+E Replication protein KO
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DNA Replication Proteins - Dermatophagoides farinae (American house dust mite)
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AEukaryotic type
B DNA Replication Initiation Factors
C pre-RC (pre-replication complex)
D 124492680 origin recognition complex subunit 1-like K02603 ORC1; origin recognition complex subunit 1
D 124494298 origin recognition complex subunit 2-like K02604 ORC2; origin recognition complex subunit 2
D 124491037 LOW QUALITY PROTEIN: uncharacterized protein LOC124491037 K02605 ORC3; origin recognition complex subunit 3
D 124493572 uncharacterized protein LOC124493572 K02606 ORC4; origin recognition complex subunit 4
D 124498645 origin recognition complex subunit 5-like K02607 ORC5; origin recognition complex subunit 5
D 124494527 DNA replication factor Cdt1-like K10727 CDT1; chromatin licensing and DNA replication factor 1
D 124496588 LOW QUALITY PROTEIN: cell division control protein 6 homolog K02213 CDC6; cell division control protein 6
D 124494070 DNA replication licensing factor mcm2-like K02540 MCM2; DNA replication licensing factor MCM2 [EC:5.6.2.3]
D 124490574 DNA replication licensing factor MCM3-like K02541 MCM3; DNA replication licensing factor MCM3 [EC:5.6.2.3]
D 124495362 DNA replication licensing factor MCM4-like K02212 MCM4; DNA replication licensing factor MCM4 [EC:5.6.2.3]
D 124498482 DNA replication licensing factor mcm5-A-like K02209 MCM5; DNA replication licensing factor MCM5 [EC:5.6.2.3]
D 124495435 DNA replication licensing factor MCM6-like K02542 MCM6; DNA replication licensing factor MCM6 [EC:5.6.2.3]
D 124492828 DNA replication licensing factor mcm7-B-like K02210 MCM7; DNA replication licensing factor MCM7 [EC:5.6.2.3]
C CDK (cyclin dependent kinase)
D 124491472 uncharacterized protein LOC124491472 K06627 CCNA; cyclin-A
D 124494333 LOW QUALITY PROTEIN: G2/mitotic-specific cyclin-A-like K06627 CCNA; cyclin-A
D 124492462 G1/S-specific cyclin-E1-like K06626 CCNE; G1/S-specific cyclin-E1
C DDK (Dbf-4 dependent kinase)
D 124492583 cell division cycle 7-related protein kinase-like K02214 CDC7; cell division control protein 7 [EC:2.7.11.1]
C GINS complex
D 124494775 DNA replication complex GINS protein PSF1-like K10732 GINS1; GINS complex subunit 1
D 124495928 DNA replication complex GINS protein PSF2-like K10733 GINS2; GINS complex subunit 2
D 124492784 DNA replication complex GINS protein PSF3-like K10734 GINS3; GINS complex subunit 3
D 124492742 DNA replication complex GINS protein SLD5-like K10735 GINS4; GINS complex subunit 4
C Other initiation factors
D 124491449 uncharacterized protein LOC124491449 K10728 TOPBP1; topoisomerase (DNA) II binding protein 1
D 124499002 ATP-dependent DNA helicase Q4-like K10730 RECQL4; ATP-dependent DNA helicase Q4 [EC:5.6.2.4]
D 124492130 cell division control protein 45 homolog K06628 CDC45; cell division control protein 45
D 124494789 protein MCM10 homolog K10736 MCM10; minichromosome maintenance protein 10
B DNA Replication Elongation Factors
C DNA polymerase alpha / primase complex
D 124489909 DNA polymerase alpha catalytic subunit-like K02320 POLA1; DNA polymerase alpha subunit A [EC:2.7.7.7]
D 124491827 DNA polymerase alpha subunit B-like K02321 POLA2; DNA polymerase alpha subunit B
D 124497026 DNA primase small subunit-like K02684 PRI1; DNA primase small subunit [EC:2.7.7.102]
D 124493397 DNA primase large subunit-like K02685 PRI2; DNA primase large subunit
C DNA polymerase epsilon complex
D 124500038 DNA polymerase epsilon subunit 2-like K02325 POLE2; DNA polymerase epsilon subunit 2 [EC:2.7.7.7]
D 124493497 DNA polymerase epsilon subunit 3-like K02326 POLE3; DNA polymerase epsilon subunit 3 [EC:2.7.7.7]
C DNA polymerase delta complex
D 124490598 DNA polymerase delta catalytic subunit-like K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
D 124495537 DNA polymerase delta subunit 2-like K02328 POLD2; DNA polymerase delta subunit 2
C DNA polymerase gamma complex (mitochondrial)
D 124499490 DNA polymerase subunit gamma-1, mitochondrial-like K02332 POLG; DNA polymerase gamma 1 [EC:2.7.7.7]
D 124496209 DNA polymerase subunit gamma-2, mitochondrial-like K02333 POLG2; DNA polymerase gamma 2
C RPA (replication protein A)
D 124499323 replication factor A protein 1-like K07466 RFA1; replication factor A1
