+F Repair protein KO
#
DNA Repair and Recombination Proteins - Magallana gigas (Pacific oyster)
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AEukaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D 105328756 methylated-DNA--protein-cysteine methyltransferase K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
D 105340036 alpha-ketoglutarate-dependent dioxygenase alkB homolog 3 K10860 ALKBH3; mRNA N1-methyladenine demethylase [EC:1.14.11.54]
D 105326317 activating signal cointegrator 1 complex subunit 3 isoform X1 K18663 ASCC3; activating signal cointegrator complex subunit 3 [EC:5.6.2.4]
D 105325072 deoxyribodipyrimidine photo-lyase K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]
C BER (base exicision repair)
D DNA glycosylases
E 105319857 uracil-DNA glycosylase 2 K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E 105346809 uracil-DNA glycosylase isoform X1 K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E 105335536 cyclin-O K10861 UDG2; uracil-DNA glycosylase 2 [EC:3.2.2.-]
E 105344766 uncharacterized protein LOC105344766 K20813 TDG; thymine-DNA glycosylase [EC:3.2.2.29]
E 105335077 putative 3-methyladenine DNA glycosylase isoform X1 K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]
E 105329457 adenine DNA glycosylase K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
E 105342553 uncharacterized protein LOC105342553 K10801 MBD4; methyl-CpG-binding domain protein 4 [EC:3.2.2.-]
E 105334924 N-glycosylase/DNA lyase isoform X2 K03660 OGG1; N-glycosylase/DNA lyase [EC:3.2.2.- 4.2.99.18]
E 105321538 endonuclease 8-like 1 isoform X1 K10567 NEIL1; endonuclease VIII-like 1 [EC:3.2.2.- 4.2.99.18]
E 105329222 endonuclease 8-like 3 K10569 NEIL3; endonuclease VIII-like 3 [EC:3.2.2.- 4.2.99.18]
E 117684019 endonuclease 8-like 3 isoform X1 K10569 NEIL3; endonuclease VIII-like 3 [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
E 105323590 exodeoxyribonuclease K10771 APEX1; AP endonuclease 1 [EC:3.1.11.2]
E 105342546 DNA-(apurinic or apyrimidinic site) lyase 2 K10772 APEX2; AP endonuclease 2 [EC:3.1.11.2]
D Long Patch-BER factors
E DNA polymerase delta complex
F 105322395 DNA polymerase delta catalytic subunit K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
F 105320389 DNA polymerase delta subunit 2 K02328 POLD2; DNA polymerase delta subunit 2
F 105343553 DNA polymerase delta subunit 3 isoform X1 K03504 POLD3; DNA polymerase delta subunit 3
F 105347002 DNA polymerase delta subunit 4 K03505 POLD4; DNA polymerase delta subunit 4
E DNA polymerase epsilon complex
F 105328709 DNA polymerase epsilon catalytic subunit A K02324 POLE; DNA polymerase epsilon subunit 1 [EC:2.7.7.7]
F 117689398 DNA polymerase epsilon subunit 2-like K02325 POLE2; DNA polymerase epsilon subunit 2 [EC:2.7.7.7]
F 105344133 DNA polymerase epsilon subunit 2 K02325 POLE2; DNA polymerase epsilon subunit 2 [EC:2.7.7.7]
F 105331310 DNA polymerase epsilon subunit 3 K02326 POLE3; DNA polymerase epsilon subunit 3 [EC:2.7.7.7]
E 105341104 proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
E 105322124 flap endonuclease 1 K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
E 105320057 DNA ligase 1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
D Short Patch-BER factors
E 105341699 DNA polymerase beta K02330 POLB; DNA polymerase beta [EC:2.7.7.7 4.2.99.-]
E 105343161 DNA repair protein XRCC1 K10803 XRCC1; DNA-repair protein XRCC1
E 105337784 uncharacterized protein LOC105337784 K10803 XRCC1; DNA-repair protein XRCC1
E 105333252 DNA ligase 3 isoform X1 K10776 LIG3; DNA ligase 3 [EC:6.5.1.1]
D Other BER factors
E 105325733 tyrosyl-DNA phosphodiesterase 1 K10862 TDP1; tyrosyl-DNA phosphodiesterase 1 [EC:3.1.4.-]
E 105322078 aprataxin isoform X3 K10863 APTX; aprataxin [EC:3.6.1.70 3.6.1.71 3.6.1.72]
E 105336765 aprataxin and PNK-like factor isoform X1 K13295 APLF; aprataxin and PNK-like factor [EC:3.1.-.-]
E 105322855 bifunctional polynucleotide phosphatase/kinase K08073 PNKP; bifunctional polynucleotide phosphatase/kinase [EC:3.1.3.32 2.7.1.78]
E 105340735 poly [ADP-ribose] polymerase 1 K08073 PNKP; bifunctional polynucleotide phosphatase/kinase [EC:3.1.3.32 2.7.1.78]
E 105326713 uncharacterized protein F21D5.5 K08073 PNKP; bifunctional polynucleotide phosphatase/kinase [EC:3.1.3.32 2.7.1.78]
E 105329085 high mobility group-T protein K10802 HMGB1; high mobility group protein B1
E 105344137 DNA polymerase lambda isoform X1 K03512 POLL; DNA polymerase lambda [EC:2.7.7.7 4.2.99.-]
E 105327492 poly [ADP-ribose] polymerase 1 K24070 PARP1; poly [ADP-ribose] polymerase 1 [EC:2.4.2.30]
E 105339444 poly [ADP-ribose] polymerase 2 K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
E 105321916 protein mono-ADP-ribosyltransferase PARP4 isoform X1 K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
E 105348700 protein mono-ADP-ribosyltransferase PARP4 isoform X1 K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
E 105344144 protein mono-ADP-ribosyltransferase PARP3 K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
E 117692790 LOW QUALITY PROTEIN: poly [ADP-ribose] polymerase 2-like K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
E 105343122 uncharacterized protein LOC105343122 isoform X1 K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E XPC-HR23B-CETN2 complex
F 105344772 DNA repair protein complementing XP-C cells isoform X1 K10838 XPC; xeroderma pigmentosum group C-complementing protein
F 105347475 UV excision repair protein RAD23 homolog B K10839 RAD23; UV excision repair protein RAD23
F 105341222 caltractin K10840 CETN2; centrin-2
F 105331093 caltractin-like isoform X1 K10840 CETN2; centrin-2
F 117681840 caltractin K10840 CETN2; centrin-2
F 105328266 calmodulin-like protein 30 K10840 CETN2; centrin-2
E Cul4-DDB2 complex
F 105317988 E3 ubiquitin-protein ligase RBX1 K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
F 105322898 cullin-4A-like K10609 CUL4; cullin 4
