718763 Pls3; LOW QUALITY PROTEIN: plastin-3 K17336 PLS3; plastin-3
D 100731952 Aen; apoptosis-enhancing nuclease K18340 AEN; apoptosis-enhancing nuclease [EC:3.1.-.-]
D 100722765 Plk3; serine/threonine-protein kinase PLK3 K08862 PLK3; polo-like kinase 3 [EC:2.7.11.21]
D 100712681 Plk5; inactive serine/threonine-protein kinase PLK5 K19596 PLK5; inactive serine/threonine-protein kinase PLK5
D 100726652 Nek1; serine/threonine-protein kinase Nek1 K08857 NEK1_4_5; serine/threonine-protein kinase Nek1/4/5 [EC:2.7.11.1]
D 100727641 Nek4; serine/threonine-protein kinase Nek4 isoform X1 K08857 NEK1_4_5; serine/threonine-protein kinase Nek1/4/5 [EC:2.7.11.1]
D 100714272 Nek10; serine/threonine-protein kinase Nek10 K20879 NEK10; serine/threonine-protein kinase Nek10 [EC:2.7.11.1]
D 100718145 Nek11; serine/threonine-protein kinase Nek11 K20880 NEK11; serine/threonine-protein kinase Nek11 [EC:2.7.11.1]
D 100726345 Donson; protein downstream neighbor of Son isoform X1 K22422 DONSON; protein downstream neighbor of Son
D 100720189 Kank2; KN motif and ankyrin repeat domain-containing protein 2 isoform X2 K22808 KANK; KN motif and ankyrin repeat domain-containing protein
D 100713417 Kank3; KN motif and ankyrin repeat domain-containing protein 3 K22808 KANK; KN motif and ankyrin repeat domain-containing protein
D 100727320 Kank1; KN motif and ankyrin repeat domain-containing protein 1 isoform X1 K22808 KANK; KN motif and ankyrin repeat domain-containing protein
D 100729968 Kank4; KN motif and ankyrin repeat domain-containing protein 4 K22808 KANK; KN motif and ankyrin repeat domain-containing protein
D 101787858 Klln; killin K23389 KLLN; killin
D 100723062 Chmp4c; charged multivesicular body protein 4c K24782 CHMP4C; charged multivesicular body protein 4C
D 100724580 Vps4a; vacuolar protein sorting-associated protein 4A K12196 VPS4; vacuolar protein-sorting-associated protein 4
D 100730380 Vps4b; vacuolar protein sorting-associated protein 4B K12196 VPS4; vacuolar protein-sorting-associated protein 4
D 100717676 Zfyve19; abscission/NoCut checkpoint regulator isoform X3 K24778 ZFYVE19; abscission/NoCut checkpoint regulator
D 100735791 Sde2; replication stress response regulator SDE2 K25059 SDE2; replication stress response regulator SDE2
D 100722675 replication stress response regulator SDE2-like K25059 SDE2; replication stress response regulator SDE2
B Other factors with a suspected DNA repair function
C DNA polymerases
D 100716540 Polq; DNA polymerase theta K02349 POLQ; DNA polymerase theta [EC:2.7.7.7]
D 100726753 Mybbp1a; myb-binding protein 1A K02331 POL5; DNA polymerase phi [EC:2.7.7.7]
D 100721241 Primpol; DNA-directed primase/polymerase protein isoform X1 K22761 PRIMPOL; DNA-directed primase/polymerase protein [EC:2.7.7.102 2.7.7.7]
C Nucleases
D 100714260 Trex2; three prime repair exonuclease 2 K10791 TREX2; three prime repair exonuclease 2 [EC:3.1.11.2]
D 100723290 Dclre1a; LOW QUALITY PROTEIN: DNA cross-link repair 1A protein K15340 DCLRE1A; DNA cross-link repair 1A protein
D 100729313 Dclre1b; 5' exonuclease Apollo K15341 DCLRE1B; DNA cross-link repair 1B protein [EC:3.1.-.-]
D 100721377 Exo5; exonuclease V isoform X2 K17815 EXO5; exonuclease V [EC:3.1.-.-]
D 100733861 Endov; endonuclease V K21813 ENDOV; endonuclease V [EC:3.1.26.-]
D 100732438 Zranb3; DNA annealing helicase and endonuclease ZRANB3 isoform X1 K25861 ZRANB3; DNA annealing helicase and endonuclease ZRANB3 [EC:5.6.2.- 3.1.-.-]
D 100731908 Ankle1; ankyrin repeat and LEM domain-containing protein 1 K21411 ANKLE1; ankyrin repeat and LEM domain-containing protein 1
C Helicases
D 100721608 Helq; helicase POLQ-like isoform X1 K19178 HELQ; POLQ-like helicase [EC:5.6.2.4]
D 100728605 Ercc6l2; DNA excision repair protein ERCC-6-like 2 isoform X1 K20098 ERCC6L2; DNA excision repair protein ERCC-6-like 2 [EC:5.6.2.-]
C PSO4 complex
D 100722057 Prpf19; pre-mRNA-processing factor 19 K10599 PRPF19; pre-mRNA-processing factor 19 [EC:2.3.2.27]
