+F Repair protein KO
#
DNA Repair and Recombination Proteins - Helicoverpa armigera (cotton bollworm)
%
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AEukaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D 110376272 activating signal cointegrator 1 complex subunit 3 K18663 ASCC3; activating signal cointegrator complex subunit 3 [EC:5.6.2.4]
D 110372894 deoxyribodipyrimidine photo-lyase K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]
C BER (base exicision repair)
D DNA glycosylases
E 110382226 LOW QUALITY PROTEIN: uncharacterized protein LOC110382226 K20813 TDG; thymine-DNA glycosylase [EC:3.2.2.29]
E 110378610 single-strand selective monofunctional uracil DNA glycosylase isoform X1 K10800 SMUG1; single-strand selective monofunctional uracil DNA glycosylase [EC:3.2.2.-]
E 110370771 methyl-CpG-binding domain protein 4 K10801 MBD4; methyl-CpG-binding domain protein 4 [EC:3.2.2.-]
E 110375625 N-glycosylase/DNA lyase isoform X1 K03660 OGG1; N-glycosylase/DNA lyase [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
E 110374398 DNA-(apurinic or apyrimidinic site) endonuclease K10771 APEX1; AP endonuclease 1 [EC:3.1.11.2]
D Long Patch-BER factors
E DNA polymerase delta complex
F 110375678 Pold1; DNA polymerase delta catalytic subunit K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
F 110370208 DNA polymerase delta subunit 2 K02328 POLD2; DNA polymerase delta subunit 2
F 110379575 DNA polymerase delta subunit 3 K03504 POLD3; DNA polymerase delta subunit 3
E DNA polymerase epsilon complex
F 110376426 Pole1; DNA polymerase epsilon catalytic subunit 1 K02324 POLE; DNA polymerase epsilon subunit 1 [EC:2.7.7.7]
F 110374007 DNA polymerase epsilon subunit 2 K02325 POLE2; DNA polymerase epsilon subunit 2 [EC:2.7.7.7]
F 110381475 DNA polymerase epsilon subunit 3 K02326 POLE3; DNA polymerase epsilon subunit 3 [EC:2.7.7.7]
F 110375003 DNA polymerase epsilon subunit 4 K03506 POLE4; DNA polymerase epsilon subunit 4 [EC:2.7.7.7]
E 110370506 proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
E 110383072 flap endonuclease 1 K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
E 110376636 Dnalig1; DNA ligase 1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
D Short Patch-BER factors
E 110381584 DNA repair protein XRCC1 K10803 XRCC1; DNA-repair protein XRCC1
E 110381686 Dnalig3; DNA ligase 3 K10776 LIG3; DNA ligase 3 [EC:6.5.1.1]
D Other BER factors
E 110380114 gkt; probable tyrosyl-DNA phosphodiesterase isoform X1 K10862 TDP1; tyrosyl-DNA phosphodiesterase 1 [EC:3.1.4.-]
E 110379623 aprataxin K10863 APTX; aprataxin [EC:3.6.1.70 3.6.1.71 3.6.1.72]
E 110375975 aprataxin and PNK-like factor isoform X1 K13295 APLF; aprataxin and PNK-like factor [EC:3.1.-.-]
E 110374775 uncharacterized protein F21D5.5 K08073 PNKP; bifunctional polynucleotide phosphatase/kinase [EC:3.1.3.32 2.7.1.78]
E 110371859 high mobility group protein DSP1 isoform X1 K10802 HMGB1; high mobility group protein B1
E 110384099 poly [ADP-ribose] polymerase K24070 PARP1; poly [ADP-ribose] polymerase 1 [EC:2.4.2.30]
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E XPC-HR23B-CETN2 complex
F 110372319 DNA repair protein complementing XP-C cells homolog K10838 XPC; xeroderma pigmentosum group C-complementing protein
F 110369957 UV excision repair protein RAD23 homolog A K10839 RAD23; UV excision repair protein RAD23
F 110380819 uncharacterized protein LOC110380819 isoform X1 K10840 CETN2; centrin-2
E Cul4-DDB2 complex
F 110372277 RING-box protein 1A K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
F 110372899 cullin-4A K10609 CUL4; cullin 4
F 110372494 pic; DNA damage-binding protein 1 K10610 DDB1; DNA damage-binding protein 1
