+F Repair protein KO
#
DNA Repair and Recombination Proteins - Equus caballus (horse)
%
!
AEukaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D 100049801 MGMT; methylated-DNA--protein-cysteine methyltransferase isoform X5 K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
D 100059785 ALKBH2; DNA oxidative demethylase ALKBH2 K10859 ALKBH2; DNA oxidative demethylase [EC:1.14.11.33]
D 100055568 ALKBH3; alpha-ketoglutarate-dependent dioxygenase alkB homolog 3 isoform X1 K10860 ALKBH3; mRNA N1-methyladenine demethylase [EC:1.14.11.54]
D 100066202 ASCC3; activating signal cointegrator 1 complex subunit 3 isoform X1 K18663 ASCC3; activating signal cointegrator complex subunit 3 [EC:5.6.2.4]
C BER (base exicision repair)
D DNA glycosylases
E 100059759 UNG; uracil-DNA glycosylase K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E 100147250 CCNO; cyclin-O K10861 UDG2; uracil-DNA glycosylase 2 [EC:3.2.2.-]
E 100053458 TDG; G/T mismatch-specific thymine DNA glycosylase isoform X1 K20813 TDG; thymine-DNA glycosylase [EC:3.2.2.29]
E 100065027 MPG; DNA-3-methyladenine glycosylase K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]
E 100064502 SMUG1; single-strand selective monofunctional uracil DNA glycosylase K10800 SMUG1; single-strand selective monofunctional uracil DNA glycosylase [EC:3.2.2.-]
E 100056679 MBD4; methyl-CpG-binding domain protein 4 isoform X1 K10801 MBD4; methyl-CpG-binding domain protein 4 [EC:3.2.2.-]
E 100058398 OGG1; N-glycosylase/DNA lyase isoform X2 K03660 OGG1; N-glycosylase/DNA lyase [EC:3.2.2.- 4.2.99.18]
E 100061643 NEIL1; endonuclease 8-like 1 isoform X1 K10567 NEIL1; endonuclease VIII-like 1 [EC:3.2.2.- 4.2.99.18]
E 100065246 NEIL2; endonuclease 8-like 2 isoform X1 K10568 NEIL2; endonuclease VIII-like 2 [EC:3.2.2.- 4.2.99.18]
E 100060702 NEIL3; endonuclease 8-like 3 isoform X1 K10569 NEIL3; endonuclease VIII-like 3 [EC:3.2.2.- 4.2.99.18]
E 100065659 NTHL1; endonuclease III-like protein 1 isoform X1 K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
E 100072588 APEX1; DNA-(apurinic or apyrimidinic site) lyase isoform X2 K10771 APEX1; AP endonuclease 1 [EC:3.1.11.2]
E 100062550 APEX2; DNA-(apurinic or apyrimidinic site) lyase 2 K10772 APEX2; AP endonuclease 2 [EC:3.1.11.2]
D Long Patch-BER factors
E DNA polymerase delta complex
F 100052455 POLD1; DNA polymerase delta catalytic subunit K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
F 100147367 POLD2; DNA polymerase delta subunit 2 K02328 POLD2; DNA polymerase delta subunit 2
F 100051966 POLD3; DNA polymerase delta subunit 3 K03504 POLD3; DNA polymerase delta subunit 3
F 100059111 POLD4; DNA polymerase delta subunit 4 isoform X2 K03505 POLD4; DNA polymerase delta subunit 4
E DNA polymerase epsilon complex
F 100061669 POLE; DNA polymerase epsilon catalytic subunit A isoform X2 K02324 POLE; DNA polymerase epsilon subunit 1 [EC:2.7.7.7]
F 100065785 POLE2; DNA polymerase epsilon subunit 2 isoform X1 K02325 POLE2; DNA polymerase epsilon subunit 2 [EC:2.7.7.7]
F 100050165 POLE3; DNA polymerase epsilon subunit 3 K02326 POLE3; DNA polymerase epsilon subunit 3 [EC:2.7.7.7]
F 100068933 POLE4; DNA polymerase epsilon subunit 4 K03506 POLE4; DNA polymerase epsilon subunit 4 [EC:2.7.7.7]
E 100052065 PCNA; proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
E 100059838 FEN1; flap endonuclease 1 K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
E 100053186 LIG1; DNA ligase 1 isoform X1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
D Short Patch-BER factors
E 100050102 POLB; DNA polymerase beta K02330 POLB; DNA polymerase beta [EC:2.7.7.7 4.2.99.-]
E 100070201 XRCC1; DNA repair protein XRCC1 isoform X1 K10803 XRCC1; DNA-repair protein XRCC1
E 100071671 LIG3; DNA ligase 3 isoform X3 K10776 LIG3; DNA ligase 3 [EC:6.5.1.1]
D Other BER factors
E 100062463 TDP1; tyrosyl-DNA phosphodiesterase 1 isoform X2 K10862 TDP1; tyrosyl-DNA phosphodiesterase 1 [EC:3.1.4.-]
E 100068091 APTX; aprataxin isoform X1 K10863 APTX; aprataxin [EC:3.6.1.70 3.6.1.71 3.6.1.72]
E 100061683 APLF; aprataxin and PNK-like factor K13295 APLF; aprataxin and PNK-like factor [EC:3.1.-.-]
E 100052218 PNKP; bifunctional polynucleotide phosphatase/kinase K08073 PNKP; bifunctional polynucleotide phosphatase/kinase [EC:3.1.3.32 2.7.1.78]
E 100033873 HMGB1; high mobility group protein B1 K10802 HMGB1; high mobility group protein B1
E 100070125 POLL; DNA polymerase lambda isoform X1 K03512 POLL; DNA polymerase lambda [EC:2.7.7.7 4.2.99.-]
E 100058523 PARP1; poly [ADP-ribose] polymerase 1 K24070 PARP1; poly [ADP-ribose] polymerase 1 [EC:2.4.2.30]
E 100072572 PARP2; poly [ADP-ribose] polymerase 2 isoform X1 K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
E 100053202 PARP4; poly [ADP-ribose] polymerase 4 isoform X1 K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
E 100060729 PARP3; poly [ADP-ribose] polymerase 3 K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E XPC-HR23B-CETN2 complex
F 100050424 XPC; DNA repair protein complementing XP-C cells isoform X1 K10838 XPC; xeroderma pigmentosum group C-complementing protein
F 100146594 RAD23A; UV excision repair protein RAD23 homolog A isoform X1 K10839 RAD23; UV excision repair protein RAD23
F 100059968 RAD23B; UV excision repair protein RAD23 homolog B K10839 RAD23; UV excision repair protein RAD23
F 111772206 UV excision repair protein RAD23 homolog B K10839 RAD23; UV excision repair protein RAD23
F 111767493 UV excision repair protein RAD23 homolog B-like K10839 RAD23; UV excision repair protein RAD23
F 100063613 CETN2; centrin-2 K10840 CETN2; centrin-2
E Cul4-DDB2 complex
F 100055581 RBX1; E3 ubiquitin-protein ligase RBX1 isoform X1 K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
F 100033930 CUL4A; cullin-4A K10609 CUL4; cullin 4
F 100033938 CUL4B; cullin-4B isoform X3 K10609 CUL4; cullin 4
F 100059606 DDB1; DNA damage-binding protein 1 K10610 DDB1; DNA damage-binding protein 1
F 100051180 DDB2; DNA damage-binding protein 2 isoform X1 K10140 DDB2; DNA damage-binding protein 2
E NER4 complex
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase II complex
F 100072997 POLR2A; DNA-directed RNA polymerase II subunit RPB1 K03006 RPB1; DNA-directed RNA polymerase II subunit RPB1 [EC:2.7.7.6]
