+F Repair protein KO
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DNA Repair and Recombination Proteins - Frieseomelitta varia
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AEukaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D 122534123 activating signal cointegrator 1 complex subunit 3 K18663 ASCC3; activating signal cointegrator complex subunit 3 [EC:5.6.2.4]
D 122533088 deoxyribodipyrimidine photo-lyase isoform X1 K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]
C BER (base exicision repair)
D DNA glycosylases
E 122530665 G/T mismatch-specific thymine DNA glycosylase-like K20813 TDG; thymine-DNA glycosylase [EC:3.2.2.29]
E 122530238 atrophin-1-like K20813 TDG; thymine-DNA glycosylase [EC:3.2.2.29]
E 122537603 putative 3-methyladenine DNA glycosylase K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]
E 122528337 single-strand selective monofunctional uracil DNA glycosylase isoform X1 K10800 SMUG1; single-strand selective monofunctional uracil DNA glycosylase [EC:3.2.2.-]
E 122530411 N-glycosylase/DNA lyase K03660 OGG1; N-glycosylase/DNA lyase [EC:3.2.2.- 4.2.99.18]
E 122536248 endonuclease III-like protein 1 isoform X1 K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
E 122536969 DNA-(apurinic or apyrimidinic site) endonuclease isoform X1 K10771 APEX1; AP endonuclease 1 [EC:3.1.11.2]
D Long Patch-BER factors
E DNA polymerase delta complex
F 122532701 DNA polymerase delta catalytic subunit isoform X1 K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
F 122535658 DNA polymerase delta subunit 2-like isoform X1 K02328 POLD2; DNA polymerase delta subunit 2
F 122527240 DNA polymerase delta subunit 2-like K02328 POLD2; DNA polymerase delta subunit 2
E DNA polymerase epsilon complex
F 122531439 DNA polymerase epsilon catalytic subunit 1 K02324 POLE; DNA polymerase epsilon subunit 1 [EC:2.7.7.7]
F 122536648 DNA polymerase epsilon subunit 2 isoform X1 K02325 POLE2; DNA polymerase epsilon subunit 2 [EC:2.7.7.7]
F 122533482 DNA polymerase epsilon subunit 3 K02326 POLE3; DNA polymerase epsilon subunit 3 [EC:2.7.7.7]
F 122527306 DNA polymerase epsilon subunit 4 K03506 POLE4; DNA polymerase epsilon subunit 4 [EC:2.7.7.7]
E 122538843 proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
E 122526941 flap endonuclease 1 K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
E 122530880 DNA ligase 1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
D Short Patch-BER factors
E 122533770 DNA polymerase beta-like K02330 POLB; DNA polymerase beta [EC:2.7.7.7 4.2.99.-]
E 122532738 DNA repair protein XRCC1 isoform X1 K10803 XRCC1; DNA-repair protein XRCC1
E 122530712 DNA ligase 3 K10776 LIG3; DNA ligase 3 [EC:6.5.1.1]
D Other BER factors
E 122538126 probable tyrosyl-DNA phosphodiesterase isoform X1 K10862 TDP1; tyrosyl-DNA phosphodiesterase 1 [EC:3.1.4.-]
E 122535622 aprataxin K10863 APTX; aprataxin [EC:3.6.1.70 3.6.1.71 3.6.1.72]
E 122529067 aprataxin and PNK-like factor isoform X1 K13295 APLF; aprataxin and PNK-like factor [EC:3.1.-.-]
E 122530728 uncharacterized protein F21D5.5 K08073 PNKP; bifunctional polynucleotide phosphatase/kinase [EC:3.1.3.32 2.7.1.78]
E 122527270 high mobility group protein DSP1-like K10802 HMGB1; high mobility group protein B1
E 122535846 poly [ADP-ribose] polymerase K24070 PARP1; poly [ADP-ribose] polymerase 1 [EC:2.4.2.30]
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E XPC-HR23B-CETN2 complex
F 122537937 DNA repair protein complementing XP-C cells homolog K10838 XPC; xeroderma pigmentosum group C-complementing protein