E NER4 complex
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase II complex
F 110375127 DNA-directed RNA polymerase II subunit RPB1 K03006 RPB1; DNA-directed RNA polymerase II subunit RPB1 [EC:2.7.7.6]
F 110373110 Polr2b; DNA-directed RNA polymerase II subunit RPB2 K03010 RPB2; DNA-directed RNA polymerase II subunit RPB2 [EC:2.7.7.6]
F 110373408 DNA-directed RNA polymerase II subunit RPB3 K03011 RPB3; DNA-directed RNA polymerase II subunit RPB3
F 110375872 DNA-directed RNA polymerase II subunit Rpb4 K03012 RPB4; DNA-directed RNA polymerase II subunit RPB4
F 110370556 DNA-directed RNA polymerases I, II, and III subunit RPABC1 K03013 RPABC1; DNA-directed RNA polymerases I, II, and III subunit RPABC1
F 110376854 DNA-directed RNA polymerases I, II, and III subunit RPABC2 K03014 RPABC2; DNA-directed RNA polymerases I, II, and III subunit RPABC2
F 110376434 DNA-directed RNA polymerase II subunit RPB7 K03015 RPB7; DNA-directed RNA polymerase II subunit RPB7
F 110382505 DNA-directed RNA polymerases I, II, and III subunit RPABC3 K03016 RPABC3; DNA-directed RNA polymerases I, II, and III subunit RPABC3
F 110379837 DNA-directed RNA polymerase II subunit RPB9 K03017 RPB9; DNA-directed RNA polymerase II subunit RPB9
F 110382944 DNA-directed RNA polymerases I, II, and III subunit RPABC5 K03007 RPABC5; DNA-directed RNA polymerases I, II, and III subunit RPABC5
F 110372607 DNA-directed RNA polymerase II subunit RPB11 K03008 RPB11; DNA-directed RNA polymerase II subunit RPB11
F 110378920 DNA-directed RNA polymerases I, II, and III subunit RPABC4 K03009 RPABC4; DNA-directed RNA polymerases I, II, and III subunit RPABC4
E Cul4-CSA complex
F 110372277 RING-box protein 1A K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
F 110372899 cullin-4A K10609 CUL4; cullin 4
F 110372494 pic; DNA damage-binding protein 1 K10610 DDB1; DNA damage-binding protein 1
E Other TCR factor
F 110377966 DNA excision repair protein ERCC-6 K10841 ERCC6; DNA excision repair protein ERCC-6
F 135118474 DNA excision repair protein ERCC-6-like K10841 ERCC6; DNA excision repair protein ERCC-6
F 110374810 transcription elongation factor 1 homolog K25829 ELOF1; transcription elongation factor 1
D TFIIH complex
E 110379631 general transcription and DNA repair factor IIH helicase subunit XPB K10843 ERCC3; DNA excision repair protein ERCC-3 [EC:5.6.2.4]
E 110378851 xpd; general transcription and DNA repair factor IIH helicase subunit XPD K10844 ERCC2; DNA excision repair protein ERCC-2 [EC:5.6.2.3]
E 110373735 general transcription factor IIH subunit 1 K03141 TFIIH1; transcription initiation factor TFIIH subunit 1
E 110374693 general transcription factor IIH subunit 2 K03142 TFIIH2; transcription initiation factor TFIIH subunit 2
E 110373611 general transcription factor IIH subunit 3 K03143 TFIIH3; transcription initiation factor TFIIH subunit 3
E 110377909 mrn; general transcription factor IIH subunit 4 isoform X1 K03144 TFIIH4; transcription initiation factor TFIIH subunit 4
E 110373225 general transcription factor IIH subunit 5 K10845 TTDA; TFIIH basal transcription factor complex TTD-A subunit
E 110384275 cdk7; cyclin-dependent kinase 7 K02202 CDK7; cyclin-dependent kinase 7 [EC:2.7.11.22 2.7.11.23]
E 110376775 cyclin-H K06634 CCNH; cyclin H
E 110381013 CDK-activating kinase assembly factor MAT1 K10842 MNAT1; CDK-activating kinase assembly factor MAT1
D RPA (replication factor A)
E 110374725 replication protein A 70 kDa DNA-binding subunit K07466 RFA1; replication factor A1
E 110374791 rpa2; replication protein A 32 kDa subunit K10739 RFA2; replication factor A2
D Other NER factors
E 110383957 DNA excision repair protein ERCC-1 K10849 ERCC1; DNA excision repair protein ERCC-1
