+E	Messenger RNA Biogenesis	KO
#<h2><a href="/kegg/brite.html"><img src="/Fig/bget/kegg3.gif" align="middle" border=0></a>&nbsp; Messenger RNA Biogenesis - Dalotia coriaria (greenhouse rove beetle)</h2>
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A<b>Eukaryotic type</b>
B  mRNA processing factors
C    5' end processing
D      Capping factors
E        135794203 Cdk7; (RefSeq) cyclin-dependent kinase 7	K02202 CDK7; cyclin-dependent kinase 7 [EC:2.7.11.22 2.7.11.23] 
D      Cap binding complex
E        135791268 Cbp80; (RefSeq) nuclear cap-binding protein subunit 1	K12882 NCBP1; nuclear cap-binding protein subunit 1 
E        135795981 nuclear cap-binding protein subunit 2	K12883 NCBP2; nuclear cap-binding protein subunit 2 
E        135795982 LOW QUALITY PROTEIN: nuclear cap-binding protein subunit 2-like	K12883 NCBP2; nuclear cap-binding protein subunit 2 
C    3' end processing
D      Pre-mRNA cleavage factor Im (CFIm)
E        135793277 Cpsf5; (RefSeq) cleavage and polyadenylation specificity factor subunit 5	K14397 NUDT21; cleavage and polyadenylation specificity factor subunit 5 
E        135791968 Cpsf6; (RefSeq) cleavage and polyadenylation specificity factor subunit 6 isoform X1	K14398 CPSF6_7; cleavage and polyadenylation specificity factor subunit 6/7 
D      Pre-mRNA cleavage factor IIm (CFIIm)
D      Cleavage and polyadenylation specificity factor (CPSF) complex
E        135794878 CPSF1; (RefSeq) cleavage and polyadenylation specificity factor subunit 1	K14401 CPSF1; cleavage and polyadenylation specificity factor subunit 1 
E        135799722 CPSF2; (RefSeq) LOW QUALITY PROTEIN: probable cleavage and polyadenylation specificity factor subunit 2	K14402 CPSF2; cleavage and polyadenylation specificity factor subunit 2 
E        135799266 Cpsf73; (RefSeq) cleavage and polyadenylation specificity factor 73	K14403 CPSF3; cleavage and polyadenylation specificity factor subunit 3 [EC:3.1.27.-] 
E        135795018 Clp; (RefSeq) LOW QUALITY PROTEIN: cleavage and polyadenylation specificity factor subunit 4	K14404 CPSF4; cleavage and polyadenylation specificity factor subunit 4 
E        135796472 Wdr82; (RefSeq) WD repeat-containing protein 82	K14962 WDR82; COMPASS component SWD2 
E        135792843 serine/threonine-protein phosphatase PP1-beta catalytic subunit isoform X1	K06269 PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit [EC:3.1.3.16] 
E        135798993 serine/threonine-protein phosphatase alpha-2 isoform	K06269 PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit [EC:3.1.3.16] 
E        135796527 RNA polymerase II subunit A C-terminal domain phosphatase SSU72-like	K15544 SSU72; RNA polymerase II subunit A C-terminal domain phosphatase SSU72 [EC:3.1.3.16] 
E        135802045 RNA polymerase II subunit A C-terminal domain phosphatase SSU72-like	K15544 SSU72; RNA polymerase II subunit A C-terminal domain phosphatase SSU72 [EC:3.1.3.16] 
D      Cleavage stimulation factor (CSTF) complex
E        135795398 CstF50; (RefSeq) cleavage stimulation factor subunit 1	K14406 CSTF1; cleavage stimulation factor subunit 1 
E        135799492 su(f); (RefSeq) protein suppressor of forked isoform X1	K14408 CSTF3; cleavage stimulation factor subunit 3 
