+F Repair protein KO
#
DNA Repair and Recombination Proteins - Drosophila hydei
%
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AEukaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D 111595219 activating signal cointegrator 1 complex subunit 3 K18663 ASCC3; activating signal cointegrator complex subunit 3 [EC:5.6.2.4]
D 111599908 deoxyribodipyrimidine photo-lyase-like isoform X1 K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]
C BER (base exicision repair)
D DNA glycosylases
E 111593706 uncharacterized protein LOC111593706 K20813 TDG; thymine-DNA glycosylase [EC:3.2.2.29]
E 111601474 single-strand selective monofunctional uracil-DNA glycosylase K10800 SMUG1; single-strand selective monofunctional uracil DNA glycosylase [EC:3.2.2.-]
E 111597116 N-glycosylase/DNA lyase K03660 OGG1; N-glycosylase/DNA lyase [EC:3.2.2.- 4.2.99.18]
E 111599003 endonuclease III-like protein 1 K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
E 111603884 recombination repair protein 1 isoform X1 K10771 APEX1; AP endonuclease 1 [EC:3.1.11.2]
D Long Patch-BER factors
E DNA polymerase delta complex
F 111598094 DNA polymerase delta catalytic subunit K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
F 111596855 DNA polymerase delta small subunit K02328 POLD2; DNA polymerase delta subunit 2
F 111602241 glutamic acid-rich protein K03504 POLD3; DNA polymerase delta subunit 3
E DNA polymerase epsilon complex
F 111598658 DNA polymerase epsilon catalytic subunit A K02324 POLE; DNA polymerase epsilon subunit 1 [EC:2.7.7.7]
F 111594843 DNA polymerase epsilon subunit 2 K02325 POLE2; DNA polymerase epsilon subunit 2 [EC:2.7.7.7]
F 111603960 DNA polymerase epsilon subunit 3 K02326 POLE3; DNA polymerase epsilon subunit 3 [EC:2.7.7.7]
F 111595244 DNA polymerase epsilon subunit 4 K03506 POLE4; DNA polymerase epsilon subunit 4 [EC:2.7.7.7]
E 111594352 proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
E 111593598 proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
E 111601246 flap endonuclease 1 K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
D Short Patch-BER factors
E 111593441 DNA repair protein XRCC1 K10803 XRCC1; DNA-repair protein XRCC1
E 111598530 DNA ligase 3 K10776 LIG3; DNA ligase 3 [EC:6.5.1.1]
D Other BER factors
E 111599106 probable tyrosyl-DNA phosphodiesterase K10862 TDP1; tyrosyl-DNA phosphodiesterase 1 [EC:3.1.4.-]
E 111596201 aprataxin-like protein K10863 APTX; aprataxin [EC:3.6.1.70 3.6.1.71 3.6.1.72]
E 111596208 aprataxin-like protein K10863 APTX; aprataxin [EC:3.6.1.70 3.6.1.71 3.6.1.72]
E 111595926 aprataxin and PNK-like factor isoform X1 K13295 APLF; aprataxin and PNK-like factor [EC:3.1.-.-]
E 111602768 uncharacterized protein F21D5.5 K08073 PNKP; bifunctional polynucleotide phosphatase/kinase [EC:3.1.3.32 2.7.1.78]
E 111595352 high mobility group protein DSP1 isoform X1 K10802 HMGB1; high mobility group protein B1
E 111598505 poly [ADP-ribose] polymerase K24070 PARP1; poly [ADP-ribose] polymerase 1 [EC:2.4.2.30]
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E XPC-HR23B-CETN2 complex
F 111600890 DNA repair protein complementing XP-C cells homolog isoform X1 K10838 XPC; xeroderma pigmentosum group C-complementing protein
F 111593709 UV excision repair protein RAD23 homolog B K10839 RAD23; UV excision repair protein RAD23
E Cul4-DDB2 complex
F 111604779 RING-box protein 1A K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
F 111601088 RING-box protein 1B K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
