+E Replication protein KO
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DNA Replication Proteins - Dermacentor silvarum
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AEukaryotic type
B DNA Replication Initiation Factors
C pre-RC (pre-replication complex)
D 119433141 origin recognition complex subunit 1 K02603 ORC1; origin recognition complex subunit 1
D 119455370 origin recognition complex subunit 2-like K02604 ORC2; origin recognition complex subunit 2
D 119461361 origin recognition complex subunit 3 isoform X1 K02605 ORC3; origin recognition complex subunit 3
D 119455406 origin recognition complex subunit 4-like K02606 ORC4; origin recognition complex subunit 4
D 119442003 origin recognition complex subunit 5 K02607 ORC5; origin recognition complex subunit 5
D 119436072 DNA replication factor Cdt1 K10727 CDT1; chromatin licensing and DNA replication factor 1
D 119457635 cell division control protein 6 homolog K02213 CDC6; cell division control protein 6
D 119466528 DNA replication licensing factor mcm2 K02540 MCM2; DNA replication licensing factor MCM2 [EC:5.6.2.3]
D 119450558 DNA replication licensing factor MCM3 K02541 MCM3; DNA replication licensing factor MCM3 [EC:5.6.2.3]
D 119432598 DNA replication licensing factor mcm4-A-like K02212 MCM4; DNA replication licensing factor MCM4 [EC:5.6.2.3]
D 119457451 DNA replication licensing factor mcm5 K02209 MCM5; DNA replication licensing factor MCM5 [EC:5.6.2.3]
D 119456298 DNA replication licensing factor MCM6 K02542 MCM6; DNA replication licensing factor MCM6 [EC:5.6.2.3]
D 119443112 DNA replication licensing factor mcm7 K02210 MCM7; DNA replication licensing factor MCM7 [EC:5.6.2.3]
C CDK (cyclin dependent kinase)
D 119449683 cyclin-A1 K06627 CCNA; cyclin-A
D 119436039 G1/S-specific cyclin-E1-like K06626 CCNE; G1/S-specific cyclin-E1
D 119433377 cyclin-dependent kinase 2 K02206 CDK2; cyclin-dependent kinase 2 [EC:2.7.11.22]
C DDK (Dbf-4 dependent kinase)
D 119436515 cell division cycle 7-related protein kinase K02214 CDC7; cell division control protein 7 [EC:2.7.11.1]
D 119441947 uncharacterized protein LOC119441947 K06629 DBF4; protein DBF4
C GINS complex
D 119457612 DNA replication complex GINS protein PSF1 K10732 GINS1; GINS complex subunit 1
D 119446846 DNA replication complex GINS protein PSF2 isoform X3 K10733 GINS2; GINS complex subunit 2
D 119431937 DNA replication complex GINS protein PSF3-like K10734 GINS3; GINS complex subunit 3
D 119460538 DNA replication complex GINS protein SLD5-like K10735 GINS4; GINS complex subunit 4
C Other initiation factors
D 119435760 DNA topoisomerase 2-binding protein 1 K10728 TOPBP1; topoisomerase (DNA) II binding protein 1
D 119432177 ATP-dependent DNA helicase Q4 isoform X1 K10730 RECQL4; ATP-dependent DNA helicase Q4 [EC:5.6.2.4]
D 119432362 cell division control protein 45 homolog K06628 CDC45; cell division control protein 45
D 119433055 DNA helicase MCM8 isoform X1 K10737 MCM8; DNA helicase MCM8 [EC:5.6.2.4]
D 119442978 DNA helicase MCM9-like K10738 MCM9; DNA helicase MCM9 [EC:5.6.2.4]
D 119461025 protein MCM10 homolog K10736 MCM10; minichromosome maintenance protein 10
D 119463750 cyclin-dependent kinase 2-interacting protein isoform X1 K26052 CINP; cyclin-dependent kinase 2-interacting protein
D 119465906 uncharacterized protein LOC119465906 isoform X1 K26116 MTBP; Mdm2-binding protein
D 119436818 uncharacterized protein LOC119436818 K26117 TICRR; Treslin
B DNA Replication Elongation Factors
C DNA polymerase alpha / primase complex
D 119441919 DNA polymerase alpha catalytic subunit K02320 POLA1; DNA polymerase alpha subunit A [EC:2.7.7.7]
D 119450303 DNA polymerase alpha subunit B K02321 POLA2; DNA polymerase alpha subunit B