D      U7-dependent histone pre-mRNA processing factors
E        135796112 SmB; (RefSeq) small nuclear ribonucleoprotein-associated protein B	K11086 SNRPB; small nuclear ribonucleoprotein B and B' 
E        135803451 SmD3; (RefSeq) small nuclear ribonucleoprotein Sm D3	K11088 SNRPD3; small nuclear ribonucleoprotein D3 
E        135789459 probable small nuclear ribonucleoprotein E	K11097 SNRPE; small nuclear ribonucleoprotein E 
E        135794895 probable small nuclear ribonucleoprotein E	K11097 SNRPE; small nuclear ribonucleoprotein E 
E        135796450 SmF; (RefSeq) small nuclear ribonucleoprotein F	K11098 SNRPF; small nuclear ribonucleoprotein F 
E        135789982 SNRPG; (RefSeq) probable small nuclear ribonucleoprotein G	K11099 SNRPG; small nuclear ribonucleoprotein G 
E        135799722 CPSF2; (RefSeq) LOW QUALITY PROTEIN: probable cleavage and polyadenylation specificity factor subunit 2	K14402 CPSF2; cleavage and polyadenylation specificity factor subunit 2 
E        135799266 Cpsf73; (RefSeq) cleavage and polyadenylation specificity factor 73	K14403 CPSF3; cleavage and polyadenylation specificity factor subunit 3 [EC:3.1.27.-] 
D      DRB sensitivity inducing factor (DSIF) complex
E        135802817 spt4; (RefSeq) transcription elongation factor SPT4-A	K15171 SUPT4H1; transcription elongation factor SPT4 
E        135803460 Spt5; (RefSeq) transcription elongation factor SPT5	K15172 SUPT5H; transcription elongation factor SPT5 
D      N6-methyltransferase complex
E        135799438 Mettl14; (RefSeq) N6-adenosine-methyltransferase non-catalytic subunit	K23960 METTL14; mRNA m6A methyltransferase non-catalytic subunit 
E        135798080 nito; (RefSeq) RNA-binding protein spenito	K13190 RBM15; RNA-binding protein 15 
D      Poly(A) addition factors
D      Negative regulators of mRNA 3' end processing
E        135803213 TAR DNA-binding protein 43-like isoform X1	K23600 TARDBP; TAR DNA-binding protein 43 
C    Other processing factors
B  mRNA surveillance and transport factors
C    Transport factors
D      EJC complex
E        135797877 tsu; (RefSeq) RNA-binding protein 8A	K12876 RBM8A; RNA-binding protein 8A 
E        135801534 mago; (RefSeq) protein mago nashi	K12877 MAGOH; protein mago nashi 
E        135798159 eukaryotic initiation factor 4A-III	K13025 EIF4A3; ATP-dependent RNA helicase [EC:5.6.2.7] 
E        135791017 coiled-coil domain-containing protein 174	K25178 CCDC174; coiled-coil domain-containing protein 174 
D      TREX complex
E        135794071 THO complex subunit 3-like	K12880 THOC3; THO complex subunit 3 
E        135794072 LOW QUALITY PROTEIN: THO complex subunit 3-like	K12880 THOC3; THO complex subunit 3 
D      TREX-2 complex
D      Nuclear pore complex
E        135798733 Rae1; (RefSeq) protein Rae1	K14298 RAE1; mRNA export factor 
E        135798261 Sec13; (RefSeq) protein SEC13 homolog	K14004 SEC13; protein transport protein SEC13 
D      Ran-mediated transport factors
E        135804013 Ran; (RefSeq) GTP-binding nuclear protein Ran	K07936 RAN; GTP-binding nuclear protein Ran 
E        135797537 ELAV-like protein 3 isoform X1	K13208 ELAVL2_3_4; ELAV like protein 2/3/4 
