+E Replication protein KO
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DNA Replication Proteins - Homarus americanus (American lobster)
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AEukaryotic type
B DNA Replication Initiation Factors
C pre-RC (pre-replication complex)
D 121859711 origin recognition complex subunit 1-like K02603 ORC1; origin recognition complex subunit 1
D 121866015 origin recognition complex subunit 2-like K02604 ORC2; origin recognition complex subunit 2
D 121854956 origin recognition complex subunit 3-like K02605 ORC3; origin recognition complex subunit 3
D 121880410 origin recognition complex subunit 3-like K02605 ORC3; origin recognition complex subunit 3
D 121874924 origin recognition complex subunit 4-like isoform X1 K02606 ORC4; origin recognition complex subunit 4
D 121876448 origin recognition complex subunit 6-like K02608 ORC6; origin recognition complex subunit 6
D 121877189 DNA replication factor Cdt1-like isoform X1 K10727 CDT1; chromatin licensing and DNA replication factor 1
D 121871825 cell division control protein 6 homolog K02213 CDC6; cell division control protein 6
D 121875792 DNA replication licensing factor mcm2-like K02540 MCM2; DNA replication licensing factor MCM2 [EC:5.6.2.3]
D 121876349 zygotic DNA replication licensing factor mcm3-like K02541 MCM3; DNA replication licensing factor MCM3 [EC:5.6.2.3]
D 121877772 DNA replication licensing factor MCM4-like K02212 MCM4; DNA replication licensing factor MCM4 [EC:5.6.2.3]
D 121876239 DNA replication licensing factor Mcm5-like K02209 MCM5; DNA replication licensing factor MCM5 [EC:5.6.2.3]
D 121863155 zygotic DNA replication licensing factor mcm6-B-like K02542 MCM6; DNA replication licensing factor MCM6 [EC:5.6.2.3]
D 121859473 DNA replication licensing factor mcm7-like K02210 MCM7; DNA replication licensing factor MCM7 [EC:5.6.2.3]
C CDK (cyclin dependent kinase)
D 121867717 LOW QUALITY PROTEIN: G2/mitotic-specific cyclin-A-like K06627 CCNA; cyclin-A
D 121880154 G1/S-specific cyclin-E-like K06626 CCNE; G1/S-specific cyclin-E1
D 121865739 cyclin-dependent kinase 2-like K02206 CDK2; cyclin-dependent kinase 2 [EC:2.7.11.22]
C DDK (Dbf-4 dependent kinase)
D 121872234 uncharacterized protein LOC121872234 K02214 CDC7; cell division control protein 7 [EC:2.7.11.1]
C GINS complex
D 121857790 DNA replication complex GINS protein PSF1-like K10732 GINS1; GINS complex subunit 1
D 121870018 probable DNA replication complex GINS protein PSF2 K10733 GINS2; GINS complex subunit 2
D 121872568 DNA replication complex GINS protein PSF3-like K10734 GINS3; GINS complex subunit 3
D 121864189 DNA replication complex GINS protein SLD5-like K10735 GINS4; GINS complex subunit 4
C Other initiation factors
D 121876490 DNA topoisomerase 2-binding protein 1-like isoform X1 K10728 TOPBP1; topoisomerase (DNA) II binding protein 1
D 121866392 uncharacterized protein LOC121866392 K10730 RECQL4; ATP-dependent DNA helicase Q4 [EC:5.6.2.4]
D 121865673 cell division control protein 45 homolog K06628 CDC45; cell division control protein 45
D 121879018 DNA helicase MCM8-like K10737 MCM8; DNA helicase MCM8 [EC:5.6.2.4]
D 121871487 protein MCM10 homolog isoform X1 K10736 MCM10; minichromosome maintenance protein 10
D 121860343 mdm2-binding protein-like isoform X1 K26116 MTBP; Mdm2-binding protein
D 121863725 uncharacterized protein LOC121863725 K26117 TICRR; Treslin
B DNA Replication Elongation Factors
C DNA polymerase alpha / primase complex
D 121875639 DNA polymerase alpha catalytic subunit-like K02320 POLA1; DNA polymerase alpha subunit A [EC:2.7.7.7]
