+F Repair protein KO
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DNA Repair and Recombination Proteins - Halyomorpha halys (brown marmorated stink bug)
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AEukaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D 106680828 DNA oxidative demethylase ALKBH2 K10859 ALKBH2; DNA oxidative demethylase [EC:1.14.11.33]
D 106678501 activating signal cointegrator 1 complex subunit 3 K18663 ASCC3; activating signal cointegrator complex subunit 3 [EC:5.6.2.4]
D 106678747 deoxyribodipyrimidine photo-lyase-like K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]
C BER (base exicision repair)
D DNA glycosylases
E 106692520 uncharacterized protein LOC106692520 K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E 106689665 G/T mismatch-specific thymine DNA glycosylase K20813 TDG; thymine-DNA glycosylase [EC:3.2.2.29]
E 106682041 uncharacterized protein LOC106682041 K20813 TDG; thymine-DNA glycosylase [EC:3.2.2.29]
E 106680858 DNA-3-methyladenine glycosylase K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]
E 106680894 DNA-3-methyladenine glycosylase-like K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]
E 106689943 single-strand selective monofunctional uracil DNA glycosylase isoform X1 K10800 SMUG1; single-strand selective monofunctional uracil DNA glycosylase [EC:3.2.2.-]
E 106679502 uncharacterized protein LOC106679502 K03660 OGG1; N-glycosylase/DNA lyase [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
E 106685927 DNA-(apurinic or apyrimidinic site) lyase K10771 APEX1; AP endonuclease 1 [EC:3.1.11.2]
D Long Patch-BER factors
E DNA polymerase delta complex
F 106690110 DNA polymerase delta catalytic subunit isoform X2 K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
F 106691420 DNA polymerase delta subunit 2 K02328 POLD2; DNA polymerase delta subunit 2
F 106688796 DNA polymerase delta subunit 3-like K03504 POLD3; DNA polymerase delta subunit 3
E DNA polymerase epsilon complex
F 106684386 DNA polymerase epsilon catalytic subunit A K02324 POLE; DNA polymerase epsilon subunit 1 [EC:2.7.7.7]
F 106677111 DNA polymerase epsilon subunit 2 K02325 POLE2; DNA polymerase epsilon subunit 2 [EC:2.7.7.7]
F 106691189 DNA polymerase epsilon subunit 3 K02326 POLE3; DNA polymerase epsilon subunit 3 [EC:2.7.7.7]
F 106684314 DNA polymerase epsilon subunit C-like K03506 POLE4; DNA polymerase epsilon subunit 4 [EC:2.7.7.7]
E 106680936 proliferating cell nuclear antigen-like isoform X1 K04802 PCNA; proliferating cell nuclear antigen
E 106687653 proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
E 106690627 flap endonuclease 1 K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
E 106692815 DNA ligase 1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
D Short Patch-BER factors
E 106684542 DNA polymerase beta-like K02330 POLB; DNA polymerase beta [EC:2.7.7.7 4.2.99.-]
E 106681562 DNA repair protein XRCC1-like K10803 XRCC1; DNA-repair protein XRCC1
E 106688132 DNA ligase 3 K10776 LIG3; DNA ligase 3 [EC:6.5.1.1]
D Other BER factors
E 106692342 probable tyrosyl-DNA phosphodiesterase isoform X1 K10862 TDP1; tyrosyl-DNA phosphodiesterase 1 [EC:3.1.4.-]
E 106692363 probable tyrosyl-DNA phosphodiesterase K10862 TDP1; tyrosyl-DNA phosphodiesterase 1 [EC:3.1.4.-]
E 106690133 aprataxin isoform X1 K10863 APTX; aprataxin [EC:3.6.1.70 3.6.1.71 3.6.1.72]
E 106689211 uncharacterized protein F21D5.5 K08073 PNKP; bifunctional polynucleotide phosphatase/kinase [EC:3.1.3.32 2.7.1.78]
E 106684208 uncharacterized protein F21D5.5-like K08073 PNKP; bifunctional polynucleotide phosphatase/kinase [EC:3.1.3.32 2.7.1.78]
E 106689649 poly [ADP-ribose] polymerase K24070 PARP1; poly [ADP-ribose] polymerase 1 [EC:2.4.2.30]
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E XPC-HR23B-CETN2 complex
F 106679659 DNA repair protein complementing XP-C cells K10838 XPC; xeroderma pigmentosum group C-complementing protein