E        135798087 transitional endoplasmic reticulum ATPase TER94	K13525 VCP; transitional endoplasmic reticulum ATPase 
E        135801757 transitional endoplasmic reticulum ATPase TER94	K13525 VCP; transitional endoplasmic reticulum ATPase 
E        135803559 emb; (RefSeq) exportin-1	K14290 XPO1; exportin-1 
E        135800406 Ranbp16; (RefSeq) exportin-7 isoform X1	K18460 XPO7; exportin-7 
D      eIF4F and regulatory proteins
E        135795302 eukaryotic initiation factor 4A-I-like	K03257 EIF4A; translation initiation factor 4A 
E        135797683 Sra-1; (RefSeq) cytoplasmic FMR1-interacting protein	K05749 CYFIP; cytoplasmic FMR1 interacting protein 
E        135795406 bel; (RefSeq) ATP-dependent RNA helicase DDX3X	K11594 DDX3X; ATP-dependent RNA helicase DDX3X [EC:5.6.2.7] 
E        135797467 pAbp; (RefSeq) polyadenylate-binding protein 4-like isoform X1	K13126 PABPC; polyadenylate-binding protein 
E        135801300 polyadenylate-binding protein 4-like	K13126 PABPC; polyadenylate-binding protein 
E        135792960 MCTS1; (RefSeq) malignant T-cell-amplified sequence 1 homolog	K07575 MCTS; malignant T-cell-amplified sequence 
E        135791902 DENR; (RefSeq) density-regulated protein homolog	K24272 DENR; density-regulated protein 
D      APOBEC1-ACF complex
D      Other transport factors
E        135789838 Rbp6; (RefSeq) RNA-binding protein Musashi homolog Rbp6 isoform X1	K14411 MSI; RNA-binding protein Musashi 
E        135789686 protein pelota-like	K06965 PELO; protein pelota 
E        135801720 LOW QUALITY PROTEIN: protein pelota-like	K06965 PELO; protein pelota 
E        135798643 polyadenylate-binding protein 2-like isoform X1	K14396 PABPN1; polyadenylate-binding protein 2 
E        135801788 LOW QUALITY PROTEIN: polyadenylate-binding protein 2-like	K14396 PABPN1; polyadenylate-binding protein 2 
E        135795715 fand; (RefSeq) pre-mRNA-splicing factor syf1 homolog	K12867 SYF1; pre-mRNA-splicing factor SYF1 
E        135799952 Pur-alpha; (RefSeq) transcriptional regulator protein Pur-beta isoform X1	K21772 PURA; transcriptional activator protein Pur-alpha 
C    Surveillance factors
D      Surveillance complex
E        135801476 eRF1; (RefSeq) eukaryotic peptide chain release factor subunit 1 isoform X1	K03265 ETF1; peptide chain release factor subunit 1 
E        135796560 eRF3; (RefSeq) LOW QUALITY PROTEIN: eukaryotic peptide chain release factor GTP-binding subunit ERF3A	K03267 ERF3; peptide chain release factor subunit 3 
E        135800227 Upf1; (RefSeq) regulator of nonsense transcripts 1 homolog	K14326 UPF1; regulator of nonsense transcripts 1 [EC:5.6.2.5 5.6.2.3] 
D      Protein phosphatase 2A
E        135799132 mts; (RefSeq) serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	K04382 PPP2C; serine/threonine-protein phosphatase 2A catalytic subunit [EC:3.1.3.16] 
E        135789342 Pp2A-29B; (RefSeq) serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform	K03456 PPP2R1; serine/threonine-protein phosphatase 2A regulatory subunit A 
E        135789694 tws; (RefSeq) protein phosphatase PP2A 55 kDa regulatory subunit isoform X1	K04354 PPP2R2; serine/threonine-protein phosphatase 2A regulatory subunit B 