E 110384442 LOW QUALITY PROTEIN: DNA repair endonuclease XPF K10848 ERCC4; DNA excision repair protein ERCC-4 [EC:3.1.-.-]
E 110373067 DNA excision repair protein ERCC-5 homolog isoform X1 K10846 ERCC5; DNA excision repair protein ERCC-5
E 110376636 Dnalig1; DNA ligase 1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
E 110378420 MMS19 nucleotide excision repair protein homolog K15075 MET18; DNA repair/transcription protein MET18/MMS19
E 110371915 cul3; cullin-3 isoform X1 K03869 CUL3; cullin 3
E 110370324 cul5; cullin-5 K10612 CUL5; cullin 5
E 110379554 eloC; elongin-C K03872 ELOC; elongin-C
E 110380018 elongin-B K03873 ELOB; elongin-B
E 110380458 transcription elongation factor B polypeptide 3 K15076 ELOA; elongin-A
E 110383306 protein lingerer K26545 UBAP2; ubiquitin-associated protein 2
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
E 110380087 DNA mismatch repair protein Msh2 K08735 MSH2; DNA mismatch repair protein MSH2
D MutL homologs
E 110380300 DNA mismatch repair protein Mlh1 K08734 MLH1; DNA mismatch repair protein MLH1
E 110370052 mismatch repair endonuclease PMS2 K10858 PMS2; DNA mismatch repair protein PMS2
E 110375659 uncharacterized protein LOC110375659 K08739 MLH3; DNA mismatch repair protein MLH3
D DNA polymerase delta complex
E 110375678 Pold1; DNA polymerase delta catalytic subunit K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
E 110370208 DNA polymerase delta subunit 2 K02328 POLD2; DNA polymerase delta subunit 2
E 110379575 DNA polymerase delta subunit 3 K03504 POLD3; DNA polymerase delta subunit 3
D RPA (replication factor A)
E 110374725 replication protein A 70 kDa DNA-binding subunit K07466 RFA1; replication factor A1
E 110374791 rpa2; replication protein A 32 kDa subunit K10739 RFA2; replication factor A2
D RFC (replication factor C)
E 110383374 replication factor C subunit 1 K10754 RFC1; replication factor C subunit 1
E 110371094 replication factor C subunit 4 K10755 RFC2_4; replication factor C subunit 2/4
E 110380397 rfc4; replication factor C subunit 2 K10755 RFC2_4; replication factor C subunit 2/4
E 110372793 replication factor C subunit 5 K10756 RFC3_5; replication factor C subunit 3/5
E 110377481 rfc38; replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
D Other MMR factors
E 110370506 proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
E 110372013 exonuclease 1 K10746 EXO1; exonuclease 1 [EC:3.1.-.-]
E 110371859 high mobility group protein DSP1 isoform X1 K10802 HMGB1; high mobility group protein B1
E 110376636 Dnalig1; DNA ligase 1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D MRN(MRX) complex
E 110379039 LOW QUALITY PROTEIN: double-strand break repair protein MRE11 K10865 MRE11; double-strand break repair protein MRE11
E 110374746 DNA repair protein RAD50 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
E 110375935 nbs; nibrin isoform X1 K10867 NBN; nibrin
D BRCA1-core complex
E 110376133 breast cancer type 1 susceptibility protein homolog isoform X1 K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 110381420 BRCA1-associated RING domain protein 1 K10683 BARD1; BRCA1-associated RING domain protein 1
D BRCA1-A complex
E 110376133 breast cancer type 1 susceptibility protein homolog isoform X1 K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 110381274 BRISC complex subunit FAM175B isoform X1 K20774 FAM175A; BRCA1-A complex subunit Abraxas
E 110383898 BRISC and BRCA1-A complex member 1 K20776 BABAM; BRISC and BRCA1-A complex member 1
E 110384078 BRISC and BRCA1-A complex member 2 K12173 BRE; BRCA1-A complex subunit BRE