F 105339796 DNA damage-binding protein 1 K10610 DDB1; DNA damage-binding protein 1
F 105347658 DNA damage-binding protein 2-like isoform X1 K10140 DDB2; DNA damage-binding protein 2
E NER4 complex
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase II complex
F 105344236 DNA-directed RNA polymerase II subunit RPB1 K03006 RPB1; DNA-directed RNA polymerase II subunit RPB1 [EC:2.7.7.6]
F 117685579 DNA-directed RNA polymerase II subunit RPB2-like K03010 RPB2; DNA-directed RNA polymerase II subunit RPB2 [EC:2.7.7.6]
F 105343101 DNA-directed RNA polymerase II subunit RPB2 isoform X1 K03010 RPB2; DNA-directed RNA polymerase II subunit RPB2 [EC:2.7.7.6]
F 105321855 DNA-directed RNA polymerase II subunit RPB3 K03011 RPB3; DNA-directed RNA polymerase II subunit RPB3
F 105317502 DNA-directed RNA polymerase II subunit RPB4 K03012 RPB4; DNA-directed RNA polymerase II subunit RPB4
F 105330308 DNA-directed RNA polymerases I, II, and III subunit RPABC1 isoform X1 K03013 RPABC1; DNA-directed RNA polymerases I, II, and III subunit RPABC1
F 105336503 DNA-directed RNA polymerases I, II, and III subunit RPABC2 K03014 RPABC2; DNA-directed RNA polymerases I, II, and III subunit RPABC2
F 105319613 DNA-directed RNA polymerase II subunit RPB7 K03015 RPB7; DNA-directed RNA polymerase II subunit RPB7
F 105330854 DNA-directed RNA polymerases I, II, and III subunit RPABC3 K03016 RPABC3; DNA-directed RNA polymerases I, II, and III subunit RPABC3
F 105329337 DNA-directed RNA polymerase II subunit RPB9 K03017 RPB9; DNA-directed RNA polymerase II subunit RPB9
F 105338495 DNA-directed RNA polymerase II subunit RPB11-a K03008 RPB11; DNA-directed RNA polymerase II subunit RPB11
E Cul4-CSA complex
F 105317988 E3 ubiquitin-protein ligase RBX1 K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
F 105322898 cullin-4A-like K10609 CUL4; cullin 4
F 105339796 DNA damage-binding protein 1 K10610 DDB1; DNA damage-binding protein 1
F 105346737 DNA excision repair protein ERCC-8 K10570 ERCC8; DNA excision repair protein ERCC-8
E Other TCR factor
F 105343351 DNA excision repair protein ERCC-6 isoform X1 K10841 ERCC6; DNA excision repair protein ERCC-6
F 105325363 UV-stimulated scaffold protein A isoform X1 K23720 UVSSA; UV-stimulated scaffold protein A
F 105334578 transcription elongation factor 1 homolog isoform X1 K25829 ELOF1; transcription elongation factor 1
D TFIIH complex
E 105320807 general transcription and DNA repair factor IIH helicase subunit XPB isoform X1 K10843 ERCC3; DNA excision repair protein ERCC-3 [EC:5.6.2.4]
E 105327986 general transcription and DNA repair factor IIH helicase subunit XPD-like K10844 ERCC2; DNA excision repair protein ERCC-2 [EC:5.6.2.3]
E 105342019 general transcription factor IIH subunit 1 K03141 TFIIH1; transcription initiation factor TFIIH subunit 1
E 105345292 general transcription factor IIH subunit 2 K03142 TFIIH2; transcription initiation factor TFIIH subunit 2
E 105343120 general transcription factor IIH subunit 3 isoform X1 K03143 TFIIH3; transcription initiation factor TFIIH subunit 3
E 105336692 general transcription factor IIH subunit 4 K03144 TFIIH4; transcription initiation factor TFIIH subunit 4
E 117681418 general transcription factor IIH subunit 4-like K03144 TFIIH4; transcription initiation factor TFIIH subunit 4
E 105317788 cyclin-dependent kinase 7 K02202 CDK7; cyclin-dependent kinase 7 [EC:2.7.11.22 2.7.11.23]
E 105333009 cyclin-H-like K06634 CCNH; cyclin H
E 105330271 CDK-activating kinase assembly factor MAT1 K10842 MNAT1; CDK-activating kinase assembly factor MAT1
D RPA (replication factor A)
E 105335600 replication protein A 70 kDa DNA-binding subunit isoform X1 K07466 RFA1; replication factor A1
E 105338480 replication protein A 32 kDa subunit-A K10739 RFA2; replication factor A2
E 105342471 replication protein A 14 kDa subunit K10740 RPA3; replication factor A3
D Other NER factors
E 105335201 DNA repair protein complementing XP-A cells homolog K10847 XPA; DNA-repair protein complementing XP-A cells
E 105328421 DNA excision repair protein ERCC-1-like isoform X1 K10849 ERCC1; DNA excision repair protein ERCC-1
E 105328848 DNA repair endonuclease XPF K10848 ERCC4; DNA excision repair protein ERCC-4 [EC:3.1.-.-]
E 105334251 DNA repair protein complementing XP-G cells K10846 ERCC5; DNA excision repair protein ERCC-5
E 105320057 DNA ligase 1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
E 105318909 MMS19 nucleotide excision repair protein homolog K15075 MET18; DNA repair/transcription protein MET18/MMS19
E 105342092 cullin-3-B K03869 CUL3; cullin 3
E 105336504 cullin-5 K10612 CUL5; cullin 5
E 109620149 elongin-C K03872 ELOC; elongin-C
E 105318798 elongin-B K03873 ELOB; elongin-B
E 105320773 transcription elongation factor B polypeptide 3 K15076 ELOA; elongin-A
E 105342042 protein lingerer isoform X1 K26545 UBAP2; ubiquitin-associated protein 2
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
E 105335553 DNA mismatch repair protein Msh2 K08735 MSH2; DNA mismatch repair protein MSH2
E 105319347 DNA mismatch repair protein Msh3 isoform X1 K08736 MSH3; DNA mismatch repair protein MSH3
E 105344641 DNA mismatch repair protein Msh6 isoform X1 K08737 MSH6; DNA mismatch repair protein MSH6
D MutL homologs
E 105328453 PMS1 protein homolog 1 isoform X1 K10864 PMS1; DNA mismatch repair protein PMS1
E 105342900 DNA mismatch repair protein Mlh1 isoform X1 K08734 MLH1; DNA mismatch repair protein MLH1
E 105321188 mismatch repair endonuclease PMS2 isoform X1 K10858 PMS2; DNA mismatch repair protein PMS2
E 105327244 uncharacterized protein LOC105327244 K08739 MLH3; DNA mismatch repair protein MLH3
D DNA polymerase delta complex
E 105322395 DNA polymerase delta catalytic subunit K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
E 105320389 DNA polymerase delta subunit 2 K02328 POLD2; DNA polymerase delta subunit 2
E 105343553 DNA polymerase delta subunit 3 isoform X1 K03504 POLD3; DNA polymerase delta subunit 3
