+C Two-component system KO #

  Two-Component System - Cupriavidus sp. USMAA2-4

% ! AOmpR family B PhoR-PhoB (phosphate starvation response) C BKK79_17930 phosphate regulon sensor histidine kinase PhoR K07636 phoR; two-component system, OmpR family, phosphate regulon sensor histidine kinase PhoR [EC:2.7.13.3] C BKK79_17925 phosphate regulon transcriptional regulatory protein PhoB K07657 phoB; two-component system, OmpR family, phosphate regulon response regulator PhoB B SenX3-RegX3 (phosphate starvation response) B PhoQ-PhoP (magnesium transport) B EnvZ-OmpR (osmotic stress response) C BKK79_19550 two-component sensor histidine kinase K07638 envZ; two-component system, OmpR family, osmolarity sensor histidine kinase EnvZ [EC:2.7.13.3] C BKK79_00595 two-component sensor histidine kinase K07638 envZ; two-component system, OmpR family, osmolarity sensor histidine kinase EnvZ [EC:2.7.13.3] C BKK79_07390 two-component sensor histidine kinase K07638 envZ; two-component system, OmpR family, osmolarity sensor histidine kinase EnvZ [EC:2.7.13.3] C BKK79_00600 two-component system response regulator OmpR K07659 ompR; two-component system, OmpR family, phosphate regulon response regulator OmpR C BKK79_07395 ompR; two-component system response regulator OmpR K07659 ompR; two-component system, OmpR family, phosphate regulon response regulator OmpR C BKK79_19555 DNA-binding response regulator K07659 ompR; two-component system, OmpR family, phosphate regulon response regulator OmpR B RstB-RstA B CpxA-CpxR (envelope stress response) B CssS-CssR (secretion stress response) B CreC-CreB (phosphate regulation) B BaeS-BaeR (envelope stress response) B BasS-BasR (antimicrobial peptide resistance) B CusS-CusR (copper tolerance) C BKK79_08510 two-component sensor histidine kinase K07644 cusS; two-component system, OmpR family, heavy metal sensor histidine kinase CusS [EC:2.7.13.3] C BKK79_33525 two-component sensor histidine kinase K07644 cusS; two-component system, OmpR family, heavy metal sensor histidine kinase CusS [EC:2.7.13.3] C BKK79_36325 two-component sensor histidine kinase K07644 cusS; two-component system, OmpR family, heavy metal sensor histidine kinase CusS [EC:2.7.13.3] C BKK79_32820 two-component sensor histidine kinase K07644 cusS; two-component system, OmpR family, heavy metal sensor histidine kinase CusS [EC:2.7.13.3] C BKK79_37475 two-component sensor histidine kinase K07644 cusS; two-component system, OmpR family, heavy metal sensor histidine kinase CusS [EC:2.7.13.3] C BKK79_38355 two-component sensor histidine kinase K07644 cusS; two-component system, OmpR family, heavy metal sensor histidine kinase CusS [EC:2.7.13.3] C BKK79_08515 DNA-binding response regulator K07665 cusR; two-component system, OmpR family, copper resistance phosphate regulon response regulator CusR C BKK79_33530 DNA-binding response regulator K07665 cusR; two-component system, OmpR family, copper resistance phosphate regulon response regulator CusR C BKK79_36320 DNA-binding response regulator K07665 cusR; two-component system, OmpR family, copper resistance phosphate regulon response regulator CusR C BKK79_32815 DNA-binding response regulator K07665 cusR; two-component system, OmpR family, copper resistance phosphate regulon response regulator CusR C BKK79_37470 DNA-binding response regulator K07665 cusR; two-component system, OmpR family, copper resistance phosphate regulon response regulator CusR C BKK79_38350 DNA-binding response regulator K07665 cusR; two-component system, OmpR family, copper resistance phosphate regulon response regulator CusR B QseC-QseB (quorum sensing) B KdpD-KdpE (potassium transport) C BKK79_10045 two-component sensor histidine kinase K07646 kdpD; two-component system, OmpR family, sensor histidine kinase KdpD [EC:2.7.13.3] C BKK79_10040 two-component system response regulator KdpE K07667 kdpE; two-component system, OmpR family, KDP operon response regulator KdpE B TorS-TorR (TMAO respiration) B ArcB-ArcA (anoxic redox control) B TctE-TctD (tricarboxylic acid transport) C BKK79_11105 histidine kinase K07649 tctE; two-component system, OmpR family, sensor histidine kinase TctE [EC:2.7.13.3] C BKK79_18145 hypothetical protein K07649 tctE; two-component system, OmpR family, sensor histidine kinase TctE [EC:2.7.13.3] C BKK79_32950 sensor histidine