+C Two-component system KO
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Two-Component System - Escherichia coli K-12 W3110
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AOmpR family
B PhoR-PhoB (phosphate starvation response)
C JW0390 phoR; sensory histidine kinase in two-component regulatory system with PhoB K07636 phoR; two-component system, OmpR family, phosphate regulon sensor histidine kinase PhoR [EC:2.7.13.3]
C JW0389 phoB; DNA-binding response regulator in two-component regulatory system with PhoR (or CreC) K07657 phoB; two-component system, OmpR family, phosphate regulon response regulator PhoB
B SenX3-RegX3 (phosphate starvation response)
B PhoQ-PhoP (magnesium transport)
C JW1115 phoQ; sensory histidine kinase in two-compoent regulatory system with PhoP K07637 phoQ; two-component system, OmpR family, sensor histidine kinase PhoQ [EC:2.7.13.3]
C JW1116 phoP; DNA-binding response regulator in two-component regulatory system with PhoQ K07660 phoP; two-component system, OmpR family, response regulator PhoP
B EnvZ-OmpR (osmotic stress response)
C JW3367 envZ; sensory histidine kinase in two-component regulatory system with OmpR K07638 envZ; two-component system, OmpR family, osmolarity sensor histidine kinase EnvZ [EC:2.7.13.3]
C JW3368 ompR; DNA-binding response regulator in two-component regulatory system with EnvZ K07659 ompR; two-component system, OmpR family, phosphate regulon response regulator OmpR
B RstB-RstA
C JW1601 rstB; sensory histidine kinase in two-component regulatory system with RstA K07639 rstB; two-component system, OmpR family, sensor histidine kinase RstB [EC:2.7.13.3]
C JW1600 rstA; DNA-bindng response regulator in two-component regulatory system with RstB K07661 rstA; two-component system, OmpR family, response regulator RstA
B CpxA-CpxR (envelope stress response)
C JW3882 cpxA; sensory histidine kinase in two-component regulatory system with CpxR K07640 cpxA; two-component system, OmpR family, sensor histidine kinase CpxA [EC:2.7.13.3]
C JW3883 cpxR; DNA-binding response regulator in two-component regulatory system with CpxA K07662 cpxR; two-component system, OmpR family, response regulator CpxR
B CssS-CssR (secretion stress response)
B CreC-CreB (phosphate regulation)
C JW4362 creC; sensory histidine kinase in two-component regulatory system with CreB or PhoB, regulator of the CreBC regulon K07641 creC; two-component system, OmpR family, sensor histidine kinase CreC [EC:2.7.13.3]
C JW4361 creB; DNA-binding response regulator in two-component regulatory system with CreC K07663 creB; two-component system, OmpR family, catabolic regulation response regulator CreB
B BaeS-BaeR (envelope stress response)
C JW2063 baeS; sensory histidine kinase in two-component regulatory system with BaeR K07642 baeS; two-component system, OmpR family, sensor histidine kinase BaeS [EC:2.7.13.3]
C JW2064 baeR; DNA-binding response regulator in two-component regulatory system with BaeS K07664 baeR; two-component system, OmpR family, response regulator BaeR
B BasS-BasR (antimicrobial peptide resistance)
C JW4073 basS; sensory histidine kinase in two-component regulatory system with BasR K07643 basS; two-component system, OmpR family, sensor histidine kinase BasS [EC:2.7.13.3]
C JW4074 basR; DNA-binding response regulator in two-component regulatory system with BasS K07771 basR; two-component system, OmpR family, response regulator BasR
B CusS-CusR (copper tolerance)
C JW5082 cusS; sensory histidine kinase in two-component regulatory system with CusR, senses copper ions K07644 cusS; two-component system, OmpR family, heavy metal sensor histidine kinase CusS [EC:2.7.13.3]
C JW0560 cusR; DNA-binding response regulator in two-component regulatory system with CusS K07665 cusR; two-component system, OmpR family, copper resistance phosphate regulon response regulator CusR
B QseC-QseB (quorum sensing)
