+D Receptor KO
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G Protein-Coupled Receptors - Daphnia pulex (common water flea)
%
!
ARhodopsin family
B Biogenic amine
C Acetylcholine (muscarinic)
D DAPPUDRAFT_48172 Gpr1; hypothetical protein K04131 CHRM3; muscarinic acetylcholine receptor M3
C Adrenaline
D DAPPUDRAFT_66063 hypothetical protein K04136 ADRA1B; adrenergic receptor alpha-1B
C Dopamine
D DAPPUDRAFT_23898 hypothetical protein K04144 DRD1; dopamine receptor D1
D DAPPUDRAFT_253332 hypothetical protein K04144 DRD1; dopamine receptor D1
D DAPPUDRAFT_325397 hypothetical protein K04144 DRD1; dopamine receptor D1
D DAPPUDRAFT_56664 Dop-R; hypothetical protein K04145 DRD2; dopamine receptor D2
D DAPPUDRAFT_22045 hypothetical protein K04148 DRD1N; dopamine receptor D1-like
D DAPPUDRAFT_23736 hypothetical protein K04148 DRD1N; dopamine receptor D1-like
D DAPPUDRAFT_45558 DOP-R; hypothetical protein K04148 DRD1N; dopamine receptor D1-like
C Dopamine and ecdysteroid
D DAPPUDRAFT_218187 hypothetical protein K22919 DopEcR; dopamine/ecdysteroid receptor
C Histamine
C Octopamine and tryamine
D DAPPUDRAFT_42083 hypothetical protein K04165 Oamb; octopamine receptor
D DAPPUDRAFT_213639 Gpr2; hypothetical protein K22814 Octalpha; octopamine receptor alpha
D DAPPUDRAFT_347041 Octopamine receptor beta-2-like protein K22790 Octbeta; octopamine receptor beta
C Serotonin
D DAPPUDRAFT_100265 hypothetical protein K04153 HTR1; 5-hydroxytryptamine receptor 1
D DAPPUDRAFT_100280 hypothetical protein K04153 HTR1; 5-hydroxytryptamine receptor 1
D DAPPUDRAFT_42951 SerR.2; serotonin receptor-like protein K04153 HTR1; 5-hydroxytryptamine receptor 1
D DAPPUDRAFT_43211 SerR.1; serotonin receptor-like protein K04153 HTR1; 5-hydroxytryptamine receptor 1
D DAPPUDRAFT_23299 SerR; hypothetical protein K04163 HTR7; 5-hydroxytryptamine receptor 7
C Trace amine
B Peptide
C Adrenomedullin (G10D)
C Adropin
C Apelin
C Anaphylatoxin
C Angiotensin
C BigLEN
C Bombesin
D DAPPUDRAFT_2679 putative allatostatin B receptor K04170 BRS3; bombesin receptor subtype-3
D DAPPUDRAFT_318294 hypothetical protein K04170 BRS3; bombesin receptor subtype-3
D DAPPUDRAFT_32108 putative allatostatin B receptor K04170 BRS3; bombesin receptor subtype-3
D DAPPUDRAFT_43250 putative allatostatin B receptor K04170 BRS3; bombesin receptor subtype-3
C Bradykinin
C Cholecystokinin
D DAPPUDRAFT_109099 hypothetical protein K04194 CCKAR; cholecystokinin A receptor
D DAPPUDRAFT_317149 hypothetical protein K04194 CCKAR; cholecystokinin A receptor
D DAPPUDRAFT_53990 putative sulfakinin receptor K04194 CCKAR; cholecystokinin A receptor
C Endothelin
C fMet-Leu-Phe
C Follicle stimulating hormone (FSH)
C Galanin
D DAPPUDRAFT_120392 putative allatostatin A receptor K04233 ASTA-R; allatostatin A receptor
D DAPPUDRAFT_13548 putative allatostatin A receptor K04233 ASTA-R; allatostatin A receptor
D DAPPUDRAFT_60654 putative allatostatin A receptor K04233 ASTA-R; allatostatin A receptor
C Ghrelin
C Gonadotropin-releasing hormone (GnRH)
D DAPPUDRAFT_312207 hypothetical protein K04280 GNRHR; gonadotropin-releasing hormone receptor
