+E Replication protein KO
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DNA Replication Proteins - Felis catus (domestic cat)
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AEukaryotic type
B DNA Replication Initiation Factors
C pre-RC (pre-replication complex)
D 101090883 ORC1; origin recognition complex subunit 1 isoform X1 K02603 ORC1; origin recognition complex subunit 1
D 101085739 ORC2; origin recognition complex subunit 2 K02604 ORC2; origin recognition complex subunit 2
D 101090017 ORC3; origin recognition complex subunit 3 isoform X1 K02605 ORC3; origin recognition complex subunit 3
D 101097998 ORC4; origin recognition complex subunit 4 isoform X1 K02606 ORC4; origin recognition complex subunit 4
D 101085449 ORC5; origin recognition complex subunit 5 isoform X1 K02607 ORC5; origin recognition complex subunit 5
D 101087628 ORC6; origin recognition complex subunit 6 isoform X1 K02608 ORC6; origin recognition complex subunit 6
D 101098673 CDT1; DNA replication factor Cdt1 K10727 CDT1; chromatin licensing and DNA replication factor 1
D 101082791 CDC6; cell division control protein 6 homolog isoform X1 K02213 CDC6; cell division control protein 6
D 101090176 MCM2; DNA replication licensing factor MCM2 K02540 MCM2; DNA replication licensing factor MCM2 [EC:5.6.2.3]
D 101083515 MCM3; DNA replication licensing factor MCM3 K02541 MCM3; DNA replication licensing factor MCM3 [EC:5.6.2.3]
D 101089576 MCM4; DNA replication licensing factor MCM4 isoform X2 K02212 MCM4; DNA replication licensing factor MCM4 [EC:5.6.2.3]
D 101092865 MCM5; DNA replication licensing factor MCM5 isoform X1 K02209 MCM5; DNA replication licensing factor MCM5 [EC:5.6.2.3]
D 101092703 MCM6; DNA replication licensing factor MCM6 K02542 MCM6; DNA replication licensing factor MCM6 [EC:5.6.2.3]
D 101088383 MCM7; DNA replication licensing factor MCM7 isoform X1 K02210 MCM7; DNA replication licensing factor MCM7 [EC:5.6.2.3]
C CDK (cyclin dependent kinase)
D 101088573 CCNA2; cyclin-A2 K06627 CCNA; cyclin-A
D 101085426 CCNA1; cyclin-A1 isoform X1 K06627 CCNA; cyclin-A
D 101086192 CCNE1; G1/S-specific cyclin-E1 isoform X1 K06626 CCNE; G1/S-specific cyclin-E1
D 101085347 CCNE2; G1/S-specific cyclin-E2 isoform X1 K06626 CCNE; G1/S-specific cyclin-E1
D 101093368 CDK2; cyclin-dependent kinase 2 isoform X2 K02206 CDK2; cyclin-dependent kinase 2 [EC:2.7.11.22]
C DDK (Dbf-4 dependent kinase)
D 101085227 CDC7; cell division cycle 7-related protein kinase isoform X1 K02214 CDC7; cell division control protein 7 [EC:2.7.11.1]
D 101098126 DBF4; protein DBF4 homolog A isoform X1 K06629 DBF4; protein DBF4
D 101085761 DBF4B; LOW QUALITY PROTEIN: protein DBF4 homolog B K06629 DBF4; protein DBF4
C GINS complex
D 101091610 GINS1; DNA replication complex GINS protein PSF1 isoform X1 K10732 GINS1; GINS complex subunit 1
D 101089666 GINS2; DNA replication complex GINS protein PSF2 K10733 GINS2; GINS complex subunit 2
D 101088800 GINS3; DNA replication complex GINS protein PSF3 K10734 GINS3; GINS complex subunit 3
D 101082647 GINS4; DNA replication complex GINS protein SLD5 isoform X1 K10735 GINS4; GINS complex subunit 4
