+F Repair protein KO
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DNA Repair and Recombination Proteins - Eriocheir sinensis (Chinese mitten crab)
%
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AEukaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D 127001617 methylated-DNA--protein-cysteine methyltransferase-like K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
D 126992476 DNA oxidative demethylase ALKBH2-like K10859 ALKBH2; DNA oxidative demethylase [EC:1.14.11.33]
D 126995498 DNA oxidative demethylase ALKBH2-like K10859 ALKBH2; DNA oxidative demethylase [EC:1.14.11.33]
D 127010089 activating signal cointegrator 1 complex subunit 3-like K18663 ASCC3; activating signal cointegrator complex subunit 3 [EC:5.6.2.4]
D 126982009 deoxyribodipyrimidine photo-lyase-like K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]
C BER (base exicision repair)
D DNA glycosylases
E 126985615 cyclin-O-like K10861 UDG2; uracil-DNA glycosylase 2 [EC:3.2.2.-]
E 127004469 uncharacterized protein LOC127004469 K20813 TDG; thymine-DNA glycosylase [EC:3.2.2.29]
E 127010215 DNA-3-methyladenine glycosylase-like K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]
E 126985898 single-strand selective monofunctional uracil DNA glycosylase-like K10800 SMUG1; single-strand selective monofunctional uracil DNA glycosylase [EC:3.2.2.-]
E 127006552 adenine DNA glycosylase-like isoform X1 K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
E 126994209 N-glycosylase/DNA lyase-like K03660 OGG1; N-glycosylase/DNA lyase [EC:3.2.2.- 4.2.99.18]
E 126994912 endonuclease 8-like 1 K10567 NEIL1; endonuclease VIII-like 1 [EC:3.2.2.- 4.2.99.18]
E 127007952 endonuclease 8-like 3 isoform X1 K10569 NEIL3; endonuclease VIII-like 3 [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
E 127007113 DNA-(apurinic or apyrimidinic site) endonuclease-like K10771 APEX1; AP endonuclease 1 [EC:3.1.11.2]
E 126997502 DNA-(apurinic or apyrimidinic site) endonuclease 2-like isoform X1 K10772 APEX2; AP endonuclease 2 [EC:3.1.11.2]
D Long Patch-BER factors
E DNA polymerase delta complex
F 127008325 DNA polymerase delta catalytic subunit-like isoform X1 K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
F 126994853 DNA polymerase delta subunit 2-like K02328 POLD2; DNA polymerase delta subunit 2
E DNA polymerase epsilon complex
F 126983939 DNA polymerase epsilon catalytic subunit A-like K02324 POLE; DNA polymerase epsilon subunit 1 [EC:2.7.7.7]
F 126984352 DNA polymerase epsilon subunit 2-like K02325 POLE2; DNA polymerase epsilon subunit 2 [EC:2.7.7.7]
F 126998282 DNA polymerase epsilon subunit 4-like K03506 POLE4; DNA polymerase epsilon subunit 4 [EC:2.7.7.7]
E 127001216 proliferating cell nuclear antigen-like K04802 PCNA; proliferating cell nuclear antigen
E 126981877 flap endonuclease 1-like K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
E 126992367 flap endonuclease 1-like isoform X1 K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
E 127005425 DNA ligase 1-like isoform X1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
D Short Patch-BER factors
E 126995526 DNA polymerase beta-like K02330 POLB; DNA polymerase beta [EC:2.7.7.7 4.2.99.-]
E 127005189 DNA repair protein XRCC1-like K10803 XRCC1; DNA-repair protein XRCC1
E 127009957 DNA ligase 3-like K10776 LIG3; DNA ligase 3 [EC:6.5.1.1]
D Other BER factors
E 126992666 probable tyrosyl-DNA phosphodiesterase K10862 TDP1; tyrosyl-DNA phosphodiesterase 1 [EC:3.1.4.-]
E 126994306 aprataxin-like K10863 APTX; aprataxin [EC:3.6.1.70 3.6.1.71 3.6.1.72]