D DAPPUDRAFT_40643 hypothetical protein K28251 AkhR; adipokinetic hormone receptor
C Lutropin-choriogonadotropic hormone
C Melanin-concentrating hormone (MCH)
C Melanocortin
C Motilin
D DAPPUDRAFT_21055 putative neuropeptide G protein-coupled receptor K05266 MLNR; motilin receptor
C Neuromedin U
D DAPPUDRAFT_57322 putative capa receptor K05052 NMUR1; neuromedin U receptor 1
C Neuropeptide FF
D DAPPUDRAFT_23370 SIFamide receptor-like protein K08375 NPFFR2; neuropeptide FF receptor 2
D DAPPUDRAFT_305405 hypothetical protein K08375 NPFFR2; neuropeptide FF receptor 2
C Neuropeptide S
D DAPPUDRAFT_317355 hypothetical protein K08376 NPSR1; neuropeptide S receptor
C Neuropeptide W / neuropeptide B
C Neuropeptide Y
D DAPPUDRAFT_12943 hypothetical protein K04210 GPR83; G protein-coupled receptor 83
D DAPPUDRAFT_23465 putative sNPF receptor K04209 NPFR; neuropeptide F receptor
D DAPPUDRAFT_2440 hypothetical protein K04209 NPFR; neuropeptide F receptor
D DAPPUDRAFT_299730 NPFG-protein-coupled receptor K04209 NPFR; neuropeptide F receptor
D DAPPUDRAFT_299731 NPFG-protein-coupled receptor K04209 NPFR; neuropeptide F receptor
D DAPPUDRAFT_299732 NPFG-protein-coupled receptor K04209 NPFR; neuropeptide F receptor
D DAPPUDRAFT_330424 hypothetical protein K04209 NPFR; neuropeptide F receptor
C Neurotensin
C Opioid
C Orexigenic neuropeptide QRFP
D DAPPUDRAFT_58666 putative neuropeptide G protein-coupled receptor K08378 QRFPR; pyroglutamylated RFamide peptide receptor
C Orexin
D DAPPUDRAFT_234062 putative neuropeptide receptor K04239 HCRTR2; hypocretin (orexin) receptor 2
C Oxytocin
D DAPPUDRAFT_290621 putative vasopressin/oxytocin receptor K04229 OXTR; oxytocin receptor
C Prokineticin
C Prolactin-releasing peptide (PrRP)
C Prosaposin
C Relaxin
C Somatostatin
D DAPPUDRAFT_12571 putative allatostatin C receptor K22872 ASTC-R; allatostatin C receptor
D DAPPUDRAFT_12576 hypothetical protein K22872 ASTC-R; allatostatin C receptor
C Tachykinin
D DAPPUDRAFT_41569 putative tachykinin-like receptor K04224 TACR3; tachykinin receptor 3
D DAPPUDRAFT_54432 hypothetical protein K04224 TACR3; tachykinin receptor 3
D DAPPUDRAFT_54510 hypothetical protein K04224 TACR3; tachykinin receptor 3
D DAPPUDRAFT_1937 putative NPY-like neuropeptide receptor K14072 Rya-R; RYamide receptor
C Thrombin
C Thyrotropin
D DAPPUDRAFT_290661 LGR1; hypothetical protein K04249 TSHR; thyrotropin receptor
C Thyrotropin-releasing hormone (TRH)
D DAPPUDRAFT_22381 hypothetical protein K04282 TRHR; thyrotropin-releasing hormone receptor
C Urotensin II
C Vasopressin
C Neuropeptide receptors
D DAPPUDRAFT_2282 putative neuropeptide receptor K26200 SPR; sex peptide receptor
D DAPPUDRAFT_311889 hypothetical protein K26201 FMRFaR; FMRFamide receptor
D DAPPUDRAFT_241971 putative proctolin receptor K26202 Proc-R; proctolin receptor
D DAPPUDRAFT_44675 putative myosuppressin receptor 1 K26203 MsR; myosuppressin receptor
B Chemokine
C CC Chemokine
C CXC Chemokine
C CX3C Chemokine
C C Chemokine
C Chemokine like
B Base and nucleoside
C Purine / pyrimidine