D 124490393 replication protein A 32 kDa subunit-like K10739 RFA2; replication factor A2
D 124500046 replication protein A 32 kDa subunit-like isoform X1 K10739 RFA2; replication factor A2
C RFC (replication factor C)
D 124498362 replication factor C subunit 1-like K10754 RFC1; replication factor C subunit 1
D 124494091 replication factor C subunit 4-like K10755 RFC2_4; replication factor C subunit 2/4
D 124496994 replication factor C subunit 2-like K10755 RFC2_4; replication factor C subunit 2/4
D 124494246 replication factor C subunit 5-like K10756 RFC3_5; replication factor C subunit 3/5
D 124499806 replication factor C subunit 3-like K10756 RFC3_5; replication factor C subunit 3/5
C RNase H
D 124497590 ribonuclease H1-like K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
D 124499452 ribonuclease H1-like K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
D 124490813 ribonuclease H2 subunit A-like K10743 RNASEH2A; ribonuclease H2 subunit A [EC:3.1.26.4]
D 124493159 ribonuclease H2 subunit B-like isoform X1 K10744 RNASEH2B; ribonuclease H2 subunit B
C Other elongation factors
D 124497215 proliferating cell nuclear antigen-like K04802 PCNA; proliferating cell nuclear antigen
D 124496545 LOW QUALITY PROTEIN: DNA replication ATP-dependent helicase/nuclease DNA2-like K10742 DNA2; DNA replication ATP-dependent helicase/nuclease Dna2 [EC:5.6.2.3 3.1.-.-]
D 124496872 LOW QUALITY PROTEIN: DNA replication ATP-dependent helicase/nuclease DNA2-like K10742 DNA2; DNA replication ATP-dependent helicase/nuclease Dna2 [EC:5.6.2.3 3.1.-.-]
D 124491295 flap endonuclease 1-like K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
D 124500034 exonuclease 1-like K10746 EXO1; exonuclease 1 [EC:3.1.-.-]
D 124496173 DNA ligase 1-like K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
B DNA Replication Termination Factors
C DNA methylation enzymes
D 124498664 DNA (cytosine-5)-methyltransferase PliMCI-like K00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]
C Prevention of re-replication factors
D 124497910 LOW QUALITY PROTEIN: G2/mitotic-specific cyclin-B-like K21770 CCNB2; G2/mitotic-specific cyclin-B2
D 124498166 G2/mitotic-specific cyclin-B3-like K21771 CCNB3; G2/mitotic-specific cyclin-B3
D 124496701 cyclin-dependent kinase 1-like K02087 CDK1; cyclin-dependent kinase 1 [EC:2.7.11.22 2.7.11.23]
C Telomere proteins
D Shelterin complex
E 124493146 uncharacterized protein LOC124493146 K11109 POT1; protection of telomeres protein 1
D TERB1-TERB2-MAJIN complex
D CST complex (animals)
D CST complex (yeast)
D RIF proteins
D SIR proteins
C Telomerase complex (animals)
D 124499290 telomerase-binding protein EST1A-like K11124 SMG6; protein SMG6 [EC:3.1.-.-]
D 124494213 LOW QUALITY PROTEIN: uncharacterized protein LOC124494213 K11125 SMG5; protein SMG5
D 124492687 LOW QUALITY PROTEIN: telomerase reverse transcriptase-like K11126 TERT; telomerase reverse transcriptase [EC:2.7.7.49]
D Dyskerin complex
E 124495265 H/ACA ribonucleoprotein complex subunit 1-like K11128 GAR1; H/ACA ribonucleoprotein complex subunit 1
E 124493124 H/ACA ribonucleoprotein complex subunit 2-like protein K11129 NHP2; H/ACA ribonucleoprotein complex subunit 2
E 124493144 H/ACA ribonucleoprotein complex subunit 3-like K11130 NOP10; H/ACA ribonucleoprotein complex subunit 3
E 124494702 H/ACA ribonucleoprotein complex subunit 4-like K11131 DKC1; H/ACA ribonucleoprotein complex subunit 4 [EC:5.4.99.-]
C Telomerase complex (fungi)
D 124492687 LOW QUALITY PROTEIN: telomerase reverse transcriptase-like K11126 TERT; telomerase reverse transcriptase [EC:2.7.7.49]
D Sm core complex
E 124491544 small nuclear ribonucleoprotein-associated protein B-like K11086 SNRPB; small nuclear ribonucleoprotein B and B'
E 124494393 probable small nuclear ribonucleoprotein Sm D1 K11087 SNRPD1; small nuclear ribonucleoprotein D1
E 124493203 small nuclear ribonucleoprotein Sm D2 K11096 SNRPD2; small nuclear ribonucleoprotein D2
E 124497274 small nuclear ribonucleoprotein Sm D3-like K11088 SNRPD3; small nuclear ribonucleoprotein D3
E 124490782 small nuclear ribonucleoprotein F K11098 SNRPF; small nuclear ribonucleoprotein F
E 124496258 small nuclear ribonucleoprotein G-like K11099 SNRPG; small nuclear ribonucleoprotein G
C ELG1-RFC complex
D 124494091 replication factor C subunit 4-like K10755 RFC2_4; replication factor C subunit 2/4
D 124496994 replication factor C subunit 2-like K10755 RFC2_4; replication factor C subunit 2/4
