+F Repair protein KO
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DNA Repair and Recombination Proteins - Eurypyga helias (sunbittern)
%
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AEukaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D 104502911 ALKBH2; alpha-ketoglutarate-dependent dioxygenase alkB homolog 2 K10859 ALKBH2; DNA oxidative demethylase [EC:1.14.11.33]
D 104506279 LOW QUALITY PROTEIN: activating signal cointegrator 1 complex subunit 3-like K18663 ASCC3; activating signal cointegrator complex subunit 3 [EC:5.6.2.4]
D 104515106 deoxyribodipyrimidine photo-lyase-like K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]
C BER (base exicision repair)
D DNA glycosylases
E 104514784 UNG; uracil-DNA glycosylase K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E 104503826 TDG; G/T mismatch-specific thymine DNA glycosylase K20813 TDG; thymine-DNA glycosylase [EC:3.2.2.29]
E 104515072 MUTYH; A/G-specific adenine DNA glycosylase K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
E 104504791 MBD4; LOW QUALITY PROTEIN: methyl-CpG-binding domain protein 4 K10801 MBD4; methyl-CpG-binding domain protein 4 [EC:3.2.2.-]
E 104503177 NEIL2; endonuclease 8-like 2 K10568 NEIL2; endonuclease VIII-like 2 [EC:3.2.2.- 4.2.99.18]
E 104513600 NEIL3; endonuclease 8-like 3 K10569 NEIL3; endonuclease VIII-like 3 [EC:3.2.2.- 4.2.99.18]
E 104506641 NTHL1; endonuclease III-like protein 1 K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
D Long Patch-BER factors
E DNA polymerase delta complex
F 104510869 POLD3; DNA polymerase delta subunit 3 K03504 POLD3; DNA polymerase delta subunit 3
E DNA polymerase epsilon complex
F 104514522 POLE; DNA polymerase epsilon catalytic subunit A K02324 POLE; DNA polymerase epsilon subunit 1 [EC:2.7.7.7]
F 104503975 POLE2; DNA polymerase epsilon subunit 2 K02325 POLE2; DNA polymerase epsilon subunit 2 [EC:2.7.7.7]
F 104504242 POLE3; DNA polymerase epsilon subunit 3 K02326 POLE3; DNA polymerase epsilon subunit 3 [EC:2.7.7.7]
E 104510770 PCNA; proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
E 104502500 FEN1; flap endonuclease 1 K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
D Short Patch-BER factors
E 104512716 POLB; DNA polymerase beta K02330 POLB; DNA polymerase beta [EC:2.7.7.7 4.2.99.-]
E 104506935 LIG3; LOW QUALITY PROTEIN: DNA ligase 3 K10776 LIG3; DNA ligase 3 [EC:6.5.1.1]
D Other BER factors
E 104506919 TDP1; tyrosyl-DNA phosphodiesterase 1 K10862 TDP1; tyrosyl-DNA phosphodiesterase 1 [EC:3.1.4.-]
E 104504971 APLF; aprataxin and PNK-like factor K13295 APLF; aprataxin and PNK-like factor [EC:3.1.-.-]
E 104513944 HMGB1; high mobility group protein B1 K10802 HMGB1; high mobility group protein B1
E 104511459 POLL; DNA polymerase lambda K03512 POLL; DNA polymerase lambda [EC:2.7.7.7 4.2.99.-]
E 104505512 PARP1; poly [ADP-ribose] polymerase 1 K24070 PARP1; poly [ADP-ribose] polymerase 1 [EC:2.4.2.30]
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E XPC-HR23B-CETN2 complex
F 104503274 XPC; DNA repair protein complementing XP-C cells K10838 XPC; xeroderma pigmentosum group C-complementing protein
F 104504229 RAD23B; UV excision repair protein RAD23 homolog B K10839 RAD23; UV excision repair protein RAD23
F 104514888 LOW QUALITY PROTEIN: centrin-2-like K10840 CETN2; centrin-2
E Cul4-DDB2 complex
F 104517283 CUL4A; LOW QUALITY PROTEIN: cullin-4A K10609 CUL4; cullin 4
F 104509752 CUL4B; cullin-4B K10609 CUL4; cullin 4
F 104509593 DNA damage-binding protein 1-like K10610 DDB1; DNA damage-binding protein 1
F 104509419 DDB2; DNA damage-binding protein 2 K10140 DDB2; DNA damage-binding protein 2
E NER4 complex
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase II complex
F 104512337 POLR2B; DNA-directed RNA polymerase II subunit RPB2 K03010 RPB2; DNA-directed RNA polymerase II subunit RPB2 [EC:2.7.7.6]
F 104502930 POLR2C; DNA-directed RNA polymerase II subunit RPB3 K03011 RPB3; DNA-directed RNA polymerase II subunit RPB3
F 104504688 POLR2D; DNA-directed RNA polymerase II subunit RPB4 K03012 RPB4; DNA-directed RNA polymerase II subunit RPB4
F 104509853 POLR2F; DNA-directed RNA polymerases I, II, and III subunit RPABC2 K03014 RPABC2; DNA-directed RNA polymerases I, II, and III subunit RPABC2
