+F Repair protein KO
#
DNA Repair and Recombination Proteins - Escherichia coli O44:H18 042 (EAEC)
%
!
AEukaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D EC042_1452 ogt; methylated-DNA--protein-cysteine methyltransferase K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
D EC042_0725 phrB; deoxyribodipyrimidine photolyase K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]
C BER (base exicision repair)
D DNA glycosylases
E EC042_2786 ung; uracil-DNA glycosylase K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E EC042_3168 mutY; A/G-specific adenine glycosylase K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
E EC042_1802 nth; endonuclease III K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
D Long Patch-BER factors
E DNA polymerase delta complex
E DNA polymerase epsilon complex
D Short Patch-BER factors
D Other BER factors
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E XPC-HR23B-CETN2 complex
E Cul4-DDB2 complex
E NER4 complex
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase II complex
E Cul4-CSA complex
E Other TCR factor
D TFIIH complex
D RPA (replication factor A)
D Other NER factors
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
D MutL homologs
D DNA polymerase delta complex
D RPA (replication factor A)
D RFC (replication factor C)
D Other MMR factors
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D MRN(MRX) complex
D BRCA1-core complex
D BRCA1-A complex
D BRCA1-B complex
D BRCA1-C complex
D BRCA complex
D RecA family proteins
D Rad52 family proteins
D Rad54 family proteins
D RecQ family DNA helicases
D Bloom's syndrome complex (BTR)
D RPA (replication factor A)
D Protein phosphatase 4
D AP-5 complex
D SMC5-SMC6 complex
D Other HR factors
C NHEJ (non-homologous end-joining)
D DNA-PK complex
D MRX complex
D DNA Ligase 4 complex
D X-family DNA polymerases
D Other NHEJ factors
C FA (Fanconi anemia) pathway
D FA core complex
D FA core complex binding factors
D Bloom's syndrome complex (BTR)
D FANCD2-I complex
D Downstream FA components
D Other FA pathway factors
C Other DSBR factors
D Protein phosphatase 6
D Ubiquitin ligases
D Others
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
C B-family DNA polymerases
C A-family DNA polymerase
C Rad6 epistasis group
C Other TLS factors
B Check point factors
C Rad9-Hus1-Rad1 complex
C HRAD17(Rad24)-RFC complex
C Rad17-Mec3-Ddc1 complex
C FPC (fork protection complex)
C Triple T complex
C BAG6-UBL4A-GET4 complex
C Other check point factors
B Other factors with a suspected DNA repair function
C DNA polymerases
C Nucleases
C Helicases
C PSO4 complex
C Modulation of nucleotide pools
D EC042_0100 mutT; mutator protein (7,8-dihydro-8-oxoguanine-triphosphatase) K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D EC042_3946 dut; deoxyuridine 5'-triphosphate nucleotidohydrolase K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
#
AProkaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D EC042_1452 ogt; methylated-DNA--protein-cysteine methyltransferase K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
D EC042_2454 ada; regulatory protein of adaptative response [contains: methylated-DNA--protein-cysteine methyltransferase] K10778 ada; AraC family transcriptional regulator, regulatory protein of adaptative response / methylated-DNA-[protein]-cysteine methyltransferase [EC:2.1.1.63]
D EC042_0725 phrB; deoxyribodipyrimidine photolyase K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]
D EC042_2453 alkB; alpha-ketoglutarate-dependent dioxygenase (alkylated DNA repair protein) K03919 alkB; DNA oxidative demethylase [EC:1.14.11.33]
C BER (base exicision repair)
D DNA glycosylases
E EC042_2786 ung; uracil-DNA glycosylase K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E EC042_3362 mug; G/U mismatch-specific DNA glycosylase K03649 mug; double-stranded uracil-DNA glycosylase [EC:3.2.2.28]
