+F Cytoskeleton KO
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Cytoskeleton Proteins - Hermetia illucens (black soldier fly)
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AEukaryotic cytoskeleton proteins
B Actin filaments / Microfilaments
C Actins
D Actins
E 119646467 actin-5C K05692 ACTB_G1; actin beta/gamma 1
D Actin-related proteins
E 119659313 actin-related protein 1 K16575 ACTR1; centractin
E 119649737 actin-related protein 6 K11662 ACTR6; actin-related protein 6
E 119653719 actin-related protein 10 K16576 ACTR10; actin-related protein 10
C Actin-binding proteins
D Myosins
E 119647851 unconventional myosin IC isoform X1 K10356 MYO1; myosin I
E 119650845 unconventional myosin ID K10356 MYO1; myosin I
E 119651505 unconventional myosin-Ib isoform X1 K10356 MYO1; myosin I
E 119647045 neither inactivation nor afterpotential protein C K08834 MYO3; myosin III [EC:2.7.11.1]
E 119654331 myosin-IIIb-like K08834 MYO3; myosin III [EC:2.7.11.1]
E 119648738 unconventional myosin-Va isoform X1 K10357 MYO5; myosin V
E 119650662 myosin heavy chain 95F isoform X1 K10358 MYO6; myosin VI
E 119650957 myosin-VIIa isoform X1 K10359 MYO7A; myosin VIIa
E 119653923 myosin-VIIa-like K10359 MYO7A; myosin VIIa
E 119653402 unconventional myosin-XV isoform X1 K10361 MYO15; myosin XV
E 119659689 unconventional myosin-XVIIIa isoform X1 K10362 MYO18; myosin XVIII
E 119650735 myosin heavy chain, muscle isoform X1 K17751 MYH6_7; myosin heavy chain 6/7
E 119661747 myosin heavy chain, non-muscle isoform X1 K10352 MYH9s; myosin heavy chain 9/10/11/14
E 119661706 myosin-2 essential light chain isoform X1 K12751 MYL6; myosin light chain 6
E 119652909 myosin regulatory light chain sqh K12757 MYL12; myosin regulatory light chain 12
D Arp2/3 complex
E 119651011 actin-related protein 2/3 complex subunit 1A-B K05757 ARPC1A_B; actin related protein 2/3 complex, subunit 1A/1B
E 119650877 actin-related protein 2/3 complex subunit 2 K05758 ARPC2; actin related protein 2/3 complex, subunit 2
E 119659049 actin-related protein 2/3 complex subunit 3 K05756 ARPC3; actin related protein 2/3 complex, subunit 3
E 119649850 actin-related protein 2/3 complex subunit 4 K05755 ARPC4; actin related protein 2/3 complex, subunit 4
E 119656067 actin-related protein 2/3 complex subunit 5 K05754 ARPC5; actin related protein 2/3 complex, subunit 5
E 119657373 actin-related protein 2 isoform X1 K17260 ACTR2; actin-related protein 2
E 119648149 actin-related protein 3 K18584 ACTR3; actin-related protein 3
D WASP / WAVE
E 119657431 neural Wiskott-Aldrich syndrome protein K23612 WASL; neural Wiskott-Aldrich syndrome protein
E 119650459 wiskott-Aldrich syndrome protein family member 3 isoform X1 K06083 WASF3; WAS protein family, member 3
D Formins
E 119654370 disheveled-associated activator of morphogenesis 1 isoform X1 K04512 DAAM; dishevelled associated activator of morphogenesis
E 119647494 formin-like protein K23957 FMNL; formic-like protein
E 119650333 LOW QUALITY PROTEIN: formin-J K23958 INF2; inverted formin-2
D Profilin
E 119653215 profilin K05759 PFN; profilin
D Thymosin
D ADF / Cofilin
E 119653635 cofilin/actin-depolymerizing factor homolog K05765 CFL; cofilin
E SCMC complex
F 119659152 protein groucho isoform X1 K04497 GRO; groucho
F 119653689 protein groucho-like K04497 GRO; groucho
D Gelsolin / villin
E 119658964 gelsolin isoform X1 K05768 GSN; gelsolin
E 119655464 protein flightless-1 K27496 FLII; flightless I actin remodeling protein
D Ezrin/Radixin/Moesin
E 119655410 moesin/ezrin/radixin homolog 2 K16684 NF2; merlin