C Other initiation factors
D 101085568 TOPBP1; DNA topoisomerase 2-binding protein 1 isoform X1 K10728 TOPBP1; topoisomerase (DNA) II binding protein 1
D 101097700 RECQL4; LOW QUALITY PROTEIN: ATP-dependent DNA helicase Q4 K10730 RECQL4; ATP-dependent DNA helicase Q4 [EC:5.6.2.4]
D 101097519 CDC45; cell division control protein 45 homolog isoform X1 K06628 CDC45; cell division control protein 45
D 101088566 MCM8; DNA helicase MCM8 isoform X1 K10737 MCM8; DNA helicase MCM8 [EC:5.6.2.4]
D 101098953 MCM9; DNA helicase MCM9 isoform X2 K10738 MCM9; DNA helicase MCM9 [EC:5.6.2.4]
D 101097738 MCM10; protein MCM10 homolog isoform X2 K10736 MCM10; minichromosome maintenance protein 10
D 101090530 HELB; DNA helicase B isoform X1 K15254 HELB; DNA helicase B [EC:5.6.2.3]
D 101098490 FAM111A; serine protease FAM111A K24274 FAM111A; protein FAM111A
D 101083600 CINP; cyclin-dependent kinase 2-interacting protein isoform X2 K26052 CINP; cyclin-dependent kinase 2-interacting protein
D 101099179 MTBP; mdm2-binding protein isoform X1 K26116 MTBP; Mdm2-binding protein
D 101090870 TICRR; treslin isoform X1 K26117 TICRR; Treslin
B DNA Replication Elongation Factors
C DNA polymerase alpha / primase complex
D 101098929 POLA1; DNA polymerase alpha catalytic subunit isoform X2 K02320 POLA1; DNA polymerase alpha subunit A [EC:2.7.7.7]
D 101084827 POLA2; DNA polymerase alpha subunit B isoform X1 K02321 POLA2; DNA polymerase alpha subunit B
D 101080554 PRIM1; DNA primase small subunit K02684 PRI1; DNA primase small subunit [EC:2.7.7.102]
D 101098711 PRIM2; DNA primase large subunit isoform X1 K02685 PRI2; DNA primase large subunit
C DNA polymerase epsilon complex
D 101096921 POLE; DNA polymerase epsilon catalytic subunit A isoform X1 K02324 POLE; DNA polymerase epsilon subunit 1 [EC:2.7.7.7]
D 101092770 POLE2; DNA polymerase epsilon subunit 2 isoform X1 K02325 POLE2; DNA polymerase epsilon subunit 2 [EC:2.7.7.7]
D 101097106 POLE3; DNA polymerase epsilon subunit 3 K02326 POLE3; DNA polymerase epsilon subunit 3 [EC:2.7.7.7]
D 101089849 POLE4; DNA polymerase epsilon subunit 4 isoform X3 K03506 POLE4; DNA polymerase epsilon subunit 4 [EC:2.7.7.7]
C DNA polymerase delta complex
D 101086519 POLD1; DNA polymerase delta catalytic subunit isoform X2 K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
D 101095089 POLD2; DNA polymerase delta subunit 2 K02328 POLD2; DNA polymerase delta subunit 2
D 101093711 POLD3; DNA polymerase delta subunit 3 isoform X1 K03504 POLD3; DNA polymerase delta subunit 3
D 101091308 POLD4; DNA polymerase delta subunit 4 K03505 POLD4; DNA polymerase delta subunit 4
C DNA polymerase gamma complex (mitochondrial)
D 101083771 POLG; DNA polymerase subunit gamma-1 isoform X3 K02332 POLG; DNA polymerase gamma 1 [EC:2.7.7.7]
D 101084917 POLG2; DNA polymerase subunit gamma-2, mitochondrial isoform X1 K02333 POLG2; DNA polymerase gamma 2
C RPA (replication protein A)
D 101084325 RPA1; replication protein A 70 kDa DNA-binding subunit K07466 RFA1; replication factor A1
D 101084979 RPA2; replication protein A 32 kDa subunit K10739 RFA2; replication factor A2
D 101097223 RPA3; replication protein A 14 kDa subunit K10740 RPA3; replication factor A3