F 122527594 UV excision repair protein RAD23 homolog B isoform X1 K10839 RAD23; UV excision repair protein RAD23
E Cul4-DDB2 complex
F 122537109 RING-box protein 1A K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
F 122531513 cullin-4A isoform X1 K10609 CUL4; cullin 4
F 122529633 DNA damage-binding protein 1 K10610 DDB1; DNA damage-binding protein 1
E NER4 complex
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase II complex
F 122534330 DNA-directed RNA polymerase II subunit RPB1 isoform X1 K03006 RPB1; DNA-directed RNA polymerase II subunit RPB1 [EC:2.7.7.6]
F 122529749 LOW QUALITY PROTEIN: DNA-directed RNA polymerase II subunit RPB2 K03010 RPB2; DNA-directed RNA polymerase II subunit RPB2 [EC:2.7.7.6]
F 122528243 DNA-directed RNA polymerase II subunit RPB3 K03011 RPB3; DNA-directed RNA polymerase II subunit RPB3
F 122531598 DNA-directed RNA polymerases I, II, and III subunit RPABC1 K03013 RPABC1; DNA-directed RNA polymerases I, II, and III subunit RPABC1
F 122536493 DNA-directed RNA polymerases I, II, and III subunit RPABC2 K03014 RPABC2; DNA-directed RNA polymerases I, II, and III subunit RPABC2
F 122537305 DNA-directed RNA polymerase II subunit RPB7 K03015 RPB7; DNA-directed RNA polymerase II subunit RPB7
F 122529735 uncharacterized protein LOC122529735 isoform X1 K03016 RPABC3; DNA-directed RNA polymerases I, II, and III subunit RPABC3
F 122539196 DNA-directed RNA polymerase II subunit RPB9 K03017 RPB9; DNA-directed RNA polymerase II subunit RPB9
F 122535835 DNA-directed RNA polymerases I, II, and III subunit RPABC5 K03007 RPABC5; DNA-directed RNA polymerases I, II, and III subunit RPABC5
F 122535813 DNA-directed RNA polymerase II subunit RPB11 K03008 RPB11; DNA-directed RNA polymerase II subunit RPB11
F 122531181 DNA-directed RNA polymerases I, II, and III subunit RPABC4 K03009 RPABC4; DNA-directed RNA polymerases I, II, and III subunit RPABC4
E Cul4-CSA complex
F 122537109 RING-box protein 1A K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
F 122531513 cullin-4A isoform X1 K10609 CUL4; cullin 4
F 122529633 DNA damage-binding protein 1 K10610 DDB1; DNA damage-binding protein 1
E Other TCR factor
F 122532972 DNA excision repair protein ERCC-6-like isoform X1 K10841 ERCC6; DNA excision repair protein ERCC-6
F 122532651 transcription elongation factor 1 homolog K25829 ELOF1; transcription elongation factor 1
D TFIIH complex
E 122531710 general transcription and DNA repair factor IIH helicase subunit XPB K10843 ERCC3; DNA excision repair protein ERCC-3 [EC:5.6.2.4]
E 122527795 general transcription and DNA repair factor IIH helicase subunit XPD K10844 ERCC2; DNA excision repair protein ERCC-2 [EC:5.6.2.3]
E 122526940 general transcription factor IIH subunit 1 K03141 TFIIH1; transcription initiation factor TFIIH subunit 1
E 122536799 general transcription factor IIH subunit 2 K03142 TFIIH2; transcription initiation factor TFIIH subunit 2
E 122528323 general transcription factor IIH subunit 3 isoform X1 K03143 TFIIH3; transcription initiation factor TFIIH subunit 3
E 122537325 general transcription factor IIH subunit 4 K03144 TFIIH4; transcription initiation factor TFIIH subunit 4
E 122531106 general transcription factor IIH subunit 5 K10845 TTDA; TFIIH basal transcription factor complex TTD-A subunit
E 122536728 cyclin-dependent kinase 7 K02202 CDK7; cyclin-dependent kinase 7 [EC:2.7.11.22 2.7.11.23]
E 122526907 cyclin-H K06634 CCNH; cyclin H
E 122538333 CDK-activating kinase assembly factor MAT1 K10842 MNAT1; CDK-activating kinase assembly factor MAT1
