+C Peptidases and inhibitors KO
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Peptidases and Inhibitors - Escherichia coli BL21(DE3)
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AAspartic peptidases
B Family A1: pepsin family
B Family A2: retropepsin family
B Family A5: thermopsin family
B Family A8: signal peptidase II family
C ECD_00031 lspA; prolipoprotein signal peptidase (signal peptidase II) K03101 lspA; signal peptidase II [EC:3.4.23.36]
B Family A22: presenilin family
B Family A24: type IV prepilin peptidase family
C ECD_02841 pppA; bifunctional prepilin leader peptidase/methylase K02654 pilD; leader peptidase (prepilin peptidase) / N-methyltransferase [EC:3.4.23.43 2.1.1.-]
C ECD_03186 gspO; bifunctional prepilin leader peptidase/methylase K02464 gspO; general secretion pathway protein O [EC:3.4.23.43 2.1.1.-]
B Family A25: gpr protease family
B Family A26: omptin family
B Family A28
B Family A31: HybD endopeptidase family
C ECD_00978 hyaD; hydrogenase 1 maturation protease K03605 hyaD; hydrogenase maturation protease [EC:3.4.23.-]
C ECD_02869 hybD; maturation protease for hydrogenase 2 K03605 hyaD; hydrogenase maturation protease [EC:3.4.23.-]
C ECD_02567 hycI; protease involved in processing C-terminal end of HycE K08315 hycI; hydrogenase 3 maturation protease [EC:3.4.23.51]
B Family A36
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ACysteine peptidases
B Family C1: papain family
B Family C2: calpain family
B Family C3: picornain family
B Family C4: NIa protease family
B Family C5
B Family C9
B Family C10: streptopain family
B Family C11: clostripain family
B Family C12: ubiquitin C-terminal hydrolase family
B Family C13: legumain family
B Family C14: caspase family
B Family C15: pyroglutamyl peptidase I family
B Family C16
B Family C19: ubiquitin-specific protease family
B Family C25: gingipain family
B Family C26: gamma-glutamyl hydrolase family
C ECD_02399 guaA; GMP synthetase (glutamine aminotransferase) K01951 guaA; GMP synthase (glutamine-hydrolysing) [EC:6.3.5.2]
C ECD_01275 puuD; gamma-glutamyl-gamma-aminobutyrate hydrolase K09473 puuD; gamma-glutamyl-gamma-aminobutyrate hydrolase [EC:3.5.1.94]
B Family C27
B Family C30
B Family C37
B Family C39
B Family C40
C ECD_02105 mepS; murein DD-endopeptidase, space-maker hydrolase, mutational suppressor of prc thermosensitivity, outer membrane lipoprotein, weak murein LD-carboxypeptidase K13694 mepS; murein DD-endopeptidase / murein LD-carboxypeptidase [EC:3.4.-.- 3.4.17.13]
C ECD_01625 mepH; murein DD-endopeptidase, space-maker hydrolase K19303 mepH; murein DD-endopeptidase [EC:3.4.-.-]
C ECD_01677 nlpC; putative C40 clan peptidase lipoprotein K13695 nlpC; probable lipoprotein NlpC
B Family C44
C ECD_02237 purF; amidophosphoribosyltransferase K00764 purF; amidophosphoribosyltransferase [EC:2.4.2.14]
C ECD_03077 gltB; glutamate synthase, large subunit K00265 gltB; glutamate synthase (NADPH) large chain [EC:1.4.1.13]
C ECD_03613 glmS; L-glutamine:D-fructose-6-phosphate aminotransferase K00820 glmS; glutamine---fructose-6-phosphate transaminase (isomerizing) [EC:2.6.1.16]
C ECD_00631 asnB; asparagine synthetase B K01953 asnB; asparagine synthase (glutamine-hydrolysing) [EC:6.3.5.4]
B Family C45
B Family C46: hedgehog family
B Family C47: staphopain family
B Family C48: Ulp1 endopeptidase family