kinase K07649 tctE; two-component system, OmpR family, sensor histidine kinase TctE [EC:2.7.13.3] C BKK79_07420 histidine kinase K07649 tctE; two-component system, OmpR family, sensor histidine kinase TctE [EC:2.7.13.3] C BKK79_11335 histidine kinase K07649 tctE; two-component system, OmpR family, sensor histidine kinase TctE [EC:2.7.13.3] C BKK79_11100 DNA-binding response regulator K07774 tctD; two-component system, OmpR family, response regulator TctD C BKK79_32955 DNA-binding response regulator K07774 tctD; two-component system, OmpR family, response regulator TctD C BKK79_07425 DNA-binding response regulator K07774 tctD; two-component system, OmpR family, response regulator TctD B ResE-ResD (aerobic and anaerobic respiration) B VicK-VicR (cell wall metabolism) B MprB-MprA (maintenance of persistent infection) B MtrB-MtrA (osmotic stress response) B PrrB-PrrA (intracellular multiplication) B TrcS-TrcR B NrsS-NrsR (nickel tolerance) B ManS-ManR (manganese homeostasis) B NblS-NblR (photosynthesis) B SasA-RpaAB (circadian timing mediating) B SaeS-SaeR (staphylococcal virulence regulation) B BceS-BceR (bacitracin transport) B BraS-BraR (bacitracin transport) B GraS-GraR (cationic antimicrobial peptide transport) B YxdK-YxdJ (antimicrobial peptide response) B ChvG-ChvI (acidity sensing) B CiaH-CiaR B ParS-ParR (polymyxin-adaptive resistance) C BKK79_33710 DNA-binding response regulator K18073 parR; two-component system, OmpR family, response regulator ParR B AdeS-AdeR B VanS-VanR (VanB type vancomycin resistance) B VanS-VanR (VanE type vancomycin resistance) B VanS-VanR (actinomycete type vancomycin resistance) B ArlS-ArlR (virulence regulation) B Ihk-Irr (virulence regulation) B PfeS-PfeR (enterobactin-dependent iron acquisition) B NisK-NisR (lantibiotic biosynthesis) B Unclassified C BKK79_25210 two-component sensor histidine kinase K02484 K02484; two-component system, OmpR family, sensor kinase [EC:2.7.13.3] C BKK79_13135 two-component sensor histidine kinase K02484 K02484; two-component system, OmpR family, sensor kinase [EC:2.7.13.3] C BKK79_22170 hypothetical protein K02484 K02484; two-component system, OmpR family, sensor kinase [EC:2.7.13.3] C BKK79_31290 hypothetical protein K02484 K02484; two-component system, OmpR family, sensor kinase [EC:2.7.13.3] C BKK79_23360 two-component sensor histidine kinase K02484 K02484; two-component system, OmpR family, sensor kinase [EC:2.7.13.3] C BKK79_32030 histidine kinase K02484 K02484; two-component system, OmpR family, sensor kinase [EC:2.7.13.3] C BKK79_25215 DNA-binding response regulator K02483 K02483; two-component system, OmpR family, response regulator C BKK79_07625 DNA-binding response regulator K02483 K02483; two-component system, OmpR family, response regulator C BKK79_11635 DNA-binding response regulator K02483 K02483; two-component system, OmpR family, response regulator C BKK79_31790 DNA-binding response regulator K02483 K02483; two-component system, OmpR family, response regulator C BKK79_13140 DNA-binding response regulator K02483 K02483; two-component system, OmpR family, response regulator C BKK79_22165 DNA-binding response regulator K02483 K02483; two-component system, OmpR family, response regulator C BKK79_31285 DNA-binding response regulator K02483 K02483; two-component system, OmpR family, response regulator C BKK79_23355 DNA-binding response regulator K02483 K02483; two-component system, OmpR family, response regulator C BKK79_23430 DNA-binding response regulator K02483 K02483; two-component system, OmpR family, response regulator C BKK79_09785 two-component system response regulator K02483 K02483; two-component system, OmpR family, response regulator C BKK79_11340 DNA-binding response regulator K02483 K02483; two-component system, OmpR family, response regulator C BKK79_02670 DNA-binding response regulator K02483 K02483; two-component system, OmpR family, response regulator # ANarL family B NarX-NarL (nitrate respiration) C BKK79_14705 DNA-binding response regulator K07684 narL; two-component system, NarL family, nitrate/nitrite response regulator NarL C BKK79_25335 hypothetical protein K07684 narL; two-component system, NarL family, nitrate/nitrite response regulator NarL C BKK79_34750 DNA-binding response regulator K07684 narL; two-component system, NarL family, nitrate/nitrite