C JW2994 qseC; sensory histidine kinase in two-component regulatory system with QseB K07645 qseC; two-component system, OmpR family, sensor histidine kinase QseC [EC:2.7.13.3]
C JW2993 qseB; DNA-binding response regulator in two-component regulatory system with QseC K07666 qseB; two-component system, OmpR family, response regulator QseB
B KdpD-KdpE (potassium transport)
C JW0683 kdpD; fused sensory histidine kinase in two-component regulatory system with KdpE K07646 kdpD; two-component system, OmpR family, sensor histidine kinase KdpD [EC:2.7.13.3]
C JW5096 kdpE; DNA-binding response regulator in two-component regulatory system with KdpD K07667 kdpE; two-component system, OmpR family, KDP operon response regulator KdpE
B TorS-TorR (TMAO respiration)
C JW5135 torS; hybrid sensory histidine kinase in two-component regulatory system with TorR K07647 torS; two-component system, OmpR family, sensor histidine kinase TorS [EC:2.7.13.3]
C JW0980 torR; DNA-binding response regulator in two-component regulatory system with TorS K07772 torR; two-component system, OmpR family, torCAD operon response regulator TorR
B ArcB-ArcA (anoxic redox control)
C JW5536 arcB; hybrid sensory histidine kinase in two-component regulatory system with ArcA K07648 arcB; two-component system, OmpR family, aerobic respiration control sensor histidine kinase ArcB [EC:2.7.13.3]
C JW4364 arcA; DNA-binding response regulator in two-component regulatory system with ArcB or CpxA K07773 arcA; two-component system, OmpR family, aerobic respiration control protein ArcA
B TctE-TctD (tricarboxylic acid transport)
B ResE-ResD (aerobic and anaerobic respiration)
B VicK-VicR (cell wall metabolism)
B MprB-MprA (maintenance of persistent infection)
B MtrB-MtrA (osmotic stress response)
B PrrB-PrrA (intracellular multiplication)
B TrcS-TrcR
B NrsS-NrsR (nickel tolerance)
B ManS-ManR (manganese homeostasis)
B NblS-NblR (photosynthesis)
B SasA-RpaAB (circadian timing mediating)
B SaeS-SaeR (staphylococcal virulence regulation)
B BceS-BceR (bacitracin transport)
B BraS-BraR (bacitracin transport)
B GraS-GraR (cationic antimicrobial peptide transport)
B YxdK-YxdJ (antimicrobial peptide response)
B ChvG-ChvI (acidity sensing)
B CiaH-CiaR
B ParS-ParR (polymyxin-adaptive resistance)
B AdeS-AdeR
B VanS-VanR (VanB type vancomycin resistance)
B VanS-VanR (VanE type vancomycin resistance)
B VanS-VanR (actinomycete type vancomycin resistance)
B ArlS-ArlR (virulence regulation)
B Ihk-Irr (virulence regulation)
B PfeS-PfeR (enterobactin-dependent iron acquisition)
B NisK-NisR (lantibiotic biosynthesis)
B Unclassified
C JW1951 yedV; predicted sensory kinase in two-component regulatory system with YedW K02484 K02484; two-component system, OmpR family, sensor kinase [EC:2.7.13.3]
C JW5322 yedW; predicted DNA-binding response regulator in two-component system withYedV K02483 K02483; two-component system, OmpR family, response regulator
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ANarL family
B NarX-NarL (nitrate respiration)
C JW1213 narX; sensory histidine kinase in two-component regulatory system with NarL K07673 narX; two-component system, NarL family, nitrate/nitrite sensor histidine kinase NarX [EC:2.7.13.3]
C JW1212 narL; DNA-binding response regulator in two-component regulatory system with NarX (or NarQ) K07684 narL; two-component system, NarL family, nitrate/nitrite response regulator NarL
B NarQ-NarP (nitrate respiration)
C JW2453 narQ; sensory histidine kinase in two-component regulatory system with NarP (NarL) K07674 narQ; two-component system, NarL family, nitrate/nitrite sensor histidine kinase NarQ [EC:2.7.13.3]
C JW2181 narP; DNA-binding response regulator in two-component regulatory system with NarQ or NarX K07685 narP; two-component system, NarL family, nitrate/nitrite response regulator NarP
B UhpB-UhpA (hexose phosphates uptake)
C JW3643 uhpB; sensory histidine kinase in two-component regulatory sytem with UhpA K07675 uhpB; two-component system, NarL family, sensor histidine kinase UhpB [EC:2.7.13.3]