B Family C50: separase family
B Family C54: Aut2 peptidase family
B Family C55: YopJ protease family
B Family C56: PfpI endopeptidase family
C ECD_01882 hchA; glyoxalase III and Hsp31 molecular chaperone K05523 hchA; D-lactate dehydratase / protein deglycase [EC:4.2.1.130 3.5.1.124]
C ECD_03020 yhbO; stress-resistance protein K05520 yhbO; deglycase [EC:3.5.1.124]
C ECD_00372 yajL; oxidative-stress-resistance chaperone K03152 thiJ; protein deglycase [EC:3.5.1.124]
B Family C57: vaccinia virus I7 peptidase family
B Family C58
B Family C59
B Family C60
B Family C63
B Family C64
B Family C65
B Family C67
B Family C69
B Family C70
B Family C75
B Family C76
B Family C78
B Family C79
C ECD_02196 elaD; protease, capable of cleaving an AMC-ubiquitin model substrate K18015 elaD; deubiquitinase [EC:3.4.22.-]
B Family C82
C ECD_01899 ldtA; L,D-transpeptidase linking Lpp to murein K16291 erfK; L,D-transpeptidase ErfK/SrfK
C ECD_01647 ldtE; murein L,D-transpeptidase K19234 ynhG; L,D-transpeptidase YnhG
C ECD_00786 ldtB; L,D-transpeptidase linking Lpp to murein K19235 ybiS; L,D-transpeptidase YbiS
C ECD_01109 ldtC; L,D-transpeptidase linking Lpp to murein K19236 ycfS; L,D-transpeptidase YcfS
C ECD_00929 ldtD; murein L,D-transpeptidase K21470 ycbB; L,D-transpeptidase YcbB
B Family C83
B Family C85
B Family C86
B Family C88
B Family C89
B Family C97
B Family C98
B Family C110
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AGlutamic peptidases
B Family G1
B Family G4
B Family G5: prenyl protease 2 family
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AMetallo peptidases
B Family M1
C ECD_00936 pepN; aminopeptidase N K01256 pepN; aminopeptidase N [EC:3.4.11.2]
B Family M2
B Family M3
C ECD_03347 prlC; oligopeptidase A K01414 prlC; oligopeptidase A [EC:3.4.24.70]
C ECD_01497 dcp; dipeptidyl carboxypeptidase II K01284 dcp; peptidyl-dipeptidase Dcp [EC:3.4.15.5]
B Family M4: thermolysin family
B Family M5: mycolysin family
B Family M6: immune inhibitor A family
B Family M7: snapalysin family
B Family M8: leishmanolysin family
B Family M9
B Family M10
B Family M12: astacin/adamalysin family
B Family M13: neprilysin family
B Family M14: carboxypeptidase A family
B Family M15: zinc D-Ala-D-Ala carboxypeptidase family
C ECD_01446 ddpX; D-ala-D-ala dipeptidase, Zn-dependent K08641 vanX; zinc D-Ala-D-Ala dipeptidase [EC:3.4.13.22]
B Family M16: pitrilysin family
C ECD_02669 ptrA; protease III K01407 ptrA; protease III [EC:3.4.24.55]
C ECD_01452 pqqL; putative periplasmic M16 family zinc metalloendopeptidase K07263 pqqL; zinc protease [EC:3.4.24.-]
B Family M17: leucyl aminopeptidase family
C ECD_04126 pepA; multifunctional aminopeptidase A: a cyteinylglycinase, transcription regulator and site-specific recombination factor K01255 CARP; leucyl aminopeptidase [EC:3.4.11.1]
C ECD_02415 pepB; aminopeptidase B K07751 pepB; PepB aminopeptidase [EC:3.4.11.23]
B Family M18
B Family M19: membrane dipeptidase family
B Family M20
C ECD_02363 dapE; N-succinyl-diaminopimelate deacylase K01439 dapE; succinyl-diaminopimelate desuccinylase [EC:3.5.1.18]
C ECD_01125 pepT; peptidase T K01258 pepT; tripeptide aminopeptidase [EC:3.4.11.4]
C ECD_00232 pepD; aminoacyl-histidine dipeptidase (peptidase D) K01270 pepD; dipeptidase D [EC:3.4.13.-]