E 119658230 moesin/ezrin/radixin homolog 1 K26219 MOE; ezrin-moesin-radixin 1
D Capping proteins
E 119658945 F-actin-capping protein subunit alpha K10364 CAPZA; F-actin-capping protein subunit alpha
E 119661333 F-actin-capping protein subunit beta K10365 CAPZB; F-actin-capping protein subunit beta
E 119657652 tropomodulin isoform X1 K10370 TMOD; tropomodulin
D Tropomyosins
E 119658706 tropomyosin-1 isoform X1 K10374 TPM2; tropomyosin 2
D Troponins
E 119656489 troponin T, skeletal muscle isoform X1 K12046 TNNT3; troponin T, fast skeletal muscle
D Cross-linking proteins
E 119656077 alpha-actinin, sarcomeric isoform X1 K05699 ACTN1_4; actinin alpha 1/4
E 119656807 catenin alpha isoform X1 K05691 CTNNA; catenin alpha
E 119651104 filamin-A isoform X1 K04437 FLNA; filamin-A
E 119651425 filamin-B K04437 FLNA; filamin-A
E 119647100 filamin-C isoform X1 K04437 FLNA; filamin-A
E 119649621 spectrin alpha chain isoform X1 K06114 SPTAN; spectrin alpha, non-erythrocytic (fodrin)
E 119647505 spectrin beta chain, non-erythrocytic 1 isoform X1 K06115 SPTBN1_4_5; spectrin beta, non-erythrocytic 1/4/5
E 119655729 spectrin beta chain isoform X1 K06115 SPTBN1_4_5; spectrin beta, non-erythrocytic 1/4/5
E 119656194 patronin isoform X1 K17493 CAMSAP; calmodulin-regulated spectrin-associated protein
E 119661022 vinculin K05700 VCL; vinculin
E 119657356 protein singed K23551 FSCN1; fascin 1
E 119647725 uncharacterized protein LOC119647725 isoform X1 K17551 PPP1R9; neurabin
E 119653533 coronin-6 isoform X1 K13886 CORO1B_1C_6; coronin-1B/1C/6
E 119648077 coronin-2B-like isoform X1 K13887 CORO2; coronin-2
E 119656701 coronin-7 isoform X1 K18619 CORO7; coronin-7
D Others
E 119646410 anillin isoform X1 K18621 ANLN; actin-binding protein anillin
E 119655218 protein hu-li tai shao isoform X1 K18622 ADD; adducin
E 119659523 src substrate cortactin K06106 CTTN; cortactin
E 119649636 hemicentin-1 isoform X1 K16680 ED; echinoid
E 119652806 E3 ubiquitin-protein transferase MAEA K18624 MAEA; macrophage erythroblast attacher
E 119648566 beta-parvin isoform X1 K06275 PARV; parvin
E 119656486 plastin-1 isoform X1 K17336 PLS3; plastin-3
E 119659142 tight junction protein ZO-1 isoform X1 K05701 TJP1; tight junction protein 1
E 119647649 LOW QUALITY PROTEIN: titin-like K12567 TTN; titin [EC:2.7.11.1]
E 119654623 actin-histidine N-methyltransferase K19199 SETD3; protein-histidine N-methyltransferase [EC:2.1.1.85]
E 119657940 UPF0692 protein CG33108 K26539 ACTMAP; actin maturation protease [EC:3.4.11.-]
B Intermediate filaments
C Intermediate filaments
D Types I and II: Acidic and basic keratins
D Type III
D Type IV
D Type V: Nuclear lamins
E 119660785 lamin Dm0-like isoform X1 K07611 LMNB; lamin B
D Type VI
D Others
C Intermediate filament-binding proteins
D 119648082 ankyrin-3 K09255 ANK2; ankyrin-2
D 119661039 ankyrin-3 isoform X1 K09255 ANK2; ankyrin-2
D 119653756 uncharacterized protein LOC119653756 isoform X1 K10382 DST; dystonin
D 119651104 filamin-A isoform X1 K04437 FLNA; filamin-A
D 119651425 filamin-B K04437 FLNA; filamin-A
D 119647100 filamin-C isoform X1 K04437 FLNA; filamin-A
D 119649621 spectrin alpha chain isoform X1 K06114 SPTAN; spectrin alpha, non-erythrocytic (fodrin)
D 119647505 spectrin beta chain, non-erythrocytic 1 isoform X1 K06115 SPTBN1_4_5; spectrin beta, non-erythrocytic 1/4/5
D 119655729 spectrin beta chain isoform X1 K06115 SPTBN1_4_5; spectrin beta, non-erythrocytic 1/4/5
D 119656194 patronin isoform X1 K17493 CAMSAP; calmodulin-regulated spectrin-associated protein