E EC042_2307 alkA; DNA-3-methyladenine glycosidase II K01247 alkA; DNA-3-methyladenine glycosylase II [EC:3.2.2.21]
E EC042_3168 mutY; A/G-specific adenine glycosylase K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
E EC042_3855 tag; DNA-3-methyladenine glycosylase 1 K01246 tag; DNA-3-methyladenine glycosylase I [EC:3.2.2.20]
E EC042_3942 mutM; formamidopyrimidine-DNA glycosylase K10563 mutM; formamidopyrimidine-DNA glycosylase [EC:3.2.2.23 4.2.99.18]
E EC042_0731 nei; endonuclease VIII (DNA glycosylase/AP lyase Nei) K05522 nei; endonuclease VIII [EC:3.2.2.- 4.2.99.18]
E EC042_1802 nth; endonuclease III K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
E EC042_1914 xthA; exodeoxyribonuclease III K01142 E3.1.11.2; exodeoxyribonuclease III [EC:3.1.11.2]
E EC042_2392 nfo; Probable endonuclease IV K01151 nfo; deoxyribonuclease IV [EC:3.1.21.2]
E EC042_4365 nfi; endonuclease V K05982 E3.1.21.7; deoxyribonuclease V [EC:3.1.21.7]
D RecJ
E EC042_3103 recJ; single-stranded DNA-specific exonuclease K07462 recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-]
D DNA ligase
E EC042_3979 putative DNA ligase K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
E EC042_2620 ligA; DNA ligase K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
D DNA polymerase I
E EC042_4237 polA; DNA polymerase I K02335 polA; DNA polymerase I [EC:2.7.7.7]
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E EC042_4427 uvrA; UvrABC system protein A (excinuclease ABC subunit A) K03701 uvrA; excinuclease ABC subunit A
E EC042_0862 uvrB; UvrABC system protein B (excinuclease ABC subunit B) K03702 uvrB; excinuclease ABC subunit B
E EC042_2074 uvrC; UvrABC system protein C K03703 uvrC; excinuclease ABC subunit C
E EC042_1906 cho; excinuclease Cho K05984 cho; excinuclease Cho [EC:3.1.25.-]
E EC042_4193 uvrD; DNA helicase II K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E EC042_4237 polA; DNA polymerase I K02335 polA; DNA polymerase I [EC:2.7.7.7]
E EC042_3979 putative DNA ligase K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
E EC042_2620 ligA; DNA ligase K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase complex (RNAP)
F EC042_4354 rpoB; DNA-directed RNA polymerase, beta-subunit K03043 rpoB; DNA-directed RNA polymerase subunit beta [EC:2.7.7.6]
F EC042_4355 rpoC; DNA-directed RNA polymerase, beta'-subunit K03046 rpoC; DNA-directed RNA polymerase subunit beta' [EC:2.7.7.6]
F EC042_3571 rpoA; DNA-directed RNA polymerase alpha chain K03040 rpoA; DNA-directed RNA polymerase subunit alpha [EC:2.7.7.6]
F EC042_3982 rpoZ; DNA-directed RNA polymerase omega chain K03060 rpoZ; DNA-directed RNA polymerase subunit omega [EC:2.7.7.6]
E TRCF (transcription-repair coupling factor)
F EC042_1184 mfd; transcription-repair coupling factor K03723 mfd; transcription-repair coupling factor (superfamily II helicase) [EC:5.6.2.4]
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
E EC042_2928 mutS; DNA mismatch repair protein K03555 mutS; DNA mismatch repair protein MutS
D Molecular matchmaker
E EC042_4643 mutL; DNA mismatch repair protein K03572 mutL; DNA mismatch repair protein MutL
D Strand discrimination factor
E EC042_3029 mutH; DNA mismatch repair protein K03573 mutH; DNA mismatch repair protein MutH
D DNA exonucleases
E EC042_2256 sbcB; exodeoxyribonuclease I K01141 sbcB; exodeoxyribonuclease I [EC:3.1.11.1]
E EC042_2710 xseA; exodeoxyribonuclease 7 large subunit K03601 xseA; exodeoxyribonuclease VII large subunit [EC:3.1.11.6]
E EC042_0460 xseB; exodeoxyribonuclease 7 small subunit K03602 xseB; exodeoxyribonuclease VII small subunit [EC:3.1.11.6]
E EC042_2009 exoX; exodeoxyribonuclease X K10857 exoX; exodeoxyribonuclease X [EC:3.1.11.-]
D DNA polymerase III holoenzyme
E EC042_0182 dnaE; DNA polymerase III alpha subunit K02337 dnaE; DNA polymerase III subunit alpha [EC:2.7.7.7]
