+F Repair protein KO
#
DNA Repair and Recombination Proteins - Escherichia coli DH1
%
!
AEukaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D EcDH1_2309 methylated-DNA/protein-cysteine methyltransferase K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
D EcDH1_2928 Deoxyribodipyrimidine photo-lyase K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]
C BER (base exicision repair)
D DNA glycosylases
E EcDH1_1088 uracil-DNA glycosylase K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E EcDH1_0734 A/G-specific adenine glycosylase K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
E EcDH1_2008 endonuclease III K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
D Long Patch-BER factors
E DNA polymerase delta complex
E DNA polymerase epsilon complex
D Short Patch-BER factors
D Other BER factors
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E XPC-HR23B-CETN2 complex
E Cul4-DDB2 complex
E NER4 complex
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase II complex
E Cul4-CSA complex
E Other TCR factor
D TFIIH complex
D RPA (replication factor A)
D Other NER factors
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
D MutL homologs
D DNA polymerase delta complex
D RPA (replication factor A)
D RFC (replication factor C)
D Other MMR factors
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D MRN(MRX) complex
D BRCA1-core complex
D BRCA1-A complex
D BRCA1-B complex
D BRCA1-C complex
D BRCA complex
D RecA family proteins
D Rad52 family proteins
D Rad54 family proteins
D RecQ family DNA helicases
D Bloom's syndrome complex (BTR)
D RPA (replication factor A)
D Protein phosphatase 4
D AP-5 complex
D SMC5-SMC6 complex
D Other HR factors
C NHEJ (non-homologous end-joining)
D DNA-PK complex
D MRX complex
D DNA Ligase 4 complex
D X-family DNA polymerases
D Other NHEJ factors
C FA (Fanconi anemia) pathway
D FA core complex
D FA core complex binding factors
D Bloom's syndrome complex (BTR)
D FANCD2-I complex
D Downstream FA components
D Other FA pathway factors
C Other DSBR factors
D Protein phosphatase 6
D Ubiquitin ligases
D Others
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
C B-family DNA polymerases
C A-family DNA polymerase
C Rad6 epistasis group
C Other TLS factors
B Check point factors
C Rad9-Hus1-Rad1 complex
C HRAD17(Rad24)-RFC complex
C Rad17-Mec3-Ddc1 complex
C FPC (fork protection complex)
C Triple T complex
C BAG6-UBL4A-GET4 complex
C Other check point factors
B Other factors with a suspected DNA repair function
C DNA polymerases
C Nucleases
C Helicases
C PSO4 complex
C Modulation of nucleotide pools
D EcDH1_3501 mutator MutT protein K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D EcDH1_0065 deoxyuridine 5'-triphosphate nucleotidohydrolase Dut K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
#
AProkaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D EcDH1_2309 methylated-DNA/protein-cysteine methyltransferase K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
D EcDH1_1445 transcriptional regulator, AraC family K10778 ada; AraC family transcriptional regulator, regulatory protein of adaptative response / methylated-DNA-[protein]-cysteine methyltransferase [EC:2.1.1.63]
D EcDH1_2928 Deoxyribodipyrimidine photo-lyase K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]
D EcDH1_1446 alkylated DNA repair protein AlkB K03919 alkB; DNA oxidative demethylase [EC:1.14.11.33]
C BER (base exicision repair)