F 100053708 POLR2B; DNA-directed RNA polymerase II subunit RPB2 K03010 RPB2; DNA-directed RNA polymerase II subunit RPB2 [EC:2.7.7.6]
F 100052195 POLR2C; DNA-directed RNA polymerase II subunit RPB3 K03011 RPB3; DNA-directed RNA polymerase II subunit RPB3
F 100069214 POLR2D; DNA-directed RNA polymerase II subunit RPB4 K03012 RPB4; DNA-directed RNA polymerase II subunit RPB4
F 100065431 POLR2E; DNA-directed RNA polymerases I, II, and III subunit RPABC1 K03013 RPABC1; DNA-directed RNA polymerases I, II, and III subunit RPABC1
F 100054935 POLR2F; DNA-directed RNA polymerases I, II, and III subunit RPABC2 K03014 RPABC2; DNA-directed RNA polymerases I, II, and III subunit RPABC2
F 100063883 POLR2G; DNA-directed RNA polymerase II subunit RPB7 K03015 RPB7; DNA-directed RNA polymerase II subunit RPB7
F 100059115 POLR2H; DNA-directed RNA polymerases I, II, and III subunit RPABC3 K03016 RPABC3; DNA-directed RNA polymerases I, II, and III subunit RPABC3
F 100051926 POLR2I; DNA-directed RNA polymerase II subunit RPB9 K03017 RPB9; DNA-directed RNA polymerase II subunit RPB9
F 100629865 POLR2L; DNA-directed RNA polymerases I, II, and III subunit RPABC5 K03007 RPABC5; DNA-directed RNA polymerases I, II, and III subunit RPABC5
F 111776015 POLR2L; DNA-directed RNA polymerases I, II, and III subunit RPABC5 K03007 RPABC5; DNA-directed RNA polymerases I, II, and III subunit RPABC5
F 100059695 POLR2J; DNA-directed RNA polymerase II subunit RPB11-a K03008 RPB11; DNA-directed RNA polymerase II subunit RPB11
F 100630612 POLR2K; DNA-directed RNA polymerases I, II, and III subunit RPABC4 K03009 RPABC4; DNA-directed RNA polymerases I, II, and III subunit RPABC4
E Cul4-CSA complex
F 100055581 RBX1; E3 ubiquitin-protein ligase RBX1 isoform X1 K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
F 100033930 CUL4A; cullin-4A K10609 CUL4; cullin 4
F 100033938 CUL4B; cullin-4B isoform X3 K10609 CUL4; cullin 4
F 100059606 DDB1; DNA damage-binding protein 1 K10610 DDB1; DNA damage-binding protein 1
F 100051199 ERCC8; DNA excision repair protein ERCC-8 isoform X1 K10570 ERCC8; DNA excision repair protein ERCC-8
E Other TCR factor
F 100062916 ERCC6; DNA excision repair protein ERCC-6 isoform X1 K10841 ERCC6; DNA excision repair protein ERCC-6
F 100052397 UVSSA; UV-stimulated scaffold protein A K23720 UVSSA; UV-stimulated scaffold protein A
F 100056704 ELOF1; transcription elongation factor 1 homolog K25829 ELOF1; transcription elongation factor 1
D TFIIH complex
E 100050708 ERCC3; TFIIH basal transcription factor complex helicase XPB subunit isoform X1 K10843 ERCC3; DNA excision repair protein ERCC-3 [EC:5.6.2.4]
E 100070804 ERCC2; TFIIH basal transcription factor complex helicase XPD subunit K10844 ERCC2; DNA excision repair protein ERCC-2 [EC:5.6.2.3]
E 100056980 GTF2H1; general transcription factor IIH subunit 1 K03141 TFIIH1; transcription initiation factor TFIIH subunit 1
E 100073305 general transcription factor IIH subunit 2 K03142 TFIIH2; transcription initiation factor TFIIH subunit 2
E 100059174 GTF2H3; general transcription factor IIH subunit 3 K03143 TFIIH3; transcription initiation factor TFIIH subunit 3
E 100630479 GTF2H4; general transcription factor IIH subunit 4 K03144 TFIIH4; transcription initiation factor TFIIH subunit 4
E 111771414 GTF2H5; general transcription factor IIH subunit 5 K10845 TTDA; TFIIH basal transcription factor complex TTD-A subunit
E 100049964 CDK7; cyclin-dependent kinase 7 isoform X1 K02202 CDK7; cyclin-dependent kinase 7 [EC:2.7.11.22 2.7.11.23]
E 100065185 CCNH; cyclin-H isoform X1 K06634 CCNH; cyclin H
E 100051488 MNAT1; CDK-activating kinase assembly factor MAT1 isoform X2 K10842 MNAT1; CDK-activating kinase assembly factor MAT1
D RPA (replication factor A)
E 100072427 RPA1; replication protein A 70 kDa DNA-binding subunit K07466 RFA1; replication factor A1
E 100070826 RPA2; replication protein A 32 kDa subunit K10739 RFA2; replication factor A2
E 100063929 RPA3; replication protein A 14 kDa subunit K10740 RPA3; replication factor A3
E 100057104 RPA4; replication protein A 30 kDa subunit K10741 RPA4; replication factor A4
D Other NER factors
E 100064497 XPA; DNA repair protein complementing XP-A cells isoform X1 K10847 XPA; DNA-repair protein complementing XP-A cells
E 100065660 ERCC1; DNA excision repair protein ERCC-1 K10849 ERCC1; DNA excision repair protein ERCC-1
E 100050812 ERCC4; DNA repair endonuclease XPF K10848 ERCC4; DNA excision repair protein ERCC-4 [EC:3.1.-.-]
E 102147743 DNA repair protein complementing XP-G cells isoform X1 K10846 ERCC5; DNA excision repair protein ERCC-5
E 100053186 LIG1; DNA ligase 1 isoform X1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
E 100070717 MMS19; MMS19 nucleotide excision repair protein homolog isoform X1 K15075 MET18; DNA repair/transcription protein MET18/MMS19
E 100061420 CUL3; cullin-3 isoform X1 K03869 CUL3; cullin 3
E 100061726 CUL5; cullin-5 K10612 CUL5; cullin 5
E 100060902 ELOC; elongin-C K03872 ELOC; elongin-C
E 106781563 ELOB; elongin-B isoform X1 K03873 ELOB; elongin-B
E 100071575 ELOA; transcription elongation factor B polypeptide 3 K15076 ELOA; elongin-A
E 111772416 ELOA; elongin-A isoform X1 K15076 ELOA; elongin-A
E 100056822 UBAP2L; ubiquitin-associated protein 2-like isoform X1 K26545 UBAP2; ubiquitin-associated protein 2
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
E 100068146 MSH2; DNA mismatch repair protein Msh2 K08735 MSH2; DNA mismatch repair protein MSH2
E 100073255 MSH3; DNA mismatch repair protein Msh3 K08736 MSH3; DNA mismatch repair protein MSH3
E 100068065 MSH6; DNA mismatch repair protein Msh6 isoform X1 K08737 MSH6; DNA mismatch repair protein MSH6
D MutL homologs
E 100054470 PMS1; PMS1 protein homolog 1 isoform X4 K10864 PMS1; DNA mismatch repair protein PMS1
E 100050351 MLH1; DNA mismatch repair protein Mlh1 isoform X1 K08734 MLH1; DNA mismatch repair protein MLH1
E 100062380 PMS2; mismatch repair endonuclease PMS2 isoform X1 K10858 PMS2; DNA mismatch repair protein PMS2
E 100057292 MLH3; DNA mismatch repair protein Mlh3 isoform X1 K08739 MLH3; DNA mismatch repair protein MLH3
D DNA polymerase delta complex
