+C Two-component system KO
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Two-Component System - Escherichia coli P12b
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AOmpR family
B PhoR-PhoB (phosphate starvation response)
C P12B_c0412 phoR; Signal transduction histidine kinase K07636 phoR; two-component system, OmpR family, phosphate regulon sensor histidine kinase PhoR [EC:2.7.13.3]
C P12B_c0411 phoB; Positive response regulator for pho regulon K07657 phoB; two-component system, OmpR family, phosphate regulon response regulator PhoB
B SenX3-RegX3 (phosphate starvation response)
B PhoQ-PhoP (magnesium transport)
C P12B_c1977 phoQ; sensory histidine kinase in two-compoent regulatory system with PhoP K07637 phoQ; two-component system, OmpR family, sensor histidine kinase PhoQ [EC:2.7.13.3]
C P12B_c1976 phoP; Transcriptional regulatory protein phoP K07660 phoP; two-component system, OmpR family, response regulator PhoP
B EnvZ-OmpR (osmotic stress response)
C P12B_c3503 envZ; Osmolarity sensor protein envZ K07638 envZ; two-component system, OmpR family, osmolarity sensor histidine kinase EnvZ [EC:2.7.13.3]
C P12B_c3504 hypothetical protein K07659 ompR; two-component system, OmpR family, phosphate regulon response regulator OmpR
B RstB-RstA
C P12B_c1475 rstB; sensory histidine kinase in two-component regulatory system with RstA K07639 rstB; two-component system, OmpR family, sensor histidine kinase RstB [EC:2.7.13.3]
C P12B_c1476 rstA; Response transcriptional regulatory protein K07661 rstA; two-component system, OmpR family, response regulator RstA
B CpxA-CpxR (envelope stress response)
C P12B_c4028 cpxA; two-component sensor protein K07640 cpxA; two-component system, OmpR family, sensor histidine kinase CpxA [EC:2.7.13.3]
C P12B_c4029 cpxR; Transcriptional regulatory protein cpxR K07662 cpxR; two-component system, OmpR family, response regulator CpxR
B CssS-CssR (secretion stress response)
B CreC-CreB (phosphate regulation)
C P12B_c4474 creC; sensory histidine kinase in two-component regulatory system with CreB or PhoB, regulator of the CreBC regulon K07641 creC; two-component system, OmpR family, sensor histidine kinase CreC [EC:2.7.13.3]
C P12B_c4473 creB; Transcriptional regulatory protein creB K07663 creB; two-component system, OmpR family, catabolic regulation response regulator CreB
B BaeS-BaeR (envelope stress response)
C P12B_c2181 baeS; Signal transduction histidine-protein kinase baeS K07642 baeS; two-component system, OmpR family, sensor histidine kinase BaeS [EC:2.7.13.3]
C P12B_c2182 baeR; Transcriptional regulatory protein baeR K07664 baeR; two-component system, OmpR family, response regulator BaeR
B BasS-BasR (antimicrobial peptide resistance)
C P12B_c4215 basS; integral membrane sensor signal transduction histidine kinase K07643 basS; two-component system, OmpR family, sensor histidine kinase BasS [EC:2.7.13.3]
C P12B_c4216 basR; DNA-binding response regulator BasR K07771 basR; two-component system, OmpR family, response regulator BasR
B CusS-CusR (copper tolerance)
C P12B_c0553 cusS; Sensor kinase cusS K07644 cusS; two-component system, OmpR family, heavy metal sensor histidine kinase CusS [EC:2.7.13.3]
C P12B_c3593 hypothetical protein K07644 cusS; two-component system, OmpR family, heavy metal sensor histidine kinase CusS [EC:2.7.13.3]
C P12B_c3612 hypothetical protein K07644 cusS; two-component system, OmpR family, heavy metal sensor histidine kinase CusS [EC:2.7.13.3]
C P12B_c0554 ylcA; Transcriptional regulatory protein cusR K07665 cusR; two-component system, OmpR family, copper resistance phosphate regulon response regulator CusR