C RFC (replication factor C)
D 101094345 RFC1; replication factor C subunit 1 K10754 RFC1; replication factor C subunit 1
D 101098886 RFC4; replication factor C subunit 4 isoform X1 K10755 RFC2_4; replication factor C subunit 2/4
D 101094392 RFC2; replication factor C subunit 2 K10755 RFC2_4; replication factor C subunit 2/4
D 101092297 RFC5; replication factor C subunit 5 K10756 RFC3_5; replication factor C subunit 3/5
D 101081597 RFC3; replication factor C subunit 3 isoform X1 K10756 RFC3_5; replication factor C subunit 3/5
C RNase H
D 101097476 RNASEH1; ribonuclease H1 K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
D 101086121 RNASEH2A; ribonuclease H2 subunit A isoform X1 K10743 RNASEH2A; ribonuclease H2 subunit A [EC:3.1.26.4]
D 101098842 RNASEH2B; ribonuclease H2 subunit B isoform X1 K10744 RNASEH2B; ribonuclease H2 subunit B
D 101100003 RNASEH2C; ribonuclease H2 subunit C K10745 RNASEH2C; ribonuclease H2 subunit C
C Other elongation factors
D 101080704 PCNA; proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
D 101097671 DNA2; DNA replication ATP-dependent helicase/nuclease DNA2 isoform X1 K10742 DNA2; DNA replication ATP-dependent helicase/nuclease Dna2 [EC:5.6.2.3 3.1.-.-]
D 101083708 FEN1; flap endonuclease 1 K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
D 101093573 EXO1; exonuclease 1 isoform X1 K10746 EXO1; exonuclease 1 [EC:3.1.-.-]
D 101093202 ZRANB3; DNA annealing helicase and endonuclease ZRANB3 isoform X1 K25861 ZRANB3; DNA annealing helicase and endonuclease ZRANB3 [EC:5.6.2.- 3.1.-.-]
D 101093313 LIG1; DNA ligase 1 isoform X4 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
D 101093407 ATAD5; ATPase family AAA domain-containing protein 5 isoform X1 K26118 ATAD5; ATPase family AAA domain-containing protein 5
B DNA Replication Termination Factors
C DNA methylation enzymes
D 101093502 DNMT1; DNA (cytosine-5)-methyltransferase 1 isoform X4 K00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]
D 100510798 DNMT3A; DNA (cytosine-5)-methyltransferase 3A K17398 DNMT3A; DNA (cytosine-5)-methyltransferase 3A [EC:2.1.1.37]
D 101092926 DNMT3B; DNA (cytosine-5)-methyltransferase 3B isoform X5 K17399 DNMT3B; DNA (cytosine-5)-methyltransferase 3B [EC:2.1.1.37]
C Prevention of re-replication factors
D 101097559 GMNN; geminin K10749 GMNN; geminin
D 101087810 MCIDAS; multicilin K26119 MCIDAS; multicilin
D 101086284 CCNB1; G2/mitotic-specific cyclin-B1 isoform X1 K05868 CCNB1; G2/mitotic-specific cyclin-B1
D 102900567 LOW QUALITY PROTEIN: G2/mitotic-specific cyclin-B1-like K05868 CCNB1; G2/mitotic-specific cyclin-B1
D 101080972 CCNB2; G2/mitotic-specific cyclin-B2 isoform X3 K21770 CCNB2; G2/mitotic-specific cyclin-B2
D 101081785 CCNB3; G2/mitotic-specific cyclin-B3 isoform X1 K21771 CCNB3; G2/mitotic-specific cyclin-B3
D 101101592 CDK1; cyclin-dependent kinase 1 K02087 CDK1; cyclin-dependent kinase 1 [EC:2.7.11.22 2.7.11.23]
C Telomere proteins
D Shelterin complex
E 101097225 POT1; protection of telomeres protein 1 isoform X1 K11109 POT1; protection of telomeres protein 1
E 101098684 TERF1; telomeric repeat-binding factor 1 isoform X3 K11110 TERF1; telomeric repeat-binding factor 1
