+F Repair protein KO
#
DNA Repair and Recombination Proteins - Gymnodraco acuticeps
%
!
AEukaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D 117560919 mgmt; LOW QUALITY PROTEIN: methylated-DNA--protein-cysteine methyltransferase K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
D 117561061 alkbh2; DNA oxidative demethylase ALKBH2 isoform X1 K10859 ALKBH2; DNA oxidative demethylase [EC:1.14.11.33]
D 117557472 alkbh3; alpha-ketoglutarate-dependent dioxygenase alkB homolog 3 K10860 ALKBH3; mRNA N1-methyladenine demethylase [EC:1.14.11.54]
D 117532943 ascc3; LOW QUALITY PROTEIN: activating signal cointegrator 1 complex subunit 3 K18663 ASCC3; activating signal cointegrator complex subunit 3 [EC:5.6.2.4]
D 117545581 deoxyribodipyrimidine photo-lyase-like K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]
D 117545582 deoxyribodipyrimidine photo-lyase-like isoform X1 K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]
C BER (base exicision repair)
D DNA glycosylases
E 117561060 unga; uracil DNA glycosylase a K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E 117560133 cyclin-O protein B K10861 UDG2; uracil-DNA glycosylase 2 [EC:3.2.2.-]
E 117557471 tdg.2; G/T mismatch-specific thymine DNA glycosylase isoform X1 K20813 TDG; thymine-DNA glycosylase [EC:3.2.2.29]
E 117557479 tdg.1; thymine DNA glycosylase, tandem duplicate 1 isoform X1 K20813 TDG; thymine-DNA glycosylase [EC:3.2.2.29]
E 117548619 mpg; LOW QUALITY PROTEIN: DNA-3-methyladenine glycosylase K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]
E 117554879 smug1; single-strand selective monofunctional uracil DNA glycosylase K10800 SMUG1; single-strand selective monofunctional uracil DNA glycosylase [EC:3.2.2.-]
E 117550892 mutyh; adenine DNA glycosylase isoform X1 K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
E 117543059 mbd4; methyl-CpG-binding domain protein 4 K10801 MBD4; methyl-CpG-binding domain protein 4 [EC:3.2.2.-]
E 117543093 ogg1; N-glycosylase/DNA lyase K03660 OGG1; N-glycosylase/DNA lyase [EC:3.2.2.- 4.2.99.18]
E 117538942 neil1; endonuclease 8-like 1 isoform X1 K10567 NEIL1; endonuclease VIII-like 1 [EC:3.2.2.- 4.2.99.18]
E 117553611 neil3; endonuclease 8-like 3 isoform X1 K10569 NEIL3; endonuclease VIII-like 3 [EC:3.2.2.- 4.2.99.18]
E 117561621 nthl1; endonuclease III-like protein 1 isoform X1 K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
E 117552480 apex1; DNA-(apurinic or apyrimidinic site) lyase K10771 APEX1; AP endonuclease 1 [EC:3.1.11.2]
E 117547443 apex2; LOW QUALITY PROTEIN: DNA-(apurinic or apyrimidinic site) lyase 2 K10772 APEX2; AP endonuclease 2 [EC:3.1.11.2]
D Long Patch-BER factors
E DNA polymerase delta complex
F 117544104 pold1; DNA polymerase delta catalytic subunit K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
F 117543893 pold2; DNA polymerase delta subunit 2 K02328 POLD2; DNA polymerase delta subunit 2
F 117552642 pold3; DNA polymerase delta subunit 3 K03504 POLD3; DNA polymerase delta subunit 3
F 117556495 pold4; DNA polymerase delta subunit 4 isoform X1 K03505 POLD4; DNA polymerase delta subunit 4
E DNA polymerase epsilon complex
F 117535774 pole; DNA polymerase epsilon catalytic subunit A K02324 POLE; DNA polymerase epsilon subunit 1 [EC:2.7.7.7]
F 117556411 pole2; DNA polymerase epsilon subunit 2 isoform X1 K02325 POLE2; DNA polymerase epsilon subunit 2 [EC:2.7.7.7]
F 117557822 pole3; DNA polymerase epsilon subunit 3 K02326 POLE3; DNA polymerase epsilon subunit 3 [EC:2.7.7.7]
E 117561313 pcna; proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
E 117543668 fen1; flap endonuclease 1 K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
E 117545496 zgc:110269; probable flap endonuclease 1 homolog isoform X1 K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
E 117540943 lig1; DNA ligase 1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
D Short Patch-BER factors
E 117560525 polb; DNA polymerase beta K02330 POLB; DNA polymerase beta [EC:2.7.7.7 4.2.99.-]
E 117562160 xrcc1; DNA repair protein XRCC1 isoform X1 K10803 XRCC1; DNA-repair protein XRCC1
E 117536614 lig3; LOW QUALITY PROTEIN: DNA ligase 3 K10776 LIG3; DNA ligase 3 [EC:6.5.1.1]
D Other BER factors
E 117560384 tdp1; tyrosyl-DNA phosphodiesterase 1 isoform X1 K10862 TDP1; tyrosyl-DNA phosphodiesterase 1 [EC:3.1.4.-]
E 117561997 aptx; aprataxin isoform X1 K10863 APTX; aprataxin [EC:3.6.1.70 3.6.1.71 3.6.1.72]
E 117551936 aplf; aprataxin and PNK-like factor isoform X1 K13295 APLF; aprataxin and PNK-like factor [EC:3.1.-.-]
E 117557379 pnkp; bifunctional polynucleotide phosphatase/kinase isoform X1 K08073 PNKP; bifunctional polynucleotide phosphatase/kinase [EC:3.1.3.32 2.7.1.78]
E 117540466 hmgb1b; high mobility group protein B1b K10802 HMGB1; high mobility group protein B1
E 117540560 hmgb1a; high mobility group protein B1a K10802 HMGB1; high mobility group protein B1
E 117561600 poll; DNA polymerase lambda isoform X1 K03512 POLL; DNA polymerase lambda [EC:2.7.7.7 4.2.99.-]
E 117533820 parp1; poly [ADP-ribose] polymerase 1 K24070 PARP1; poly [ADP-ribose] polymerase 1 [EC:2.4.2.30]
E 117551090 parp3; protein mono-ADP-ribosyltransferase PARP3 isoform X1 K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
E 117540854 parp2; poly [ADP-ribose] polymerase 2 isoform X1 K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
E 117533974 parp4; LOW QUALITY PROTEIN: protein mono-ADP-ribosyltransferase PARP4 K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E XPC-HR23B-CETN2 complex
F 117542087 xpc; DNA repair protein complementing XP-C cells K10838 XPC; xeroderma pigmentosum group C-complementing protein
F 117537703 rad23aa; LOW QUALITY PROTEIN: RAD23 homolog A, nucleotide excision repair protein a K10839 RAD23; UV excision repair protein RAD23
F 117539313 rad23b; UV excision repair protein RAD23 homolog B K10839 RAD23; UV excision repair protein RAD23
F 117560556 rad23ab; RAD23 homolog A, nucleotide excision repair protein b isoform X1 K10839 RAD23; UV excision repair protein RAD23
F 117556973 cetn2; caltractin K10840 CETN2; centrin-2
E Cul4-DDB2 complex
F 117534788 rbx1; E3 ubiquitin-protein ligase RBX1 K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
F 117543485 cul4b; cullin-4B K10609 CUL4; cullin 4
F 117548354 cul4a; cullin-4A isoform X1 K10609 CUL4; cullin 4
F 117549362 ddb1; DNA damage-binding protein 1 K10610 DDB1; DNA damage-binding protein 1
F 117538908 ddb2; DNA damage-binding protein 2 isoform X1 K10140 DDB2; DNA damage-binding protein 2
