+E Replication protein KO
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DNA Replication Proteins - Drosophila persimilis
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AEukaryotic type
B DNA Replication Initiation Factors
C pre-RC (pre-replication complex)
D 6602048 origin recognition complex subunit 1 K02603 ORC1; origin recognition complex subunit 1
D 6588526 origin recognition complex subunit 2 K02604 ORC2; origin recognition complex subunit 2
D 6593249 origin recognition complex subunit 3 K02605 ORC3; origin recognition complex subunit 3
D 6592273 origin recognition complex subunit 4 K02606 ORC4; origin recognition complex subunit 4
D 6598019 origin recognition complex subunit 5 K02607 ORC5; origin recognition complex subunit 5
D 6600946 origin recognition complex subunit 6 K02608 ORC6; origin recognition complex subunit 6
D 6602140 DNA replication factor Cdt1 K10727 CDT1; chromatin licensing and DNA replication factor 1
D 6602492 cell division control protein 6 homolog K02213 CDC6; cell division control protein 6
D 6587477 DNA replication licensing factor Mcm2 K02540 MCM2; DNA replication licensing factor MCM2 [EC:5.6.2.3]
D 6597502 DNA replication licensing factor Mcm3 K02541 MCM3; DNA replication licensing factor MCM3 [EC:5.6.2.3]
D 6602056 DNA replication licensing factor MCM4 K02212 MCM4; DNA replication licensing factor MCM4 [EC:5.6.2.3]
D 6591433 DNA replication licensing factor Mcm5 K02209 MCM5; DNA replication licensing factor MCM5 [EC:5.6.2.3]
D 6600228 DNA replication licensing factor Mcm6 K02542 MCM6; DNA replication licensing factor MCM6 [EC:5.6.2.3]
D 6602509 DNA replication licensing factor Mcm7 K02210 MCM7; DNA replication licensing factor MCM7 [EC:5.6.2.3]
C CDK (cyclin dependent kinase)
D 6600590 G2/mitotic-specific cyclin-A K06627 CCNA; cyclin-A
D 6603382 G1/S-specific cyclin-E K06626 CCNE; G1/S-specific cyclin-E1
D 6598840 cyclin-dependent kinase 2 K02206 CDK2; cyclin-dependent kinase 2 [EC:2.7.11.22]
C DDK (Dbf-4 dependent kinase)
D 6588941 cell division cycle 7-related protein kinase K02214 CDC7; cell division control protein 7 [EC:2.7.11.1]
D 6600147 cell division cycle 7-related protein kinase K02214 CDC7; cell division control protein 7 [EC:2.7.11.1]
C GINS complex
D 6601080 DNA replication complex GINS protein PSF1 K10732 GINS1; GINS complex subunit 1
D 6595554 probable DNA replication complex GINS protein PSF2 K10733 GINS2; GINS complex subunit 2
D 6600051 probable DNA replication complex GINS protein PSF3 K10734 GINS3; GINS complex subunit 3
D 6591676 DNA replication complex GINS protein SLD5 K10735 GINS4; GINS complex subunit 4
C Other initiation factors
D 6598516 DNA topoisomerase 2-binding protein 1-A K10728 TOPBP1; topoisomerase (DNA) II binding protein 1
D 113566726 ATP-dependent DNA helicase Q4 K10730 RECQL4; ATP-dependent DNA helicase Q4 [EC:5.6.2.4]
D 6596660 cell division control protein 45 homolog K06628 CDC45; cell division control protein 45
D 6591630 DNA replication licensing factor REC K10737 MCM8; DNA helicase MCM8 [EC:5.6.2.4]
D 6593672 protein MCM10 homolog K10736 MCM10; minichromosome maintenance protein 10
D 6593416 mini-chromosome maintenance complex-binding protein K28390 MCMBP; minichromosome maintenance complex-binding protein
D 6589162 uncharacterized protein LOC6589162 K26052 CINP; cyclin-dependent kinase 2-interacting protein
B DNA Replication Elongation Factors
C DNA polymerase alpha / primase complex
D 6591457 DNA polymerase alpha catalytic subunit K02320 POLA1; DNA polymerase alpha subunit A [EC:2.7.7.7]
D 6587733 DNA polymerase alpha subunit B K02321 POLA2; DNA polymerase alpha subunit B
D 6601208 DNA primase small subunit K02684 PRI1; DNA primase small subunit [EC:2.7.7.102]
D 6595986 DNA primase large subunit K02685 PRI2; DNA primase large subunit
C DNA polymerase epsilon complex
D 6594857 DNA polymerase epsilon catalytic subunit A K02324 POLE; DNA polymerase epsilon subunit 1 [EC:2.7.7.7]
D 6602933 DNA polymerase epsilon subunit 2 K02325 POLE2; DNA polymerase epsilon subunit 2 [EC:2.7.7.7]
D 6593533 DNA polymerase epsilon subunit 3 K02326 POLE3; DNA polymerase epsilon subunit 3 [EC:2.7.7.7]