E        135799537 wdb; (RefSeq) serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform	K11584 PPP2R5; serine/threonine-protein phosphatase 2A regulatory subunit B' 
D      Other surveillance factors
C    Factors involved in mRNA localization
D      Cargo complex
D      Factors that have mRNA localization signals
E        135794841 actin, muscle	K05692 ACTB_G1; actin beta/gamma 1 
E        135799359 actin-5C	K05692 ACTB_G1; actin beta/gamma 1 
E        135794085 enhancer of split mbeta protein-like	K09090 HESN; hairy and enhancer of split, invertebrate 
D      Trans-acting binding proteins
E        135796176 elongation factor 1-alpha-like	K03231 EEF1A; elongation factor 1-alpha 
E        135797635 elongation factor 1-alpha	K03231 EEF1A; elongation factor 1-alpha 
E        135789572 heph; (RefSeq) polypyrimidine tract-binding protein 2 isoform X1	K13218 PTBP1; polypyrimidine tract-binding protein 1 
D      Other mRNA localization factors
E        135797683 Sra-1; (RefSeq) cytoplasmic FMR1-interacting protein	K05749 CYFIP; cytoplasmic FMR1 interacting protein 
E        135790230 poly(rC)-binding protein 3-like isoform X1	K21444 PCBP3_4; poly(rC)-binding protein 3/4 
E        135801622 poly(rC)-binding protein 3-like isoform X1	K21444 PCBP3_4; poly(rC)-binding protein 3/4 
E        135795633 yps; (RefSeq) Y-box factor homolog isoform X1	K09276 YBX1; Y-box-binding protein 1 
C    mRNA cycle factors
D      Common to processing body (P body) and stress granule
E        135795007 AGO1; (RefSeq) protein argonaute-2 isoform X1	K11593 ELF2C; eukaryotic translation initiation factor 2C 
E        135800227 Upf1; (RefSeq) regulator of nonsense transcripts 1 homolog	K14326 UPF1; regulator of nonsense transcripts 1 [EC:5.6.2.5 5.6.2.3] 
E        135795406 bel; (RefSeq) ATP-dependent RNA helicase DDX3X	K11594 DDX3X; ATP-dependent RNA helicase DDX3X [EC:5.6.2.7] 
E        135791901 me31B; (RefSeq) ATP-dependent RNA helicase me31b	K12614 DDX6; ATP-dependent RNA helicase DDX6/DHH1 [EC:5.6.2.7] 
E        135800256 RNA-binding protein MEX3B	K15686 MEX3; RNA-binding protein MEX3 [EC:2.3.2.27] 
E        135795633 yps; (RefSeq) Y-box factor homolog isoform X1	K09276 YBX1; Y-box-binding protein 1 
E        135797640 Tnpo; (RefSeq) transportin-1	K18752 TNPO1; transportin-1 
E        135790320 Pka-C1; (RefSeq) cAMP-dependent protein kinase catalytic subunit 1	K04345 PKA; protein kinase A [EC:2.7.11.11] 
D      P-body specific factors
E        135800393 LSm1; (RefSeq) U6 snRNA-associated Sm-like protein LSm1	K12620 LSM1; U6 snRNA-associated Sm-like protein LSm1 
E        135793562 U6 snRNA-associated Sm-like protein LSm2	K12621 LSM2; U6 snRNA-associated Sm-like protein LSm2 
E        135802289 U6 snRNA-associated Sm-like protein LSm2	K12621 LSM2; U6 snRNA-associated Sm-like protein LSm2 
E        135789316 LSm3; (RefSeq) U6 snRNA-associated Sm-like protein LSm3	K12622 LSM3; U6 snRNA-associated Sm-like protein LSm3 
E        135796621 U6 snRNA-associated Sm-like protein LSm4	K12623 LSM4; U6 snRNA-associated Sm-like protein LSm4 
E        135802937 U6 snRNA-associated Sm-like protein LSm4	K12623 LSM4; U6 snRNA-associated Sm-like protein LSm4 