E 126983040 uncharacterized protein F21D5.5-like isoform X1 K08073 PNKP; bifunctional polynucleotide phosphatase/kinase [EC:3.1.3.32 2.7.1.78]
E 127007064 high mobility group protein DSP1-like K10802 HMGB1; high mobility group protein B1
E 127007266 high mobility group protein DSP1-like K10802 HMGB1; high mobility group protein B1
E 127007323 DNA polymerase lambda-like isoform X1 K03512 POLL; DNA polymerase lambda [EC:2.7.7.7 4.2.99.-]
E 126995746 poly [ADP-ribose] polymerase-like K24070 PARP1; poly [ADP-ribose] polymerase 1 [EC:2.4.2.30]
E 127007317 protein mono-ADP-ribosyltransferase PARP3-like K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
E 126981510 poly [ADP-ribose] polymerase 2-like isoform X1 K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E XPC-HR23B-CETN2 complex
F 126988806 UV excision repair protein RAD23 homolog B-like K10839 RAD23; UV excision repair protein RAD23
E Cul4-DDB2 complex
F 127007764 RING-box protein 1A K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
F 127006555 cullin-4A-like K10609 CUL4; cullin 4
F 126981367 DNA damage-binding protein 1-like K10610 DDB1; DNA damage-binding protein 1
E NER4 complex
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase II complex
F 127006180 DNA-directed RNA polymerase II subunit RPB1-like K03006 RPB1; DNA-directed RNA polymerase II subunit RPB1 [EC:2.7.7.6]
F 127006260 DNA-directed RNA polymerase II subunit RPB1-like K03006 RPB1; DNA-directed RNA polymerase II subunit RPB1 [EC:2.7.7.6]
F 127002566 DNA-directed RNA polymerase II subunit RPB1-like K03006 RPB1; DNA-directed RNA polymerase II subunit RPB1 [EC:2.7.7.6]
F 126996729 DNA-directed RNA polymerase II subunit RPB2 K03010 RPB2; DNA-directed RNA polymerase II subunit RPB2 [EC:2.7.7.6]
F 126990594 DNA-directed RNA polymerase II subunit RPB2-like isoform X1 K03010 RPB2; DNA-directed RNA polymerase II subunit RPB2 [EC:2.7.7.6]
F 127000849 DNA-directed RNA polymerase II subunit RPB3-like isoform X1 K03011 RPB3; DNA-directed RNA polymerase II subunit RPB3
F 127005962 DNA-directed RNA polymerases I, II, and III subunit RPABC1 K03013 RPABC1; DNA-directed RNA polymerases I, II, and III subunit RPABC1
F 126983996 DNA-directed RNA polymerases I, II, and III subunit RPABC2-like K03014 RPABC2; DNA-directed RNA polymerases I, II, and III subunit RPABC2
F 127008566 DNA-directed RNA polymerase II subunit RPB7 K03015 RPB7; DNA-directed RNA polymerase II subunit RPB7
F 127008152 DNA-directed RNA polymerases I, II, and III subunit RPABC3-like isoform X1 K03016 RPABC3; DNA-directed RNA polymerases I, II, and III subunit RPABC3
F 127009309 DNA-directed RNA polymerase II subunit RPB9-like K03017 RPB9; DNA-directed RNA polymerase II subunit RPB9
F 127009590 DNA-directed RNA polymerase II subunit RPB11-like K03008 RPB11; DNA-directed RNA polymerase II subunit RPB11
E Cul4-CSA complex
F 127007764 RING-box protein 1A K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
F 127006555 cullin-4A-like K10609 CUL4; cullin 4
F 126981367 DNA damage-binding protein 1-like K10610 DDB1; DNA damage-binding protein 1
F 127002886 DNA excision repair protein ERCC-8-like isoform X1 K10570 ERCC8; DNA excision repair protein ERCC-8
E Other TCR factor
F 127009501 DNA excision repair protein ERCC-6-like isoform X1 K10841 ERCC6; DNA excision repair protein ERCC-6
F 127009087 UV-stimulated scaffold protein A-like K23720 UVSSA; UV-stimulated scaffold protein A
F 126988188 transcription elongation factor 1 homolog K25829 ELOF1; transcription elongation factor 1
D TFIIH complex
E 126996611 general transcription and DNA repair factor IIH helicase subunit XPB-like K10843 ERCC3; DNA excision repair protein ERCC-3 [EC:5.6.2.4]