D 6604588 DNA polymerase epsilon subunit 3 K02326 POLE3; DNA polymerase epsilon subunit 3 [EC:2.7.7.7]
D 6592636 DNA polymerase epsilon subunit 4 K03506 POLE4; DNA polymerase epsilon subunit 4 [EC:2.7.7.7]
C DNA polymerase delta complex
D 6601864 DNA polymerase delta catalytic subunit K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
D 6601120 DNA polymerase delta small subunit K02328 POLD2; DNA polymerase delta subunit 2
D 6593576 nucleolar protein dao-5 K03504 POLD3; DNA polymerase delta subunit 3
C DNA polymerase gamma complex (mitochondrial)
D 6598013 DNA polymerase subunit gamma-1, mitochondrial K02332 POLG; DNA polymerase gamma 1 [EC:2.7.7.7]
D 6598020 DNA polymerase subunit gamma-2, mitochondrial K02333 POLG2; DNA polymerase gamma 2
C RPA (replication protein A)
D 6587200 replication protein A 70 kDa DNA-binding subunit K07466 RFA1; replication factor A1
D 6588686 replication protein A 32 kDa subunit K10739 RFA2; replication factor A2
D 113566189 replication protein A 14 kDa subunit A K10740 RPA3; replication factor A3
C RFC (replication factor C)
D 6591802 replication factor C subunit 1 K10754 RFC1; replication factor C subunit 1
D 6604201 LOW QUALITY PROTEIN: replication factor C subunit 1 K10754 RFC1; replication factor C subunit 1
D 6597566 replication factor C subunit 4 K10755 RFC2_4; replication factor C subunit 2/4
D 6601880 replication factor C subunit 2 K10755 RFC2_4; replication factor C subunit 2/4
D 6588806 replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
D 6589014 replication factor C subunit 5 K10756 RFC3_5; replication factor C subunit 3/5
C RNase H
D 113565248 ribonuclease H1 K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
D 6589874 ribonuclease H2 subunit A K10743 RNASEH2A; ribonuclease H2 subunit A [EC:3.1.26.4]
D 6602658 ribonuclease H2 subunit B isoform X1 K10744 RNASEH2B; ribonuclease H2 subunit B
D 6592497 ribonuclease H2 subunit C K10745 RNASEH2C; ribonuclease H2 subunit C
C Other elongation factors
D 6593170 proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
D 6593988 proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
D 6597908 DNA replication ATP-dependent helicase/nuclease DNA2 K10742 DNA2; DNA replication ATP-dependent helicase/nuclease Dna2 [EC:5.6.2.3 3.1.-.-]
D 6592701 flap endonuclease 1 K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
D 6589213 LOW QUALITY PROTEIN: exonuclease 1 K10746 EXO1; exonuclease 1 [EC:3.1.-.-]
D 6599800 ATPase family AAA domain-containing protein 5 K26118 ATAD5; ATPase family AAA domain-containing protein 5
B DNA Replication Termination Factors
C DNA methylation enzymes
C Prevention of re-replication factors
D 6600809 geminin K10749 GMNN; geminin
D 6588946 G2/mitotic-specific cyclin-B K21770 CCNB2; G2/mitotic-specific cyclin-B2
D 6590086 G2/mitotic-specific cyclin-B K21770 CCNB2; G2/mitotic-specific cyclin-B2
D 6595015 G2/mitotic-specific cyclin-B K21770 CCNB2; G2/mitotic-specific cyclin-B2
D 6589722 G2/mitotic-specific cyclin-B3 K21771 CCNB3; G2/mitotic-specific cyclin-B3
D 6595286 G2/mitotic-specific cyclin-B3 K21771 CCNB3; G2/mitotic-specific cyclin-B3
D 6589331 cyclin-dependent kinase 1 K02087 CDK1; cyclin-dependent kinase 1 [EC:2.7.11.22 2.7.11.23]
C Telomere proteins
D Shelterin complex
D TERB1-TERB2-MAJIN complex
D CST complex (animals)
D CST complex (yeast)
D RIF proteins
D SIR proteins
C Telomerase complex (animals)
D 6588089 telomerase-binding protein EST1A K11124 SMG6; protein SMG6 [EC:3.1.-.-]
D 6598000 protein SMG5 isoform X1 K11125 SMG5; protein SMG5
D Dyskerin complex
E 6602032 LOW QUALITY PROTEIN: keratin, type II cytoskeletal 1 K11128 GAR1; H/ACA ribonucleoprotein complex subunit 1
E 6597111 H/ACA ribonucleoprotein complex subunit 2-like protein K11129 NHP2; H/ACA ribonucleoprotein complex subunit 2
E 6592518 H/ACA ribonucleoprotein complex subunit 3 K11130 NOP10; H/ACA ribonucleoprotein complex subunit 3
E 113565094 H/ACA ribonucleoprotein complex subunit 4-like K11131 DKC1; H/ACA ribonucleoprotein complex subunit 4 [EC:5.4.99.-]
E 6601338 H/ACA ribonucleoprotein complex subunit 4 K11131 DKC1; H/ACA ribonucleoprotein complex subunit 4 [EC:5.4.99.-]
C Telomerase complex (fungi)
