+F Repair protein KO
#
DNA Repair and Recombination Proteins - Frankliniella occidentalis (western flower thrips)
%
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AEukaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D 113203291 methylated-DNA--protein-cysteine methyltransferase K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
D 113206052 gastrula zinc finger protein XlCGF57.1-like isoform X4 K10859 ALKBH2; DNA oxidative demethylase [EC:1.14.11.33]
D 113204129 activating signal cointegrator 1 complex subunit 3 K18663 ASCC3; activating signal cointegrator complex subunit 3 [EC:5.6.2.4]
D 113204870 deoxyribodipyrimidine photo-lyase-like K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]
C BER (base exicision repair)
D DNA glycosylases
E 113203580 uracil-DNA glycosylase-like K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E 113202449 uncharacterized protein LOC113202449 isoform X1 K20813 TDG; thymine-DNA glycosylase [EC:3.2.2.29]
E 113208876 DNA-3-methyladenine glycosylase K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]
E 113211036 single-strand selective monofunctional uracil DNA glycosylase-like isoform X1 K10800 SMUG1; single-strand selective monofunctional uracil DNA glycosylase [EC:3.2.2.-]
E 113209396 adenine DNA glycosylase-like K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
E 113212695 N-glycosylase/DNA lyase K03660 OGG1; N-glycosylase/DNA lyase [EC:3.2.2.- 4.2.99.18]
E 113208430 endonuclease 8-like 3 K10569 NEIL3; endonuclease VIII-like 3 [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
E 113210259 DNA-(apurinic or apyrimidinic site) endonuclease K10771 APEX1; AP endonuclease 1 [EC:3.1.11.2]
E 113211494 DNA-(apurinic or apyrimidinic site) endonuclease 2-like K10772 APEX2; AP endonuclease 2 [EC:3.1.11.2]
D Long Patch-BER factors
E DNA polymerase delta complex
F 113213059 DNA polymerase delta catalytic subunit isoform X1 K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
F 113210025 DNA polymerase delta subunit 2 K02328 POLD2; DNA polymerase delta subunit 2
F 113207544 DNA polymerase delta subunit 3 K03504 POLD3; DNA polymerase delta subunit 3
E DNA polymerase epsilon complex
F 113207889 DNA polymerase epsilon catalytic subunit 1 K02324 POLE; DNA polymerase epsilon subunit 1 [EC:2.7.7.7]
F 113207849 DNA polymerase epsilon subunit 2 K02325 POLE2; DNA polymerase epsilon subunit 2 [EC:2.7.7.7]
F 113210778 DNA polymerase epsilon subunit 3 K02326 POLE3; DNA polymerase epsilon subunit 3 [EC:2.7.7.7]
F 113213231 DNA polymerase epsilon subunit 4 K03506 POLE4; DNA polymerase epsilon subunit 4 [EC:2.7.7.7]
E 113203395 proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
E 113207777 flap endonuclease 1 K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
E 113202179 flap endonuclease 1-like K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
E 113216090 DNA ligase 1 isoform X1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
D Short Patch-BER factors
E 113203287 DNA polymerase beta K02330 POLB; DNA polymerase beta [EC:2.7.7.7 4.2.99.-]
E 113214764 uncharacterized protein LOC113214764 isoform X1 K10803 XRCC1; DNA-repair protein XRCC1
E 113210012 DNA repair protein XRCC1 K10803 XRCC1; DNA-repair protein XRCC1
E 113202535 DNA repair protein XRCC1-like K10803 XRCC1; DNA-repair protein XRCC1
E 113208718 DNA ligase 3 K10776 LIG3; DNA ligase 3 [EC:6.5.1.1]
D Other BER factors
E 113207899 probable tyrosyl-DNA phosphodiesterase K10862 TDP1; tyrosyl-DNA phosphodiesterase 1 [EC:3.1.4.-]
E 113204005 aprataxin K10863 APTX; aprataxin [EC:3.6.1.70 3.6.1.71 3.6.1.72]
E 113211713 aprataxin and PNK-like factor K13295 APLF; aprataxin and PNK-like factor [EC:3.1.-.-]
E 113210076 uncharacterized protein F21D5.5 K08073 PNKP; bifunctional polynucleotide phosphatase/kinase [EC:3.1.3.32 2.7.1.78]
E 113206251 high mobility group-T protein isoform X1 K10802 HMGB1; high mobility group protein B1
E 113209296 DNA polymerase lambda-like isoform X1 K03512 POLL; DNA polymerase lambda [EC:2.7.7.7 4.2.99.-]
E 113202029 poly [ADP-ribose] polymerase K24070 PARP1; poly [ADP-ribose] polymerase 1 [EC:2.4.2.30]
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E XPC-HR23B-CETN2 complex
F 113213985 LOW QUALITY PROTEIN: DNA repair protein complementing XP-C cells homolog K10838 XPC; xeroderma pigmentosum group C-complementing protein