E 126982373 general transcription and DNA repair factor IIH helicase subunit XPD-like K10844 ERCC2; DNA excision repair protein ERCC-2 [EC:5.6.2.3]
E 126981108 general transcription factor IIH subunit 1-like isoform X1 K03141 TFIIH1; transcription initiation factor TFIIH subunit 1
E 127004083 general transcription factor IIH subunit 2-like K03142 TFIIH2; transcription initiation factor TFIIH subunit 2
E 126980828 general transcription factor IIH subunit 3-like K03143 TFIIH3; transcription initiation factor TFIIH subunit 3
E 126992534 general transcription factor IIH subunit 3-like K03143 TFIIH3; transcription initiation factor TFIIH subunit 3
E 127004385 general transcription factor IIH subunit 4-like K03144 TFIIH4; transcription initiation factor TFIIH subunit 4
E 127009646 cyclin-dependent kinase 7-like K02202 CDK7; cyclin-dependent kinase 7 [EC:2.7.11.22 2.7.11.23]
E 127002028 cyclin-H-like K06634 CCNH; cyclin H
E 127001692 CDK-activating kinase assembly factor MAT1-like K10842 MNAT1; CDK-activating kinase assembly factor MAT1
D RPA (replication factor A)
E 126997370 replication protein A 70 kDa DNA-binding subunit-like K07466 RFA1; replication factor A1
E 127006994 replication protein A 32 kDa subunit-like K10739 RFA2; replication factor A2
E 126982342 uncharacterized protein LOC126982342 K10740 RPA3; replication factor A3
D Other NER factors
E 126995520 DNA excision repair protein ERCC-1-like K10849 ERCC1; DNA excision repair protein ERCC-1
E 127006113 DNA repair endonuclease XPF-like isoform X1 K10848 ERCC4; DNA excision repair protein ERCC-4 [EC:3.1.-.-]
E 127005425 DNA ligase 1-like isoform X1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
E 127006949 MMS19 nucleotide excision repair protein homolog K15075 MET18; DNA repair/transcription protein MET18/MMS19
E 127001723 cullin-3-B-like K03869 CUL3; cullin 3
E 126986066 cullin-5-like isoform X1 K10612 CUL5; cullin 5
E 126991966 cullin-5-like isoform X1 K10612 CUL5; cullin 5
E 127007839 elongin-C K03872 ELOC; elongin-C
E 126995257 transcription elongation factor B polypeptide 3-like isoform X1 K15076 ELOA; elongin-A
E 126995654 protein lingerer-like isoform X1 K26545 UBAP2; ubiquitin-associated protein 2
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
E 126997085 DNA mismatch repair protein Msh2-like K08735 MSH2; DNA mismatch repair protein MSH2
E 126982841 LOW QUALITY PROTEIN: DNA mismatch repair protein Msh3-like K08736 MSH3; DNA mismatch repair protein MSH3
E 126996094 DNA mismatch repair protein Msh3-like isoform X1 K08736 MSH3; DNA mismatch repair protein MSH3
E 126981199 DNA mismatch repair protein Msh6-like isoform X1 K08737 MSH6; DNA mismatch repair protein MSH6
D MutL homologs
E 126988615 DNA mismatch repair protein Mlh1-like K08734 MLH1; DNA mismatch repair protein MLH1
D DNA polymerase delta complex
E 127008325 DNA polymerase delta catalytic subunit-like isoform X1 K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
E 126994853 DNA polymerase delta subunit 2-like K02328 POLD2; DNA polymerase delta subunit 2
D RPA (replication factor A)
E 126997370 replication protein A 70 kDa DNA-binding subunit-like K07466 RFA1; replication factor A1
E 127006994 replication protein A 32 kDa subunit-like K10739 RFA2; replication factor A2
E 126982342 uncharacterized protein LOC126982342 K10740 RPA3; replication factor A3
D RFC (replication factor C)
E 127007480 replication factor C subunit 1-like K10754 RFC1; replication factor C subunit 1
E 126997375 replication factor C subunit 2-like K10755 RFC2_4; replication factor C subunit 2/4