D RPA (replication factor A)
E 122529615 replication protein A 70 kDa DNA-binding subunit isoform X1 K07466 RFA1; replication factor A1
E 122526974 replication protein A 32 kDa subunit-like K10739 RFA2; replication factor A2
E 122526979 replication protein A 32 kDa subunit-like K10739 RFA2; replication factor A2
E 122535082 replication protein A 14 kDa subunit-like K10740 RPA3; replication factor A3
D Other NER factors
E 122538349 DNA repair protein complementing XP-A cells homolog K10847 XPA; DNA-repair protein complementing XP-A cells
E 122529894 DNA excision repair protein ERCC-1 K10849 ERCC1; DNA excision repair protein ERCC-1
E 122532482 DNA repair endonuclease XPF isoform X1 K10848 ERCC4; DNA excision repair protein ERCC-4 [EC:3.1.-.-]
E 122530880 DNA ligase 1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
E 122529974 MMS19 nucleotide excision repair protein K15075 MET18; DNA repair/transcription protein MET18/MMS19
E 122527056 cullin-3 K03869 CUL3; cullin 3
E 122535303 cullin-5 isoform X1 K10612 CUL5; cullin 5
E 122539106 elongin-C isoform X1 K03872 ELOC; elongin-C
E 122527565 elongin-B K03873 ELOB; elongin-B
E 122535646 protein lingerer isoform X1 K26545 UBAP2; ubiquitin-associated protein 2
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
E 122534281 DNA mismatch repair protein Msh2 K08735 MSH2; DNA mismatch repair protein MSH2
E 122531199 probable DNA mismatch repair protein Msh6 isoform X1 K08737 MSH6; DNA mismatch repair protein MSH6
D MutL homologs
E 122533092 DNA mismatch repair protein Mlh1 isoform X1 K08734 MLH1; DNA mismatch repair protein MLH1
E 122536745 mismatch repair endonuclease PMS2-like K10858 PMS2; DNA mismatch repair protein PMS2
D DNA polymerase delta complex
E 122532701 DNA polymerase delta catalytic subunit isoform X1 K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
E 122535658 DNA polymerase delta subunit 2-like isoform X1 K02328 POLD2; DNA polymerase delta subunit 2
E 122527240 DNA polymerase delta subunit 2-like K02328 POLD2; DNA polymerase delta subunit 2
D RPA (replication factor A)
E 122529615 replication protein A 70 kDa DNA-binding subunit isoform X1 K07466 RFA1; replication factor A1
E 122526974 replication protein A 32 kDa subunit-like K10739 RFA2; replication factor A2
E 122526979 replication protein A 32 kDa subunit-like K10739 RFA2; replication factor A2
E 122535082 replication protein A 14 kDa subunit-like K10740 RPA3; replication factor A3
D RFC (replication factor C)
E 122533778 replication factor C subunit 1 isoform X1 K10754 RFC1; replication factor C subunit 1
E 122528987 replication factor C subunit 2 K10755 RFC2_4; replication factor C subunit 2/4
E 122535426 replication factor C subunit 4 K10755 RFC2_4; replication factor C subunit 2/4
E 122531716 replication factor C subunit 5 K10756 RFC3_5; replication factor C subunit 3/5
E 122527046 replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
D Other MMR factors
E 122538843 proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
E 122527270 high mobility group protein DSP1-like K10802 HMGB1; high mobility group protein B1
E 122530880 DNA ligase 1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D MRN(MRX) complex
E 122532836 double-strand break repair protein MRE11 isoform X1 K10865 MRE11; double-strand break repair protein MRE11
E 122538463 DNA repair protein RAD50 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
D BRCA1-core complex
E 122535471 BRCA1-associated RING domain protein 1-like isoform X1 K10683 BARD1; BRCA1-associated RING domain protein 1