F 104503116 POLR2H; DNA-directed RNA polymerases I, II, and III subunit RPABC3 isoform X1 K03016 RPABC3; DNA-directed RNA polymerases I, II, and III subunit RPABC3
F 104504875 POLR2K; DNA-directed RNA polymerases I, II, and III subunit RPABC4 K03009 RPABC4; DNA-directed RNA polymerases I, II, and III subunit RPABC4
E Cul4-CSA complex
F 104517283 CUL4A; LOW QUALITY PROTEIN: cullin-4A K10609 CUL4; cullin 4
F 104509752 CUL4B; cullin-4B K10609 CUL4; cullin 4
F 104509593 DNA damage-binding protein 1-like K10610 DDB1; DNA damage-binding protein 1
E Other TCR factor
F 104507691 DNA excision repair protein ERCC-6-like K10841 ERCC6; DNA excision repair protein ERCC-6
F 104506241 DNA excision repair protein ERCC-6-like K10841 ERCC6; DNA excision repair protein ERCC-6
F 104517353 UVSSA; UV-stimulated scaffold protein A K23720 UVSSA; UV-stimulated scaffold protein A
D TFIIH complex
E 104516881 ERCC3; TFIIH basal transcription factor complex helicase XPB subunit K10843 ERCC3; DNA excision repair protein ERCC-3 [EC:5.6.2.4]
E 104511879 GTF2H1; general transcription factor IIH subunit 1 K03141 TFIIH1; transcription initiation factor TFIIH subunit 1
E 104517012 GTF2H3; general transcription factor IIH subunit 3 K03143 TFIIH3; transcription initiation factor TFIIH subunit 3
E 104510551 GTF2H5; general transcription factor IIH subunit 5 K10845 TTDA; TFIIH basal transcription factor complex TTD-A subunit
E 104507118 cyclin-dependent kinase 7-like K02202 CDK7; cyclin-dependent kinase 7 [EC:2.7.11.22 2.7.11.23]
E 104510189 CCNH; cyclin-H K06634 CCNH; cyclin H
E 104514415 MNAT1; CDK-activating kinase assembly factor MAT1 K10842 MNAT1; CDK-activating kinase assembly factor MAT1
D RPA (replication factor A)
E 104503448 RPA1; replication protein A 70 kDa DNA-binding subunit K07466 RFA1; replication factor A1
E 104509468 RPA3; replication protein A 14 kDa subunit K10740 RPA3; replication factor A3
D Other NER factors
E 104502512 ERCC4; DNA repair endonuclease XPF K10848 ERCC4; DNA excision repair protein ERCC-4 [EC:3.1.-.-]
E 104513593 ERCC5; DNA repair protein complementing XP-G cells K10846 ERCC5; DNA excision repair protein ERCC-5
E 104507378 MMS19; MMS19 nucleotide excision repair protein homolog K15075 MET18; DNA repair/transcription protein MET18/MMS19
E 104512368 cullin-3 K03869 CUL3; cullin 3
E 104510014 CUL5; cullin-5 K10612 CUL5; cullin 5
E 104506447 TCEB1; transcription elongation factor B polypeptide 1 K03872 ELOC; elongin-C
E 104516416 TCEB2; transcription elongation factor B polypeptide 2 K03873 ELOB; elongin-B
E 104513302 transcription elongation factor B polypeptide 3-like K15076 ELOA; elongin-A
E 104514858 TCEB3; transcription elongation factor B polypeptide 3 K15076 ELOA; elongin-A
E 104508119 ubiquitin-associated protein 2-like K26545 UBAP2; ubiquitin-associated protein 2
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
E 104503248 MSH2; DNA mismatch repair protein Msh2 K08735 MSH2; DNA mismatch repair protein MSH2
E 104514933 MSH6; LOW QUALITY PROTEIN: DNA mismatch repair protein Msh6 K08737 MSH6; DNA mismatch repair protein MSH6
D MutL homologs
E 104503635 PMS1; PMS1 protein homolog 1 isoform X1 K10864 PMS1; DNA mismatch repair protein PMS1
E 104513112 MLH1; DNA mismatch repair protein Mlh1 K08734 MLH1; DNA mismatch repair protein MLH1
E 104503676 LOW QUALITY PROTEIN: mismatch repair endonuclease PMS2-like K10858 PMS2; DNA mismatch repair protein PMS2
E 104504272 MLH3; DNA mismatch repair protein Mlh3 K08739 MLH3; DNA mismatch repair protein MLH3
D DNA polymerase delta complex
E 104510869 POLD3; DNA polymerase delta subunit 3 K03504 POLD3; DNA polymerase delta subunit 3
D RPA (replication factor A)
E 104503448 RPA1; replication protein A 70 kDa DNA-binding subunit K07466 RFA1; replication factor A1
E 104509468 RPA3; replication protein A 14 kDa subunit K10740 RPA3; replication factor A3
D RFC (replication factor C)
E 104516352 RFC1; replication factor C subunit 1 K10754 RFC1; replication factor C subunit 1
E 104509462 RFC4; replication factor C subunit 4 K10755 RFC2_4; replication factor C subunit 2/4
E 104511606 RFC2; replication factor C subunit 2 K10755 RFC2_4; replication factor C subunit 2/4
E 104513581 RFC3; replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