D 119462111 DNA primase small subunit-like K02684 PRI1; DNA primase small subunit [EC:2.7.7.102]
D 119466330 DNA primase large subunit K02685 PRI2; DNA primase large subunit
D 119433558 DNA primase large subunit isoform X1 K02685 PRI2; DNA primase large subunit
C DNA polymerase epsilon complex
D 119455662 DNA polymerase epsilon catalytic subunit A-like K02324 POLE; DNA polymerase epsilon subunit 1 [EC:2.7.7.7]
D 119461801 DNA polymerase epsilon subunit 2 K02325 POLE2; DNA polymerase epsilon subunit 2 [EC:2.7.7.7]
D 119457554 DNA polymerase epsilon subunit 3 K02326 POLE3; DNA polymerase epsilon subunit 3 [EC:2.7.7.7]
D 119434096 DNA polymerase epsilon subunit 4-like K03506 POLE4; DNA polymerase epsilon subunit 4 [EC:2.7.7.7]
C DNA polymerase delta complex
D 119431543 uncharacterized protein LOC119431543 K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
D 119450738 DNA polymerase delta catalytic subunit-like K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
D 119453189 DNA polymerase delta subunit 2 K02328 POLD2; DNA polymerase delta subunit 2
D 119450736 DNA polymerase delta subunit 3-like K03504 POLD3; DNA polymerase delta subunit 3
C DNA polymerase gamma complex (mitochondrial)
D 119457950 DNA polymerase subunit gamma-1 K02332 POLG; DNA polymerase gamma 1 [EC:2.7.7.7]
D 119457951 LOW QUALITY PROTEIN: DNA polymerase subunit gamma-1-like K02332 POLG; DNA polymerase gamma 1 [EC:2.7.7.7]
D 119453006 DNA polymerase subunit gamma-2, mitochondrial K02333 POLG2; DNA polymerase gamma 2
C RPA (replication protein A)
D 119446216 LOW QUALITY PROTEIN: replication protein A 70 kDa DNA-binding subunit-like K07466 RFA1; replication factor A1
D 119442067 replication protein A 32 kDa subunit-A-like K10739 RFA2; replication factor A2
D 119441331 replication protein A 14 kDa subunit K10740 RPA3; replication factor A3
C RFC (replication factor C)
D 119446165 replication factor C subunit 1 K10754 RFC1; replication factor C subunit 1
D 119443114 replication factor C subunit 4-like K10755 RFC2_4; replication factor C subunit 2/4
D 119436753 replication factor C subunit 2 K10755 RFC2_4; replication factor C subunit 2/4
D 119446721 replication factor C subunit 5-like K10756 RFC3_5; replication factor C subunit 3/5
D 119449820 replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
C RNase H
D 119431343 ribonuclease H1 K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
D 119459455 ribonuclease H2 subunit A-like K10743 RNASEH2A; ribonuclease H2 subunit A [EC:3.1.26.4]
D 119441648 ribonuclease H2 subunit B K10744 RNASEH2B; ribonuclease H2 subunit B
D 119452282 uncharacterized protein LOC119452282 K10745 RNASEH2C; ribonuclease H2 subunit C
C Other elongation factors
D 119436407 proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
D 119446446 DNA replication ATP-dependent helicase/nuclease DNA2-like K10742 DNA2; DNA replication ATP-dependent helicase/nuclease Dna2 [EC:5.6.2.3 3.1.-.-]
D 119466142 flap endonuclease 1-B-like K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
D 119464401 exonuclease 1 isoform X2 K10746 EXO1; exonuclease 1 [EC:3.1.-.-]
D 119452831 DNA ligase 1-like isoform X1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
B DNA Replication Termination Factors
C DNA methylation enzymes
D 119437376 DNA (cytosine-5)-methyltransferase 1 K00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]
D 119437377 DNA (cytosine-5)-methyltransferase 1 K00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]
D 119437390 DNA (cytosine-5)-methyltransferase 1 K00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]
D 119466625 DNA (cytosine-5)-methyltransferase 1 K00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]
D 119445458 DNA (cytosine-5)-methyltransferase 1 K00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]
