+F Repair protein KO
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DNA Repair and Recombination Proteins - Daphnia magna (water flea)
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AEukaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D 116915333 activating signal cointegrator 1 complex subunit 3 K18663 ASCC3; activating signal cointegrator complex subunit 3 [EC:5.6.2.4]
D 116919804 deoxyribodipyrimidine photo-lyase isoform X1 K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]
C BER (base exicision repair)
D DNA glycosylases
E 116928056 uracil-DNA glycosylase K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E 116922059 cyclin-A1 K10861 UDG2; uracil-DNA glycosylase 2 [EC:3.2.2.-]
E 116920206 uncharacterized protein LOC116920206 K20813 TDG; thymine-DNA glycosylase [EC:3.2.2.29]
E 116921963 DNA-3-methyladenine glycosylase K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]
E 116922578 single-strand selective monofunctional uracil DNA glycosylase K10800 SMUG1; single-strand selective monofunctional uracil DNA glycosylase [EC:3.2.2.-]
E 116933040 adenine DNA glycosylase isoform X1 K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
E 123469484 adenine DNA glycosylase-like isoform X1 K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
E 116932316 N-glycosylase/DNA lyase isoform X3 K03660 OGG1; N-glycosylase/DNA lyase [EC:3.2.2.- 4.2.99.18]
E 116924697 endonuclease 8-like 1 isoform X3 K10567 NEIL1; endonuclease VIII-like 1 [EC:3.2.2.- 4.2.99.18]
E 116926131 endonuclease III-like protein 1 isoform X1 K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
E 116919538 DNA-(apurinic or apyrimidinic site) endonuclease K10771 APEX1; AP endonuclease 1 [EC:3.1.11.2]
E 116927440 DNA-(apurinic or apyrimidinic site) endonuclease 2 isoform X1 K10772 APEX2; AP endonuclease 2 [EC:3.1.11.2]
D Long Patch-BER factors
E DNA polymerase delta complex
F 116925863 DNA polymerase delta catalytic subunit K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
F 116919638 DNA polymerase delta subunit 2 K02328 POLD2; DNA polymerase delta subunit 2
F 116932025 DNA polymerase delta subunit 3 K03504 POLD3; DNA polymerase delta subunit 3
E DNA polymerase epsilon complex
F 116921987 LOW QUALITY PROTEIN: DNA polymerase epsilon catalytic subunit A K02324 POLE; DNA polymerase epsilon subunit 1 [EC:2.7.7.7]
F 116931637 LOW QUALITY PROTEIN: DNA polymerase epsilon subunit 2 K02325 POLE2; DNA polymerase epsilon subunit 2 [EC:2.7.7.7]
F 116925848 DNA polymerase epsilon subunit 4 K03506 POLE4; DNA polymerase epsilon subunit 4 [EC:2.7.7.7]
E 116924898 proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
E 116932115 flap endonuclease 1 K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
E 116917654 DNA ligase 1 isoform X1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
D Short Patch-BER factors
E 116930263 DNA repair protein XRCC1 isoform X1 K10803 XRCC1; DNA-repair protein XRCC1
D Other BER factors
E 116924222 probable tyrosyl-DNA phosphodiesterase K10862 TDP1; tyrosyl-DNA phosphodiesterase 1 [EC:3.1.4.-]
E 116917474 aprataxin isoform X1 K10863 APTX; aprataxin [EC:3.6.1.70 3.6.1.71 3.6.1.72]
E 116926574 aprataxin and PNK-like factor isoform X1 K13295 APLF; aprataxin and PNK-like factor [EC:3.1.-.-]
E 116926489 LOW QUALITY PROTEIN: uncharacterized protein F21D5.5-like K08073 PNKP; bifunctional polynucleotide phosphatase/kinase [EC:3.1.3.32 2.7.1.78]
E 116924228 high mobility group protein DSP1 K10802 HMGB1; high mobility group protein B1
E 116931275 high mobility group protein DSP1 K10802 HMGB1; high mobility group protein B1
E 116923405 poly [ADP-ribose] polymerase 1 K24070 PARP1; poly [ADP-ribose] polymerase 1 [EC:2.4.2.30]
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E XPC-HR23B-CETN2 complex
F 116919225 UV excision repair protein RAD23 homolog B K10839 RAD23; UV excision repair protein RAD23
F 116925619 caltractin K10840 CETN2; centrin-2
E Cul4-DDB2 complex
F 116925355 RING-box protein 1A K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
F 123466277 cullin-4A-like K10609 CUL4; cullin 4
F 116925210 DNA damage-binding protein 1 isoform X1 K10610 DDB1; DNA damage-binding protein 1
F 123473641 DNA damage-binding protein 1-like isoform X1 K10610 DDB1; DNA damage-binding protein 1
E NER4 complex
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase II complex
F 116926715 DNA-directed RNA polymerase II subunit RPB1-like K03006 RPB1; DNA-directed RNA polymerase II subunit RPB1 [EC:2.7.7.6]