E 110369935 lys-63-specific deubiquitinase BRCC36 K11864 BRCC3; BRCA1/BRCA2-containing complex subunit 3 [EC:3.4.19.-]
D BRCA1-B complex
E 110376133 breast cancer type 1 susceptibility protein homolog isoform X1 K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 110375603 Fanconi anemia group J protein homolog isoform X1 K15362 BRIP1; fanconi anemia group J protein [EC:5.6.2.3]
E 110383085 DNA topoisomerase 2-binding protein 1 K10728 TOPBP1; topoisomerase (DNA) II binding protein 1
D BRCA1-C complex
E 110376133 breast cancer type 1 susceptibility protein homolog isoform X1 K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 110379039 LOW QUALITY PROTEIN: double-strand break repair protein MRE11 K10865 MRE11; double-strand break repair protein MRE11
E 110374746 DNA repair protein RAD50 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
E 110375935 nbs; nibrin isoform X1 K10867 NBN; nibrin
D BRCA complex
E 110376133 breast cancer type 1 susceptibility protein homolog isoform X1 K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 110382284 breast cancer type 2 susceptibility protein K08775 BRCA2; breast cancer 2 susceptibility protein
E 110377470 Spn-a; DNA repair protein RAD51 homolog 1 K04482 RAD51; DNA repair protein RAD51
D RecA family proteins
E 110377470 Spn-a; DNA repair protein RAD51 homolog 1 K04482 RAD51; DNA repair protein RAD51
E 110377231 DNA repair protein RAD51 homolog 3 K10870 RAD51L2; RAD51-like protein 2
E 110373415 DNA repair protein XRCC3 K10880 XRCC3; DNA-repair protein XRCC3
D Rad52 family proteins
E 110381302 basic proline-rich protein isoform X1 K10873 RAD52; DNA repair and recombination protein RAD52
D Rad54 family proteins
E 110370849 DNA repair and recombination protein RAD54-like K10875 RAD54L; DNA repair and recombination protein RAD54 and RAD54-like protein [EC:5.6.2.-]
E 110384064 uncharacterized protein LOC110384064 K10876 RAD54L2; RAD54-like protein 2 [EC:5.6.2.-]
D RecQ family DNA helicases
E 110379000 ATP-dependent DNA helicase Q1 K10899 RECQL; ATP-dependent DNA helicase Q1 [EC:5.6.2.4]
E 110376918 RecQ-like DNA helicase Blm K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 110370115 LOW QUALITY PROTEIN: ATP-dependent DNA helicase Q4 K10730 RECQL4; ATP-dependent DNA helicase Q4 [EC:5.6.2.4]
E 110371616 ATP-dependent DNA helicase Q5 K10902 RECQL5; ATP-dependent DNA helicase Q5 [EC:5.6.2.4]
D Bloom's syndrome complex (BTR)
E 110376918 RecQ-like DNA helicase Blm K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 110376704 LOW QUALITY PROTEIN: DNA topoisomerase 3-beta-1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 110375433 DNA topoisomerase 3-alpha K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 110382076 RecQ-mediated genome instability protein 1-like K10990 RMI1; RecQ-mediated genome instability protein 1
D RPA (replication factor A)
E 110374725 replication protein A 70 kDa DNA-binding subunit K07466 RFA1; replication factor A1
E 110374791 rpa2; replication protein A 32 kDa subunit K10739 RFA2; replication factor A2
D Protein phosphatase 4
E 110370777 serine/threonine-protein phosphatase 4 catalytic subunit K15423 PPP4C; serine/threonine-protein phosphatase 4 catalytic subunit [EC:3.1.3.16]
E 110384520 serine/threonine-protein phosphatase 4 regulatory subunit 2 K15425 PPP4R2; serine/threonine-protein phosphatase 4 regulatory subunit 2
E 110379582 serine/threonine-protein phosphatase 4 regulatory subunit 3 isoform X1 K17491 SMEK; protein phosphatase 4 regulatory subunit 3
D AP-5 complex
D SMC5-SMC6 complex
E 110371161 structural maintenance of chromosomes protein 5 K22803 SMC5; structural maintenance of chromosomes protein 5