F 113210493 UV excision repair protein RAD23 homolog B isoform X1 K10839 RAD23; UV excision repair protein RAD23
E Cul4-DDB2 complex
F 113211873 RING-box protein 1A K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
F 113209010 cullin-4A K10609 CUL4; cullin 4
F 113203498 DNA damage-binding protein 1 K10610 DDB1; DNA damage-binding protein 1
E NER4 complex
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase II complex
F 113209466 DNA-directed RNA polymerase II subunit RPB1 K03006 RPB1; DNA-directed RNA polymerase II subunit RPB1 [EC:2.7.7.6]
F 113212527 DNA-directed RNA polymerase II subunit RPB1-like K03006 RPB1; DNA-directed RNA polymerase II subunit RPB1 [EC:2.7.7.6]
F 113208949 DNA-directed RNA polymerase II subunit RPB2 K03010 RPB2; DNA-directed RNA polymerase II subunit RPB2 [EC:2.7.7.6]
F 113217368 DNA-directed RNA polymerase II subunit RPB3 K03011 RPB3; DNA-directed RNA polymerase II subunit RPB3
F 113217903 DNA-directed RNA polymerases I, II, and III subunit RPABC1 K03013 RPABC1; DNA-directed RNA polymerases I, II, and III subunit RPABC1
F 113209524 DNA-directed RNA polymerases I, II, and III subunit RPABC1 isoform X1 K03013 RPABC1; DNA-directed RNA polymerases I, II, and III subunit RPABC1
F 113210741 DNA-directed RNA polymerases I, II, and III subunit RPABC2 K03014 RPABC2; DNA-directed RNA polymerases I, II, and III subunit RPABC2
F 113203941 DNA-directed RNA polymerase II subunit RPB7 K03015 RPB7; DNA-directed RNA polymerase II subunit RPB7
F 113202379 DNA-directed RNA polymerases I, II, and III subunit RPABC3 isoform X1 K03016 RPABC3; DNA-directed RNA polymerases I, II, and III subunit RPABC3
F 113205162 DNA-directed RNA polymerase II subunit RPB9 K03017 RPB9; DNA-directed RNA polymerase II subunit RPB9
F 113203408 DNA-directed RNA polymerases I, II, and III subunit RPABC5 K03007 RPABC5; DNA-directed RNA polymerases I, II, and III subunit RPABC5
F 113205015 DNA-directed RNA polymerase II subunit RPB11 K03008 RPB11; DNA-directed RNA polymerase II subunit RPB11
F 113210662 DNA-directed RNA polymerases I, II, and III subunit RPABC4 K03009 RPABC4; DNA-directed RNA polymerases I, II, and III subunit RPABC4
E Cul4-CSA complex
F 113211873 RING-box protein 1A K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
F 113209010 cullin-4A K10609 CUL4; cullin 4
F 113203498 DNA damage-binding protein 1 K10610 DDB1; DNA damage-binding protein 1
F 113204678 DNA excision repair protein ERCC-8 K10570 ERCC8; DNA excision repair protein ERCC-8
E Other TCR factor
F 113202063 DNA excision repair protein ERCC-6-like K10841 ERCC6; DNA excision repair protein ERCC-6
F 113212566 UV-stimulated scaffold protein A K23720 UVSSA; UV-stimulated scaffold protein A
D TFIIH complex
E 113208879 general transcription and DNA repair factor IIH helicase subunit XPB K10843 ERCC3; DNA excision repair protein ERCC-3 [EC:5.6.2.4]
E 113216015 general transcription and DNA repair factor IIH helicase subunit XPD K10844 ERCC2; DNA excision repair protein ERCC-2 [EC:5.6.2.3]
E 113216033 general transcription factor IIH subunit 1 isoform X1 K03141 TFIIH1; transcription initiation factor TFIIH subunit 1
E 113216364 general transcription factor IIH subunit 2 K03142 TFIIH2; transcription initiation factor TFIIH subunit 2
E 113207330 general transcription factor IIH subunit 3 K03143 TFIIH3; transcription initiation factor TFIIH subunit 3
E 113202652 general transcription factor IIH subunit 4 K03144 TFIIH4; transcription initiation factor TFIIH subunit 4
E 113217567 general transcription factor IIH subunit 5 K10845 TTDA; TFIIH basal transcription factor complex TTD-A subunit
E 113218402 cyclin-dependent kinase 7 K02202 CDK7; cyclin-dependent kinase 7 [EC:2.7.11.22 2.7.11.23]
E 113216096 cyclin-H K06634 CCNH; cyclin H
E 113204704 CDK-activating kinase assembly factor MAT1 K10842 MNAT1; CDK-activating kinase assembly factor MAT1
D RPA (replication factor A)
E 113213857 replication protein A 70 kDa DNA-binding subunit K07466 RFA1; replication factor A1
E 113209768 replication protein A 32 kDa subunit K10739 RFA2; replication factor A2
E 113208844 uncharacterized protein LOC113208844 K10740 RPA3; replication factor A3
D Other NER factors
E 113202167 DNA repair protein complementing XP-A cells homolog K10847 XPA; DNA-repair protein complementing XP-A cells