F 106684148 UV excision repair protein RAD23 homolog B K10839 RAD23; UV excision repair protein RAD23
E Cul4-DDB2 complex
F 106682125 RING-box protein 1A K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
F 106690356 uncharacterized protein LOC106690356 K10609 CUL4; cullin 4
F 106683880 cullin-4A isoform X1 K10609 CUL4; cullin 4
F 106687896 DNA damage-binding protein 1 K10610 DDB1; DNA damage-binding protein 1
F 106683541 DNA damage-binding protein 2 K10140 DDB2; DNA damage-binding protein 2
F 112211555 DNA damage-binding protein 2-like K10140 DDB2; DNA damage-binding protein 2
E NER4 complex
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase II complex
F 106681893 DNA-directed RNA polymerase II subunit RPB1 K03006 RPB1; DNA-directed RNA polymerase II subunit RPB1 [EC:2.7.7.6]
F 106689535 DNA-directed RNA polymerase II subunit RPB2 K03010 RPB2; DNA-directed RNA polymerase II subunit RPB2 [EC:2.7.7.6]
F 106684605 DNA-directed RNA polymerase II subunit RPB3 K03011 RPB3; DNA-directed RNA polymerase II subunit RPB3
F 106689521 DNA-directed RNA polymerase II 16 kDa polypeptide isoform X1 K03012 RPB4; DNA-directed RNA polymerase II subunit RPB4
F 106686006 DNA-directed RNA polymerases I, II, and III subunit RPABC1 K03013 RPABC1; DNA-directed RNA polymerases I, II, and III subunit RPABC1
F 106677408 DNA-directed RNA polymerases I, II, and III subunit RPABC2 K03014 RPABC2; DNA-directed RNA polymerases I, II, and III subunit RPABC2
F 106678486 DNA-directed RNA polymerase II subunit RPB7 isoform X1 K03015 RPB7; DNA-directed RNA polymerase II subunit RPB7
F 106684035 DNA-directed RNA polymerases I, II, and III subunit RPABC3 K03016 RPABC3; DNA-directed RNA polymerases I, II, and III subunit RPABC3
F 106678623 DNA-directed RNA polymerase II subunit RPB9 K03017 RPB9; DNA-directed RNA polymerase II subunit RPB9
F 106683138 DNA-directed RNA polymerases I, II, and III subunit RPABC5 K03007 RPABC5; DNA-directed RNA polymerases I, II, and III subunit RPABC5
F 106688826 DNA-directed RNA polymerase II subunit RPB11 K03008 RPB11; DNA-directed RNA polymerase II subunit RPB11
F 106687978 DNA-directed RNA polymerases I, II, and III subunit RPABC4 K03009 RPABC4; DNA-directed RNA polymerases I, II, and III subunit RPABC4
E Cul4-CSA complex
F 106682125 RING-box protein 1A K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
F 106690356 uncharacterized protein LOC106690356 K10609 CUL4; cullin 4
F 106683880 cullin-4A isoform X1 K10609 CUL4; cullin 4
F 106687896 DNA damage-binding protein 1 K10610 DDB1; DNA damage-binding protein 1
F 106685063 DNA excision repair protein ERCC-8-like isoform X1 K10570 ERCC8; DNA excision repair protein ERCC-8
E Other TCR factor
F 106690616 DNA excision repair protein ERCC-6-like K10841 ERCC6; DNA excision repair protein ERCC-6
F 106685401 UV-stimulated scaffold protein A-like K23720 UVSSA; UV-stimulated scaffold protein A
F 106691216 transcription elongation factor 1 homolog K25829 ELOF1; transcription elongation factor 1
F 106677900 transcription elongation factor 1 homolog isoform X1 K25829 ELOF1; transcription elongation factor 1
D TFIIH complex
E 106682947 general transcription and DNA repair factor IIH helicase subunit XPB isoform X1 K10843 ERCC3; DNA excision repair protein ERCC-3 [EC:5.6.2.4]
E 106691291 general transcription and DNA repair factor IIH helicase subunit XPD K10844 ERCC2; DNA excision repair protein ERCC-2 [EC:5.6.2.3]
E 106680867 general transcription factor IIH subunit 1 K03141 TFIIH1; transcription initiation factor TFIIH subunit 1
E 106692850 general transcription factor IIH subunit 2 isoform X1 K03142 TFIIH2; transcription initiation factor TFIIH subunit 2
E 106683266 general transcription factor IIH subunit 3 isoform X1 K03143 TFIIH3; transcription initiation factor TFIIH subunit 3
E 106682789 general transcription factor IIH subunit 4 K03144 TFIIH4; transcription initiation factor TFIIH subunit 4