D BRCA1-A complex
E 122528529 BRISC and BRCA1-A complex member 1-like K20776 BABAM; BRISC and BRCA1-A complex member 1
E 122537643 BRISC and BRCA1-A complex member 2-like K12173 BRE; BRCA1-A complex subunit BRE
E 122529921 lys-63-specific deubiquitinase BRCC36-like K11864 BRCC3; BRCA1/BRCA2-containing complex subunit 3 [EC:3.4.19.-]
D BRCA1-B complex
E 122528286 Fanconi anemia group J protein-like K15362 BRIP1; fanconi anemia group J protein [EC:5.6.2.3]
E 122538040 DNA topoisomerase 2-binding protein 1-A K10728 TOPBP1; topoisomerase (DNA) II binding protein 1
D BRCA1-C complex
E 122532836 double-strand break repair protein MRE11 isoform X1 K10865 MRE11; double-strand break repair protein MRE11
E 122538463 DNA repair protein RAD50 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
D BRCA complex
E 122527511 DNA repair protein RAD51 homolog A-like K04482 RAD51; DNA repair protein RAD51
D RecA family proteins
E 122527511 DNA repair protein RAD51 homolog A-like K04482 RAD51; DNA repair protein RAD51
E 122532365 DNA repair protein RAD51 homolog 4 K10871 RAD51L3; RAD51-like protein 3
E 122528774 DNA repair protein XRCC2 K10879 XRCC2; DNA-repair protein XRCC2
E 122528201 DNA repair protein XRCC3-like isoform X1 K10880 XRCC3; DNA-repair protein XRCC3
D Rad52 family proteins
D Rad54 family proteins
E 122527691 DNA repair and recombination protein RAD54-like K10875 RAD54L; DNA repair and recombination protein RAD54 and RAD54-like protein [EC:5.6.2.-]
E 122532630 uncharacterized protein LOC122532630 isoform X1 K10876 RAD54L2; RAD54-like protein 2 [EC:5.6.2.-]
E 122528218 DNA repair and recombination protein RAD54B-like isoform X1 K10877 RAD54B; DNA repair and recombination protein RAD54B [EC:5.6.2.-]
D RecQ family DNA helicases
E 122528110 ATP-dependent DNA helicase Q1-like K10899 RECQL; ATP-dependent DNA helicase Q1 [EC:5.6.2.4]
E 122534295 Bloom syndrome protein homolog isoform X1 K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 122535895 ATP-dependent DNA helicase Q4 isoform X1 K10730 RECQL4; ATP-dependent DNA helicase Q4 [EC:5.6.2.4]
D Bloom's syndrome complex (BTR)
E 122534295 Bloom syndrome protein homolog isoform X1 K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 122530350 DNA topoisomerase 3-alpha K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 122534893 DNA topoisomerase 3-beta-1 isoform X1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
D RPA (replication factor A)
E 122529615 replication protein A 70 kDa DNA-binding subunit isoform X1 K07466 RFA1; replication factor A1
E 122526974 replication protein A 32 kDa subunit-like K10739 RFA2; replication factor A2
E 122526979 replication protein A 32 kDa subunit-like K10739 RFA2; replication factor A2
E 122535082 replication protein A 14 kDa subunit-like K10740 RPA3; replication factor A3
D Protein phosphatase 4
E 122529476 serine/threonine-protein phosphatase 4 catalytic subunit K15423 PPP4C; serine/threonine-protein phosphatase 4 catalytic subunit [EC:3.1.3.16]
E 122532619 serine/threonine-protein phosphatase 4 regulatory subunit 1-like K15424 PPP4R1; serine/threonine-protein phosphatase 4 regulatory subunit 1
E 122527042 serine/threonine-protein phosphatase 4 regulatory subunit 2-like K15425 PPP4R2; serine/threonine-protein phosphatase 4 regulatory subunit 2
E 122529620 serine/threonine-protein phosphatase 4 regulatory subunit 3 K17491 SMEK; protein phosphatase 4 regulatory subunit 3
E 122530802 serine/threonine-protein phosphatase 4 regulatory subunit 4-like isoform X1 K15426 PPP4R4; serine/threonine-protein phosphatase 4 regulatory subunit 4