E 100052455 POLD1; DNA polymerase delta catalytic subunit K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
E 100147367 POLD2; DNA polymerase delta subunit 2 K02328 POLD2; DNA polymerase delta subunit 2
E 100051966 POLD3; DNA polymerase delta subunit 3 K03504 POLD3; DNA polymerase delta subunit 3
E 100059111 POLD4; DNA polymerase delta subunit 4 isoform X2 K03505 POLD4; DNA polymerase delta subunit 4
D RPA (replication factor A)
E 100072427 RPA1; replication protein A 70 kDa DNA-binding subunit K07466 RFA1; replication factor A1
E 100070826 RPA2; replication protein A 32 kDa subunit K10739 RFA2; replication factor A2
E 100063929 RPA3; replication protein A 14 kDa subunit K10740 RPA3; replication factor A3
E 100057104 RPA4; replication protein A 30 kDa subunit K10741 RPA4; replication factor A4
D RFC (replication factor C)
E 100064382 RFC1; replication factor C subunit 1 isoform X1 K10754 RFC1; replication factor C subunit 1
E 100068189 RFC4; replication factor C subunit 4 K10755 RFC2_4; replication factor C subunit 2/4
E 100059980 RFC2; replication factor C subunit 2 isoform X2 K10755 RFC2_4; replication factor C subunit 2/4
E 100062326 RFC3; replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
E 100054946 RFC5; replication factor C subunit 5 K10756 RFC3_5; replication factor C subunit 3/5
D Other MMR factors
E 100052065 PCNA; proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
E 100054824 EXO1; exonuclease 1 isoform X1 K10746 EXO1; exonuclease 1 [EC:3.1.-.-]
E 100033873 HMGB1; high mobility group protein B1 K10802 HMGB1; high mobility group protein B1
E 100053186 LIG1; DNA ligase 1 isoform X1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
E 100070718 WDR76; WD repeat-containing protein 76 isoform X1 K24755 WDR76; WD repeat-containing protein 76
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D MRN(MRX) complex
E 100060936 MRE11; double-strand break repair protein MRE11 isoform X2 K10865 MRE11; double-strand break repair protein MRE11
E 100063198 RAD50; DNA repair protein RAD50 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
E 100050939 NBN; nibrin isoform X1 K10867 NBN; nibrin
D BRCA1-core complex
E 100051990 BRCA1; breast cancer type 1 susceptibility protein isoform X4 K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 100053962 BARD1; BRCA1-associated RING domain protein 1 K10683 BARD1; BRCA1-associated RING domain protein 1
D BRCA1-A complex
E 100051990 BRCA1; breast cancer type 1 susceptibility protein isoform X4 K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 100061483 ABRAXAS1; BRCA1-A complex subunit Abraxas 1 isoform X1 K20774 FAM175A; BRCA1-A complex subunit Abraxas
E 100058611 UIMC1; BRCA1-A complex subunit RAP80 isoform X1 K20775 UIMC1; BRCA1-A complex subunit RAP80
E 100069531 BABAM1; BRISC and BRCA1-A complex member 1 isoform X2 K20776 BABAM; BRISC and BRCA1-A complex member 1
E 100054872 BABAM2; BRISC and BRCA1-A complex member 2 K12173 BRE; BRCA1-A complex subunit BRE
E 100062237 BRCC3; lys-63-specific deubiquitinase BRCC36 isoform X1 K11864 BRCC3; BRCA1/BRCA2-containing complex subunit 3 [EC:3.4.19.-]
D BRCA1-B complex
E 100051990 BRCA1; breast cancer type 1 susceptibility protein isoform X4 K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 100071185 BRIP1; Fanconi anemia group J protein K15362 BRIP1; fanconi anemia group J protein [EC:5.6.2.3]
E 100053011 TOPBP1; DNA topoisomerase 2-binding protein 1 isoform X1 K10728 TOPBP1; topoisomerase (DNA) II binding protein 1
D BRCA1-C complex
E 100051990 BRCA1; breast cancer type 1 susceptibility protein isoform X4 K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 100050857 RBBP8; DNA endonuclease RBBP8 isoform X1 K20773 RBBP8; DNA endonuclease RBBP8 [EC:3.1.-.-]
E 111771549 uncharacterized protein LOC111771549 K20773 RBBP8; DNA endonuclease RBBP8 [EC:3.1.-.-]
E 100060936 MRE11; double-strand break repair protein MRE11 isoform X2 K10865 MRE11; double-strand break repair protein MRE11
E 100063198 RAD50; DNA repair protein RAD50 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
E 100050939 NBN; nibrin isoform X1 K10867 NBN; nibrin
D BRCA complex
E 100051990 BRCA1; breast cancer type 1 susceptibility protein isoform X4 K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 100064578 BRCA2; breast cancer type 2 susceptibility protein isoform X1 K08775 BRCA2; breast cancer 2 susceptibility protein
E 100069097 PALB2; partner and localizer of BRCA2 isoform X1 K10897 PALB2; partner and localizer of BRCA2
E 100071340 RAD51; DNA repair protein RAD51 homolog 1 K04482 RAD51; DNA repair protein RAD51
D RecA family proteins
E 100071340 RAD51; DNA repair protein RAD51 homolog 1 K04482 RAD51; DNA repair protein RAD51
E 100053023 RAD51B; DNA repair protein RAD51 homolog 2 isoform X1 K10869 RAD51L1; RAD51-like protein 1
E 100070966 RAD51C; DNA repair protein RAD51 homolog 3 K10870 RAD51L2; RAD51-like protein 2
E 100071664 RAD51D; DNA repair protein RAD51 homolog 4 isoform X1 K10871 RAD51L3; RAD51-like protein 3
E 100065014 XRCC2; DNA repair protein XRCC2 K10879 XRCC2; DNA-repair protein XRCC2
E 102148799 XRCC3; DNA repair protein XRCC3 isoform X1 K10880 XRCC3; DNA-repair protein XRCC3
D Rad52 family proteins
E 100050254 RAD52; DNA repair protein RAD52 homolog isoform X3 K10873 RAD52; DNA repair and recombination protein RAD52
E 100063820 RDM1; RAD52 motif-containing protein 1 isoform X2 K10874 RDM1; RAD52 motif-containing protein 1
D Rad54 family proteins
E 100064782 RAD54L; DNA repair and recombination protein RAD54-like K10875 RAD54L; DNA repair and recombination protein RAD54 and RAD54-like protein [EC:5.6.2.-]
E 100052240 RAD54L2; helicase ARIP4 isoform X1 K10876 RAD54L2; RAD54-like protein 2 [EC:5.6.2.-]
E 100146782 RAD54B; DNA repair and recombination protein RAD54B isoform X1 K10877 RAD54B; DNA repair and recombination protein RAD54B [EC:5.6.2.-]
D RecQ family DNA helicases
E 100068195 RECQL; ATP-dependent DNA helicase Q1 isoform X1 K10899 RECQL; ATP-dependent DNA helicase Q1 [EC:5.6.2.4]
E 100062021 WRN; Werner syndrome ATP-dependent helicase isoform X2 K10900 WRN; werner syndrome ATP-dependent helicase [EC:5.6.2.4]