E NER4 complex
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase II complex
F 117552702 polr2a; LOW QUALITY PROTEIN: DNA-directed RNA polymerase II subunit RPB1 K03006 RPB1; DNA-directed RNA polymerase II subunit RPB1 [EC:2.7.7.6]
F 117539076 polr2c; DNA-directed RNA polymerase II subunit RPB3 K03011 RPB3; DNA-directed RNA polymerase II subunit RPB3
F 117553096 polr2d; DNA-directed RNA polymerase II subunit RPB4 isoform X1 K03012 RPB4; DNA-directed RNA polymerase II subunit RPB4
F 117555070 polr2eb; LOW QUALITY PROTEIN: DNA-directed RNA polymerases I, II, and III subunit RPABC1 K03013 RPABC1; DNA-directed RNA polymerases I, II, and III subunit RPABC1
F 117537146 polr2f; DNA-directed RNA polymerases I, II, and III subunit RPABC2 K03014 RPABC2; DNA-directed RNA polymerases I, II, and III subunit RPABC2
F 117555866 polr2gl; DNA-directed RNA polymerase II subunit RPB7 isoform X1 K03015 RPB7; DNA-directed RNA polymerase II subunit RPB7
F 117544276 polr2h; DNA-directed RNA polymerases I, II, and III subunit RPABC3 isoform X1 K03016 RPABC3; DNA-directed RNA polymerases I, II, and III subunit RPABC3
F 117551680 polr2i; DNA-directed RNA polymerase II subunit RPB9 K03017 RPB9; DNA-directed RNA polymerase II subunit RPB9
F 117547046 polr2l; DNA-directed RNA polymerases I, II, and III subunit RPABC5 isoform X1 K03007 RPABC5; DNA-directed RNA polymerases I, II, and III subunit RPABC5
F 117536166 polr2k; DNA-directed RNA polymerases I, II, and III subunit RPABC4 K03009 RPABC4; DNA-directed RNA polymerases I, II, and III subunit RPABC4
E Cul4-CSA complex
F 117534788 rbx1; E3 ubiquitin-protein ligase RBX1 K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
F 117543485 cul4b; cullin-4B K10609 CUL4; cullin 4
F 117548354 cul4a; cullin-4A isoform X1 K10609 CUL4; cullin 4
F 117549362 ddb1; DNA damage-binding protein 1 K10610 DDB1; DNA damage-binding protein 1
F 117558573 ercc8; DNA excision repair protein ERCC-8 isoform X1 K10570 ERCC8; DNA excision repair protein ERCC-8
E Other TCR factor
F 117536802 ercc6; DNA excision repair protein ERCC-6 isoform X1 K10841 ERCC6; DNA excision repair protein ERCC-6
F 117550419 uvssa; UV-stimulated scaffold protein A K23720 UVSSA; UV-stimulated scaffold protein A
F 117537977 elof1; transcription elongation factor 1 homolog K25829 ELOF1; transcription elongation factor 1
D TFIIH complex
E 117549260 ercc3; general transcription and DNA repair factor IIH helicase subunit XPB K10843 ERCC3; DNA excision repair protein ERCC-3 [EC:5.6.2.4]
E 117555613 general transcription and DNA repair factor IIH helicase subunit XPD K10844 ERCC2; DNA excision repair protein ERCC-2 [EC:5.6.2.3]
E 117538800 gtf2h1; general transcription factor IIH subunit 1 K03141 TFIIH1; transcription initiation factor TFIIH subunit 1
E 117541189 gtf2h2; general transcription factor IIH subunit 2 isoform X1 K03142 TFIIH2; transcription initiation factor TFIIH subunit 2
E 117543941 gtf2h3; general transcription factor IIH subunit 3 isoform X1 K03143 TFIIH3; transcription initiation factor TFIIH subunit 3
E 117539108 general transcription factor IIH subunit 4-like K03144 TFIIH4; transcription initiation factor TFIIH subunit 4
E 117539109 general transcription factor IIH subunit 4-like K03144 TFIIH4; transcription initiation factor TFIIH subunit 4
E 117556252 gtf2h5; general transcription factor IIH subunit 5 K10845 TTDA; TFIIH basal transcription factor complex TTD-A subunit
E 117536036 cdk7; cyclin-dependent kinase 7 K02202 CDK7; cyclin-dependent kinase 7 [EC:2.7.11.22 2.7.11.23]
E 117562465 ccnh; cyclin-H K06634 CCNH; cyclin H
E 117549937 mnat1; CDK-activating kinase assembly factor MAT1 K10842 MNAT1; CDK-activating kinase assembly factor MAT1
D RPA (replication factor A)
E 117533891 rpa1; replication protein A 70 kDa DNA-binding subunit K07466 RFA1; replication factor A1
E 117534433 replication protein A 70 kDa DNA-binding subunit-like isoform X1 K07466 RFA1; replication factor A1
E 117557341 LOW QUALITY PROTEIN: replication protein A 32 kDa subunit-like K10739 RFA2; replication factor A2
E 117557681 replication protein A 32 kDa subunit-like K10739 RFA2; replication factor A2
E 117559994 replication protein A 32 kDa subunit-like K10739 RFA2; replication factor A2
E 117558048 rpa3; replication protein A 14 kDa subunit K10740 RPA3; replication factor A3
D Other NER factors
E 117561285 xpa; DNA repair protein complementing XP-A cells K10847 XPA; DNA-repair protein complementing XP-A cells
E 117538372 ercc1; DNA excision repair protein ERCC-1 K10849 ERCC1; DNA excision repair protein ERCC-1
E 117546795 ercc4; DNA repair endonuclease XPF K10848 ERCC4; DNA excision repair protein ERCC-4 [EC:3.1.-.-]
E 117548192 ercc5; DNA repair protein complementing XP-G cells isoform X1 K10846 ERCC5; DNA excision repair protein ERCC-5
E 117540943 lig1; DNA ligase 1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
E 117563134 mms19; MMS19 nucleotide excision repair protein homolog K15075 MET18; DNA repair/transcription protein MET18/MMS19
E 117557385 cul3b; cullin-3b isoform X1 K03869 CUL3; cullin 3
E 117532639 cullin-3-like isoform X1 K03869 CUL3; cullin 3
E 117547773 cullin-5 isoform X1 K10612 CUL5; cullin 5
E 117561815 cullin-5-like isoform X1 K10612 CUL5; cullin 5
E 117561413 elongin-C K03872 ELOC; elongin-C
E 117545034 elongin-B-like K03873 ELOB; elongin-B
E 117548346 elob; elongin-B K03873 ELOB; elongin-B
E 117536675 eloa; elongin-A isoform X1 K15076 ELOA; elongin-A
E 117536799 eloal; elongin A, like K15076 ELOA; elongin-A
E 117543889 ubiquitin-associated protein 2-like isoform X1 K26545 UBAP2; ubiquitin-associated protein 2
E 117542567 ubap2l; LOW QUALITY PROTEIN: ubiquitin-associated protein 2-like K26545 UBAP2; ubiquitin-associated protein 2
E 117561914 ubap2a; LOW QUALITY PROTEIN: ubiquitin-associated protein 2a K26545 UBAP2; ubiquitin-associated protein 2
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
E 117544129 msh2; DNA mismatch repair protein Msh2 K08735 MSH2; DNA mismatch repair protein MSH2
E 117560993 msh3; DNA mismatch repair protein Msh3 isoform X1 K08736 MSH3; DNA mismatch repair protein MSH3
E 117542170 msh6; DNA mismatch repair protein Msh6 K08737 MSH6; DNA mismatch repair protein MSH6
D MutL homologs
E 117549513 pms1; PMS1 protein homolog 1 K10864 PMS1; DNA mismatch repair protein PMS1
E 117552605 mlh1; DNA mismatch repair protein Mlh1 isoform X1 K08734 MLH1; DNA mismatch repair protein MLH1
E 117544945 pms2; mismatch repair endonuclease PMS2 K10858 PMS2; DNA mismatch repair protein PMS2