E 105347002 DNA polymerase delta subunit 4 K03505 POLD4; DNA polymerase delta subunit 4
D RPA (replication factor A)
E 105335600 replication protein A 70 kDa DNA-binding subunit isoform X1 K07466 RFA1; replication factor A1
E 105338480 replication protein A 32 kDa subunit-A K10739 RFA2; replication factor A2
E 105342471 replication protein A 14 kDa subunit K10740 RPA3; replication factor A3
D RFC (replication factor C)
E 105319440 replication factor C subunit 1 isoform X1 K10754 RFC1; replication factor C subunit 1
E 105317478 replication factor C subunit 2 K10755 RFC2_4; replication factor C subunit 2/4
E 105332688 replication factor C subunit 4 K10755 RFC2_4; replication factor C subunit 2/4
E 105332020 replication factor C subunit 5 K10756 RFC3_5; replication factor C subunit 3/5
E 105339014 replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
D Other MMR factors
E 105341104 proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
E 105348164 exonuclease 1 K10746 EXO1; exonuclease 1 [EC:3.1.-.-]
E 105329085 high mobility group-T protein K10802 HMGB1; high mobility group protein B1
E 105320057 DNA ligase 1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
E 105319435 WD repeat-containing protein 76 K24755 WDR76; WD repeat-containing protein 76
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D MRN(MRX) complex
E 117684366 double-strand break repair protein MRE11-like K10865 MRE11; double-strand break repair protein MRE11
E 105348988 LOW QUALITY PROTEIN: double-strand break repair protein MRE11 K10865 MRE11; double-strand break repair protein MRE11
E 105348735 DNA repair protein RAD50 isoform X1 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
E 105327116 nibrin isoform X2 K10867 NBN; nibrin
D BRCA1-core complex
E 105324607 BRCA1-associated RING domain protein 1 isoform X1 K10683 BARD1; BRCA1-associated RING domain protein 1
D BRCA1-A complex
E 105344222 BRISC complex subunit Abraxas 2 K20774 FAM175A; BRCA1-A complex subunit Abraxas
E 105326152 BRISC and BRCA1-A complex member 1 K20776 BABAM; BRISC and BRCA1-A complex member 1
E 105331437 BRISC and BRCA1-A complex member 2 K12173 BRE; BRCA1-A complex subunit BRE
E 105335265 lys-63-specific deubiquitinase BRCC36 K11864 BRCC3; BRCA1/BRCA2-containing complex subunit 3 [EC:3.4.19.-]
D BRCA1-B complex
E 105336236 Fanconi anemia group J protein homolog isoform X1 K15362 BRIP1; fanconi anemia group J protein [EC:5.6.2.3]
E 105336157 DNA topoisomerase 2-binding protein 1-A K10728 TOPBP1; topoisomerase (DNA) II binding protein 1
D BRCA1-C complex
E 117684366 double-strand break repair protein MRE11-like K10865 MRE11; double-strand break repair protein MRE11
E 105348988 LOW QUALITY PROTEIN: double-strand break repair protein MRE11 K10865 MRE11; double-strand break repair protein MRE11
E 105348735 DNA repair protein RAD50 isoform X1 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
E 105327116 nibrin isoform X2 K10867 NBN; nibrin
D BRCA complex
E 105327701 breast cancer type 2 susceptibility protein homolog isoform X1 K08775 BRCA2; breast cancer 2 susceptibility protein
E 105332417 DNA repair protein RAD51 homolog 1 K04482 RAD51; DNA repair protein RAD51
D RecA family proteins
E 105332417 DNA repair protein RAD51 homolog 1 K04482 RAD51; DNA repair protein RAD51
E 105335935 DNA repair protein RAD51 homolog 3-like K10870 RAD51L2; RAD51-like protein 2
E 105344249 DNA repair protein RAD51 homolog 4 isoform X3 K10871 RAD51L3; RAD51-like protein 3
E 105345074 DNA repair protein XRCC2 K10879 XRCC2; DNA-repair protein XRCC2
E 105333345 DNA repair protein XRCC3 K10880 XRCC3; DNA-repair protein XRCC3
D Rad52 family proteins
E 105329935 DNA repair and recombination protein RAD52 isoform X4 K10873 RAD52; DNA repair and recombination protein RAD52
E 105325923 uncharacterized protein LOC105325923 K10874 RDM1; RAD52 motif-containing protein 1
D Rad54 family proteins
E 105342477 DNA repair and recombination protein RAD54-like K10875 RAD54L; DNA repair and recombination protein RAD54 and RAD54-like protein [EC:5.6.2.-]
E 105342815 helicase ARIP4 isoform X1 K10876 RAD54L2; RAD54-like protein 2 [EC:5.6.2.-]
E 117682330 LOW QUALITY PROTEIN: helicase ARIP4-like K10876 RAD54L2; RAD54-like protein 2 [EC:5.6.2.-]
E 105338801 DNA repair and recombination protein RAD54B-like isoform X1 K10877 RAD54B; DNA repair and recombination protein RAD54B [EC:5.6.2.-]
D RecQ family DNA helicases
E 105342443 ATP-dependent DNA helicase Q1-like K10899 RECQL; ATP-dependent DNA helicase Q1 [EC:5.6.2.4]
E 105342911 Werner syndrome ATP-dependent helicase homolog isoform X1 K10900 WRN; werner syndrome ATP-dependent helicase [EC:5.6.2.4]
E 105332947 Bloom syndrome protein homolog K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 105346897 ATP-dependent DNA helicase Q-like 3 K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 105327842 ATP-dependent DNA helicase Q4 K10730 RECQL4; ATP-dependent DNA helicase Q4 [EC:5.6.2.4]
E 117680720 ATP-dependent DNA helicase Q4-like K10730 RECQL4; ATP-dependent DNA helicase Q4 [EC:5.6.2.4]
E 105335240 ATP-dependent DNA helicase Q5 K10902 RECQL5; ATP-dependent DNA helicase Q5 [EC:5.6.2.4]
E 117681425 ATP-dependent DNA helicase Q5-like K10902 RECQL5; ATP-dependent DNA helicase Q5 [EC:5.6.2.4]
D Bloom's syndrome complex (BTR)
E 105332947 Bloom syndrome protein homolog K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 105346897 ATP-dependent DNA helicase Q-like 3 K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 105339269 DNA topoisomerase 3-beta-1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 105348065 DNA topoisomerase 3-alpha isoform X1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 105331341 recQ-mediated genome instability protein 1 K10990 RMI1; RecQ-mediated genome instability protein 1
D RPA (replication factor A)