F 116915353 DNA-directed RNA polymerase II subunit RPB2 K03010 RPB2; DNA-directed RNA polymerase II subunit RPB2 [EC:2.7.7.6]
F 116922980 DNA-directed RNA polymerase II subunit RPB3 K03011 RPB3; DNA-directed RNA polymerase II subunit RPB3
F 116930380 DNA-directed RNA polymerases I, II, and III subunit RPABC1 K03013 RPABC1; DNA-directed RNA polymerases I, II, and III subunit RPABC1
F 116927783 DNA-directed RNA polymerases I, II, and III subunit RPABC2 K03014 RPABC2; DNA-directed RNA polymerases I, II, and III subunit RPABC2
F 116916165 DNA-directed RNA polymerase II subunit RPB7 isoform X1 K03015 RPB7; DNA-directed RNA polymerase II subunit RPB7
F 123470088 DNA-directed RNA polymerase II subunit RPB7 K03015 RPB7; DNA-directed RNA polymerase II subunit RPB7
F 116926588 DNA-directed RNA polymerases I, II, and III subunit RPABC3 isoform X2 K03016 RPABC3; DNA-directed RNA polymerases I, II, and III subunit RPABC3
F 116918474 DNA-directed RNA polymerase II subunit RPB9 K03017 RPB9; DNA-directed RNA polymerase II subunit RPB9
F 116920881 DNA-directed RNA polymerase II subunit RPB11 K03008 RPB11; DNA-directed RNA polymerase II subunit RPB11
F 116929832 DNA-directed RNA polymerases I, II, and III subunit RPABC4 K03009 RPABC4; DNA-directed RNA polymerases I, II, and III subunit RPABC4
E Cul4-CSA complex
F 116925355 RING-box protein 1A K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
F 123466277 cullin-4A-like K10609 CUL4; cullin 4
F 116925210 DNA damage-binding protein 1 isoform X1 K10610 DDB1; DNA damage-binding protein 1
F 123473641 DNA damage-binding protein 1-like isoform X1 K10610 DDB1; DNA damage-binding protein 1
F 116919073 DNA excision repair protein ERCC-8 K10570 ERCC8; DNA excision repair protein ERCC-8
E Other TCR factor
F 116936625 UV-stimulated scaffold protein A isoform X1 K23720 UVSSA; UV-stimulated scaffold protein A
F 116928324 transcription elongation factor 1 homolog K25829 ELOF1; transcription elongation factor 1
D TFIIH complex
E 116916143 general transcription and DNA repair factor IIH helicase subunit XPB K10843 ERCC3; DNA excision repair protein ERCC-3 [EC:5.6.2.4]
E 116917236 general transcription and DNA repair factor IIH helicase subunit XPD K10844 ERCC2; DNA excision repair protein ERCC-2 [EC:5.6.2.3]
E 116932024 general transcription factor IIH subunit 1 K03141 TFIIH1; transcription initiation factor TFIIH subunit 1
E 116929262 general transcription factor IIH subunit 2 K03142 TFIIH2; transcription initiation factor TFIIH subunit 2
E 116928987 general transcription factor IIH subunit 3 K03143 TFIIH3; transcription initiation factor TFIIH subunit 3
E 116931527 cyclin-H K06634 CCNH; cyclin H
E 116924321 CDK-activating kinase assembly factor MAT1 K10842 MNAT1; CDK-activating kinase assembly factor MAT1
D RPA (replication factor A)
E 116916233 replication protein A 70 kDa DNA-binding subunit K07466 RFA1; replication factor A1
E 116915930 replication protein A 32 kDa subunit K10739 RFA2; replication factor A2
E 116924368 uncharacterized protein LOC116924368 K10740 RPA3; replication factor A3
D Other NER factors
E 116924948 DNA repair protein complementing XP-A cells homolog K10847 XPA; DNA-repair protein complementing XP-A cells
E 116922273 DNA excision repair protein ERCC-1 K10849 ERCC1; DNA excision repair protein ERCC-1
E 116925688 DNA repair endonuclease XPF K10848 ERCC4; DNA excision repair protein ERCC-4 [EC:3.1.-.-]
E 116918325 DNA excision repair protein ERCC-5 K10846 ERCC5; DNA excision repair protein ERCC-5
E 116917654 DNA ligase 1 isoform X1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
E 116921735 MMS19 nucleotide excision repair protein homolog K15075 MET18; DNA repair/transcription protein MET18/MMS19
E 116921676 cullin-3-A K03869 CUL3; cullin 3
E 116929428 cullin-5 K10612 CUL5; cullin 5
E 116930199 elongin-C isoform X1 K03872 ELOC; elongin-C
E 116920825 elongin-B K03873 ELOB; elongin-B
E 116930107 transcription elongation factor B polypeptide 3 K15076 ELOA; elongin-A
E 116931036 protein lingerer K26545 UBAP2; ubiquitin-associated protein 2
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
E 116921064 DNA mismatch repair protein Msh2 K08735 MSH2; DNA mismatch repair protein MSH2
E 116932357 DNA mismatch repair protein Msh3 isoform X1 K08736 MSH3; DNA mismatch repair protein MSH3
E 116936464 DNA mismatch repair protein Msh6 K08737 MSH6; DNA mismatch repair protein MSH6