C Adenosine
B Lipid
C Arachidonylglycine
C Bile acid
C Cysteinyl leukotriene
C Free fatty acid
C HETE and oxoETE
C Leukotriene
C Lysophosphatidic acid
C Lysophosphatidylinositol
C Lysophosphatidylserine
C Oleoylethanolamide
C Prostaglandin
C Prostacyclin
C Sphingolipid
C Thromboxane
B Vision
C Opsin
D DAPPUDRAFT_247441 hypothetical protein K04250 RHO; rhodopsin
D DAPPUDRAFT_106425 hypothetical protein K04256 OPN3; c-opsin
D DAPPUDRAFT_346957 PTEROPSIN1; pteropsin1 K04256 OPN3; c-opsin
D DAPPUDRAFT_346958 PTEROPSIN3; pteropsin3 K04256 OPN3; c-opsin
D DAPPUDRAFT_346959 PTEROPSIN4; pteropsin4 K04256 OPN3; c-opsin
D DAPPUDRAFT_346964 PTEROPSIN6; pteropsin6 K04256 OPN3; c-opsin
D DAPPUDRAFT_346984 PTEROPSIN7; pteropsin7 K04256 OPN3; c-opsin
D DAPPUDRAFT_346985 PTEROPSIN8; pteropsin8 K04256 OPN3; c-opsin
D DAPPUDRAFT_346986 PTEROPSIN9; pteropsin9 K04256 OPN3; c-opsin
D DAPPUDRAFT_106095 LOPB5; hypothetical protein K04255 OPN4; r-opsin
D DAPPUDRAFT_223107 ARTHROPSIN7; arthropsin7 K04255 OPN4; r-opsin
D DAPPUDRAFT_302464 LOPA6; hypothetical protein K04255 OPN4; r-opsin
D DAPPUDRAFT_305771 LOPB2; hypothetical protein K04255 OPN4; r-opsin
D DAPPUDRAFT_305772 LOPB6; hypothetical protein K04255 OPN4; r-opsin
D DAPPUDRAFT_305803 LOPB4; hypothetical protein K04255 OPN4; r-opsin
D DAPPUDRAFT_306275 LOPA4; hypothetical protein K04255 OPN4; r-opsin
D DAPPUDRAFT_307030 LOPA2; hypothetical protein K04255 OPN4; r-opsin
D DAPPUDRAFT_307031 LOPA1; hypothetical protein K04255 OPN4; r-opsin
D DAPPUDRAFT_321382 LOPB7; hypothetical protein K04255 OPN4; r-opsin
D DAPPUDRAFT_346930 UNOP1; hypothetical protein K04255 OPN4; r-opsin
D DAPPUDRAFT_346935 UNOP2; hypothetical protein K04255 OPN4; r-opsin
D DAPPUDRAFT_346936 BLOP; blue wavelength opsin K04255 OPN4; r-opsin
D DAPPUDRAFT_346937 UVOP; UV wavelength opsin K04255 OPN4; r-opsin
D DAPPUDRAFT_346938 ARTHROPSIN1; arthropsin1 K04255 OPN4; r-opsin
D DAPPUDRAFT_346939 ARTHROPSIN2; arthropsin2 K04255 OPN4; r-opsin
D DAPPUDRAFT_346940 ARTHROPSIN3; arthropsin3 K04255 OPN4; r-opsin
D DAPPUDRAFT_346941 ARTHROPSIN4; arthropsin4 K04255 OPN4; r-opsin
D DAPPUDRAFT_346942 ARTHROPSIN5; arthropsin5 K04255 OPN4; r-opsin
D DAPPUDRAFT_346943 ARTHROPSIN6; arthropsin6 K04255 OPN4; r-opsin
D DAPPUDRAFT_346945 ARTHROPSIN8; arthropsin8 K04255 OPN4; r-opsin
D DAPPUDRAFT_346967 LOPA9; hypothetical protein K04255 OPN4; r-opsin
D DAPPUDRAFT_346968 LOPA10; LOPA10 K04255 OPN4; r-opsin
D DAPPUDRAFT_346974 LOPB1; hypothetical protein K04255 OPN4; r-opsin
D DAPPUDRAFT_346975 LOPB3; hypothetical protein K04255 OPN4; r-opsin
D DAPPUDRAFT_346976 LOPB8; hypothetical protein K04255 OPN4; r-opsin
D DAPPUDRAFT_346977 LOPB9; hypothetical protein K04255 OPN4; r-opsin
D DAPPUDRAFT_346979 LOPB13; hypothetical protein K04255 OPN4; r-opsin
D DAPPUDRAFT_346980 LOPB14; long wavelength opsin B14 K04255 OPN4; r-opsin
D DAPPUDRAFT_346981 LOPB15; hypothetical protein K04255 OPN4; r-opsin
D DAPPUDRAFT_67015 LOPA3; hypothetical protein K04255 OPN4; r-opsin
D DAPPUDRAFT_93838 LOPA8; hypothetical protein K04255 OPN4; r-opsin