D AP-5 complex
D SMC5-SMC6 complex
E 122527356 structural maintenance of chromosomes protein 5 isoform X1 K22803 SMC5; structural maintenance of chromosomes protein 5
E 122533722 structural maintenance of chromosomes protein 6 K22804 SMC6; structural maintenance of chromosomes protein 6
E 122528310 non-structural maintenance of chromosomes element 1 homolog K22817 NSMCE1; non-structural maintenance of chromosomes element 1 [EC:2.3.2.27]
E 122534824 non-structural maintenance of chromosomes element 3 homolog isoform X1 K22823 NSMCE3; non-structural maintenance of chromosomes element 3
E 122529465 non-structural maintenance of chromosomes element 4 homolog A K22825 NSMCE4; non-structural maintenance of chromosomes element 4
D Other HR factors
E 122533393 crossover junction endonuclease EME1 isoform X1 K10882 EME1; crossover junction endonuclease EME1 [EC:3.1.22.-]
E 122536236 exonuclease 3'-5' domain-containing protein 2 K20777 EXD2; exonuclease 3'-5' domain-containing protein 2 [EC:3.1.11.1]
E 122528800 crossover junction endonuclease MUS81 isoform X1 K08991 MUS81; crossover junction endonuclease MUS81 [EC:3.1.22.-]
E 122533793 26S proteasome complex subunit SEM1 K10881 SHFM1; 26 proteasome complex subunit DSS1
E 122533899 DNA repair protein SWI5 homolog K10991 SWI5; DNA repair protein Swi5/Sae3
E 122534903 structure-specific endonuclease subunit slx1 isoform X1 K15078 SLX1; structure-specific endonuclease subunit SLX1 [EC:3.6.1.-]
E 122534020 flap endonuclease GEN isoform X1 K15338 GEN1; holliday junction resolvase GEN1/YEN1 [EC:3.1.-.-]
E 122532449 spatacsin isoform X1 K19026 SPG11; spatacsin
E 122538609 uncharacterized protein LOC122538609 K19027 ZFYVE26; zinc finger FYVE domain-containing protein 26
E 122534557 mortality factor 4-like protein 1 K11339 MORF4L1; mortality factor 4-like protein 1
E 122534294 fidgetin-like protein 1 isoform X1 K22766 FIGNL1; fidgetin-like protein 1 [EC:5.6.2.-]
E 122531258 uncharacterized protein LOC122531258 K23112 BRAT1; BRCA1-associated ATM activator 1
E 122530139 dynein axonemal assembly factor 11 isoform X1 K23456 CFAP410; cilla- and flagella-associated protein
E 122538719 BRCA2-interacting transcriptional repressor EMSY K25790 EMSY; BRCA2-interacting transcriptional repressor EMSY
E 122527505 heat shock factor 2-binding protein-like K25791 HSF2BP; heat shock factor 2-binding protein
E 122529450 protein MMS22-like isoform X1 K26125 MMS22L; protein MMS22-like
E 122528850 tonsoku-like protein K09257 NFKBIL2; NF-kappa-B inhibitor-like protein 2
E 122531066 biorientation of chromosomes in cell division protein 1-like 1 isoform X1 K27262 BOD1L1; biorientation of chromosomes in cell division protein 1-like 1
C NHEJ (non-homologous end-joining)
D DNA-PK complex
E 122534137 X-ray repair cross-complementing protein 6-like K10884 XRCC6; ATP-dependent DNA helicase 2 subunit 1
E 122537534 X-ray repair cross-complementing protein 5-like K10885 XRCC5; ATP-dependent DNA helicase 2 subunit 2
E 122538058 DNA-dependent protein kinase catalytic subunit-like K06642 PRKDC; DNA-dependent protein kinase catalytic subunit [EC:2.7.11.1]
D MRX complex
E 122532836 double-strand break repair protein MRE11 isoform X1 K10865 MRE11; double-strand break repair protein MRE11
E 122538463 DNA repair protein RAD50 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
D DNA Ligase 4 complex
E 122537552 DNA ligase 4 K10777 LIG4; DNA ligase 4 [EC:6.5.1.1]
E 122534238 DNA repair protein XRCC4-like K10886 XRCC4; DNA-repair protein XRCC4