E 117549988 mlh3; DNA mismatch repair protein Mlh3 isoform X1 K08739 MLH3; DNA mismatch repair protein MLH3
D DNA polymerase delta complex
E 117544104 pold1; DNA polymerase delta catalytic subunit K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
E 117543893 pold2; DNA polymerase delta subunit 2 K02328 POLD2; DNA polymerase delta subunit 2
E 117552642 pold3; DNA polymerase delta subunit 3 K03504 POLD3; DNA polymerase delta subunit 3
E 117556495 pold4; DNA polymerase delta subunit 4 isoform X1 K03505 POLD4; DNA polymerase delta subunit 4
D RPA (replication factor A)
E 117533891 rpa1; replication protein A 70 kDa DNA-binding subunit K07466 RFA1; replication factor A1
E 117534433 replication protein A 70 kDa DNA-binding subunit-like isoform X1 K07466 RFA1; replication factor A1
E 117557341 LOW QUALITY PROTEIN: replication protein A 32 kDa subunit-like K10739 RFA2; replication factor A2
E 117557681 replication protein A 32 kDa subunit-like K10739 RFA2; replication factor A2
E 117559994 replication protein A 32 kDa subunit-like K10739 RFA2; replication factor A2
E 117558048 rpa3; replication protein A 14 kDa subunit K10740 RPA3; replication factor A3
D RFC (replication factor C)
E 117543361 rfc1; replication factor C subunit 1 isoform X1 K10754 RFC1; replication factor C subunit 1
E 117541477 rfc2; replication factor C subunit 2 K10755 RFC2_4; replication factor C subunit 2/4
E 117558990 rfc4; replication factor C subunit 4 K10755 RFC2_4; replication factor C subunit 2/4
E 117552112 rfc5; replication factor C subunit 5 K10756 RFC3_5; replication factor C subunit 3/5
E 117540589 rfc3; replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
D Other MMR factors
E 117561313 pcna; proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
E 117545302 exo1; exonuclease 1 K10746 EXO1; exonuclease 1 [EC:3.1.-.-]
E 117540466 hmgb1b; high mobility group protein B1b K10802 HMGB1; high mobility group protein B1
E 117540560 hmgb1a; high mobility group protein B1a K10802 HMGB1; high mobility group protein B1
E 117540943 lig1; DNA ligase 1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
E 117533011 WD repeat-containing protein 76-like isoform X1 K24755 WDR76; WD repeat-containing protein 76
E 117533013 wdr76; WD repeat-containing protein 76 isoform X1 K24755 WDR76; WD repeat-containing protein 76
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D MRN(MRX) complex
E 117552207 mre11a; double-strand break repair protein MRE11 K10865 MRE11; double-strand break repair protein MRE11
E 117540204 rad50; DNA repair protein RAD50 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
E 117553893 nbn; nibrin K10867 NBN; nibrin
D BRCA1-core complex
E 117544825 breast cancer type 1 susceptibility protein homolog isoform X1 K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 117538377 bard1; LOW QUALITY PROTEIN: BRCA1-associated RING domain protein 1 K10683 BARD1; BRCA1-associated RING domain protein 1
D BRCA1-A complex
E 117544825 breast cancer type 1 susceptibility protein homolog isoform X1 K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 117560016 abraxas1; BRCA1-A complex subunit Abraxas 1 isoform X1 K20774 FAM175A; BRCA1-A complex subunit Abraxas
E 117538469 uimc1; neurofilament heavy polypeptide isoform X1 K20775 UIMC1; BRCA1-A complex subunit RAP80
E 117541049 babam1; BRISC and BRCA1-A complex member 1 K20776 BABAM; BRISC and BRCA1-A complex member 1
E 117539698 babam2; BRISC and BRCA1-A complex member 2 isoform X1 K12173 BRE; BRCA1-A complex subunit BRE
E 117542908 brcc3; lys-63-specific deubiquitinase BRCC36 K11864 BRCC3; BRCA1/BRCA2-containing complex subunit 3 [EC:3.4.19.-]
D BRCA1-B complex
E 117544825 breast cancer type 1 susceptibility protein homolog isoform X1 K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 117556319 brip1; Fanconi anemia group J protein isoform X1 K15362 BRIP1; fanconi anemia group J protein [EC:5.6.2.3]
E 117544659 topbp1; DNA topoisomerase 2-binding protein 1 isoform X1 K10728 TOPBP1; topoisomerase (DNA) II binding protein 1
D BRCA1-C complex
E 117544825 breast cancer type 1 susceptibility protein homolog isoform X1 K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 117543658 rbbp8; DNA endonuclease RBBP8 isoform X1 K20773 RBBP8; DNA endonuclease RBBP8 [EC:3.1.-.-]
E 117552207 mre11a; double-strand break repair protein MRE11 K10865 MRE11; double-strand break repair protein MRE11
E 117540204 rad50; DNA repair protein RAD50 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
E 117553893 nbn; nibrin K10867 NBN; nibrin
D BRCA complex
E 117544825 breast cancer type 1 susceptibility protein homolog isoform X1 K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 117540448 brca2; breast cancer type 2 susceptibility protein isoform X1 K08775 BRCA2; breast cancer 2 susceptibility protein
E 117538642 rad51; DNA repair protein RAD51 homolog 1 isoform X1 K04482 RAD51; DNA repair protein RAD51
D RecA family proteins
E 117538642 rad51; DNA repair protein RAD51 homolog 1 isoform X1 K04482 RAD51; DNA repair protein RAD51
E 117544786 rad51b; DNA repair protein RAD51 homolog 2 K10869 RAD51L1; RAD51-like protein 1
E 117559423 rad51c; DNA repair protein RAD51 homolog 3 isoform X1 K10870 RAD51L2; RAD51-like protein 2
E 117536613 rad51d; LOW QUALITY PROTEIN: DNA repair protein RAD51 homolog 4 K10871 RAD51L3; RAD51-like protein 3
E 117552608 xrcc2; DNA repair protein XRCC2 isoform X1 K10879 XRCC2; DNA-repair protein XRCC2
E 117555347 xrcc3; DNA repair protein XRCC3 K10880 XRCC3; DNA-repair protein XRCC3
D Rad52 family proteins
E 117545787 rad52; LOW QUALITY PROTEIN: DNA repair protein RAD52 homolog K10873 RAD52; DNA repair and recombination protein RAD52
E 117548909 rdm1; LOW QUALITY PROTEIN: RAD52 motif-containing protein 1 K10874 RDM1; RAD52 motif-containing protein 1
D Rad54 family proteins
E 117560465 rad54l; LOW QUALITY PROTEIN: DNA repair and recombination protein RAD54-like K10875 RAD54L; DNA repair and recombination protein RAD54 and RAD54-like protein [EC:5.6.2.-]
E 117548064 rad54l2; helicase ARIP4 K10876 RAD54L2; RAD54-like protein 2 [EC:5.6.2.-]
E 117541769 LOW QUALITY PROTEIN: helicase ARIP4-like K10876 RAD54L2; RAD54-like protein 2 [EC:5.6.2.-]
E 117553950 rad54b; DNA repair and recombination protein RAD54B K10877 RAD54B; DNA repair and recombination protein RAD54B [EC:5.6.2.-]
D RecQ family DNA helicases
E 117547166 recql; ATP-dependent DNA helicase Q1 isoform X1 K10899 RECQL; ATP-dependent DNA helicase Q1 [EC:5.6.2.4]