D DAPPUDRAFT_194423 hypothetical protein K08385 OPN5; G0-opsin
D DAPPUDRAFT_328922 hypothetical protein K08385 OPN5; G0-opsin
B Others
C Alpha-ketoglutarate
C Cannabinoid
D DAPPUDRAFT_253818 hypothetical protein K04277 CNR1; cannabinoid receptor 1
C Estrogen
C Hydroxy-carboxylic acid
C L-Tryptophan and L-Phenylalanine
C Mas proto-oncogene and Mas-related (MRGs)
C Melatonin
C Oxysterol
C Platelet activating factor
C Proton-sensing GPCRs
C R-spondin
D DAPPUDRAFT_45411 LGR2; hypothetical protein K08399 LGR6; leucine-rich repeat-containing G protein-coupled receptor 6
C Super conserved receptor expressed in brain (SREB)
C Trissin
C Orphan GPCRs / unclassified GPCRs
D DAPPUDRAFT_3691 hypothetical protein K22873 TRE1; protein trapped in endoderm-1
D DAPPUDRAFT_50880 hypothetical protein K08439 GPR161; G protein-coupled receptor 161
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ASecretin receptor family
B Calcium-regulating peptide
C Calcitonin
D DAPPUDRAFT_299723 putative DH31 receptor K04577 CALCRL; calcitonin receptor-like
C Parathyroid hormone
D DAPPUDRAFT_299719 putative G-protein coupled receptor, orphan K04585 PTH1R; parathyroid hormone receptor 1
B Hypothalamic hormone
C Corticotropin-releasing hormone (CRH)
D DAPPUDRAFT_290680 putative diuretic hormone 44 receptor K04578 CRHR1; corticotropin releasing hormone receptor 1
D DAPPUDRAFT_62157 putative diuretic hormone 44 receptor K04578 CRHR1; corticotropin releasing hormone receptor 1
C Growth hormone-releasing hormone (GHRH)
B Pancreatic peptide
C Glucagon
B Gut peptide
C Gastric inhibitory peptide (GIP)
C Vasoactive intestinal polypeptide (VIP) and pituitary adenyl cyclase-activating peptide (PACAP)
C Secretin
B Others
C Receptor activity modifying protein
C Methuselah-like proteins (MTH)
D DAPPUDRAFT_100983 hypothetical protein K04599 MTH; G protein-coupled receptor Mth (Methuselah protein)
D DAPPUDRAFT_233474 hypothetical protein K04599 MTH; G protein-coupled receptor Mth (Methuselah protein)
D DAPPUDRAFT_240534 hypothetical protein K04599 MTH; G protein-coupled receptor Mth (Methuselah protein)
D DAPPUDRAFT_240555 hypothetical protein K04599 MTH; G protein-coupled receptor Mth (Methuselah protein)
D DAPPUDRAFT_240561 hypothetical protein K04599 MTH; G protein-coupled receptor Mth (Methuselah protein)
D DAPPUDRAFT_252060 hypothetical protein K04599 MTH; G protein-coupled receptor Mth (Methuselah protein)
D DAPPUDRAFT_302147 hypothetical protein K04599 MTH; G protein-coupled receptor Mth (Methuselah protein)
D DAPPUDRAFT_303269 hypothetical protein K04599 MTH; G protein-coupled receptor Mth (Methuselah protein)
D DAPPUDRAFT_310324 hypothetical protein K04599 MTH; G protein-coupled receptor Mth (Methuselah protein)
D DAPPUDRAFT_310325 hypothetical protein K04599 MTH; G protein-coupled receptor Mth (Methuselah protein)
D DAPPUDRAFT_316706 hypothetical protein K04599 MTH; G protein-coupled receptor Mth (Methuselah protein)
C Pigment dispersing factor (PDF)
D DAPPUDRAFT_299720 putative PDF receptor variant 2 K22738 PDFR; PDF receptor
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AAdhesion receptor family