E EC042_4057 dnaN; DNA polymerase III beta-subunit K02338 dnaN; DNA polymerase III subunit beta [EC:2.7.7.7]
E EC042_4734 holC; DNA polymerase III, chi subunit K02339 holC; DNA polymerase III subunit chi [EC:2.7.7.7]
E EC042_0675 holA; DNA polymerase III, delta subunit K02340 holA; DNA polymerase III subunit delta [EC:2.7.7.7]
E EC042_1169 holB; DNA polymerase III, delta' subunit K02341 holB; DNA polymerase III subunit delta' [EC:2.7.7.7]
E EC042_0208 dnaQ; DNA polymerase III epsilon subunit K02342 dnaQ; DNA polymerase III subunit epsilon [EC:2.7.7.7]
E EC042_0508 dnaX; DNA polymerase III subunits gamma and tau K02343 dnaX; DNA polymerase III subunit gamma/tau [EC:2.7.7.7]
E EC042_4868 holD; DNA polymerase III, psi subunit K02344 holD; DNA polymerase III subunit psi [EC:2.7.7.7]
E EC042_2007 DNA polymerase III, theta subunit K02345 holE; DNA polymerase III subunit theta [EC:2.7.7.7]
D DNA ligase
E EC042_3979 putative DNA ligase K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
E EC042_2620 ligA; DNA ligase K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
D Other MMR factors
E EC042_4193 uvrD; DNA helicase II K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E EC042_pAA113 ssb; single-stranded DNA-binding protein K03111 ssb; single-strand DNA-binding protein
E EC042_4428 ssb; single-stranded binding protein K03111 ssb; single-strand DNA-binding protein
E EC042_2428 putative single-strand DNA binding prophage protein K03111 ssb; single-strand DNA-binding protein
E EC042_2161 putative prophage single-stranded DNA binding protein K03111 ssb; single-strand DNA-binding protein
E EC042_3648 dam; DNA adenine methylase K06223 dam; DNA adenine methylase [EC:2.1.1.72]
E EC042_2117 vsr; patch repair protein K07458 vsr; DNA mismatch endonuclease, patch repair protein [EC:3.1.-.-]
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D RecBC pathway proteins
E EC042_3016 recB; exodeoxyribonuclease V beta subunit K03582 recB; exodeoxyribonuclease V beta subunit [EC:3.1.11.5]
E EC042_3018 recC; exodeoxyribonuclease V gamma subunit K03583 recC; exodeoxyribonuclease V gamma subunit [EC:3.1.11.5]
E EC042_3015 recD; exodeoxyribonuclease V alpha subunit K03581 recD; exodeoxyribonuclease V alpha subunit [EC:3.1.11.5]
E EC042_2892 recA; RecA protein (recombinase A) K03553 recA; recombination protein RecA
E EC042_2028 ruvA; holliday junction ATP-dependent DNA helicase K03550 ruvA; holliday junction DNA helicase RuvA
E EC042_2027 ruvB; holliday junction ATP-dependent DNA helicase K03551 ruvB; holliday junction DNA helicase RuvB [EC:5.6.2.4]
E EC042_2030 ruvC; crossover junction endodeoxyribonuclease K01159 ruvC; crossover junction endodeoxyribonuclease RuvC [EC:3.1.21.10]
E EC042_1343 putative phage endodeoxyribonuclease K01160 rusA; crossover junction endodeoxyribonuclease RusA [EC:3.1.21.10]
E EC042_0819 prophage holliday junction resolvase K01160 rusA; crossover junction endodeoxyribonuclease RusA [EC:3.1.21.10]
E EC042_2182 putative prophage endonuclease K01160 rusA; crossover junction endodeoxyribonuclease RusA [EC:3.1.21.10]
E EC042_4309 priA; primosomal protein replication factor K04066 priA; primosomal protein N' (replication factor Y) (superfamily II helicase) [EC:5.6.2.4]
E EC042_4682A priB; primosomal replication protein N K02686 priB; primosomal replication protein N
E EC042_0505 priC; primosomal replication protein N K04067 priC; primosomal replication protein N''
E EC042_4859 dnaT; primosomal protein I K02317 dnaT; DNA replication protein DnaT
E EC042_2256 sbcB; exodeoxyribonuclease I K01141 sbcB; exodeoxyribonuclease I [EC:3.1.11.1]
E EC042_0429 sbcC; exonuclease SbcC K03546 sbcC; DNA repair protein SbcC/Rad50
E EC042_0430 sbcD; exonuclease SbcD K03547 sbcD; DNA repair protein SbcD/Mre11
D RecFOR pathway proteins