C ECD_01315 abgA; p-aminobenzoyl-glutamate hydrolase, A subunit K12940 abgA; aminobenzoyl-glutamate utilization protein A
C ECD_01314 abgB; p-aminobenzoyl-glutamate hydrolase, B subunit K12941 abgB; aminobenzoyl-glutamate utilization protein B
C ECD_00466 allC; allantoate amidohydrolase K02083 allC; allantoate deiminase [EC:3.5.3.9]
B Family M23
C ECD_01827 mepM; murein DD-endopeptidase, space-maker hydrolase, septation protein K19304 mepM; murein DD-endopeptidase [EC:3.4.24.-]
B Family M24
C ECD_00166 map; methionine aminopeptidase K01265 map; methionyl aminopeptidase [EC:3.4.11.18]
C ECD_03738 pepQ; proline dipeptidase K01271 pepQ; Xaa-Pro dipeptidase [EC:3.4.13.9]
C ECD_02740 pepP; proline aminopeptidase P II K01262 pepP; Xaa-Pro aminopeptidase [EC:3.4.11.9]
C ECD_02295 ypdF; Xaa-Pro aminopeptidase K08326 ypdF; aminopeptidase [EC:3.4.11.-]
B Family M26
B Family M27
B Family M28: aminopeptidase Y family
C ECD_02603 iap; aminopeptidase in alkaline phosphatase isozyme conversion K09612 iap; alkaline phosphatase isozyme conversion protein [EC:3.4.11.-]
B Family M29: aminopeptidase T family
B Family M32: carboxypeptidase Taq family
B Family M34: anthrax lethal factor family
B Family M35: deuterolysin family
B Family M36: fungalysin family
B Family M38: beta-aspartyl dipeptidase family
C ECD_04197 iadA; isoaspartyl dipeptidase K01305 iadA; beta-aspartyl-dipeptidase (metallo-type) [EC:3.4.19.-]
B Family M41: FtsH endopeptidase family
C ECD_03043 ftsH; protease, ATP-dependent zinc-metallo K03798 ftsH; cell division protease FtsH [EC:3.4.24.-]
B Family M42: glutamyl aminopeptidase family
C ECD_03783 frvX; putative peptidase K18530 frvX; putative aminopeptidase FrvX [EC:3.4.11.-]
C ECD_04171 sgcX; putative endoglucanase with Zn-dependent exopeptidase domain K20609 sgcX; putative aminopeptidase [EC:3.4.11.-]
B Family M43: cytophagalysin family
B Family M44
B Family M48: Ste24 endopeptidase family
C ECD_01800 htpX; putative endopeptidase K03799 htpX; heat shock protein HtpX [EC:3.4.24.-]
C ECD_00913 ycaL; putative peptidase-related chaperone K07387 K07387; metalloprotease [EC:3.4.24.-]
C ECD_02766 loiP; Phe-Phe periplasmic metalloprotease, OM lipoprotein; low salt-inducible; Era-binding heat shock protein K07387 K07387; metalloprotease [EC:3.4.24.-]
C ECD_02386 bepA; OM protein maintenance and assembly metalloprotease and chaperone, periplasmic K01423 bepA; beta-barrel assembly-enhancing protease [EC:3.4.-.-]
B Family M49: dipeptidyl-peptidase III family
B Family M50: S2P protease family
C ECD_00174 rseP; inner membrane zinc RIP metalloprotease; RpoE activator, by degrading RseA; cleaved signal peptide endoprotease K11749 rseP; regulator of sigma E protease [EC:3.4.24.-]
B Family M54
B Family M55: DppA aminopeptidase family
B Family M56
B Family M67
B Family M72
B Family M73
B Family M74
C ECD_02253 mepA; murein DD-endopeptidase K07261 mepA; penicillin-insensitive murein DD-endopeptidase [EC:3.4.24.-]
B Family M80
B Family M82
B Family M85
B Family M88
B Family M90
C ECD_01890 mtfA; anti-repressor for DgsA(Mlc) K09933 mtfA; MtfA peptidase
B Family M98
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AAsparagine peptide lyases
B Family N1
B Family N8
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AMixed peptidases
B Family P1: DmpA aminopeptidase family
B Family P2