E 104515981 RFC5; replication factor C subunit 5 K10756 RFC3_5; replication factor C subunit 3/5
D Other MMR factors
E 104510770 PCNA; proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
E 104517363 EXO1; exonuclease 1 K10746 EXO1; exonuclease 1 [EC:3.1.-.-]
E 104513944 HMGB1; high mobility group protein B1 K10802 HMGB1; high mobility group protein B1
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D MRN(MRX) complex
E 104514893 MRE11A; double-strand break repair protein MRE11A K10865 MRE11; double-strand break repair protein MRE11
E 104506346 RAD50; DNA repair protein RAD50 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
E 104510866 nibrin-like K10867 NBN; nibrin
D BRCA1-core complex
E 104513407 BRCA1; LOW QUALITY PROTEIN: breast cancer type 1 susceptibility protein K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 104506317 BARD1; LOW QUALITY PROTEIN: BRCA1-associated RING domain protein 1 K10683 BARD1; BRCA1-associated RING domain protein 1
D BRCA1-A complex
E 104513407 BRCA1; LOW QUALITY PROTEIN: breast cancer type 1 susceptibility protein K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 104502863 FAM175A; BRCA1-A complex subunit Abraxas K20774 FAM175A; BRCA1-A complex subunit Abraxas
E 104505498 UIMC1; BRCA1-A complex subunit RAP80 K20775 UIMC1; BRCA1-A complex subunit RAP80
E 104512681 BRE; BRCA1-A complex subunit BRE K12173 BRE; BRCA1-A complex subunit BRE
E 104504204 BRCC3; lys-63-specific deubiquitinase BRCC36 K11864 BRCC3; BRCA1/BRCA2-containing complex subunit 3 [EC:3.4.19.-]
D BRCA1-B complex
E 104513407 BRCA1; LOW QUALITY PROTEIN: breast cancer type 1 susceptibility protein K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 104502531 BRIP1; Fanconi anemia group J protein K15362 BRIP1; fanconi anemia group J protein [EC:5.6.2.3]
E 104505357 TOPBP1; LOW QUALITY PROTEIN: DNA topoisomerase 2-binding protein 1 K10728 TOPBP1; topoisomerase (DNA) II binding protein 1
D BRCA1-C complex
E 104513407 BRCA1; LOW QUALITY PROTEIN: breast cancer type 1 susceptibility protein K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 104512936 RBBP8; DNA endonuclease RBBP8 K20773 RBBP8; DNA endonuclease RBBP8 [EC:3.1.-.-]
E 104514893 MRE11A; double-strand break repair protein MRE11A K10865 MRE11; double-strand break repair protein MRE11
E 104506346 RAD50; DNA repair protein RAD50 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
E 104510866 nibrin-like K10867 NBN; nibrin
D BRCA complex
E 104513407 BRCA1; LOW QUALITY PROTEIN: breast cancer type 1 susceptibility protein K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 104502866 BRCA2; breast cancer type 2 susceptibility protein K08775 BRCA2; breast cancer 2 susceptibility protein
E 104504009 PALB2; partner and localizer of BRCA2 K10897 PALB2; partner and localizer of BRCA2
E 104503446 RAD51; DNA repair protein RAD51 homolog 1 isoform X1 K04482 RAD51; DNA repair protein RAD51
D RecA family proteins
E 104503446 RAD51; DNA repair protein RAD51 homolog 1 isoform X1 K04482 RAD51; DNA repair protein RAD51
E 104510083 RAD51C; DNA repair protein RAD51 homolog 3 K10870 RAD51L2; RAD51-like protein 2
E 104505657 RAD51D; DNA repair protein RAD51 homolog 4 K10871 RAD51L3; RAD51-like protein 3
E 104506670 XRCC2; DNA repair protein XRCC2 K10879 XRCC2; DNA-repair protein XRCC2
E 104503320 XRCC3; DNA repair protein XRCC3 K10880 XRCC3; DNA-repair protein XRCC3
D Rad52 family proteins
D Rad54 family proteins
E 104507707 RAD54L; DNA repair and recombination protein RAD54-like K10875 RAD54L; DNA repair and recombination protein RAD54 and RAD54-like protein [EC:5.6.2.-]
E 104503135 RAD54L2; helicase ARIP4 K10876 RAD54L2; RAD54-like protein 2 [EC:5.6.2.-]
E 104516454 RAD54B; DNA repair and recombination protein RAD54B K10877 RAD54B; DNA repair and recombination protein RAD54B [EC:5.6.2.-]
D RecQ family DNA helicases
E 104505993 RECQL; ATP-dependent DNA helicase Q1 K10899 RECQL; ATP-dependent DNA helicase Q1 [EC:5.6.2.4]
E 104503756 WRN; LOW QUALITY PROTEIN: Werner syndrome ATP-dependent helicase K10900 WRN; werner syndrome ATP-dependent helicase [EC:5.6.2.4]
E 104512752 LOW QUALITY PROTEIN: ATP-dependent DNA helicase Q5-like K10902 RECQL5; ATP-dependent DNA helicase Q5 [EC:5.6.2.4]
D Bloom's syndrome complex (BTR)