C JW3644 uhpA; DNA-binding response regulator in two-component regulatory system wtih UhpB K07686 uhpA; two-component system, NarL family, uhpT operon response regulator UhpA
B FusK-FusR (virulence regulation)
B RcsC-RcsD-RcsB (capsule synthesis)
C JW5920 rcsC; hybrid sensory kinase in two-component regulatory system with RcsB and YojN K07677 rcsC; two-component system, NarL family, capsular synthesis sensor histidine kinase RcsC [EC:2.7.13.3]
C JW2204 rcsD; phosphotransfer intermediate protein in two-component regulatory system with RcsBC K07676 rcsD; two-component system, NarL family, sensor histidine kinase RcsD [EC:2.7.13.3]
C JW2205 rcsB; DNA-binding response regulator in two-component regulatory system with RcsC and YojN K07687 rcsB; two-component system, NarL family, captular synthesis response regulator RcsB
B BarA-UvrY (central carbon metabolism)
C JW2757 barA; hybrid sensory histidine kinase, in two-component regulatory system with UvrY K07678 barA; two-component system, NarL family, sensor histidine kinase BarA [EC:2.7.13.3]
C JW1899 uvrY; DNA-binding response regulator in two-component regulatory system with BarA K07689 uvrY; two-component system, NarL family, invasion response regulator UvrY
B ComP-ComA (competence)
B EvgS-EvgA (acid and drug tolerance)
C JW2367 evgS; hybrid sensory histidine kinase in two-component regulatory system with EvgA K07679 evgS; two-component system, NarL family, sensor histidine kinase EvgS [EC:2.7.13.3]
C JW2366 evgA; DNA-binding response regulator in two-component regulatory system with EvgS K07690 evgA; two-component system, NarL family, response regulator EvgA
C JW5073 fimZ; predicted DNA-binding transcriptional regulator K07688 fimZ; two-component system, NarL family, response regulator, fimbrial Z protein, FimZ
B DegS-DegU (multicellular behavior control)
B DesK-DesR (membrane lipid fluidity regulation)
B VraS-VraR (cell-wall peptidoglycan synthesis)
B LiaS-LiaR (cell wall stress response)
B DevS-DevR (redox response)
B NreB-NreC (dissimilatory nitrate/nitrite reduction)
B YdfH-YdfI
B SalK-SalR
B PprA–PprB (biofilm formation)
B Unclassified
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ASpo family
B KinABCDE-Spo0FA (sporulation control)
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ACitB family
B CitA-CitB (citrate fermentation)
C JW0611 citA; sensory histidine kinase in two-component regulatory system with citB K07700 dpiB; two-component system, CitB family, cit operon sensor histidine kinase CitA [EC:2.7.13.3]
C JW0612 citB; DNA-binding response regulator in two-component regulatory system with citA K07702 dpiA; two-component system, CitB family, response regulator CitB
B CitS-CitT (magnesium-citrate transport)
B DcuS-DcuR (C4-dicarboxylate metabolism)
C JW4086 dcuS; sensory histidine kinase in two-component regulatory system with DcuR, regulator of anaerobic fumarate respiration K07701 dcuS; two-component system, CitB family, sensor histidine kinase DcuS [EC:2.7.13.3]
C JW4085 dcuR; DNA-binding response regulator in two-component regulatory system with DcuS K07703 dcuR; two-component system, CitB family, response regulator DcuR
B DctS-DctR (C4-dicarboxylate transport)
B MalK-MalR (malate transport)
B Unclassified
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ALytTR family
B LysS-LysR
B AlgZ-AlgR (alginate production)
B NatK-NatR (sodium extrusion)
B AgrC-AgrA (exoprotein synthesis)
B AgrC2-AgrA2 (virulence regulation)
B ComD-ComE (competence)
B Unclassified
C JW5353 yehU; predicted sensory kinase in two-component system with YehT K02478 K02478; two-component system, LytTR family, sensor kinase [EC:2.7.13.3]
C JW5388 ypdA; predicted sensory kinase in two-component system with YpdB K02478 K02478; two-component system, LytTR family, sensor kinase [EC:2.7.13.3]
C JW2378 ypdB; predicted response regulator in two-component system withYpdA K02477 K02477; two-component system, LytTR family, response regulator