E 101083387 TERF2; telomeric repeat-binding factor 2 isoform X1 K11111 TERF2; telomeric repeat-binding factor 2
E 101081811 TINF2; TERF1-interacting nuclear factor 2 isoform X4 K11112 TINF2; TERF1-interacting nuclear factor 2
E 101097610 TERF2IP; telomeric repeat-binding factor 2-interacting protein 1 K11113 TERF2IP; telomeric repeat-binding factor 2-interacting protein 1
E 101090066 ACD; adrenocortical dysplasia protein homolog isoform X3 K11114 ACD; adrenocortical dysplasia protein
D TERB1-TERB2-MAJIN complex
E 101086273 TERB1; telomere repeats-binding bouquet formation protein 1 isoform X1 K25749 TERB1; telomere repeats-binding bouquet formation protein 1
E 101088582 TERB2; telomere repeats-binding bouquet formation protein 2 isoform X1 K25750 TERB2; telomere repeats-binding bouquet formation protein 2
E 101095195 MAJIN; membrane-anchored junction protein isoform X1 K25751 MAJIN; membrane-anchored junction protein
D CST complex (animals)
E 101080587 CTC1; LOW QUALITY PROTEIN: CST complex subunit CTC1 K23311 CTC1; CST complex subunit CTC1
E 101088363 STN1; CST complex subunit STN1 isoform X1 K23312 STN1; CST complex subunit STN1
E 101080365 LOW QUALITY PROTEIN: CST complex subunit TEN1 K23313 TEN1; CST complex subunit TEN1
D CST complex (yeast)
D RIF proteins
D SIR proteins
C Telomerase complex (animals)
D 101099159 SMG6; telomerase-binding protein EST1A isoform X1 K11124 SMG6; protein SMG6 [EC:3.1.-.-]
D 101085434 SMG5; protein SMG5 isoform X3 K11125 SMG5; protein SMG5
D 100144612 TERT; telomerase reverse transcriptase isoform X1 K11126 TERT; telomerase reverse transcriptase [EC:2.7.7.49]
D 101091203 TEP1; telomerase protein component 1 isoform X1 K11127 TEP1; telomerase protein component 1
D Dyskerin complex
E 101083587 GAR1; H/ACA ribonucleoprotein complex subunit 1 K11128 GAR1; H/ACA ribonucleoprotein complex subunit 1
E 101088136 NHP2; H/ACA ribonucleoprotein complex subunit 2 K11129 NHP2; H/ACA ribonucleoprotein complex subunit 2
E 101098467 NOP10; H/ACA ribonucleoprotein complex subunit 3 K11130 NOP10; H/ACA ribonucleoprotein complex subunit 3
E 101085399 H/ACA ribonucleoprotein complex subunit 3-like K11130 NOP10; H/ACA ribonucleoprotein complex subunit 3
E 101096046 DKC1; H/ACA ribonucleoprotein complex subunit DKC1 K11131 DKC1; H/ACA ribonucleoprotein complex subunit 4 [EC:5.4.99.-]
C Telomerase complex (fungi)
D 100144612 TERT; telomerase reverse transcriptase isoform X1 K11126 TERT; telomerase reverse transcriptase [EC:2.7.7.49]
D Sm core complex
E 101099709 SNRPB; small nuclear ribonucleoprotein-associated proteins B and B' isoform X2 K11086 SNRPB; small nuclear ribonucleoprotein B and B'
E 101093553 SNRPD1; small nuclear ribonucleoprotein Sm D1 isoform X1 K11087 SNRPD1; small nuclear ribonucleoprotein D1
E 101093907 SNRPD2; small nuclear ribonucleoprotein Sm D2 K11096 SNRPD2; small nuclear ribonucleoprotein D2
E 101097968 small nuclear ribonucleoprotein Sm D3-like K11088 SNRPD3; small nuclear ribonucleoprotein D3
E 101081256 SNRPD3; small nuclear ribonucleoprotein Sm D3 K11088 SNRPD3; small nuclear ribonucleoprotein D3