F 111603518 RING-box protein 1-like K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
F 111605125 RING-box protein 1-like K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
F 111600720 cullin-4A K10609 CUL4; cullin 4
F 111594632 DNA damage-binding protein 1 K10610 DDB1; DNA damage-binding protein 1
E NER4 complex
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase II complex
F 111605338 DNA-directed RNA polymerase II subunit RPB1 K03006 RPB1; DNA-directed RNA polymerase II subunit RPB1 [EC:2.7.7.6]
F 111593245 DNA-directed RNA polymerase II subunit RPB2 K03010 RPB2; DNA-directed RNA polymerase II subunit RPB2 [EC:2.7.7.6]
F 111600403 DNA-directed RNA polymerase II subunit RPB3 K03011 RPB3; DNA-directed RNA polymerase II subunit RPB3
F 111593196 DNA-directed RNA polymerases I, II, and III subunit RPABC1 K03013 RPABC1; DNA-directed RNA polymerases I, II, and III subunit RPABC1
F 111604932 DNA-directed RNA polymerases I, II, and III subunit RPABC2 K03014 RPABC2; DNA-directed RNA polymerases I, II, and III subunit RPABC2
F 111599766 DNA-directed RNA polymerase II subunit RPB7 K03015 RPB7; DNA-directed RNA polymerase II subunit RPB7
F 111600961 DNA-directed RNA polymerases I, II, and III subunit RPABC3 K03016 RPABC3; DNA-directed RNA polymerases I, II, and III subunit RPABC3
F 111602617 DNA-directed RNA polymerase II subunit RPB9 K03017 RPB9; DNA-directed RNA polymerase II subunit RPB9
F 111593682 DNA-directed RNA polymerases I, II, and III subunit RPABC5 K03007 RPABC5; DNA-directed RNA polymerases I, II, and III subunit RPABC5
F 111595203 DNA-directed RNA polymerase II subunit RPB11 K03008 RPB11; DNA-directed RNA polymerase II subunit RPB11
F 111602582 DNA-directed RNA polymerases I, II, and III subunit RPABC4 K03009 RPABC4; DNA-directed RNA polymerases I, II, and III subunit RPABC4
E Cul4-CSA complex
F 111604779 RING-box protein 1A K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
F 111601088 RING-box protein 1B K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
F 111603518 RING-box protein 1-like K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
F 111605125 RING-box protein 1-like K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
F 111600720 cullin-4A K10609 CUL4; cullin 4
F 111594632 DNA damage-binding protein 1 K10610 DDB1; DNA damage-binding protein 1
E Other TCR factor
F 111598600 transcription elongation factor 1 homolog K25829 ELOF1; transcription elongation factor 1
D TFIIH complex
E 111599771 general transcription and DNA repair factor IIH helicase subunit XPB K10843 ERCC3; DNA excision repair protein ERCC-3 [EC:5.6.2.4]
E 115483461 general transcription and DNA repair factor IIH helicase subunit XPB K10843 ERCC3; DNA excision repair protein ERCC-3 [EC:5.6.2.4]
E 111597091 general transcription and DNA repair factor IIH helicase subunit XPD isoform X1 K10844 ERCC2; DNA excision repair protein ERCC-2 [EC:5.6.2.3]
E 111600644 general transcription factor IIH subunit 1 K03141 TFIIH1; transcription initiation factor TFIIH subunit 1
E 111592865 general transcription factor IIH subunit 2 K03142 TFIIH2; transcription initiation factor TFIIH subunit 2
E 111599095 general transcription factor IIH subunit 3 K03143 TFIIH3; transcription initiation factor TFIIH subunit 3
E 111600271 general transcription factor IIH subunit 3-like K03143 TFIIH3; transcription initiation factor TFIIH subunit 3
E 111594369 general transcription factor IIH subunit 4 K03144 TFIIH4; transcription initiation factor TFIIH subunit 4