E 117557659 blm; Bloom syndrome protein homolog isoform X1 K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 117542667 recql4; ATP-dependent DNA helicase Q4 isoform X1 K10730 RECQL4; ATP-dependent DNA helicase Q4 [EC:5.6.2.4]
E 117544121 recql5; ATP-dependent DNA helicase Q5 isoform X1 K10902 RECQL5; ATP-dependent DNA helicase Q5 [EC:5.6.2.4]
D Bloom's syndrome complex (BTR)
E 117557659 blm; Bloom syndrome protein homolog isoform X1 K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 117541217 top3b; DNA topoisomerase 3-beta-1 isoform X1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 117534937 top3a; DNA topoisomerase 3-alpha isoform X1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 117558636 rmi1; recQ-mediated genome instability protein 1 K10990 RMI1; RecQ-mediated genome instability protein 1
E 117548695 rmi2; LOW QUALITY PROTEIN: recQ-mediated genome instability protein 2 K15365 RMI2; RecQ-mediated genome instability protein 2
D RPA (replication factor A)
E 117533891 rpa1; replication protein A 70 kDa DNA-binding subunit K07466 RFA1; replication factor A1
E 117534433 replication protein A 70 kDa DNA-binding subunit-like isoform X1 K07466 RFA1; replication factor A1
E 117557341 LOW QUALITY PROTEIN: replication protein A 32 kDa subunit-like K10739 RFA2; replication factor A2
E 117557681 replication protein A 32 kDa subunit-like K10739 RFA2; replication factor A2
E 117559994 replication protein A 32 kDa subunit-like K10739 RFA2; replication factor A2
E 117558048 rpa3; replication protein A 14 kDa subunit K10740 RPA3; replication factor A3
D Protein phosphatase 4
E 117549535 serine/threonine-protein phosphatase 4 catalytic subunit B K15423 PPP4C; serine/threonine-protein phosphatase 4 catalytic subunit [EC:3.1.3.16]
E 117539502 ppp4r1l; serine/threonine-protein phosphatase 4 regulatory subunit 1 K15424 PPP4R1; serine/threonine-protein phosphatase 4 regulatory subunit 1
E 117538694 ppp4r2b; serine/threonine-protein phosphatase 4 regulatory subunit 2-B isoform X1 K15425 PPP4R2; serine/threonine-protein phosphatase 4 regulatory subunit 2
E 117543078 serine/threonine-protein phosphatase 4 regulatory subunit 2-A-like isoform X1 K15425 PPP4R2; serine/threonine-protein phosphatase 4 regulatory subunit 2
E 117556045 smek1; serine/threonine-protein phosphatase 4 regulatory subunit 3 isoform X1 K17491 SMEK; protein phosphatase 4 regulatory subunit 3
E 117560777 ppp4r3b; serine/threonine-protein phosphatase 4 regulatory subunit 3B isoform X1 K17491 SMEK; protein phosphatase 4 regulatory subunit 3
D AP-5 complex
E 117532958 ap5b1; AP-5 complex subunit beta-1 K19022 AP5B1; AP-5 complex subunit beta-1
E 117549920 ap5m1; AP-5 complex subunit mu-1 K19023 AP5M1; AP-5 complex subunit mu-1
E 117558821 ap5s1; AP-5 complex subunit sigma-1 K19024 AP5S1; AP-5 complex subunit sigma-1
E 117560372 ap5z1; AP-5 complex subunit zeta-1 isoform X1 K19025 AP5Z1; AP-5 complex subunit zeta-1
D SMC5-SMC6 complex
E 117541933 smc5; LOW QUALITY PROTEIN: structural maintenance of chromosomes protein 5 K22803 SMC5; structural maintenance of chromosomes protein 5
E 117537507 structural maintenance of chromosomes protein 6-like K22804 SMC6; structural maintenance of chromosomes protein 6
E 117533766 LOW QUALITY PROTEIN: structural maintenance of chromosomes protein 6-like K22804 SMC6; structural maintenance of chromosomes protein 6
E 117542159 structural maintenance of chromosomes protein 6-like K22804 SMC6; structural maintenance of chromosomes protein 6
E 117542947 smc6; structural maintenance of chromosomes protein 6 K22804 SMC6; structural maintenance of chromosomes protein 6
E 117558071 lratd1; protein LRATD1 K22805 FAM84A; protein FAM84A
E 117561599 nsmce1; non-structural maintenance of chromosomes element 1 homolog K22817 NSMCE1; non-structural maintenance of chromosomes element 1 [EC:2.3.2.27]
E 117537481 nsmce2; E3 SUMO-protein ligase NSE2 K22756 NSMCE2; E3 SUMO-protein ligase NSE2 [EC:2.3.2.-]
E 117535213 ndnl2; necdin-like 2 K22823 NSMCE3; non-structural maintenance of chromosomes element 3
E 117552880 LOW QUALITY PROTEIN: non-structural maintenance of chromosomes element 4 homolog A-like K22825 NSMCE4; non-structural maintenance of chromosomes element 4
E 117552889 non-structural maintenance of chromosomes element 4 homolog A-like K22825 NSMCE4; non-structural maintenance of chromosomes element 4
E 117543988 slf1; LOW QUALITY PROTEIN: SMC5-SMC6 complex localization factor protein 1 K26126 SLF1; SMC5-SMC6 complex localization factor protein 1
E 117538241 slf2; SMC5-SMC6 complex localization factor protein 2 isoform X1 K26127 SLF2; SMC5-SMC6 complex localization factor protein 2
D Other HR factors
E 117533408 LOW QUALITY PROTEIN: crossover junction endonuclease EME1-like K10882 EME1; crossover junction endonuclease EME1 [EC:3.1.22.-]
E 117556756 exd2; exonuclease 3'-5' domain-containing protein 2 isoform X1 K20777 EXD2; exonuclease 3'-5' domain-containing protein 2 [EC:3.1.11.1]
E 117550343 crossover junction endonuclease MUS81-like K08991 MUS81; crossover junction endonuclease MUS81 [EC:3.1.22.-]
E 117556907 crossover junction endonuclease MUS81-like K08991 MUS81; crossover junction endonuclease MUS81 [EC:3.1.22.-]
E 117551889 crossover junction endonuclease MUS81-like K08991 MUS81; crossover junction endonuclease MUS81 [EC:3.1.22.-]
E 117551890 crossover junction endonuclease MUS81-like isoform X1 K08991 MUS81; crossover junction endonuclease MUS81 [EC:3.1.22.-]
E 117559387 crossover junction endonuclease MUS81-like K08991 MUS81; crossover junction endonuclease MUS81 [EC:3.1.22.-]
E 117559397 crossover junction endonuclease MUS81-like K08991 MUS81; crossover junction endonuclease MUS81 [EC:3.1.22.-]
E 117562847 sem1; 26S proteasome complex subunit SEM1 K10881 SHFM1; 26 proteasome complex subunit DSS1
E 117534098 swi5; DNA repair protein SWI5 homolog K10991 SWI5; DNA repair protein Swi5/Sae3
E 117544292 swi5-dependent recombination DNA repair protein 1 homolog K10992 SFR1; Swi5-dependent recombination DNA repair protein 1
E 117560754 swi5-dependent recombination DNA repair protein 1 homolog K10992 SFR1; Swi5-dependent recombination DNA repair protein 1
E 117551796 slx1b; structure-specific endonuclease subunit SLX1 isoform X1 K15078 SLX1; structure-specific endonuclease subunit SLX1 [EC:3.6.1.-]
E 117561608 slx4; structure-specific endonuclease subunit SLX4 isoform X1 K10484 BTBD12; structure-specific endonuclease subunit SLX4 (BTB/POZ domain-containing protein 12)