B Microtubules
C Tubulins
D 119658781 tubulin alpha-1 chain isoform X1 K07374 TUBA; tubulin alpha
D 119648411 tubulin alpha-8 chain K07374 TUBA; tubulin alpha
D 119660494 tubulin alpha-8 chain-like K07374 TUBA; tubulin alpha
D 119651268 tubulin alpha-1A chain K07374 TUBA; tubulin alpha
D 119653821 tubulin alpha-1 chain K07374 TUBA; tubulin alpha
D 119651420 tubulin beta chain-like K07375 TUBB; tubulin beta
D 119651525 tubulin beta-2 chain K07375 TUBB; tubulin beta
D 119651581 tubulin beta chain-like K07375 TUBB; tubulin beta
D 119653260 tubulin beta chain-like K07375 TUBB; tubulin beta
D 119655171 tubulin beta-1 chain K07375 TUBB; tubulin beta
D 119656266 tubulin beta-3 chain K07375 TUBB; tubulin beta
D 119656868 tubulin beta chain-like K07375 TUBB; tubulin beta
D 119651374 tubulin gamma-1 chain K10389 TUBG; tubulin gamma
C Tubulin-binding proteins
D Kinesins
E 119656303 LOW QUALITY PROTEIN: kinesin-like protein unc-104 K10392 KIF1; kinesin family member 1
E 119656830 kinesin-like protein Klp10A isoform X1 K10393 KIF2_24; kinesin family member 2/24
E 119648687 kinesin-like protein KIF3A K10394 KIF3A; kinesin family member 3A
E 119654933 kinesin-like protein Klp68D K20196 KIF3B; kinesin family member 3B
E 119658496 chromosome-associated kinesin KIF4 K10395 KIF4; kinesin family member 4
E 119658240 kinesin heavy chain K10396 KIF5; kinesin family member 5
E 119650340 kinesin-like protein Klp61F K10398 KIF11; kinesin family member 11
E 119661105 kinesin-like protein KIF13B isoform X1 K17914 KIF13; kinesin family member 13
E 119647316 kinesin-like protein KIF14 K17915 KIF14; kinesin family member 14
E 119651150 kinesin-like protein Klp98A isoform X1 K17916 KIF16B; kinesin family member 16B
E 119661006 osmotic avoidance abnormal protein 3 isoform X1 K20198 KIF17; kinesin family member 17
E 119649755 kinesin-like protein KIF18A isoform X1 K10401 KIF18A; kinesin family member 18A
E 119653146 kinesin-like protein KIF19 isoform X1 K26157 KIF19; kinesin family member 19
E 119659735 kinesin-like protein subito K10402 KIF20; kinesin family member 20
E 119652225 kinesin-like protein KIF21A isoform X1 K24185 KIF21; kinesin family member 21
E 119650348 kinesin-like protein KIF23 isoform X1 K17387 KIF23; kinesin family member 23
E 119646889 kinesin-like protein CG14535 isoform X1 K10404 KIF26; kinesin family member 26
E 119653025 protein claret segregational K10405 KIFC1; kinesin family member C1
E 119650402 kinesin light chain isoform X1 K10407 KLC; kinesin light chain
D Stathmin
E 119651033 chromosome partition protein Smc isoform X1 K04381 STMN1; stathmin 1
D Microtubule severing proteins
E 119659176 katanin p60 ATPase-containing subunit A-like 1 K07767 KATNA1; katanin p60 ATPase-containing subunit A1 [EC:5.6.1.1]
E 119660492 katanin p60 ATPase-containing subunit A-like 1 isoform X1 K07767 KATNA1; katanin p60 ATPase-containing subunit A1 [EC:5.6.1.1]
E 119653401 katanin p60 ATPase-containing subunit A-like 2 K07767 KATNA1; katanin p60 ATPase-containing subunit A1 [EC:5.6.1.1]
E 119657409 katanin p80 WD40 repeat-containing subunit B1 K18643 KATNB1; katanin p80 WD40 repeat-containing subunit B1
E 119651944 spastin isoform X1 K13254 SPAST; spastin [EC:5.6.1.1]
D EMAP
E 119650294 echinoderm microtubule-associated protein-like CG42247 isoform X1 K18595 EML1_2; echinoderm microtubule-associated protein-like 1/2
E 119653573 echinoderm microtubule-associated protein-like 2 isoform X1 K18595 EML1_2; echinoderm microtubule-associated protein-like 1/2
D Dyneins