E 106689633 general transcription factor IIH subunit 5 K10845 TTDA; TFIIH basal transcription factor complex TTD-A subunit
E 106682412 cyclin-dependent kinase 7 K02202 CDK7; cyclin-dependent kinase 7 [EC:2.7.11.22 2.7.11.23]
E 106685016 cyclin-H K06634 CCNH; cyclin H
E 106684777 CDK-activating kinase assembly factor MAT1 K10842 MNAT1; CDK-activating kinase assembly factor MAT1
D RPA (replication factor A)
E 106678745 replication protein A 70 kDa DNA-binding subunit K07466 RFA1; replication factor A1
E 106690203 replication protein A 32 kDa subunit isoform X1 K10739 RFA2; replication factor A2
E 106686391 uncharacterized protein LOC106686391 K10740 RPA3; replication factor A3
D Other NER factors
E 106677423 DNA repair protein complementing XP-A cells homolog K10847 XPA; DNA-repair protein complementing XP-A cells
E 106681765 DNA excision repair protein ERCC-1 isoform X1 K10849 ERCC1; DNA excision repair protein ERCC-1
E 106689637 DNA repair endonuclease XPF K10848 ERCC4; DNA excision repair protein ERCC-4 [EC:3.1.-.-]
E 106685397 DNA repair protein complementing XP-G cells homolog K10846 ERCC5; DNA excision repair protein ERCC-5
E 106692815 DNA ligase 1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
E 106687704 MMS19 nucleotide excision repair protein homolog isoform X1 K15075 MET18; DNA repair/transcription protein MET18/MMS19
E 106688567 cullin-3-B isoform X1 K03869 CUL3; cullin 3
E 106679824 cullin-5 K10612 CUL5; cullin 5
E 106678597 elongin-C K03872 ELOC; elongin-C
E 106686507 uncharacterized protein LOC106686507 isoform X1 K03872 ELOC; elongin-C
E 106683174 uncharacterized protein LOC106683174 isoform X1 K03873 ELOB; elongin-B
E 106677858 elongin-B K03873 ELOB; elongin-B
E 106692478 transcription elongation factor B polypeptide 3 K15076 ELOA; elongin-A
E 106678680 protein lingerer isoform X1 K26545 UBAP2; ubiquitin-associated protein 2
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
E 106682669 DNA mismatch repair protein Msh2 K08735 MSH2; DNA mismatch repair protein MSH2
E 106681382 DNA mismatch repair protein Msh6 K08737 MSH6; DNA mismatch repair protein MSH6
D MutL homologs
E 106682288 PMS1 protein homolog 1-like K10864 PMS1; DNA mismatch repair protein PMS1
E 106687594 DNA mismatch repair protein Mlh1 K08734 MLH1; DNA mismatch repair protein MLH1
E 106677820 mismatch repair endonuclease PMS2 K10858 PMS2; DNA mismatch repair protein PMS2
D DNA polymerase delta complex
E 106690110 DNA polymerase delta catalytic subunit isoform X2 K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
E 106691420 DNA polymerase delta subunit 2 K02328 POLD2; DNA polymerase delta subunit 2
E 106688796 DNA polymerase delta subunit 3-like K03504 POLD3; DNA polymerase delta subunit 3
D RPA (replication factor A)
E 106678745 replication protein A 70 kDa DNA-binding subunit K07466 RFA1; replication factor A1
E 106690203 replication protein A 32 kDa subunit isoform X1 K10739 RFA2; replication factor A2
E 106686391 uncharacterized protein LOC106686391 K10740 RPA3; replication factor A3
D RFC (replication factor C)
E 106677077 replication factor C subunit 1 isoform X1 K10754 RFC1; replication factor C subunit 1
E 106682141 replication factor C subunit 4 isoform X1 K10755 RFC2_4; replication factor C subunit 2/4
E 106685172 replication factor C subunit 2 K10755 RFC2_4; replication factor C subunit 2/4
E 106682521 replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
E 106678169 replication factor C subunit 5 K10756 RFC3_5; replication factor C subunit 3/5
D Other MMR factors
E 106680936 proliferating cell nuclear antigen-like isoform X1 K04802 PCNA; proliferating cell nuclear antigen
E 106687653 proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
E 106691338 exonuclease 1 isoform X1 K10746 EXO1; exonuclease 1 [EC:3.1.-.-]
E 106692815 DNA ligase 1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