E 113211893 DNA excision repair protein ERCC-1 K10849 ERCC1; DNA excision repair protein ERCC-1
E 113206243 DNA repair endonuclease XPF K10848 ERCC4; DNA excision repair protein ERCC-4 [EC:3.1.-.-]
E 113204059 DNA excision repair protein ERCC-5 homolog K10846 ERCC5; DNA excision repair protein ERCC-5
E 113216090 DNA ligase 1 isoform X1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
E 113210131 MMS19 nucleotide excision repair protein K15075 MET18; DNA repair/transcription protein MET18/MMS19
E 113217497 cullin-3 K03869 CUL3; cullin 3
E 113203886 cullin-5 isoform X1 K10612 CUL5; cullin 5
E 113211360 elongin-B K03873 ELOB; elongin-B
E 113208003 transcription elongation factor B polypeptide 3 K15076 ELOA; elongin-A
E 113206637 protein lingerer isoform X1 K26545 UBAP2; ubiquitin-associated protein 2
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
E 113213993 DNA mismatch repair protein Msh2 K08735 MSH2; DNA mismatch repair protein MSH2
E 113214568 DNA mismatch repair protein Msh3 K08736 MSH3; DNA mismatch repair protein MSH3
E 113207724 DNA mismatch repair protein Msh6 K08737 MSH6; DNA mismatch repair protein MSH6
D MutL homologs
E 113213771 PMS1 protein homolog 1-like K10864 PMS1; DNA mismatch repair protein PMS1
E 113210841 DNA mismatch repair protein Mlh1 K08734 MLH1; DNA mismatch repair protein MLH1
E 113202772 mismatch repair endonuclease PMS2 K10858 PMS2; DNA mismatch repair protein PMS2
E 113214047 DNA mismatch repair protein Mlh3-like isoform X1 K08739 MLH3; DNA mismatch repair protein MLH3
D DNA polymerase delta complex
E 113213059 DNA polymerase delta catalytic subunit isoform X1 K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
E 113210025 DNA polymerase delta subunit 2 K02328 POLD2; DNA polymerase delta subunit 2
E 113207544 DNA polymerase delta subunit 3 K03504 POLD3; DNA polymerase delta subunit 3
D RPA (replication factor A)
E 113213857 replication protein A 70 kDa DNA-binding subunit K07466 RFA1; replication factor A1
E 113209768 replication protein A 32 kDa subunit K10739 RFA2; replication factor A2
E 113208844 uncharacterized protein LOC113208844 K10740 RPA3; replication factor A3
D RFC (replication factor C)
E 113213690 replication factor C subunit 1 K10754 RFC1; replication factor C subunit 1
E 113208495 replication factor C subunit 4 K10755 RFC2_4; replication factor C subunit 2/4
E 113211828 replication factor C subunit 2 K10755 RFC2_4; replication factor C subunit 2/4
E 113205945 replication factor C subunit 5 K10756 RFC3_5; replication factor C subunit 3/5
E 113210716 replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
D Other MMR factors
E 113203395 proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
E 113207180 exonuclease 1 K10746 EXO1; exonuclease 1 [EC:3.1.-.-]
E 113206251 high mobility group-T protein isoform X1 K10802 HMGB1; high mobility group protein B1
E 113216090 DNA ligase 1 isoform X1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
E 113201707 WD repeat-containing protein 76-like K24755 WDR76; WD repeat-containing protein 76
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D MRN(MRX) complex
E 113205273 double-strand break repair protein MRE11 K10865 MRE11; double-strand break repair protein MRE11
E 113211160 DNA repair protein RAD50 isoform X1 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
E 113207005 nibrin isoform X1 K10867 NBN; nibrin
D BRCA1-core complex
E 113212331 BRCA1-associated RING domain protein 1-like K10683 BARD1; BRCA1-associated RING domain protein 1
D BRCA1-A complex
E 113206290 uncharacterized protein LOC113206290 K20776 BABAM; BRISC and BRCA1-A complex member 1
E 113202310 BRISC and BRCA1-A complex member 2 K12173 BRE; BRCA1-A complex subunit BRE
E 113204363 lys-63-specific deubiquitinase BRCC36 K11864 BRCC3; BRCA1/BRCA2-containing complex subunit 3 [EC:3.4.19.-]
D BRCA1-B complex
E 113203719 DNA topoisomerase 2-binding protein 1 isoform X2 K10728 TOPBP1; topoisomerase (DNA) II binding protein 1
D BRCA1-C complex
E 113208748 uncharacterized protein LOC113208748 isoform X1 K20773 RBBP8; DNA endonuclease RBBP8 [EC:3.1.-.-]
E 113205273 double-strand break repair protein MRE11 K10865 MRE11; double-strand break repair protein MRE11
E 113211160 DNA repair protein RAD50 isoform X1 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
