+F Repair protein KO
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DNA Repair and Recombination Proteins - Natranaeroarchaeum sulfidigenes
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AEukaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D AArcS_2617 ada; Methylated DNA-protein cysteine methyltransferase K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
D AArcS_0106 phrB; Deoxyribodipyrimidine photolyase K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]
D AArcS_1395 phrB2; Deoxyribodipyrimidine photolyase K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]
C BER (base exicision repair)
D DNA glycosylases
E AArcS_1426 mutY; A/G-specific DNA glycosylase K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
E AArcS_0850 alkA; 3-methyladenine DNA glycosylase/8-oxoguanine DNAglycosylase K03660 OGG1; N-glycosylase/DNA lyase [EC:3.2.2.- 4.2.99.18]
E AArcS_1920 nth; EndoIII-related endonuclease K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
E AArcS_2343 nth2; EndoIII-related endonuclease K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
D Long Patch-BER factors
E DNA polymerase delta complex
E DNA polymerase epsilon complex
E AArcS_1738 dnaN; DNA polymerase sliding clamp subunit (PCNA-like protein) K04802 PCNA; proliferating cell nuclear antigen
E AArcS_3077 dnaN2; DNA polymerase sliding clamp subunit (PCNA-like protein) K04802 PCNA; proliferating cell nuclear antigen
E AArcS_1423 fen1; 5'-3' exonuclease K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
E AArcS_1457 cDC9; ATP-dependent DNA ligase K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
D Short Patch-BER factors
D Other BER factors
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E XPC-HR23B-CETN2 complex
E Cul4-DDB2 complex
E NER4 complex
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase II complex
E Cul4-CSA complex
E Other TCR factor
D TFIIH complex
E AArcS_0853 xpb; ssDNA-dependent ATPase, helicase superfamily II K10843 ERCC3; DNA excision repair protein ERCC-3 [EC:5.6.2.4]
E AArcS_0089 dinG; Rad3-related DNA helicase K10844 ERCC2; DNA excision repair protein ERCC-2 [EC:5.6.2.3]
E AArcS_0148 dinG2; Rad3-related DNA helicase K10844 ERCC2; DNA excision repair protein ERCC-2 [EC:5.6.2.3]
D RPA (replication factor A)
E AArcS_0324 rpa1; Single-stranded DNA-binding replication protein A (RPA), large (70 kD) subunit or related ssDNA-binding protein K07466 RFA1; replication factor A1
D Other NER factors
E AArcS_1457 cDC9; ATP-dependent DNA ligase K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
D MutL homologs
D DNA polymerase delta complex
D RPA (replication factor A)
E AArcS_0324 rpa1; Single-stranded DNA-binding replication protein A (RPA), large (70 kD) subunit or related ssDNA-binding protein K07466 RFA1; replication factor A1
D RFC (replication factor C)
D Other MMR factors
E AArcS_1738 dnaN; DNA polymerase sliding clamp subunit (PCNA-like protein) K04802 PCNA; proliferating cell nuclear antigen
E AArcS_3077 dnaN2; DNA polymerase sliding clamp subunit (PCNA-like protein) K04802 PCNA; proliferating cell nuclear antigen
E AArcS_1457 cDC9; ATP-dependent DNA ligase K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D MRN(MRX) complex
D BRCA1-core complex
D BRCA1-A complex
D BRCA1-B complex
D BRCA1-C complex
D BRCA complex
D RecA family proteins
D Rad52 family proteins
D Rad54 family proteins
D RecQ family DNA helicases
D Bloom's syndrome complex (BTR)
D RPA (replication factor A)
E AArcS_0324 rpa1; Single-stranded DNA-binding replication protein A (RPA), large (70 kD) subunit or related ssDNA-binding protein K07466 RFA1; replication factor A1
D Protein phosphatase 4
D AP-5 complex
D SMC5-SMC6 complex
D Other HR factors
C NHEJ (non-homologous end-joining)
D DNA-PK complex
D MRX complex
D DNA Ligase 4 complex
D X-family DNA polymerases
D Other NHEJ factors
C FA (Fanconi anemia) pathway
D FA core complex
D FA core complex binding factors
D Bloom's syndrome complex (BTR)
D FANCD2-I complex
D Downstream FA components
D Other FA pathway factors
C Other DSBR factors
D Protein phosphatase 6
D Ubiquitin ligases
D Others
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
C B-family DNA polymerases
C A-family DNA polymerase
C Rad6 epistasis group