E 117555893 flap endonuclease GEN homolog 1 K15338 GEN1; holliday junction resolvase GEN1/YEN1 [EC:3.1.-.-]
E 117532954 LOW QUALITY PROTEIN: spatacsin-like K19026 SPG11; spatacsin
E 117557530 zfyve26; LOW QUALITY PROTEIN: zinc finger FYVE domain-containing protein 26 K19027 ZFYVE26; zinc finger FYVE domain-containing protein 26
E 117559179 rad51ap1; RAD51-associated protein 1 isoform X1 K20778 RAD51AP1; RAD51-associated protein 1
E 117538829 morf4l1; mortality factor 4-like protein 1 isoform X1 K11339 MORF4L1; mortality factor 4-like protein 1
E 117549349 mortality factor 4-like protein 1 isoform X1 K11339 MORF4L1; mortality factor 4-like protein 1
E 117540696 deoxynucleoside triphosphate triphosphohydrolase SAMHD1-like isoform X1 K22544 SAMHD1; deoxynucleoside triphosphate triphosphohydrolase SAMHD1 [EC:3.1.5.-]
E 117540736 samhd1; deoxynucleoside triphosphate triphosphohydrolase SAMHD1 K22544 SAMHD1; deoxynucleoside triphosphate triphosphohydrolase SAMHD1 [EC:3.1.5.-]
E 117540737 deoxynucleoside triphosphate triphosphohydrolase SAMHD1-like isoform X1 K22544 SAMHD1; deoxynucleoside triphosphate triphosphohydrolase SAMHD1 [EC:3.1.5.-]
E 117540739 LOW QUALITY PROTEIN: deoxynucleoside triphosphate triphosphohydrolase SAMHD1-like K22544 SAMHD1; deoxynucleoside triphosphate triphosphohydrolase SAMHD1 [EC:3.1.5.-]
E 117552067 fignl1; fidgetin-like protein 1 K22766 FIGNL1; fidgetin-like protein 1 [EC:5.6.2.-]
E 117558378 spidr; DNA repair-scaffolding protein isoform X1 K22806 SPIDR; DNA repair-scaffolding protein
E 117537434 lratd2b; protein LRATD2 K22810 FAM84B; protein FAM84B
E 117562842 lratd2a; protein LRATD2a K22810 FAM84B; protein FAM84B
E 117556122 brat1; BRCA1-associated ATM activator 1 isoform X1 K23112 BRAT1; BRCA1-associated ATM activator 1
E 117556642 cfap410; cilia- and flagella-associated protein 410 isoform X1 K23456 CFAP410; cilla- and flagella-associated protein
E 117550978 hdgfl2; hepatoma-derived growth factor-related protein 2 isoform X1 K25065 HDGFL2; hepatoma-derived growth factor-related protein 2
E 117557249 zswim7; zinc finger SWIM domain-containing protein 7 K25770 ZSWIM7; zinc finger SWIM domain-containing protein 7
E 117551369 swsap1; ATPase SWSAP1 K25771 SWSAP1; ATPase SWSAP1
E 117551211 emsy; BRCA2-interacting transcriptional repressor EMSY isoform X1 K25790 EMSY; BRCA2-interacting transcriptional repressor EMSY
E 117539367 hsf2bp; heat shock factor 2-binding protein K25791 HSF2BP; heat shock factor 2-binding protein
E 117554685 mms22l; LOW QUALITY PROTEIN: protein MMS22-like K26125 MMS22L; protein MMS22-like
E 117549801 tonsl; tonsoku-like protein isoform X1 K09257 NFKBIL2; NF-kappa-B inhibitor-like protein 2
E 117552488 parpbp; PCNA-interacting partner isoform X1 K27412 PARPBP; PCNA-interacting partner
C NHEJ (non-homologous end-joining)
D DNA-PK complex
E 117536234 xrcc6; X-ray repair cross-complementing protein 6 K10884 XRCC6; ATP-dependent DNA helicase 2 subunit 1
E 117556832 xrcc5; X-ray repair cross-complementing protein 5 K10885 XRCC5; ATP-dependent DNA helicase 2 subunit 2
E 117543627 prkdc; LOW QUALITY PROTEIN: DNA-dependent protein kinase catalytic subunit K06642 PRKDC; DNA-dependent protein kinase catalytic subunit [EC:2.7.11.1]
D MRX complex
E 117552207 mre11a; double-strand break repair protein MRE11 K10865 MRE11; double-strand break repair protein MRE11
E 117540204 rad50; DNA repair protein RAD50 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
D DNA Ligase 4 complex
E 117546558 lig4; DNA ligase 4 K10777 LIG4; DNA ligase 4 [EC:6.5.1.1]
E 117536695 DNA repair protein XRCC4-like isoform X1 K10886 XRCC4; DNA-repair protein XRCC4
E 117535347 DNA repair protein XRCC4-like K10886 XRCC4; DNA-repair protein XRCC4
D X-family DNA polymerases
E 117561600 poll; DNA polymerase lambda isoform X1 K03512 POLL; DNA polymerase lambda [EC:2.7.7.7 4.2.99.-]
E 117551339 polm; DNA-directed DNA/RNA polymerase mu K03513 POLM; DNA polymerase mu [EC:2.7.7.7]
E 117551139 dntt; DNA nucleotidylexotransferase K00977 DNTT; DNA nucleotidylexotransferase [EC:2.7.7.31]
E 117560525 polb; DNA polymerase beta K02330 POLB; DNA polymerase beta [EC:2.7.7.7 4.2.99.-]
D Other NHEJ factors
E 117561997 aptx; aprataxin isoform X1 K10863 APTX; aprataxin [EC:3.6.1.70 3.6.1.71 3.6.1.72]
E 117551936 aplf; aprataxin and PNK-like factor isoform X1 K13295 APLF; aprataxin and PNK-like factor [EC:3.1.-.-]
E 117552435 dclre1c; protein artemis K10887 DCLRE1C; DNA cross-link repair 1C protein [EC:3.1.-.-]
E 117534373 tdp2b; tyrosyl-DNA phosphodiesterase 2 isoform X1 K19619 TDP2; tyrosyl-DNA phosphodiesterase 2 [EC:3.1.4.-]
E 117544703 smchd1; structural maintenance of chromosomes flexible hinge domain-containing protein 1 isoform X1 K23113 SMCHD1; structural maintenance of chromosomes flexible hinge domain-containing protein 1
E 117551455 si:dkey-127k13.1; PWWP domain-containing DNA repair factor 3B isoform X1 K23386 PWWP3; PWWP domain-containing DNA repair factor 3
E 117541210 paxx; protein PAXX isoform X1 K25772 PAXX; protein PAXX
E 117545773 si:ch211-127m7.2; DNA ligase 1 K26155 CYREN; cell cycle regulator of non-homologous end joining
E 117539814 jmjd8; jmjC domain-containing protein 8 K25792 JMJD8; jumonji domain-containing protein 8
E 117555676 shld2; shieldin complex subunit 2 isoform X1 K26129 SHLD2; shieldin complex subunit 2
E 117535023 zgc:101664; shieldin complex subunit 3 isoform X1 K26130 SHLD3; shieldin complex subunit 3
C FA (Fanconi anemia) pathway
D FA core complex
E 117539067 LOW QUALITY PROTEIN: Fanconi anemia group A protein-like K10888 FANCA; fanconi anemia group A protein
E 117544343 fancb; LOW QUALITY PROTEIN: Fanconi anemia group B protein K10889 FANCB; fanconi anemia group B protein
E 117558567 fancc; LOW QUALITY PROTEIN: Fanconi anemia group C protein K10890 FANCC; fanconi anemia group C protein
E 117541747 fance; Fanconi anemia group E protein isoform X1 K10892 FANCE; fanconi anemia group E protein
E 117538809 fancf; Fanconi anemia group F protein K10893 FANCF; fanconi anemia group F protein
E 117546210 fancg; Fanconi anemia group G protein isoform X1 K10894 FANCG; fanconi anemia group G protein
E 117551380 fancl; E3 ubiquitin-protein ligase FANCL isoform X1 K10606 FANCL; E3 ubiquitin-protein ligase FANCL [EC:2.3.2.27]
E 117556415 fancm; Fanconi anemia group M protein isoform X1 K10896 FANCM; fanconi anemia group M protein
E 117546550 faap24; Fanconi anemia core complex-associated protein 24 K10898 FAAP24; fanconi anemia-associated protein