E 110375651 non-structural maintenance of chromosomes element 1 homolog K22817 NSMCE1; non-structural maintenance of chromosomes element 1 [EC:2.3.2.27]
E 110370466 E3 SUMO-protein ligase NSE2 K22756 NSMCE2; E3 SUMO-protein ligase NSE2 [EC:2.3.2.-]
E 110373181 non-structural maintenance of chromosomes element 3 homolog K22823 NSMCE3; non-structural maintenance of chromosomes element 3
E 110381771 EP300-interacting inhibitor of differentiation 3 K22825 NSMCE4; non-structural maintenance of chromosomes element 4
D Other HR factors
E 110373654 crossover junction endonuclease EME1 K10882 EME1; crossover junction endonuclease EME1 [EC:3.1.22.-]
E 110376593 exonuclease 3'-5' domain-containing protein 2 K20777 EXD2; exonuclease 3'-5' domain-containing protein 2 [EC:3.1.11.1]
E 110378453 crossover junction endonuclease MUS81 K08991 MUS81; crossover junction endonuclease MUS81 [EC:3.1.22.-]
E 110381984 structure-specific endonuclease subunit SLX1 homolog K15078 SLX1; structure-specific endonuclease subunit SLX1 [EC:3.6.1.-]
E 110384038 gen; flap endonuclease GEN isoform X1 K15338 GEN1; holliday junction resolvase GEN1/YEN1 [EC:3.1.-.-]
E 110369938 spatacsin isoform X1 K19026 SPG11; spatacsin
E 110378585 LOW QUALITY PROTEIN: zinc finger FYVE domain-containing protein 26 homolog K19027 ZFYVE26; zinc finger FYVE domain-containing protein 26
E 110384279 mortality factor 4-like protein 1 K11339 MORF4L1; mortality factor 4-like protein 1
E 110372703 fidgetin-like protein 1 K22766 FIGNL1; fidgetin-like protein 1 [EC:5.6.2.-]
E 110372088 uncharacterized protein LOC110372088 isoform X1 K23112 BRAT1; BRCA1-associated ATM activator 1
E 110372089 uncharacterized protein LOC110372089 K23112 BRAT1; BRCA1-associated ATM activator 1
E 110380414 cilia- and flagella-associated protein 410 isoform X1 K23456 CFAP410; cilla- and flagella-associated protein
E 110373124 BRCA2-interacting transcriptional repressor EMSY K25790 EMSY; BRCA2-interacting transcriptional repressor EMSY
E 110371994 tonsoku-like protein K09257 NFKBIL2; NF-kappa-B inhibitor-like protein 2
E 110376039 biorientation of chromosomes in cell division protein 1-like 1 isoform X1 K27262 BOD1L1; biorientation of chromosomes in cell division protein 1-like 1
C NHEJ (non-homologous end-joining)
D DNA-PK complex
E 110371257 ATP-dependent DNA helicase 2 subunit 1 K10884 XRCC6; ATP-dependent DNA helicase 2 subunit 1
E 110380517 X-ray repair cross-complementing protein 5 K10885 XRCC5; ATP-dependent DNA helicase 2 subunit 2
D MRX complex
E 110379039 LOW QUALITY PROTEIN: double-strand break repair protein MRE11 K10865 MRE11; double-strand break repair protein MRE11
E 110374746 DNA repair protein RAD50 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
D DNA Ligase 4 complex
E 110378545 DNA ligase 4 K10777 LIG4; DNA ligase 4 [EC:6.5.1.1]
E 110383963 non-homologous end-joining factor 1 K10980 NHEJ1; non-homologous end-joining factor 1
D X-family DNA polymerases
D Other NHEJ factors
E 110379623 aprataxin K10863 APTX; aprataxin [EC:3.6.1.70 3.6.1.71 3.6.1.72]
E 110375975 aprataxin and PNK-like factor isoform X1 K13295 APLF; aprataxin and PNK-like factor [EC:3.1.-.-]
E 126054406 protein artemis-like K10887 DCLRE1C; DNA cross-link repair 1C protein [EC:3.1.-.-]
C FA (Fanconi anemia) pathway
D FA core complex
E 110370100 uncharacterized protein LOC110370100 K10606 FANCL; E3 ubiquitin-protein ligase FANCL [EC:2.3.2.27]
E 135117603 E3 ubiquitin-protein ligase Fancl K10606 FANCL; E3 ubiquitin-protein ligase FANCL [EC:2.3.2.27]
E 110383937 Fanconi anemia group M protein K10896 FANCM; fanconi anemia group M protein
D FA core complex binding factors
E 110372237 centromere protein S K11511 APITD1; centromere protein S