E 126997391 replication factor C subunit 2-like K10755 RFC2_4; replication factor C subunit 2/4
E 127006203 replication factor C subunit 4-like K10755 RFC2_4; replication factor C subunit 2/4
E 126998509 replication factor C subunit 3-like K10756 RFC3_5; replication factor C subunit 3/5
E 127001489 replication factor C subunit 5-like K10756 RFC3_5; replication factor C subunit 3/5
D Other MMR factors
E 127001216 proliferating cell nuclear antigen-like K04802 PCNA; proliferating cell nuclear antigen
E 127001638 exonuclease 1-like K10746 EXO1; exonuclease 1 [EC:3.1.-.-]
E 127007064 high mobility group protein DSP1-like K10802 HMGB1; high mobility group protein B1
E 127007266 high mobility group protein DSP1-like K10802 HMGB1; high mobility group protein B1
E 127005425 DNA ligase 1-like isoform X1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
E 126996305 WD repeat-containing protein 76-like K24755 WDR76; WD repeat-containing protein 76
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D MRN(MRX) complex
E 126988030 double-strand break repair protein MRE11-like K10865 MRE11; double-strand break repair protein MRE11
E 126984303 DNA repair protein RAD50-like isoform X1 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
D BRCA1-core complex
D BRCA1-A complex
E 127007819 BRISC and BRCA1-A complex member 1-like K20776 BABAM; BRISC and BRCA1-A complex member 1
E 126982679 BRISC and BRCA1-A complex member 2-like isoform X1 K12173 BRE; BRCA1-A complex subunit BRE
E 126985352 lys-63-specific deubiquitinase BRCC36-like isoform X1 K11864 BRCC3; BRCA1/BRCA2-containing complex subunit 3 [EC:3.4.19.-]
D BRCA1-B complex
E 126995948 DNA topoisomerase 2-binding protein 1-like isoform X1 K10728 TOPBP1; topoisomerase (DNA) II binding protein 1
D BRCA1-C complex
E 126988030 double-strand break repair protein MRE11-like K10865 MRE11; double-strand break repair protein MRE11
E 126984303 DNA repair protein RAD50-like isoform X1 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
D BRCA complex
E 127003703 DNA repair protein RAD51 homolog A-like isoform X1 K04482 RAD51; DNA repair protein RAD51
E 127004334 DNA repair protein RAD51 homolog A-like K04482 RAD51; DNA repair protein RAD51
D RecA family proteins
E 127003703 DNA repair protein RAD51 homolog A-like isoform X1 K04482 RAD51; DNA repair protein RAD51
E 127004334 DNA repair protein RAD51 homolog A-like K04482 RAD51; DNA repair protein RAD51
E 127009169 DNA repair protein RAD51 homolog 3-like K10870 RAD51L2; RAD51-like protein 2
E 126995211 DNA repair protein RAD51 homolog 4-like isoform X1 K10871 RAD51L3; RAD51-like protein 3
E 126999389 DNA repair protein XRCC2-like K10879 XRCC2; DNA-repair protein XRCC2
E 126998190 DNA repair protein XRCC3-like K10880 XRCC3; DNA-repair protein XRCC3
D Rad52 family proteins
E 126981486 RAD52 motif-containing protein 1-like isoform X1 K10874 RDM1; RAD52 motif-containing protein 1
D Rad54 family proteins
E 126987578 DNA repair and recombination protein RAD54-like K10875 RAD54L; DNA repair and recombination protein RAD54 and RAD54-like protein [EC:5.6.2.-]
E 127002044 DNA repair and recombination protein RAD54B-like K10877 RAD54B; DNA repair and recombination protein RAD54B [EC:5.6.2.-]
D RecQ family DNA helicases
E 126995608 ATP-dependent DNA helicase Q1-like K10899 RECQL; ATP-dependent DNA helicase Q1 [EC:5.6.2.4]
D Bloom's syndrome complex (BTR)
E 126996889 DNA topoisomerase 3-beta-1-like isoform X1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 126998305 DNA topoisomerase 3-alpha-like K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
D RPA (replication factor A)