D MutL homologs
E 116922690 PMS1 protein homolog 1 isoform X1 K10864 PMS1; DNA mismatch repair protein PMS1
E 116936649 LOW QUALITY PROTEIN: DNA mismatch repair protein Mlh1 K08734 MLH1; DNA mismatch repair protein MLH1
E 116926496 mismatch repair endonuclease PMS2 K10858 PMS2; DNA mismatch repair protein PMS2
E 116929688 DNA mismatch repair protein Mlh3 isoform X1 K08739 MLH3; DNA mismatch repair protein MLH3
D DNA polymerase delta complex
E 116925863 DNA polymerase delta catalytic subunit K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
E 116919638 DNA polymerase delta subunit 2 K02328 POLD2; DNA polymerase delta subunit 2
E 116932025 DNA polymerase delta subunit 3 K03504 POLD3; DNA polymerase delta subunit 3
D RPA (replication factor A)
E 116916233 replication protein A 70 kDa DNA-binding subunit K07466 RFA1; replication factor A1
E 116915930 replication protein A 32 kDa subunit K10739 RFA2; replication factor A2
E 116924368 uncharacterized protein LOC116924368 K10740 RPA3; replication factor A3
D RFC (replication factor C)
E 116915637 LOW QUALITY PROTEIN: replication factor C subunit 1 K10754 RFC1; replication factor C subunit 1
E 116933118 replication factor C subunit 4 K10755 RFC2_4; replication factor C subunit 2/4
E 116915837 replication factor C subunit 2 K10755 RFC2_4; replication factor C subunit 2/4
E 116924347 replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
E 116924752 replication factor C subunit 5 K10756 RFC3_5; replication factor C subunit 3/5
D Other MMR factors
E 116924898 proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
E 116918926 exonuclease 1 K10746 EXO1; exonuclease 1 [EC:3.1.-.-]
E 116924228 high mobility group protein DSP1 K10802 HMGB1; high mobility group protein B1
E 116931275 high mobility group protein DSP1 K10802 HMGB1; high mobility group protein B1
E 116917654 DNA ligase 1 isoform X1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
E 116922846 WD repeat-containing protein 76 K24755 WDR76; WD repeat-containing protein 76
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D MRN(MRX) complex
E 116924671 double-strand break repair protein MRE11 K10865 MRE11; double-strand break repair protein MRE11
E 116927456 LOW QUALITY PROTEIN: DNA repair protein RAD50 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
E 116922839 nibrin K10867 NBN; nibrin
D BRCA1-core complex
E 116920843 breast cancer type 1 susceptibility protein homolog isoform X1 K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 123470965 breast cancer type 1 susceptibility protein homolog isoform X1 K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 116918974 BRCA1-associated RING domain protein 1 isoform X1 K10683 BARD1; BRCA1-associated RING domain protein 1
D BRCA1-A complex
E 116920843 breast cancer type 1 susceptibility protein homolog isoform X1 K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 123470965 breast cancer type 1 susceptibility protein homolog isoform X1 K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 116921872 BRISC complex subunit FAM175B K20774 FAM175A; BRCA1-A complex subunit Abraxas
E 116931899 BRISC and BRCA1-A complex member 2 K12173 BRE; BRCA1-A complex subunit BRE
E 123475238 lys-63-specific deubiquitinase BRCC36-like K11864 BRCC3; BRCA1/BRCA2-containing complex subunit 3 [EC:3.4.19.-]
E 123475438 lys-63-specific deubiquitinase BRCC36-like isoform X1 K11864 BRCC3; BRCA1/BRCA2-containing complex subunit 3 [EC:3.4.19.-]
E 116933427 lys-63-specific deubiquitinase BRCC36-like K11864 BRCC3; BRCA1/BRCA2-containing complex subunit 3 [EC:3.4.19.-]
D BRCA1-B complex
E 116920843 breast cancer type 1 susceptibility protein homolog isoform X1 K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 123470965 breast cancer type 1 susceptibility protein homolog isoform X1 K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 116931252 Fanconi anemia group J protein isoform X1 K15362 BRIP1; fanconi anemia group J protein [EC:5.6.2.3]
E 116917952 DNA topoisomerase 2-binding protein 1 K10728 TOPBP1; topoisomerase (DNA) II binding protein 1
E 116918549 DNA topoisomerase 2-binding protein 1 isoform X2 K10728 TOPBP1; topoisomerase (DNA) II binding protein 1
D BRCA1-C complex
E 116920843 breast cancer type 1 susceptibility protein homolog isoform X1 K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 123470965 breast cancer type 1 susceptibility protein homolog isoform X1 K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 116924671 double-strand break repair protein MRE11 K10865 MRE11; double-strand break repair protein MRE11