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ASerine peptidases
B Family S1: chymotrypsin family
C ECD_01567 ydgD; putative peptidase K04775 ydgD; protease YdgD [EC:3.4.21.-]
C ECD_00160 degP; serine endoprotease (protease Do), membrane-associated K04771 degP; serine protease Do [EC:3.4.21.107]
C ECD_03094 degQ; serine endoprotease, periplasmic K04772 degQ; serine protease DegQ [EC:3.4.21.-]
C ECD_03095 degS; serine endoprotease, periplasmic K04691 hhoB; serine protease DegS [EC:3.4.21.-]
B Family S3: togavirin family
B Family S6
B Family S7: flavivirin family
B Family S8: subtilisin family
B Family S9: prolyl oligopeptidase family
C ECD_01816 ptrB; protease II K01354 ptrB; oligopeptidase B [EC:3.4.21.83]
B Family S10
B Family S11: D-Ala-D-Ala carboxypeptidase A family
C ECD_00601 dacA; D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 5) K07258 dacC; serine-type D-Ala-D-Ala carboxypeptidase (penicillin-binding protein 5/6) [EC:3.4.16.4]
C ECD_00806 dacC; D-alanyl-D-alanine carboxypeptidase; penicillin-binding protein 6a K07258 dacC; serine-type D-Ala-D-Ala carboxypeptidase (penicillin-binding protein 5/6) [EC:3.4.16.4]
C ECD_01913 dacD; D-alanyl-D-alanine carboxypeptidase; penicillin-binding protein 6b K07258 dacC; serine-type D-Ala-D-Ala carboxypeptidase (penicillin-binding protein 5/6) [EC:3.4.16.4]
C ECD_02064 pbpG; D-alanyl-D-alanine endopeptidase K07262 pbpG; serine-type D-Ala-D-Ala endopeptidase (penicillin-binding protein 7) [EC:3.4.21.-]
B Family S12: D-Ala-D-Ala carboxypeptidase B family
C ECD_00323 ampH; D-alanyl-D-alanine-carboxypeptidase/endopeptidase; penicillin-binding protein; weak beta-lactamase K18988 ampH; serine-type D-Ala-D-Ala carboxypeptidase/endopeptidase [EC:3.4.16.4 3.4.21.-]
B Family S13: D-Ala-D-Ala peptidase C family
C ECD_03047 dacB; D-alanyl-D-alanine carboxypeptidase K07259 dacB; serine-type D-Ala-D-Ala carboxypeptidase/endopeptidase (penicillin-binding protein 4) [EC:3.4.16.4 3.4.21.-]
B Family S14: ClpP endopeptidase family
C ECD_00388 clpP; proteolytic subunit of ClpA-ClpP and ClpX-ClpP ATP-dependent serine proteases K01358 clpP; ATP-dependent Clp protease, protease subunit [EC:3.4.21.92]
B Family S15
B Family S16: lon protease family
C ECD_00391 lon; DNA-binding ATP-dependent protease La K01338 lon; ATP-dependent Lon protease [EC:3.4.21.53]
C ECD_00959 ycbZ; putative peptidase K04770 lonH; Lon-like ATP-dependent protease [EC:3.4.21.-]
B Family S21: assemblin family
B Family S24: LexA family
C ECD_03915 lexA; transcriptional repressor of SOS regulon K01356 lexA; repressor LexA [EC:3.4.21.88]
C ECD_01158 umuD; translesion error-prone DNA polymerase V subunit; RecA-activated auto-protease K03503 umuD; DNA polymerase V [EC:3.4.21.-]
B Family S26: signal peptidase I family
C ECD_02462 lepB; leader peptidase (signal peptidase I) K03100 lepB; signal peptidase I [EC:3.4.21.89]
B Family S28
B Family S31
B Family S32
B Family S33
B Family S41: C-terminal processing peptidase family
C ECD_01801 prc; carboxy-terminal protease for penicillin-binding protein 3 K03797 E3.4.21.102; carboxyl-terminal processing protease [EC:3.4.21.102]
B Family S45
B Family S49: protease IV family
C ECD_01735 sppA; protease IV (signal peptide peptidase) K04773 sppA; protease IV [EC:3.4.21.-]
C ECD_01248 sohB; inner membrane protein, S49 peptidase family protein K04774 sohB; serine protease SohB [EC:3.4.21.-]