E 110371248 centromere protein X K15360 STRA13; centromere protein X
E 110376667 ubiquitin-conjugating enzyme E2 T K13960 UBE2T; ubiquitin-conjugating enzyme E2 T [EC:2.3.2.23]
D Bloom's syndrome complex (BTR)
E 110376918 RecQ-like DNA helicase Blm K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 110376704 LOW QUALITY PROTEIN: DNA topoisomerase 3-beta-1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 110375433 DNA topoisomerase 3-alpha K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 110382076 RecQ-mediated genome instability protein 1-like K10990 RMI1; RecQ-mediated genome instability protein 1
D FANCD2-I complex
E 110384685 Fanconi anemia group D2 protein K10891 FANCD2; fanconi anemia group D2 protein
D Downstream FA components
E 110376133 breast cancer type 1 susceptibility protein homolog isoform X1 K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 110382284 breast cancer type 2 susceptibility protein K08775 BRCA2; breast cancer 2 susceptibility protein
E 110375603 Fanconi anemia group J protein homolog isoform X1 K15362 BRIP1; fanconi anemia group J protein [EC:5.6.2.3]
D Other FA pathway factors
E 110370590 fanconi-associated nuclease 1 K15363 FAN1; fanconi-associated nuclease 1 [EC:3.1.21.- 3.1.4.1]
E 110377470 Spn-a; DNA repair protein RAD51 homolog 1 K04482 RAD51; DNA repair protein RAD51
E 110377231 DNA repair protein RAD51 homolog 3 K10870 RAD51L2; RAD51-like protein 2
E 110383949 uncharacterized protein LOC110383949 K11832 USP1; ubiquitin carboxyl-terminal hydrolase 1 [EC:3.4.19.12]
E 110381704 WD repeat-containing protein 48 homolog K15361 WDR48; WD repeat-containing protein 48
C Other DSBR factors
D Protein phosphatase 6
E 110374431 serine/threonine-protein phosphatase 6 catalytic subunit K15498 PPP6C; serine/threonine-protein phosphatase 6 catalytic subunit [EC:3.1.3.16]
E 110372792 LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 6 regulatory subunit 3 K15501 PPP6R3; serine/threonine-protein phosphatase 6 regulatory subunit 3
D Ubiquitin ligases
E 110371607 E3 ubiquitin-protein ligase RNF8 isoform X1 K10667 RNF8; E3 ubiquitin-protein ligase RNF8 [EC:2.3.2.27]
E 110383776 uncharacterized protein LOC110383776 K20779 RNF168; E3 ubiquitin-protein ligase RNF168 [EC:2.3.2.31]
E 110374456 probable E3 ubiquitin-protein ligase HERC2 K10595 HERC2; E3 ubiquitin-protein ligase HERC2 [EC:2.3.2.26]
D Others
E 110384567 telomerase Cajal body protein 1 homolog K23314 WRAP53; telomerase Cajal body protein 1
E 110372576 zinc finger CW-type PWWP domain protein 1 K24688 ZCWPW1; zinc finger CW-type PWWP domain protein 1
E 110377427 gastrulation defective protein 1 homolog K24752 WDR70; WD repeat-containing protein 70
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
D 110372687 DNA polymerase eta K03509 POLH; DNA polymerase eta [EC:2.7.7.7]
D 110382171 DNA polymerase iota K03510 POLI; DNA polymerase iota [EC:2.7.7.7]
D 110384601 DNA repair protein REV1 K03515 REV1; DNA repair protein REV1 [EC:2.7.7.-]
C B-family DNA polymerases
D 110383921 DNA polymerase zeta catalytic subunit isoform X2 K02350 REV3L; DNA polymerase zeta [EC:2.7.7.7]
C A-family DNA polymerase
C Rad6 epistasis group
D 110377260 ubiquitin-conjugating enzyme E2-17 kDa K10573 UBE2A; ubiquitin-conjugating enzyme E2 A [EC:2.3.2.23]
D 110379627 ubiquitin-conjugating enzyme E2 variant 2 K10704 UBE2V; ubiquitin-conjugating enzyme E2 variant
D 110377527 ubiquitin-conjugating enzyme E2 N K10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23]
C Other TLS factors
D 110370506 proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
D 110381284 Mh; DNA-dependent metalloprotease dvc-1 K24051 SPRTN; SprT-like domain-contaning protein Spartan