E 111603752 general transcription factor IIH subunit 5 K10845 TTDA; TFIIH basal transcription factor complex TTD-A subunit
E 111597262 cyclin-dependent kinase 7 K02202 CDK7; cyclin-dependent kinase 7 [EC:2.7.11.22 2.7.11.23]
E 111597445 cyclin-H K06634 CCNH; cyclin H
E 111604092 CDK-activating kinase assembly factor MAT1 K10842 MNAT1; CDK-activating kinase assembly factor MAT1
D RPA (replication factor A)
E 111605428 replication protein A 70 kDa DNA-binding subunit-like K07466 RFA1; replication factor A1
E 111594718 replication protein A 32 kDa subunit K10739 RFA2; replication factor A2
E 111602844 replication protein A 14 kDa subunit A K10740 RPA3; replication factor A3
D Other NER factors
E 111593534 DNA repair protein complementing XP-A cells homolog K10847 XPA; DNA-repair protein complementing XP-A cells
E 111598012 DNA excision repair protein ERCC-1 K10849 ERCC1; DNA excision repair protein ERCC-1
E 111599954 DNA repair endonuclease XPF K10848 ERCC4; DNA excision repair protein ERCC-4 [EC:3.1.-.-]
E 111603946 DNA repair protein complementing XP-G cells homolog K10846 ERCC5; DNA excision repair protein ERCC-5
E 111604949 MMS19 nucleotide excision repair protein homolog K15075 MET18; DNA repair/transcription protein MET18/MMS19
E 111601153 cullin-3-A isoform X1 K03869 CUL3; cullin 3
E 111596261 cullin-5 K10612 CUL5; cullin 5
E 111600070 elongin-C K03872 ELOC; elongin-C
E 111600634 elongin-B K03873 ELOB; elongin-B
E 111596598 transcription elongation factor B polypeptide 3 K15076 ELOA; elongin-A
E 111593304 protein lingerer isoform X1 K26545 UBAP2; ubiquitin-associated protein 2
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
E 111600377 DNA mismatch repair protein spellchecker 1 K08735 MSH2; DNA mismatch repair protein MSH2
E 111595124 probable DNA mismatch repair protein Msh6 K08737 MSH6; DNA mismatch repair protein MSH6
D MutL homologs
E 111595590 DNA mismatch repair protein Mlh1 K08734 MLH1; DNA mismatch repair protein MLH1
E 111597720 mismatch repair endonuclease PMS2 K10858 PMS2; DNA mismatch repair protein PMS2
D DNA polymerase delta complex
E 111598094 DNA polymerase delta catalytic subunit K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
E 111596855 DNA polymerase delta small subunit K02328 POLD2; DNA polymerase delta subunit 2
E 111602241 glutamic acid-rich protein K03504 POLD3; DNA polymerase delta subunit 3
D RPA (replication factor A)
E 111605428 replication protein A 70 kDa DNA-binding subunit-like K07466 RFA1; replication factor A1
E 111594718 replication protein A 32 kDa subunit K10739 RFA2; replication factor A2
E 111602844 replication protein A 14 kDa subunit A K10740 RPA3; replication factor A3
D RFC (replication factor C)
E 111595734 replication factor C subunit 1 K10754 RFC1; replication factor C subunit 1
E 111593328 replication factor C subunit 4 K10755 RFC2_4; replication factor C subunit 2/4
E 111596037 replication factor C subunit 2 K10755 RFC2_4; replication factor C subunit 2/4
E 111592628 replication factor C subunit 5 K10756 RFC3_5; replication factor C subunit 3/5
E 111592541 replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
D Other MMR factors
E 111594352 proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
E 111593598 proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
E 111595788 exonuclease 1 K10746 EXO1; exonuclease 1 [EC:3.1.-.-]
E 111595352 high mobility group protein DSP1 isoform X1 K10802 HMGB1; high mobility group protein B1
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D MRN(MRX) complex