response regulator NarL B NarQ-NarP (nitrate respiration) B UhpB-UhpA (hexose phosphates uptake) B FusK-FusR (virulence regulation) B RcsC-RcsD-RcsB (capsule synthesis) C BKK79_01265 hypothetical protein K07677 rcsC; two-component system, NarL family, capsular synthesis sensor histidine kinase RcsC [EC:2.7.13.3] C BKK79_19190 DNA-binding response regulator K07687 rcsB; two-component system, NarL family, captular synthesis response regulator RcsB C BKK79_23210 DNA-binding response regulator K07687 rcsB; two-component system, NarL family, captular synthesis response regulator RcsB B BarA-UvrY (central carbon metabolism) C BKK79_09790 DNA-binding response regulator K07689 uvrY; two-component system, NarL family, invasion response regulator UvrY B ComP-ComA (competence) B EvgS-EvgA (acid and drug tolerance) C BKK79_01275 hypothetical protein K07679 evgS; two-component system, NarL family, sensor histidine kinase EvgS [EC:2.7.13.3] C BKK79_17680 hypothetical protein K07679 evgS; two-component system, NarL family, sensor histidine kinase EvgS [EC:2.7.13.3] C BKK79_07875 hypothetical protein K07690 evgA; two-component system, NarL family, response regulator EvgA C BKK79_01270 DNA-binding response regulator K07690 evgA; two-component system, NarL family, response regulator EvgA C BKK79_25910 DNA-binding response regulator K07690 evgA; two-component system, NarL family, response regulator EvgA B DegS-DegU (multicellular behavior control) B DesK-DesR (membrane lipid fluidity regulation) B VraS-VraR (cell-wall peptidoglycan synthesis) B LiaS-LiaR (cell wall stress response) B DevS-DevR (redox response) B NreB-NreC (dissimilatory nitrate/nitrite reduction) B YdfH-YdfI B SalK-SalR B PprA–PprB (biofilm formation) B Unclassified C BKK79_11185 histidine kinase K02480 K02480; two-component system, NarL family, sensor kinase [EC:2.7.13.3] # ASpo family B KinABCDE-Spo0FA (sporulation control) # ACitB family B CitA-CitB (citrate fermentation) B CitS-CitT (magnesium-citrate transport) B DcuS-DcuR (C4-dicarboxylate metabolism) B DctS-DctR (C4-dicarboxylate transport) B MalK-MalR (malate transport) B Unclassified # ALytTR family B LysS-LysR B AlgZ-AlgR (alginate production) B NatK-NatR (sodium extrusion) B AgrC-AgrA (exoprotein synthesis) B AgrC2-AgrA2 (virulence regulation) B ComD-ComE (competence) B Unclassified # ANtrC family B GlnL-GlnG (nitrogen regulation) C BKK79_18400 PAS domain-containing sensor histidine kinase K07708 glnL; two-component system, NtrC family, nitrogen regulation sensor histidine kinase GlnL [EC:2.7.13.3] C BKK79_18405 nitrogen regulation protein NR(I) K07712 glnG; two-component system, NtrC family, nitrogen regulation response regulator GlnG B NtrY-NtrX (nitrogen regulation) C BKK79_11265 PAS domain-containing sensor histidine kinase K13598 ntrY; two-component system, NtrC family, nitrogen regulation sensor histidine kinase NtrY [EC:2.7.13.3] C BKK79_11270 two-component system response regulator K13599 ntrX; two-component system, NtrC family, nitrogen regulation response regulator NtrX B HydH-HydG (metal tolerance) C BKK79_27200 two-component sensor histidine kinase K07709 zraS; two-component system, NtrC family, sensor histidine kinase HydH [EC:2.7.13.3] C BKK79_03700 sigma-54-dependent Fis family transcriptional regulator K07713 zraR; two-component system, NtrC family, response regulator HydG B AtoS-AtoC (cPHB biosynthesis) B PilS-PilR (type 4 fimbriae synthesis) C BKK79_13660 two-component sensor histidine kinase K02668 pilS; two-component system, NtrC family, sensor histidine kinase PilS [EC:2.7.13.3] C BKK79_13665 sigma-54-dependent Fis family transcriptional regulator K02667 pilR; two-component system, NtrC family, response regulator PilR B GlrK-GlrR (amino sugar metabolism) B PgtB-PgtA (phosphoglycerate transport) B DctB-DctD (C4-dicarboxylate transport) C BKK79_08970 two-component sensor histidine kinase K10125 dctB; two-component system, NtrC family, C4-dicarboxylate transport sensor histidine kinase DctB [EC:2.7.13.3] C BKK79_08965 sigma-54-dependent Fis family transcriptional regulator K10126 dctD; two-component system, NtrC family, C4-dicarboxylate transport response regulator DctD B KinB-AlgB (alginate production) B HupT-HupR (hydrogenase synthesis regulation) B Unclassified # ACheA family B CheA-CheYBV (chemotaxis) C