C Prevention of re-replication factors
D 119446854 geminin isoform X1 K10749 GMNN; geminin
D 119459338 G2/mitotic-specific cyclin-B2-like K21770 CCNB2; G2/mitotic-specific cyclin-B2
D 119448553 G2/mitotic-specific cyclin-B K21770 CCNB2; G2/mitotic-specific cyclin-B2
D 119448563 G2/mitotic-specific cyclin-B2 K21770 CCNB2; G2/mitotic-specific cyclin-B2
D 119449171 G2/mitotic-specific cyclin-B2 K21770 CCNB2; G2/mitotic-specific cyclin-B2
D 119449186 uncharacterized protein LOC119449186 K21770 CCNB2; G2/mitotic-specific cyclin-B2
D 119441891 G2/mitotic-specific cyclin-B3 K21771 CCNB3; G2/mitotic-specific cyclin-B3
D 119462015 cyclin-dependent kinase 1-like K02087 CDK1; cyclin-dependent kinase 1 [EC:2.7.11.22 2.7.11.23]
D 119436559 cyclin-dependent kinase 1 isoform X2 K02087 CDK1; cyclin-dependent kinase 1 [EC:2.7.11.22 2.7.11.23]
C Telomere proteins
D Shelterin complex
E 119445724 uncharacterized protein LOC119445724 K11113 TERF2IP; telomeric repeat-binding factor 2-interacting protein 1
D TERB1-TERB2-MAJIN complex
D CST complex (animals)
D CST complex (yeast)
D RIF proteins
D SIR proteins
C Telomerase complex (animals)
D 119446153 LOW QUALITY PROTEIN: telomerase-binding protein EST1A-like K11124 SMG6; protein SMG6 [EC:3.1.-.-]
D 119446734 nonsense-mediated mRNA decay factor SMG5 isoform X1 K11125 SMG5; protein SMG5
D 119463959 LOW QUALITY PROTEIN: telomerase reverse transcriptase-like K11126 TERT; telomerase reverse transcriptase [EC:2.7.7.49]
D Dyskerin complex
E 119437030 H/ACA ribonucleoprotein complex subunit 1 isoform X1 K11128 GAR1; H/ACA ribonucleoprotein complex subunit 1
E 119464662 H/ACA ribonucleoprotein complex subunit 2-like protein K11129 NHP2; H/ACA ribonucleoprotein complex subunit 2
E 119441615 LOW QUALITY PROTEIN: H/ACA ribonucleoprotein complex subunit 4-like K11131 DKC1; H/ACA ribonucleoprotein complex subunit 4 [EC:5.4.99.-]
C Telomerase complex (fungi)
D 119463959 LOW QUALITY PROTEIN: telomerase reverse transcriptase-like K11126 TERT; telomerase reverse transcriptase [EC:2.7.7.49]
D Sm core complex
E 119435921 small nuclear ribonucleoprotein-associated protein B K11086 SNRPB; small nuclear ribonucleoprotein B and B'
E 119433583 small nuclear ribonucleoprotein Sm D1-like K11087 SNRPD1; small nuclear ribonucleoprotein D1
E 119457623 small nuclear ribonucleoprotein Sm D2 K11096 SNRPD2; small nuclear ribonucleoprotein D2
E 119446314 small nuclear ribonucleoprotein Sm D3 K11088 SNRPD3; small nuclear ribonucleoprotein D3
E 119446330 small nuclear ribonucleoprotein Sm D3 K11088 SNRPD3; small nuclear ribonucleoprotein D3
E 119436172 small nuclear ribonucleoprotein E-like K11097 SNRPE; small nuclear ribonucleoprotein E
E 119452879 small nuclear ribonucleoprotein F K11098 SNRPF; small nuclear ribonucleoprotein F
E 119455823 probable small nuclear ribonucleoprotein G K11099 SNRPG; small nuclear ribonucleoprotein G
C ELG1-RFC complex
D 119443114 replication factor C subunit 4-like K10755 RFC2_4; replication factor C subunit 2/4
D 119436753 replication factor C subunit 2 K10755 RFC2_4; replication factor C subunit 2/4
D 119446721 replication factor C subunit 5-like K10756 RFC3_5; replication factor C subunit 3/5
D 119449820 replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
C MRN complex
D 119453081 LOW QUALITY PROTEIN: double-strand break repair protein MRE11-like K10865 MRE11; double-strand break repair protein MRE11
D 119446041 DNA repair protein RAD50 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
D 119442616 nibrin K10867 NBN; nibrin
C Other termination factors
D 119461848 serine-protein kinase ATM K04728 ATM; serine-protein kinase ATM [EC:2.7.11.1]
D 119463363 Werner syndrome ATP-dependent helicase homolog K10900 WRN; werner syndrome ATP-dependent helicase [EC:5.6.2.4]