E 113207005 nibrin isoform X1 K10867 NBN; nibrin
D BRCA complex
E 113210742 breast cancer type 2 susceptibility protein homolog isoform X2 K08775 BRCA2; breast cancer 2 susceptibility protein
E 113216685 DNA repair protein RAD51 homolog 1 K04482 RAD51; DNA repair protein RAD51
D RecA family proteins
E 113216685 DNA repair protein RAD51 homolog 1 K04482 RAD51; DNA repair protein RAD51
E 113213342 DNA repair protein RAD51 homolog 3 K10870 RAD51L2; RAD51-like protein 2
E 113217650 DNA repair protein RAD51 homolog 4 K10871 RAD51L3; RAD51-like protein 3
E 113215626 DNA repair protein XRCC2 isoform X1 K10879 XRCC2; DNA-repair protein XRCC2
E 113212354 DNA repair protein XRCC3 isoform X1 K10880 XRCC3; DNA-repair protein XRCC3
D Rad52 family proteins
E 113217819 DNA repair protein RAD52 homolog K10873 RAD52; DNA repair and recombination protein RAD52
D Rad54 family proteins
E 113210304 DNA repair and recombination protein RAD54-like K10875 RAD54L; DNA repair and recombination protein RAD54 and RAD54-like protein [EC:5.6.2.-]
E 113207617 uncharacterized protein LOC113207617 K10876 RAD54L2; RAD54-like protein 2 [EC:5.6.2.-]
E 113205152 DNA repair and recombination protein RAD54B-like K10877 RAD54B; DNA repair and recombination protein RAD54B [EC:5.6.2.-]
D RecQ family DNA helicases
E 113213265 ATP-dependent DNA helicase Q1-like K10899 RECQL; ATP-dependent DNA helicase Q1 [EC:5.6.2.4]
E 113213070 bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN K10900 WRN; werner syndrome ATP-dependent helicase [EC:5.6.2.4]
E 113215504 recQ-like DNA helicase Blm K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 113202314 recQ-like DNA helicase Blm isoform X1 K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 113211777 recQ-like DNA helicase Blm K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 113212805 ATP-dependent DNA helicase Q4 K10730 RECQL4; ATP-dependent DNA helicase Q4 [EC:5.6.2.4]
D Bloom's syndrome complex (BTR)
E 113215504 recQ-like DNA helicase Blm K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 113202314 recQ-like DNA helicase Blm isoform X1 K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 113211777 recQ-like DNA helicase Blm K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 113214879 DNA topoisomerase 3-alpha-like isoform X1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 113211778 LOW QUALITY PROTEIN: DNA topoisomerase 3-alpha-like K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 113204217 DNA topoisomerase 3-beta-1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 113211307 recQ-mediated genome instability protein 1 K10990 RMI1; RecQ-mediated genome instability protein 1
E 113214071 uncharacterized protein LOC113214071 K15365 RMI2; RecQ-mediated genome instability protein 2
D RPA (replication factor A)
E 113213857 replication protein A 70 kDa DNA-binding subunit K07466 RFA1; replication factor A1
E 113209768 replication protein A 32 kDa subunit K10739 RFA2; replication factor A2
E 113208844 uncharacterized protein LOC113208844 K10740 RPA3; replication factor A3
D Protein phosphatase 4
E 113214224 serine/threonine-protein phosphatase 4 catalytic subunit isoform X1 K15423 PPP4C; serine/threonine-protein phosphatase 4 catalytic subunit [EC:3.1.3.16]
E 113203049 serine/threonine-protein phosphatase 4 regulatory subunit 1 K15424 PPP4R1; serine/threonine-protein phosphatase 4 regulatory subunit 1
E 113201839 serine/threonine-protein phosphatase 4 regulatory subunit 2 K15425 PPP4R2; serine/threonine-protein phosphatase 4 regulatory subunit 2
E 113207376 serine/threonine-protein phosphatase 4 regulatory subunit 3 K17491 SMEK; protein phosphatase 4 regulatory subunit 3
E 113217773 serine/threonine-protein phosphatase 4 regulatory subunit 4 isoform X1 K15426 PPP4R4; serine/threonine-protein phosphatase 4 regulatory subunit 4
D AP-5 complex
D SMC5-SMC6 complex
E 113201737 structural maintenance of chromosomes protein 5 isoform X2 K22803 SMC5; structural maintenance of chromosomes protein 5
E 113214232 structural maintenance of chromosomes protein 6-like isoform X1 K22804 SMC6; structural maintenance of chromosomes protein 6
E 113201899 structural maintenance of chromosomes protein 6 K22804 SMC6; structural maintenance of chromosomes protein 6