E 100064627 RECQL4; ATP-dependent DNA helicase Q4 K10730 RECQL4; ATP-dependent DNA helicase Q4 [EC:5.6.2.4]
E 100059566 RECQL5; ATP-dependent DNA helicase Q5 isoform X1 K10902 RECQL5; ATP-dependent DNA helicase Q5 [EC:5.6.2.4]
D Bloom's syndrome complex (BTR)
E 100051666 TOP3A; DNA topoisomerase 3-alpha isoform X1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 100051153 TOP3B; DNA topoisomerase 3-beta-1 isoform X1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 100052791 RMI1; recQ-mediated genome instability protein 1 K10990 RMI1; RecQ-mediated genome instability protein 1
E 111767564 RMI2; recQ-mediated genome instability protein 2 K15365 RMI2; RecQ-mediated genome instability protein 2
D RPA (replication factor A)
E 100072427 RPA1; replication protein A 70 kDa DNA-binding subunit K07466 RFA1; replication factor A1
E 100070826 RPA2; replication protein A 32 kDa subunit K10739 RFA2; replication factor A2
E 100063929 RPA3; replication protein A 14 kDa subunit K10740 RPA3; replication factor A3
E 100057104 RPA4; replication protein A 30 kDa subunit K10741 RPA4; replication factor A4
D Protein phosphatase 4
E 100064118 PPP4C; serine/threonine-protein phosphatase 4 catalytic subunit K15423 PPP4C; serine/threonine-protein phosphatase 4 catalytic subunit [EC:3.1.3.16]
E 100055125 PPP4R1; serine/threonine-protein phosphatase 4 regulatory subunit 1 isoform X1 K15424 PPP4R1; serine/threonine-protein phosphatase 4 regulatory subunit 1
E 100056167 serine/threonine-protein phosphatase 4 regulatory subunit 1 isoform X5 K15424 PPP4R1; serine/threonine-protein phosphatase 4 regulatory subunit 1
E 100061905 PPP4R2; serine/threonine-protein phosphatase 4 regulatory subunit 2 isoform X2 K15425 PPP4R2; serine/threonine-protein phosphatase 4 regulatory subunit 2
E 100061897 serine/threonine-protein phosphatase 4 regulatory subunit 3B K17491 SMEK; protein phosphatase 4 regulatory subunit 3
E 100063171 PPP4R3A; serine/threonine-protein phosphatase 4 regulatory subunit 3A isoform X1 K17491 SMEK; protein phosphatase 4 regulatory subunit 3
E 100066287 PPP4R3B; serine/threonine-protein phosphatase 4 regulatory subunit 3B isoform X1 K17491 SMEK; protein phosphatase 4 regulatory subunit 3
E 100064914 PPP4R4; serine/threonine-protein phosphatase 4 regulatory subunit 4 isoform X1 K15426 PPP4R4; serine/threonine-protein phosphatase 4 regulatory subunit 4
D AP-5 complex
E 100057559 AP5B1; AP-5 complex subunit beta-1 K19022 AP5B1; AP-5 complex subunit beta-1
E 100050758 AP5M1; AP-5 complex subunit mu-1 isoform X2 K19023 AP5M1; AP-5 complex subunit mu-1
E 100052366 AP5S1; AP-5 complex subunit sigma-1 isoform X1 K19024 AP5S1; AP-5 complex subunit sigma-1
E 100060677 AP5Z1; AP-5 complex subunit zeta-1 K19025 AP5Z1; AP-5 complex subunit zeta-1
D SMC5-SMC6 complex
E 100056086 SMC5; structural maintenance of chromosomes protein 5 isoform X1 K22803 SMC5; structural maintenance of chromosomes protein 5
E 100072064 SMC6; structural maintenance of chromosomes protein 6 isoform X1 K22804 SMC6; structural maintenance of chromosomes protein 6
E 106780840 FAM84A; protein FAM84A K22805 FAM84A; protein FAM84A
E 100066837 NSMCE1; non-structural maintenance of chromosomes element 1 homolog K22817 NSMCE1; non-structural maintenance of chromosomes element 1 [EC:2.3.2.27]
E 100067659 NSMCE2; E3 SUMO-protein ligase NSE2 isoform X3 K22756 NSMCE2; E3 SUMO-protein ligase NSE2 [EC:2.3.2.-]
E 106782075 NSMCE3; non-structural maintenance of chromosomes element 3 homolog K22823 NSMCE3; non-structural maintenance of chromosomes element 3
E 100064829 NSMCE4A; non-structural maintenance of chromosomes element 4 homolog A K22825 NSMCE4; non-structural maintenance of chromosomes element 4
E 102147697 EID3; EP300-interacting inhibitor of differentiation 3 K22826 EID3; EP300-interacting inhibitor of differentiation 3
E 100073233 SLF1; SMC5-SMC6 complex localization factor protein 1 K26126 SLF1; SMC5-SMC6 complex localization factor protein 1
E 100070315 SLF2; SMC5-SMC6 complex localization factor protein 2 isoform X1 K26127 SLF2; SMC5-SMC6 complex localization factor protein 2
D Other HR factors
E 100056366 EME1; crossover junction endonuclease EME1 isoform X1 K10882 EME1; crossover junction endonuclease EME1 [EC:3.1.22.-]
E 100146452 EME2; probable crossover junction endonuclease EME2 K10883 EME2; crossover junction endonuclease EME2
E 100053111 EXD2; exonuclease 3'-5' domain-containing protein 2 isoform X1 K20777 EXD2; exonuclease 3'-5' domain-containing protein 2 [EC:3.1.11.1]
E 100051745 MUS81; crossover junction endonuclease MUS81 K08991 MUS81; crossover junction endonuclease MUS81 [EC:3.1.22.-]
E 102150324 SEM1; LOW QUALITY PROTEIN: 26S proteasome complex subunit SEM1 K10881 SHFM1; 26 proteasome complex subunit DSS1
E 100059527 SFR1; swi5-dependent recombination DNA repair protein 1 homolog isoform X1 K10992 SFR1; Swi5-dependent recombination DNA repair protein 1
E 100066262 SLX1A; structure-specific endonuclease subunit SLX1 isoform X1 K15078 SLX1; structure-specific endonuclease subunit SLX1 [EC:3.6.1.-]
E 100069533 SLX4; structure-specific endonuclease subunit SLX4 isoform X1 K10484 BTBD12; structure-specific endonuclease subunit SLX4 (BTB/POZ domain-containing protein 12)
E 100072048 GEN1; flap endonuclease GEN homolog 1 K15338 GEN1; holliday junction resolvase GEN1/YEN1 [EC:3.1.-.-]
E 100070629 SPG11; spatacsin isoform X1 K19026 SPG11; spatacsin
E 100063436 ZFYVE26; zinc finger FYVE domain-containing protein 26 isoform X1 K19027 ZFYVE26; zinc finger FYVE domain-containing protein 26
E 100051365 RAD51AP1; RAD51-associated protein 1 isoform X1 K20778 RAD51AP1; RAD51-associated protein 1
E 100059897 MORF4L1; mortality factor 4-like protein 1 isoform X1 K11339 MORF4L1; mortality factor 4-like protein 1
E 111767506 mortality factor 4-like protein 1 isoform X1 K11339 MORF4L1; mortality factor 4-like protein 1
E 111775634 MORF4L1; mortality factor 4-like protein 1 isoform X1 K11339 MORF4L1; mortality factor 4-like protein 1
E 100069764 SAMHD1; deoxynucleoside triphosphate triphosphohydrolase SAMHD1 K22544 SAMHD1; deoxynucleoside triphosphate triphosphohydrolase SAMHD1 [EC:3.1.5.-]