E 106691199 WD repeat-containing protein 76-like K24755 WDR76; WD repeat-containing protein 76
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D MRN(MRX) complex
E 106679363 double-strand break repair protein MRE11 K10865 MRE11; double-strand break repair protein MRE11
E 106690291 DNA repair protein RAD50 isoform X1 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
D BRCA1-core complex
E 106684839 BRCA1-associated RING domain protein 1-like K10683 BARD1; BRCA1-associated RING domain protein 1
D BRCA1-A complex
D BRCA1-B complex
E 106685282 DNA topoisomerase 2-binding protein 1 K10728 TOPBP1; topoisomerase (DNA) II binding protein 1
D BRCA1-C complex
E 106687941 uncharacterized protein LOC106687941 K20773 RBBP8; DNA endonuclease RBBP8 [EC:3.1.-.-]
E 106679363 double-strand break repair protein MRE11 K10865 MRE11; double-strand break repair protein MRE11
E 106690291 DNA repair protein RAD50 isoform X1 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
D BRCA complex
E 112211463 DNA repair protein RAD51 homolog 1-like K04482 RAD51; DNA repair protein RAD51
E 106684565 DNA repair protein RAD51 homolog 1 K04482 RAD51; DNA repair protein RAD51
D RecA family proteins
E 112211463 DNA repair protein RAD51 homolog 1-like K04482 RAD51; DNA repair protein RAD51
E 106684565 DNA repair protein RAD51 homolog 1 K04482 RAD51; DNA repair protein RAD51
E 106677564 DNA repair protein RAD51 homolog 3-like isoform X1 K10870 RAD51L2; RAD51-like protein 2
E 106692299 DNA repair protein RAD51 homolog 4 K10871 RAD51L3; RAD51-like protein 3
E 112210183 DNA repair protein XRCC2-like K10879 XRCC2; DNA-repair protein XRCC2
E 106678394 DNA repair protein XRCC3 K10880 XRCC3; DNA-repair protein XRCC3
D Rad52 family proteins
D Rad54 family proteins
E 106684147 DNA repair and recombination protein RAD54-like isoform X1 K10875 RAD54L; DNA repair and recombination protein RAD54 and RAD54-like protein [EC:5.6.2.-]
E 106680423 DNA repair and recombination protein RAD54B-like K10877 RAD54B; DNA repair and recombination protein RAD54B [EC:5.6.2.-]
D RecQ family DNA helicases
E 106690849 Werner syndrome ATP-dependent helicase K10900 WRN; werner syndrome ATP-dependent helicase [EC:5.6.2.4]
E 106691746 Bloom syndrome protein homolog isoform X1 K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 106691194 ATP-dependent DNA helicase Q4 K10730 RECQL4; ATP-dependent DNA helicase Q4 [EC:5.6.2.4]
E 106689167 ATP-dependent DNA helicase Q5-like K10902 RECQL5; ATP-dependent DNA helicase Q5 [EC:5.6.2.4]
D Bloom's syndrome complex (BTR)
E 106691746 Bloom syndrome protein homolog isoform X1 K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 106691290 DNA topoisomerase 3-beta-1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 106677268 DNA topoisomerase 3-alpha K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 106686873 recQ-mediated genome instability protein 1-like K10990 RMI1; RecQ-mediated genome instability protein 1
D RPA (replication factor A)
E 106678745 replication protein A 70 kDa DNA-binding subunit K07466 RFA1; replication factor A1
E 106690203 replication protein A 32 kDa subunit isoform X1 K10739 RFA2; replication factor A2
E 106686391 uncharacterized protein LOC106686391 K10740 RPA3; replication factor A3
D Protein phosphatase 4
E 106679294 serine/threonine-protein phosphatase PP-X isozyme 2-like K15423 PPP4C; serine/threonine-protein phosphatase 4 catalytic subunit [EC:3.1.3.16]
E 106687319 serine/threonine-protein phosphatase 4 catalytic subunit isoform X1 K15423 PPP4C; serine/threonine-protein phosphatase 4 catalytic subunit [EC:3.1.3.16]
E 106680185 serine/threonine-protein phosphatase 4 regulatory subunit 1-like isoform X1 K15424 PPP4R1; serine/threonine-protein phosphatase 4 regulatory subunit 1
E 106689471 serine/threonine-protein phosphatase 4 regulatory subunit 2 K15425 PPP4R2; serine/threonine-protein phosphatase 4 regulatory subunit 2