D 110372404 uncharacterized protein LOC110372404 K26957 GCNA; germ cell nuclear acidic protein
B Check point factors
C Rad9-Hus1-Rad1 complex
D 110370917 cell cycle checkpoint control protein RAD9A K10994 RAD9A; cell cycle checkpoint control protein RAD9A [EC:3.1.11.2]
D 110378791 checkpoint protein HUS1 isoform X1 K10903 HUS1; HUS1 checkpoint protein
D 110370768 cell cycle checkpoint protein RAD1 K02830 HRAD1; cell cycle checkpoint protein [EC:3.1.11.2]
C HRAD17(Rad24)-RFC complex
D 110374781 cell cycle checkpoint protein RAD17 isoform X1 K06662 HRAD17; cell cycle checkpoint protein
D 110371094 replication factor C subunit 4 K10755 RFC2_4; replication factor C subunit 2/4
D 110380397 rfc4; replication factor C subunit 2 K10755 RFC2_4; replication factor C subunit 2/4
D 110372793 replication factor C subunit 5 K10756 RFC3_5; replication factor C subunit 3/5
D 110377481 rfc38; replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
C Rad17-Mec3-Ddc1 complex
D 110370768 cell cycle checkpoint protein RAD1 K02830 HRAD1; cell cycle checkpoint protein [EC:3.1.11.2]
C FPC (fork protection complex)
D 110374643 protein timeless homolog isoform X1 K10997 TIMELESS; replication fork protection complex subunit TIMELESS/Tof1/Swi1
D 135118628 uncharacterized protein LOC135118628 K10998 TIPIN; replication fork protection complex subunit TIPIN/Csm3/Swi3
D 110382045 uncharacterized protein LOC110382045 K10998 TIPIN; replication fork protection complex subunit TIPIN/Csm3/Swi3
C Triple T complex
D 110375338 LOW QUALITY PROTEIN: TELO2-interacting protein 1 homolog K20403 TTI1; TELO2-interacting protein 1
D 110383959 uncharacterized protein LOC110383959 K23115 TTI2; TELO2-interacting protein 2
C BAG6-UBL4A-GET4 complex
D 110379990 large proline-rich protein BAG6 K23390 BAG6; large proline-rich protein BAG6
D 110374544 ubiquitin-like protein 4A-B K23388 UBL4; ubiquitin-like protein 4
D 110375765 Golgi to ER traffic protein 4 homolog K23387 GET4; golgi to ER traffic protein 4
C Other check point factors
D 110375320 serine/threonine-protein kinase ATR K06640 ATR; serine/threonine-protein kinase ATR [EC:2.7.11.1]
D 110371961 serine-protein kinase ATM K04728 ATM; serine-protein kinase ATM [EC:2.7.11.1]
D 110371726 cellular tumor antigen P53 K04451 TP53; tumor protein p53
D 110374774 ovarian-specific serine/threonine-protein kinase Lok K06641 CHEK2; serine/threonine-protein kinase CHEK2 [EC:2.7.11.1]
D 110380949 M-phase inducer phosphatase isoform X1 K05866 CDC25B; M-phase inducer phosphatase 2 [EC:3.1.3.48]
D 110380469 14-3-3 protein zeta isoform X1 K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
D 110371684 14-3-3 protein epsilon K06630 YWHAE; 14-3-3 protein epsilon
D 110375535 sicK; protein sickie isoform X12 K19483 NAV2; neuron navigator 2 [EC:5.6.2.4]
D 110382763 wee1-like protein kinase K06632 WEE1; wee1-like protein kinase [EC:2.7.11.1]
D 110374515 period circadian protein isoform X1 K02633 PER2; period circadian protein 2
D 110372136 uncharacterized protein LOC110372136 isoform X1 K20780 MDC1; mediator of DNA damage checkpoint protein 1
D 110379742 plastin-3 K17336 PLS3; plastin-3
D 110378715 Hd; protein downstream neighbor of son homolog K22422 DONSON; protein downstream neighbor of Son
D 110375638 vps4; vacuolar protein sorting-associated protein 4 K12196 VPS4; vacuolar protein-sorting-associated protein 4
D 110373416 abscission/NoCut checkpoint regulator isoform X3 K24778 ZFYVE19; abscission/NoCut checkpoint regulator
D 110376669 splicing regulator SDE2 K25059 SDE2; replication stress response regulator SDE2
B Other factors with a suspected DNA repair function
C DNA polymerases
