+F Repair protein KO
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DNA Repair and Recombination Proteins - Eubacterium siraeum 70/3
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AEukaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D EUS_23080 O-6-methylguanine DNA methyltransferase K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
C BER (base exicision repair)
D DNA glycosylases
E EUS_25360 Uracil-DNA glycosylase K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E EUS_25370 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase K03660 OGG1; N-glycosylase/DNA lyase [EC:3.2.2.- 4.2.99.18]
E EUS_16220 endonuclease III K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
D Long Patch-BER factors
E DNA polymerase delta complex
E DNA polymerase epsilon complex
D Short Patch-BER factors
D Other BER factors
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E XPC-HR23B-CETN2 complex
E Cul4-DDB2 complex
E NER4 complex
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase II complex
E Cul4-CSA complex
E Other TCR factor
D TFIIH complex
D RPA (replication factor A)
D Other NER factors
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
D MutL homologs
D DNA polymerase delta complex
D RPA (replication factor A)
D RFC (replication factor C)
D Other MMR factors
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D MRN(MRX) complex
D BRCA1-core complex
D BRCA1-A complex
D BRCA1-B complex
D BRCA1-C complex
D BRCA complex
D RecA family proteins
D Rad52 family proteins
D Rad54 family proteins
D RecQ family DNA helicases
D Bloom's syndrome complex (BTR)
D RPA (replication factor A)
D Protein phosphatase 4
D AP-5 complex
D SMC5-SMC6 complex
D Other HR factors
C NHEJ (non-homologous end-joining)
D DNA-PK complex
D MRX complex
D DNA Ligase 4 complex
D X-family DNA polymerases
D Other NHEJ factors
C FA (Fanconi anemia) pathway
D FA core complex
D FA core complex binding factors
D Bloom's syndrome complex (BTR)
D FANCD2-I complex
D Downstream FA components
D Other FA pathway factors
C Other DSBR factors
D Protein phosphatase 6
D Ubiquitin ligases
D Others
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
C B-family DNA polymerases
C A-family DNA polymerase
C Rad6 epistasis group
C Other TLS factors
B Check point factors
C Rad9-Hus1-Rad1 complex
C HRAD17(Rad24)-RFC complex
C Rad17-Mec3-Ddc1 complex
C FPC (fork protection complex)
C Triple T complex
C BAG6-UBL4A-GET4 complex
C Other check point factors
B Other factors with a suspected DNA repair function
C DNA polymerases
C Nucleases
C Helicases
C PSO4 complex
C Modulation of nucleotide pools
D EUS_18450 NTP pyrophosphohydrolases including oxidative damage repair enzymes K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D EUS_14670 deoxyuridine 5'-triphosphate nucleotidohydrolase K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
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AProkaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D EUS_23080 O-6-methylguanine DNA methyltransferase K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
C BER (base exicision repair)
D DNA glycosylases
E EUS_25360 Uracil-DNA glycosylase K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E EUS_13980 G:T/U mismatch-specific DNA glycosylase K03649 mug; double-stranded uracil-DNA glycosylase [EC:3.2.2.28]
E EUS_16220 endonuclease III K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
E EUS_05940 Endonuclease IV K01151 nfo; deoxyribonuclease IV [EC:3.1.21.2]
D RecJ
E EUS_15020 single-stranded-DNA-specific exonuclease RecJ K07462 recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-]
D DNA ligase
E EUS_11250 DNA ligase, NAD-dependent K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
D DNA polymerase I
E EUS_22250 DNA polymerase I K02335 polA; DNA polymerase I [EC:2.7.7.7]
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E EUS_13690 Excinuclease ABC subunit A K03701 uvrA; excinuclease ABC subunit A
E EUS_13700 Excinuclease ABC subunit B K03702 uvrB; excinuclease ABC subunit B