C JW5352 yehT; predicted response regulator in two-component system withYehU K02477 K02477; two-component system, LytTR family, response regulator
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ANtrC family
B GlnL-GlnG (nitrogen regulation)
C JW3840 glnL; sensory kinase in two-component regulatory system with GlnG K07708 glnL; two-component system, NtrC family, nitrogen regulation sensor histidine kinase GlnL [EC:2.7.13.3]
C JW3839 glnG; fused DNA-binding response regulator in two-component regulatory system with GlnL, nitrogen regulator I (NRI) K07712 glnG; two-component system, NtrC family, nitrogen regulation response regulator GlnG
B NtrY-NtrX (nitrogen regulation)
B HydH-HydG (metal tolerance)
C JW3967 zraS; sensory histidine kinase in two-component regulatory system with ZraR K07709 zraS; two-component system, NtrC family, sensor histidine kinase HydH [EC:2.7.13.3]
C JW3968 zraR; fused DNA-binding response regulator in two-component regulatory system with ZraS K07713 zraR; two-component system, NtrC family, response regulator HydG
B AtoS-AtoC (cPHB biosynthesis)
C JW2213 atoS; sensory histidine kinase in two-component regulatory system with AtoC K07710 atoS; two-component system, NtrC family, sensor histidine kinase AtoS [EC:2.7.13.3]
C JW2214 atoC; fused response regulator of ato opeon, in two-component system with AtoS K07714 atoC; two-component system, NtrC family, response regulator AtoC
B PilS-PilR (type 4 fimbriae synthesis)
B GlrK-GlrR (amino sugar metabolism)
C JW5407 yfhK; predicted sensory kinase in two-component system K07711 glrK; two-component system, NtrC family, sensor histidine kinase GlrK [EC:2.7.13.3]
C JW2538 yfhA; predicted DNA-binding response regulator in two-component system K07715 glrR; two-component system, NtrC family, response regulator GlrR
B PgtB-PgtA (phosphoglycerate transport)
B DctB-DctD (C4-dicarboxylate transport)
B KinB-AlgB (alginate production)
B HupT-HupR (hydrogenase synthesis regulation)
B Unclassified
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ACheA family
B CheA-CheYBV (chemotaxis)
C JW1877 cheA; fused chemotactic sensory histidine kinase (soluble) in two-component regulatory system with CheB and CheY K03407 cheA; two-component system, chemotaxis family, sensor kinase CheA [EC:2.7.13.3]
C JW1871 cheY; chemotaxis regulator transmitting signal to flagellar motor component K03413 cheY; two-component system, chemotaxis family, chemotaxis protein CheY
C JW1872 cheB; fused chemotaxis regulator and protein-glutamate methylesterase in two-component regulatory system with CheA K03412 cheB; two-component system, chemotaxis family, protein-glutamate methylesterase/glutaminase [EC:3.1.1.61 3.5.1.44]
B ChpA-ChpB/PilGH (chemosensory)
B PixL-PixGH (positive phototaxis)
B WspE-WspRF (chemosensory)
B Cph1-Rcp1 (light response)
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ACell cycle family
B PleC-PleD (cell fate control)
B CckA-CtrA/CpdR (cell cycle control)
B Hk1-Rrp1 (glycerol uptake and utilization)
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ALux family
B LuxQN/CqsS-LuxU-LuxO (quorum sensing)
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ALuxR family
B DctS-DctR (C4-dicarboxylate transport)
B TtrS-TtrR (tetrathionate respiration)
B FixL-FixJ (nitrogen fixation)
B SsrA-SsrB
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AOther families
B FlrB-FlrC (polar flagellar synthesis)
B AauS-AauR (acidic amino acids utilization)
B SLN1-YPD1-SSK1/SKN7 (osmosensing)
B RpfC-RpfG (cell-to-cell signaling)
B GlnK-GlnL (glutamine utilization)
B HspS-HspR (hexose phosphates uptake)
B YesM-YesN
B CikA
B RegB-RegA (redox response)
B FitF-FitH (insecticidal toxin regulation)
B PhcS-PhcRQ
B SagS-HptB-HsbR (swarming activity and biofilm formation)
B PdtaS-PdtaR
B NasS-NasT
B Unclassified
C JW1223 rssB; response regulator of RpoS K02485 rssB; two-component system, response regulator
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: December 14, 2023