E 105335600 replication protein A 70 kDa DNA-binding subunit isoform X1 K07466 RFA1; replication factor A1
E 105338480 replication protein A 32 kDa subunit-A K10739 RFA2; replication factor A2
E 105342471 replication protein A 14 kDa subunit K10740 RPA3; replication factor A3
D Protein phosphatase 4
E 105331011 serine/threonine-protein phosphatase 4 catalytic subunit K15423 PPP4C; serine/threonine-protein phosphatase 4 catalytic subunit [EC:3.1.3.16]
E 105331825 serine/threonine-protein phosphatase 4 regulatory subunit 1 isoform X1 K15424 PPP4R1; serine/threonine-protein phosphatase 4 regulatory subunit 1
E 105344568 serine/threonine-protein phosphatase 4 regulatory subunit 2-A isoform X1 K15425 PPP4R2; serine/threonine-protein phosphatase 4 regulatory subunit 2
E 105321519 serine/threonine-protein phosphatase 4 regulatory subunit 3A K17491 SMEK; protein phosphatase 4 regulatory subunit 3
E 105328472 serine/threonine-protein phosphatase 4 regulatory subunit 4 isoform X1 K15426 PPP4R4; serine/threonine-protein phosphatase 4 regulatory subunit 4
D AP-5 complex
E 105329256 AP-5 complex subunit beta-1 isoform X1 K19022 AP5B1; AP-5 complex subunit beta-1
E 105341770 AP-5 complex subunit mu-1 K19023 AP5M1; AP-5 complex subunit mu-1
E 105336383 AP-5 complex subunit sigma-1 K19024 AP5S1; AP-5 complex subunit sigma-1
E 105335966 AP-5 complex subunit zeta-1 K19025 AP5Z1; AP-5 complex subunit zeta-1
D SMC5-SMC6 complex
E 105334607 structural maintenance of chromosomes protein 5 K22803 SMC5; structural maintenance of chromosomes protein 5
E 105321610 structural maintenance of chromosomes protein 6 isoform X1 K22804 SMC6; structural maintenance of chromosomes protein 6
E 105322383 non-structural maintenance of chromosomes element 1 homolog isoform X2 K22817 NSMCE1; non-structural maintenance of chromosomes element 1 [EC:2.3.2.27]
E 105343777 E3 SUMO-protein ligase NSE2 K22756 NSMCE2; E3 SUMO-protein ligase NSE2 [EC:2.3.2.-]
E 105328542 non-structural maintenance of chromosomes element 3 homolog K22823 NSMCE3; non-structural maintenance of chromosomes element 3
E 105337248 EP300-interacting inhibitor of differentiation 3 K22825 NSMCE4; non-structural maintenance of chromosomes element 4
E 105345470 SMC5-SMC6 complex localization factor protein 1 K26126 SLF1; SMC5-SMC6 complex localization factor protein 1
E 105336331 SMC5-SMC6 complex localization factor protein 2 isoform X1 K26127 SLF2; SMC5-SMC6 complex localization factor protein 2
D Other HR factors
E 105341158 crossover junction endonuclease EME1 isoform X1 K10882 EME1; crossover junction endonuclease EME1 [EC:3.1.22.-]
E 109619435 crossover junction endonuclease EME1-like K10882 EME1; crossover junction endonuclease EME1 [EC:3.1.22.-]
E 105318969 exonuclease 3'-5' domain-containing protein 2-like K20777 EXD2; exonuclease 3'-5' domain-containing protein 2 [EC:3.1.11.1]
E 105321149 crossover junction endonuclease MUS81 isoform X1 K08991 MUS81; crossover junction endonuclease MUS81 [EC:3.1.22.-]
E 105322792 26S proteasome complex subunit SEM1-like K10881 SHFM1; 26 proteasome complex subunit DSS1
E 117683313 26S proteasome complex subunit SEM1-like K10881 SHFM1; 26 proteasome complex subunit DSS1
E 105333943 DNA repair protein SWI5 homolog K10991 SWI5; DNA repair protein Swi5/Sae3
E 117681224 DNA repair protein SWI5 homolog K10991 SWI5; DNA repair protein Swi5/Sae3
E 105332249 swi5-dependent recombination DNA repair protein 1 homolog isoform X1 K10992 SFR1; Swi5-dependent recombination DNA repair protein 1
E 105342587 structure-specific endonuclease subunit slx1 K15078 SLX1; structure-specific endonuclease subunit SLX1 [EC:3.6.1.-]
E 105324697 structure-specific endonuclease subunit SLX4-like K10484 BTBD12; structure-specific endonuclease subunit SLX4 (BTB/POZ domain-containing protein 12)
E 105331841 flap endonuclease GEN homolog 1 K15338 GEN1; holliday junction resolvase GEN1/YEN1 [EC:3.1.-.-]
E 105333504 flap endonuclease GEN homolog 1 isoform X1 K15338 GEN1; holliday junction resolvase GEN1/YEN1 [EC:3.1.-.-]
E 105333084 spatacsin K19026 SPG11; spatacsin
E 105319618 zinc finger FYVE domain-containing protein 26 isoform X2 K19027 ZFYVE26; zinc finger FYVE domain-containing protein 26
E 105319724 RAD51-associated protein 1 K20778 RAD51AP1; RAD51-associated protein 1
E 105324296 mortality factor 4-like protein 1 isoform X1 K11339 MORF4L1; mortality factor 4-like protein 1
E 105321268 deoxynucleoside triphosphate triphosphohydrolase SAMHD1-like isoform X1 K22544 SAMHD1; deoxynucleoside triphosphate triphosphohydrolase SAMHD1 [EC:3.1.5.-]
E 117692317 deoxynucleoside triphosphate triphosphohydrolase SAMHD1-like isoform X1 K22544 SAMHD1; deoxynucleoside triphosphate triphosphohydrolase SAMHD1 [EC:3.1.5.-]
E 105326774 deoxynucleoside triphosphate triphosphohydrolase SAMHD1 isoform X1 K22544 SAMHD1; deoxynucleoside triphosphate triphosphohydrolase SAMHD1 [EC:3.1.5.-]
E 105340534 deoxynucleoside triphosphate triphosphohydrolase SAMHD1 isoform X1 K22544 SAMHD1; deoxynucleoside triphosphate triphosphohydrolase SAMHD1 [EC:3.1.5.-]
E 117685389 deoxynucleoside triphosphate triphosphohydrolase SAMHD1-like isoform X1 K22544 SAMHD1; deoxynucleoside triphosphate triphosphohydrolase SAMHD1 [EC:3.1.5.-]
E 117686441 deoxynucleoside triphosphate triphosphohydrolase SAMHD1-like K22544 SAMHD1; deoxynucleoside triphosphate triphosphohydrolase SAMHD1 [EC:3.1.5.-]
E 105321436 deoxynucleoside triphosphate triphosphohydrolase SAMHD1 K22544 SAMHD1; deoxynucleoside triphosphate triphosphohydrolase SAMHD1 [EC:3.1.5.-]
E 105317615 deoxynucleoside triphosphate triphosphohydrolase SAMHD1 isoform X1 K22544 SAMHD1; deoxynucleoside triphosphate triphosphohydrolase SAMHD1 [EC:3.1.5.-]
E 105325331 deoxynucleoside triphosphate triphosphohydrolase SAMHD1 isoform X1 K22544 SAMHD1; deoxynucleoside triphosphate triphosphohydrolase SAMHD1 [EC:3.1.5.-]
E 117687819 deoxynucleoside triphosphate triphosphohydrolase SAMHD1-like K22544 SAMHD1; deoxynucleoside triphosphate triphosphohydrolase SAMHD1 [EC:3.1.5.-]