E 122531080 uncharacterized protein LOC122531080 K10980 NHEJ1; non-homologous end-joining factor 1
D X-family DNA polymerases
E 122533770 DNA polymerase beta-like K02330 POLB; DNA polymerase beta [EC:2.7.7.7 4.2.99.-]
D Other NHEJ factors
E 122535622 aprataxin K10863 APTX; aprataxin [EC:3.6.1.70 3.6.1.71 3.6.1.72]
E 122529067 aprataxin and PNK-like factor isoform X1 K13295 APLF; aprataxin and PNK-like factor [EC:3.1.-.-]
E 122534742 protein artemis K10887 DCLRE1C; DNA cross-link repair 1C protein [EC:3.1.-.-]
C FA (Fanconi anemia) pathway
D FA core complex
E 122534695 E3 ubiquitin-protein ligase FANCL isoform X1 K10606 FANCL; E3 ubiquitin-protein ligase FANCL [EC:2.3.2.27]
D FA core complex binding factors
E 122529969 ubiquitin-conjugating enzyme E2 T-like K13960 UBE2T; ubiquitin-conjugating enzyme E2 T [EC:2.3.2.23]
D Bloom's syndrome complex (BTR)
E 122534295 Bloom syndrome protein homolog isoform X1 K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 122530350 DNA topoisomerase 3-alpha K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 122534893 DNA topoisomerase 3-beta-1 isoform X1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
D FANCD2-I complex
E 122533699 Fanconi anemia group I protein isoform X1 K10895 FANCI; fanconi anemia group I protein
D Downstream FA components
E 122528286 Fanconi anemia group J protein-like K15362 BRIP1; fanconi anemia group J protein [EC:5.6.2.3]
D Other FA pathway factors
E 122527511 DNA repair protein RAD51 homolog A-like K04482 RAD51; DNA repair protein RAD51
E 122530064 ubiquitin carboxyl-terminal hydrolase 1 K11832 USP1; ubiquitin carboxyl-terminal hydrolase 1 [EC:3.4.19.12]
E 122534462 WD repeat-containing protein 48 isoform X1 K15361 WDR48; WD repeat-containing protein 48
C Other DSBR factors
D Protein phosphatase 6
E 122538949 serine/threonine-protein phosphatase 6 catalytic subunit K15498 PPP6C; serine/threonine-protein phosphatase 6 catalytic subunit [EC:3.1.3.16]
E 122535902 serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X1 K15501 PPP6R3; serine/threonine-protein phosphatase 6 regulatory subunit 3
E 122529452 serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A-like isoform X1 K15502 ANKRD28; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A
D Ubiquitin ligases
E 122528763 uncharacterized protein LOC122528763 K20779 RNF168; E3 ubiquitin-protein ligase RNF168 [EC:2.3.2.31]
E 122534831 E3 ubiquitin-protein ligase HERC2 K10595 HERC2; E3 ubiquitin-protein ligase HERC2 [EC:2.3.2.26]
D Others
E 122528942 telomerase Cajal body protein 1 isoform X1 K23314 WRAP53; telomerase Cajal body protein 1
E 122527522 gastrulation defective protein 1 homolog K24752 WDR70; WD repeat-containing protein 70
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
D 122532452 DNApol-eta isoform X1 K03509 POLH; DNA polymerase eta [EC:2.7.7.7]
D 122528103 DNA polymerase iota K03510 POLI; DNA polymerase iota [EC:2.7.7.7]
D 122533396 DNA repair protein REV1 isoform X1 K03515 REV1; DNA repair protein REV1 [EC:2.7.7.-]
C B-family DNA polymerases
D 122530559 DNA polymerase zeta catalytic subunit K02350 REV3L; DNA polymerase zeta [EC:2.7.7.7]
C A-family DNA polymerase
C Rad6 epistasis group
D 122532840 ubiquitin-conjugating enzyme E2-17 kDa isoform X1 K10573 UBE2A; ubiquitin-conjugating enzyme E2 A [EC:2.3.2.23]
D 122538796 E3 ubiquitin-protein ligase RAD18-like isoform X1 K10627 RAD18; E3 ubiquitin-protein ligase RAD18 [EC:2.3.2.27]
D 122532376 ubiquitin-conjugating enzyme E2 variant 2 isoform X1 K10704 UBE2V; ubiquitin-conjugating enzyme E2 variant