C P12B_c3594 pcoR; Transcriptional regulatory protein pcoR K07665 cusR; two-component system, OmpR family, copper resistance phosphate regulon response regulator CusR
C P12B_c3611 silR; DNA-binding response regulator in two-component regulatory system with CusS K07665 cusR; two-component system, OmpR family, copper resistance phosphate regulon response regulator CusR
B QseC-QseB (quorum sensing)
C P12B_c3126 qseC; sensory histidine kinase in two-component regulatory system with QseB K07645 qseC; two-component system, OmpR family, sensor histidine kinase QseC [EC:2.7.13.3]
C P12B_c3125 qseB; Two component transcriptional regulator, winged helix family precursor K07666 qseB; two-component system, OmpR family, response regulator QseB
B KdpD-KdpE (potassium transport)
C P12B_c0666 kdpD; fused sensory histidine kinase in two-component regulatory system with KdpE: signal sensing protein K07646 kdpD; two-component system, OmpR family, sensor histidine kinase KdpD [EC:2.7.13.3]
C P12B_c0665 kdpE; KDP operon transcriptional regulatory protein kdpE K07667 kdpE; two-component system, OmpR family, KDP operon response regulator KdpE
B TorS-TorR (TMAO respiration)
C P12B_c0980 torS; hybrid sensory histidine kinase in two-component regulatory system with TorR K07647 torS; two-component system, OmpR family, sensor histidine kinase TorS [EC:2.7.13.3]
C P12B_c0982 torR; TorCAD operon transcriptional regulatory protein torR K07772 torR; two-component system, OmpR family, torCAD operon response regulator TorR
B ArcB-ArcA (anoxic redox control)
C P12B_c4476 arcA; Aerobic respiration control protein arcA K07773 arcA; two-component system, OmpR family, aerobic respiration control protein ArcA
B TctE-TctD (tricarboxylic acid transport)
B ResE-ResD (aerobic and anaerobic respiration)
B VicK-VicR (cell wall metabolism)
B MprB-MprA (maintenance of persistent infection)
B MtrB-MtrA (osmotic stress response)
B PrrB-PrrA (intracellular multiplication)
B TrcS-TrcR
B NrsS-NrsR (nickel tolerance)
B ManS-ManR (manganese homeostasis)
B NblS-NblR (photosynthesis)
B SasA-RpaAB (circadian timing mediating)
B SaeS-SaeR (staphylococcal virulence regulation)
B BceS-BceR (bacitracin transport)
B BraS-BraR (bacitracin transport)
B GraS-GraR (cationic antimicrobial peptide transport)
B YxdK-YxdJ (antimicrobial peptide response)
B ChvG-ChvI (acidity sensing)
B CiaH-CiaR
B ParS-ParR (polymyxin-adaptive resistance)
B AdeS-AdeR
B VanS-VanR (VanB type vancomycin resistance)
B VanS-VanR (VanE type vancomycin resistance)
B VanS-VanR (actinomycete type vancomycin resistance)
B ArlS-ArlR (virulence regulation)
B Ihk-Irr (virulence regulation)
B PfeS-PfeR (enterobactin-dependent iron acquisition)
B NisK-NisR (lantibiotic biosynthesis)
B Unclassified
C P12B_c1055 yedV; Putative sensor-like histidine kinase yedV K02484 K02484; two-component system, OmpR family, sensor kinase [EC:2.7.13.3]
C P12B_c1054 Heavy metal response regulator K02483 K02483; two-component system, OmpR family, response regulator
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ANarL family
B NarX-NarL (nitrate respiration)
C P12B_c1913 narX; Nitrate/nitrite sensor protein NarX K07673 narX; two-component system, NarL family, nitrate/nitrite sensor histidine kinase NarX [EC:2.7.13.3]
C P12B_c1914 narL; Nitrate/nitrite response regulator protein narL K07684 narL; two-component system, NarL family, nitrate/nitrite response regulator NarL
B NarQ-NarP (nitrate respiration)
C P12B_c2571 narQ; Signal transduction histidine kinase, nitrate/nitrite-specific K07674 narQ; two-component system, NarL family, nitrate/nitrite sensor histidine kinase NarQ [EC:2.7.13.3]