E 106691506 serine/threonine-protein phosphatase 4 regulatory subunit 2 K15425 PPP4R2; serine/threonine-protein phosphatase 4 regulatory subunit 2
E 106692297 serine/threonine-protein phosphatase 4 regulatory subunit 2-like K15425 PPP4R2; serine/threonine-protein phosphatase 4 regulatory subunit 2
E 106688110 serine/threonine-protein phosphatase 4 regulatory subunit 3-like K17491 SMEK; protein phosphatase 4 regulatory subunit 3
E 106693026 serine/threonine-protein phosphatase 4 regulatory subunit 4-like isoform X3 K15426 PPP4R4; serine/threonine-protein phosphatase 4 regulatory subunit 4
D AP-5 complex
D SMC5-SMC6 complex
E 106678548 structural maintenance of chromosomes protein 5 isoform X1 K22803 SMC5; structural maintenance of chromosomes protein 5
E 106685628 structural maintenance of chromosomes protein 6-like K22804 SMC6; structural maintenance of chromosomes protein 6
E 106680597 non-structural maintenance of chromosomes element 1 homolog K22817 NSMCE1; non-structural maintenance of chromosomes element 1 [EC:2.3.2.27]
E 106677501 melanoma-associated antigen D2-like K22823 NSMCE3; non-structural maintenance of chromosomes element 3
E 106692923 uncharacterized protein LOC106692923 isoform X1 K22825 NSMCE4; non-structural maintenance of chromosomes element 4
D Other HR factors
E 106682494 crossover junction endonuclease MUS81 K08991 MUS81; crossover junction endonuclease MUS81 [EC:3.1.22.-]
E 106692674 structure-specific endonuclease subunit slx1 K15078 SLX1; structure-specific endonuclease subunit SLX1 [EC:3.6.1.-]
E 106687069 flap endonuclease GEN K15338 GEN1; holliday junction resolvase GEN1/YEN1 [EC:3.1.-.-]
E 106690894 mortality factor 4-like protein 1 K11339 MORF4L1; mortality factor 4-like protein 1
E 106689818 deoxynucleoside triphosphate triphosphohydrolase SAMHD1 isoform X1 K22544 SAMHD1; deoxynucleoside triphosphate triphosphohydrolase SAMHD1 [EC:3.1.5.-]
E 106684143 fidgetin-like protein 1 K22766 FIGNL1; fidgetin-like protein 1 [EC:5.6.2.-]
E 106679378 uncharacterized protein LOC106679378 isoform X1 K23112 BRAT1; BRCA1-associated ATM activator 1
E 106679380 uncharacterized protein LOC106679380 K23112 BRAT1; BRCA1-associated ATM activator 1
E 106681244 uncharacterized protein F09G8.5 isoform X1 K23456 CFAP410; cilla- and flagella-associated protein
E 106691019 heat shock factor 2-binding protein-like isoform X1 K25791 HSF2BP; heat shock factor 2-binding protein
E 106689109 protein MMS22-like K26125 MMS22L; protein MMS22-like
E 106681088 tonsoku-like protein K09257 NFKBIL2; NF-kappa-B inhibitor-like protein 2
E 106677994 biorientation of chromosomes in cell division protein 1-like 1 isoform X1 K27262 BOD1L1; biorientation of chromosomes in cell division protein 1-like 1
E 106685867 Werner Syndrome-like exonuclease K22807 WRNexo; werner syndrome-like exonuclease [EC:3.1.11.-]
C NHEJ (non-homologous end-joining)
D DNA-PK complex
E 106680520 X-ray repair cross-complementing protein 5-like K10884 XRCC6; ATP-dependent DNA helicase 2 subunit 1
E 106689919 X-ray repair cross-complementing protein 5-like K10885 XRCC5; ATP-dependent DNA helicase 2 subunit 2
D MRX complex
E 106679363 double-strand break repair protein MRE11 K10865 MRE11; double-strand break repair protein MRE11
E 106690291 DNA repair protein RAD50 isoform X1 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
D DNA Ligase 4 complex
E 106682730 DNA ligase 4 K10777 LIG4; DNA ligase 4 [EC:6.5.1.1]
E 106690342 DNA repair protein XRCC4-like K10886 XRCC4; DNA-repair protein XRCC4
D X-family DNA polymerases
E 106684542 DNA polymerase beta-like K02330 POLB; DNA polymerase beta [EC:2.7.7.7 4.2.99.-]
D Other NHEJ factors
E 106690133 aprataxin isoform X1 K10863 APTX; aprataxin [EC:3.6.1.70 3.6.1.71 3.6.1.72]
C FA (Fanconi anemia) pathway
D FA core complex
E 106677185 E3 ubiquitin-protein ligase FANCL isoform X1 K10606 FANCL; E3 ubiquitin-protein ligase FANCL [EC:2.3.2.27]