E 100052497 FIGNL1; fidgetin-like protein 1 K22766 FIGNL1; fidgetin-like protein 1 [EC:5.6.2.-]
E 100050625 SPIDR; DNA repair-scaffolding protein isoform X1 K22806 SPIDR; DNA repair-scaffolding protein
E 106781014 FAM84B; protein FAM84B K22810 FAM84B; protein FAM84B
E 100058937 BRAT1; BRCA1-associated ATM activator 1 isoform X1 K23112 BRAT1; BRCA1-associated ATM activator 1
E 100050601 C26H21orf2; protein C21orf2 isoform X4 K23456 CFAP410; cilla- and flagella-associated protein
E 111774182 HDGFL2; LOW QUALITY PROTEIN: hepatoma-derived growth factor-related protein 2 K25065 HDGFL2; hepatoma-derived growth factor-related protein 2
E 100630877 ZSWIM7; zinc finger SWIM domain-containing protein 7 K25770 ZSWIM7; zinc finger SWIM domain-containing protein 7
E 100147390 SWSAP1; ATPase SWSAP1 K25771 SWSAP1; ATPase SWSAP1
E 100051651 EMSY; BRCA2-interacting transcriptional repressor EMSY isoform X7 K25790 EMSY; BRCA2-interacting transcriptional repressor EMSY
E 100051062 HSF2BP; heat shock factor 2-binding protein isoform X1 K25791 HSF2BP; heat shock factor 2-binding protein
E 100066022 MMS22L; protein MMS22-like isoform X1 K26125 MMS22L; protein MMS22-like
E 100064875 TONSL; tonsoku-like protein isoform X1 K09257 NFKBIL2; NF-kappa-B inhibitor-like protein 2
E 100056054 BOD1L1; biorientation of chromosomes in cell division protein 1-like 1 isoform X1 K27262 BOD1L1; biorientation of chromosomes in cell division protein 1-like 1
E 100053215 PARPBP; PCNA-interacting partner K27412 PARPBP; PCNA-interacting partner
C NHEJ (non-homologous end-joining)
D DNA-PK complex
E 100070684 XRCC6; X-ray repair cross-complementing protein 6 isoform X1 K10884 XRCC6; ATP-dependent DNA helicase 2 subunit 1
E 100055031 XRCC5; X-ray repair cross-complementing protein 5 isoform X1 K10885 XRCC5; ATP-dependent DNA helicase 2 subunit 2
E 791233 PRKDC; DNA-dependent protein kinase catalytic subunit K06642 PRKDC; DNA-dependent protein kinase catalytic subunit [EC:2.7.11.1]
D MRX complex
E 100060936 MRE11; double-strand break repair protein MRE11 isoform X2 K10865 MRE11; double-strand break repair protein MRE11
E 100063198 RAD50; DNA repair protein RAD50 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
D DNA Ligase 4 complex
E 100051479 LIG4; DNA ligase 4 K10777 LIG4; DNA ligase 4 [EC:6.5.1.1]
E 100065302 XRCC4; DNA repair protein XRCC4 K10886 XRCC4; DNA-repair protein XRCC4
E 100056056 NHEJ1; non-homologous end-joining factor 1 isoform X1 K10980 NHEJ1; non-homologous end-joining factor 1
D X-family DNA polymerases
E 100070125 POLL; DNA polymerase lambda isoform X1 K03512 POLL; DNA polymerase lambda [EC:2.7.7.7 4.2.99.-]
E 100051774 POLM; DNA-directed DNA/RNA polymerase mu isoform X2 K03513 POLM; DNA polymerase mu [EC:2.7.7.7]
E 100061113 DNTT; DNA nucleotidylexotransferase isoform X2 K00977 DNTT; DNA nucleotidylexotransferase [EC:2.7.7.31]
E 100050102 POLB; DNA polymerase beta K02330 POLB; DNA polymerase beta [EC:2.7.7.7 4.2.99.-]
D Other NHEJ factors
E 100068091 APTX; aprataxin isoform X1 K10863 APTX; aprataxin [EC:3.6.1.70 3.6.1.71 3.6.1.72]
E 100061683 APLF; aprataxin and PNK-like factor K13295 APLF; aprataxin and PNK-like factor [EC:3.1.-.-]
E 100056337 DCLRE1C; protein artemis isoform X1 K10887 DCLRE1C; DNA cross-link repair 1C protein [EC:3.1.-.-]
E 100067631 TDP2; tyrosyl-DNA phosphodiesterase 2 K19619 TDP2; tyrosyl-DNA phosphodiesterase 2 [EC:3.1.4.-]
E 100062029 SMCHD1; structural maintenance of chromosomes flexible hinge domain-containing protein 1 K23113 SMCHD1; structural maintenance of chromosomes flexible hinge domain-containing protein 1
E 100054863 MUM1L1; PWWP domain-containing protein MUM1L1 K23386 PWWP3; PWWP domain-containing DNA repair factor 3
E 100064632 PWWP domain-containing protein MUM1L1 K23386 PWWP3; PWWP domain-containing DNA repair factor 3
E 100068881 PWWP domain-containing protein MUM1 isoform X3 K23386 PWWP3; PWWP domain-containing DNA repair factor 3
E 111771568 LOW QUALITY PROTEIN: PWWP domain-containing protein MUM1L1-like K23386 PWWP3; PWWP domain-containing DNA repair factor 3
E 100146303 PAXX; protein PAXX isoform X1 K25772 PAXX; protein PAXX
E 100065055 C4H7orf49; cell cycle regulator of non-homologous end joining isoform X2 K26155 CYREN; cell cycle regulator of non-homologous end joining
E 100147047 JMJD8; jmjC domain-containing protein 8 isoform X1 K25792 JMJD8; jumonji domain-containing protein 8
E 100065580 C22H20orf196; uncharacterized protein C20orf196 homolog isoform X1 K26128 SHLD1; shieldin complex subunit 1
E 100064114 FAM35A; protein FAM35A K26129 SHLD2; shieldin complex subunit 2
C FA (Fanconi anemia) pathway
D FA core complex
E 100052495 FANCA; Fanconi anemia group A protein isoform X1 K10888 FANCA; fanconi anemia group A protein
E 100055607 FANCB; Fanconi anemia group B protein isoform X1 K10889 FANCB; fanconi anemia group B protein
E 100061359 FANCC; Fanconi anemia group C protein K10890 FANCC; fanconi anemia group C protein
E 100063042 FANCE; Fanconi anemia group E protein K10892 FANCE; fanconi anemia group E protein
E 100146695 FANCF; Fanconi anemia group F protein K10893 FANCF; fanconi anemia group F protein
E 100068211 FANCG; Fanconi anemia group G protein isoform X1 K10894 FANCG; fanconi anemia group G protein
E 100065770 FANCL; E3 ubiquitin-protein ligase FANCL isoform X1 K10606 FANCL; E3 ubiquitin-protein ligase FANCL [EC:2.3.2.27]
E 100063761 FANCM; Fanconi anemia group M protein isoform X1 K10896 FANCM; fanconi anemia group M protein
E 100056158 FAAP24; Fanconi anemia core complex-associated protein 24 isoform X1 K10898 FAAP24; fanconi anemia-associated protein
E 100055917 FAAP100; Fanconi anemia core complex-associated protein 100 K10993 FAAP100; fanconi anemia core complex 100 kDa subunit
D FA core complex binding factors
E 100069015 HES1; transcription factor HES-1 K06054 HES1; hairy and enhancer of split 1
E 100054784 CENPX; centromere protein X K15360 STRA13; centromere protein X
E 100063899 UBE2T; ubiquitin-conjugating enzyme E2 T K13960 UBE2T; ubiquitin-conjugating enzyme E2 T [EC:2.3.2.23]
D Bloom's syndrome complex (BTR)