E 126997370 replication protein A 70 kDa DNA-binding subunit-like K07466 RFA1; replication factor A1
E 127006994 replication protein A 32 kDa subunit-like K10739 RFA2; replication factor A2
E 126982342 uncharacterized protein LOC126982342 K10740 RPA3; replication factor A3
D Protein phosphatase 4
E 126981207 serine/threonine-protein phosphatase 4 catalytic subunit K15423 PPP4C; serine/threonine-protein phosphatase 4 catalytic subunit [EC:3.1.3.16]
E 126991225 serine/threonine-protein phosphatase 4 regulatory subunit 3A-like isoform X1 K17491 SMEK; protein phosphatase 4 regulatory subunit 3
E 126996987 serine/threonine-protein phosphatase 4 regulatory subunit 4-like K15426 PPP4R4; serine/threonine-protein phosphatase 4 regulatory subunit 4
D AP-5 complex
D SMC5-SMC6 complex
E 127006329 structural maintenance of chromosomes protein 5-like K22803 SMC5; structural maintenance of chromosomes protein 5
E 127008877 structural maintenance of chromosomes protein 6-like isoform X1 K22804 SMC6; structural maintenance of chromosomes protein 6
E 126984072 non-structural maintenance of chromosomes element 3 homolog K22823 NSMCE3; non-structural maintenance of chromosomes element 3
E 126980493 EP300-interacting inhibitor of differentiation 3-like K22825 NSMCE4; non-structural maintenance of chromosomes element 4
D Other HR factors
E 126997859 exonuclease 3'-5' domain-containing protein 2-like isoform X1 K20777 EXD2; exonuclease 3'-5' domain-containing protein 2 [EC:3.1.11.1]
E 127006980 exonuclease 3'-5' domain-containing protein 2-like isoform X1 K20777 EXD2; exonuclease 3'-5' domain-containing protein 2 [EC:3.1.11.1]
E 126988719 structure-specific endonuclease subunit slx1-like K15078 SLX1; structure-specific endonuclease subunit SLX1 [EC:3.6.1.-]
E 126985928 mortality factor 4-like protein 1 isoform X1 K11339 MORF4L1; mortality factor 4-like protein 1
E 126987670 deoxynucleoside triphosphate triphosphohydrolase SAMHD1-like K22544 SAMHD1; deoxynucleoside triphosphate triphosphohydrolase SAMHD1 [EC:3.1.5.-]
E 126980193 fidgetin-like protein 1 isoform X1 K22766 FIGNL1; fidgetin-like protein 1 [EC:5.6.2.-]
E 126980406 zinc finger SWIM domain-containing protein 7-like K25770 ZSWIM7; zinc finger SWIM domain-containing protein 7
E 127008185 protein MMS22-like K26125 MMS22L; protein MMS22-like
E 127002386 biorientation of chromosomes in cell division protein 1-like 1 isoform X1 K27262 BOD1L1; biorientation of chromosomes in cell division protein 1-like 1
C NHEJ (non-homologous end-joining)
D DNA-PK complex
E 127000900 X-ray repair cross-complementing protein 6-like K10884 XRCC6; ATP-dependent DNA helicase 2 subunit 1
E 127003880 X-ray repair cross-complementing protein 5-like K10885 XRCC5; ATP-dependent DNA helicase 2 subunit 2
E 127003883 X-ray repair cross-complementing protein 5-like K10885 XRCC5; ATP-dependent DNA helicase 2 subunit 2
E 126983497 DNA-dependent protein kinase catalytic subunit-like isoform X1 K06642 PRKDC; DNA-dependent protein kinase catalytic subunit [EC:2.7.11.1]
D MRX complex
E 126988030 double-strand break repair protein MRE11-like K10865 MRE11; double-strand break repair protein MRE11
E 126984303 DNA repair protein RAD50-like isoform X1 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
D DNA Ligase 4 complex
E 127001641 DNA ligase 4-like isoform X1 K10777 LIG4; DNA ligase 4 [EC:6.5.1.1]
D X-family DNA polymerases
E 127007323 DNA polymerase lambda-like isoform X1 K03512 POLL; DNA polymerase lambda [EC:2.7.7.7 4.2.99.-]
E 126995526 DNA polymerase beta-like K02330 POLB; DNA polymerase beta [EC:2.7.7.7 4.2.99.-]
D Other NHEJ factors