E 119646771 dynein heavy chain 2, axonemal K10408 DNAH; dynein axonemal heavy chain
E 119646987 dynein heavy chain 8, axonemal K10408 DNAH; dynein axonemal heavy chain
E 119647098 dynein heavy chain 6, axonemal K10408 DNAH; dynein axonemal heavy chain
E 119648551 dynein heavy chain 12, axonemal-like K10408 DNAH; dynein axonemal heavy chain
E 119648552 dynein heavy chain 12, axonemal-like K10408 DNAH; dynein axonemal heavy chain
E 119660242 dynein heavy chain 5, axonemal isoform X1 K10408 DNAH; dynein axonemal heavy chain
E 119660274 dynein beta chain, ciliary isoform X1 K10408 DNAH; dynein axonemal heavy chain
E 119650366 dynein heavy chain 3, axonemal K10408 DNAH; dynein axonemal heavy chain
E 119652057 dynein beta chain, ciliary-like K10408 DNAH; dynein axonemal heavy chain
E 119652058 LOW QUALITY PROTEIN: dynein heavy chain 10, axonemal K10408 DNAH; dynein axonemal heavy chain
E 119652125 dynein heavy chain 7, axonemal K10408 DNAH; dynein axonemal heavy chain
E 119652359 dynein beta chain, ciliary isoform X1 K10408 DNAH; dynein axonemal heavy chain
E 119646995 dynein intermediate chain 2, ciliary isoform X1 K10409 DNAI1; dynein axonemal intermediate chain 1
E 119649230 dynein intermediate chain 3, ciliary isoform X1 K11143 DNAI2; dynein axonemal intermediate chain 2
E 119649411 dynein intermediate chain 4, axonemal K24723 DNAI4; dynein axonemal intermediate chain 4
E 119659655 putative inner dynein arm light chain, axonemal K10410 DNALI; dynein axonemal light intermediate chain 1
E 119659794 dynein light chain 1, axonemal-like K10411 DNAL1; dynein axonemal light chain 1
E 119659843 dynein light chain 1, axonemal K10411 DNAL1; dynein axonemal light chain 1
E 119660877 dynein light chain 4, axonemal K10412 DNAL4; dynein axonemal light chain 4
E 119648028 dynein heavy chain, cytoplasmic isoform X1 K10413 DYNC1H; dynein cytoplasmic 1 heavy chain
E 119652418 cytoplasmic dynein 2 heavy chain 1 K10414 DYNC2H; dynein cytoplasmic 2 heavy chain
E 119658486 cytoplasmic dynein 1 intermediate chain isoform X1 K10415 DYNC1I; dynein cytoplasmic 1 intermediate chain
E 119657677 cytoplasmic dynein 1 light intermediate chain 2 K10416 DYNC1LI; dynein cytoplasmic 1 light intermediate chain
E 119651561 cytoplasmic dynein 2 light intermediate chain 1 K10417 DYNC2LI; dynein cytoplasmic 2 light intermediate chain
E 119656119 dynein light chain 1, cytoplasmic isoform X1 K10418 DYNLL; dynein light chain LC8-type
E 119655375 dynein light chain roadblock-type 2-like K10419 DYNLRB; dynein light chain roadblock-type
E 119655542 dynein light chain roadblock-type 1-like K10419 DYNLRB; dynein light chain roadblock-type
E 119655793 dynein light chain roadblock-type 2-like K10419 DYNLRB; dynein light chain roadblock-type
E 119660297 dynein light chain Tctex-type K10420 DYNLT1_3; dynein light chain Tctex-type 1/3
E Dynein-related proteins
F 119651720 uncharacterized protein LOC119651720 K19750 DNAAF1; dynein axonemal assembly factor 1
F 119652818 protein kintoun K19751 DNAAF2; dynein axonemal assembly factor 2
F 119661295 dynein assembly factor 3, axonemal homolog K19752 DNAAF3; dynein axonemal assembly factor 3
F 119651915 dynein assembly factor 6, axonemal K24253 DNAAF6; dynein axonemal assembly factor 6
F 119650131 zinc finger MYND domain-containing protein 10 homolog K24030 ZMYND10; zinc finger MYND domain-containing protein 10
F 119650323 WD repeat-containing protein 92 K24761 WDR92; dynein axonemal assembly factor 10
F 119655145 protein tilB K19753 LRRC6; dynein axonemal assembly factor 11