E 117690630 deoxynucleoside triphosphate triphosphohydrolase SAMHD1-like K22544 SAMHD1; deoxynucleoside triphosphate triphosphohydrolase SAMHD1 [EC:3.1.5.-]
E 105342055 fidgetin-like protein 1 isoform X1 K22766 FIGNL1; fidgetin-like protein 1 [EC:5.6.2.-]
E 105321090 DNA repair-scaffolding protein isoform X1 K22806 SPIDR; DNA repair-scaffolding protein
E 105339180 BRCA1-associated ATM activator 1 K23112 BRAT1; BRCA1-associated ATM activator 1
E 105331875 cilia- and flagella-associated protein 410 K23456 CFAP410; cilla- and flagella-associated protein
E 105342917 hepatoma-derived growth factor-related protein 2 isoform X1 K25065 HDGFL2; hepatoma-derived growth factor-related protein 2
E 105332651 zinc finger SWIM domain-containing protein 7 K25770 ZSWIM7; zinc finger SWIM domain-containing protein 7
E 105344197 uncharacterized protein LOC105344197 K25771 SWSAP1; ATPase SWSAP1
E 105331296 BRCA2-interacting transcriptional repressor EMSY isoform X1 K25790 EMSY; BRCA2-interacting transcriptional repressor EMSY
E 105348302 heat shock factor 2-binding protein isoform X1 K25791 HSF2BP; heat shock factor 2-binding protein
E 105321867 protein MMS22-like K26125 MMS22L; protein MMS22-like
E 105341624 tonsoku-like protein K09257 NFKBIL2; NF-kappa-B inhibitor-like protein 2
E 105329459 PCNA-interacting partner K27412 PARPBP; PCNA-interacting partner
C NHEJ (non-homologous end-joining)
D DNA-PK complex
E 105339795 X-ray repair cross-complementing protein 5 isoform X1 K10884 XRCC6; ATP-dependent DNA helicase 2 subunit 1
E 105326426 X-ray repair cross-complementing protein 5 K10885 XRCC5; ATP-dependent DNA helicase 2 subunit 2
E 105317076 DNA-dependent protein kinase catalytic subunit K06642 PRKDC; DNA-dependent protein kinase catalytic subunit [EC:2.7.11.1]
D MRX complex
E 117684366 double-strand break repair protein MRE11-like K10865 MRE11; double-strand break repair protein MRE11
E 105348988 LOW QUALITY PROTEIN: double-strand break repair protein MRE11 K10865 MRE11; double-strand break repair protein MRE11
E 105348735 DNA repair protein RAD50 isoform X1 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
D DNA Ligase 4 complex
E 105336061 DNA ligase 4 K10777 LIG4; DNA ligase 4 [EC:6.5.1.1]
E 105329904 non-homologous end-joining factor 1 K10980 NHEJ1; non-homologous end-joining factor 1
D X-family DNA polymerases
E 105344137 DNA polymerase lambda isoform X1 K03512 POLL; DNA polymerase lambda [EC:2.7.7.7 4.2.99.-]
E 105326976 DNA-directed DNA/RNA polymerase mu K03513 POLM; DNA polymerase mu [EC:2.7.7.7]
E 105341699 DNA polymerase beta K02330 POLB; DNA polymerase beta [EC:2.7.7.7 4.2.99.-]
D Other NHEJ factors
E 105322078 aprataxin isoform X3 K10863 APTX; aprataxin [EC:3.6.1.70 3.6.1.71 3.6.1.72]
E 105336765 aprataxin and PNK-like factor isoform X1 K13295 APLF; aprataxin and PNK-like factor [EC:3.1.-.-]
E 105319975 protein artemis isoform X1 K10887 DCLRE1C; DNA cross-link repair 1C protein [EC:3.1.-.-]
E 105325443 tyrosyl-DNA phosphodiesterase 2 K19619 TDP2; tyrosyl-DNA phosphodiesterase 2 [EC:3.1.4.-]
E 117690288 tyrosyl-DNA phosphodiesterase 2-like K19619 TDP2; tyrosyl-DNA phosphodiesterase 2 [EC:3.1.4.-]
E 109618389 tyrosyl-DNA phosphodiesterase 2-like K19619 TDP2; tyrosyl-DNA phosphodiesterase 2 [EC:3.1.4.-]
E 105340669 structural maintenance of chromosomes flexible hinge domain-containing protein 1 K23113 SMCHD1; structural maintenance of chromosomes flexible hinge domain-containing protein 1
E 105317804 protein PAXX K25772 PAXX; protein PAXX
E 105339238 jmjC domain-containing protein 8 K25792 JMJD8; jumonji domain-containing protein 8
C FA (Fanconi anemia) pathway
D FA core complex
E 105344574 uncharacterized protein LOC105344574 K10888 FANCA; fanconi anemia group A protein
E 105324850 uncharacterized protein LOC105324850 K10889 FANCB; fanconi anemia group B protein
E 105318647 uncharacterized protein LOC105318647 isoform X1 K10892 FANCE; fanconi anemia group E protein
E 105336256 uncharacterized protein LOC105336256 isoform X1 K10893 FANCF; fanconi anemia group F protein
E 105347836 uncharacterized protein LOC105347836 isoform X1 K10894 FANCG; fanconi anemia group G protein
E 105318110 E3 ubiquitin-protein ligase FANCL K10606 FANCL; E3 ubiquitin-protein ligase FANCL [EC:2.3.2.27]
E 105335431 Fanconi anemia group M protein K10896 FANCM; fanconi anemia group M protein
E 105325569 Fanconi anemia core complex-associated protein 24 K10898 FAAP24; fanconi anemia-associated protein
D FA core complex binding factors
E 105321711 protein hairy K06054 HES1; hairy and enhancer of split 1
E 105321712 protein hairy isoform X1 K06054 HES1; hairy and enhancer of split 1
E 105327843 uncharacterized protein LOC105327843 K06054 HES1; hairy and enhancer of split 1
E 105327857 uncharacterized protein LOC105327857 K06054 HES1; hairy and enhancer of split 1
E 105333242 enhancer of split m7 protein-like K06054 HES1; hairy and enhancer of split 1
E 105339144 transcription factor HES-2-like K06054 HES1; hairy and enhancer of split 1
E 105348553 transcription factor HES-2 K06054 HES1; hairy and enhancer of split 1
E 105348555 transcription factor HES-4-A K06054 HES1; hairy and enhancer of split 1
E 105348556 transcription factor HES-1 K06054 HES1; hairy and enhancer of split 1
E 117680718 uncharacterized protein LOC117680718 K06054 HES1; hairy and enhancer of split 1
E 117680719 uncharacterized protein LOC117680719 K06054 HES1; hairy and enhancer of split 1
E 105329022 centromere protein S K11511 APITD1; centromere protein S
E 105320682 centromere protein X-like K15360 STRA13; centromere protein X
E 117681002 ubiquitin-conjugating enzyme E2 T-like K13960 UBE2T; ubiquitin-conjugating enzyme E2 T [EC:2.3.2.23]
E 105325483 ubiquitin-conjugating enzyme E2 T isoform X1 K13960 UBE2T; ubiquitin-conjugating enzyme E2 T [EC:2.3.2.23]
D Bloom's syndrome complex (BTR)