E 104503380 TOP3B; DNA topoisomerase 3-beta-1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 104503180 TOP3A; DNA topoisomerase 3-alpha K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 104515486 RMI1; recQ-mediated genome instability protein 1 K10990 RMI1; RecQ-mediated genome instability protein 1
D RPA (replication factor A)
E 104503448 RPA1; replication protein A 70 kDa DNA-binding subunit K07466 RFA1; replication factor A1
E 104509468 RPA3; replication protein A 14 kDa subunit K10740 RPA3; replication factor A3
D Protein phosphatase 4
E 104512357 serine/threonine-protein phosphatase 4 regulatory subunit 1-like K15424 PPP4R1; serine/threonine-protein phosphatase 4 regulatory subunit 1
E 104507817 PPP4R1; serine/threonine-protein phosphatase 4 regulatory subunit 1 K15424 PPP4R1; serine/threonine-protein phosphatase 4 regulatory subunit 1
E 104511065 PPP4R2; serine/threonine-protein phosphatase 4 regulatory subunit 2 K15425 PPP4R2; serine/threonine-protein phosphatase 4 regulatory subunit 2
E 104510070 SMEK1; serine/threonine-protein phosphatase 4 regulatory subunit 3A K17491 SMEK; protein phosphatase 4 regulatory subunit 3
E 104511517 SMEK2; LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 4 regulatory subunit 3B K17491 SMEK; protein phosphatase 4 regulatory subunit 3
E 104517271 LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 4 regulatory subunit 4-like K15426 PPP4R4; serine/threonine-protein phosphatase 4 regulatory subunit 4
D AP-5 complex
E 104512068 AP5M1; AP-5 complex subunit mu-1 K19023 AP5M1; AP-5 complex subunit mu-1
E 104515716 AP5Z1; AP-5 complex subunit zeta-1 K19025 AP5Z1; AP-5 complex subunit zeta-1
D SMC5-SMC6 complex
E 104514163 SMC6; structural maintenance of chromosomes protein 6 K22804 SMC6; structural maintenance of chromosomes protein 6
E 104512907 FAM84A; LOW QUALITY PROTEIN: protein FAM84A K22805 FAM84A; protein FAM84A
E 104508519 NSMCE1; non-structural maintenance of chromosomes element 1 homolog K22817 NSMCE1; non-structural maintenance of chromosomes element 1 [EC:2.3.2.27]
E 104506512 NSMCE2; E3 SUMO-protein ligase NSE2 K22756 NSMCE2; E3 SUMO-protein ligase NSE2 [EC:2.3.2.-]
E 104514133 NSMCE4A; non-structural maintenance of chromosomes element 4 homolog A K22825 NSMCE4; non-structural maintenance of chromosomes element 4
E 104507366 ANKRD32; ankyrin repeat domain-containing protein 32 K26126 SLF1; SMC5-SMC6 complex localization factor protein 1
E 104507843 FAM178A; protein FAM178A K26127 SLF2; SMC5-SMC6 complex localization factor protein 2
D Other HR factors
E 104510147 EME1; crossover junction endonuclease EME1 K10882 EME1; crossover junction endonuclease EME1 [EC:3.1.22.-]
E 104515246 EME2; probable crossover junction endonuclease EME2 K10883 EME2; crossover junction endonuclease EME2
E 104509877 EXD2; exonuclease 3'-5' domain-containing protein 2 K20777 EXD2; exonuclease 3'-5' domain-containing protein 2 [EC:3.1.11.1]
E 104512922 SHFM1; 26S proteasome complex subunit DSS1 K10881 SHFM1; 26 proteasome complex subunit DSS1
E 104503050 SWI5; DNA repair protein SWI5 homolog K10991 SWI5; DNA repair protein Swi5/Sae3
E 104516278 SFR1; swi5-dependent recombination DNA repair protein 1 homolog K10992 SFR1; Swi5-dependent recombination DNA repair protein 1
E 104511683 SLX4; structure-specific endonuclease subunit SLX4 K10484 BTBD12; structure-specific endonuclease subunit SLX4 (BTB/POZ domain-containing protein 12)
E 104514637 flap endonuclease GEN homolog 1-like K15338 GEN1; holliday junction resolvase GEN1/YEN1 [EC:3.1.-.-]
E 104503044 SPG11; spatacsin K19026 SPG11; spatacsin
E 104505232 RAD51AP1; RAD51-associated protein 1 K20778 RAD51AP1; RAD51-associated protein 1
E 104515445 MORF4L1; mortality factor 4-like protein 1 K11339 MORF4L1; mortality factor 4-like protein 1
E 104513992 SAMHD1; deoxynucleoside triphosphate triphosphohydrolase SAMHD1 K22544 SAMHD1; deoxynucleoside triphosphate triphosphohydrolase SAMHD1 [EC:3.1.5.-]
E 104513934 FIGNL1; fidgetin-like protein 1 K22766 FIGNL1; fidgetin-like protein 1 [EC:5.6.2.-]
E 104504241 FAM84B; protein FAM84B K22810 FAM84B; protein FAM84B
E 104502903 BRAT1; BRCA1-associated ATM activator 1 K23112 BRAT1; BRCA1-associated ATM activator 1