E 111592587 double-strand break repair protein MRE11 K10865 MRE11; double-strand break repair protein MRE11
E 115482917 double-strand break repair protein MRE11-like K10865 MRE11; double-strand break repair protein MRE11
E 111605272 DNA repair protein RAD50 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
E 111598745 nibrin K10867 NBN; nibrin
D BRCA1-core complex
D BRCA1-A complex
D BRCA1-B complex
E 111600205 DNA topoisomerase 2-binding protein 1-A K10728 TOPBP1; topoisomerase (DNA) II binding protein 1
D BRCA1-C complex
E 111592587 double-strand break repair protein MRE11 K10865 MRE11; double-strand break repair protein MRE11
E 115482917 double-strand break repair protein MRE11-like K10865 MRE11; double-strand break repair protein MRE11
E 111605272 DNA repair protein RAD50 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
E 111598745 nibrin K10867 NBN; nibrin
D BRCA complex
E 111594462 DNA repair protein Rad51 homolog K04482 RAD51; DNA repair protein RAD51
D RecA family proteins
E 111594462 DNA repair protein Rad51 homolog K04482 RAD51; DNA repair protein RAD51
E 111595870 DNA repair protein RAD51 homolog 3 K10870 RAD51L2; RAD51-like protein 2
E 111602108 uncharacterized protein LOC111602108 K10871 RAD51L3; RAD51-like protein 3
E 111601500 DNA repair protein XRCC3 K10880 XRCC3; DNA-repair protein XRCC3
D Rad52 family proteins
D Rad54 family proteins
E 111603907 DNA repair and recombination protein RAD54-like K10875 RAD54L; DNA repair and recombination protein RAD54 and RAD54-like protein [EC:5.6.2.-]
D RecQ family DNA helicases
E 111596737 Werner syndrome ATP-dependent helicase-like K10900 WRN; werner syndrome ATP-dependent helicase [EC:5.6.2.4]
E 111596452 Bloom syndrome protein homolog K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 111598198 ATP-dependent DNA helicase Q4 K10730 RECQL4; ATP-dependent DNA helicase Q4 [EC:5.6.2.4]
E 111599826 ATP-dependent DNA helicase Q5 isoform X1 K10902 RECQL5; ATP-dependent DNA helicase Q5 [EC:5.6.2.4]
D Bloom's syndrome complex (BTR)
E 111596452 Bloom syndrome protein homolog K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 111594720 DNA topoisomerase 3-alpha isoform X1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 111605119 DNA topoisomerase 3-beta K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
D RPA (replication factor A)
E 111605428 replication protein A 70 kDa DNA-binding subunit-like K07466 RFA1; replication factor A1
E 111594718 replication protein A 32 kDa subunit K10739 RFA2; replication factor A2
E 111602844 replication protein A 14 kDa subunit A K10740 RPA3; replication factor A3
D Protein phosphatase 4
E 111593632 serine/threonine-protein phosphatase 4 catalytic subunit K15423 PPP4C; serine/threonine-protein phosphatase 4 catalytic subunit [EC:3.1.3.16]
E 111603113 serine/threonine-protein phosphatase 4 regulatory subunit 2 K15425 PPP4R2; serine/threonine-protein phosphatase 4 regulatory subunit 2
E 111594611 serine/threonine-protein phosphatase 4 regulatory subunit 3 isoform X1 K17491 SMEK; protein phosphatase 4 regulatory subunit 3
D AP-5 complex
D SMC5-SMC6 complex
E 111604323 structural maintenance of chromosomes protein 5 K22803 SMC5; structural maintenance of chromosomes protein 5
E 111597165 structural maintenance of chromosomes protein 6 K22804 SMC6; structural maintenance of chromosomes protein 6
E 111605034 non-structural maintenance of chromosomes element 1 homolog K22817 NSMCE1; non-structural maintenance of chromosomes element 1 [EC:2.3.2.27]