E 116927456 LOW QUALITY PROTEIN: DNA repair protein RAD50 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
E 116922839 nibrin K10867 NBN; nibrin
D BRCA complex
E 116920843 breast cancer type 1 susceptibility protein homolog isoform X1 K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 123470965 breast cancer type 1 susceptibility protein homolog isoform X1 K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 116929007 LOW QUALITY PROTEIN: breast cancer type 2 susceptibility protein homolog K08775 BRCA2; breast cancer 2 susceptibility protein
E 116921191 DNA repair protein RAD51 homolog A K04482 RAD51; DNA repair protein RAD51
D RecA family proteins
E 116921191 DNA repair protein RAD51 homolog A K04482 RAD51; DNA repair protein RAD51
E 123475432 DNA repair protein RAD51 homolog 2-like isoform X1 K10869 RAD51L1; RAD51-like protein 1
E 116925583 DNA repair protein RAD51 homolog 3 K10870 RAD51L2; RAD51-like protein 2
E 116918003 DNA repair protein RAD51 homolog 4 K10871 RAD51L3; RAD51-like protein 3
E 116935471 DNA repair protein XRCC2 K10879 XRCC2; DNA-repair protein XRCC2
D Rad52 family proteins
E 116928876 DNA repair protein RAD52 homolog isoform X1 K10873 RAD52; DNA repair and recombination protein RAD52
D Rad54 family proteins
E 116917237 LOW QUALITY PROTEIN: DNA repair and recombination protein RAD54-like K10875 RAD54L; DNA repair and recombination protein RAD54 and RAD54-like protein [EC:5.6.2.-]
E 116933520 helicase ARIP4 K10876 RAD54L2; RAD54-like protein 2 [EC:5.6.2.-]
E 123469823 mucin-17-like K10876 RAD54L2; RAD54-like protein 2 [EC:5.6.2.-]
E 116920144 DNA repair and recombination protein RAD54B isoform X1 K10877 RAD54B; DNA repair and recombination protein RAD54B [EC:5.6.2.-]
D RecQ family DNA helicases
E 116926285 ATP-dependent DNA helicase Q1 K10899 RECQL; ATP-dependent DNA helicase Q1 [EC:5.6.2.4]
E 116935840 Bloom syndrome protein homolog isoform X1 K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 116932303 LOW QUALITY PROTEIN: ATP-dependent DNA helicase Q4 K10730 RECQL4; ATP-dependent DNA helicase Q4 [EC:5.6.2.4]
E 116926391 ATP-dependent DNA helicase Q5 K10902 RECQL5; ATP-dependent DNA helicase Q5 [EC:5.6.2.4]
D Bloom's syndrome complex (BTR)
E 116935840 Bloom syndrome protein homolog isoform X1 K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 116917270 DNA topoisomerase 3-beta-1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 116917082 LOW QUALITY PROTEIN: DNA topoisomerase 3-alpha K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 116934095 recQ-mediated genome instability protein 1 K10990 RMI1; RecQ-mediated genome instability protein 1
D RPA (replication factor A)
E 116916233 replication protein A 70 kDa DNA-binding subunit K07466 RFA1; replication factor A1
E 116915930 replication protein A 32 kDa subunit K10739 RFA2; replication factor A2
E 116924368 uncharacterized protein LOC116924368 K10740 RPA3; replication factor A3
D Protein phosphatase 4
E 116932841 serine/threonine-protein phosphatase 4 catalytic subunit K15423 PPP4C; serine/threonine-protein phosphatase 4 catalytic subunit [EC:3.1.3.16]
E 116916636 serine/threonine-protein phosphatase 4 regulatory subunit 1 isoform X1 K15424 PPP4R1; serine/threonine-protein phosphatase 4 regulatory subunit 1
E 116926029 serine/threonine-protein phosphatase 4 regulatory subunit 2 K15425 PPP4R2; serine/threonine-protein phosphatase 4 regulatory subunit 2
E 116925473 LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 4 regulatory subunit 3 K17491 SMEK; protein phosphatase 4 regulatory subunit 3
E 116918469 serine/threonine-protein phosphatase 4 regulatory subunit 4 isoform X1 K15426 PPP4R4; serine/threonine-protein phosphatase 4 regulatory subunit 4
D AP-5 complex
E 116919203 uncharacterized protein LOC116919203 isoform X1 K19023 AP5M1; AP-5 complex subunit mu-1
D SMC5-SMC6 complex
E 116915359 structural maintenance of chromosomes protein 5 K22803 SMC5; structural maintenance of chromosomes protein 5
E 116923393 LOW QUALITY PROTEIN: structural maintenance of chromosomes protein 6 K22804 SMC6; structural maintenance of chromosomes protein 6
E 116922570 LOW QUALITY PROTEIN: structural maintenance of chromosomes protein 6-like K22804 SMC6; structural maintenance of chromosomes protein 6