E 104517396 protein C21orf2 K23456 CFAP410; cilla- and flagella-associated protein
E 104509250 ZSWIM7; zinc finger SWIM domain-containing protein 7 K25770 ZSWIM7; zinc finger SWIM domain-containing protein 7
E 104513105 protein EMSY isoform X1 K25790 EMSY; BRCA2-interacting transcriptional repressor EMSY
E 104513491 HSF2BP; LOW QUALITY PROTEIN: heat shock factor 2-binding protein K25791 HSF2BP; heat shock factor 2-binding protein
E 104511320 MMS22L; protein MMS22-like K26125 MMS22L; protein MMS22-like
E 104508646 BOD1L1; biorientation of chromosomes in cell division protein 1-like 1 K27262 BOD1L1; biorientation of chromosomes in cell division protein 1-like 1
E 104515828 PARPBP; PCNA-interacting partner K27412 PARPBP; PCNA-interacting partner
C NHEJ (non-homologous end-joining)
D DNA-PK complex
E 104502787 XRCC6; X-ray repair cross-complementing protein 6 K10884 XRCC6; ATP-dependent DNA helicase 2 subunit 1
E 104505905 XRCC5; X-ray repair cross-complementing protein 5 K10885 XRCC5; ATP-dependent DNA helicase 2 subunit 2
E 104514897 PRKDC; DNA-dependent protein kinase catalytic subunit K06642 PRKDC; DNA-dependent protein kinase catalytic subunit [EC:2.7.11.1]
D MRX complex
E 104514893 MRE11A; double-strand break repair protein MRE11A K10865 MRE11; double-strand break repair protein MRE11
E 104506346 RAD50; DNA repair protein RAD50 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
D DNA Ligase 4 complex
E 104512293 LIG4; DNA ligase 4 K10777 LIG4; DNA ligase 4 [EC:6.5.1.1]
E 104513542 XRCC4; DNA repair protein XRCC4 K10886 XRCC4; DNA-repair protein XRCC4
D X-family DNA polymerases
E 104511459 POLL; DNA polymerase lambda K03512 POLL; DNA polymerase lambda [EC:2.7.7.7 4.2.99.-]
E 104514514 DNTT; DNA nucleotidylexotransferase K00977 DNTT; DNA nucleotidylexotransferase [EC:2.7.7.31]
E 104512716 POLB; DNA polymerase beta K02330 POLB; DNA polymerase beta [EC:2.7.7.7 4.2.99.-]
D Other NHEJ factors
E 104504971 APLF; aprataxin and PNK-like factor K13295 APLF; aprataxin and PNK-like factor [EC:3.1.-.-]
E 104502584 DCLRE1C; protein artemis K10887 DCLRE1C; DNA cross-link repair 1C protein [EC:3.1.-.-]
E 104508089 TDP2; tyrosyl-DNA phosphodiesterase 2 K19619 TDP2; tyrosyl-DNA phosphodiesterase 2 [EC:3.1.4.-]
E 104509345 SMCHD1; structural maintenance of chromosomes flexible hinge domain-containing protein 1 K23113 SMCHD1; structural maintenance of chromosomes flexible hinge domain-containing protein 1
E 104507421 PWWP domain-containing protein MUM1 K23386 PWWP3; PWWP domain-containing DNA repair factor 3
E 104511187 JMJD8; jmjC domain-containing protein 8 K25792 JMJD8; jumonji domain-containing protein 8
E 104506646 uncharacterized protein C20orf196 homolog K26128 SHLD1; shieldin complex subunit 1
E 104503537 FAM35A; protein FAM35A K26129 SHLD2; shieldin complex subunit 2
C FA (Fanconi anemia) pathway
D FA core complex
E 104513955 FANCA; LOW QUALITY PROTEIN: Fanconi anemia group A protein K10888 FANCA; fanconi anemia group A protein
E 104515302 FANCB; Fanconi anemia group B protein K10889 FANCB; fanconi anemia group B protein
E 104506848 FANCE; Fanconi anemia group E protein K10892 FANCE; fanconi anemia group E protein
E 104516814 FANCG; Fanconi anemia group G protein K10894 FANCG; fanconi anemia group G protein
E 104503242 FANCL; E3 ubiquitin-protein ligase FANCL K10606 FANCL; E3 ubiquitin-protein ligase FANCL [EC:2.3.2.27]
E 104503713 Fanconi anemia-associated protein of 24 kDa K10898 FAAP24; fanconi anemia-associated protein
D FA core complex binding factors
E 104503793 centromere protein S-like K11511 APITD1; centromere protein S
E 104512479 UBE2T; ubiquitin-conjugating enzyme E2 T K13960 UBE2T; ubiquitin-conjugating enzyme E2 T [EC:2.3.2.23]
D Bloom's syndrome complex (BTR)
E 104503380 TOP3B; DNA topoisomerase 3-beta-1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 104503180 TOP3A; DNA topoisomerase 3-alpha K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 104515486 RMI1; recQ-mediated genome instability protein 1 K10990 RMI1; RecQ-mediated genome instability protein 1
D FANCD2-I complex
E 104502546 FANCD2; Fanconi anemia group D2 protein K10891 FANCD2; fanconi anemia group D2 protein
E 104511699 FANCI; Fanconi anemia group I protein K10895 FANCI; fanconi anemia group I protein
D Downstream FA components