C P12B_c2284 narP; Nitrate/nitrite response regulator NarP K07685 narP; two-component system, NarL family, nitrate/nitrite response regulator NarP
B UhpB-UhpA (hexose phosphates uptake)
C P12B_c3807 uhpB; sensory histidine kinase UhpB K07675 uhpB; two-component system, NarL family, sensor histidine kinase UhpB [EC:2.7.13.3]
C P12B_c3808 uhpA; Response regulator (Repressor) in two-component regulatory system wtih UhpB, regulates uhpT operon K07686 uhpA; two-component system, NarL family, uhpT operon response regulator UhpA
B FusK-FusR (virulence regulation)
B RcsC-RcsD-RcsB (capsule synthesis)
C P12B_c2310 rcsC; sensor histidine kinase/response regulator RcsC K07677 rcsC; two-component system, NarL family, capsular synthesis sensor histidine kinase RcsC [EC:2.7.13.3]
C P12B_c2307 rcsD; Hpt sensor signal transduction histidine kinase precursor K07676 rcsD; two-component system, NarL family, sensor histidine kinase RcsD [EC:2.7.13.3]
C P12B_c2308 rcsB; Capsular synthesis regulator component B K07687 rcsB; two-component system, NarL family, captular synthesis response regulator RcsB
B BarA-UvrY (central carbon metabolism)
C P12B_c2884 barA; Signal transduction histidine-protein kinase barA K07678 barA; two-component system, NarL family, sensor histidine kinase BarA [EC:2.7.13.3]
C P12B_c1150 uvrY; Response regulator uvrY K07689 uvrY; two-component system, NarL family, invasion response regulator UvrY
B ComP-ComA (competence)
B EvgS-EvgA (acid and drug tolerance)
C P12B_c2487 evgS; hybrid sensory histidine kinase in two-component regulatory system with EvgA K07679 evgS; two-component system, NarL family, sensor histidine kinase EvgS [EC:2.7.13.3]
C P12B_c2486 evgA; Positive transcription regulator evgA K07690 evgA; two-component system, NarL family, response regulator EvgA
C P12B_c0547 fimZ; Fimbrial Z protein K07688 fimZ; two-component system, NarL family, response regulator, fimbrial Z protein, FimZ
B DegS-DegU (multicellular behavior control)
B DesK-DesR (membrane lipid fluidity regulation)
B VraS-VraR (cell-wall peptidoglycan synthesis)
B LiaS-LiaR (cell wall stress response)
B DevS-DevR (redox response)
B NreB-NreC (dissimilatory nitrate/nitrite reduction)
B YdfH-YdfI
B SalK-SalR
B PprA–PprB (biofilm formation)
B Unclassified
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ASpo family
B KinABCDE-Spo0FA (sporulation control)
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ACitB family
B CitA-CitB (citrate fermentation)
C P12B_c0603 citA; Sensor kinase dpiB K07700 dpiB; two-component system, CitB family, cit operon sensor histidine kinase CitA [EC:2.7.13.3]
C P12B_c0604 dpiA; Transcriptional regulatory protein dpiA K07702 dpiA; two-component system, CitB family, response regulator CitB
B CitS-CitT (magnesium-citrate transport)
B DcuS-DcuR (C4-dicarboxylate metabolism)
C P12B_c4228 yjdH; sensory histidine kinase DcuS K07701 dcuS; two-component system, CitB family, sensor histidine kinase DcuS [EC:2.7.13.3]
C P12B_c4227 dcuR; Transcriptional regulatory protein dcuR K07703 dcuR; two-component system, CitB family, response regulator DcuR
B DctS-DctR (C4-dicarboxylate transport)
B MalK-MalR (malate transport)
B Unclassified
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ALytTR family
B LysS-LysR
B AlgZ-AlgR (alginate production)
B NatK-NatR (sodium extrusion)
B AgrC-AgrA (exoprotein synthesis)
B AgrC2-AgrA2 (virulence regulation)
B ComD-ComE (competence)
B Unclassified
C P12B_c2223 yehU; Putative regulator of cell autolysis K02478 K02478; two-component system, LytTR family, sensor kinase [EC:2.7.13.3]