E EUS_15790 Excinuclease ABC subunit C K03703 uvrC; excinuclease ABC subunit C
E EUS_01410 ATP-dependent DNA helicase PcrA K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E EUS_17220 Superfamily I DNA and RNA helicases K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E EUS_20670 Superfamily I DNA and RNA helicases K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E EUS_22250 DNA polymerase I K02335 polA; DNA polymerase I [EC:2.7.7.7]
E EUS_11250 DNA ligase, NAD-dependent K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase complex (RNAP)
F EUS_14870 DNA-directed RNA polymerase subunit beta K03043 rpoB; DNA-directed RNA polymerase subunit beta [EC:2.7.7.6]
F EUS_27900 DNA-directed RNA polymerase subunit alpha K03040 rpoA; DNA-directed RNA polymerase subunit alpha [EC:2.7.7.6]
F EUS_15530 hypothetical protein K03048 rpoE; DNA-directed RNA polymerase subunit delta
E TRCF (transcription-repair coupling factor)
F EUS_22490 transcription-repair coupling factor K03723 mfd; transcription-repair coupling factor (superfamily II helicase) [EC:5.6.2.4]
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
E EUS_05540 DNA mismatch repair protein MutS K03555 mutS; DNA mismatch repair protein MutS
E EUS_08090 Mismatch repair ATPase (MutS family) K03555 mutS; DNA mismatch repair protein MutS
E EUS_11980 MutS2 family protein K07456 mutS2; DNA mismatch repair protein MutS2
D Molecular matchmaker
E EUS_05550 DNA mismatch repair protein MutL K03572 mutL; DNA mismatch repair protein MutL
D Strand discrimination factor
D DNA exonucleases
E EUS_15320 exodeoxyribonuclease VII, large subunit K03601 xseA; exodeoxyribonuclease VII large subunit [EC:3.1.11.6]
E EUS_15310 Exonuclease VII small subunit. K03602 xseB; exodeoxyribonuclease VII small subunit [EC:3.1.11.6]
D DNA polymerase III holoenzyme
E EUS_07900 DNA polymerase III catalytic subunit, PolC type K03763 polC; DNA polymerase III subunit alpha, Gram-positive type [EC:2.7.7.7]
E EUS_25900 DNA polymerase III, beta subunit K02338 dnaN; DNA polymerase III subunit beta [EC:2.7.7.7]
E EUS_09230 DNA polymerase III, delta subunit K02340 holA; DNA polymerase III subunit delta [EC:2.7.7.7]
E EUS_02030 hypothetical protein K02341 holB; DNA polymerase III subunit delta' [EC:2.7.7.7]
E EUS_17230 exonuclease, DNA polymerase III, epsilon subunit family K02342 dnaQ; DNA polymerase III subunit epsilon [EC:2.7.7.7]
E EUS_21200 exonuclease, DNA polymerase III, epsilon subunit family K02342 dnaQ; DNA polymerase III subunit epsilon [EC:2.7.7.7]
D DNA ligase
E EUS_11250 DNA ligase, NAD-dependent K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
D Other MMR factors
E EUS_01410 ATP-dependent DNA helicase PcrA K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E EUS_17220 Superfamily I DNA and RNA helicases K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E EUS_20670 Superfamily I DNA and RNA helicases K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E EUS_12480 single stranded DNA-binding protein (ssb) K03111 ssb; single-strand DNA-binding protein
E EUS_06280 Site-specific DNA methylase K06223 dam; DNA adenine methylase [EC:2.1.1.72]
E EUS_09800 Site-specific DNA methylase K06223 dam; DNA adenine methylase [EC:2.1.1.72]
E EUS_22040 DNA adenine methylase (dam) K06223 dam; DNA adenine methylase [EC:2.1.1.72]
E EUS_06780 T/G mismatch-specific endonuclease K07458 vsr; DNA mismatch endonuclease, patch repair protein [EC:3.1.-.-]
E EUS_17990 T/G mismatch-specific endonuclease K07458 vsr; DNA mismatch endonuclease, patch repair protein [EC:3.1.-.-]
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D RecBC pathway proteins
E EUS_25200 protein RecA K03553 recA; recombination protein RecA
E EUS_12670 Holliday junction DNA helicase subunit RuvA K03550 ruvA; holliday junction DNA helicase RuvA
E EUS_12660 Holliday junction DNA helicase, RuvB subunit K03551 ruvB; holliday junction DNA helicase RuvB [EC:5.6.2.4]
E EUS_12680 crossover junction endodeoxyribonuclease RuvC K01159 ruvC; crossover junction endodeoxyribonuclease RuvC [EC:3.1.21.10]