E 100051666 TOP3A; DNA topoisomerase 3-alpha isoform X1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 100051153 TOP3B; DNA topoisomerase 3-beta-1 isoform X1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 100052791 RMI1; recQ-mediated genome instability protein 1 K10990 RMI1; RecQ-mediated genome instability protein 1
E 111767564 RMI2; recQ-mediated genome instability protein 2 K15365 RMI2; RecQ-mediated genome instability protein 2
D FANCD2-I complex
E 100051871 FANCD2; Fanconi anemia group D2 protein isoform X2 K10891 FANCD2; fanconi anemia group D2 protein
E 100069712 FANCI; Fanconi anemia group I protein isoform X1 K10895 FANCI; fanconi anemia group I protein
D Downstream FA components
E 100051990 BRCA1; breast cancer type 1 susceptibility protein isoform X4 K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 100064578 BRCA2; breast cancer type 2 susceptibility protein isoform X1 K08775 BRCA2; breast cancer 2 susceptibility protein
E 100071185 BRIP1; Fanconi anemia group J protein K15362 BRIP1; fanconi anemia group J protein [EC:5.6.2.3]
E 100069097 PALB2; partner and localizer of BRCA2 isoform X1 K10897 PALB2; partner and localizer of BRCA2
D Other FA pathway factors
E 100059669 FAN1; fanconi-associated nuclease 1 isoform X2 K15363 FAN1; fanconi-associated nuclease 1 [EC:3.1.21.- 3.1.4.1]
E 100071340 RAD51; DNA repair protein RAD51 homolog 1 K04482 RAD51; DNA repair protein RAD51
E 100070966 RAD51C; DNA repair protein RAD51 homolog 3 K10870 RAD51L2; RAD51-like protein 2
E 100067764 TELO2; telomere length regulation protein TEL2 homolog isoform X1 K11137 TELO2; telomere length regulation protein
E 100070397 USP1; ubiquitin carboxyl-terminal hydrolase 1 isoform X1 K11832 USP1; ubiquitin carboxyl-terminal hydrolase 1 [EC:3.4.19.12]
E 100068457 WDR48; WD repeat-containing protein 48 K15361 WDR48; WD repeat-containing protein 48
C Other DSBR factors
D Protein phosphatase 6
E 100070914 PPP6C; serine/threonine-protein phosphatase 6 catalytic subunit K15498 PPP6C; serine/threonine-protein phosphatase 6 catalytic subunit [EC:3.1.3.16]
E 100055529 PPP6R1; serine/threonine-protein phosphatase 6 regulatory subunit 1 isoform X3 K15499 PPP6R1; serine/threonine-protein phosphatase 6 regulatory subunit 1
E 100055355 PPP6R2; serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X1 K15500 PPP6R2; serine/threonine-protein phosphatase 6 regulatory subunit 2
E 100053490 PPP6R3; serine/threonine-protein phosphatase 6 regulatory subunit 3 K15501 PPP6R3; serine/threonine-protein phosphatase 6 regulatory subunit 3
E 100052418 ANKRD28; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A isoform X1 K15502 ANKRD28; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A
E 100070473 ANKRD44; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B isoform X1 K15503 ANKRD44; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B
E 100059440 ANKRD52; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C K15504 ANKRD52; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C
D Ubiquitin ligases
E 100053995 RNF8; E3 ubiquitin-protein ligase RNF8 isoform X1 K10667 RNF8; E3 ubiquitin-protein ligase RNF8 [EC:2.3.2.27]
E 100069836 RNF168; E3 ubiquitin-protein ligase RNF168 K20779 RNF168; E3 ubiquitin-protein ligase RNF168 [EC:2.3.2.31]
E 100064984 RNF169; E3 ubiquitin-protein ligase RNF169 K20805 RNF169; E3 ubiquitin-protein ligase RNF169 [EC:2.3.2.31]
E 100050955 HERC2; E3 ubiquitin-protein ligase HERC2 isoform X1 K10595 HERC2; E3 ubiquitin-protein ligase HERC2 [EC:2.3.2.26]
D Others
E 100146731 WRAP53; telomerase Cajal body protein 1 K23314 WRAP53; telomerase Cajal body protein 1
E 100146716 TPRN; taperin K24164 TPRN; taperin
E 100068927 ZCWPW1; zinc finger CW-type PWWP domain protein 1 isoform X1 K24688 ZCWPW1; zinc finger CW-type PWWP domain protein 1
E 100053352 WDR70; WD repeat-containing protein 70 K24752 WDR70; WD repeat-containing protein 70
E 100070718 WDR76; WD repeat-containing protein 76 isoform X1 K24755 WDR76; WD repeat-containing protein 76
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
D 100067518 POLH; DNA polymerase eta K03509 POLH; DNA polymerase eta [EC:2.7.7.7]
D 100070107 POLI; DNA polymerase iota isoform X1 K03510 POLI; DNA polymerase iota [EC:2.7.7.7]
D 100065534 POLK; DNA polymerase kappa K03511 POLK; DNA polymerase kappa [EC:2.7.7.7]
D 100050347 REV1; DNA repair protein REV1 isoform X2 K03515 REV1; DNA repair protein REV1 [EC:2.7.7.-]
C B-family DNA polymerases
D 100072399 REV3L; DNA polymerase zeta catalytic subunit isoform X1 K02350 REV3L; DNA polymerase zeta [EC:2.7.7.7]
C A-family DNA polymerase
D 100051163 POLN; DNA polymerase nu isoform X2 K16618 POLN; DNA polymerase nu [EC:2.7.7.7]
C Rad6 epistasis group
D 100058679 UBE2A; ubiquitin-conjugating enzyme E2 A K10573 UBE2A; ubiquitin-conjugating enzyme E2 A [EC:2.3.2.23]
D 100062920 UBE2B; ubiquitin-conjugating enzyme E2 B K10574 UBE2B; ubiquitin-conjugating enzyme E2 B [EC:2.3.2.23]
D 100052645 RAD18; E3 ubiquitin-protein ligase RAD18 isoform X2 K10627 RAD18; E3 ubiquitin-protein ligase RAD18 [EC:2.3.2.27]
D 100058775 HLTF; helicase-like transcription factor isoform X1 K15711 SMARCA3; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A3 [EC:5.6.2. 2.3.2.27]
D 100051373 UBE2V2; ubiquitin-conjugating enzyme E2 variant 2 K10704 UBE2V; ubiquitin-conjugating enzyme E2 variant
D 102150563 UBE2V1; ubiquitin-conjugating enzyme E2 variant 1 isoform X3 K10704 UBE2V; ubiquitin-conjugating enzyme E2 variant
D 100051493 UBE2N; ubiquitin-conjugating enzyme E2 N K10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23]
D 102150222 ubiquitin-conjugating enzyme E2 N K10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23]
C Other TLS factors
D 100052065 PCNA; proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
D 100053215 PARPBP; PCNA-interacting partner K27412 PARPBP; PCNA-interacting partner
D 100060623 SPRTN; sprT-like domain-containing protein Spartan K24051 SPRTN; SprT-like domain-contaning protein Spartan
D 102147656 GCNA; acidic repeat-containing protein isoform X2 K26957 GCNA; germ cell nuclear acidic protein
B Check point factors
C Rad9-Hus1-Rad1 complex
D 100059194 RAD9A; cell cycle checkpoint control protein RAD9A isoform X1 K10994 RAD9A; cell cycle checkpoint control protein RAD9A [EC:3.1.11.2]
