+E	Replication protein	KO
#<h2><a href="/kegg/brite.html"><img src="/Fig/bget/kegg3.gif" align="middle" border=0></a>&nbsp; DNA Replication Proteins - Halococcoides cellulosivorans</h2>
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A<b>Eukaryotic type</b>
B  DNA Replication Initiation Factors
C    pre-RC (pre-replication complex)
C    CDK (cyclin dependent kinase)
C    DDK (Dbf-4 dependent kinase)
C    GINS complex
C    Other initiation factors
B  DNA Replication Elongation Factors
C    DNA polymerase alpha / primase complex
C    DNA polymerase epsilon complex
C    DNA polymerase delta complex
C    DNA polymerase gamma complex (mitochondrial)
C    RPA (replication protein A)
D      HARCEL1_09730 replication factor A	K07466 RFA1; replication factor A1 
C    RFC (replication factor C)
C    RNase H
D      HARCEL1_02885 ribonuclease H	K03469 rnhA; ribonuclease HI [EC:3.1.26.4] 
C    Other elongation factors
D      HARCEL1_00650 DNA polymerase sliding clamp	K04802 PCNA; proliferating cell nuclear antigen 
D      HARCEL1_07040 AAA family ATPase	K10742 DNA2; DNA replication ATP-dependent helicase/nuclease Dna2 [EC:5.6.2.3 3.1.-.-] 
D      HARCEL1_02435 fen; flap endonuclease-1	K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-] 
B  DNA Replication Termination Factors
C    DNA methylation enzymes
C    Prevention of re-replication factors
C    Telomere proteins
D      Shelterin complex
D      TERB1-TERB2-MAJIN complex
D      CST complex (animals)
D      CST complex (yeast)
D      RIF proteins
D      SIR proteins
C    Telomerase complex (animals)
D      Dyskerin complex
E        HARCEL1_08615 H/ACA RNA-protein complex component Nop10p	K11130 NOP10; H/ACA ribonucleoprotein complex subunit 3 
C    Telomerase complex (fungi)
D      Sm core complex
C    ELG1-RFC complex
C    MRN complex
C    Other termination factors
B  DNA Topoisomerases
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A<b>Prokaryotic type</b>
B  DNA Replication Initiation Factors
C    Initiation factors (bacterial)
D      HARCEL1_08335 DNA primase	K02316 dnaG; DNA primase [EC:2.7.7.101] 
C    Initiation factors (archaeal)
D      HARCEL1_00005 cell division control protein Cdc6	K10725 cdc6A; archaeal cell division control protein 6 
D      HARCEL1_03130 cdc6; cell division control protein 6	K10725 cdc6A; archaeal cell division control protein 6 
D      HARCEL1_11245 hypothetical protein	K10725 cdc6A; archaeal cell division control protein 6 
D      HARCEL1_12155 cell division control protein Cdc6	K10725 cdc6A; archaeal cell division control protein 6 
D      HARCEL1_09990 XRE family transcriptional regulator	K10726 mcm; replicative DNA helicase Mcm [EC:5.6.2.3] 
D      HARCEL1_12670 hypothetical protein	K10726 mcm; replicative DNA helicase Mcm [EC:5.6.2.3] 
D      HARCEL1_00505 priS; DNA primase catalytic subunit PriS	K02683 priS; DNA primase small subunit [EC:2.7.7.102] 
D      HARCEL1_08195 DNA primase regulatory subunit PriL	K18882 priL; DNA primase large subunit 
D      HARCEL1_00500 hypothetical protein	K09723 ginS; DNA replication factor GINS 
B  DNA Replication Elongation Factors
C    Elongation factors (bacterial)
D      DNA polymerase III holoenzyme
D      RNase H
E        HARCEL1_02885 ribonuclease H	K03469 rnhA; ribonuclease HI [EC:3.1.26.4] 
E        HARCEL1_02210 ribonuclease HII	K03470 rnhB; ribonuclease HII [EC:3.1.26.4] 
D      Other elongation factors
E        HARCEL1_04575 ligA; DNA ligase (NAD(+)) LigA	K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2] 
C    Elongation factors (archaeal)
D      B-family DNA polymerases
E        HARCEL1_06850 hypothetical protein	K02319 pol; DNA polymerase, archaea type [EC:2.7.7.7] 
E        HARCEL1_10990 DNA polymerase I	K02319 pol; DNA polymerase, archaea type [EC:2.7.7.7] 
E        HARCEL1_12735 DNA polymerase I	K02319 pol; DNA polymerase, archaea type [EC:2.7.7.7] 
D      D-family DNA polymerases
E        HARCEL1_02150 polC; DNA polymerase II large subunit	K02322 polC; DNA polymerase II large subunit [EC:2.7.7.7] 
E        HARCEL1_13205 DNA polymerase II	K02323 polB; DNA polymerase II small subunit [EC:2.7.7.7] 
D      RNase H
E        HARCEL1_02885 ribonuclease H	K03469 rnhA; ribonuclease HI [EC:3.1.26.4] 
E        HARCEL1_02210 ribonuclease HII	K03470 rnhB; ribonuclease HII [EC:3.1.26.4] 
D      RFC (replication factor C)
E        HARCEL1_07520 AAA family ATPase	K04800 rfcL; replication factor C large subunit 
E        HARCEL1_01140 replication factor C small subunit 2	K04801 rfcS; replication factor C small subunit 
E        HARCEL1_05470 replication factor C small subunit	K04801 rfcS; replication factor C small subunit 
D      Other elongation factors
E        HARCEL1_07040 AAA family ATPase	K10742 DNA2; DNA replication ATP-dependent helicase/nuclease Dna2 [EC:5.6.2.3 3.1.-.-] 
E        HARCEL1_02435 fen; flap endonuclease-1	K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-] 
B  DNA Replication Termination Factors
C    Terminus site-binding protein
C    DNA methylation enzymes
C    Prevention of re-replication factors
B  DNA Topoisomerases
C    HARCEL1_01940 DNA gyrase subunit A	K02469 gyrA; DNA gyrase subunit A [EC:5.6.2.2] 
C    HARCEL1_01935 gyrB; DNA topoisomerase (ATP-hydrolyzing) subunit B	K02470 gyrB; DNA gyrase subunit B [EC:5.6.2.2] 
C    HARCEL1_02720 DNA topoisomerase VI	K03166 top6A; DNA topoisomerase VI subunit A [EC:5.6.2.2] 
C    HARCEL1_02725 DNA topoisomerase VI subunit B	K03167 top6B; DNA topoisomerase VI subunit B [EC:5.6.2.2] 
C    HARCEL1_09235 DNA topoisomerase I	K03168 topA; DNA topoisomerase I [EC:5.6.2.1] 
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#Last updated: August 27, 2025