E 126994306 aprataxin-like K10863 APTX; aprataxin [EC:3.6.1.70 3.6.1.71 3.6.1.72]
E 127010128 protein artemis-like K10887 DCLRE1C; DNA cross-link repair 1C protein [EC:3.1.-.-]
E 126997642 tyrosyl-DNA phosphodiesterase 2-like K19619 TDP2; tyrosyl-DNA phosphodiesterase 2 [EC:3.1.4.-]
E 127005933 jmjC domain-containing protein 8-like isoform X1 K25792 JMJD8; jumonji domain-containing protein 8
C FA (Fanconi anemia) pathway
D FA core complex
E 126986420 E3 ubiquitin-protein ligase FANCL-like isoform X1 K10606 FANCL; E3 ubiquitin-protein ligase FANCL [EC:2.3.2.27]
E 127008240 Fanconi anemia core complex-associated protein 24-like isoform X1 K10898 FAAP24; fanconi anemia-associated protein
D FA core complex binding factors
E 126996690 transcription factor HES-4-B-like K06054 HES1; hairy and enhancer of split 1
E 126981263 centromere protein X-like K15360 STRA13; centromere protein X
E 127005870 ubiquitin-conjugating enzyme E2 T-like K13960 UBE2T; ubiquitin-conjugating enzyme E2 T [EC:2.3.2.23]
D Bloom's syndrome complex (BTR)
E 126996889 DNA topoisomerase 3-beta-1-like isoform X1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 126998305 DNA topoisomerase 3-alpha-like K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
D FANCD2-I complex
E 126981469 Fanconi anemia group D2 protein-like isoform X1 K10891 FANCD2; fanconi anemia group D2 protein
E 127008355 Fanconi anemia group I protein-like K10895 FANCI; fanconi anemia group I protein
D Downstream FA components
D Other FA pathway factors
E 127003703 DNA repair protein RAD51 homolog A-like isoform X1 K04482 RAD51; DNA repair protein RAD51
E 127004334 DNA repair protein RAD51 homolog A-like K04482 RAD51; DNA repair protein RAD51
E 127009169 DNA repair protein RAD51 homolog 3-like K10870 RAD51L2; RAD51-like protein 2
E 126999306 WD repeat-containing protein 48-like isoform X1 K15361 WDR48; WD repeat-containing protein 48
C Other DSBR factors
D Protein phosphatase 6
E 127008572 serine/threonine-protein phosphatase 6 catalytic subunit-like K15498 PPP6C; serine/threonine-protein phosphatase 6 catalytic subunit [EC:3.1.3.16]
E 127002166 serine/threonine-protein phosphatase 6 regulatory subunit 3-like isoform X1 K15501 PPP6R3; serine/threonine-protein phosphatase 6 regulatory subunit 3
D Ubiquitin ligases
E 126999844 E3 ubiquitin-protein ligase RNF8-like isoform X1 K10667 RNF8; E3 ubiquitin-protein ligase RNF8 [EC:2.3.2.27]
E 126981224 E3 ubiquitin-protein ligase rnf168-like isoform X1 K20779 RNF168; E3 ubiquitin-protein ligase RNF168 [EC:2.3.2.31]
E 127001164 E3 ubiquitin-protein ligase HERC2-like isoform X1 K10595 HERC2; E3 ubiquitin-protein ligase HERC2 [EC:2.3.2.26]
D Others
E 126998095 telomerase Cajal body protein 1-like isoform X1 K23314 WRAP53; telomerase Cajal body protein 1
E 127009716 WD repeat-containing protein 70-like K24752 WDR70; WD repeat-containing protein 70
E 126996305 WD repeat-containing protein 76-like K24755 WDR76; WD repeat-containing protein 76
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
D 126984386 DNA polymerase eta-like K03509 POLH; DNA polymerase eta [EC:2.7.7.7]
D 126998778 DNA polymerase kappa-like K03511 POLK; DNA polymerase kappa [EC:2.7.7.7]
C B-family DNA polymerases
C A-family DNA polymerase
C Rad6 epistasis group
D 127007376 ubiquitin-conjugating enzyme E2 A K10573 UBE2A; ubiquitin-conjugating enzyme E2 A [EC:2.3.2.23]
D 126987241 ubiquitin-conjugating enzyme E2 variant 2-like isoform X1 K10704 UBE2V; ubiquitin-conjugating enzyme E2 variant
D 127002849 ubiquitin-conjugating enzyme E2 N K10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23]
C Other TLS factors