E 106679460 Fanconi anemia group M protein K10896 FANCM; fanconi anemia group M protein
D FA core complex binding factors
E 106692578 centromere protein S-like K11511 APITD1; centromere protein S
E 106684485 centromere protein X-like K15360 STRA13; centromere protein X
E 106690157 ubiquitin-conjugating enzyme E2 T-like K13960 UBE2T; ubiquitin-conjugating enzyme E2 T [EC:2.3.2.23]
D Bloom's syndrome complex (BTR)
E 106691746 Bloom syndrome protein homolog isoform X1 K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 106691290 DNA topoisomerase 3-beta-1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 106677268 DNA topoisomerase 3-alpha K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 106686873 recQ-mediated genome instability protein 1-like K10990 RMI1; RecQ-mediated genome instability protein 1
D FANCD2-I complex
E 106679192 Fanconi anemia group D2 protein K10891 FANCD2; fanconi anemia group D2 protein
E 106683401 Fanconi anemia group I protein isoform X1 K10895 FANCI; fanconi anemia group I protein
D Downstream FA components
D Other FA pathway factors
E 106677663 fanconi-associated nuclease 1-like K15363 FAN1; fanconi-associated nuclease 1 [EC:3.1.21.- 3.1.4.1]
E 112211463 DNA repair protein RAD51 homolog 1-like K04482 RAD51; DNA repair protein RAD51
E 106684565 DNA repair protein RAD51 homolog 1 K04482 RAD51; DNA repair protein RAD51
E 106677564 DNA repair protein RAD51 homolog 3-like isoform X1 K10870 RAD51L2; RAD51-like protein 2
E 106691381 ubiquitin carboxyl-terminal hydrolase 1 isoform X1 K11832 USP1; ubiquitin carboxyl-terminal hydrolase 1 [EC:3.4.19.12]
E 106691528 WD repeat-containing protein 48 K15361 WDR48; WD repeat-containing protein 48
C Other DSBR factors
D Protein phosphatase 6
E 106687288 serine/threonine-protein phosphatase 6 catalytic subunit K15498 PPP6C; serine/threonine-protein phosphatase 6 catalytic subunit [EC:3.1.3.16]
D Ubiquitin ligases
E 106680436 E3 ubiquitin-protein ligase rnf8-B K10667 RNF8; E3 ubiquitin-protein ligase RNF8 [EC:2.3.2.27]
E 106681034 E3 ubiquitin-protein ligase rnf168 K20805 RNF169; E3 ubiquitin-protein ligase RNF169 [EC:2.3.2.31]
E 106684838 E3 ubiquitin-protein ligase HERC2 isoform X1 K10595 HERC2; E3 ubiquitin-protein ligase HERC2 [EC:2.3.2.26]
D Others
E 106678052 telomerase Cajal body protein 1 isoform X1 K23314 WRAP53; telomerase Cajal body protein 1
E 106679494 gastrulation defective protein 1 homolog K24752 WDR70; WD repeat-containing protein 70
E 106691199 WD repeat-containing protein 76-like K24755 WDR76; WD repeat-containing protein 76
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
D 106687406 DNA polymerase eta isoform X1 K03509 POLH; DNA polymerase eta [EC:2.7.7.7]
D 106684988 DNA repair protein REV1 K03515 REV1; DNA repair protein REV1 [EC:2.7.7.-]
C B-family DNA polymerases
D 106680812 DNA polymerase zeta catalytic subunit isoform X1 K02350 REV3L; DNA polymerase zeta [EC:2.7.7.7]
C A-family DNA polymerase
D 106683532 DNA polymerase nu-like isoform X1 K16618 POLN; DNA polymerase nu [EC:2.7.7.7]
C Rad6 epistasis group
D 106678823 ubiquitin-conjugating enzyme E2 A-like K10573 UBE2A; ubiquitin-conjugating enzyme E2 A [EC:2.3.2.23]
D 106691753 ubiquitin-conjugating enzyme E2-17 kDa K10573 UBE2A; ubiquitin-conjugating enzyme E2 A [EC:2.3.2.23]
D 106684420 ubiquitin-conjugating enzyme E2-17 kDa-like K10573 UBE2A; ubiquitin-conjugating enzyme E2 A [EC:2.3.2.23]
D 106684419 ubiquitin-conjugating enzyme E2-17 kDa-like K10573 UBE2A; ubiquitin-conjugating enzyme E2 A [EC:2.3.2.23]
D 106687557 E3 ubiquitin-protein ligase RAD18-like K10627 RAD18; E3 ubiquitin-protein ligase RAD18 [EC:2.3.2.27]
D 106681072 ubiquitin-conjugating enzyme E2 variant 2 isoform X1 K10704 UBE2V; ubiquitin-conjugating enzyme E2 variant
D 106690180 ubiquitin-conjugating enzyme E2 N K10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23]
C Other TLS factors