D DNA glycosylases
E EcDH1_1088 uracil-DNA glycosylase K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E EcDH1_0632 Uracil-DNA glycosylase superfamily K03649 mug; double-stranded uracil-DNA glycosylase [EC:3.2.2.28]
E EcDH1_1589 DNA-3-methyladenine glycosylase II K01247 alkA; DNA-3-methyladenine glycosylase II [EC:3.2.2.21]
E EcDH1_0734 A/G-specific adenine glycosylase K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
E EcDH1_0163 DNA-3-methyladenine glycosylase I K01246 tag; DNA-3-methyladenine glycosylase I [EC:3.2.2.20]
E EcDH1_0070 formamidopyrimidine-DNA glycosylase K10563 mutM; formamidopyrimidine-DNA glycosylase [EC:3.2.2.23 4.2.99.18]
E EcDH1_2922 DNA-(apurinic or apyrimidinic site) lyase K05522 nei; endonuclease VIII [EC:3.2.2.- 4.2.99.18]
E EcDH1_2008 endonuclease III K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
E EcDH1_1893 exodeoxyribonuclease III K01142 E3.1.11.2; exodeoxyribonuclease III [EC:3.1.11.2]
E EcDH1_1499 apurinic endonuclease Apn1 K01151 nfo; deoxyribonuclease IV [EC:3.1.21.2]
E EcDH1_3996 Deoxyribonuclease V K05982 E3.1.21.7; deoxyribonuclease V [EC:3.1.21.7]
D RecJ
E EcDH1_0800 single-stranded-DNA-specific exonuclease RecJ K07462 recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-]
D DNA ligase
E EcDH1_0058 DNA ligase (NAD(+)) K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
E EcDH1_1250 DNA ligase, NAD-dependent K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
D DNA polymerase I
E EcDH1_4123 DNA polymerase I K02335 polA; DNA polymerase I [EC:2.7.7.7]
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E EcDH1_3934 excinuclease ABC, A subunit K03701 uvrA; excinuclease ABC subunit A
E EcDH1_2863 excinuclease ABC, B subunit K03702 uvrB; excinuclease ABC subunit B
E EcDH1_1733 excinuclease ABC, C subunit K03703 uvrC; excinuclease ABC subunit C
E EcDH1_1901 Excinuclease ABC C subunit domain protein K05984 cho; excinuclease Cho [EC:3.1.25.-]
E EcDH1_4166 DNA helicase II K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E EcDH1_4123 DNA polymerase I K02335 polA; DNA polymerase I [EC:2.7.7.7]
E EcDH1_0058 DNA ligase (NAD(+)) K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
E EcDH1_1250 DNA ligase, NAD-dependent K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase complex (RNAP)
F EcDH1_4008 DNA-directed RNA polymerase, beta subunit K03043 rpoB; DNA-directed RNA polymerase subunit beta [EC:2.7.7.6]
F EcDH1_4007 DNA-directed RNA polymerase, beta' subunit K03046 rpoC; DNA-directed RNA polymerase subunit beta' [EC:2.7.7.6]
F EcDH1_0418 DNA-directed RNA polymerase, alpha subunit K03040 rpoA; DNA-directed RNA polymerase subunit alpha [EC:2.7.7.6]
F EcDH1_0056 DNA-directed RNA polymerase, omega subunit K03060 rpoZ; DNA-directed RNA polymerase subunit omega [EC:2.7.7.6]
E TRCF (transcription-repair coupling factor)
F EcDH1_2533 transcription-repair coupling factor K03723 mfd; transcription-repair coupling factor (superfamily II helicase) [EC:5.6.2.4]
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
E EcDH1_0955 DNA mismatch repair protein MutS K03555 mutS; DNA mismatch repair protein MutS
D Molecular matchmaker
E EcDH1_3823 DNA mismatch repair protein MutL K03572 mutL; DNA mismatch repair protein MutL
D Strand discrimination factor
E EcDH1_0859 DNA mismatch repair endonuclease mutH K03573 mutH; DNA mismatch repair protein MutH
D DNA exonucleases
E EcDH1_1646 Exodeoxyribonuclease I K01141 sbcB; exodeoxyribonuclease I [EC:3.1.11.1]