E 116932618 non-structural maintenance of chromosomes element 1 homolog K22817 NSMCE1; non-structural maintenance of chromosomes element 1 [EC:2.3.2.27]
E 116930365 E3 SUMO-protein ligase NSE2 K22756 NSMCE2; E3 SUMO-protein ligase NSE2 [EC:2.3.2.-]
E 116924963 EP300-interacting inhibitor of differentiation 3 K22825 NSMCE4; non-structural maintenance of chromosomes element 4
D Other HR factors
E 116928052 crossover junction endonuclease EME1 isoform X1 K10882 EME1; crossover junction endonuclease EME1 [EC:3.1.22.-]
E 116927368 exonuclease 3'-5' domain-containing protein 2 K20777 EXD2; exonuclease 3'-5' domain-containing protein 2 [EC:3.1.11.1]
E 116929794 crossover junction endonuclease MUS81 isoform X1 K08991 MUS81; crossover junction endonuclease MUS81 [EC:3.1.22.-]
E 123475724 26S proteasome complex subunit SEM1-like K10881 SHFM1; 26 proteasome complex subunit DSS1
E 116917471 structure-specific endonuclease subunit slx1 K15078 SLX1; structure-specific endonuclease subunit SLX1 [EC:3.6.1.-]
E 116930953 uncharacterized protein LOC116930953 K10484 BTBD12; structure-specific endonuclease subunit SLX4 (BTB/POZ domain-containing protein 12)
E 116916448 flap endonuclease GEN homolog 1 K15338 GEN1; holliday junction resolvase GEN1/YEN1 [EC:3.1.-.-]
E 116932847 uncharacterized protein LOC116932847 K19027 ZFYVE26; zinc finger FYVE domain-containing protein 26
E 116918565 mortality factor 4-like protein 1 K11339 MORF4L1; mortality factor 4-like protein 1
E 116920812 fidgetin-like protein 1 isoform X1 K22766 FIGNL1; fidgetin-like protein 1 [EC:5.6.2.-]
E 116926434 BRCA1-associated ATM activator 1 isoform X1 K23112 BRAT1; BRCA1-associated ATM activator 1
E 116927628 uncharacterized protein LOC116927628 K23456 CFAP410; cilla- and flagella-associated protein
E 116915502 zinc finger SWIM domain-containing protein 7 isoform X2 K25770 ZSWIM7; zinc finger SWIM domain-containing protein 7
E 116921176 BRCA2-interacting transcriptional repressor EMSY isoform X1 K25790 EMSY; BRCA2-interacting transcriptional repressor EMSY
E 116915358 protein MMS22-like K26125 MMS22L; protein MMS22-like
E 116921471 tonsoku-like protein isoform X1 K09257 NFKBIL2; NF-kappa-B inhibitor-like protein 2
C NHEJ (non-homologous end-joining)
D DNA-PK complex
E 116925756 X-ray repair cross-complementing protein 6 isoform X1 K10884 XRCC6; ATP-dependent DNA helicase 2 subunit 1
E 116926839 X-ray repair cross-complementing protein 5 K10885 XRCC5; ATP-dependent DNA helicase 2 subunit 2
E 116920680 DNA-dependent protein kinase catalytic subunit K06642 PRKDC; DNA-dependent protein kinase catalytic subunit [EC:2.7.11.1]
D MRX complex
E 116924671 double-strand break repair protein MRE11 K10865 MRE11; double-strand break repair protein MRE11
E 116927456 LOW QUALITY PROTEIN: DNA repair protein RAD50 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
D DNA Ligase 4 complex
E 116927708 DNA ligase 4 isoform X1 K10777 LIG4; DNA ligase 4 [EC:6.5.1.1]
E 116924473 uncharacterized protein LOC116924473 K10886 XRCC4; DNA-repair protein XRCC4
E 116926341 LOW QUALITY PROTEIN: non-homologous end-joining factor 1 K10980 NHEJ1; non-homologous end-joining factor 1
D X-family DNA polymerases
E 116921683 DNA nucleotidylexotransferase K00977 DNTT; DNA nucleotidylexotransferase [EC:2.7.7.31]
D Other NHEJ factors
E 116917474 aprataxin isoform X1 K10863 APTX; aprataxin [EC:3.6.1.70 3.6.1.71 3.6.1.72]
E 116926574 aprataxin and PNK-like factor isoform X1 K13295 APLF; aprataxin and PNK-like factor [EC:3.1.-.-]
E 116918979 protein artemis isoform X1 K10887 DCLRE1C; DNA cross-link repair 1C protein [EC:3.1.-.-]
E 116917620 tyrosyl-DNA phosphodiesterase 2 isoform X1 K19619 TDP2; tyrosyl-DNA phosphodiesterase 2 [EC:3.1.4.-]
C FA (Fanconi anemia) pathway
D FA core complex
E 116931983 uncharacterized protein LOC116931983 K10888 FANCA; fanconi anemia group A protein
E 116931646 uncharacterized protein LOC116931646 isoform X1 K10889 FANCB; fanconi anemia group B protein
E 116920682 E3 ubiquitin-protein ligase FANCL K10606 FANCL; E3 ubiquitin-protein ligase FANCL [EC:2.3.2.27]
E 116928685 Fanconi anemia group M protein homolog K10896 FANCM; fanconi anemia group M protein
E 116916525 Fanconi anemia core complex-associated protein 24 K10898 FAAP24; fanconi anemia-associated protein
D FA core complex binding factors
E 116930824 enhancer of split m7 protein K06054 HES1; hairy and enhancer of split 1