E 113211875 structural maintenance of chromosomes protein 6-like K22804 SMC6; structural maintenance of chromosomes protein 6
E 113202157 uncharacterized protein LOC113202157 K22817 NSMCE1; non-structural maintenance of chromosomes element 1 [EC:2.3.2.27]
E 113202655 melanoma-associated antigen D2 K22823 NSMCE3; non-structural maintenance of chromosomes element 3
E 113204290 non-structural maintenance of chromosomes element 4 homolog A K22825 NSMCE4; non-structural maintenance of chromosomes element 4
D Other HR factors
E 113202373 crossover junction endonuclease EME1 isoform X2 K10882 EME1; crossover junction endonuclease EME1 [EC:3.1.22.-]
E 113214572 exonuclease 3'-5' domain-containing protein 2 K20777 EXD2; exonuclease 3'-5' domain-containing protein 2 [EC:3.1.11.1]
E 113206441 crossover junction endonuclease MUS81 K08991 MUS81; crossover junction endonuclease MUS81 [EC:3.1.22.-]
E 113204640 26S proteasome complex subunit SEM1 K10881 SHFM1; 26 proteasome complex subunit DSS1
E 113210929 structure-specific endonuclease subunit slx1 K15078 SLX1; structure-specific endonuclease subunit SLX1 [EC:3.6.1.-]
E 113203043 flap endonuclease GEN K15338 GEN1; holliday junction resolvase GEN1/YEN1 [EC:3.1.-.-]
E 113203991 zinc finger FYVE domain-containing protein 26 K19027 ZFYVE26; zinc finger FYVE domain-containing protein 26
E 113208951 mortality factor 4-like protein 1 K11339 MORF4L1; mortality factor 4-like protein 1
E 113209954 deoxynucleoside triphosphate triphosphohydrolase SAMHD1-like isoform X1 K22544 SAMHD1; deoxynucleoside triphosphate triphosphohydrolase SAMHD1 [EC:3.1.5.-]
E 113203482 deoxynucleoside triphosphate triphosphohydrolase SAMHD1-like isoform X1 K22544 SAMHD1; deoxynucleoside triphosphate triphosphohydrolase SAMHD1 [EC:3.1.5.-]
E 113206444 fidgetin-like protein 1 K22766 FIGNL1; fidgetin-like protein 1 [EC:5.6.2.-]
E 113215849 fidgetin-like protein 1 K22766 FIGNL1; fidgetin-like protein 1 [EC:5.6.2.-]
E 113215913 fidgetin-like protein 1 K22766 FIGNL1; fidgetin-like protein 1 [EC:5.6.2.-]
E 113202106 uncharacterized protein LOC113202106 isoform X4 K23112 BRAT1; BRCA1-associated ATM activator 1
E 113209020 trithorax group protein osa isoform X1 K23456 CFAP410; cilla- and flagella-associated protein
E 113209778 zinc finger SWIM domain-containing protein 7 K25770 ZSWIM7; zinc finger SWIM domain-containing protein 7
E 113206877 BRCA2-interacting transcriptional repressor EMSY isoform X1 K25790 EMSY; BRCA2-interacting transcriptional repressor EMSY
E 113207522 heat shock factor 2-binding protein-like K25791 HSF2BP; heat shock factor 2-binding protein
E 113211867 protein MMS22-like K26125 MMS22L; protein MMS22-like
E 113203002 tonsoku-like protein K09257 NFKBIL2; NF-kappa-B inhibitor-like protein 2
C NHEJ (non-homologous end-joining)
D DNA-PK complex
E 113206540 X-ray repair cross-complementing protein 6 isoform X1 K10884 XRCC6; ATP-dependent DNA helicase 2 subunit 1
E 113208799 X-ray repair cross-complementing protein 5 K10885 XRCC5; ATP-dependent DNA helicase 2 subunit 2
E 113205299 DNA-dependent protein kinase catalytic subunit isoform X1 K06642 PRKDC; DNA-dependent protein kinase catalytic subunit [EC:2.7.11.1]
D MRX complex
E 113205273 double-strand break repair protein MRE11 K10865 MRE11; double-strand break repair protein MRE11
E 113211160 DNA repair protein RAD50 isoform X1 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
D DNA Ligase 4 complex
E 113217533 DNA ligase 4 K10777 LIG4; DNA ligase 4 [EC:6.5.1.1]
E 113217716 uncharacterized protein LOC113217716 isoform X1 K10886 XRCC4; DNA-repair protein XRCC4
D X-family DNA polymerases
E 113209296 DNA polymerase lambda-like isoform X1 K03512 POLL; DNA polymerase lambda [EC:2.7.7.7 4.2.99.-]
E 113203287 DNA polymerase beta K02330 POLB; DNA polymerase beta [EC:2.7.7.7 4.2.99.-]
D Other NHEJ factors
E 113204005 aprataxin K10863 APTX; aprataxin [EC:3.6.1.70 3.6.1.71 3.6.1.72]
E 113211713 aprataxin and PNK-like factor K13295 APLF; aprataxin and PNK-like factor [EC:3.1.-.-]
E 113209725 protein artemis-like K10887 DCLRE1C; DNA cross-link repair 1C protein [EC:3.1.-.-]
E 113204604 tyrosyl-DNA phosphodiesterase 2-like isoform X2 K19619 TDP2; tyrosyl-DNA phosphodiesterase 2 [EC:3.1.4.-]
C FA (Fanconi anemia) pathway
D FA core complex
E 113206708 E3 ubiquitin-protein ligase FANCL K10606 FANCL; E3 ubiquitin-protein ligase FANCL [EC:2.3.2.27]