C Other TLS factors
D AArcS_1738 dnaN; DNA polymerase sliding clamp subunit (PCNA-like protein) K04802 PCNA; proliferating cell nuclear antigen
D AArcS_3077 dnaN2; DNA polymerase sliding clamp subunit (PCNA-like protein) K04802 PCNA; proliferating cell nuclear antigen
B Check point factors
C Rad9-Hus1-Rad1 complex
C HRAD17(Rad24)-RFC complex
C Rad17-Mec3-Ddc1 complex
C FPC (fork protection complex)
C Triple T complex
C BAG6-UBL4A-GET4 complex
C Other check point factors
B Other factors with a suspected DNA repair function
C DNA polymerases
C Nucleases
C Helicases
C PSO4 complex
C Modulation of nucleotide pools
D AArcS_0636 NUDIX family hydrolase K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D AArcS_2126 dcd2; Deoxycytidine deaminase K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
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AProkaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D AArcS_2617 ada; Methylated DNA-protein cysteine methyltransferase K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
D AArcS_0106 phrB; Deoxyribodipyrimidine photolyase K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]
D AArcS_1395 phrB2; Deoxyribodipyrimidine photolyase K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]
D AArcS_1825 Uncharacterized protein K06876 phrB; (6-4)DNA photolyase [EC:4.1.99.13]
C BER (base exicision repair)
D DNA glycosylases
E AArcS_1510 Uracil-DNA glycosylase K21929 udg; uracil-DNA glycosylase [EC:3.2.2.27]
E AArcS_2482 Uracil-DNA glycosylase K21929 udg; uracil-DNA glycosylase [EC:3.2.2.27]
E AArcS_3127 Uracil-DNA glycosylase K21929 udg; uracil-DNA glycosylase [EC:3.2.2.27]
E AArcS_1942 alkA2; 3-methyladenine DNA glycosylase/8-oxoguanine DNAglycosylase K01247 alkA; DNA-3-methyladenine glycosylase II [EC:3.2.2.21]
E AArcS_1426 mutY; A/G-specific DNA glycosylase K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
E AArcS_1920 nth; EndoIII-related endonuclease K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
E AArcS_2343 nth2; EndoIII-related endonuclease K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
E AArcS_2257 nfo; Endonuclease IV K01151 nfo; deoxyribonuclease IV [EC:3.1.21.2]
E AArcS_2580 nfi; Deoxyinosine 3'endonuclease (endonuclease V) K05982 E3.1.21.7; deoxyribonuclease V [EC:3.1.21.7]
D RecJ
E AArcS_3135 recJ; Single-stranded DNA-specific exonuclease RecJ K07462 recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-]
D DNA ligase
E AArcS_0116 lig; NAD-dependent DNA ligase K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
D DNA polymerase I
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E AArcS_2909 uvrA; Excinuclease ABC subunit A, ATPase K03701 uvrA; excinuclease ABC subunit A
E AArcS_0076 uvrB; Excinuclease ABC subunit B, helicase K03702 uvrB; excinuclease ABC subunit B
E AArcS_3133 uvrC; Excinuclease ABC subunit C K03703 uvrC; excinuclease ABC subunit C
E AArcS_1787 recB; ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E AArcS_3005 uvrD; Superfamily I DNA and RNA helicase K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E AArcS_0116 lig; NAD-dependent DNA ligase K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase complex (RNAP)
E TRCF (transcription-repair coupling factor)
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
E AArcS_1755 mutS; Mismatch repair ATPase (MutS family) K03555 mutS; DNA mismatch repair protein MutS
E AArcS_2157 mutS2; Mismatch repair ATPase (MutS family) K03555 mutS; DNA mismatch repair protein MutS
E AArcS_2144 mutS2-1; DNA structure-specific ATPase involved in suppression of recombination, MutS family K07456 mutS2; DNA mismatch repair protein MutS2
E AArcS_3086 mutS2-2; DNA structure-specific ATPase involved in suppression of recombination, MutS family K07456 mutS2; DNA mismatch repair protein MutS2
D Molecular matchmaker
E AArcS_2153 mutL2; DNA mismatch repair enzyme (predicted ATPase) K03572 mutL; DNA mismatch repair protein MutL
D Strand discrimination factor
D DNA exonucleases
E AArcS_1624 xseA; Exonuclease VII, large subunit K03601 xseA; exodeoxyribonuclease VII large subunit [EC:3.1.11.6]
E AArcS_1625 hypothetical protein K03602 xseB; exodeoxyribonuclease VII small subunit [EC:3.1.11.6]
D DNA polymerase III holoenzyme
D DNA ligase
