+D	Messenger RNA Biogenesis	KO
#<h2><a href="/kegg/brite.html"><img src="/Fig/bget/kegg3.gif" align="middle" border=0></a>&nbsp; Prokaryotic Defense System - Gemmatimonas groenlandica</h2>
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A<b>CRISPR-Cas system</b>
B  Universal Cas proteins
B  Type I CRISPR-Cas system
C    Type I signiture cas proteins
C    Subtype I-A factors
C    Subtype I-B factors
C    Subtype I-C factors
C    Subtype I-D factors
C    Subtype I-E factors
C    Subtype I-F factors
C    Subtype I-U factors
B  Type II CRISPR-Cas system
C    Type II signiture cas proteins
C    Subtype II-A factors
C    Subtype II-B factors
B  Type III CRISPR-Cas system
C    Type III signiture cas proteins
C    Subtype III-A factors
C    Subtype III-B factors
C    Subtype III-U factors
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A<b>Restriction and modification system (R-M system)</b>
B  Type I R-M system
C    HKW67_13910 hypothetical protein	K01154 hsdS; type I restriction enzyme, S subunit [EC:3.1.21.3] 
C    HKW67_13925 SAM-dependent DNA methyltransferase	K03427 hsdM; type I restriction enzyme M protein [EC:2.1.1.72] 
B  Type II R-M system
C    Restriction endonucleases
C    DNA methyltransferases
B  Type III R-M system
B  Type IV R-M system
C    HKW67_06700 DUF3427 domain-containing protein	K07451 mcrA; 5-methylcytosine-specific restriction enzyme A [EC:3.1.21.-] 
C    HKW67_06735 HNH endonuclease	K07451 mcrA; 5-methylcytosine-specific restriction enzyme A [EC:3.1.21.-] 
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A<b>Toxin-antitoxin system (TA system)</b>
B  Type I TA system
C    Hok-Sok
C    SymE-SymR
C    Ldr-Rdl
C    TisB-IstR
C    Ibs-Sib
C    ShoB-OhsC
C    RalR-RalA
B  Type II TA system
C    MazF-MazE
D      HKW67_02875 type II toxin-antitoxin system PemK/MazF family toxin	K07171 mazF; mRNA interferase MazF [EC:3.1.-.-] 
D      HKW67_12320 type II toxin-antitoxin system PemK/MazF family toxin	K07171 mazF; mRNA interferase MazF [EC:3.1.-.-] 
D      HKW67_02870 AbrB/MazE/SpoVT family DNA-binding domain-containing protein	K07172 mazE; antitoxin MazE 
C    ChpB-ChpS
C    YhaV-PrlF
C    RelE/StbE-RelB/StbD
C    YafQ-dinJ
C    YoeB-YefM
C    HipA-HipB
C    HicA-HicB
C    YafO-YafN
C    PspC-PspB
C    CcdB-CcdA
C    ParE-ParD
C    Doc-Phd
C    HigB-HigA
D      HKW67_13865 excinuclease ABC subunit A	K07334 higB-1; toxin HigB-1 
D      HKW67_13860 HigA family addiction module antidote protein	K21498 higA-1; antitoxin HigA-1 
D      HKW67_17395 HigA family addiction module antidote protein	K21498 higA-1; antitoxin HigA-1 
C    MqsR-MqsA
C    VapC-VapB
D      HKW67_13845 type II toxin-antitoxin system VapC family toxin	K28262 vapC7_13_23; ribonuclease VapC7/13/23 [EC:3.1.-.-] 
D      HKW67_13850 antitoxin	K28264 vapB13; antitoxin VapB13 
D      HKW67_00165 type II toxin-antitoxin system VapC family toxin	K28279 vapC22; ribonuclease VapC22 [EC:3.1.-.-] 
D      HKW67_21950 type II toxin-antitoxin system VapC family toxin	K28279 vapC22; ribonuclease VapC22 [EC:3.1.-.-] 
D      HKW67_00160 type II toxin-antitoxin system prevent-host-death family antitoxin	K28280 vapB22; antitoxin VapB22 
D      HKW67_21945 type II toxin-antitoxin system prevent-host-death family antitoxin	K28280 vapB22; antitoxin VapB22 
D      HKW67_02265 type II toxin-antitoxin system VapC family toxin	K28143 vapC24S; ribonuclease VapC24/25/29/31/33/37/38/39/41/43/44/48 [EC:3.1.-.-] 
D      HKW67_17610 PIN domain-containing protein	K28143 vapC24S; ribonuclease VapC24/25/29/31/33/37/38/39/41/43/44/48 [EC:3.1.-.-] 
D      HKW67_02260 hypothetical protein	K28144 vapB24S; antitoxin VapB24/25/29/31/33/37/38/39/41/43/44/48 
D      HKW67_17605 hypothetical protein	K28144 vapB24S; antitoxin VapB24/25/29/31/33/37/38/39/41/43/44/48 
D      HKW67_21065 hypothetical protein	K28144 vapB24S; antitoxin VapB24/25/29/31/33/37/38/39/41/43/44/48 
D      HKW67_21315 type II toxin-antitoxin system VapC family toxin	K19686 vapC28S; ribonuclease VapC28/30/34/36/42 [EC:3.1.-.-] 
D      HKW67_21310 type II toxin-antitoxin system VapB family antitoxin	K19687 vapB28S; antitoxin VapB28/30/34/36/42 
C    PezT-PezA
C    YobL-YobK
C    YokI-YokJ
C    YqcG-YqcF
C    YxiD-YxxD
C    FitB-FitA
C    BC_0920-BC_0921
C    SpoIISA-SpoIISB
C    Tse6-Tsi6
C    Type II TA system related factors
D      HKW67_07150 ftsZ; cell division protein FtsZ	K03531 ftsZ; cell division protein FtsZ 
D      HKW67_05230 rod shape-determining protein	K03569 mreB; rod shape-determining protein MreB and related proteins 
D      HKW67_04005 tRNA glutamyl-Q(34) synthetase GluQRS	K01885 EARS; glutamyl-tRNA synthetase [EC:6.1.1.17] 
D      HKW67_08060 glutamate--tRNA ligase	K01885 EARS; glutamyl-tRNA synthetase [EC:6.1.1.17] 
B  Type III TA system
C    AbiQ system
B  Type IV TA system
C    YeeV-YeeU
C    CptA-CptB
C    AbiEii-AbiEi
B  Type V TA system
C    GhoT-GhoS
C    Other GhoT/OrtT toxin family protein
B  Type VI TA system
C    SocB-SocA
B  Type VII TA system
C    Hha-TomB
C    TglT-TakA
C    HepT-MntA
B  Type VIII TA system
C    SdsR-RyeA
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A<b>DNA phosphothiolation system</b>
B  Sulfur modification proteins
C    HKW67_08975 cysteine desulfurase	K04487 iscS; cysteine desulfurase [EC:2.8.1.7] 
B  DNA phosphorothioation-dependent restriction proteins
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#Last updated: May 19, 2025