D 127001216 proliferating cell nuclear antigen-like K04802 PCNA; proliferating cell nuclear antigen
D 126980929 DNA-dependent metalloprotease SPRTN-like K24051 SPRTN; SprT-like domain-contaning protein Spartan
D 127008285 DNA-dependent metalloprotease SPRTN-like isoform X1 K24051 SPRTN; SprT-like domain-contaning protein Spartan
D 126998430 uncharacterized protein LOC126998430 isoform X1 K26957 GCNA; germ cell nuclear acidic protein
B Check point factors
C Rad9-Hus1-Rad1 complex
D 126988917 cell cycle checkpoint control protein RAD9A-like K10994 RAD9A; cell cycle checkpoint control protein RAD9A [EC:3.1.11.2]
D 127002332 cell cycle checkpoint control protein RAD9A-like K10994 RAD9A; cell cycle checkpoint control protein RAD9A [EC:3.1.11.2]
D 127005670 checkpoint protein HUS1-like K10903 HUS1; HUS1 checkpoint protein
D 126996727 cell cycle checkpoint protein RAD1-like K02830 HRAD1; cell cycle checkpoint protein [EC:3.1.11.2]
C HRAD17(Rad24)-RFC complex
D 127002064 cell cycle checkpoint protein RAD17-like K06662 HRAD17; cell cycle checkpoint protein
D 126997375 replication factor C subunit 2-like K10755 RFC2_4; replication factor C subunit 2/4
D 126997391 replication factor C subunit 2-like K10755 RFC2_4; replication factor C subunit 2/4
D 127006203 replication factor C subunit 4-like K10755 RFC2_4; replication factor C subunit 2/4
D 126998509 replication factor C subunit 3-like K10756 RFC3_5; replication factor C subunit 3/5
D 127001489 replication factor C subunit 5-like K10756 RFC3_5; replication factor C subunit 3/5
C Rad17-Mec3-Ddc1 complex
D 126996727 cell cycle checkpoint protein RAD1-like K02830 HRAD1; cell cycle checkpoint protein [EC:3.1.11.2]
C FPC (fork protection complex)
D 126983504 protein timeless homolog K10997 TIMELESS; replication fork protection complex subunit TIMELESS/Tof1/Swi1
C Triple T complex
C BAG6-UBL4A-GET4 complex
D 127005191 ubiquitin-like protein 4A K23388 UBL4; ubiquitin-like protein 4
D 126992050 Golgi to ER traffic protein 4 homolog K23387 GET4; golgi to ER traffic protein 4
D 126994479 Golgi to ER traffic protein 4 homolog K23387 GET4; golgi to ER traffic protein 4
C Other check point factors
D 126981103 serine/threonine-protein kinase ATR-like isoform X1 K06640 ATR; serine/threonine-protein kinase ATR [EC:2.7.11.1]
D 127003056 serine/threonine-protein kinase grp-like K02216 CHEK1; serine/threonine-protein kinase CHEK1 [EC:2.7.11.1]
D 127000315 myosin light chain kinase A-like K06641 CHEK2; serine/threonine-protein kinase CHEK2 [EC:2.7.11.1]
D 126987999 14-3-3 protein zeta isoform X1 K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
D 126996014 14-3-3 protein epsilon isoform X1 K06630 YWHAE; 14-3-3 protein epsilon
D 127006715 protein sickie-like isoform X1 K19483 NAV2; neuron navigator 2 [EC:5.6.2.4]
D 126998961 wee1-like protein kinase 2 isoform X1 K06632 WEE1; wee1-like protein kinase [EC:2.7.11.1]
D 127004981 period circadian protein-like isoform X1 K02633 PER2; period circadian protein 2
D 126984233 plastin-2-like K17336 PLS3; plastin-3
D 127009922 protein downstream neighbor of son homolog K22422 DONSON; protein downstream neighbor of Son
D 126982179 vacuolar protein sorting-associated protein 4-like K12196 VPS4; vacuolar protein-sorting-associated protein 4
B Other factors with a suspected DNA repair function
C DNA polymerases
D 126980335 DNA-directed primase/polymerase protein-like K22761 PRIMPOL; DNA-directed primase/polymerase protein [EC:2.7.7.102 2.7.7.7]
C Nucleases
D 126999685 three-prime repair exonuclease 1-like K10790 TREX1; three prime repair exonuclease 1 [EC:3.1.11.2]