E 105332947 Bloom syndrome protein homolog K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 105346897 ATP-dependent DNA helicase Q-like 3 K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 105339269 DNA topoisomerase 3-beta-1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 105348065 DNA topoisomerase 3-alpha isoform X1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 105331341 recQ-mediated genome instability protein 1 K10990 RMI1; RecQ-mediated genome instability protein 1
D FANCD2-I complex
E 105337649 Fanconi anemia group D2 protein K10891 FANCD2; fanconi anemia group D2 protein
E 105336002 Fanconi anemia group I protein K10895 FANCI; fanconi anemia group I protein
D Downstream FA components
E 105327701 breast cancer type 2 susceptibility protein homolog isoform X1 K08775 BRCA2; breast cancer 2 susceptibility protein
E 105336236 Fanconi anemia group J protein homolog isoform X1 K15362 BRIP1; fanconi anemia group J protein [EC:5.6.2.3]
D Other FA pathway factors
E 105329336 fanconi-associated nuclease 1 K15363 FAN1; fanconi-associated nuclease 1 [EC:3.1.21.- 3.1.4.1]
E 105332417 DNA repair protein RAD51 homolog 1 K04482 RAD51; DNA repair protein RAD51
E 105335935 DNA repair protein RAD51 homolog 3-like K10870 RAD51L2; RAD51-like protein 2
E 105326836 telomere length regulation protein TEL2 homolog isoform X1 K11137 TELO2; telomere length regulation protein
E 105333421 ubiquitin carboxyl-terminal hydrolase 1 isoform X1 K11832 USP1; ubiquitin carboxyl-terminal hydrolase 1 [EC:3.4.19.12]
E 105325941 WD repeat-containing protein 48 K15361 WDR48; WD repeat-containing protein 48
E 105345849 WD repeat-containing protein 48-like isoform X1 K15361 WDR48; WD repeat-containing protein 48
C Other DSBR factors
D Protein phosphatase 6
E 105332168 serine/threonine-protein phosphatase 6 catalytic subunit K15498 PPP6C; serine/threonine-protein phosphatase 6 catalytic subunit [EC:3.1.3.16]
E 105348289 serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X2 K15501 PPP6R3; serine/threonine-protein phosphatase 6 regulatory subunit 3
E 105344149 serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A isoform X1 K15502 ANKRD28; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A
D Ubiquitin ligases
E 105347930 E3 ubiquitin-protein ligase RNF8 K10667 RNF8; E3 ubiquitin-protein ligase RNF8 [EC:2.3.2.27]
E 105330677 E3 ubiquitin-protein ligase RNF168 K20779 RNF168; E3 ubiquitin-protein ligase RNF168 [EC:2.3.2.31]
E 105319253 E3 ubiquitin-protein ligase HERC2 isoform X1 K10595 HERC2; E3 ubiquitin-protein ligase HERC2 [EC:2.3.2.26]
D Others
E 105338647 telomerase Cajal body protein 1 K23314 WRAP53; telomerase Cajal body protein 1
E 105342864 histone-lysine N-methyltransferase NSD2 isoform X2 K24688 ZCWPW1; zinc finger CW-type PWWP domain protein 1
E 105336632 WD repeat-containing protein 70 K24752 WDR70; WD repeat-containing protein 70
E 105319435 WD repeat-containing protein 76 K24755 WDR76; WD repeat-containing protein 76
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
D 117688840 LOW QUALITY PROTEIN: DNA polymerase eta-like K03509 POLH; DNA polymerase eta [EC:2.7.7.7]
D 105334737 DNA polymerase iota isoform X1 K03510 POLI; DNA polymerase iota [EC:2.7.7.7]
D 105317179 DNA polymerase kappa K03511 POLK; DNA polymerase kappa [EC:2.7.7.7]
D 117689046 DNA polymerase kappa-like K03511 POLK; DNA polymerase kappa [EC:2.7.7.7]
D 105331253 DNA repair protein REV1 K03515 REV1; DNA repair protein REV1 [EC:2.7.7.-]
C B-family DNA polymerases
D 105324789 DNA polymerase zeta catalytic subunit isoform X1 K02350 REV3L; DNA polymerase zeta [EC:2.7.7.7]
D 105334281 uncharacterized protein LOC105334281 isoform X1 K02350 REV3L; DNA polymerase zeta [EC:2.7.7.7]
C A-family DNA polymerase
D 105348202 DNA polymerase nu isoform X2 K16618 POLN; DNA polymerase nu [EC:2.7.7.7]
C Rad6 epistasis group
D 105340382 ubiquitin-conjugating enzyme E2 A isoform X1 K10573 UBE2A; ubiquitin-conjugating enzyme E2 A [EC:2.3.2.23]
D 105336737 uncharacterized protein LOC105336737 isoform X1 K10627 RAD18; E3 ubiquitin-protein ligase RAD18 [EC:2.3.2.27]
D 105349024 helicase-like transcription factor isoform X1 K15711 SMARCA3; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A3 [EC:5.6.2. 2.3.2.27]
D 105346610 ubiquitin-conjugating enzyme E2 variant 1 K10704 UBE2V; ubiquitin-conjugating enzyme E2 variant
D 105335216 ubiquitin-conjugating enzyme E2 N K10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23]
C Other TLS factors
D 105341104 proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
D 105329459 PCNA-interacting partner K27412 PARPBP; PCNA-interacting partner
D 105341756 sprT-like domain-containing protein Spartan K24051 SPRTN; SprT-like domain-contaning protein Spartan
D 117680434 sprT-like domain-containing protein Spartan K24051 SPRTN; SprT-like domain-contaning protein Spartan
D 105329863 acidic repeat-containing protein K26957 GCNA; germ cell nuclear acidic protein
B Check point factors
C Rad9-Hus1-Rad1 complex
D 105318649 cell cycle checkpoint control protein RAD9A isoform X1 K10994 RAD9A; cell cycle checkpoint control protein RAD9A [EC:3.1.11.2]
D 105322706 checkpoint protein HUS1 K10903 HUS1; HUS1 checkpoint protein
D 105347000 cell cycle checkpoint protein RAD1-like K02830 HRAD1; cell cycle checkpoint protein [EC:3.1.11.2]
C HRAD17(Rad24)-RFC complex
D 105320658 cell cycle checkpoint protein RAD17-like isoform X1 K06662 HRAD17; cell cycle checkpoint protein
D 105317478 replication factor C subunit 2 K10755 RFC2_4; replication factor C subunit 2/4
D 105332688 replication factor C subunit 4 K10755 RFC2_4; replication factor C subunit 2/4
D 105332020 replication factor C subunit 5 K10756 RFC3_5; replication factor C subunit 3/5
D 105339014 replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
C Rad17-Mec3-Ddc1 complex
D 105347000 cell cycle checkpoint protein RAD1-like K02830 HRAD1; cell cycle checkpoint protein [EC:3.1.11.2]