E 493770 SNRPE; small nuclear ribonucleoprotein E isoform X2 K11097 SNRPE; small nuclear ribonucleoprotein E
E 101091795 SNRPF; small nuclear ribonucleoprotein F K11098 SNRPF; small nuclear ribonucleoprotein F
E 101091006 small nuclear ribonucleoprotein F-like K11098 SNRPF; small nuclear ribonucleoprotein F
E 101089093 small nuclear ribonucleoprotein F-like K11098 SNRPF; small nuclear ribonucleoprotein F
E 109500869 small nuclear ribonucleoprotein F K11098 SNRPF; small nuclear ribonucleoprotein F
E 101096882 SNRPG; small nuclear ribonucleoprotein G K11099 SNRPG; small nuclear ribonucleoprotein G
E 123379002 small nuclear ribonucleoprotein G-like K11099 SNRPG; small nuclear ribonucleoprotein G
E 109497201 small nuclear ribonucleoprotein G-like K11099 SNRPG; small nuclear ribonucleoprotein G
E 109501880 small nuclear ribonucleoprotein G-like K11099 SNRPG; small nuclear ribonucleoprotein G
E 109499203 small nuclear ribonucleoprotein G-like K11099 SNRPG; small nuclear ribonucleoprotein G
C ELG1-RFC complex
D 101098886 RFC4; replication factor C subunit 4 isoform X1 K10755 RFC2_4; replication factor C subunit 2/4
D 101094392 RFC2; replication factor C subunit 2 K10755 RFC2_4; replication factor C subunit 2/4
D 101092297 RFC5; replication factor C subunit 5 K10756 RFC3_5; replication factor C subunit 3/5
D 101081597 RFC3; replication factor C subunit 3 isoform X1 K10756 RFC3_5; replication factor C subunit 3/5
C MRN complex
D 101086923 MRE11; double-strand break repair protein MRE11 isoform X1 K10865 MRE11; double-strand break repair protein MRE11
D 101095875 RAD50; DNA repair protein RAD50 isoform X1 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
D 101087042 NBN; nibrin isoform X1 K10867 NBN; nibrin
C Other termination factors
D 101089291 ATM; serine-protein kinase ATM isoform X1 K04728 ATM; serine-protein kinase ATM [EC:2.7.11.1]
D 101095574 WRN; Werner syndrome ATP-dependent helicase isoform X1 K10900 WRN; werner syndrome ATP-dependent helicase [EC:5.6.2.4]
D 101100056 BLM; Bloom syndrome protein isoform X1 K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
D 101088389 PRKDC; DNA-dependent protein kinase catalytic subunit isoform X1 K06642 PRKDC; DNA-dependent protein kinase catalytic subunit [EC:2.7.11.1]
D 101100531 ERCC4; DNA repair endonuclease XPF K10848 ERCC4; DNA excision repair protein ERCC-4 [EC:3.1.-.-]
D 101081434 PARP1; poly [ADP-ribose] polymerase 1 isoform X1 K24070 PARP1; poly [ADP-ribose] polymerase 1 [EC:2.4.2.30]
D 101100038 PARP3; protein mono-ADP-ribosyltransferase PARP3 isoform X2 K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
D 101090944 PARP2; poly [ADP-ribose] polymerase 2 isoform X3 K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
D 101092074 PARP4; LOW QUALITY PROTEIN: protein mono-ADP-ribosyltransferase PARP4 K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
D 101093147 TNKS2; poly [ADP-ribose] polymerase tankyrase-2 isoform X2 K10799 TNKS; tankyrase [EC:2.4.2.30]
D 101092933 TNKS; poly [ADP-ribose] polymerase tankyrase-1 isoform X1 K10799 TNKS; tankyrase [EC:2.4.2.30]
D 101085626 PINX1; PIN2/TERF1-interacting telomerase inhibitor 1 isoform X1 K11135 PINX1; Pin2-interacting protein X1