D 127007392 5' exonuclease Apollo-like K15341 DCLRE1B; DNA cross-link repair 1B protein [EC:3.1.-.-]
C Helicases
D 126997579 helicase POLQ-like isoform X1 K19178 HELQ; POLQ-like helicase [EC:5.6.2.4]
C PSO4 complex
D 126992049 pre-mRNA-processing factor 19-like K10599 PRPF19; pre-mRNA-processing factor 19 [EC:2.3.2.27]
D 126994503 pre-mRNA-processing factor 19-like K10599 PRPF19; pre-mRNA-processing factor 19 [EC:2.3.2.27]
D 126989690 cell division cycle 5-like protein K12860 CDC5L; pre-mRNA-splicing factor CDC5/CEF1
D 127009536 pre-mRNA-splicing factor SPF27-like K12861 BCAS2; pre-mRNA-splicing factor SPF27
D 127008124 pleiotropic regulator 1-like K12862 PLRG1; pleiotropic regulator 1
C Modulation of nucleotide pools
D 126997283 oxidized purine nucleoside triphosphate hydrolase-like K17816 NUDT1; 8-oxo-dGTP diphosphatase / 2-hydroxy-dATP diphosphatase [EC:3.6.1.55 3.6.1.56]
D 127007813 8-oxo-dGDP phosphatase NUDT18-like isoform X1 K17817 NUDT18; 8-oxo-dGDP phosphatase [EC:3.6.1.58]
D 126985385 deoxyuridine 5'-triphosphate nucleotidohydrolase-like K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 127007320 ribonucleoside-diphosphate reductase large subunit-like K10807 RRM1; ribonucleoside-diphosphate reductase subunit M1 [EC:1.17.4.1]
D 126984210 ribonucleoside-diphosphate reductase subunit M2 B-like isoform X1 K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]
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AProkaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D 127001617 methylated-DNA--protein-cysteine methyltransferase-like K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
D 126982009 deoxyribodipyrimidine photo-lyase-like K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]
C BER (base exicision repair)
D DNA glycosylases
E 126985898 single-strand selective monofunctional uracil DNA glycosylase-like K10800 SMUG1; single-strand selective monofunctional uracil DNA glycosylase [EC:3.2.2.-]
E 127010215 DNA-3-methyladenine glycosylase-like K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]
E 127006552 adenine DNA glycosylase-like isoform X1 K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
D AP endonucleases
D RecJ
D DNA ligase
D DNA polymerase I
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase complex (RNAP)
E TRCF (transcription-repair coupling factor)
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
D Molecular matchmaker
D Strand discrimination factor
D DNA exonucleases
D DNA polymerase III holoenzyme
D DNA ligase
D Other MMR factors
E 126998358 single-stranded DNA-binding protein, mitochondrial-like isoform X1 K03111 ssb; single-strand DNA-binding protein
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D RecBC pathway proteins
D RecFOR pathway proteins
D AddAB pathway proteins
D Other HR factor
D Archaeal homologous recombinant proteins
C NHEJ (non-homologous end-joining)
D Two-component NHEJ DNA repair complex
D SHIIR (short-homology-independent illegitimate recombination)
E Facilitator
E Supressor
D SHDIR (short-homology-dependent illegitimate recombination)
E RecET pathway
E Facilitator
E Supressor
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
C Other SOS response factors
D 126998358 single-stranded DNA-binding protein, mitochondrial-like isoform X1 K03111 ssb; single-strand DNA-binding protein
B Other factors with a suspected DNA repair function
C DNA polymerase
C DNA helicases
C Modulation of nucleotide pools
D 126985385 deoxyuridine 5'-triphosphate nucleotidohydrolase-like K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
C Others
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: March 29, 2024