E        135795026 U6 snRNA-associated Sm-like protein LSm5	K12624 LSM5; U6 snRNA-associated Sm-like protein LSm5 
E        135798904 U6 snRNA-associated Sm-like protein LSm6	K12625 LSM6; U6 snRNA-associated Sm-like protein LSm6 
E        135796346 LSm7; (RefSeq) U6 snRNA-associated Sm-like protein LSm7	K12626 LSM7; U6 snRNA-associated Sm-like protein LSm7 
E        135799455 U6 snRNA-associated Sm-like protein LSm8	K12627 LSM8; U6 snRNA-associated Sm-like protein LSm8 
E        135792904 Klc; (RefSeq) kinesin light chain isoform X1	K10407 KLC; kinesin light chain 
E        135790201 tubulin alpha chain-like	K07374 TUBA; tubulin alpha 
E        135790943 tubulin alpha-1 chain	K07374 TUBA; tubulin alpha 
E        135793808 tubulin alpha-1 chain-like	K07374 TUBA; tubulin alpha 
E        135800268 tubulin alpha-1 chain-like	K07374 TUBA; tubulin alpha 
E        135801367 tubulin alpha-1 chain-like	K07374 TUBA; tubulin alpha 
E        135799084 Rga; (RefSeq) CCR4-NOT transcription complex subunit 2 isoform X1	K12605 CNOT2; CCR4-NOT transcription complex subunit 2 
E        135800511 twin; (RefSeq) CCR4-NOT transcription complex subunit 6-like isoform X1	K12603 CNOT6; CCR4-NOT transcription complex subunit 6 [EC:3.1.13.4] 
E        135792529 Pop2; (RefSeq) CCR4-NOT transcription complex subunit 7	K12581 CNOT7_8; CCR4-NOT transcription complex subunit 7/8 
E        135803778 protein Tob1-like	K14443 TOB; protein Tob/BTG 
E        135796199 Rpb7; (RefSeq) DNA-directed RNA polymerase II subunit RPB7	K03015 RPB7; DNA-directed RNA polymerase II subunit RPB7 
D      Stress granule specific factors
E        135797194 nucleolysin TIAR isoform X1	K13201 TIA1; nucleolysin TIA-1/TIAR 
E        135798121 Rox8; (RefSeq) cytotoxic granule associated RNA binding protein TIA1	K13201 TIA1; nucleolysin TIA-1/TIAR 
E        135797467 pAbp; (RefSeq) polyadenylate-binding protein 4-like isoform X1	K13126 PABPC; polyadenylate-binding protein 
E        135801300 polyadenylate-binding protein 4-like	K13126 PABPC; polyadenylate-binding protein 
E        135800467 eIF3b; (RefSeq) eukaryotic translation initiation factor 3 subunit B	K03253 EIF3B; translation initiation factor 3 subunit B 
E        135795302 eukaryotic initiation factor 4A-I-like	K03257 EIF4A; translation initiation factor 4A 
E        135798159 eukaryotic initiation factor 4A-III	K13025 EIF4A3; ATP-dependent RNA helicase [EC:5.6.2.7] 
E        135801230 S6kII; (RefSeq) ribosomal protein S6 kinase 2 beta isoform X1	K04373 RPS6KA; ribosomal protein S6 kinase alpha-1/2/3/6 [EC:2.7.11.1] 
E        135791343 Rack1; (RefSeq) small ribosomal subunit protein RACK1	K14753 RACK1; guanine nucleotide-binding protein subunit beta-2-like 1 protein 
B  mRNA degradation factors
C    5'-3' decay
D      Decapping complex
E        135791901 me31B; (RefSeq) ATP-dependent RNA helicase me31b	K12614 DDX6; ATP-dependent RNA helicase DDX6/DHH1 [EC:5.6.2.7] 
D      Lsm complex
E        135800393 LSm1; (RefSeq) U6 snRNA-associated Sm-like protein LSm1	K12620 LSM1; U6 snRNA-associated Sm-like protein LSm1 
E        135793562 U6 snRNA-associated Sm-like protein LSm2	K12621 LSM2; U6 snRNA-associated Sm-like protein LSm2 