E 113207503 uncharacterized protein LOC113207503 isoform X1 K10896 FANCM; fanconi anemia group M protein
E 113217868 Fanconi anemia core complex-associated protein 24-like K10898 FAAP24; fanconi anemia-associated protein
D FA core complex binding factors
E 113205723 centromere protein S-like K11511 APITD1; centromere protein S
E 113207287 centromere protein X-like K15360 STRA13; centromere protein X
E 113208774 ubiquitin-conjugating enzyme E2 D4-like K13960 UBE2T; ubiquitin-conjugating enzyme E2 T [EC:2.3.2.23]
D Bloom's syndrome complex (BTR)
E 113215504 recQ-like DNA helicase Blm K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 113202314 recQ-like DNA helicase Blm isoform X1 K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 113211777 recQ-like DNA helicase Blm K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 113214879 DNA topoisomerase 3-alpha-like isoform X1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 113211778 LOW QUALITY PROTEIN: DNA topoisomerase 3-alpha-like K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 113204217 DNA topoisomerase 3-beta-1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 113211307 recQ-mediated genome instability protein 1 K10990 RMI1; RecQ-mediated genome instability protein 1
E 113214071 uncharacterized protein LOC113214071 K15365 RMI2; RecQ-mediated genome instability protein 2
D FANCD2-I complex
E 113208769 Fanconi anemia group D2 protein K10891 FANCD2; fanconi anemia group D2 protein
E 113214549 Fanconi anemia group I protein K10895 FANCI; fanconi anemia group I protein
D Downstream FA components
E 113210742 breast cancer type 2 susceptibility protein homolog isoform X2 K08775 BRCA2; breast cancer 2 susceptibility protein
D Other FA pathway factors
E 113206173 fanconi-associated nuclease 1-like K15363 FAN1; fanconi-associated nuclease 1 [EC:3.1.21.- 3.1.4.1]
E 113216685 DNA repair protein RAD51 homolog 1 K04482 RAD51; DNA repair protein RAD51
E 113213342 DNA repair protein RAD51 homolog 3 K10870 RAD51L2; RAD51-like protein 2
E 113218070 ubiquitin carboxyl-terminal hydrolase 1 isoform X3 K11832 USP1; ubiquitin carboxyl-terminal hydrolase 1 [EC:3.4.19.12]
E 113202269 WD repeat-containing protein 48 K15361 WDR48; WD repeat-containing protein 48
C Other DSBR factors
D Protein phosphatase 6
E 113205134 serine/threonine-protein phosphatase 6 catalytic subunit K15498 PPP6C; serine/threonine-protein phosphatase 6 catalytic subunit [EC:3.1.3.16]
E 113209936 serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X1 K15501 PPP6R3; serine/threonine-protein phosphatase 6 regulatory subunit 3
E 113217479 serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A isoform X1 K15502 ANKRD28; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A
D Ubiquitin ligases
E 113204220 ras guanine nucleotide exchange factor R-like isoform X1 K10667 RNF8; E3 ubiquitin-protein ligase RNF8 [EC:2.3.2.27]
E 113215672 E3 ubiquitin-protein ligase rnf168 K20779 RNF168; E3 ubiquitin-protein ligase RNF168 [EC:2.3.2.31]
E 113205593 E3 ubiquitin-protein ligase HERC2 K10595 HERC2; E3 ubiquitin-protein ligase HERC2 [EC:2.3.2.26]
D Others
E 113210833 telomerase Cajal body protein 1 isoform X1 K23314 WRAP53; telomerase Cajal body protein 1
E 113201937 uncharacterized protein LOC113201937 K24688 ZCWPW1; zinc finger CW-type PWWP domain protein 1
E 113213108 gastrulation defective protein 1 homolog K24752 WDR70; WD repeat-containing protein 70
E 113201707 WD repeat-containing protein 76-like K24755 WDR76; WD repeat-containing protein 76
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
D 113216118 DNA polymerase eta K03509 POLH; DNA polymerase eta [EC:2.7.7.7]
D 113213815 DNA polymerase iota K03510 POLI; DNA polymerase iota [EC:2.7.7.7]
D 113207987 DNA repair protein REV1 K03515 REV1; DNA repair protein REV1 [EC:2.7.7.-]
C B-family DNA polymerases
D 113204847 DNA polymerase zeta catalytic subunit isoform X1 K02350 REV3L; DNA polymerase zeta [EC:2.7.7.7]
C A-family DNA polymerase
C Rad6 epistasis group
D 113206419 ubiquitin-conjugating enzyme E2 A isoform X1 K10573 UBE2A; ubiquitin-conjugating enzyme E2 A [EC:2.3.2.23]
D 113214733 E3 ubiquitin-protein ligase RAD18-like K10627 RAD18; E3 ubiquitin-protein ligase RAD18 [EC:2.3.2.27]