D 121863257 DNA polymerase alpha subunit B-like K02321 POLA2; DNA polymerase alpha subunit B
D 121862651 DNA primase small subunit-like K02684 PRI1; DNA primase small subunit [EC:2.7.7.102]
D 121861477 DNA primase large subunit-like K02685 PRI2; DNA primase large subunit
D 121872149 DNA primase large subunit-like K02685 PRI2; DNA primase large subunit
C DNA polymerase epsilon complex
D 121878021 DNA polymerase epsilon catalytic subunit A-like K02324 POLE; DNA polymerase epsilon subunit 1 [EC:2.7.7.7]
D 121867956 DNA polymerase epsilon subunit 2-like K02325 POLE2; DNA polymerase epsilon subunit 2 [EC:2.7.7.7]
D 121863238 DNA polymerase epsilon subunit 3-like K02326 POLE3; DNA polymerase epsilon subunit 3 [EC:2.7.7.7]
D 121879284 DNA polymerase epsilon subunit 4-like K03506 POLE4; DNA polymerase epsilon subunit 4 [EC:2.7.7.7]
C DNA polymerase delta complex
D 121863712 DNA polymerase delta catalytic subunit-like K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
D 121878793 DNA polymerase delta subunit 2-like K02328 POLD2; DNA polymerase delta subunit 2
D 121879954 DNA polymerase delta subunit 3-like K03504 POLD3; DNA polymerase delta subunit 3
C DNA polymerase gamma complex (mitochondrial)
D 121864022 DNA polymerase subunit gamma-1-like isoform X1 K02332 POLG; DNA polymerase gamma 1 [EC:2.7.7.7]
D 121860074 DNA polymerase subunit gamma-1-like K02332 POLG; DNA polymerase gamma 1 [EC:2.7.7.7]
C RPA (replication protein A)
D 121862910 replication protein A 70 kDa DNA-binding subunit-like K07466 RFA1; replication factor A1
D 121871392 replication protein A 32 kDa subunit-like K10739 RFA2; replication factor A2
D 121860752 uncharacterized protein LOC121860752 K10740 RPA3; replication factor A3
C RFC (replication factor C)
D 121855470 replication factor C subunit 1-like K10754 RFC1; replication factor C subunit 1
D 121861510 replication factor C subunit 2-like K10755 RFC2_4; replication factor C subunit 2/4
D 121871029 replication factor C subunit 4-like K10755 RFC2_4; replication factor C subunit 2/4
D 121873821 replication factor C subunit 5-like K10756 RFC3_5; replication factor C subunit 3/5
D 121874427 LOW QUALITY PROTEIN: replication factor C subunit 3-like K10756 RFC3_5; replication factor C subunit 3/5
C RNase H
D 121873231 ribonuclease H1-like isoform X1 K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
D 121870968 ribonuclease H2 subunit A-like isoform X1 K10743 RNASEH2A; ribonuclease H2 subunit A [EC:3.1.26.4]
D 121866985 ribonuclease H2 subunit B-like isoform X1 K10744 RNASEH2B; ribonuclease H2 subunit B
D 121869560 ribonuclease H2 subunit C-like K10745 RNASEH2C; ribonuclease H2 subunit C
C Other elongation factors
D 121868064 proliferating cell nuclear antigen-like K04802 PCNA; proliferating cell nuclear antigen
D 121867963 flap endonuclease 1-like K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
D 121873842 exonuclease 1-like isoform X1 K10746 EXO1; exonuclease 1 [EC:3.1.-.-]
D 121870130 DNA ligase 1-like isoform X1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
D 121856363 ATPase family AAA domain-containing protein 5-like isoform X1 K26118 ATAD5; ATPase family AAA domain-containing protein 5
B DNA Replication Termination Factors
C DNA methylation enzymes
D 121865192 DNA (cytosine-5)-methyltransferase PliMCI-like isoform X1 K00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]
D 121855737 DNA (cytosine-5)-methyltransferase 3A-like isoform X1 K17398 DNMT3A; DNA (cytosine-5)-methyltransferase 3A [EC:2.1.1.37]
C Prevention of re-replication factors