D 100147205 RAD9B; cell cycle checkpoint control protein RAD9B isoform X1 K10995 RAD9B; cell cycle checkpoint control protein RAD9B
D 100066083 HUS1; checkpoint protein HUS1 isoform X3 K10903 HUS1; HUS1 checkpoint protein
D 100053946 RAD1; cell cycle checkpoint protein RAD1 isoform X1 K02830 HRAD1; cell cycle checkpoint protein [EC:3.1.11.2]
C HRAD17(Rad24)-RFC complex
D 100065769 RAD17; cell cycle checkpoint protein RAD17 isoform X1 K06662 HRAD17; cell cycle checkpoint protein
D 100068189 RFC4; replication factor C subunit 4 K10755 RFC2_4; replication factor C subunit 2/4
D 100059980 RFC2; replication factor C subunit 2 isoform X2 K10755 RFC2_4; replication factor C subunit 2/4
D 100062326 RFC3; replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
D 100054946 RFC5; replication factor C subunit 5 K10756 RFC3_5; replication factor C subunit 3/5
C Rad17-Mec3-Ddc1 complex
D 100053946 RAD1; cell cycle checkpoint protein RAD1 isoform X1 K02830 HRAD1; cell cycle checkpoint protein [EC:3.1.11.2]
C FPC (fork protection complex)
D 100059661 TIMELESS; protein timeless homolog K10997 TIMELESS; replication fork protection complex subunit TIMELESS/Tof1/Swi1
D 100066048 TIPIN; TIMELESS-interacting protein K10998 TIPIN; replication fork protection complex subunit TIPIN/Csm3/Swi3
D 100055244 CLSPN; claspin K25773 CLSPN; claspin
C Triple T complex
D 100067764 TELO2; telomere length regulation protein TEL2 homolog isoform X1 K11137 TELO2; telomere length regulation protein
D 100055499 TTI1; TELO2-interacting protein 1 homolog K20403 TTI1; TELO2-interacting protein 1
D 100061066 TTI2; TELO2-interacting protein 2 K23115 TTI2; TELO2-interacting protein 2
C BAG6-UBL4A-GET4 complex
D 100050296 BAG6; large proline-rich protein BAG6 isoform X5 K23390 BAG6; large proline-rich protein BAG6
D 100059665 UBL4A; ubiquitin-like protein 4A K23388 UBL4; ubiquitin-like protein 4
D 100062023 UBL4B; ubiquitin-like protein 4B K23388 UBL4; ubiquitin-like protein 4
D 100054023 GET4; Golgi to ER traffic protein 4 homolog isoform X1 K23387 GET4; golgi to ER traffic protein 4
C Other check point factors
D 100062529 ATR; serine/threonine-protein kinase ATR isoform X1 K06640 ATR; serine/threonine-protein kinase ATR [EC:2.7.11.1]
D 100063799 ATRIP; ATR-interacting protein isoform X1 K10905 ATRIP; ATR interacting protein
D 100061765 ATM; serine-protein kinase ATM K04728 ATM; serine-protein kinase ATM [EC:2.7.11.1]
D 100062044 TP53; cellular tumor antigen p53 K04451 TP53; tumor protein p53
D 100064353 CHEK1; serine/threonine-protein kinase Chk1 K02216 CHEK1; serine/threonine-protein kinase CHEK1 [EC:2.7.11.1]
D 100059288 CHEK2; serine/threonine-protein kinase Chk2 isoform X1 K06641 CHEK2; serine/threonine-protein kinase CHEK2 [EC:2.7.11.1]
D 100064223 CDC25A; M-phase inducer phosphatase 1 K06645 CDC25A; M-phase inducer phosphatase 1 [EC:3.1.3.48]
D 100052425 CDC25B; M-phase inducer phosphatase 2 K05866 CDC25B; M-phase inducer phosphatase 2 [EC:3.1.3.48]
D 100062352 CDC25C; M-phase inducer phosphatase 3 isoform X3 K05867 CDC25C; M-phase inducer phosphatase 3 [EC:3.1.3.48]
D 100056060 YWHAZ; 14-3-3 protein zeta/delta K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
D 100056084 YWHAB; 14-3-3 protein beta/alpha K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
D 100057123 YWHAQ; 14-3-3 protein theta K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
D 100062878 YWHAH; 14-3-3 protein eta K16198 YWHAG_H; 14-3-3 protein gamma/eta
D 100059731 YWHAG; 14-3-3 protein gamma K16198 YWHAG_H; 14-3-3 protein gamma/eta
D 100059962 YWHAE; 14-3-3 protein epsilon isoform X1 K06630 YWHAE; 14-3-3 protein epsilon
D 100071978 NAV2; neuron navigator 2 isoform X4 K19483 NAV2; neuron navigator 2 [EC:5.6.2.4]
D 100071182 WEE1; wee1-like protein kinase K06632 WEE1; wee1-like protein kinase [EC:2.7.11.1]
D 100065530 WEE2; wee1-like protein kinase 2 K06632 WEE1; wee1-like protein kinase [EC:2.7.11.1]
D 100073046 PER1; period circadian protein homolog 1 isoform X1 K21944 PER1; period circadian protein 1
D 100034167 PER2; period circadian protein homolog 2 K02633 PER2; period circadian protein 2
D 100630305 PER3; period circadian protein homolog 3 isoform X1 K21945 PER3; period circadian protein 3
D 100055473 MDC1; mediator of DNA damage checkpoint protein 1 isoform X1 K20780 MDC1; mediator of DNA damage checkpoint protein 1
D 100053927 PLS3; plastin-3 K17336 PLS3; plastin-3
D 100069794 AEN; apoptosis-enhancing nuclease isoform X2 K18340 AEN; apoptosis-enhancing nuclease [EC:3.1.-.-]
D 100065793 PLK3; serine/threonine-protein kinase PLK3 K08862 PLK3; polo-like kinase 3 [EC:2.7.11.21]
D 100146835 PLK5; inactive serine/threonine-protein kinase PLK5 isoform X1 K19596 PLK5; inactive serine/threonine-protein kinase PLK5
D 100061302 NEK1; serine/threonine-protein kinase Nek1 isoform X1 K08857 NEK1_4_5; serine/threonine-protein kinase Nek1/4/5 [EC:2.7.11.1]
D 100052593 NEK5; serine/threonine-protein kinase Nek5 isoform X3 K08857 NEK1_4_5; serine/threonine-protein kinase Nek1/4/5 [EC:2.7.11.1]
D 100051545 NEK4; serine/threonine-protein kinase Nek4 isoform X1 K08857 NEK1_4_5; serine/threonine-protein kinase Nek1/4/5 [EC:2.7.11.1]
D 100051334 NEK10; serine/threonine-protein kinase Nek10 isoform X1 K20879 NEK10; serine/threonine-protein kinase Nek10 [EC:2.7.11.1]
D 100064611 NEK11; serine/threonine-protein kinase Nek11 isoform X1 K20880 NEK11; serine/threonine-protein kinase Nek11 [EC:2.7.11.1]
D 100063043 DONSON; protein downstream neighbor of Son K22422 DONSON; protein downstream neighbor of Son
D 100050757 KANK1; KN motif and ankyrin repeat domain-containing protein 1 isoform X1 K22808 KANK; KN motif and ankyrin repeat domain-containing protein
D 100070416 KANK4; KN motif and ankyrin repeat domain-containing protein 4 K22808 KANK; KN motif and ankyrin repeat domain-containing protein
D 100629179 KANK2; KN motif and ankyrin repeat domain-containing protein 2 K22808 KANK; KN motif and ankyrin repeat domain-containing protein
D 102148138 KANK3; KN motif and ankyrin repeat domain-containing protein 3 K22808 KANK; KN motif and ankyrin repeat domain-containing protein
D 102148981 KLLN; LOW QUALITY PROTEIN: killin K23389 KLLN; killin