E 117545150 faap100; Fanconi anemia core complex-associated protein 100 K10993 FAAP100; fanconi anemia core complex 100 kDa subunit
D FA core complex binding factors
E 117545502 transcription factor HES-1-like K06054 HES1; hairy and enhancer of split 1
E 117547187 her6; hairy-related 6 K06054 HES1; hairy and enhancer of split 1
E 117541940 her9; hairy-related 9 isoform X1 K06054 HES1; hairy and enhancer of split 1
E 117548122 cenps; centromere protein S K11511 APITD1; centromere protein S
E 117548306 cenpx; centromere protein X K15360 STRA13; centromere protein X
E 117542096 ube2t; ubiquitin-conjugating enzyme E2 T K13960 UBE2T; ubiquitin-conjugating enzyme E2 T [EC:2.3.2.23]
D Bloom's syndrome complex (BTR)
E 117557659 blm; Bloom syndrome protein homolog isoform X1 K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 117541217 top3b; DNA topoisomerase 3-beta-1 isoform X1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 117534937 top3a; DNA topoisomerase 3-alpha isoform X1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 117558636 rmi1; recQ-mediated genome instability protein 1 K10990 RMI1; RecQ-mediated genome instability protein 1
E 117548695 rmi2; LOW QUALITY PROTEIN: recQ-mediated genome instability protein 2 K15365 RMI2; RecQ-mediated genome instability protein 2
D FANCD2-I complex
E 117551159 fancd2; Fanconi anemia group D2 protein K10891 FANCD2; fanconi anemia group D2 protein
E 117545711 fanci; Fanconi anemia group I protein isoform X1 K10895 FANCI; fanconi anemia group I protein
D Downstream FA components
E 117544825 breast cancer type 1 susceptibility protein homolog isoform X1 K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 117540448 brca2; breast cancer type 2 susceptibility protein isoform X1 K08775 BRCA2; breast cancer 2 susceptibility protein
E 117556319 brip1; Fanconi anemia group J protein isoform X1 K15362 BRIP1; fanconi anemia group J protein [EC:5.6.2.3]
D Other FA pathway factors
E 117538860 fan1; fanconi-associated nuclease 1 K15363 FAN1; fanconi-associated nuclease 1 [EC:3.1.21.- 3.1.4.1]
E 117538642 rad51; DNA repair protein RAD51 homolog 1 isoform X1 K04482 RAD51; DNA repair protein RAD51
E 117559423 rad51c; DNA repair protein RAD51 homolog 3 isoform X1 K10870 RAD51L2; RAD51-like protein 2
E 117545066 telo2; telomere length regulation protein TEL2 homolog K11137 TELO2; telomere length regulation protein
E 117542898 usp1; ubiquitin carboxyl-terminal hydrolase 1 isoform X1 K11832 USP1; ubiquitin carboxyl-terminal hydrolase 1 [EC:3.4.19.12]
E 117556653 WD repeat-containing protein 48 isoform X1 K15361 WDR48; WD repeat-containing protein 48
C Other DSBR factors
D Protein phosphatase 6
E 117547300 serine/threonine-protein phosphatase 6 catalytic subunit-like K15498 PPP6C; serine/threonine-protein phosphatase 6 catalytic subunit [EC:3.1.3.16]
E 117558614 serine/threonine-protein phosphatase 6 catalytic subunit K15498 PPP6C; serine/threonine-protein phosphatase 6 catalytic subunit [EC:3.1.3.16]
E 117557648 ppp6r2b; serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X1 K15500 PPP6R2; serine/threonine-protein phosphatase 6 regulatory subunit 2
E 117553142 ppp6r2a; serine/threonine-protein phosphatase 6 regulatory subunit 2a isoform X1 K15500 PPP6R2; serine/threonine-protein phosphatase 6 regulatory subunit 2
E 117532717 ppp6r3; serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X1 K15501 PPP6R3; serine/threonine-protein phosphatase 6 regulatory subunit 3
E 117554123 ankrd28b; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A K15502 ANKRD28; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A
E 117562977 LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A K15502 ANKRD28; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A
E 117536048 LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B-like K15503 ANKRD44; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B
E 117534051 serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C-like isoform X1 K15504 ANKRD52; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C
E 117534235 serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C-like K15504 ANKRD52; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C
D Ubiquitin ligases
E 117562317 rnf8; E3 ubiquitin-protein ligase rnf8 isoform X1 K10667 RNF8; E3 ubiquitin-protein ligase RNF8 [EC:2.3.2.27]
E 117535271 rnf168; E3 ubiquitin-protein ligase rnf168 K20779 RNF168; E3 ubiquitin-protein ligase RNF168 [EC:2.3.2.31]
E 117546810 herc2; LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase HERC2 K10595 HERC2; E3 ubiquitin-protein ligase HERC2 [EC:2.3.2.26]
D Others
E 117549012 wrap53; telomerase Cajal body protein 1 K23314 WRAP53; telomerase Cajal body protein 1
E 117558799 tprn; taperin K24164 TPRN; taperin
E 117541388 WD repeat-containing protein 70 K24752 WDR70; WD repeat-containing protein 70
E 117533011 WD repeat-containing protein 76-like isoform X1 K24755 WDR76; WD repeat-containing protein 76
E 117533013 wdr76; WD repeat-containing protein 76 isoform X1 K24755 WDR76; WD repeat-containing protein 76
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
D 117560871 polh; DNA polymerase eta K03509 POLH; DNA polymerase eta [EC:2.7.7.7]
D 117552034 poli; DNA polymerase iota isoform X1 K03510 POLI; DNA polymerase iota [EC:2.7.7.7]
D 117536714 polk; DNA polymerase kappa K03511 POLK; DNA polymerase kappa [EC:2.7.7.7]
D 117544607 rev1; LOW QUALITY PROTEIN: DNA repair protein REV1 K03515 REV1; DNA repair protein REV1 [EC:2.7.7.-]
C B-family DNA polymerases
D 117557152 rev3l; DNA polymerase zeta catalytic subunit K02350 REV3L; DNA polymerase zeta [EC:2.7.7.7]
C A-family DNA polymerase
D 117539188 poln; DNA polymerase nu K16618 POLN; DNA polymerase nu [EC:2.7.7.7]
C Rad6 epistasis group
D 117543469 ubiquitin-conjugating enzyme E2 A K10573 UBE2A; ubiquitin-conjugating enzyme E2 A [EC:2.3.2.23]
D 117556842 ube2al; ubiquitin conjugating enzyme E2 A, like K10573 UBE2A; ubiquitin-conjugating enzyme E2 A [EC:2.3.2.23]
D 117540201 ube2b; ubiquitin-conjugating enzyme E2 B isoform X1 K10574 UBE2B; ubiquitin-conjugating enzyme E2 B [EC:2.3.2.23]
D 117551171 rad18; E3 ubiquitin-protein ligase RAD18 isoform X1 K10627 RAD18; E3 ubiquitin-protein ligase RAD18 [EC:2.3.2.27]
D 117539563 hltf; helicase-like transcription factor K15711 SMARCA3; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A3 [EC:5.6.2. 2.3.2.27]
D 117549107 ubiquitin-conjugating enzyme E2 variant 1-like K10704 UBE2V; ubiquitin-conjugating enzyme E2 variant