D 100729105 Cdc5l; cell division cycle 5-like protein K12860 CDC5L; pre-mRNA-splicing factor CDC5/CEF1
D 100720302 Bcas2; pre-mRNA-splicing factor SPF27 K12861 BCAS2; pre-mRNA-splicing factor SPF27
D 100722659 Plrg1; pleiotropic regulator 1 isoform X1 K12862 PLRG1; pleiotropic regulator 1
C Modulation of nucleotide pools
D 100714886 Nudt15; nucleotide triphosphate diphosphatase NUDT15 K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D 106025117 nucleotide triphosphate diphosphatase NUDT15 K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D 100730917 Nudt1; 7,8-dihydro-8-oxoguanine triphosphatase K17816 NUDT1; 8-oxo-dGTP diphosphatase / 2-hydroxy-dATP diphosphatase [EC:3.6.1.55 3.6.1.56]
D 100727909 Nudt18; 8-oxo-dGDP phosphatase NUDT18 K17817 NUDT18; 8-oxo-dGDP phosphatase [EC:3.6.1.58]
D 100717103 Dut; deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial isoform X1 K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 100728488 Rrm1; ribonucleoside-diphosphate reductase large subunit K10807 RRM1; ribonucleoside-diphosphate reductase subunit M1 [EC:1.17.4.1]
D 111754150 LOW QUALITY PROTEIN: ribonucleoside-diphosphate reductase large subunit-like K10807 RRM1; ribonucleoside-diphosphate reductase subunit M1 [EC:1.17.4.1]
D 100715474 Rrm2; ribonucleoside-diphosphate reductase subunit M2 K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]
D 100715485 Rrm2b; ribonucleoside-diphosphate reductase subunit M2 B isoform X1 K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]
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AProkaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D 100733185 Mgmt; methylated-DNA--protein-cysteine methyltransferase K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
C BER (base exicision repair)
D DNA glycosylases
E 100730581 Ung; uracil-DNA glycosylase K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E 100724319 Smug1; single-strand selective monofunctional uracil DNA glycosylase isoform X1 K10800 SMUG1; single-strand selective monofunctional uracil DNA glycosylase [EC:3.2.2.-]
E 100723877 Mutyh; adenine DNA glycosylase isoform X1 K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
E 100732333 Nthl1; endonuclease III-like protein 1 isoform X2 K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
D RecJ
D DNA ligase
D DNA polymerase I
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase complex (RNAP)
E TRCF (transcription-repair coupling factor)
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
D Molecular matchmaker
D Strand discrimination factor
D DNA exonucleases
D DNA polymerase III holoenzyme
D DNA ligase
D Other MMR factors
E 100716942 Ssbp1; single-stranded DNA-binding protein, mitochondrial K03111 ssb; single-strand DNA-binding protein
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D RecBC pathway proteins
D RecFOR pathway proteins
D AddAB pathway proteins
D Other HR factor
D Archaeal homologous recombinant proteins
C NHEJ (non-homologous end-joining)
D Two-component NHEJ DNA repair complex
D SHIIR (short-homology-independent illegitimate recombination)
E Facilitator
E Supressor
D SHDIR (short-homology-dependent illegitimate recombination)
E RecET pathway
E Facilitator
E Supressor
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
C Other SOS response factors
D 100716942 Ssbp1; single-stranded DNA-binding protein, mitochondrial K03111 ssb; single-strand DNA-binding protein
B Other factors with a suspected DNA repair function
C DNA polymerase
C DNA helicases
C Modulation of nucleotide pools
D 100714886 Nudt15; nucleotide triphosphate diphosphatase NUDT15 K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D 106025117 nucleotide triphosphate diphosphatase NUDT15 K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D 100717103 Dut; deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial isoform X1 K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
C Others
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: March 29, 2024