E 104513407 BRCA1; LOW QUALITY PROTEIN: breast cancer type 1 susceptibility protein K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 104502866 BRCA2; breast cancer type 2 susceptibility protein K08775 BRCA2; breast cancer 2 susceptibility protein
E 104502531 BRIP1; Fanconi anemia group J protein K15362 BRIP1; fanconi anemia group J protein [EC:5.6.2.3]
E 104504009 PALB2; partner and localizer of BRCA2 K10897 PALB2; partner and localizer of BRCA2
D Other FA pathway factors
E 104507922 FAN1; fanconi-associated nuclease 1 K15363 FAN1; fanconi-associated nuclease 1 [EC:3.1.21.- 3.1.4.1]
E 104503446 RAD51; DNA repair protein RAD51 homolog 1 isoform X1 K04482 RAD51; DNA repair protein RAD51
E 104510083 RAD51C; DNA repair protein RAD51 homolog 3 K10870 RAD51L2; RAD51-like protein 2
E 104504165 TELO2; telomere length regulation protein TEL2 homolog K11137 TELO2; telomere length regulation protein
E 104509011 USP1; ubiquitin carboxyl-terminal hydrolase 1 K11832 USP1; ubiquitin carboxyl-terminal hydrolase 1 [EC:3.4.19.12]
E 104503201 WDR48; WD repeat-containing protein 48 K15361 WDR48; WD repeat-containing protein 48
C Other DSBR factors
D Protein phosphatase 6
E 104516216 PPP6C; serine/threonine-protein phosphatase 6 catalytic subunit K15498 PPP6C; serine/threonine-protein phosphatase 6 catalytic subunit [EC:3.1.3.16]
E 104512567 PPP6R3; serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X1 K15501 PPP6R3; serine/threonine-protein phosphatase 6 regulatory subunit 3
E 104511171 ANKRD44; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B K15503 ANKRD44; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B
D Ubiquitin ligases
E 104505530 RNF8; E3 ubiquitin-protein ligase RNF8 K10667 RNF8; E3 ubiquitin-protein ligase RNF8 [EC:2.3.2.27]
E 104511029 RNF168; E3 ubiquitin-protein ligase RNF168 K20779 RNF168; E3 ubiquitin-protein ligase RNF168 [EC:2.3.2.31]
E 104516462 RNF169; LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase RNF169 K20805 RNF169; E3 ubiquitin-protein ligase RNF169 [EC:2.3.2.31]
E 104502956 HERC2; E3 ubiquitin-protein ligase HERC2 K10595 HERC2; E3 ubiquitin-protein ligase HERC2 [EC:2.3.2.26]
D Others
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
D 104510500 POLH; LOW QUALITY PROTEIN: DNA polymerase eta K03509 POLH; DNA polymerase eta [EC:2.7.7.7]
D 104514803 POLI; DNA polymerase iota K03510 POLI; DNA polymerase iota [EC:2.7.7.7]
D 104502910 DNA polymerase kappa-like K03511 POLK; DNA polymerase kappa [EC:2.7.7.7]
D 104508944 REV1; DNA repair protein REV1 isoform X1 K03515 REV1; DNA repair protein REV1 [EC:2.7.7.-]
C B-family DNA polymerases
D 104510909 LOW QUALITY PROTEIN: DNA polymerase zeta catalytic subunit-like K02350 REV3L; DNA polymerase zeta [EC:2.7.7.7]
C A-family DNA polymerase
D 104504394 POLN; DNA polymerase nu K16618 POLN; DNA polymerase nu [EC:2.7.7.7]
C Rad6 epistasis group
D 104510854 ubiquitin-conjugating enzyme E2 A K10573 UBE2A; ubiquitin-conjugating enzyme E2 A [EC:2.3.2.23]
D 104504424 ubiquitin-conjugating enzyme E2 B K10574 UBE2B; ubiquitin-conjugating enzyme E2 B [EC:2.3.2.23]
D 104504602 RAD18; E3 ubiquitin-protein ligase RAD18 K10627 RAD18; E3 ubiquitin-protein ligase RAD18 [EC:2.3.2.27]
D 104513775 UBE2V1; ubiquitin-conjugating enzyme E2 variant 1 K10704 UBE2V; ubiquitin-conjugating enzyme E2 variant
D 104504996 UBE2V2; ubiquitin-conjugating enzyme E2 variant 2 K10704 UBE2V; ubiquitin-conjugating enzyme E2 variant
D 104511730 LOW QUALITY PROTEIN: ubiquitin-conjugating enzyme E2 N-like K10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23]
C Other TLS factors
D 104510770 PCNA; proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
D 104515828 PARPBP; PCNA-interacting partner K27412 PARPBP; PCNA-interacting partner
D 104503505 SPRTN; sprT-like domain-containing protein Spartan K24051 SPRTN; SprT-like domain-contaning protein Spartan
D 104505582 ACRC; acidic repeat-containing protein K26957 GCNA; germ cell nuclear acidic protein
B Check point factors
C Rad9-Hus1-Rad1 complex
D 104502722 HUS1; checkpoint protein HUS1 K10903 HUS1; HUS1 checkpoint protein
D 104514947 RAD1; cell cycle checkpoint protein RAD1 K02830 HRAD1; cell cycle checkpoint protein [EC:3.1.11.2]
C HRAD17(Rad24)-RFC complex