D 106680936 proliferating cell nuclear antigen-like isoform X1 K04802 PCNA; proliferating cell nuclear antigen
D 106687653 proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
D 106678235 sprT-like domain-containing protein Spartan isoform X1 K24051 SPRTN; SprT-like domain-contaning protein Spartan
D 106688365 homeobox protein 2 K26957 GCNA; germ cell nuclear acidic protein
B Check point factors
C Rad9-Hus1-Rad1 complex
D 106690759 cell cycle checkpoint control protein RAD9A K10994 RAD9A; cell cycle checkpoint control protein RAD9A [EC:3.1.11.2]
D 106689371 checkpoint protein HUS1 isoform X1 K10903 HUS1; HUS1 checkpoint protein
D 106690338 cell cycle checkpoint protein RAD1-like K02830 HRAD1; cell cycle checkpoint protein [EC:3.1.11.2]
C HRAD17(Rad24)-RFC complex
D 106685923 cell cycle checkpoint protein RAD17 K06662 HRAD17; cell cycle checkpoint protein
D 106682141 replication factor C subunit 4 isoform X1 K10755 RFC2_4; replication factor C subunit 2/4
D 106685172 replication factor C subunit 2 K10755 RFC2_4; replication factor C subunit 2/4
D 106682521 replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
D 106678169 replication factor C subunit 5 K10756 RFC3_5; replication factor C subunit 3/5
C Rad17-Mec3-Ddc1 complex
D 106690338 cell cycle checkpoint protein RAD1-like K02830 HRAD1; cell cycle checkpoint protein [EC:3.1.11.2]
C FPC (fork protection complex)
D 106683596 protein timeless homolog K10997 TIMELESS; replication fork protection complex subunit TIMELESS/Tof1/Swi1
D 106692501 TIMELESS-interacting protein K10998 TIPIN; replication fork protection complex subunit TIPIN/Csm3/Swi3
D 106680202 claspin K25773 CLSPN; claspin
C Triple T complex
D 106681294 TELO2-interacting protein 1 homolog K20403 TTI1; TELO2-interacting protein 1
D 106691042 TELO2-interacting protein 2-like K23115 TTI2; TELO2-interacting protein 2
C BAG6-UBL4A-GET4 complex
D 106684392 large proline-rich protein BAG6 isoform X1 K23390 BAG6; large proline-rich protein BAG6
D 106685049 ubiquitin-like protein 4A K23388 UBL4; ubiquitin-like protein 4
D 106688577 Golgi to ER traffic protein 4 homolog K23387 GET4; golgi to ER traffic protein 4
C Other check point factors
D 106684723 serine/threonine-protein kinase ATR isoform X1 K06640 ATR; serine/threonine-protein kinase ATR [EC:2.7.11.1]
D 106683940 serine-protein kinase ATM K04728 ATM; serine-protein kinase ATM [EC:2.7.11.1]
D 106678732 serine/threonine-protein kinase grp K02216 CHEK1; serine/threonine-protein kinase CHEK1 [EC:2.7.11.1]
D 106678371 ovarian-specific serine/threonine-protein kinase Lok K06641 CHEK2; serine/threonine-protein kinase CHEK2 [EC:2.7.11.1]
D 106685042 M-phase inducer phosphatase isoform X1 K06645 CDC25A; M-phase inducer phosphatase 1 [EC:3.1.3.48]
D 106687984 14-3-3 protein zeta isoform X1 K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
D 106682846 14-3-3 protein epsilon K06630 YWHAE; 14-3-3 protein epsilon
D 106681184 wee1-like protein kinase K06632 WEE1; wee1-like protein kinase [EC:2.7.11.1]
D 106686423 period circadian protein isoform X1 K02633 PER2; period circadian protein 2
D 106688209 plastin-2 K17336 PLS3; plastin-3
D 106689766 protein downstream neighbor of son homolog isoform X1 K22422 DONSON; protein downstream neighbor of Son
D 106690958 uncharacterized protein LOC106690958 isoform X1 K22808 KANK; KN motif and ankyrin repeat domain-containing protein
D 106679393 vacuolar protein sorting-associated protein 4A K12196 VPS4; vacuolar protein-sorting-associated protein 4
D 106692817 suppressor protein of bem1/bed5 double mutants-like K12196 VPS4; vacuolar protein-sorting-associated protein 4
D 106680199 replication stress response regulator SDE2 K25059 SDE2; replication stress response regulator SDE2
B Other factors with a suspected DNA repair function
C DNA polymerases
D 106687388 DNA polymerase theta-like isoform X1 K02349 POLQ; DNA polymerase theta [EC:2.7.7.7]