D 121860578 geminin-like K10749 GMNN; geminin
D 121877792 G2/mitotic-specific cyclin-B-like isoform X1 K05868 CCNB1; G2/mitotic-specific cyclin-B1
D 121863274 G2/mitotic-specific cyclin-B3-like isoform X1 K21771 CCNB3; G2/mitotic-specific cyclin-B3
D 121862147 cyclin-dependent kinase 1-like K02087 CDK1; cyclin-dependent kinase 1 [EC:2.7.11.22 2.7.11.23]
C Telomere proteins
D Shelterin complex
E 121863567 uncharacterized protein LOC121863567 isoform X1 K11113 TERF2IP; telomeric repeat-binding factor 2-interacting protein 1
D TERB1-TERB2-MAJIN complex
D CST complex (animals)
E 121867522 uncharacterized protein LOC121867522 isoform X1 K23311 CTC1; CST complex subunit CTC1
D CST complex (yeast)
D RIF proteins
D SIR proteins
C Telomerase complex (animals)
D 121877043 protein SMG5-like K11125 SMG5; protein SMG5
D Dyskerin complex
E 121875051 H/ACA ribonucleoprotein complex subunit 1-like K11128 GAR1; H/ACA ribonucleoprotein complex subunit 1
E 121855530 H/ACA ribonucleoprotein complex subunit 2-like protein K11129 NHP2; H/ACA ribonucleoprotein complex subunit 2
E 121869642 H/ACA ribonucleoprotein complex subunit 4-like isoform X1 K11131 DKC1; H/ACA ribonucleoprotein complex subunit 4 [EC:5.4.99.-]
C Telomerase complex (fungi)
D Sm core complex
E 121873732 LOW QUALITY PROTEIN: small nuclear ribonucleoprotein-associated protein B-like K11086 SNRPB; small nuclear ribonucleoprotein B and B'
E 121874469 small nuclear ribonucleoprotein-associated protein B-like K11086 SNRPB; small nuclear ribonucleoprotein B and B'
E 121878158 probable small nuclear ribonucleoprotein Sm D1 K11087 SNRPD1; small nuclear ribonucleoprotein D1
E 121875318 probable small nuclear ribonucleoprotein Sm D2 K11096 SNRPD2; small nuclear ribonucleoprotein D2
E 121878947 probable small nuclear ribonucleoprotein E K11097 SNRPE; small nuclear ribonucleoprotein E
E 121876782 small nuclear ribonucleoprotein F-like K11098 SNRPF; small nuclear ribonucleoprotein F
E 121866566 uncharacterized protein LOC121866566 K11098 SNRPF; small nuclear ribonucleoprotein F
E 121865026 probable small nuclear ribonucleoprotein G K11099 SNRPG; small nuclear ribonucleoprotein G
C ELG1-RFC complex
D 121861510 replication factor C subunit 2-like K10755 RFC2_4; replication factor C subunit 2/4
D 121871029 replication factor C subunit 4-like K10755 RFC2_4; replication factor C subunit 2/4
D 121873821 replication factor C subunit 5-like K10756 RFC3_5; replication factor C subunit 3/5
D 121874427 LOW QUALITY PROTEIN: replication factor C subunit 3-like K10756 RFC3_5; replication factor C subunit 3/5
C MRN complex
D 121874240 double-strand break repair protein MRE11-like K10865 MRE11; double-strand break repair protein MRE11
D 121868719 DNA repair protein RAD50-like isoform X1 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
D 121875310 nibrin-like K10867 NBN; nibrin
C Other termination factors
D 121854586 serine-protein kinase ATM-like K04728 ATM; serine-protein kinase ATM [EC:2.7.11.1]
D 121867148 Werner syndrome ATP-dependent helicase homolog K10900 WRN; werner syndrome ATP-dependent helicase [EC:5.6.2.4]
D 121854367 Bloom syndrome protein homolog isoform X1 K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
D 121856765 DNA-dependent protein kinase catalytic subunit-like K06642 PRKDC; DNA-dependent protein kinase catalytic subunit [EC:2.7.11.1]
D 121879875 poly [ADP-ribose] polymerase-like K24070 PARP1; poly [ADP-ribose] polymerase 1 [EC:2.4.2.30]
D 121874525 LOW QUALITY PROTEIN: protein mono-ADP-ribosyltransferase PARP3-like K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