E EcDH1_1159 exodeoxyribonuclease VII, large subunit K03601 xseA; exodeoxyribonuclease VII large subunit [EC:3.1.11.6]
E EcDH1_3187 exodeoxyribonuclease VII, small subunit K03602 xseB; exodeoxyribonuclease VII small subunit [EC:3.1.11.6]
E EcDH1_1798 Exonuclease RNase T and DNA polymerase III K10857 exoX; exodeoxyribonuclease X [EC:3.1.11.-]
D DNA polymerase III holoenzyme
E EcDH1_3419 DNA polymerase III, alpha subunit K02337 dnaE; DNA polymerase III subunit alpha [EC:2.7.7.7]
E EcDH1_0002 DNA polymerase III, beta subunit K02338 dnaN; DNA polymerase III subunit beta [EC:2.7.7.7]
E EcDH1_3738 DNA-directed DNA polymerase K02339 holC; DNA polymerase III subunit chi [EC:2.7.7.7]
E EcDH1_2986 DNA polymerase III, delta subunit K02340 holA; DNA polymerase III subunit delta [EC:2.7.7.7]
E EcDH1_2548 DNA polymerase III, delta prime subunit K02341 holB; DNA polymerase III subunit delta' [EC:2.7.7.7]
E EcDH1_3393 DNA polymerase III, epsilon subunit K02342 dnaQ; DNA polymerase III subunit epsilon [EC:2.7.7.7]
E EcDH1_3140 DNA polymerase III, subunits gamma and tau K02343 dnaX; DNA polymerase III subunit gamma/tau [EC:2.7.7.7]
E EcDH1_3627 DNA polymerase III, psi subunit K02344 holD; DNA polymerase III subunit psi [EC:2.7.7.7]
E EcDH1_1800 DNA polymerase II beta subunit K02345 holE; DNA polymerase III subunit theta [EC:2.7.7.7]
D DNA ligase
E EcDH1_0058 DNA ligase (NAD(+)) K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
E EcDH1_1250 DNA ligase, NAD-dependent K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
D Other MMR factors
E EcDH1_4166 DNA helicase II K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E EcDH1_3933 single-strand binding protein K03111 ssb; single-strand DNA-binding protein
E EcDH1_0326 DNA adenine methylase K06223 dam; DNA adenine methylase [EC:2.1.1.72]
E EcDH1_1689 DNA mismatch endonuclease Vsr K07458 vsr; DNA mismatch endonuclease, patch repair protein [EC:3.1.-.-]
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D RecBC pathway proteins
E EcDH1_0871 exodeoxyribonuclease V, beta subunit K03582 recB; exodeoxyribonuclease V beta subunit [EC:3.1.11.5]
E EcDH1_0869 exodeoxyribonuclease V, gamma subunit K03583 recC; exodeoxyribonuclease V gamma subunit [EC:3.1.11.5]
E EcDH1_0872 exodeoxyribonuclease V, alpha subunit K03581 recD; exodeoxyribonuclease V alpha subunit [EC:3.1.11.5]
E EcDH1_0990 recA protein K03553 recA; recombination protein RecA
E EcDH1_1779 Holliday junction DNA helicase RuvA K03550 ruvA; holliday junction DNA helicase RuvA
E EcDH1_1780 Holliday junction DNA helicase RuvB K03551 ruvB; holliday junction DNA helicase RuvB [EC:5.6.2.4]
E EcDH1_1777 crossover junction endodeoxyribonuclease RuvC K01159 ruvC; crossover junction endodeoxyribonuclease RuvC [EC:3.1.21.10]
E EcDH1_4050 primosomal protein N' K04066 priA; primosomal protein N' (replication factor Y) (superfamily II helicase) [EC:5.6.2.4]
E EcDH1_3792 single-strand binding protein/Primosomal replication protein n K02686 priB; primosomal replication protein N
E EcDH1_3143 Primosomal replication priB and priC K04067 priC; primosomal replication protein N''
E EcDH1_3635 primosomal protein 1 K02317 dnaT; DNA replication protein DnaT
E EcDH1_1646 Exodeoxyribonuclease I K01141 sbcB; exodeoxyribonuclease I [EC:3.1.11.1]
E EcDH1_3212 exonuclease SbcC K03546 sbcC; DNA repair protein SbcC/Rad50
E EcDH1_3211 nuclease SbcCD, D subunit K03547 sbcD; DNA repair protein SbcD/Mre11