E 111601960 E3 SUMO-protein ligase NSE2 K22756 NSMCE2; E3 SUMO-protein ligase NSE2 [EC:2.3.2.-]
E 111603634 non-structural maintenance of chromosomes element 3 homolog K22823 NSMCE3; non-structural maintenance of chromosomes element 3
E 111592672 non-structural maintenance of chromosome element 4 isoform X1 K22825 NSMCE4; non-structural maintenance of chromosomes element 4
D Other HR factors
E 111604101 crossover junction endonuclease EME1 K10882 EME1; crossover junction endonuclease EME1 [EC:3.1.22.-]
E 111604578 exonuclease 3'-5' domain-containing protein 2 K20777 EXD2; exonuclease 3'-5' domain-containing protein 2 [EC:3.1.11.1]
E 111601948 crossover junction endonuclease MUS81 K08991 MUS81; crossover junction endonuclease MUS81 [EC:3.1.22.-]
E 111595933 probable 26S proteasome complex subunit sem1 K10881 SHFM1; 26 proteasome complex subunit DSS1
E 111604443 DNA repair protein SWI5 homolog K10991 SWI5; DNA repair protein Swi5/Sae3
E 111600859 structure-specific endonuclease subunit SLX1 homolog K15078 SLX1; structure-specific endonuclease subunit SLX1 [EC:3.6.1.-]
E 111601650 flap endonuclease GEN isoform X1 K15338 GEN1; holliday junction resolvase GEN1/YEN1 [EC:3.1.-.-]
E 111593287 spatacsin K19026 SPG11; spatacsin
E 111599418 zinc finger FYVE domain-containing protein 26 homolog K19027 ZFYVE26; zinc finger FYVE domain-containing protein 26
E 111603026 nuA4 complex subunit EAF3 homolog K11339 MORF4L1; mortality factor 4-like protein 1
E 111604523 deoxynucleoside triphosphate triphosphohydrolase SAMHD1 homolog isoform X1 K22544 SAMHD1; deoxynucleoside triphosphate triphosphohydrolase SAMHD1 [EC:3.1.5.-]
E 111596131 fidgetin-like protein 1 K22766 FIGNL1; fidgetin-like protein 1 [EC:5.6.2.-]
E 111598508 uncharacterized protein LOC111598508 K23112 BRAT1; BRCA1-associated ATM activator 1
E 111597535 putative uncharacterized protein DDB_G0294196 isoform X1 K23456 CFAP410; cilla- and flagella-associated protein
E 111596306 BRCA2-interacting transcriptional repressor EMSY K25790 EMSY; BRCA2-interacting transcriptional repressor EMSY
E 111604773 protein MMS22-like K26125 MMS22L; protein MMS22-like
E 111595086 tonsoku-like protein K09257 NFKBIL2; NF-kappa-B inhibitor-like protein 2
E 111592928 Werner Syndrome-like exonuclease K22807 WRNexo; werner syndrome-like exonuclease [EC:3.1.11.-]
C NHEJ (non-homologous end-joining)
D DNA-PK complex
E 111603407 ATP-dependent DNA helicase 2 subunit 1 K10884 XRCC6; ATP-dependent DNA helicase 2 subunit 1
E 111600302 X-ray repair cross-complementing protein 5 K10885 XRCC5; ATP-dependent DNA helicase 2 subunit 2
D MRX complex
E 111592587 double-strand break repair protein MRE11 K10865 MRE11; double-strand break repair protein MRE11
E 115482917 double-strand break repair protein MRE11-like K10865 MRE11; double-strand break repair protein MRE11
E 111605272 DNA repair protein RAD50 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
D DNA Ligase 4 complex
E 111603134 DNA ligase 4 K10777 LIG4; DNA ligase 4 [EC:6.5.1.1]
D X-family DNA polymerases
D Other NHEJ factors
E 111596201 aprataxin-like protein K10863 APTX; aprataxin [EC:3.6.1.70 3.6.1.71 3.6.1.72]
E 111596208 aprataxin-like protein K10863 APTX; aprataxin [EC:3.6.1.70 3.6.1.71 3.6.1.72]
E 111595926 aprataxin and PNK-like factor isoform X1 K13295 APLF; aprataxin and PNK-like factor [EC:3.1.-.-]
C FA (Fanconi anemia) pathway
D FA core complex
E 111594622 uncharacterized protein LOC111594622 K10606 FANCL; E3 ubiquitin-protein ligase FANCL [EC:2.3.2.27]