D 113212371 ubiquitin-conjugating enzyme E2 variant 2 K10704 UBE2V; ubiquitin-conjugating enzyme E2 variant
D 113203156 ubiquitin-conjugating enzyme E2 N K10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23]
C Other TLS factors
D 113203395 proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
D 113207831 DNA-dependent metalloprotease SPRTN-like K24051 SPRTN; SprT-like domain-contaning protein Spartan
D 113202813 DNA-dependent metalloprotease dvc-1-like isoform X1 K24051 SPRTN; SprT-like domain-contaning protein Spartan
D 113207648 germ cell nuclear acidic protein-like isoform X3 K26957 GCNA; germ cell nuclear acidic protein
B Check point factors
C Rad9-Hus1-Rad1 complex
D 113202052 cell cycle checkpoint control protein RAD9A K10994 RAD9A; cell cycle checkpoint control protein RAD9A [EC:3.1.11.2]
D 113206512 checkpoint protein HUS1 K10903 HUS1; HUS1 checkpoint protein
D 113207345 cell cycle checkpoint protein RAD1 K02830 HRAD1; cell cycle checkpoint protein [EC:3.1.11.2]
C HRAD17(Rad24)-RFC complex
D 113208794 cell cycle checkpoint protein RAD17 K06662 HRAD17; cell cycle checkpoint protein
D 113208495 replication factor C subunit 4 K10755 RFC2_4; replication factor C subunit 2/4
D 113211828 replication factor C subunit 2 K10755 RFC2_4; replication factor C subunit 2/4
D 113205945 replication factor C subunit 5 K10756 RFC3_5; replication factor C subunit 3/5
D 113210716 replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
C Rad17-Mec3-Ddc1 complex
D 113207345 cell cycle checkpoint protein RAD1 K02830 HRAD1; cell cycle checkpoint protein [EC:3.1.11.2]
C FPC (fork protection complex)
D 113202243 MICAL-like protein 1 K10998 TIPIN; replication fork protection complex subunit TIPIN/Csm3/Swi3
D 113210660 claspin isoform X2 K25773 CLSPN; claspin
C Triple T complex
D 113217925 TELO2-interacting protein 1 homolog isoform X1 K20403 TTI1; TELO2-interacting protein 1
D 113209309 TELO2-interacting protein 2-like K23115 TTI2; TELO2-interacting protein 2
C BAG6-UBL4A-GET4 complex
D 113206199 large proline-rich protein bag6-A isoform X1 K23390 BAG6; large proline-rich protein BAG6
D 113201746 ubiquitin-like protein 4A K23388 UBL4; ubiquitin-like protein 4
D 113205373 Golgi to ER traffic protein 4 homolog K23387 GET4; golgi to ER traffic protein 4
C Other check point factors
D 113205426 serine/threonine-protein kinase ATR-like K06640 ATR; serine/threonine-protein kinase ATR [EC:2.7.11.1]
D 113218424 serine-protein kinase ATM K04728 ATM; serine-protein kinase ATM [EC:2.7.11.1]
D 113211063 cellular tumor antigen p53 K04451 TP53; tumor protein p53
D 113212481 serine/threonine-protein kinase grp K02216 CHEK1; serine/threonine-protein kinase CHEK1 [EC:2.7.11.1]
D 113217272 ovarian-specific serine/threonine-protein kinase Lok K06641 CHEK2; serine/threonine-protein kinase CHEK2 [EC:2.7.11.1]
D 113202880 ovarian-specific serine/threonine-protein kinase Lok-like K06641 CHEK2; serine/threonine-protein kinase CHEK2 [EC:2.7.11.1]
D 113211357 ovarian-specific serine/threonine-protein kinase Lok-like K06641 CHEK2; serine/threonine-protein kinase CHEK2 [EC:2.7.11.1]
D 113205124 M-phase inducer phosphatase isoform X1 K05866 CDC25B; M-phase inducer phosphatase 2 [EC:3.1.3.48]
D 113202324 14-3-3 protein zeta isoform X1 K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
D 113210698 14-3-3 protein epsilon isoform X1 K06630 YWHAE; 14-3-3 protein epsilon
D 113206424 protein sickie K19483 NAV2; neuron navigator 2 [EC:5.6.2.4]
D 113208531 wee1-like protein kinase K06632 WEE1; wee1-like protein kinase [EC:2.7.11.1]
D 113206270 period circadian protein isoform X3 K02633 PER2; period circadian protein 2
D 113210506 mediator of DNA damage checkpoint protein 1 K20780 MDC1; mediator of DNA damage checkpoint protein 1
D 113212042 plastin-2 K17336 PLS3; plastin-3
D 113206349 protein downstream neighbor of son homolog isoform X1 K22422 DONSON; protein downstream neighbor of Son
D 113206963 KN motif and ankyrin repeat domain-containing protein 2 K22808 KANK; KN motif and ankyrin repeat domain-containing protein
D 113213822 vacuolar protein sorting-associated protein 4 K12196 VPS4; vacuolar protein-sorting-associated protein 4
D 113204233 uncharacterized protein LOC113204233 K12196 VPS4; vacuolar protein-sorting-associated protein 4
D 113203054 abscission/NoCut checkpoint regulator K24778 ZFYVE19; abscission/NoCut checkpoint regulator