E EUS_09630 primosomal protein N' K04066 priA; primosomal protein N' (replication factor Y) (superfamily II helicase) [EC:5.6.2.4]
D RecFOR pathway proteins
E EUS_25200 protein RecA K03553 recA; recombination protein RecA
E EUS_00800 DNA repair protein RadA K04485 radA; DNA repair protein RadA/Sms
E EUS_25860 recF protein K03629 recF; DNA replication and repair protein RecF
E EUS_14350 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen K03655 recG; ATP-dependent DNA helicase RecG [EC:5.6.2.4]
E EUS_15510 ATP-dependent DNA helicase RecG K03655 recG; ATP-dependent DNA helicase RecG [EC:5.6.2.4]
E EUS_15020 single-stranded-DNA-specific exonuclease RecJ K07462 recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-]
E EUS_11990 DNA repair protein RecO K03584 recO; DNA repair protein RecO (recombination protein O)
E EUS_26700 recombination protein RecR K06187 recR; recombination protein RecR
E EUS_12670 Holliday junction DNA helicase subunit RuvA K03550 ruvA; holliday junction DNA helicase RuvA
E EUS_12660 Holliday junction DNA helicase, RuvB subunit K03551 ruvB; holliday junction DNA helicase RuvB [EC:5.6.2.4]
E EUS_12680 crossover junction endodeoxyribonuclease RuvC K01159 ruvC; crossover junction endodeoxyribonuclease RuvC [EC:3.1.21.10]
D AddAB pathway proteins
E EUS_23170 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) K16898 addA; ATP-dependent helicase/nuclease subunit A [EC:5.6.2.4 3.1.-.-]
E EUS_23180 ATP-dependent nuclease, subunit B K16899 addB; ATP-dependent helicase/nuclease subunit B [EC:5.6.2.4 3.1.-.-]
D Other HR factor
D Archaeal homologous recombinant proteins
C NHEJ (non-homologous end-joining)
D Two-component NHEJ DNA repair complex
D SHIIR (short-homology-independent illegitimate recombination)
E Facilitator
F EUS_25810 DNA gyrase subunit A K02469 gyrA; DNA gyrase subunit A [EC:5.6.2.2]
F EUS_00330 Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit K02470 gyrB; DNA gyrase subunit B [EC:5.6.2.2]
F EUS_25840 DNA gyrase subunit B K02470 gyrB; DNA gyrase subunit B [EC:5.6.2.2]
E Supressor
F EUS_11480 bacterial nucleoid protein Hbs K03530 hupB; DNA-binding protein HU-beta
D SHDIR (short-homology-dependent illegitimate recombination)
E RecET pathway
F EUS_15020 single-stranded-DNA-specific exonuclease RecJ K07462 recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-]
F EUS_11990 DNA repair protein RecO K03584 recO; DNA repair protein RecO (recombination protein O)
F EUS_26700 recombination protein RecR K06187 recR; recombination protein RecR
F EUS_11250 DNA ligase, NAD-dependent K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
E Facilitator
E Supressor
F EUS_13690 Excinuclease ABC subunit A K03701 uvrA; excinuclease ABC subunit A
F EUS_13700 Excinuclease ABC subunit B K03702 uvrB; excinuclease ABC subunit B
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
C Other SOS response factors
D EUS_25200 protein RecA K03553 recA; recombination protein RecA
D EUS_10230 SOS-response transcriptional repressors (RecA-mediated autopeptidases) K01356 lexA; repressor LexA [EC:3.4.21.88]
D EUS_12480 single stranded DNA-binding protein (ssb) K03111 ssb; single-strand DNA-binding protein
D EUS_25210 Uncharacterized protein conserved in bacteria K03565 recX; regulatory protein
B Other factors with a suspected DNA repair function
C DNA polymerase
C DNA helicases
D EUS_10310 Rad3-related DNA helicases K03722 dinG; ATP-dependent DNA helicase DinG [EC:5.6.2.3]
C Modulation of nucleotide pools
D EUS_18450 NTP pyrophosphohydrolases including oxidative damage repair enzymes K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D EUS_14670 deoxyuridine 5'-triphosphate nucleotidohydrolase K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
C Others
D EUS_22690 Exopolyphosphatase-related proteins K06881 nrnA; bifunctional oligoribonuclease and PAP phosphatase NrnA [EC:3.1.3.7 3.1.13.3]
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: March 29, 2024