C FPC (fork protection complex)
D 105329978 uncharacterized protein LOC105329978 K10997 TIMELESS; replication fork protection complex subunit TIMELESS/Tof1/Swi1
D 105338258 protein timeless homolog K10997 TIMELESS; replication fork protection complex subunit TIMELESS/Tof1/Swi1
D 105345143 uncharacterized protein LOC105345143 isoform X1 K10998 TIPIN; replication fork protection complex subunit TIPIN/Csm3/Swi3
D 105320110 claspin isoform X2 K25773 CLSPN; claspin
C Triple T complex
D 105326836 telomere length regulation protein TEL2 homolog isoform X1 K11137 TELO2; telomere length regulation protein
D 105334475 TELO2-interacting protein 1 homolog K20403 TTI1; TELO2-interacting protein 1
C BAG6-UBL4A-GET4 complex
D 105343421 large proline-rich protein BAG6 isoform X1 K23390 BAG6; large proline-rich protein BAG6
D 117682151 ubiquitin-like protein 4A isoform X1 K23388 UBL4; ubiquitin-like protein 4
D 105341015 Golgi to ER traffic protein 4 homolog K23387 GET4; golgi to ER traffic protein 4
C Other check point factors
D 105319069 serine/threonine-protein kinase ATR isoform X1 K06640 ATR; serine/threonine-protein kinase ATR [EC:2.7.11.1]
D 105322373 ATR-interacting protein isoform X2 K10905 ATRIP; ATR interacting protein
D 105317516 serine-protein kinase ATM isoform X1 K04728 ATM; serine-protein kinase ATM [EC:2.7.11.1]
D 105344353 serine/threonine-protein kinase Chk1 K02216 CHEK1; serine/threonine-protein kinase CHEK1 [EC:2.7.11.1]
D 105318723 serine/threonine-protein kinase Chk2 K06641 CHEK2; serine/threonine-protein kinase CHEK2 [EC:2.7.11.1]
D 105344441 M-phase inducer phosphatase 1 K06645 CDC25A; M-phase inducer phosphatase 1 [EC:3.1.3.48]
D 105325137 M-phase inducer phosphatase K05866 CDC25B; M-phase inducer phosphatase 2 [EC:3.1.3.48]
D 105337712 M-phase inducer phosphatase isoform X1 K05866 CDC25B; M-phase inducer phosphatase 2 [EC:3.1.3.48]
D 105344432 M-phase inducer phosphatase 1 K05866 CDC25B; M-phase inducer phosphatase 2 [EC:3.1.3.48]
D 105348591 M-phase inducer phosphatase K05866 CDC25B; M-phase inducer phosphatase 2 [EC:3.1.3.48]
D 105344440 M-phase inducer phosphatase K05866 CDC25B; M-phase inducer phosphatase 2 [EC:3.1.3.48]
D 105344598 M-phase inducer phosphatase K05866 CDC25B; M-phase inducer phosphatase 2 [EC:3.1.3.48]
D 105337335 14-3-3-like protein 2 isoform X1 K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
D 105325342 14-3-3 protein beta/alpha-B-like K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
D 105325344 14-3-3 protein beta/alpha-A K16198 YWHAG_H; 14-3-3 protein gamma/eta
D 105321521 14-3-3 protein epsilon K06630 YWHAE; 14-3-3 protein epsilon
D 105334383 neuron navigator 2 isoform X1 K19483 NAV2; neuron navigator 2 [EC:5.6.2.4]
D 105332881 wee1-like protein kinase 1-A K06632 WEE1; wee1-like protein kinase [EC:2.7.11.1]
D 105333254 period circadian protein homolog 1 isoform X1 K02633 PER2; period circadian protein 2
D 105329754 mediator of DNA damage checkpoint protein 1 K20780 MDC1; mediator of DNA damage checkpoint protein 1
D 105319795 plastin-3 isoform X1 K17336 PLS3; plastin-3
D 105322077 serine/threonine-protein kinase Nek2 isoform X1 K08857 NEK1_4_5; serine/threonine-protein kinase Nek1/4/5 [EC:2.7.11.1]
D 105336215 serine/threonine-protein kinase Nek6 isoform X2 K08857 NEK1_4_5; serine/threonine-protein kinase Nek1/4/5 [EC:2.7.11.1]
D 105336212 serine/threonine-protein kinase Nek4 K08857 NEK1_4_5; serine/threonine-protein kinase Nek1/4/5 [EC:2.7.11.1]
D 105330383 serine/threonine-protein kinase Nek4 isoform X1 K08857 NEK1_4_5; serine/threonine-protein kinase Nek1/4/5 [EC:2.7.11.1]
D 105335157 serine/threonine-protein kinase Nek1 isoform X1 K08857 NEK1_4_5; serine/threonine-protein kinase Nek1/4/5 [EC:2.7.11.1]
D 105333057 serine/threonine-protein kinase Nek10-like isoform X1 K20879 NEK10; serine/threonine-protein kinase Nek10 [EC:2.7.11.1]
D 105334704 serine/threonine-protein kinase Nek11 isoform X1 K20880 NEK11; serine/threonine-protein kinase Nek11 [EC:2.7.11.1]
D 105343941 protein downstream neighbor of son homolog K22422 DONSON; protein downstream neighbor of Son
D 105328889 KN motif and ankyrin repeat domain-containing protein 2 isoform X1 K22808 KANK; KN motif and ankyrin repeat domain-containing protein
D 105331606 vacuolar protein sorting-associated protein 4B-like isoform X2 K12196 VPS4; vacuolar protein-sorting-associated protein 4
D 105325544 vacuolar protein sorting-associated protein 4B-like isoform X1 K12196 VPS4; vacuolar protein-sorting-associated protein 4
D 105344075 vacuolar protein sorting-associated protein 4B-like isoform X1 K12196 VPS4; vacuolar protein-sorting-associated protein 4
D 105331612 vacuolar protein sorting-associated protein 4B K12196 VPS4; vacuolar protein-sorting-associated protein 4
D 105319533 vacuolar protein sorting-associated protein 4 isoform X1 K12196 VPS4; vacuolar protein-sorting-associated protein 4
D 105341252 abscission/NoCut checkpoint regulator-like K24778 ZFYVE19; abscission/NoCut checkpoint regulator
D 105345919 replication stress response regulator SDE2 K25059 SDE2; replication stress response regulator SDE2
B Other factors with a suspected DNA repair function
C DNA polymerases
D 105329994 DNA polymerase theta K02349 POLQ; DNA polymerase theta [EC:2.7.7.7]
D 105327853 myb-binding protein 1A-like protein isoform X1 K02331 POL5; DNA polymerase phi [EC:2.7.7.7]
D 105339045 DNA-directed primase/polymerase protein K22761 PRIMPOL; DNA-directed primase/polymerase protein [EC:2.7.7.102 2.7.7.7]
C Nucleases
D 105332772 DNA cross-link repair 1A protein isoform X1 K15340 DCLRE1A; DNA cross-link repair 1A protein
D 105323039 5' exonuclease Apollo K15341 DCLRE1B; DNA cross-link repair 1B protein [EC:3.1.-.-]
D 105343710 exonuclease V K17815 EXO5; exonuclease V [EC:3.1.-.-]
D 105338745 endonuclease V-like K21813 ENDOV; endonuclease V [EC:3.1.26.-]