E 111593642 uncharacterized protein LOC111593642 isoform X1 K10896 FANCM; fanconi anemia group M protein
D FA core complex binding factors
D Bloom's syndrome complex (BTR)
E 111596452 Bloom syndrome protein homolog K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 111594720 DNA topoisomerase 3-alpha isoform X1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 111605119 DNA topoisomerase 3-beta K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
D FANCD2-I complex
E 111600748 Fanconi anemia group D2 protein K10891 FANCD2; fanconi anemia group D2 protein
E 115483777 LOW QUALITY PROTEIN: Fanconi anemia group D2 protein-like K10891 FANCD2; fanconi anemia group D2 protein
E 111594091 Fanconi anemia group I protein K10895 FANCI; fanconi anemia group I protein
D Downstream FA components
D Other FA pathway factors
E 111594462 DNA repair protein Rad51 homolog K04482 RAD51; DNA repair protein RAD51
E 111595870 DNA repair protein RAD51 homolog 3 K10870 RAD51L2; RAD51-like protein 2
E 111595229 ubiquitin carboxyl-terminal hydrolase 1 K11832 USP1; ubiquitin carboxyl-terminal hydrolase 1 [EC:3.4.19.12]
E 111605224 WD repeat-containing protein 48 homolog K15361 WDR48; WD repeat-containing protein 48
C Other DSBR factors
D Protein phosphatase 6
E 111601362 serine/threonine-protein phosphatase 6 catalytic subunit-like K15498 PPP6C; serine/threonine-protein phosphatase 6 catalytic subunit [EC:3.1.3.16]
E 111602048 serine/threonine-protein phosphatase 6 catalytic subunit K15498 PPP6C; serine/threonine-protein phosphatase 6 catalytic subunit [EC:3.1.3.16]
E 111600454 serine/threonine-protein phosphatase 6 regulatory subunit 3 K15501 PPP6R3; serine/threonine-protein phosphatase 6 regulatory subunit 3
D Ubiquitin ligases
E 111593624 probable E3 ubiquitin-protein ligase HERC2 K10595 HERC2; E3 ubiquitin-protein ligase HERC2 [EC:2.3.2.26]
D Others
E 111596299 telomerase Cajal body protein 1 homolog K23314 WRAP53; telomerase Cajal body protein 1
E 111601218 gastrulation defective protein 1 homolog K24752 WDR70; WD repeat-containing protein 70
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
D 111594910 DNA polymerase eta K03509 POLH; DNA polymerase eta [EC:2.7.7.7]
D 111605458 DNA polymerase iota K03510 POLI; DNA polymerase iota [EC:2.7.7.7]
D 111598682 DNA repair protein REV1 K03515 REV1; DNA repair protein REV1 [EC:2.7.7.-]
C B-family DNA polymerases
D 111593881 DNA polymerase zeta catalytic subunit K02350 REV3L; DNA polymerase zeta [EC:2.7.7.7]
C A-family DNA polymerase
C Rad6 epistasis group
D 111593620 ubiquitin-conjugating enzyme E2-17 kDa K10573 UBE2A; ubiquitin-conjugating enzyme E2 A [EC:2.3.2.23]
D 111601683 ubiquitin-conjugating enzyme E2 variant 2 K10704 UBE2V; ubiquitin-conjugating enzyme E2 variant
D 111601506 ubiquitin-conjugating enzyme E2 N K10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23]
D 111605014 ubiquitin-conjugating enzyme E2 N K10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23]
C Other TLS factors
D 111594352 proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
D 111593598 proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
D 111596764 sprT-like domain-containing protein Spartan K24051 SPRTN; SprT-like domain-contaning protein Spartan
D 111595953 uncharacterized protein LOC111595953 K26957 GCNA; germ cell nuclear acidic protein
B Check point factors
C Rad9-Hus1-Rad1 complex
D 111592265 cell cycle checkpoint control protein RAD9A isoform X1 K10994 RAD9A; cell cycle checkpoint control protein RAD9A [EC:3.1.11.2]