E        135802289 U6 snRNA-associated Sm-like protein LSm2	K12621 LSM2; U6 snRNA-associated Sm-like protein LSm2 
E        135789316 LSm3; (RefSeq) U6 snRNA-associated Sm-like protein LSm3	K12622 LSM3; U6 snRNA-associated Sm-like protein LSm3 
E        135796621 U6 snRNA-associated Sm-like protein LSm4	K12623 LSM4; U6 snRNA-associated Sm-like protein LSm4 
E        135802937 U6 snRNA-associated Sm-like protein LSm4	K12623 LSM4; U6 snRNA-associated Sm-like protein LSm4 
E        135795026 U6 snRNA-associated Sm-like protein LSm5	K12624 LSM5; U6 snRNA-associated Sm-like protein LSm5 
E        135798904 U6 snRNA-associated Sm-like protein LSm6	K12625 LSM6; U6 snRNA-associated Sm-like protein LSm6 
E        135796346 LSm7; (RefSeq) U6 snRNA-associated Sm-like protein LSm7	K12626 LSM7; U6 snRNA-associated Sm-like protein LSm7 
E        135799455 U6 snRNA-associated Sm-like protein LSm8	K12627 LSM8; U6 snRNA-associated Sm-like protein LSm8 
D      5' exonucleases
D      Other 5'-3' decay factors
C    3'-5' decay
D      Core exosome factors
E        135800388 Rrp4; (RefSeq) exosome complex component RRP4	K03679 RRP4; exosome complex component RRP4 
E        135799709 Ski6; (RefSeq) exosome complex component RRP41	K11600 RRP41; exosome complex component RRP41 
D      Exosome cofactors
D      TRAMP complex
D      Ski complex
E        135790476 superkiller complex protein 8	K12602 WDR61; WD repeat-containing protein 61 
D      Ccr4-NOT complex
E        135800511 twin; (RefSeq) CCR4-NOT transcription complex subunit 6-like isoform X1	K12603 CNOT6; CCR4-NOT transcription complex subunit 6 [EC:3.1.13.4] 
E        135799084 Rga; (RefSeq) CCR4-NOT transcription complex subunit 2 isoform X1	K12605 CNOT2; CCR4-NOT transcription complex subunit 2 
E        135792529 Pop2; (RefSeq) CCR4-NOT transcription complex subunit 7	K12581 CNOT7_8; CCR4-NOT transcription complex subunit 7/8 
E        135796699 Rcd-1; (RefSeq) CCR4-NOT transcription complex subunit 9	K12606 RCD1; CCR4-NOT transcription complex subunit 9 
D      Pan complex
D      Other 3'-5' decay factors
E        135803778 protein Tob1-like	K14443 TOB; protein Tob/BTG 
C    Other degradation factors
D      RNases
#
A<b>Prokaryotic type</b>
B  Bacterial mRNA degradation factors
C    RNA degradosome components
D      Ribonucreases
D      Helicases
D      Other RNA degradosome components
E        135789331 Eno; (RefSeq) LOW QUALITY PROTEIN: enolase	K01689 ENO1_2_3; enolase 1/2/3 [EC:4.2.1.11] 
C    Other RNA degradation factors
D      Chaperones
E        135800503 Hsc70-5; (RefSeq) heat shock 70 kDa protein cognate 5	K04043 dnaK; molecular chaperone DnaK 
E        135796317 Hsp60A; (RefSeq) heat shock protein 60A	K04077 groEL; chaperonin GroEL [EC:5.6.1.7] 
D      Others
D      Bacterial Small RNA Regulators
B  Archeal mRNA degradation factors
C    Exosome components
D      Core exosome
E        135800388 Rrp4; (RefSeq) exosome complex component RRP4	K03679 RRP4; exosome complex component RRP4 
D      Cofactors
E        135799709 Ski6; (RefSeq) exosome complex component RRP41	K11600 RRP41; exosome complex component RRP41 
D      Others
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#Last updated: August 27, 2025