D 121874642 poly [ADP-ribose] polymerase 2-like K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
D 121853976 poly [ADP-ribose] polymerase 2-like K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
D 121854784 protein mono-ADP-ribosyltransferase PARP3-like K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
D 121871401 uncharacterized protein LOC121871401 isoform X1 K10799 TNKS; tankyrase [EC:2.4.2.30]
D 121871917 poly [ADP-ribose] polymerase tankyrase-2-like isoform X1 K10799 TNKS; tankyrase [EC:2.4.2.30]
D 121853823 PIN2/TERF1-interacting telomerase inhibitor 1-like K11135 PINX1; Pin2-interacting protein X1
D 121870993 regulator of telomere elongation helicase 1 homolog K11136 RTEL1; regulator of telomere elongation helicase 1 [EC:5.6.2.3]
D 121879661 telomerase RNA component interacting RNase-like K01149 TRIR; telomerase RNA component interacting RNase [EC:3.1.13.-]
D 121864276 telomere-associated protein RIF1-like K11138 RIF1; telomere-associated protein RIF1
D 121874196 ATP-dependent DNA helicase PIF1-like isoform X1 K15255 PIF1; ATP-dependent DNA helicase PIF1 [EC:5.6.2.3]
D 121875094 uncharacterized protein LOC121875094 K15255 PIF1; ATP-dependent DNA helicase PIF1 [EC:5.6.2.3]
D 121875096 uncharacterized protein LOC121875096 K15255 PIF1; ATP-dependent DNA helicase PIF1 [EC:5.6.2.3]
D 121877696 uncharacterized protein LOC121877696 K15255 PIF1; ATP-dependent DNA helicase PIF1 [EC:5.6.2.3]
D 121879863 uncharacterized protein LOC121879863 K15255 PIF1; ATP-dependent DNA helicase PIF1 [EC:5.6.2.3]
D 121856832 uncharacterized protein LOC121856832 K15255 PIF1; ATP-dependent DNA helicase PIF1 [EC:5.6.2.3]
D 121870668 transcriptional activator protein Pur-beta-like isoform X1 K21772 PURA; transcriptional activator protein Pur-alpha
D 121864179 telomerase Cajal body protein 1-like K23314 WRAP53; telomerase Cajal body protein 1
D 121869983 replication stress response regulator SDE2-like K25059 SDE2; replication stress response regulator SDE2
D 121877927 replication termination factor 2-like K25186 RTF2; replication termination factor 2
B DNA Topoisomerases
C 121874678 DNA topoisomerase 2-like isoform X1 K03164 TOP2; DNA topoisomerase II [EC:5.6.2.2]
C 121877308 DNA topoisomerase 3-beta-1-like K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
C 121879728 DNA topoisomerase 3-alpha-like K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
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AProkaryotic type
B DNA Replication Initiation Factors
C Initiation factors (bacterial)
D 121868824 uncharacterized protein LOC121868824 isoform X1 K03111 ssb; single-strand DNA-binding protein
C Initiation factors (archaeal)
B DNA Replication Elongation Factors
C Elongation factors (bacterial)
D DNA polymerase III holoenzyme
D RNase H
E 121873231 ribonuclease H1-like isoform X1 K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
D Other elongation factors
C Elongation factors (archaeal)
D B-family DNA polymerases
D D-family DNA polymerases
D RNase H
E 121873231 ribonuclease H1-like isoform X1 K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
D RFC (replication factor C)
D Other elongation factors
E 121867963 flap endonuclease 1-like K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
E 121870130 DNA ligase 1-like isoform X1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
B DNA Replication Termination Factors
C Terminus site-binding protein
C DNA methylation enzymes
C Prevention of re-replication factors
B DNA Topoisomerases
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: November 2, 2022