D 111595740 checkpoint protein HUS1 K10903 HUS1; HUS1 checkpoint protein
D 111596446 cell cycle checkpoint protein RAD1 K02830 HRAD1; cell cycle checkpoint protein [EC:3.1.11.2]
C HRAD17(Rad24)-RFC complex
D 111595683 cell cycle checkpoint protein RAD17 K06662 HRAD17; cell cycle checkpoint protein
D 111593328 replication factor C subunit 4 K10755 RFC2_4; replication factor C subunit 2/4
D 111596037 replication factor C subunit 2 K10755 RFC2_4; replication factor C subunit 2/4
D 111592628 replication factor C subunit 5 K10756 RFC3_5; replication factor C subunit 3/5
D 111592541 replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
C Rad17-Mec3-Ddc1 complex
D 111596446 cell cycle checkpoint protein RAD1 K02830 HRAD1; cell cycle checkpoint protein [EC:3.1.11.2]
C FPC (fork protection complex)
D 111594627 protein timeless homolog K10997 TIMELESS; replication fork protection complex subunit TIMELESS/Tof1/Swi1
D 115483332 protein timeless homolog K10997 TIMELESS; replication fork protection complex subunit TIMELESS/Tof1/Swi1
D 111595768 protein TIPIN homolog K10998 TIPIN; replication fork protection complex subunit TIPIN/Csm3/Swi3
D 111598683 claspin K25773 CLSPN; claspin
C Triple T complex
D 111602789 uncharacterized protein LOC111602789 K20403 TTI1; TELO2-interacting protein 1
C BAG6-UBL4A-GET4 complex
D 111593200 homeobox protein prospero isoform X1 K23390 BAG6; large proline-rich protein BAG6
D 115482742 homeobox protein prospero-like isoform X1 K23390 BAG6; large proline-rich protein BAG6
D 111601337 ubiquitin-like protein 4A K23388 UBL4; ubiquitin-like protein 4
D 111601983 Golgi to ER traffic protein 4 homolog K23387 GET4; golgi to ER traffic protein 4
C Other check point factors
D 111599446 serine/threonine-protein kinase ATR K06640 ATR; serine/threonine-protein kinase ATR [EC:2.7.11.1]
D 111593396 serine/threonine-protein kinase ATM K04728 ATM; serine-protein kinase ATM [EC:2.7.11.1]
D 111596373 serine/threonine-protein kinase grp isoform X1 K02216 CHEK1; serine/threonine-protein kinase CHEK1 [EC:2.7.11.1]
D 111600369 ovarian-specific serine/threonine-protein kinase Lok K06641 CHEK2; serine/threonine-protein kinase CHEK2 [EC:2.7.11.1]
D 111595240 M-phase inducer phosphatase K05866 CDC25B; M-phase inducer phosphatase 2 [EC:3.1.3.48]
D 111593731 14-3-3 protein zeta isoform X1 K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
D 111595773 14-3-3 protein epsilon K06630 YWHAE; 14-3-3 protein epsilon
D 111605015 wee1-like protein kinase K06632 WEE1; wee1-like protein kinase [EC:2.7.11.1]
D 111593496 period circadian protein isoform X2 K02633 PER2; period circadian protein 2
D 111601736 uncharacterized protein LOC111601736 isoform X1 K20780 MDC1; mediator of DNA damage checkpoint protein 1
D 111595948 plastin-2 isoform X1 K17336 PLS3; plastin-3
D 111604898 protein downstream neighbor of son homolog K22422 DONSON; protein downstream neighbor of Son
D 111602543 KN motif and ankyrin repeat domain-containing protein 2 isoform X1 K22808 KANK; KN motif and ankyrin repeat domain-containing protein
D 111602851 vacuolar protein sorting-associated protein 4B K12196 VPS4; vacuolar protein-sorting-associated protein 4
D 111595970 abscission/NoCut checkpoint regulator K24778 ZFYVE19; abscission/NoCut checkpoint regulator
D 111604197 replication stress response regulator SDE2 K25059 SDE2; replication stress response regulator SDE2
B Other factors with a suspected DNA repair function
C DNA polymerases