D 101095970 RTEL1; regulator of telomere elongation helicase 1 isoform X1 K11136 RTEL1; regulator of telomere elongation helicase 1 [EC:5.6.2.3]
D 101085261 TELO2; telomere length regulation protein TEL2 homolog isoform X2 K11137 TELO2; telomere length regulation protein
D 105261225 TRIR; telomerase RNA component interacting RNase isoform X1 K01149 TRIR; telomerase RNA component interacting RNase [EC:3.1.13.-]
D 101101071 RIF1; telomere-associated protein RIF1 isoform X1 K11138 RIF1; telomere-associated protein RIF1
D 101086314 PIF1; ATP-dependent DNA helicase PIF1 isoform X5 K15255 PIF1; ATP-dependent DNA helicase PIF1 [EC:5.6.2.3]
D 101091249 PURA; transcriptional activator protein Pur-alpha K21772 PURA; transcriptional activator protein Pur-alpha
D 101091015 PURG; purine-rich element-binding protein gamma isoform X2 K21800 PURG; purine-rich element-binding protein gamma
D 101099509 WRAP53; telomerase Cajal body protein 1 K23314 WRAP53; telomerase Cajal body protein 1
D 101086529 SDE2; replication stress response regulator SDE2 K25059 SDE2; replication stress response regulator SDE2
D 101090429 RTF2; replication termination factor 2 isoform X3 K25186 RTF2; replication termination factor 2
B DNA Topoisomerases
C 101093174 TOP1; DNA topoisomerase 1 K03163 TOP1; DNA topoisomerase I [EC:5.6.2.1]
C 101083813 TOP2A; DNA topoisomerase 2-alpha K03164 TOP2; DNA topoisomerase II [EC:5.6.2.2]
C 101088949 TOP2B; DNA topoisomerase 2-beta isoform X1 K03164 TOP2; DNA topoisomerase II [EC:5.6.2.2]
C 101086515 TOP3A; DNA topoisomerase 3-alpha isoform X1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
C 101088117 TOP3B; DNA topoisomerase 3-beta-1 isoform X1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
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AProkaryotic type
B DNA Replication Initiation Factors
C Initiation factors (bacterial)
D 101083159 SSBP1; single-stranded DNA-binding protein, mitochondrial isoform X4 K03111 ssb; single-strand DNA-binding protein
C Initiation factors (archaeal)
B DNA Replication Elongation Factors
C Elongation factors (bacterial)
D DNA polymerase III holoenzyme
D RNase H
E 101097476 RNASEH1; ribonuclease H1 K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
D Other elongation factors
C Elongation factors (archaeal)
D B-family DNA polymerases
D D-family DNA polymerases
D RNase H
E 101097476 RNASEH1; ribonuclease H1 K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
D RFC (replication factor C)
D Other elongation factors
E 101097671 DNA2; DNA replication ATP-dependent helicase/nuclease DNA2 isoform X1 K10742 DNA2; DNA replication ATP-dependent helicase/nuclease Dna2 [EC:5.6.2.3 3.1.-.-]
E 101083708 FEN1; flap endonuclease 1 K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
E 101093313 LIG1; DNA ligase 1 isoform X4 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
B DNA Replication Termination Factors
C Terminus site-binding protein
C DNA methylation enzymes
C Prevention of re-replication factors
B DNA Topoisomerases
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: November 2, 2022