E EC042_2892 recA; RecA protein (recombinase A) K03553 recA; recombination protein RecA
E EC042_4886 radA; DNA repair protein K04485 radA; DNA repair protein RadA/Sms
E EC042_4056 recF; DNA replication and repair protein K03629 recF; DNA replication and repair protein RecF
E EC042_3985 recG; ATP-dependent DNA helicase K03655 recG; ATP-dependent DNA helicase RecG [EC:5.6.2.4]
E EC042_3103 recJ; single-stranded DNA-specific exonuclease K07462 recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-]
E EC042_2769 recO; DNA repair protein K03584 recO; DNA repair protein RecO (recombination protein O)
E EC042_0510 recR; recombination protein K06187 recR; recombination protein RecR
E EC042_2815 recN; DNA repair protein K03631 recN; DNA repair protein RecN (Recombination protein N)
E EC042_0426 rdgC; recombination associated protein K03554 rdgC; recombination associated protein RdgC
E EC042_2028 ruvA; holliday junction ATP-dependent DNA helicase K03550 ruvA; holliday junction DNA helicase RuvA
E EC042_2027 ruvB; holliday junction ATP-dependent DNA helicase K03551 ruvB; holliday junction DNA helicase RuvB [EC:5.6.2.4]
E EC042_2030 ruvC; crossover junction endodeoxyribonuclease K01159 ruvC; crossover junction endodeoxyribonuclease RuvC [EC:3.1.21.10]
D AddAB pathway proteins
D Other HR factor
E EC042_2950 CRISPR-associated protein K15342 cas1; CRISP-associated protein Cas1
E EC042_2417 putative helicase K19789 radD; DNA repair protein RadD
D Archaeal homologous recombinant proteins
E EC042_0429 sbcC; exonuclease SbcC K03546 sbcC; DNA repair protein SbcC/Rad50
E EC042_0430 sbcD; exonuclease SbcD K03547 sbcD; DNA repair protein SbcD/Mre11
E EC042_4738 conserved hypothetical protein K06915 herA; DNA double-strand break repair helicase HerA and related ATPase
C NHEJ (non-homologous end-joining)
D Two-component NHEJ DNA repair complex
D SHIIR (short-homology-independent illegitimate recombination)
E Facilitator
F EC042_2471 gyrA; DNA gyrase subunit A K02469 gyrA; DNA gyrase subunit A [EC:5.6.2.2]
F EC042_4055 gyrB; DNA gyrase subunit B K02470 gyrB; DNA gyrase subunit B [EC:5.6.2.2]
F EC042_1399 topA; DNA topoisomerase I (omega protein) K03168 topA; DNA topoisomerase I [EC:5.6.2.1]
E Supressor
F EC042_4367 hupA; DNA-binding protein HU-alpha K05787 hupA; DNA-binding protein HU-alpha
F EC042_0478 hupB; DNA-binding protein HU-beta K03530 hupB; DNA-binding protein HU-beta
D SHDIR (short-homology-dependent illegitimate recombination)
E RecET pathway
F EC042_1467 putative phage exodeoxyribonuclease K10906 recE; exodeoxyribonuclease VIII [EC:3.1.11.-]
F EC042_2203 putative exodeoxyribonuclease VIII K10906 recE; exodeoxyribonuclease VIII [EC:3.1.11.-]
F EC042_0801 phage recombination protein K07455 recT; recombination protein RecT
F EC042_3103 recJ; single-stranded DNA-specific exonuclease K07462 recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-]
F EC042_2769 recO; DNA repair protein K03584 recO; DNA repair protein RecO (recombination protein O)
F EC042_0510 recR; recombination protein K06187 recR; recombination protein RecR
F EC042_3979 putative DNA ligase K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
F EC042_2620 ligA; DNA ligase K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
E Facilitator
F EC042_3544 fis; DNA-binding protein K03557 fis; Fis family transcriptional regulator, factor for inversion stimulation protein
F EC042_1879 ihfA; Integration host factor alpha subunit K04764 ihfA; integration host factor subunit alpha
F EC042_1002 ihfB; integration host factor beta-subunit (IHF-beta) K05788 ihfB; integration host factor subunit beta
E Supressor
F EC042_2256 sbcB; exodeoxyribonuclease I K01141 sbcB; exodeoxyribonuclease I [EC:3.1.11.1]
F EC042_4202 recQ; ATP-dependent DNA helicase K03654 recQ; ATP-dependent DNA helicase RecQ [EC:5.6.2.4]
F EC042_4427 uvrA; UvrABC system protein A (excinuclease ABC subunit A) K03701 uvrA; excinuclease ABC subunit A