D 117558460 ube2v2; ubiquitin-conjugating enzyme E2 variant 2 K10704 UBE2V; ubiquitin-conjugating enzyme E2 variant
D 117545719 ube2na; ubiquitin-conjugating enzyme E2Na K10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23]
D 117535970 ube2nb; ubiquitin-conjugating enzyme E2Nb K10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23]
C Other TLS factors
D 117561313 pcna; proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
D 117552488 parpbp; PCNA-interacting partner isoform X1 K27412 PARPBP; PCNA-interacting partner
D 117535651 sprT-like domain-containing protein Spartan K24051 SPRTN; SprT-like domain-contaning protein Spartan
D 117556939 gcna; acidic repeat-containing protein K26957 GCNA; germ cell nuclear acidic protein
B Check point factors
C Rad9-Hus1-Rad1 complex
D 117555880 rad9a; cell cycle checkpoint control protein RAD9A K10994 RAD9A; cell cycle checkpoint control protein RAD9A [EC:3.1.11.2]
D 117539059 rad9b; cell cycle checkpoint control protein RAD9B K10995 RAD9B; cell cycle checkpoint control protein RAD9B
D 117538917 rad1; LOW QUALITY PROTEIN: cell cycle checkpoint protein RAD1 K02830 HRAD1; cell cycle checkpoint protein [EC:3.1.11.2]
C HRAD17(Rad24)-RFC complex
D 117534973 rad17; cell cycle checkpoint protein RAD17 isoform X1 K06662 HRAD17; cell cycle checkpoint protein
D 117541477 rfc2; replication factor C subunit 2 K10755 RFC2_4; replication factor C subunit 2/4
D 117558990 rfc4; replication factor C subunit 4 K10755 RFC2_4; replication factor C subunit 2/4
D 117552112 rfc5; replication factor C subunit 5 K10756 RFC3_5; replication factor C subunit 3/5
D 117540589 rfc3; replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
C Rad17-Mec3-Ddc1 complex
D 117538917 rad1; LOW QUALITY PROTEIN: cell cycle checkpoint protein RAD1 K02830 HRAD1; cell cycle checkpoint protein [EC:3.1.11.2]
C FPC (fork protection complex)
D 117534169 timeless; protein timeless homolog K10997 TIMELESS; replication fork protection complex subunit TIMELESS/Tof1/Swi1
D 117557823 tipin; TIMELESS-interacting protein isoform X1 K10998 TIPIN; replication fork protection complex subunit TIPIN/Csm3/Swi3
D 117545400 claspin isoform X1 K25773 CLSPN; claspin
C Triple T complex
D 117545066 telo2; telomere length regulation protein TEL2 homolog K11137 TELO2; telomere length regulation protein
D 117532854 tti1; TELO2-interacting protein 1 homolog K20403 TTI1; TELO2-interacting protein 1
D 117535008 tti2; TELO2-interacting protein 2 K23115 TTI2; TELO2-interacting protein 2
C BAG6-UBL4A-GET4 complex
D 117543217 large proline-rich protein BAG6-like isoform X1 K23390 BAG6; large proline-rich protein BAG6
D 117561141 ubl4a; ubiquitin-like protein 4A K23388 UBL4; ubiquitin-like protein 4
D 117563104 get4; Golgi to ER traffic protein 4 homolog K23387 GET4; golgi to ER traffic protein 4
C Other check point factors
D 117558768 atr; LOW QUALITY PROTEIN: serine/threonine-protein kinase ATR K06640 ATR; serine/threonine-protein kinase ATR [EC:2.7.11.1]
D 117539434 atrip; LOW QUALITY PROTEIN: ATR-interacting protein K10905 ATRIP; ATR interacting protein
D 117551661 atm; serine-protein kinase ATM isoform X1 K04728 ATM; serine-protein kinase ATM [EC:2.7.11.1]
D 117552767 tp53; cellular tumor antigen p53 K04451 TP53; tumor protein p53
D 117535558 chek1; LOW QUALITY PROTEIN: serine/threonine-protein kinase Chk1 K02216 CHEK1; serine/threonine-protein kinase CHEK1 [EC:2.7.11.1]
D 117562423 chek2; serine/threonine-protein kinase Chk2 K06641 CHEK2; serine/threonine-protein kinase CHEK2 [EC:2.7.11.1]
D 117558914 cdc25b; M-phase inducer phosphatase 2 isoform X1 K05866 CDC25B; M-phase inducer phosphatase 2 [EC:3.1.3.48]
D 117551545 14-3-3-like protein K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
D 117540757 14-3-3 protein beta/alpha-1 K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
D 117536172 ywhaz; 14-3-3 protein zeta/delta K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
D 117549969 14-3-3 protein beta/alpha-like K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
D 117556355 ywhaba; 14-3-3 protein beta/alpha-A K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
D 117557281 ywhag1; 14-3-3 protein gamma-1 K16198 YWHAG_H; 14-3-3 protein gamma/eta
D 117540403 ywhag2; 14-3-3 protein gamma-2 K16198 YWHAG_H; 14-3-3 protein gamma/eta
D 117533367 LOW QUALITY PROTEIN: 14-3-3 protein epsilon-like K06630 YWHAE; 14-3-3 protein epsilon
D 117543026 14-3-3 protein epsilon-like K06630 YWHAE; 14-3-3 protein epsilon
D 117549434 nav2a; neuron navigator 2 isoform X1 K19483 NAV2; neuron navigator 2 [EC:5.6.2.4]
D 117550831 wee2; wee1-like protein kinase 2 K06632 WEE1; wee1-like protein kinase [EC:2.7.11.1]
D 117554972 wee1; LOW QUALITY PROTEIN: wee1-like protein kinase K06632 WEE1; wee1-like protein kinase [EC:2.7.11.1]
D 117552721 per1b; period circadian protein homolog 1b isoform X1 K21944 PER1; period circadian protein 1
D 117558380 per2; LOW QUALITY PROTEIN: period circadian protein homolog 2 K02633 PER2; period circadian protein 2
D 117549588 mdc1; LOW QUALITY PROTEIN: mediator of DNA damage checkpoint protein 1 K20780 MDC1; mediator of DNA damage checkpoint protein 1
D 117538464 pls3; plastin-3 K17336 PLS3; plastin-3
D 117536411 plastin-3-like isoform X1 K17336 PLS3; plastin-3
D 117559116 isg20; apoptosis-enhancing nuclease K18340 AEN; apoptosis-enhancing nuclease [EC:3.1.-.-]
D 117558469 plk3; serine/threonine-protein kinase PLK3 K08862 PLK3; polo-like kinase 3 [EC:2.7.11.21]
D 117553418 nek1; LOW QUALITY PROTEIN: serine/threonine-protein kinase Nek1 K08857 NEK1_4_5; serine/threonine-protein kinase Nek1/4/5 [EC:2.7.11.1]
D 117547543 nek4; serine/threonine-protein kinase Nek4 isoform X1 K08857 NEK1_4_5; serine/threonine-protein kinase Nek1/4/5 [EC:2.7.11.1]
D 117543185 nek10; serine/threonine-protein kinase Nek10 isoform X1 K20879 NEK10; serine/threonine-protein kinase Nek10 [EC:2.7.11.1]
D 117546613 LOW QUALITY PROTEIN: protein downstream neighbor of son homolog K22422 DONSON; protein downstream neighbor of Son
D 117544243 kank3; LOW QUALITY PROTEIN: KN motif and ankyrin repeat domain-containing protein 3 K22808 KANK; KN motif and ankyrin repeat domain-containing protein
D 117545480 KN motif and ankyrin repeat domain-containing protein 4-like K22808 KANK; KN motif and ankyrin repeat domain-containing protein
D 117546456 kank1a; KN motif and ankyrin repeat domain-containing protein 1a isoform X1 K22808 KANK; KN motif and ankyrin repeat domain-containing protein