D 106681194 uncharacterized protein LOC106681194 K02331 POL5; DNA polymerase phi [EC:2.7.7.7]
D 106681066 DNA-directed primase/polymerase protein-like K22761 PRIMPOL; DNA-directed primase/polymerase protein [EC:2.7.7.102 2.7.7.7]
C Nucleases
D 106677796 uncharacterized protein LOC106677796 K10791 TREX2; three prime repair exonuclease 2 [EC:3.1.11.2]
D 106677068 5' exonuclease Apollo-like K15341 DCLRE1B; DNA cross-link repair 1B protein [EC:3.1.-.-]
D 106677686 ankyrin repeat and LEM domain-containing protein 1-like K21411 ANKLE1; ankyrin repeat and LEM domain-containing protein 1
C Helicases
D 106678675 helicase POLQ-like K19178 HELQ; POLQ-like helicase [EC:5.6.2.4]
C PSO4 complex
D 106692806 pre-mRNA-processing factor 19 K10599 PRPF19; pre-mRNA-processing factor 19 [EC:2.3.2.27]
D 106682174 cell division cycle 5-like protein K12860 CDC5L; pre-mRNA-splicing factor CDC5/CEF1
D 106688896 pre-mRNA-splicing factor SPF27 K12861 BCAS2; pre-mRNA-splicing factor SPF27
D 106678479 pleiotropic regulator 1 K12862 PLRG1; pleiotropic regulator 1
C Modulation of nucleotide pools
D 106677168 7,8-dihydro-8-oxoguanine triphosphatase K17816 NUDT1; 8-oxo-dGTP diphosphatase / 2-hydroxy-dATP diphosphatase [EC:3.6.1.55 3.6.1.56]
D 106686903 8-oxo-dGDP phosphatase NUDT18 K17817 NUDT18; 8-oxo-dGDP phosphatase [EC:3.6.1.58]
D 106680777 deoxyuridine 5'-triphosphate nucleotidohydrolase K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 106691597 ribonucleoside-diphosphate reductase large subunit K10807 RRM1; ribonucleoside-diphosphate reductase subunit M1 [EC:1.17.4.1]
D 106692356 ribonucleoside-diphosphate reductase subunit M2 B isoform X1 K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]
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AProkaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D 106678747 deoxyribodipyrimidine photo-lyase-like K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]
C BER (base exicision repair)
D DNA glycosylases
E 106692520 uncharacterized protein LOC106692520 K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E 106689943 single-strand selective monofunctional uracil DNA glycosylase isoform X1 K10800 SMUG1; single-strand selective monofunctional uracil DNA glycosylase [EC:3.2.2.-]
E 106680858 DNA-3-methyladenine glycosylase K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]
E 106680894 DNA-3-methyladenine glycosylase-like K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]
D AP endonucleases
D RecJ
D DNA ligase
D DNA polymerase I
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase complex (RNAP)
E TRCF (transcription-repair coupling factor)
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
D Molecular matchmaker
D Strand discrimination factor
D DNA exonucleases
D DNA polymerase III holoenzyme
D DNA ligase
D Other MMR factors
E 106682245 single-stranded DNA-binding protein, mitochondrial K03111 ssb; single-strand DNA-binding protein
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D RecBC pathway proteins
D RecFOR pathway proteins
D AddAB pathway proteins
D Other HR factor
D Archaeal homologous recombinant proteins
C NHEJ (non-homologous end-joining)
D Two-component NHEJ DNA repair complex
D SHIIR (short-homology-independent illegitimate recombination)
E Facilitator
E Supressor
D SHDIR (short-homology-dependent illegitimate recombination)
E RecET pathway
E Facilitator
E Supressor
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
C Other SOS response factors
D 106682245 single-stranded DNA-binding protein, mitochondrial K03111 ssb; single-strand DNA-binding protein
B Other factors with a suspected DNA repair function
C DNA polymerase
C DNA helicases
C Modulation of nucleotide pools
D 106680777 deoxyuridine 5'-triphosphate nucleotidohydrolase K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
C Others
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: March 29, 2024