D 111598083 DNA polymerase theta K02349 POLQ; DNA polymerase theta [EC:2.7.7.7]
D 111592993 myb-binding protein 1A K02331 POL5; DNA polymerase phi [EC:2.7.7.7]
C Nucleases
D 111603965 uncharacterized protein LOC111603965 K10790 TREX1; three prime repair exonuclease 1 [EC:3.1.11.2]
D 111603587 DNA cross-link repair 1A protein K15340 DCLRE1A; DNA cross-link repair 1A protein
D 111602310 uncharacterized protein LOC111602310 K21411 ANKLE1; ankyrin repeat and LEM domain-containing protein 1
D 111602591 ankyrin repeat and LEM domain-containing protein 1 K21411 ANKLE1; ankyrin repeat and LEM domain-containing protein 1
C Helicases
D 111601689 helicase POLQ-like K19178 HELQ; POLQ-like helicase [EC:5.6.2.4]
C PSO4 complex
D 111602364 pre-mRNA-processing factor 19 K10599 PRPF19; pre-mRNA-processing factor 19 [EC:2.3.2.27]
D 111601039 cell division cycle 5-like protein K12860 CDC5L; pre-mRNA-splicing factor CDC5/CEF1
D 111603301 pre-mRNA-splicing factor SPF27 K12861 BCAS2; pre-mRNA-splicing factor SPF27
D 111596801 pleiotropic regulator 1 K12862 PLRG1; pleiotropic regulator 1
C Modulation of nucleotide pools
D 111604557 8-oxo-dGDP phosphatase NUDT18 K17817 NUDT18; 8-oxo-dGDP phosphatase [EC:3.6.1.58]
D 111596128 deoxyuridine 5'-triphosphate nucleotidohydrolase K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 111597781 ribonucleoside-diphosphate reductase large subunit K10807 RRM1; ribonucleoside-diphosphate reductase subunit M1 [EC:1.17.4.1]
D 111603114 ribonucleoside-diphosphate reductase subunit M2 K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]
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AProkaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D 111599908 deoxyribodipyrimidine photo-lyase-like isoform X1 K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]
C BER (base exicision repair)
D DNA glycosylases
E 111601474 single-strand selective monofunctional uracil-DNA glycosylase K10800 SMUG1; single-strand selective monofunctional uracil DNA glycosylase [EC:3.2.2.-]
E 111599003 endonuclease III-like protein 1 K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
D RecJ
D DNA ligase
D DNA polymerase I
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase complex (RNAP)
E TRCF (transcription-repair coupling factor)
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
D Molecular matchmaker
D Strand discrimination factor
D DNA exonucleases
D DNA polymerase III holoenzyme
D DNA ligase
D Other MMR factors
E 111604634 single-stranded DNA-binding protein, mitochondrial K03111 ssb; single-strand DNA-binding protein
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D RecBC pathway proteins
D RecFOR pathway proteins
D AddAB pathway proteins
D Other HR factor
D Archaeal homologous recombinant proteins
C NHEJ (non-homologous end-joining)
D Two-component NHEJ DNA repair complex
D SHIIR (short-homology-independent illegitimate recombination)
E Facilitator
E Supressor
D SHDIR (short-homology-dependent illegitimate recombination)
E RecET pathway
E Facilitator
E Supressor
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
C Other SOS response factors
D 111604634 single-stranded DNA-binding protein, mitochondrial K03111 ssb; single-strand DNA-binding protein
B Other factors with a suspected DNA repair function
C DNA polymerase
C DNA helicases
C Modulation of nucleotide pools
D 111596128 deoxyuridine 5'-triphosphate nucleotidohydrolase K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
C Others
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: March 29, 2024