C P12B_c2499 hypothetical protein K02478 K02478; two-component system, LytTR family, sensor kinase [EC:2.7.13.3]
C P12B_c2222 yehT; putative two-component response-regulatory protein YehT K02477 K02477; two-component system, LytTR family, response regulator
C P12B_c2500 hypothetical protein K02477 K02477; two-component system, LytTR family, response regulator
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ANtrC family
B GlnL-GlnG (nitrogen regulation)
C P12B_c3985 ntrC; Nitrogen regulation protein NR K07712 glnG; two-component system, NtrC family, nitrogen regulation response regulator GlnG
B NtrY-NtrX (nitrogen regulation)
B HydH-HydG (metal tolerance)
C P12B_c4115 zraS; Signal transduction histidine kinase K07709 zraS; two-component system, NtrC family, sensor histidine kinase HydH [EC:2.7.13.3]
C P12B_c4116 zraR; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains K07713 zraR; two-component system, NtrC family, response regulator HydG
B AtoS-AtoC (cPHB biosynthesis)
C P12B_c2312 atoC; Acetoacetate metabolism regulatory protein atoC K07714 atoC; two-component system, NtrC family, response regulator AtoC
B PilS-PilR (type 4 fimbriae synthesis)
B GlrK-GlrR (amino sugar metabolism)
C P12B_c2657 yfhK; putative 2-component sensor protein K07711 glrK; two-component system, NtrC family, sensor histidine kinase GlrK [EC:2.7.13.3]
C P12B_c2655 hypothetical protein K07715 glrR; two-component system, NtrC family, response regulator GlrR
B PgtB-PgtA (phosphoglycerate transport)
B DctB-DctD (C4-dicarboxylate transport)
B KinB-AlgB (alginate production)
B HupT-HupR (hydrogenase synthesis regulation)
B Unclassified
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ACheA family
B CheA-CheYBV (chemotaxis)
C P12B_c1197 cheA; Chemotaxis protein histidine kinase-like kinase K03407 cheA; two-component system, chemotaxis family, sensor kinase CheA [EC:2.7.13.3]
C P12B_c1203 cheY; Chemotaxis protein cheY K03413 cheY; two-component system, chemotaxis family, chemotaxis protein CheY
C P12B_c1202 cheB; Chemotaxis response regulator protein-glutamate methylesterase K03412 cheB; two-component system, chemotaxis family, protein-glutamate methylesterase/glutaminase [EC:3.1.1.61 3.5.1.44]
B ChpA-ChpB/PilGH (chemosensory)
B PixL-PixGH (positive phototaxis)
B WspE-WspRF (chemosensory)
B Cph1-Rcp1 (light response)
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ACell cycle family
B PleC-PleD (cell fate control)
B CckA-CtrA/CpdR (cell cycle control)
B Hk1-Rrp1 (glycerol uptake and utilization)
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ALux family
B LuxQN/CqsS-LuxU-LuxO (quorum sensing)
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ALuxR family
B DctS-DctR (C4-dicarboxylate transport)
B TtrS-TtrR (tetrathionate respiration)
B FixL-FixJ (nitrogen fixation)
B SsrA-SsrB
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AOther families
B FlrB-FlrC (polar flagellar synthesis)
C P12B_c0225 lafK; Sigma 54 K10943 flrC; two-component system, response regulator FlrC
B AauS-AauR (acidic amino acids utilization)
B SLN1-YPD1-SSK1/SKN7 (osmosensing)
B RpfC-RpfG (cell-to-cell signaling)
B GlnK-GlnL (glutamine utilization)
B HspS-HspR (hexose phosphates uptake)
B YesM-YesN
B CikA
B RegB-RegA (redox response)
B FitF-FitH (insecticidal toxin regulation)
B PhcS-PhcRQ
B SagS-HptB-HsbR (swarming activity and biofilm formation)
B PdtaS-PdtaR
B NasS-NasT
B Unclassified
C P12B_c1904 response regulator of RpoS K02485 rssB; two-component system, response regulator
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: December 14, 2023