D 119453238 Bloom syndrome protein homolog K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
D 119433360 DNA repair endonuclease XPF-like K10848 ERCC4; DNA excision repair protein ERCC-4 [EC:3.1.-.-]
D 119464202 poly [ADP-ribose] polymerase 1 K24070 PARP1; poly [ADP-ribose] polymerase 1 [EC:2.4.2.30]
D 119431128 poly [ADP-ribose] polymerase 2 K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
D 119455818 poly [ADP-ribose] polymerase tankyrase-1 K10799 TNKS; tankyrase [EC:2.4.2.30]
D 119433436 G patch domain-containing protein 4 K11135 PINX1; Pin2-interacting protein X1
D 119461557 regulator of telomere elongation helicase 1 homolog K11136 RTEL1; regulator of telomere elongation helicase 1 [EC:5.6.2.3]
D 119446623 telomere length regulation protein TEL2 homolog K11137 TELO2; telomere length regulation protein
D 119433446 telomerase RNA component interacting RNase-like K01149 TRIR; telomerase RNA component interacting RNase [EC:3.1.13.-]
D 119434165 telomerase RNA component interacting RNase-like K01149 TRIR; telomerase RNA component interacting RNase [EC:3.1.13.-]
D 119441339 telomere-associated protein RIF1 isoform X1 K11138 RIF1; telomere-associated protein RIF1
D 119433774 ATP-dependent DNA helicase PIF1-like K15255 PIF1; ATP-dependent DNA helicase PIF1 [EC:5.6.2.3]
D 119433924 transcriptional activator protein Pur-beta-like isoform X2 K21772 PURA; transcriptional activator protein Pur-alpha
D 119441818 telomerase Cajal body protein 1 K23314 WRAP53; telomerase Cajal body protein 1
D 119441819 telomerase Cajal body protein 1 K23314 WRAP53; telomerase Cajal body protein 1
D 119431407 replication stress response regulator SDE2 K25059 SDE2; replication stress response regulator SDE2
D 119465951 replication termination factor 2 K25186 RTF2; replication termination factor 2
B DNA Topoisomerases
C 119453984 DNA topoisomerase 1 K03163 TOP1; DNA topoisomerase I [EC:5.6.2.1]
C 119436212 DNA topoisomerase I, mitochondrial-like K03163 TOP1; DNA topoisomerase I [EC:5.6.2.1]
C 119446008 DNA topoisomerase 2-alpha isoform X1 K03164 TOP2; DNA topoisomerase II [EC:5.6.2.2]
C 119434388 DNA topoisomerase 2-alpha K03164 TOP2; DNA topoisomerase II [EC:5.6.2.2]
C 119434489 DNA topoisomerase 2-alpha-like K03164 TOP2; DNA topoisomerase II [EC:5.6.2.2]
C 119455262 DNA topoisomerase 3-alpha-like isoform X1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
C 119464595 DNA topoisomerase 3-beta-1 isoform X1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
#
AProkaryotic type
B DNA Replication Initiation Factors
C Initiation factors (bacterial)
D 119436737 single-stranded DNA-binding protein, mitochondrial K03111 ssb; single-strand DNA-binding protein
C Initiation factors (archaeal)
B DNA Replication Elongation Factors
C Elongation factors (bacterial)
D DNA polymerase III holoenzyme
D RNase H
E 119431343 ribonuclease H1 K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
D Other elongation factors
C Elongation factors (archaeal)
D B-family DNA polymerases
D D-family DNA polymerases
D RNase H
E 119431343 ribonuclease H1 K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
D RFC (replication factor C)
D Other elongation factors
E 119446446 DNA replication ATP-dependent helicase/nuclease DNA2-like K10742 DNA2; DNA replication ATP-dependent helicase/nuclease Dna2 [EC:5.6.2.3 3.1.-.-]
E 119466142 flap endonuclease 1-B-like K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
E 119452831 DNA ligase 1-like isoform X1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
B DNA Replication Termination Factors
C Terminus site-binding protein
C DNA methylation enzymes
C Prevention of re-replication factors
B DNA Topoisomerases
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: November 2, 2022