E 116924298 protein hairy K06054 HES1; hairy and enhancer of split 1
E 116930666 centromere protein S isoform X1 K11511 APITD1; centromere protein S
E 116915762 centromere protein X K15360 STRA13; centromere protein X
E 116917299 ubiquitin-conjugating enzyme E2 T K13960 UBE2T; ubiquitin-conjugating enzyme E2 T [EC:2.3.2.23]
D Bloom's syndrome complex (BTR)
E 116935840 Bloom syndrome protein homolog isoform X1 K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 116917270 DNA topoisomerase 3-beta-1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 116917082 LOW QUALITY PROTEIN: DNA topoisomerase 3-alpha K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 116934095 recQ-mediated genome instability protein 1 K10990 RMI1; RecQ-mediated genome instability protein 1
D FANCD2-I complex
E 116919984 LOW QUALITY PROTEIN: Fanconi anemia group D2 protein K10891 FANCD2; fanconi anemia group D2 protein
E 116918829 Fanconi anemia group I protein isoform X1 K10895 FANCI; fanconi anemia group I protein
D Downstream FA components
E 116920843 breast cancer type 1 susceptibility protein homolog isoform X1 K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 123470965 breast cancer type 1 susceptibility protein homolog isoform X1 K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 116929007 LOW QUALITY PROTEIN: breast cancer type 2 susceptibility protein homolog K08775 BRCA2; breast cancer 2 susceptibility protein
E 116931252 Fanconi anemia group J protein isoform X1 K15362 BRIP1; fanconi anemia group J protein [EC:5.6.2.3]
D Other FA pathway factors
E 116924890 LOW QUALITY PROTEIN: fanconi-associated nuclease 1 K15363 FAN1; fanconi-associated nuclease 1 [EC:3.1.21.- 3.1.4.1]
E 116921191 DNA repair protein RAD51 homolog A K04482 RAD51; DNA repair protein RAD51
E 116925583 DNA repair protein RAD51 homolog 3 K10870 RAD51L2; RAD51-like protein 2
E 116924981 ubiquitin carboxyl-terminal hydrolase 1 K11832 USP1; ubiquitin carboxyl-terminal hydrolase 1 [EC:3.4.19.12]
E 116929379 WD repeat-containing protein 48 isoform X1 K15361 WDR48; WD repeat-containing protein 48
C Other DSBR factors
D Protein phosphatase 6
E 116925881 serine/threonine-protein phosphatase 6 catalytic subunit K15498 PPP6C; serine/threonine-protein phosphatase 6 catalytic subunit [EC:3.1.3.16]
E 116924230 serine/threonine-protein phosphatase 6 regulatory subunit 2-like isoform X1 K15500 PPP6R2; serine/threonine-protein phosphatase 6 regulatory subunit 2
E 116935619 serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A isoform X1 K15502 ANKRD28; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A
D Ubiquitin ligases
E 116925057 E3 ubiquitin-protein ligase rnf8-A K10667 RNF8; E3 ubiquitin-protein ligase RNF8 [EC:2.3.2.27]
E 116916164 LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase RNF8 K10667 RNF8; E3 ubiquitin-protein ligase RNF8 [EC:2.3.2.27]
E 123467575 LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase rnf8-B-like K10667 RNF8; E3 ubiquitin-protein ligase RNF8 [EC:2.3.2.27]
E 123471552 E3 ubiquitin-protein ligase RNF8-like isoform X1 K10667 RNF8; E3 ubiquitin-protein ligase RNF8 [EC:2.3.2.27]
E 116915859 E3 ubiquitin-protein ligase rnf168 K20779 RNF168; E3 ubiquitin-protein ligase RNF168 [EC:2.3.2.31]
E 116923329 LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase HERC2 K10595 HERC2; E3 ubiquitin-protein ligase HERC2 [EC:2.3.2.26]
D Others
E 116921249 telomerase Cajal body protein 1 K23314 WRAP53; telomerase Cajal body protein 1
E 116927439 WD repeat-containing protein 70 K24752 WDR70; WD repeat-containing protein 70
E 116922846 WD repeat-containing protein 76 K24755 WDR76; WD repeat-containing protein 76
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
D 116924903 DNA polymerase eta K03509 POLH; DNA polymerase eta [EC:2.7.7.7]
D 116925565 DNA polymerase iota K03510 POLI; DNA polymerase iota [EC:2.7.7.7]
D 116926045 DNA polymerase kappa K03511 POLK; DNA polymerase kappa [EC:2.7.7.7]
D 116935947 DNA repair protein REV1 isoform X1 K03515 REV1; DNA repair protein REV1 [EC:2.7.7.-]
D 123466302 LOW QUALITY PROTEIN: DNA repair protein REV1-like K03515 REV1; DNA repair protein REV1 [EC:2.7.7.-]
D 123472496 LOW QUALITY PROTEIN: DNA repair protein REV1-like K03515 REV1; DNA repair protein REV1 [EC:2.7.7.-]
C B-family DNA polymerases
D 116925537 DNA polymerase zeta catalytic subunit K02350 REV3L; DNA polymerase zeta [EC:2.7.7.7]
C A-family DNA polymerase
C Rad6 epistasis group