F EC042_0862 uvrB; UvrABC system protein B (excinuclease ABC subunit B) K03702 uvrB; excinuclease ABC subunit B
F EC042_1292 hns; DNA-binding protein (histone-like protein Hlp-II) K03746 hns; DNA-binding protein H-NS
F EC042_2834 putative histone-like DNA-binding protein K03746 hns; DNA-binding protein H-NS
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
D EC042_0289 dbh; DNA polymerase IV K02346 dinB; DNA polymerase IV [EC:2.7.7.7]
D EC042_1233 umuC; SOS mutagenesis and repair protein K03502 umuC; DNA polymerase V
D EC042_1232 umuD; SOS mutagenesis and repair protein K03503 umuD; DNA polymerase V [EC:3.4.21.-]
C Other SOS response factors
D EC042_2892 recA; RecA protein (recombinase A) K03553 recA; recombination protein RecA
D EC042_4412 lexA; LexA repressor K01356 lexA; repressor LexA [EC:3.4.21.88]
D EC042_2815 recN; DNA repair protein K03631 recN; DNA repair protein RecN (Recombination protein N)
D EC042_0063 polB; DNA polymerase II K02336 polB; DNA polymerase II [EC:2.7.7.7]
D EC042_pAA113 ssb; single-stranded DNA-binding protein K03111 ssb; single-strand DNA-binding protein
D EC042_4428 ssb; single-stranded binding protein K03111 ssb; single-strand DNA-binding protein
D EC042_2428 putative single-strand DNA binding prophage protein K03111 ssb; single-strand DNA-binding protein
D EC042_2161 putative prophage single-stranded DNA binding protein K03111 ssb; single-strand DNA-binding protein
D EC042_3977 dinD; dna-damage-inducible protein D K14623 dinD; DNA-damage-inducible protein D
D EC042_1128 dinI; damage-inducible protein K12149 dinI; DNA-damage-inducible protein I
D EC042_2891 recX; regulatory protein K03565 recX; regulatory protein
D EC042_3672 putative transposase K01157 rpnA; recombination-promoting nuclease RpnA [EC:3.1.21.-]
D EC042_2546 putative transposase K24087 rpnB; recombination-promoting nuclease RpnB [EC:3.1.21.-]
D EC042_0132 putative transposase K24088 rpnC; recombination-promoting nuclease RpnC [EC:3.1.21.-]
D EC042_2487 putative transposase K24090 rpnE; recombination-promoting nuclease RpnE
B Other factors with a suspected DNA repair function
C DNA polymerase
C DNA helicases
D EC042_4155 rep; ATP-dependent DNA helicase K03656 rep; ATP-dependent DNA helicase Rep [EC:5.6.2.4]
D EC042_1048 helD; helicase IV K03658 helD; DNA helicase IV [EC:5.6.2.4]
D EC042_1973 putative ATP-binding protein K03722 dinG; ATP-dependent DNA helicase DinG [EC:5.6.2.3]
D EC042_0889 dinG; probable ATP-dependent helicase K03722 dinG; ATP-dependent DNA helicase DinG [EC:5.6.2.3]
D EC042_3179 putative ATP-dependent helicase K03724 lhr; ATP-dependent helicase Lhr and Lhr-like helicase [EC:5.6.2.6 5.6.2.4]
D EC042_1822 lhr; probable ATP-dependent helicase K03724 lhr; ATP-dependent helicase Lhr and Lhr-like helicase [EC:5.6.2.6 5.6.2.4]
C Modulation of nucleotide pools
D EC042_0100 mutT; mutator protein (7,8-dihydro-8-oxoguanine-triphosphatase) K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D EC042_3946 dut; deoxyuridine 5'-triphosphate nucleotidohydrolase K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D EC042_2873 nrdE; ribonucleoside-diphosphate reductase 2 alpha chain K00525 E1.17.4.1A; ribonucleoside-diphosphate reductase alpha chain [EC:1.17.4.1]
D EC042_2474 nrdA; ribonucleoside-diphosphate reductase 1 alpha chain K00525 E1.17.4.1A; ribonucleoside-diphosphate reductase alpha chain [EC:1.17.4.1]
D EC042_2475 nrdB; ribonucleoside-diphosphate reductase 1 beta chain K00526 E1.17.4.1B; ribonucleoside-diphosphate reductase beta chain [EC:1.17.4.1]
D EC042_2874 nrdF; ribonucleoside-diphosphate reductase 2 beta chain K00526 E1.17.4.1B; ribonucleoside-diphosphate reductase beta chain [EC:1.17.4.1]
C Others
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#
#[ BRITE | KEGG2 | KEGG ]
#Last updated: March 29, 2024