D 117548850 kank2; LOW QUALITY PROTEIN: KN motif and ankyrin repeat domain-containing protein 2 K22808 KANK; KN motif and ankyrin repeat domain-containing protein
D 117542920 kank4; microtubule-associated protein futsch K22808 KANK; KN motif and ankyrin repeat domain-containing protein
D 117561483 KN motif and ankyrin repeat domain-containing protein 1-like isoform X1 K22808 KANK; KN motif and ankyrin repeat domain-containing protein
D 117560041 chmp4c; LOW QUALITY PROTEIN: charged multivesicular body protein 4c K24782 CHMP4C; charged multivesicular body protein 4C
D 117553220 vps4a; vacuolar protein sorting-associated protein 4A K12196 VPS4; vacuolar protein-sorting-associated protein 4
D 117555138 vacuolar protein sorting-associated protein 4B-like K12196 VPS4; vacuolar protein-sorting-associated protein 4
D 117558427 vps4b; vacuolar protein sorting-associated protein 4B isoform X1 K12196 VPS4; vacuolar protein-sorting-associated protein 4
D 117549892 zfyve19; abscission/NoCut checkpoint regulator isoform X1 K24778 ZFYVE19; abscission/NoCut checkpoint regulator
B Other factors with a suspected DNA repair function
C DNA polymerases
D 117543414 polq; LOW QUALITY PROTEIN: DNA polymerase theta K02349 POLQ; DNA polymerase theta [EC:2.7.7.7]
D 117548961 mybbp1a; myb-binding protein 1A-like protein K02331 POL5; DNA polymerase phi [EC:2.7.7.7]
D 117537752 primpol; DNA-directed primase/polymerase protein isoform X1 K22761 PRIMPOL; DNA-directed primase/polymerase protein [EC:2.7.7.102 2.7.7.7]
C Nucleases
D 117544915 dclre1a; DNA cross-link repair 1A protein K15340 DCLRE1A; DNA cross-link repair 1A protein
D 117541903 5' exonuclease Apollo-like K15341 DCLRE1B; DNA cross-link repair 1B protein [EC:3.1.-.-]
D 117541904 5' exonuclease Apollo-like K15341 DCLRE1B; DNA cross-link repair 1B protein [EC:3.1.-.-]
D 117562548 endonuclease V-like K21813 ENDOV; endonuclease V [EC:3.1.26.-]
D 117562713 zranb3; DNA annealing helicase and endonuclease ZRANB3 K25861 ZRANB3; DNA annealing helicase and endonuclease ZRANB3 [EC:5.6.2.- 3.1.-.-]
D 117544282 ankle1; ankyrin repeat and LEM domain-containing protein 1 K21411 ANKLE1; ankyrin repeat and LEM domain-containing protein 1
C Helicases
D 117558662 ercc6l2; DNA excision repair protein ERCC-6-like 2 isoform X1 K20098 ERCC6L2; DNA excision repair protein ERCC-6-like 2 [EC:5.6.2.-]
C PSO4 complex
D 117555937 prpf19; pre-mRNA-processing factor 19 K10599 PRPF19; pre-mRNA-processing factor 19 [EC:2.3.2.27]
D 117542143 cdc5l; cell division cycle 5-like protein K12860 CDC5L; pre-mRNA-splicing factor CDC5/CEF1
D 117532809 bcas2; pre-mRNA-splicing factor SPF27 K12861 BCAS2; pre-mRNA-splicing factor SPF27
D 117556072 plrg1; pleiotropic regulator 1 K12862 PLRG1; pleiotropic regulator 1
C Modulation of nucleotide pools
D 117546579 nudt15; nucleotide triphosphate diphosphatase NUDT15 K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D 117548622 nudt1; 7,8-dihydro-8-oxoguanine triphosphatase K17816 NUDT1; 8-oxo-dGTP diphosphatase / 2-hydroxy-dATP diphosphatase [EC:3.6.1.55 3.6.1.56]
D 117535016 nudt18; 8-oxo-dGDP phosphatase NUDT18 isoform X1 K17817 NUDT18; 8-oxo-dGDP phosphatase [EC:3.6.1.58]
D 117549258 dut; deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial isoform X1 K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 117538480 LOW QUALITY PROTEIN: ribonucleoside-diphosphate reductase large subunit-like K10807 RRM1; ribonucleoside-diphosphate reductase subunit M1 [EC:1.17.4.1]
D 117552128 ribonucleoside-diphosphate reductase large subunit K10807 RRM1; ribonucleoside-diphosphate reductase subunit M1 [EC:1.17.4.1]
D 117551829 ribonucleoside-diphosphate reductase subunit M2 isoform X1 K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]
D 117536156 rrm2b; ribonucleoside-diphosphate reductase subunit M2 B K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]
#
AProkaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D 117560919 mgmt; LOW QUALITY PROTEIN: methylated-DNA--protein-cysteine methyltransferase K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
D 117545581 deoxyribodipyrimidine photo-lyase-like K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]
D 117545582 deoxyribodipyrimidine photo-lyase-like isoform X1 K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]
C BER (base exicision repair)
D DNA glycosylases
E 117561060 unga; uracil DNA glycosylase a K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E 117554879 smug1; single-strand selective monofunctional uracil DNA glycosylase K10800 SMUG1; single-strand selective monofunctional uracil DNA glycosylase [EC:3.2.2.-]
E 117548619 mpg; LOW QUALITY PROTEIN: DNA-3-methyladenine glycosylase K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]
E 117550892 mutyh; adenine DNA glycosylase isoform X1 K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
E 117561621 nthl1; endonuclease III-like protein 1 isoform X1 K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
D RecJ
D DNA ligase
D DNA polymerase I
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase complex (RNAP)
E TRCF (transcription-repair coupling factor)
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
D Molecular matchmaker
D Strand discrimination factor
D DNA exonucleases
D DNA polymerase III holoenzyme
D DNA ligase
D Other MMR factors
E 117552451 ssbp1; single-stranded DNA-binding protein, mitochondrial K03111 ssb; single-strand DNA-binding protein
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D RecBC pathway proteins
D RecFOR pathway proteins
D AddAB pathway proteins
D Other HR factor
D Archaeal homologous recombinant proteins
C NHEJ (non-homologous end-joining)
D Two-component NHEJ DNA repair complex
D SHIIR (short-homology-independent illegitimate recombination)
E Facilitator
E Supressor
D SHDIR (short-homology-dependent illegitimate recombination)
E RecET pathway
E Facilitator
E Supressor
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
C Other SOS response factors
D 117552451 ssbp1; single-stranded DNA-binding protein, mitochondrial K03111 ssb; single-strand DNA-binding protein
B Other factors with a suspected DNA repair function
C DNA polymerase
C DNA helicases
C Modulation of nucleotide pools
D 117546579 nudt15; nucleotide triphosphate diphosphatase NUDT15 K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D 117549258 dut; deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial isoform X1 K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
C Others
!
#
#[ BRITE | KEGG2 | KEGG ]
#Last updated: March 29, 2024