D 122532849 ubiquitin-conjugating enzyme E2 N K10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23]
C Other TLS factors
D 122538843 proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
D 122535942 DNA-dependent metalloprotease dvc-1 K24051 SPRTN; SprT-like domain-contaning protein Spartan
B Check point factors
C Rad9-Hus1-Rad1 complex
D 122529687 cell cycle checkpoint control protein RAD9A isoform X1 K10994 RAD9A; cell cycle checkpoint control protein RAD9A [EC:3.1.11.2]
D 122534385 checkpoint protein HUS1 K10903 HUS1; HUS1 checkpoint protein
D 122537104 cell cycle checkpoint protein RAD1 isoform X1 K02830 HRAD1; cell cycle checkpoint protein [EC:3.1.11.2]
C HRAD17(Rad24)-RFC complex
D 122530526 cell cycle checkpoint protein RAD17 isoform X1 K06662 HRAD17; cell cycle checkpoint protein
D 122528987 replication factor C subunit 2 K10755 RFC2_4; replication factor C subunit 2/4
D 122535426 replication factor C subunit 4 K10755 RFC2_4; replication factor C subunit 2/4
D 122531716 replication factor C subunit 5 K10756 RFC3_5; replication factor C subunit 3/5
D 122527046 replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
C Rad17-Mec3-Ddc1 complex
D 122537104 cell cycle checkpoint protein RAD1 isoform X1 K02830 HRAD1; cell cycle checkpoint protein [EC:3.1.11.2]
C FPC (fork protection complex)
D 122539020 protein timeless homolog isoform X1 K10997 TIMELESS; replication fork protection complex subunit TIMELESS/Tof1/Swi1
D 122538342 protein TIPIN homolog K10998 TIPIN; replication fork protection complex subunit TIPIN/Csm3/Swi3
C Triple T complex
D 122529474 TELO2-interacting protein 1 homolog K20403 TTI1; TELO2-interacting protein 1
D 122529667 TELO2-interacting protein 2-like K23115 TTI2; TELO2-interacting protein 2
C BAG6-UBL4A-GET4 complex
D 122536718 large proline-rich protein BAG6 isoform X1 K23390 BAG6; large proline-rich protein BAG6
D 122526944 ubiquitin-like protein 4A K23388 UBL4; ubiquitin-like protein 4
D 122537890 Golgi to ER traffic protein 4 homolog K23387 GET4; golgi to ER traffic protein 4
C Other check point factors
D 122529446 serine/threonine-protein kinase atr K06640 ATR; serine/threonine-protein kinase ATR [EC:2.7.11.1]
D 122530600 serine-protein kinase ATM isoform X1 K04728 ATM; serine-protein kinase ATM [EC:2.7.11.1]
D 122534255 serine/threonine-protein kinase grp K02216 CHEK1; serine/threonine-protein kinase CHEK1 [EC:2.7.11.1]
D 122530057 ovarian-specific serine/threonine-protein kinase Lok-like K06641 CHEK2; serine/threonine-protein kinase CHEK2 [EC:2.7.11.1]
D 122536061 14-3-3 protein zeta isoform X1 K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
D 122528324 14-3-3 protein epsilon K06630 YWHAE; 14-3-3 protein epsilon
D 122531373 wee1-like protein kinase isoform X1 K06632 WEE1; wee1-like protein kinase [EC:2.7.11.1]
D 122532637 period circadian protein isoform X1 K02633 PER2; period circadian protein 2
D 122539137 plastin-2 isoform X1 K17336 PLS3; plastin-3
D 122531687 protein downstream neighbor of son homolog isoform X1 K22422 DONSON; protein downstream neighbor of Son
D 122533580 KN motif and ankyrin repeat domain-containing protein 2 isoform X1 K22808 KANK; KN motif and ankyrin repeat domain-containing protein
D 122537797 vacuolar protein sorting-associated protein 4 K12196 VPS4; vacuolar protein-sorting-associated protein 4
D 122531253 abscission/NoCut checkpoint regulator K24778 ZFYVE19; abscission/NoCut checkpoint regulator
D 122529054 replication stress response regulator SDE2 K25059 SDE2; replication stress response regulator SDE2