D 116918131 ubiquitin-conjugating enzyme E2-17 kDa K10573 UBE2A; ubiquitin-conjugating enzyme E2 A [EC:2.3.2.23]
D 116932812 E3 ubiquitin-protein ligase RAD18 isoform X1 K10627 RAD18; E3 ubiquitin-protein ligase RAD18 [EC:2.3.2.27]
D 116924805 ubiquitin-conjugating enzyme E2 N K10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23]
C Other TLS factors
D 116924898 proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
D 116928952 DNA-dependent metalloprotease dvc-1 K24051 SPRTN; SprT-like domain-contaning protein Spartan
D 116932156 acidic repeat-containing protein K26957 GCNA; germ cell nuclear acidic protein
B Check point factors
C Rad9-Hus1-Rad1 complex
D 116921216 cell cycle checkpoint control protein RAD9A isoform X1 K10994 RAD9A; cell cycle checkpoint control protein RAD9A [EC:3.1.11.2]
D 116923364 checkpoint protein HUS1 isoform X1 K10903 HUS1; HUS1 checkpoint protein
D 116930257 cell cycle checkpoint protein RAD1 isoform X1 K02830 HRAD1; cell cycle checkpoint protein [EC:3.1.11.2]
C HRAD17(Rad24)-RFC complex
D 123466247 cell cycle checkpoint protein RAD17-like isoform X1 K06662 HRAD17; cell cycle checkpoint protein
D 116933118 replication factor C subunit 4 K10755 RFC2_4; replication factor C subunit 2/4
D 116915837 replication factor C subunit 2 K10755 RFC2_4; replication factor C subunit 2/4
D 116924347 replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
D 116924752 replication factor C subunit 5 K10756 RFC3_5; replication factor C subunit 3/5
C Rad17-Mec3-Ddc1 complex
D 116930257 cell cycle checkpoint protein RAD1 isoform X1 K02830 HRAD1; cell cycle checkpoint protein [EC:3.1.11.2]
C FPC (fork protection complex)
D 116923421 protein timeless homolog K10997 TIMELESS; replication fork protection complex subunit TIMELESS/Tof1/Swi1
D 116933127 TIMELESS-interacting protein K10998 TIPIN; replication fork protection complex subunit TIPIN/Csm3/Swi3
D 116917779 claspin isoform X1 K25773 CLSPN; claspin
C Triple T complex
D 116926492 TELO2-interacting protein 1 homolog K20403 TTI1; TELO2-interacting protein 1
D 116920718 uncharacterized protein LOC116920718 K23115 TTI2; TELO2-interacting protein 2
C BAG6-UBL4A-GET4 complex
D 116926014 large proline-rich protein BAG6 K23390 BAG6; large proline-rich protein BAG6
D 116916883 NEDD8 K23388 UBL4; ubiquitin-like protein 4
D 116920115 Golgi to ER traffic protein 4 homolog K23387 GET4; golgi to ER traffic protein 4
C Other check point factors
D 116929803 serine/threonine-protein kinase ATR K06640 ATR; serine/threonine-protein kinase ATR [EC:2.7.11.1]
D 116931082 uncharacterized protein LOC116931082 isoform X1 K10905 ATRIP; ATR interacting protein
D 116926286 serine-protein kinase ATM K04728 ATM; serine-protein kinase ATM [EC:2.7.11.1]
D 116930871 serine/threonine-protein kinase grp K02216 CHEK1; serine/threonine-protein kinase CHEK1 [EC:2.7.11.1]
D 116919216 serine/threonine-protein kinase Chk2 isoform X1 K06641 CHEK2; serine/threonine-protein kinase CHEK2 [EC:2.7.11.1]
D 116930931 M-phase inducer phosphatase 1 isoform X1 K05866 CDC25B; M-phase inducer phosphatase 2 [EC:3.1.3.48]
D 116924937 14-3-3 protein zeta isoform X1 K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
D 116922995 14-3-3 protein epsilon isoform X1 K06630 YWHAE; 14-3-3 protein epsilon
D 116931522 neuron navigator 2 isoform X1 K19483 NAV2; neuron navigator 2 [EC:5.6.2.4]
D 116932686 wee1-like protein kinase K06632 WEE1; wee1-like protein kinase [EC:2.7.11.1]
D 116916860 period circadian protein K02633 PER2; period circadian protein 2
D 116916105 mediator of DNA damage checkpoint protein 1 K20780 MDC1; mediator of DNA damage checkpoint protein 1
D 116931678 plastin-1 isoform X1 K17336 PLS3; plastin-3
D 116935050 protein downstream neighbor of son homolog K22422 DONSON; protein downstream neighbor of Son
D 116930455 KN motif and ankyrin repeat domain-containing protein 3 isoform X1 K22808 KANK; KN motif and ankyrin repeat domain-containing protein
D 116931820 vacuolar protein sorting-associated protein 4 K12196 VPS4; vacuolar protein-sorting-associated protein 4
D 116921646 abscission/NoCut checkpoint regulator K24778 ZFYVE19; abscission/NoCut checkpoint regulator
B Other factors with a suspected DNA repair function
C DNA polymerases
D 116923436 DNA polymerase theta K02349 POLQ; DNA polymerase theta [EC:2.7.7.7]
D 116918381 myb-binding protein 1A-like protein K02331 POL5; DNA polymerase phi [EC:2.7.7.7]