E AArcS_0116 lig; NAD-dependent DNA ligase K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
D Other MMR factors
E AArcS_1787 recB; ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E AArcS_3005 uvrD; Superfamily I DNA and RNA helicase K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D RecBC pathway proteins
E AArcS_2023 sbcC; ATPase involved in DNA repair, SbcC K03546 sbcC; DNA repair protein SbcC/Rad50
E AArcS_1659 sbcD; DNA repair exonuclease, SbcD K03547 sbcD; DNA repair protein SbcD/Mre11
E AArcS_2024 sbcD2; DNA repair exonuclease, SbcD K03547 sbcD; DNA repair protein SbcD/Mre11
D RecFOR pathway proteins
E AArcS_3135 recJ; Single-stranded DNA-specific exonuclease RecJ K07462 recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-]
D AddAB pathway proteins
D Other HR factor
E AArcS_2880 cas1; CRISPR-associated protein Cas1 K15342 cas1; CRISP-associated protein Cas1
D Archaeal homologous recombinant proteins
E AArcS_0290 recA; RecA/RadA recombinase K04483 radA; DNA repair protein RadA
E AArcS_2732 recA2; RecA/RadA recombinase K04484 radB; DNA repair protein RadB
E AArcS_3069 Holliday junction resolvase, archaeal type K03552 hjr; holliday junction resolvase [EC:3.1.21.10]
E AArcS_2023 sbcC; ATPase involved in DNA repair, SbcC K03546 sbcC; DNA repair protein SbcC/Rad50
E AArcS_1659 sbcD; DNA repair exonuclease, SbcD K03547 sbcD; DNA repair protein SbcD/Mre11
E AArcS_2024 sbcD2; DNA repair exonuclease, SbcD K03547 sbcD; DNA repair protein SbcD/Mre11
E AArcS_0032 bRR2; Replicative superfamily II helicase K03726 helS; ATP-dependent DNA helicase [EC:5.6.2.4]
E AArcS_0143 bRR21; Replicative superfamily II helicase K03726 helS; ATP-dependent DNA helicase [EC:5.6.2.4]
C NHEJ (non-homologous end-joining)
D Two-component NHEJ DNA repair complex
D SHIIR (short-homology-independent illegitimate recombination)
E Facilitator
F AArcS_1450 gyrA; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit K02469 gyrA; DNA gyrase subunit A [EC:5.6.2.2]
F AArcS_1451 gyrB; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit K02470 gyrB; DNA gyrase subunit B [EC:5.6.2.2]
F AArcS_0190 nucS; RecB family endonuclease acting on branched DNA substrates K03168 topA; DNA topoisomerase I [EC:5.6.2.1]
F AArcS_2055 Topoisomerase DNA binding C4 zinc finger fused to uncharacterized N-terminal domain often associated with RecB-like endonuclease K03168 topA; DNA topoisomerase I [EC:5.6.2.1]
E Supressor
D SHDIR (short-homology-dependent illegitimate recombination)
E RecET pathway
F AArcS_3135 recJ; Single-stranded DNA-specific exonuclease RecJ K07462 recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-]
F AArcS_0116 lig; NAD-dependent DNA ligase K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
E Facilitator
E Supressor
F AArcS_2909 uvrA; Excinuclease ABC subunit A, ATPase K03701 uvrA; excinuclease ABC subunit A
F AArcS_0076 uvrB; Excinuclease ABC subunit B, helicase K03702 uvrB; excinuclease ABC subunit B
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
D AArcS_0985 dpo4; Family Y DNA polymerase K04479 dbh; DNA polymerase IV (archaeal DinB-like DNA polymerase) [EC:2.7.7.7]
C Other SOS response factors
B Other factors with a suspected DNA repair function
C DNA polymerase
D AArcS_2577 pol4; DNA polymerase IV (family X) K02347 polX; DNA polymerase (family X)
C DNA helicases
D AArcS_0708 lhr; Lhr-like helicase K03724 lhr; ATP-dependent helicase Lhr and Lhr-like helicase [EC:5.6.2.6 5.6.2.4]
D AArcS_0872 lhr2; Lhr-like helicase K03724 lhr; ATP-dependent helicase Lhr and Lhr-like helicase [EC:5.6.2.6 5.6.2.4]
D AArcS_1604 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster K03724 lhr; ATP-dependent helicase Lhr and Lhr-like helicase [EC:5.6.2.6 5.6.2.4]
C Modulation of nucleotide pools
D AArcS_0636 NUDIX family hydrolase K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D AArcS_2126 dcd2; Deoxycytidine deaminase K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D AArcS_2932 nrdA; Ribonucleotide reductase, alpha subunit K00525 E1.17.4.1A; ribonucleoside-diphosphate reductase alpha chain [EC:1.17.4.1]
C Others
D AArcS_2570 Protein, predicted to be involved in DNA repair K22585 nreA; DNA repair protein NreA
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: March 29, 2024