D 124494246 replication factor C subunit 5-like K10756 RFC3_5; replication factor C subunit 3/5
D 124499806 replication factor C subunit 3-like K10756 RFC3_5; replication factor C subunit 3/5
C MRN complex
D 124494941 double-strand break repair protein MRE11-like K10865 MRE11; double-strand break repair protein MRE11
D 124499634 LOW QUALITY PROTEIN: DNA repair protein RAD50-like K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
C Other termination factors
D 124494683 Bloom syndrome protein homolog K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
D 124494132 DNA repair endonuclease XPF-like K10848 ERCC4; DNA excision repair protein ERCC-4 [EC:3.1.-.-]
D 124490269 poly [ADP-ribose] polymerase-like K24070 PARP1; poly [ADP-ribose] polymerase 1 [EC:2.4.2.30]
D 124497023 LOW QUALITY PROTEIN: poly [ADP-ribose] polymerase tankyrase-2-like K10799 TNKS; tankyrase [EC:2.4.2.30]
D 124495665 PIN2/TERF1-interacting telomerase inhibitor 1-like K11135 PINX1; Pin2-interacting protein X1
D 124497298 LOW QUALITY PROTEIN: Fanconi anemia group J protein-like K11136 RTEL1; regulator of telomere elongation helicase 1 [EC:5.6.2.3]
D 124493140 telomere length regulation protein TEL2 homolog isoform X1 K11137 TELO2; telomere length regulation protein
D 124493111 telomerase RNA component interacting RNase-like K01149 TRIR; telomerase RNA component interacting RNase [EC:3.1.13.-]
D 124492535 ATP-dependent DNA helicase PIF1-like K15255 PIF1; ATP-dependent DNA helicase PIF1 [EC:5.6.2.3]
D 124495858 transcriptional activator protein Pur-beta-like K21772 PURA; transcriptional activator protein Pur-alpha
D 124492216 telomerase Cajal body protein 1-like K23314 WRAP53; telomerase Cajal body protein 1
D 124499079 replication stress response regulator SDE2-like isoform X1 K25059 SDE2; replication stress response regulator SDE2
D 124499534 replication termination factor 2-like K25186 RTF2; replication termination factor 2
B DNA Topoisomerases
C 124500279 DNA topoisomerase 1-like K03163 TOP1; DNA topoisomerase I [EC:5.6.2.1]
C 124494660 LOW QUALITY PROTEIN: DNA topoisomerase 2-alpha-like K03164 TOP2; DNA topoisomerase II [EC:5.6.2.2]
C 124495093 LOW QUALITY PROTEIN: DNA topoisomerase 2-alpha-like K03164 TOP2; DNA topoisomerase II [EC:5.6.2.2]
C 124496942 DNA topoisomerase 2-alpha-like K03164 TOP2; DNA topoisomerase II [EC:5.6.2.2]
C 124496543 DNA topoisomerase 3-alpha-like K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
C 124497614 DNA topoisomerase 3-beta-1-like isoform X1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
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AProkaryotic type
B DNA Replication Initiation Factors
C Initiation factors (bacterial)
D 124490975 single-stranded DNA-binding protein, mitochondrial-like K03111 ssb; single-strand DNA-binding protein
D 124490986 single-stranded DNA-binding protein, mitochondrial-like K03111 ssb; single-strand DNA-binding protein
C Initiation factors (archaeal)
B DNA Replication Elongation Factors
C Elongation factors (bacterial)
D DNA polymerase III holoenzyme
D RNase H
E 124497590 ribonuclease H1-like K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
E 124499452 ribonuclease H1-like K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
D Other elongation factors
C Elongation factors (archaeal)
D B-family DNA polymerases
D D-family DNA polymerases
D RNase H
E 124497590 ribonuclease H1-like K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
E 124499452 ribonuclease H1-like K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
D RFC (replication factor C)
D Other elongation factors
E 124496545 LOW QUALITY PROTEIN: DNA replication ATP-dependent helicase/nuclease DNA2-like K10742 DNA2; DNA replication ATP-dependent helicase/nuclease Dna2 [EC:5.6.2.3 3.1.-.-]
E 124496872 LOW QUALITY PROTEIN: DNA replication ATP-dependent helicase/nuclease DNA2-like K10742 DNA2; DNA replication ATP-dependent helicase/nuclease Dna2 [EC:5.6.2.3 3.1.-.-]
E 124491295 flap endonuclease 1-like K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
E 124496173 DNA ligase 1-like K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
B DNA Replication Termination Factors
C Terminus site-binding protein
C DNA methylation enzymes
C Prevention of re-replication factors
B DNA Topoisomerases
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: August 27, 2025