C ECD_10039 C; capsid component K21511 C; Enterobacteria phage capsid assembly protease [EC:3.4.21.-]
B Family S50
B Family S51
C ECD_03893 pepE; peptidase E, alpha-aspartyl dipeptidase K05995 pepE; dipeptidase E [EC:3.4.13.21]
B Family S53
B Family S54: Rhomboid family
C ECD_03275 glpG; rhomboid intramembrane serine protease K02441 glpG; rhomboid protease GlpG [EC:3.4.21.105]
B Family S55: SpoIVB peptidase family
B Family S62
B Family S66
C ECD_01167 ldcA; murein tetrapeptide carboxypeptidase; LD-carboxypeptidase A K01297 ldcA; muramoyltetrapeptide carboxypeptidase [EC:3.4.17.13]
B Family S77: phage prohead processing peptidase family
B Family S78
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AThreonine peptidases
B Family T1: proteasome family
C ECD_03817 hslV; peptidase component of the HslUV protease K01419 hslV; ATP-dependent HslUV protease, peptidase subunit HslV [EC:3.4.25.2]
B Family T2
C ECD_00795 iaaA; Isoaspartyl peptidase K13051 ASRGL1; L-asparaginase / beta-aspartyl-peptidase [EC:3.5.1.1 3.4.19.5]
B Family T3: gamma-glutamyltransferase family
C ECD_03296 ggt; gamma-glutamyltranspeptidase K00681 ggt; gamma-glutamyltranspeptidase / glutathione hydrolase [EC:2.3.2.2 3.4.19.13]
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APeptidases of unknown catalytic type
B Family U32
C ECD_01986 yegQ; putative peptidase K08303 prtC; U32 family peptidase [EC:3.4.-.-]
C ECD_01393 ydcP; putative peptidase K24847 rlhA; 23S rRNA 5-hydroxycytidine C2501 synthase
C ECD_03026 yhbV; U32 peptidase family protein K24845 ubiV; 2-(all-trans-polyprenyl)phenol 6-hydroxylase (prephenate) UbiV [EC:1.97.1.15]
C ECD_03025 yhbU; U32 peptidase family protein K24844 ubiU; 2-(all-trans-polyprenyl)phenol 6-hydroxylase (prephenate) UbiU [EC:1.97.1.15]
B Family U62
C ECD_04103 pmbA; putative antibiotic peptide MccB17 maturation peptidase K03592 pmbA; PmbA protein
C ECD_03104 tldD; putative peptidase K03568 tldD; TldD protein
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APeptidase inhibitors
B Family I1: Kazal family
B Family I2: Kunitz - BPTI family
B Family I4: serpin family
B Family I11: ecotin family
C ECD_02136 eco; ecotin, a serine protease inhibitor K08276 eco; ecotin
B Family I17: WAP-type family
B Family I25: cystatin family
B Family I27: calpastatin family
B Family I32: IAP family
B Family I34: IA3 family
B Family I35: timp family
B Family I39: alpha2M family
C ECD_02154 yfaS; putative membrane protein K06894 yfhM; alpha-2-macroglobulin
C ECD_02412 yfhM; bacterial alpha2-macroglobulin colonization factor ECAM; anti-host protease defense factor; periplasmic inner membrane-anchored lipoprotein K06894 yfhM; alpha-2-macroglobulin
B Family I47: latexin family
B Family I49: proSAAS family
B Family I51: IC family
B Family I57: staphostatin B family
B Family I63
B Family I80
B Family I87
C ECD_04042 hflC; HflB protease modulator specific for phage lambda cII repressor K04087 hflC; modulator of FtsH protease HflC
C ECD_04041 hflK; modulator for HflB protease specific for phage lambda cII repressor K04088 hflK; modulator of FtsH protease HflK
B Family I93
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: June 20, 2025
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Classification taken and modified from MEROPS