B Cadherin EGF LAG (CELSR)
C DAPPUDRAFT_311854 hypothetical protein K04600 CELSR1; cadherin EGF LAG seven-pass G-type receptor 1
B EGF-like module-containing mucin-like hormone receptor-like (EMR)
B Latrophilin
C DAPPUDRAFT_101007 hypothetical protein K04593 ADGRL2; adhesion G protein-coupled receptor L2
B Brain-specific angiogenesis inhibitor (BAI)
B Others
C DAPPUDRAFT_310752 hypothetical protein K08462 ADGRA3; adhesion G protein-coupled receptor A3
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AMetabotropic glutamate receptor family
B Glutamate (metabotropic)
C DAPPUDRAFT_44069 Grm1; glutamate receptor, metabotropic K04606 GRM3; metabotropic glutamate receptor 3
B GABA
C DAPPUDRAFT_193382 Gabbr1; gamma-aminobutyric acid B receptor K04615 GABBR; gamma-aminobutyric acid type B receptor
C DAPPUDRAFT_251832 Gabbr3; gamma-aminobutyric acid B receptor K04615 GABBR; gamma-aminobutyric acid type B receptor
C DAPPUDRAFT_346915 Gabbr2; gamma-aminobutyric acid B receptor K04615 GABBR; gamma-aminobutyric acid type B receptor
B Calcium-sensing
B Orphan GPRC5
C DAPPUDRAFT_336629 hypothetical protein K04623 BOSS; bride of sevenless protein
B Unclassified GPCRs
C DAPPUDRAFT_46663 hypothetical protein K08469 GPR158; G protein-coupled receptor 158
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AFrizzled / Smoothened family
B DAPPUDRAFT_346805 FZ1.2; Wnt-receptor frizzled-like protein variant 1 K02432 FZD1_7; frizzled 1/7
B DAPPUDRAFT_347539 FZ2.2; Wnt-receptor frizzled protein variant 2 K02375 FZD5_8; frizzled 5/8
B DAPPUDRAFT_318256 hypothetical protein K06226 SMO; smoothened
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AOthers
B Chemoreception
C Olfactory
C Taste
C Vomeronasal pheromone
C Insect odorant and taste
D DAPPUDRAFT_116535 DpuGr40; hypothetical protein K08471 GR; gustatory receptor
D DAPPUDRAFT_255662 DpuGr22; hypothetical protein K08471 GR; gustatory receptor
D DAPPUDRAFT_305579 DpuGr5; hypothetical protein K08471 GR; gustatory receptor
D DAPPUDRAFT_311619 DpuGr8; hypothetical protein K08471 GR; gustatory receptor
D DAPPUDRAFT_311770 hypothetical protein K08471 GR; gustatory receptor
D DAPPUDRAFT_312387 DpuGr56; hypothetical protein K08471 GR; gustatory receptor
D DAPPUDRAFT_315056 DpuGr53; hypothetical protein K08471 GR; gustatory receptor
D DAPPUDRAFT_318197 DpuGr58; hypothetical protein K08471 GR; gustatory receptor
D DAPPUDRAFT_321432 hypothetical protein K08471 GR; gustatory receptor
D DAPPUDRAFT_323020 DpuGr30; hypothetical protein K08471 GR; gustatory receptor
D DAPPUDRAFT_327060 DpuGr24; hypothetical protein K08471 GR; gustatory receptor
D DAPPUDRAFT_327106 DpuGr21; hypothetical protein K08471 GR; gustatory receptor
D DAPPUDRAFT_327171 DpuGr12; hypothetical protein K08471 GR; gustatory receptor
D DAPPUDRAFT_346811 DpuGr1; hypothetical protein K08471 GR; gustatory receptor
D DAPPUDRAFT_346813 DpuGr3; hypothetical protein K08471 GR; gustatory receptor
D DAPPUDRAFT_346819 DpuGr2; hypothetical protein K08471 GR; gustatory receptor