D 105335669 DNA annealing helicase and endonuclease ZRANB3 isoform X1 K25861 ZRANB3; DNA annealing helicase and endonuclease ZRANB3 [EC:5.6.2.- 3.1.-.-]
D 105341309 ankyrin repeat and LEM domain-containing protein 1 isoform X1 K21411 ANKLE1; ankyrin repeat and LEM domain-containing protein 1
C Helicases
D 105326570 helicase POLQ-like isoform X1 K19178 HELQ; POLQ-like helicase [EC:5.6.2.4]
D 105328834 helicase POLQ-like isoform X1 K19178 HELQ; POLQ-like helicase [EC:5.6.2.4]
D 105345402 DNA excision repair protein ERCC-6-like 2 isoform X1 K20098 ERCC6L2; DNA excision repair protein ERCC-6-like 2 [EC:5.6.2.-]
C PSO4 complex
D 105343163 pre-mRNA-processing factor 19 K10599 PRPF19; pre-mRNA-processing factor 19 [EC:2.3.2.27]
D 117689257 uncharacterized protein LOC117689257 K10599 PRPF19; pre-mRNA-processing factor 19 [EC:2.3.2.27]
D 105334527 cell division cycle 5-like protein K12860 CDC5L; pre-mRNA-splicing factor CDC5/CEF1
D 105321821 pre-mRNA-splicing factor SPF27 K12861 BCAS2; pre-mRNA-splicing factor SPF27
D 105334692 pleiotropic regulator 1 K12862 PLRG1; pleiotropic regulator 1
C Modulation of nucleotide pools
D 105317371 7,8-dihydro-8-oxoguanine triphosphatase K17816 NUDT1; 8-oxo-dGTP diphosphatase / 2-hydroxy-dATP diphosphatase [EC:3.6.1.55 3.6.1.56]
D 105337872 8-oxo-dGDP phosphatase NUDT18 K17817 NUDT18; 8-oxo-dGDP phosphatase [EC:3.6.1.58]
D 105343526 deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 105343546 deoxyuridine 5'-triphosphate nucleotidohydrolase K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 117683008 deoxyuridine 5'-triphosphate nucleotidohydrolase-like K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 105348744 ribonucleoside-diphosphate reductase large subunit K10807 RRM1; ribonucleoside-diphosphate reductase subunit M1 [EC:1.17.4.1]
D 105336299 ribonucleoside-diphosphate reductase small chain K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]
#
AProkaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D 105328756 methylated-DNA--protein-cysteine methyltransferase K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
D 105325072 deoxyribodipyrimidine photo-lyase K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]
C BER (base exicision repair)
D DNA glycosylases
E 105319857 uracil-DNA glycosylase 2 K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E 105346809 uracil-DNA glycosylase isoform X1 K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E 105335077 putative 3-methyladenine DNA glycosylase isoform X1 K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]
E 105329457 adenine DNA glycosylase K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
D AP endonucleases
D RecJ
D DNA ligase
D DNA polymerase I
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase complex (RNAP)
E TRCF (transcription-repair coupling factor)
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
D Molecular matchmaker
D Strand discrimination factor
D DNA exonucleases
D DNA polymerase III holoenzyme
D DNA ligase
D Other MMR factors
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D RecBC pathway proteins
D RecFOR pathway proteins
D AddAB pathway proteins
D Other HR factor
D Archaeal homologous recombinant proteins
C NHEJ (non-homologous end-joining)
D Two-component NHEJ DNA repair complex
D SHIIR (short-homology-independent illegitimate recombination)
E Facilitator
E Supressor
D SHDIR (short-homology-dependent illegitimate recombination)
E RecET pathway
E Facilitator
E Supressor
F 117693110 ATP-dependent DNA helicase Q-like 3 K03654 recQ; ATP-dependent DNA helicase RecQ [EC:5.6.2.4]
F 117685686 ATP-dependent DNA helicase RecQ-like K03654 recQ; ATP-dependent DNA helicase RecQ [EC:5.6.2.4]
F 117685996 Werner syndrome ATP-dependent helicase homolog K03654 recQ; ATP-dependent DNA helicase RecQ [EC:5.6.2.4]
F 105329363 ATP-dependent DNA helicase Q-like SIM K03654 recQ; ATP-dependent DNA helicase RecQ [EC:5.6.2.4]
F 105348008 probable ATP-dependent DNA helicase RecS K03654 recQ; ATP-dependent DNA helicase RecQ [EC:5.6.2.4]
F 105328115 ATP-dependent DNA helicase RecQ isoform X1 K03654 recQ; ATP-dependent DNA helicase RecQ [EC:5.6.2.4]
F 109617800 ATP-dependent DNA helicase RecQ K03654 recQ; ATP-dependent DNA helicase RecQ [EC:5.6.2.4]
F 109619424 probable ATP-dependent DNA helicase RecS K03654 recQ; ATP-dependent DNA helicase RecQ [EC:5.6.2.4]
F 117688168 ATP-dependent DNA helicase RecQ-like isoform X1 K03654 recQ; ATP-dependent DNA helicase RecQ [EC:5.6.2.4]
F 109621022 ATP-dependent DNA helicase Q-like 3 K03654 recQ; ATP-dependent DNA helicase RecQ [EC:5.6.2.4]
F 117688812 ATP-dependent DNA helicase Q-like 3 K03654 recQ; ATP-dependent DNA helicase RecQ [EC:5.6.2.4]
F 105324005 Bloom syndrome protein homolog K03654 recQ; ATP-dependent DNA helicase RecQ [EC:5.6.2.4]
F 109617963 ATP-dependent DNA helicase Q-like SIM K03654 recQ; ATP-dependent DNA helicase RecQ [EC:5.6.2.4]
F 105334541 ATP-dependent DNA helicase Q-like SIM K03654 recQ; ATP-dependent DNA helicase RecQ [EC:5.6.2.4]
F 117689866 ATP-dependent DNA helicase Q-like 3 K03654 recQ; ATP-dependent DNA helicase RecQ [EC:5.6.2.4]
F 117690569 ATP-dependent DNA helicase Q-like SIM isoform X1 K03654 recQ; ATP-dependent DNA helicase RecQ [EC:5.6.2.4]
F 117690753 Werner syndrome ATP-dependent helicase-like K03654 recQ; ATP-dependent DNA helicase RecQ [EC:5.6.2.4]
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
C Other SOS response factors
B Other factors with a suspected DNA repair function
C DNA polymerase
C DNA helicases
C Modulation of nucleotide pools
D 105343526 deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 105343546 deoxyuridine 5'-triphosphate nucleotidohydrolase K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 117683008 deoxyuridine 5'-triphosphate nucleotidohydrolase-like K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
C Others
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: March 29, 2024