D 116932168 DNA-directed primase/polymerase protein isoform X1 K22761 PRIMPOL; DNA-directed primase/polymerase protein [EC:2.7.7.102 2.7.7.7]
C Nucleases
D 116920063 three-prime repair exonuclease 1 K10790 TREX1; three prime repair exonuclease 1 [EC:3.1.11.2]
D 123471194 three-prime repair exonuclease 1-like K10790 TREX1; three prime repair exonuclease 1 [EC:3.1.11.2]
D 116918717 three prime repair exonuclease 2 isoform X1 K10791 TREX2; three prime repair exonuclease 2 [EC:3.1.11.2]
D 116920346 LOW QUALITY PROTEIN: three-prime repair exonuclease 1 K10791 TREX2; three prime repair exonuclease 2 [EC:3.1.11.2]
D 116926469 DNA cross-link repair 1A protein K15340 DCLRE1A; DNA cross-link repair 1A protein
D 116925567 5' exonuclease Apollo K15341 DCLRE1B; DNA cross-link repair 1B protein [EC:3.1.-.-]
D 116925112 endonuclease V K21813 ENDOV; endonuclease V [EC:3.1.26.-]
D 116921830 ankyrin repeat and LEM domain-containing protein 1 K21411 ANKLE1; ankyrin repeat and LEM domain-containing protein 1
C Helicases
D 116929820 LOW QUALITY PROTEIN: helicase POLQ-like K19178 HELQ; POLQ-like helicase [EC:5.6.2.4]
C PSO4 complex
D 116916700 pre-mRNA-processing factor 19 K10599 PRPF19; pre-mRNA-processing factor 19 [EC:2.3.2.27]
D 116919153 pre-mRNA-splicing factor SPF27 K12861 BCAS2; pre-mRNA-splicing factor SPF27
D 116929450 pleiotropic regulator 1 isoform X1 K12862 PLRG1; pleiotropic regulator 1
C Modulation of nucleotide pools
D 116934594 7,8-dihydro-8-oxoguanine triphosphatase-like K17816 NUDT1; 8-oxo-dGTP diphosphatase / 2-hydroxy-dATP diphosphatase [EC:3.6.1.55 3.6.1.56]
D 116926866 7,8-dihydro-8-oxoguanine triphosphatase K17816 NUDT1; 8-oxo-dGTP diphosphatase / 2-hydroxy-dATP diphosphatase [EC:3.6.1.55 3.6.1.56]
D 116924793 8-oxo-dGDP phosphatase NUDT18 isoform X1 K17817 NUDT18; 8-oxo-dGDP phosphatase [EC:3.6.1.58]
D 116928539 deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 116933831 ribonucleoside-diphosphate reductase large subunit K10807 RRM1; ribonucleoside-diphosphate reductase subunit M1 [EC:1.17.4.1]
D 116931048 ribonucleoside-diphosphate reductase subunit M2 K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]
#
AProkaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D 116919804 deoxyribodipyrimidine photo-lyase isoform X1 K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]
C BER (base exicision repair)
D DNA glycosylases
E 116928056 uracil-DNA glycosylase K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E 116922578 single-strand selective monofunctional uracil DNA glycosylase K10800 SMUG1; single-strand selective monofunctional uracil DNA glycosylase [EC:3.2.2.-]
E 116921963 DNA-3-methyladenine glycosylase K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]
E 116933040 adenine DNA glycosylase isoform X1 K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
E 123469484 adenine DNA glycosylase-like isoform X1 K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
E 116926131 endonuclease III-like protein 1 isoform X1 K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
D RecJ
D DNA ligase
D DNA polymerase I
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase complex (RNAP)
E TRCF (transcription-repair coupling factor)
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
D Molecular matchmaker
D Strand discrimination factor
D DNA exonucleases
D DNA polymerase III holoenzyme
D DNA ligase
D Other MMR factors
E 116932713 single-stranded DNA-binding protein, mitochondrial K03111 ssb; single-strand DNA-binding protein
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D RecBC pathway proteins
D RecFOR pathway proteins
D AddAB pathway proteins
D Other HR factor
D Archaeal homologous recombinant proteins
C NHEJ (non-homologous end-joining)
D Two-component NHEJ DNA repair complex
D SHIIR (short-homology-independent illegitimate recombination)
E Facilitator
E Supressor
D SHDIR (short-homology-dependent illegitimate recombination)
E RecET pathway
E Facilitator
E Supressor
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
C Other SOS response factors
D 116932713 single-stranded DNA-binding protein, mitochondrial K03111 ssb; single-strand DNA-binding protein
B Other factors with a suspected DNA repair function
C DNA polymerase
C DNA helicases
C Modulation of nucleotide pools
D 116928539 deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
C Others
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#
#[ BRITE | KEGG2 | KEGG ]
#Last updated: March 29, 2024