D 113212927 replication stress response regulator SDE2 K25059 SDE2; replication stress response regulator SDE2
B Other factors with a suspected DNA repair function
C DNA polymerases
D 113217551 DNA polymerase theta K02349 POLQ; DNA polymerase theta [EC:2.7.7.7]
D 113207111 myb-binding protein 1A K02331 POL5; DNA polymerase phi [EC:2.7.7.7]
D 113212647 DNA-directed primase/polymerase protein-like K22761 PRIMPOL; DNA-directed primase/polymerase protein [EC:2.7.7.102 2.7.7.7]
C Nucleases
D 113203556 uncharacterized protein LOC113203556 K10791 TREX2; three prime repair exonuclease 2 [EC:3.1.11.2]
D 113203271 DNA cross-link repair 1A protein-like K15340 DCLRE1A; DNA cross-link repair 1A protein
D 113205739 ankyrin repeat and LEM domain-containing protein 1 K21411 ANKLE1; ankyrin repeat and LEM domain-containing protein 1
C Helicases
D 113203737 helicase POLQ-like isoform X1 K19178 HELQ; POLQ-like helicase [EC:5.6.2.4]
D 113204173 DNA excision repair protein ERCC-6-like 2 isoform X1 K20098 ERCC6L2; DNA excision repair protein ERCC-6-like 2 [EC:5.6.2.-]
C PSO4 complex
D 113201788 pre-mRNA-processing factor 19 K10599 PRPF19; pre-mRNA-processing factor 19 [EC:2.3.2.27]
D 113204048 cell division cycle 5-like protein K12860 CDC5L; pre-mRNA-splicing factor CDC5/CEF1
D 113209923 pre-mRNA-splicing factor SPF27 K12861 BCAS2; pre-mRNA-splicing factor SPF27
D 113210491 pleiotropic regulator 1 K12862 PLRG1; pleiotropic regulator 1
C Modulation of nucleotide pools
D 113204888 oxidized purine nucleoside triphosphate hydrolase-like K17816 NUDT1; 8-oxo-dGTP diphosphatase / 2-hydroxy-dATP diphosphatase [EC:3.6.1.55 3.6.1.56]
D 113204597 8-oxo-dGDP phosphatase NUDT18 K17817 NUDT18; 8-oxo-dGDP phosphatase [EC:3.6.1.58]
D 113206914 deoxyuridine 5'-triphosphate nucleotidohydrolase K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 113213618 ribonucleoside-diphosphate reductase large subunit K10807 RRM1; ribonucleoside-diphosphate reductase subunit M1 [EC:1.17.4.1]
#
AProkaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D 113203291 methylated-DNA--protein-cysteine methyltransferase K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
D 113204870 deoxyribodipyrimidine photo-lyase-like K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]
C BER (base exicision repair)
D DNA glycosylases
E 113203580 uracil-DNA glycosylase-like K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E 113211036 single-strand selective monofunctional uracil DNA glycosylase-like isoform X1 K10800 SMUG1; single-strand selective monofunctional uracil DNA glycosylase [EC:3.2.2.-]
E 113208876 DNA-3-methyladenine glycosylase K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]
E 113209396 adenine DNA glycosylase-like K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
D AP endonucleases
D RecJ
D DNA ligase
D DNA polymerase I
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase complex (RNAP)
E TRCF (transcription-repair coupling factor)
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
D Molecular matchmaker
D Strand discrimination factor
D DNA exonucleases
D DNA polymerase III holoenzyme
D DNA ligase
D Other MMR factors
E 113208052 single-stranded DNA-binding protein, mitochondrial K03111 ssb; single-strand DNA-binding protein
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D RecBC pathway proteins
D RecFOR pathway proteins
D AddAB pathway proteins
D Other HR factor
D Archaeal homologous recombinant proteins
C NHEJ (non-homologous end-joining)
D Two-component NHEJ DNA repair complex
D SHIIR (short-homology-independent illegitimate recombination)
E Facilitator
E Supressor
D SHDIR (short-homology-dependent illegitimate recombination)
E RecET pathway
E Facilitator
E Supressor
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
C Other SOS response factors
D 113208052 single-stranded DNA-binding protein, mitochondrial K03111 ssb; single-strand DNA-binding protein
B Other factors with a suspected DNA repair function
C DNA polymerase
C DNA helicases
C Modulation of nucleotide pools
D 113206914 deoxyuridine 5'-triphosphate nucleotidohydrolase K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
C Others
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#
#[ BRITE | KEGG2 | KEGG ]
#Last updated: March 29, 2024