D 100071612 schlafen family member 11 K24458 SLFN11; schlafen family member 11 [EC:3.6.-.-]
D 100057184 CHMP4C; charged multivesicular body protein 4c isoform X1 K24782 CHMP4C; charged multivesicular body protein 4C
D 100051010 VPS4B; vacuolar protein sorting-associated protein 4B K12196 VPS4; vacuolar protein-sorting-associated protein 4
D 100067034 VPS4A; vacuolar protein sorting-associated protein 4A isoform X1 K12196 VPS4; vacuolar protein-sorting-associated protein 4
D 100071308 ZFYVE19; abscission/NoCut checkpoint regulator K24778 ZFYVE19; abscission/NoCut checkpoint regulator
D 100054411 SDE2; replication stress response regulator SDE2 K25059 SDE2; replication stress response regulator SDE2
B Other factors with a suspected DNA repair function
C DNA polymerases
D 100060882 POLQ; DNA polymerase theta isoform X1 K02349 POLQ; DNA polymerase theta [EC:2.7.7.7]
D 100072728 MYBBP1A; myb-binding protein 1A K02331 POL5; DNA polymerase phi [EC:2.7.7.7]
D 100058061 PRIMPOL; DNA-directed primase/polymerase protein isoform X1 K22761 PRIMPOL; DNA-directed primase/polymerase protein [EC:2.7.7.102 2.7.7.7]
C Nucleases
D 100063767 TREX1; three-prime repair exonuclease 1 K10790 TREX1; three prime repair exonuclease 1 [EC:3.1.11.2]
D 100057632 TREX2; three prime repair exonuclease 2 K10791 TREX2; three prime repair exonuclease 2 [EC:3.1.11.2]
D 100068217 DCLRE1A; DNA cross-link repair 1A protein isoform X1 K15340 DCLRE1A; DNA cross-link repair 1A protein
D 100065015 DCLRE1B; 5' exonuclease Apollo isoform X1 K15341 DCLRE1B; DNA cross-link repair 1B protein [EC:3.1.-.-]
D 100053943 EXO5; exonuclease V K17815 EXO5; exonuclease V [EC:3.1.-.-]
D 100056365 ENDOV; endonuclease V isoform X1 K21813 ENDOV; endonuclease V [EC:3.1.26.-]
D 100050746 ZRANB3; DNA annealing helicase and endonuclease ZRANB3 isoform X1 K25861 ZRANB3; DNA annealing helicase and endonuclease ZRANB3 [EC:5.6.2.- 3.1.-.-]
C Helicases
D 100052320 HELQ; helicase POLQ-like isoform X1 K19178 HELQ; POLQ-like helicase [EC:5.6.2.4]
D 100063182 ERCC6L2; DNA excision repair protein ERCC-6-like 2 isoform X1 K20098 ERCC6L2; DNA excision repair protein ERCC-6-like 2 [EC:5.6.2.-]
C PSO4 complex
D 100059076 PRPF19; pre-mRNA-processing factor 19 K10599 PRPF19; pre-mRNA-processing factor 19 [EC:2.3.2.27]
D 100055574 CDC5L; cell division cycle 5-like protein K12860 CDC5L; pre-mRNA-splicing factor CDC5/CEF1
D 100065284 BCAS2; pre-mRNA-splicing factor SPF27 K12861 BCAS2; pre-mRNA-splicing factor SPF27
D 100062153 PLRG1; pleiotropic regulator 1 K12862 PLRG1; pleiotropic regulator 1
C Modulation of nucleotide pools
D 100057367 NUDT15; nucleotide triphosphate diphosphatase NUDT15 K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D 100059629 NUDT1; 7,8-dihydro-8-oxoguanine triphosphatase K17816 NUDT1; 8-oxo-dGTP diphosphatase / 2-hydroxy-dATP diphosphatase [EC:3.6.1.55 3.6.1.56]
D 100056631 NUDT18; 8-oxo-dGDP phosphatase NUDT18 K17817 NUDT18; 8-oxo-dGDP phosphatase [EC:3.6.1.58]
D 100070214 DUT; deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial isoform X1 K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 106782180 deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial isoform X1 K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 100053126 RRM1; ribonucleoside-diphosphate reductase large subunit isoform X1 K10807 RRM1; ribonucleoside-diphosphate reductase subunit M1 [EC:1.17.4.1]
D 100072410 RRM2; ribonucleoside-diphosphate reductase subunit M2 isoform X1 K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]
D 100062030 RRM2B; ribonucleoside-diphosphate reductase subunit M2 B isoform X1 K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]
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AProkaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D 100049801 MGMT; methylated-DNA--protein-cysteine methyltransferase isoform X5 K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
C BER (base exicision repair)
D DNA glycosylases
E 100059759 UNG; uracil-DNA glycosylase K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E 100064502 SMUG1; single-strand selective monofunctional uracil DNA glycosylase K10800 SMUG1; single-strand selective monofunctional uracil DNA glycosylase [EC:3.2.2.-]
E 100065027 MPG; DNA-3-methyladenine glycosylase K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]
E 100065659 NTHL1; endonuclease III-like protein 1 isoform X1 K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
D RecJ
D DNA ligase
D DNA polymerase I
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase complex (RNAP)
E TRCF (transcription-repair coupling factor)
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
D Molecular matchmaker
D Strand discrimination factor
D DNA exonucleases
D DNA polymerase III holoenzyme
D DNA ligase
D Other MMR factors
E 100629380 SSBP1; single-stranded DNA-binding protein, mitochondrial isoform X5 K03111 ssb; single-strand DNA-binding protein
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D RecBC pathway proteins
D RecFOR pathway proteins
D AddAB pathway proteins
D Other HR factor
D Archaeal homologous recombinant proteins
C NHEJ (non-homologous end-joining)
D Two-component NHEJ DNA repair complex
D SHIIR (short-homology-independent illegitimate recombination)
E Facilitator
E Supressor
D SHDIR (short-homology-dependent illegitimate recombination)
E RecET pathway
E Facilitator
E Supressor
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
C Other SOS response factors
D 100629380 SSBP1; single-stranded DNA-binding protein, mitochondrial isoform X5 K03111 ssb; single-strand DNA-binding protein
B Other factors with a suspected DNA repair function
C DNA polymerase
C DNA helicases
C Modulation of nucleotide pools
D 100057367 NUDT15; nucleotide triphosphate diphosphatase NUDT15 K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D 100070214 DUT; deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial isoform X1 K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 106782180 deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial isoform X1 K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
C Others
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: March 29, 2024