D 104513019 RAD17; cell cycle checkpoint protein RAD17 K06662 HRAD17; cell cycle checkpoint protein
D 104509462 RFC4; replication factor C subunit 4 K10755 RFC2_4; replication factor C subunit 2/4
D 104511606 RFC2; replication factor C subunit 2 K10755 RFC2_4; replication factor C subunit 2/4
D 104513581 RFC3; replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
D 104515981 RFC5; replication factor C subunit 5 K10756 RFC3_5; replication factor C subunit 3/5
C Rad17-Mec3-Ddc1 complex
D 104514947 RAD1; cell cycle checkpoint protein RAD1 K02830 HRAD1; cell cycle checkpoint protein [EC:3.1.11.2]
C FPC (fork protection complex)
D 104507417 TIPIN; TIMELESS-interacting protein K10998 TIPIN; replication fork protection complex subunit TIPIN/Csm3/Swi3
D 104515150 CLSPN; claspin K25773 CLSPN; claspin
C Triple T complex
D 104504165 TELO2; telomere length regulation protein TEL2 homolog K11137 TELO2; telomere length regulation protein
D 104508780 TTI1; TELO2-interacting protein 1 homolog K20403 TTI1; TELO2-interacting protein 1
D 104505385 TTI2; TELO2-interacting protein 2 K23115 TTI2; TELO2-interacting protein 2
C BAG6-UBL4A-GET4 complex
D 104516015 GET4; Golgi to ER traffic protein 4 homolog K23387 GET4; golgi to ER traffic protein 4
C Other check point factors
D 104507358 ATR; LOW QUALITY PROTEIN: serine/threonine-protein kinase ATR K06640 ATR; serine/threonine-protein kinase ATR [EC:2.7.11.1]
D 104517183 ATRIP; LOW QUALITY PROTEIN: ATR-interacting protein K10905 ATRIP; ATR interacting protein
D 104517007 CHEK2; serine/threonine-protein kinase Chk2 K06641 CHEK2; serine/threonine-protein kinase CHEK2 [EC:2.7.11.1]
D 104510285 CDC25A; M-phase inducer phosphatase 1 K06645 CDC25A; M-phase inducer phosphatase 1 [EC:3.1.3.48]
D 104504603 YWHAB; 14-3-3 protein beta/alpha K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
D 104504328 14-3-3 protein theta K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
D 104516883 YWHAZ; 14-3-3 protein zeta/delta K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
D 104505692 YWHAH; 14-3-3 protein eta K16198 YWHAG_H; 14-3-3 protein gamma/eta
D 104516283 14-3-3 protein gamma K16198 YWHAG_H; 14-3-3 protein gamma/eta
D 104511576 YWHAE; 14-3-3 protein epsilon K06630 YWHAE; 14-3-3 protein epsilon
D 104511332 NAV2; LOW QUALITY PROTEIN: neuron navigator 2 K19483 NAV2; neuron navigator 2 [EC:5.6.2.4]
D 104503876 WEE2; wee1-like protein kinase 2 K06632 WEE1; wee1-like protein kinase [EC:2.7.11.1]
D 104506331 WEE1; wee1-like protein kinase K06632 WEE1; wee1-like protein kinase [EC:2.7.11.1]
D 104502518 PER2; period circadian protein homolog 2 K02633 PER2; period circadian protein 2
D 104503279 PER3; period circadian protein homolog 3 K21945 PER3; period circadian protein 3
D 104510676 PLS3; plastin-3 isoform X1 K17336 PLS3; plastin-3
D 104508448 apoptosis-enhancing nuclease-like K18340 AEN; apoptosis-enhancing nuclease [EC:3.1.-.-]
D 104515962 PLK3; serine/threonine-protein kinase PLK3 K08862 PLK3; polo-like kinase 3 [EC:2.7.11.21]
D 104514260 serine/threonine-protein kinase Nek1-like K08857 NEK1_4_5; serine/threonine-protein kinase Nek1/4/5 [EC:2.7.11.1]
D 104514452 NEK4; LOW QUALITY PROTEIN: serine/threonine-protein kinase Nek4 K08857 NEK1_4_5; serine/threonine-protein kinase Nek1/4/5 [EC:2.7.11.1]
D 104509784 NEK5; serine/threonine-protein kinase Nek5 K08857 NEK1_4_5; serine/threonine-protein kinase Nek1/4/5 [EC:2.7.11.1]
D 104514952 serine/threonine-protein kinase Nek10-like K20879 NEK10; serine/threonine-protein kinase Nek10 [EC:2.7.11.1]
D 104517128 NEK11; serine/threonine-protein kinase Nek11 K20880 NEK11; serine/threonine-protein kinase Nek11 [EC:2.7.11.1]
D 104505745 DONSON; protein downstream neighbor of Son K22422 DONSON; protein downstream neighbor of Son
D 104509030 KANK1; LOW QUALITY PROTEIN: KN motif and ankyrin repeat domain-containing protein 1 K22808 KANK; KN motif and ankyrin repeat domain-containing protein
D 104511536 LOW QUALITY PROTEIN: KN motif and ankyrin repeat domain-containing protein 3-like K22808 KANK; KN motif and ankyrin repeat domain-containing protein
D 104506726 KANK4; LOW QUALITY PROTEIN: KN motif and ankyrin repeat domain-containing protein 4 K22808 KANK; KN motif and ankyrin repeat domain-containing protein