D 110383930 DNA polymerase theta K02349 POLQ; DNA polymerase theta [EC:2.7.7.7]
D 110370799 myb-binding protein 1A-like protein K02331 POL5; DNA polymerase phi [EC:2.7.7.7]
C Nucleases
D 110371475 uncharacterized protein LOC110371475 K10790 TREX1; three prime repair exonuclease 1 [EC:3.1.11.2]
D 110373659 DNA cross-link repair 1A protein isoform X3 K15340 DCLRE1A; DNA cross-link repair 1A protein
D 110371242 ankyrin repeat and LEM domain-containing protein 1 K21411 ANKLE1; ankyrin repeat and LEM domain-containing protein 1
C Helicases
D 110374211 mus301; helicase POLQ-like K19178 HELQ; POLQ-like helicase [EC:5.6.2.4]
C PSO4 complex
D 135117337 prp19; pre-mRNA-processing factor 19 K10599 PRPF19; pre-mRNA-processing factor 19 [EC:2.3.2.27]
D 110383938 cdc5; cell division cycle 5-like protein K12860 CDC5L; pre-mRNA-splicing factor CDC5/CEF1
D 110381904 pre-mRNA-splicing factor SPF27 K12861 BCAS2; pre-mRNA-splicing factor SPF27
D 110376096 pleiotropic regulator 1 isoform X2 K12862 PLRG1; pleiotropic regulator 1
C Modulation of nucleotide pools
D 110382494 oxidized purine nucleoside triphosphate hydrolase K17816 NUDT1; 8-oxo-dGTP diphosphatase / 2-hydroxy-dATP diphosphatase [EC:3.6.1.55 3.6.1.56]
D 110370267 8-oxo-dGDP phosphatase NUDT18 K17817 NUDT18; 8-oxo-dGDP phosphatase [EC:3.6.1.58]
D 110377263 deoxyuridine 5'-triphosphate nucleotidohydrolase K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 110371668 ribonucleoside-diphosphate reductase large subunit K10807 RRM1; ribonucleoside-diphosphate reductase subunit M1 [EC:1.17.4.1]
D 126053581 ribonucleoside-diphosphate reductase subunit M2 K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]
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AProkaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D 110372894 deoxyribodipyrimidine photo-lyase K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]
C BER (base exicision repair)
D DNA glycosylases
E 110378610 single-strand selective monofunctional uracil DNA glycosylase isoform X1 K10800 SMUG1; single-strand selective monofunctional uracil DNA glycosylase [EC:3.2.2.-]
E 110382804 DNA-3-methyladenine glycosylase 1-like K01246 tag; DNA-3-methyladenine glycosylase I [EC:3.2.2.20]
D AP endonucleases
D RecJ
D DNA ligase
D DNA polymerase I
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase complex (RNAP)
E TRCF (transcription-repair coupling factor)
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
D Molecular matchmaker
D Strand discrimination factor
D DNA exonucleases
D DNA polymerase III holoenzyme
D DNA ligase
D Other MMR factors
E 110377334 single-stranded DNA-binding protein, mitochondrial K03111 ssb; single-strand DNA-binding protein
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D RecBC pathway proteins
D RecFOR pathway proteins
D AddAB pathway proteins
D Other HR factor
D Archaeal homologous recombinant proteins
C NHEJ (non-homologous end-joining)
D Two-component NHEJ DNA repair complex
D SHIIR (short-homology-independent illegitimate recombination)
E Facilitator
E Supressor
D SHDIR (short-homology-dependent illegitimate recombination)
E RecET pathway
E Facilitator
E Supressor
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
C Other SOS response factors
D 110377334 single-stranded DNA-binding protein, mitochondrial K03111 ssb; single-strand DNA-binding protein
B Other factors with a suspected DNA repair function
C DNA polymerase
C DNA helicases
C Modulation of nucleotide pools
D 110377263 deoxyuridine 5'-triphosphate nucleotidohydrolase K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
C Others
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#
#[ BRITE | KEGG2 | KEGG ]
#Last updated: March 29, 2024