D DAPPUDRAFT_346837 DpuGr7; hypothetical protein K08471 GR; gustatory receptor
D DAPPUDRAFT_346838 DpuGr9; hypothetical protein K08471 GR; gustatory receptor
D DAPPUDRAFT_346840 DpuGr10; hypothetical protein K08471 GR; gustatory receptor
D DAPPUDRAFT_346841 DpuGr11; hypothetical protein K08471 GR; gustatory receptor
D DAPPUDRAFT_346842 DpuGr13; hypothetical protein K08471 GR; gustatory receptor
D DAPPUDRAFT_346843 DpuGr14; hypothetical protein K08471 GR; gustatory receptor
D DAPPUDRAFT_346844 DpuGr15; hypothetical protein K08471 GR; gustatory receptor
D DAPPUDRAFT_346846 DpuGr16; hypothetical protein K08471 GR; gustatory receptor
D DAPPUDRAFT_346847 DpuGr17; hypothetical protein K08471 GR; gustatory receptor
D DAPPUDRAFT_346848 DpuGr18; hypothetical protein K08471 GR; gustatory receptor
D DAPPUDRAFT_346849 DpuGr19; hypothetical protein K08471 GR; gustatory receptor
D DAPPUDRAFT_346850 DpuGr20; hypothetical protein K08471 GR; gustatory receptor
D DAPPUDRAFT_346851 DpuGr23; hypothetical protein K08471 GR; gustatory receptor
D DAPPUDRAFT_346855 DpuGr25; hypothetical protein K08471 GR; gustatory receptor
D DAPPUDRAFT_346856 DpuGr26P; hypothetical protein K08471 GR; gustatory receptor
D DAPPUDRAFT_346857 DpuGr27; hypothetical protein K08471 GR; gustatory receptor
D DAPPUDRAFT_346858 DpuGr28; hypothetical protein K08471 GR; gustatory receptor
D DAPPUDRAFT_346859 DpuGr29; hypothetical protein K08471 GR; gustatory receptor
D DAPPUDRAFT_346861 DpuGr31; hypothetical protein K08471 GR; gustatory receptor
D DAPPUDRAFT_346862 DpuGr32; hypothetical protein K08471 GR; gustatory receptor
D DAPPUDRAFT_346863 DpuGr33; hypothetical protein K08471 GR; gustatory receptor
D DAPPUDRAFT_346866 DpuGr36; hypothetical protein K08471 GR; gustatory receptor
D DAPPUDRAFT_346867 DpuGr37; hypothetical protein K08471 GR; gustatory receptor
D DAPPUDRAFT_346876 DpuGr39; hypothetical protein K08471 GR; gustatory receptor
D DAPPUDRAFT_346878 Dpugr41; hypothetical protein K08471 GR; gustatory receptor
D DAPPUDRAFT_346901 DpuGr55; hypothetical protein K08471 GR; gustatory receptor
D DAPPUDRAFT_346902 DpuGr57; hypothetical protein K08471 GR; gustatory receptor
D DAPPUDRAFT_346908 DpuGr54; hypothetical protein K08471 GR; gustatory receptor
D DAPPUDRAFT_346911 DpuGr4; hypothetical protein K08471 GR; gustatory receptor
D DAPPUDRAFT_96272 DpuGr6; hypothetical protein K08471 GR; gustatory receptor
C Nematode chemoreception
C Fungal mating pheromone
B Others
C Ocular albinism proteins
D DAPPUDRAFT_334109 hypothetical protein K08470 OA1; ocular albinism type 1 protein
C Neuronostatin
D DAPPUDRAFT_199743 hypothetical protein K22985 GPR107; G protein-coupled receptor 107
D DAPPUDRAFT_226872 hypothetical protein K22985 GPR107; G protein-coupled receptor 107
C Plant Mlo receptors
C cAMP signaling
C Bacterial rhodopsin
C Orphan GPCRs
D DAPPUDRAFT_307191 hypothetical protein K22988 TPRA1; transmembrane protein adipocyte-associated 1
!
#
#[ BRITE | KEGG2 | KEGG ]
#Last updated: April 22, 2025
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Classification taken and modified from GPCRDB