D 104516678 schlafen family member 11-like K24458 SLFN11; schlafen family member 11 [EC:3.6.-.-]
D 104516169 CHMP4C; charged multivesicular body protein 4c K24782 CHMP4C; charged multivesicular body protein 4C
D 104513617 vacuolar protein sorting-associated protein 4B K12196 VPS4; vacuolar protein-sorting-associated protein 4
D 104508766 ZFYVE19; abscission/NoCut checkpoint regulator K24778 ZFYVE19; abscission/NoCut checkpoint regulator
D 104505144 SDE2; protein SDE2 homolog K25059 SDE2; replication stress response regulator SDE2
B Other factors with a suspected DNA repair function
C DNA polymerases
D 104517164 POLQ; DNA polymerase theta K02349 POLQ; DNA polymerase theta [EC:2.7.7.7]
D 104506978 MYBBP1A; myb-binding protein 1A K02331 POL5; DNA polymerase phi [EC:2.7.7.7]
D 104515766 PRIMPOL; LOW QUALITY PROTEIN: DNA-directed primase/polymerase protein K22761 PRIMPOL; DNA-directed primase/polymerase protein [EC:2.7.7.102 2.7.7.7]
C Nucleases
D 104510577 DCLRE1A; DNA cross-link repair 1A protein K15340 DCLRE1A; DNA cross-link repair 1A protein
D 104517218 DCLRE1B; 5' exonuclease Apollo K15341 DCLRE1B; DNA cross-link repair 1B protein [EC:3.1.-.-]
D 104510216 ENDOV; endonuclease V K21813 ENDOV; endonuclease V [EC:3.1.26.-]
D 104511338 ZRANB3; DNA annealing helicase and endonuclease ZRANB3 K25861 ZRANB3; DNA annealing helicase and endonuclease ZRANB3 [EC:5.6.2.- 3.1.-.-]
C Helicases
D 104508577 HELQ; helicase POLQ-like K19178 HELQ; POLQ-like helicase [EC:5.6.2.4]
C PSO4 complex
D 104512514 CDC5L; cell division cycle 5-like protein K12860 CDC5L; pre-mRNA-splicing factor CDC5/CEF1
D 104502839 BCAS2; pre-mRNA-splicing factor SPF27 K12861 BCAS2; pre-mRNA-splicing factor SPF27
D 104503397 PLRG1; pleiotropic regulator 1 K12862 PLRG1; pleiotropic regulator 1
C Modulation of nucleotide pools
D 104514829 NUDT1; 7,8-dihydro-8-oxoguanine triphosphatase K17816 NUDT1; 8-oxo-dGTP diphosphatase / 2-hydroxy-dATP diphosphatase [EC:3.6.1.55 3.6.1.56]
D 104517300 DUT; deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 104510119 RRM2; ribonucleoside-diphosphate reductase subunit M2 K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]
D 104511070 RRM2B; ribonucleoside-diphosphate reductase subunit M2 B K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]
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AProkaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D 104515106 deoxyribodipyrimidine photo-lyase-like K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]
C BER (base exicision repair)
D DNA glycosylases
E 104514784 UNG; uracil-DNA glycosylase K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E 104515072 MUTYH; A/G-specific adenine DNA glycosylase K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
E 104506641 NTHL1; endonuclease III-like protein 1 K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
D RecJ
D DNA ligase
D DNA polymerase I
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase complex (RNAP)
E TRCF (transcription-repair coupling factor)
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
D Molecular matchmaker
D Strand discrimination factor
D DNA exonucleases
D DNA polymerase III holoenzyme
D DNA ligase
D Other MMR factors
E 104504437 SSBP1; single-stranded DNA-binding protein, mitochondrial K03111 ssb; single-strand DNA-binding protein
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D RecBC pathway proteins
D RecFOR pathway proteins
D AddAB pathway proteins
D Other HR factor
D Archaeal homologous recombinant proteins
C NHEJ (non-homologous end-joining)
D Two-component NHEJ DNA repair complex
D SHIIR (short-homology-independent illegitimate recombination)
E Facilitator
E Supressor
D SHDIR (short-homology-dependent illegitimate recombination)
E RecET pathway
E Facilitator
E Supressor
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
C Other SOS response factors
D 104504437 SSBP1; single-stranded DNA-binding protein, mitochondrial K03111 ssb; single-strand DNA-binding protein
B Other factors with a suspected DNA repair function
C DNA polymerase
C DNA helicases
C Modulation of nucleotide pools
D 104517300 DUT; deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
C Others
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: March 29, 2024