D RecFOR pathway proteins
E EcDH1_0990 recA protein K03553 recA; recombination protein RecA
E EcDH1_3609 DNA repair protein RadA K04485 radA; DNA repair protein RadA/Sms
E EcDH1_0003 DNA replication and repair protein RecF K03629 recF; DNA replication and repair protein RecF
E EcDH1_0053 ATP-dependent DNA helicase RecG K03655 recG; ATP-dependent DNA helicase RecG [EC:5.6.2.4]
E EcDH1_0800 single-stranded-DNA-specific exonuclease RecJ K07462 recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-]
E EcDH1_1103 DNA repair protein RecO K03584 recO; DNA repair protein RecO (recombination protein O)
E EcDH1_3138 recombination protein RecR K06187 recR; recombination protein RecR
E EcDH1_1059 DNA repair protein RecN K03631 recN; DNA repair protein RecN (Recombination protein N)
E EcDH1_3215 putative exonuclease RdgC K03554 rdgC; recombination associated protein RdgC
E EcDH1_1779 Holliday junction DNA helicase RuvA K03550 ruvA; holliday junction DNA helicase RuvA
E EcDH1_1780 Holliday junction DNA helicase RuvB K03551 ruvB; holliday junction DNA helicase RuvB [EC:5.6.2.4]
E EcDH1_1777 crossover junction endodeoxyribonuclease RuvC K01159 ruvC; crossover junction endodeoxyribonuclease RuvC [EC:3.1.21.10]
D AddAB pathway proteins
D Other HR factor
E EcDH1_0933 CRISPR-associated protein Cas1 K15342 cas1; CRISP-associated protein Cas1
E EcDH1_1473 type III restriction protein res subunit K19789 radD; DNA repair protein RadD
D Archaeal homologous recombinant proteins
E EcDH1_3212 exonuclease SbcC K03546 sbcC; DNA repair protein SbcC/Rad50
E EcDH1_3211 nuclease SbcCD, D subunit K03547 sbcD; DNA repair protein SbcD/Mre11
E EcDH1_3734 protein of unknown function DUF853 NPT hydrolase putative K06915 herA; DNA double-strand break repair helicase HerA and related ATPase
C NHEJ (non-homologous end-joining)
D Two-component NHEJ DNA repair complex
D SHIIR (short-homology-independent illegitimate recombination)
E Facilitator
F EcDH1_1428 DNA gyrase, A subunit K02469 gyrA; DNA gyrase subunit A [EC:5.6.2.2]
F EcDH1_0004 DNA gyrase, B subunit K02470 gyrB; DNA gyrase subunit B [EC:5.6.2.2]
F EcDH1_2375 DNA topoisomerase I K03168 topA; DNA topoisomerase I [EC:5.6.2.1]
E Supressor
F EcDH1_3994 histone family protein DNA-binding protein K05787 hupA; DNA-binding protein HU-alpha
F EcDH1_3169 histone family protein DNA-binding protein K03530 hupB; DNA-binding protein HU-beta
D SHDIR (short-homology-dependent illegitimate recombination)
E RecET pathway
F EcDH1_2294 exodeoxyribonuclease VIII K10906 recE; exodeoxyribonuclease VIII [EC:3.1.11.-]
F EcDH1_2295 RecT protein K07455 recT; recombination protein RecT
F EcDH1_0800 single-stranded-DNA-specific exonuclease RecJ K07462 recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-]
F EcDH1_1103 DNA repair protein RecO K03584 recO; DNA repair protein RecO (recombination protein O)
F EcDH1_3138 recombination protein RecR K06187 recR; recombination protein RecR
F EcDH1_0058 DNA ligase (NAD(+)) K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
F EcDH1_1250 DNA ligase, NAD-dependent K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
E Facilitator
F EcDH1_0445 transcriptional regulator, Fis family K03557 fis; Fis family transcriptional regulator, factor for inversion stimulation protein
F EcDH1_1930 integration host factor, alpha subunit K04764 ihfA; integration host factor subunit alpha