D Sm core complex
E 6588960 small nuclear ribonucleoprotein-associated protein B K11086 SNRPB; small nuclear ribonucleoprotein B and B'
E 6595971 probable small nuclear ribonucleoprotein Sm D1 K11087 SNRPD1; small nuclear ribonucleoprotein D1
E 6588036 probable small nuclear ribonucleoprotein Sm D2 K11096 SNRPD2; small nuclear ribonucleoprotein D2
E 6591176 small nuclear ribonucleoprotein Sm D3 K11088 SNRPD3; small nuclear ribonucleoprotein D3
E 113565670 probable small nuclear ribonucleoprotein E K11097 SNRPE; small nuclear ribonucleoprotein E
E 6590199 small nuclear ribonucleoprotein F K11098 SNRPF; small nuclear ribonucleoprotein F
E 6587774 probable small nuclear ribonucleoprotein G K11099 SNRPG; small nuclear ribonucleoprotein G
C ELG1-RFC complex
D 6597566 replication factor C subunit 4 K10755 RFC2_4; replication factor C subunit 2/4
D 6601880 replication factor C subunit 2 K10755 RFC2_4; replication factor C subunit 2/4
D 6588806 replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
D 6589014 replication factor C subunit 5 K10756 RFC3_5; replication factor C subunit 3/5
C MRN complex
D 6589008 double-strand break repair protein MRE11 K10865 MRE11; double-strand break repair protein MRE11
D 6592385 DNA repair protein RAD50 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
D 6602780 nibrin K10867 NBN; nibrin
C Other termination factors
D 6594101 serine/threonine-protein kinase ATM K04728 ATM; serine-protein kinase ATM [EC:2.7.11.1]
D 6594718 Bloom syndrome protein homolog K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
D 6596827 DNA repair endonuclease XPF K10848 ERCC4; DNA excision repair protein ERCC-4 [EC:3.1.-.-]
D 6594376 poly [ADP-ribose] polymerase K24070 PARP1; poly [ADP-ribose] polymerase 1 [EC:2.4.2.30]
D 6592011 LOW QUALITY PROTEIN: tankyrase K10799 TNKS; tankyrase [EC:2.4.2.30]
D 6592555 PIN2/TERF1-interacting telomerase inhibitor 1 isoform X1 K11135 PINX1; Pin2-interacting protein X1
D 6596883 regulator of telomere elongation helicase 1 homolog K11136 RTEL1; regulator of telomere elongation helicase 1 [EC:5.6.2.3]
D 6589747 ATP-dependent DNA helicase PIF1 K15255 PIF1; ATP-dependent DNA helicase PIF1 [EC:5.6.2.3]
D 6602003 transcriptional activator protein Pur-beta isoform X2 K21772 PURA; transcriptional activator protein Pur-alpha
D 113565777 telomerase Cajal body protein 1 homolog K23314 WRAP53; telomerase Cajal body protein 1
D 6588550 replication stress response regulator SDE2 K25059 SDE2; replication stress response regulator SDE2
D 6596650 protein RTF2 homolog K25186 RTF2; replication termination factor 2
B DNA Topoisomerases
C 6597586 DNA topoisomerase 1 isoform X1 K03163 TOP1; DNA topoisomerase I [EC:5.6.2.1]
C 6597966 DNA topoisomerase 2 K03164 TOP2; DNA topoisomerase II [EC:5.6.2.2]
C 6597946 DNA topoisomerase 3-alpha K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
C 6598290 DNA topoisomerase 3-beta K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
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AProkaryotic type
B DNA Replication Initiation Factors
C Initiation factors (bacterial)
D 6594131 single-stranded DNA-binding protein, mitochondrial K03111 ssb; single-strand DNA-binding protein
C Initiation factors (archaeal)
B DNA Replication Elongation Factors
C Elongation factors (bacterial)
D DNA polymerase III holoenzyme
D RNase H
E 113565248 ribonuclease H1 K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
D Other elongation factors
C Elongation factors (archaeal)
D B-family DNA polymerases
D D-family DNA polymerases
D RNase H
E 113565248 ribonuclease H1 K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
D RFC (replication factor C)
D Other elongation factors
E 6597908 DNA replication ATP-dependent helicase/nuclease DNA2 K10742 DNA2; DNA replication ATP-dependent helicase/nuclease Dna2 [EC:5.6.2.3 3.1.-.-]
E 6592701 flap endonuclease 1 K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
B DNA Replication Termination Factors
C Terminus site-binding protein
C DNA methylation enzymes
C Prevention of re-replication factors
B DNA Topoisomerases
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: August 27, 2025