B Other factors with a suspected DNA repair function
C DNA polymerases
D 122533867 DNA polymerase theta K02349 POLQ; DNA polymerase theta [EC:2.7.7.7]
D 122536003 myb-binding protein 1A K02331 POL5; DNA polymerase phi [EC:2.7.7.7]
D 122534132 DNA-directed primase/polymerase protein-like K22761 PRIMPOL; DNA-directed primase/polymerase protein [EC:2.7.7.102 2.7.7.7]
C Nucleases
D 122533481 uncharacterized protein LOC122533481 K10791 TREX2; three prime repair exonuclease 2 [EC:3.1.11.2]
C Helicases
D 122534296 helicase POLQ-like K19178 HELQ; POLQ-like helicase [EC:5.6.2.4]
C PSO4 complex
D 122530893 pre-mRNA-processing factor 19 K10599 PRPF19; pre-mRNA-processing factor 19 [EC:2.3.2.27]
D 122538059 cell division cycle 5-like protein isoform X1 K12860 CDC5L; pre-mRNA-splicing factor CDC5/CEF1
D 122536319 pre-mRNA-splicing factor SPF27 K12861 BCAS2; pre-mRNA-splicing factor SPF27
D 122536512 pleiotropic regulator 1 K12862 PLRG1; pleiotropic regulator 1
C Modulation of nucleotide pools
D 122539114 7,8-dihydro-8-oxoguanine triphosphatase-like K17816 NUDT1; 8-oxo-dGTP diphosphatase / 2-hydroxy-dATP diphosphatase [EC:3.6.1.55 3.6.1.56]
D 122533234 8-oxo-dGDP phosphatase NUDT18 K17817 NUDT18; 8-oxo-dGDP phosphatase [EC:3.6.1.58]
D 122536708 ribonucleoside-diphosphate reductase large subunit K10807 RRM1; ribonucleoside-diphosphate reductase subunit M1 [EC:1.17.4.1]
D 122538646 ribonucleoside-diphosphate reductase subunit M2 B isoform X1 K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]
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AProkaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D 122533088 deoxyribodipyrimidine photo-lyase isoform X1 K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]
C BER (base exicision repair)
D DNA glycosylases
E 122528337 single-strand selective monofunctional uracil DNA glycosylase isoform X1 K10800 SMUG1; single-strand selective monofunctional uracil DNA glycosylase [EC:3.2.2.-]
E 122537603 putative 3-methyladenine DNA glycosylase K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]
E 122536248 endonuclease III-like protein 1 isoform X1 K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
D RecJ
D DNA ligase
D DNA polymerase I
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase complex (RNAP)
E TRCF (transcription-repair coupling factor)
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
D Molecular matchmaker
D Strand discrimination factor
D DNA exonucleases
D DNA polymerase III holoenzyme
D DNA ligase
D Other MMR factors
E 122529177 single-stranded DNA-binding protein, mitochondrial isoform X1 K03111 ssb; single-strand DNA-binding protein
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D RecBC pathway proteins
D RecFOR pathway proteins
D AddAB pathway proteins
D Other HR factor
D Archaeal homologous recombinant proteins
C NHEJ (non-homologous end-joining)
D Two-component NHEJ DNA repair complex
D SHIIR (short-homology-independent illegitimate recombination)
E Facilitator
E Supressor
D SHDIR (short-homology-dependent illegitimate recombination)
E RecET pathway
E Facilitator
E Supressor
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
C Other SOS response factors
D 122529177 single-stranded DNA-binding protein, mitochondrial isoform X1 K03111 ssb; single-strand DNA-binding protein
B Other factors with a suspected DNA repair function
C DNA polymerase
C DNA helicases
C Modulation of nucleotide pools
C Others
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: March 29, 2024