F EcDH1_2731 integration host factor, beta subunit K05788 ihfB; integration host factor subunit beta
E Supressor
F EcDH1_1646 Exodeoxyribonuclease I K01141 sbcB; exodeoxyribonuclease I [EC:3.1.11.1]
F EcDH1_4157 ATP-dependent DNA helicase, RecQ family K03654 recQ; ATP-dependent DNA helicase RecQ [EC:5.6.2.4]
F EcDH1_3934 excinuclease ABC, A subunit K03701 uvrA; excinuclease ABC subunit A
F EcDH1_2863 excinuclease ABC, B subunit K03702 uvrB; excinuclease ABC subunit B
F EcDH1_2412 histone family protein nucleoid-structuring protein H-NS K03746 hns; DNA-binding protein H-NS
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
D EcDH1_3376 DNA-directed DNA polymerase K02346 dinB; DNA polymerase IV [EC:2.7.7.7]
D EcDH1_2464 DNA-directed DNA polymerase K03502 umuC; DNA polymerase V
D EcDH1_2465 peptidase S24 and S26 domain protein K03503 umuD; DNA polymerase V [EC:3.4.21.-]
C Other SOS response factors
D EcDH1_0990 recA protein K03553 recA; recombination protein RecA
D EcDH1_3950 SOS-response transcriptional repressor, LexA K01356 lexA; repressor LexA [EC:3.4.21.88]
D EcDH1_1059 DNA repair protein RecN K03631 recN; DNA repair protein RecN (Recombination protein N)
D EcDH1_3539 DNA-directed DNA polymerase K02336 polB; DNA polymerase II [EC:2.7.7.7]
D EcDH1_3933 single-strand binding protein K03111 ssb; single-strand DNA-binding protein
D EcDH1_0060 DNA-damage-inducible protein D K14623 dinD; DNA-damage-inducible protein D
D EcDH1_2585 DinI family protein K12149 dinI; DNA-damage-inducible protein I
D EcDH1_0991 regulatory protein RecX K03565 recX; regulatory protein
D EcDH1_0302 putative transposase YhgA family protein K01157 rpnA; recombination-promoting nuclease RpnA [EC:3.1.21.-]
D EcDH1_1351 putative transposase YhgA family protein K24087 rpnB; recombination-promoting nuclease RpnB [EC:3.1.21.-]
D EcDH1_3470 putative transposase YhgA family protein K24088 rpnC; recombination-promoting nuclease RpnC [EC:3.1.21.-]
D EcDH1_1415 putative transposase YhgA family protein K24090 rpnE; recombination-promoting nuclease RpnE
B Other factors with a suspected DNA repair function
C DNA polymerase
C DNA helicases
D EcDH1_4199 ATP-dependent DNA helicase Rep K03656 rep; ATP-dependent DNA helicase Rep [EC:5.6.2.4]
D EcDH1_2681 UvrD/REP helicase K03658 helD; DNA helicase IV [EC:5.6.2.4]
D EcDH1_1835 helicase c2 K03722 dinG; ATP-dependent DNA helicase DinG [EC:5.6.2.3]
D EcDH1_2843 helicase c2 K03722 dinG; ATP-dependent DNA helicase DinG [EC:5.6.2.3]
D EcDH1_1987 DEAD/H associated domain protein K03724 lhr; ATP-dependent helicase Lhr and Lhr-like helicase [EC:5.6.2.6 5.6.2.4]
C Modulation of nucleotide pools
D EcDH1_3501 mutator MutT protein K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D EcDH1_0065 deoxyuridine 5'-triphosphate nucleotidohydrolase Dut K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D EcDH1_1425 ribonucleoside-diphosphate reductase, alpha subunit K00525 E1.17.4.1A; ribonucleoside-diphosphate reductase alpha chain [EC:1.17.4.1]
D EcDH1_1008 ribonucleoside-diphosphate reductase, alpha subunit K00525 E1.17.4.1A; ribonucleoside-diphosphate reductase alpha chain [EC:1.17.4.1]
D EcDH1_1424 Ribonucleoside-diphosphate reductase K00526 E1.17.4.1B; ribonucleoside-diphosphate reductase beta chain [EC:1.17.4.1]
D EcDH1_1007 Ribonucleoside-diphosphate reductase K00526 E1.17.4.1B; ribonucleoside-diphosphate reductase beta chain [EC:1.17.4.1]
C Others
!
#
#[ BRITE | KEGG2 | KEGG ]
#Last updated: March 29, 2024