BKK79_26395 chemotaxis protein CheA K03407 cheA; two-component system, chemotaxis family, sensor kinase CheA [EC:2.7.13.3] C BKK79_26350 hypothetical protein K03413 cheY; two-component system, chemotaxis family, chemotaxis protein CheY C BKK79_26420 two-component system response regulator K03413 cheY; two-component system, chemotaxis family, chemotaxis protein CheY C BKK79_26415 chemotaxis response regulator protein-glutamate methylesterase K03412 cheB; two-component system, chemotaxis family, protein-glutamate methylesterase/glutaminase [EC:3.1.1.61 3.5.1.44] C BKK79_06220 chemotaxis protein K13924 cheBR; two-component system, chemotaxis family, CheB/CheR fusion protein [EC:2.1.1.80 3.1.1.61] C BKK79_20950 chemotaxis protein K13924 cheBR; two-component system, chemotaxis family, CheB/CheR fusion protein [EC:2.1.1.80 3.1.1.61] C BKK79_01055 chemotaxis protein CheB K13924 cheBR; two-component system, chemotaxis family, CheB/CheR fusion protein [EC:2.1.1.80 3.1.1.61] C BKK79_29825 chemotaxis protein CheV K03415 cheV; two-component system, chemotaxis family, chemotaxis protein CheV B ChpA-ChpB/PilGH (chemosensory) C BKK79_06010 hybrid sensor histidine kinase/response regulator K06596 chpA; chemosensory pili system protein ChpA (sensor histidine kinase/response regulator) C BKK79_06025 two-component system response regulator K02658 pilH; twitching motility two-component system response regulator PilH B PixL-PixGH (positive phototaxis) B WspE-WspRF (chemosensory) C BKK79_23025 hybrid sensor histidine kinase/response regulator K13490 wspE; two-component system, chemotaxis family, sensor histidine kinase and response regulator WspE C BKK79_23035 diguanylate cyclase response regulator K11444 wspR; two-component system, chemotaxis family, response regulator WspR [EC:2.7.7.65] C BKK79_23030 chemotaxis-specific protein-glutamate methylesterase CheB K13491 wspF; two-component system, chemotaxis family, response regulator WspF [EC:3.1.1.61] B Cph1-Rcp1 (light response) # ACell cycle family B PleC-PleD (cell fate control) B CckA-CtrA/CpdR (cell cycle control) B Hk1-Rrp1 (glycerol uptake and utilization) # ALux family B LuxQN/CqsS-LuxU-LuxO (quorum sensing) C BKK79_22205 two-component sensor histidine kinase K10916 cqsS; two-component system, CAI-1 autoinducer sensor kinase/phosphatase CqsS [EC:2.7.13.3 3.1.3.-] # ALuxR family B DctS-DctR (C4-dicarboxylate transport) B TtrS-TtrR (tetrathionate respiration) B FixL-FixJ (nitrogen fixation) C BKK79_10775 hypothetical protein K14986 fixL; two-component system, LuxR family, sensor kinase FixL [EC:2.7.13.3] B SsrA-SsrB # AOther families B FlrB-FlrC (polar flagellar synthesis) B AauS-AauR (acidic amino acids utilization) C BKK79_06480 two-component sensor histidine kinase K17060 aauS; two-component system, sensor histidine kinase AauS [EC:2.7.13.3] C BKK79_06485 Fis family transcriptional regulator K17061 aauR; two-component system, response regulator AauR B SLN1-YPD1-SSK1/SKN7 (osmosensing) B RpfC-RpfG (cell-to-cell signaling) B GlnK-GlnL (glutamine utilization) B HspS-HspR (hexose phosphates uptake) B YesM-YesN B CikA B RegB-RegA (redox response) C BKK79_09545 ATP-binding protein K15011 regB; two-component system, sensor histidine kinase RegB [EC:2.7.13.3] C BKK79_09550 two-component system response regulator K15012 regA; two-component system, response regulator RegA B FitF-FitH (insecticidal toxin regulation) B PhcS-PhcRQ C BKK79_14075 two-component sensor histidine kinase K19621 phcS; two-component system, sensor histidine kinase PhcS [EC:2.7.13.3] C BKK79_14080 hybrid sensor histidine kinase/response regulator K19622 phcR; two-component system, response regulator PhcR C BKK79_14085 hypothetical protein K19623 phcQ; two-component system, probable response regulator PhcQ B SagS-HptB-HsbR (swarming activity and biofilm formation) C BKK79_34755 hybrid sensor histidine kinase/response regulator K20975 K20975; two-component system, sensor histidine kinase [EC:2.7.13.3] B PdtaS-PdtaR B NasS-NasT B Unclassified C BKK79_06755 hypothetical protein K20971 ladS; two-component system, sensor histidine kinase LadS C BKK79_27390 hybrid sensor histidine kinase/response regulator K20971 ladS; two-component system, sensor histidine kinase LadS ! #
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#Last updated: December 14, 2023