F 119649532 uncharacterized protein LOC119649532 K25425 LRRC56; leucine-rich repeat-containing protein 56
F 119658550 PIH1 domain-containing protein 1 isoform X1 K25426 PIH1D1; PIH1 domain-containing protein 1
F 119651760 dynein assembly factor with WDR repeat domains 1 K19760 DAW1; dynein assembly factor with WDR repeat domains 1
D Dynactins
E 119659092 dynactin subunit 1 isoform X1 K04648 DCTN1; dynactin 1
E 119655712 dynactin subunit 2 K10424 DCTN2; dynactin 2
E 119658710 dynactin subunit 3 K10425 DCTN3; dynactin 3
E 119658018 dynactin subunit 4 K10426 DCTN4; dynactin 4
E 119650831 dynactin subunit 5 K10427 DCTN5; dynactin 5
E 119659471 dynactin subunit 6 K10428 DCTN6; dynactin 6
D Gamma-tubulin complex components
E 119655555 gamma-tubulin complex component 2 homolog isoform X1 K16569 TUBGCP2; gamma-tubulin complex component 2
E 119657322 gamma-tubulin complex component 3 isoform X1 K16570 TUBGCP3; gamma-tubulin complex component 3
D XMAP215
E 119658580 protein mini spindles isoform X1 K16803 CKAP5; cytoskeleton-associated protein 5
D Cytoplasmic linker proteins (CLIPs)
E CLIP-associating proteins
F 119648435 CLIP-associating protein isoform X1 K16578 CLASP1_2; CLIP-associating protein 1/2
D Fused toes protein (FTS)
E 119654211 protein crossbronx homolog K26419 AKTIP; AKT-interacting protein
D Hook proteins
E 119653757 protein hook isoform X1 K16536 HOOK3; protein HOOK3
D FTS and Hook-interacting proteins (FHIP)
E 119647637 UPF0518 protein GJ17503 isoform X1 K26420 FHIP1; FHF complex subunit HOOK interacting protein 1
E 119660357 protein FAM160B1-like K26421 FHIP2; FHF complex subunit HOOK interacting protein 2
D EB / APC
E 119652833 microtubule-associated protein RP/EB family member 1 isoform X1 K10436 MAPRE; microtubule-associated protein, RP/EB family
E 119652293 uncharacterized protein LOC119652293 K02085 APC; adenomatosis polyposis coli protein
D Microtubule-associated proteins (MAPs)
E 119659275 microtubule-associated proteins 1A/1B light chain 3B-like K10435 MAP1LC; microtubule-associated protein 1 light chain
E 119660412 EF-hand domain-containing protein 1-like K23029 EFHC1; EF-hand domain-containing protein 1
D Tubulin modification proteins
E Tubulin polyglutamylases
F 119648844 probable tubulin polyglutamylase TTLL1 K16599 TTLL1; tubulin polyglutamylase TTLL1 [EC:6.3.2.61]
F 119647082 tubulin polyglutamylase TTLL4-like isoform X1 K16601 TTLL4; tubulin polyglutamylase TTLL4 [EC:6.3.2.62]
F 119647249 tubulin polyglutamylase TTLL4-like isoform X1 K16601 TTLL4; tubulin polyglutamylase TTLL4 [EC:6.3.2.62]
F 119658843 tubulin polyglutamylase TTLL4-like isoform X1 K16601 TTLL4; tubulin polyglutamylase TTLL4 [EC:6.3.2.62]
F 119653009 tubulin polyglutamylase TTLL5 isoform X1 K16602 TTLL5; tubulin polyglutamylase TTLL5 [EC:6.3.2.61]
F 119660303 tubulin polyglutamylase ttll6-like isoform X1 K16582 TTLL6_13; tubulin polyglutamylase TTLL6/13 [EC:6.3.2.61]
F 119651700 probable tubulin polyglutamylase ttll-15 isoform X1 K16610 TTLL15; tubulin polyglutamylase TTLL15 [EC:6.3.2.-]
E Tubulin polyglutamylase complex components
F 119648109 tubulin polyglutamylase complex subunit 2 K16605 TPGS2; tubulin polyglutamylase complex subunit 2
F 119648844 probable tubulin polyglutamylase TTLL1 K16599 TTLL1; tubulin polyglutamylase TTLL1 [EC:6.3.2.61]
F 119650141 uncharacterized protein LOC119650141 K16606 LRRC49; leucine-rich repeat-containing protein 49
E Other tubulin modification proteins
F 119647314 tubulin glycylase 3A-like K16608 TTLL3_8; tubulin monoglycylase TTLL3/8 [EC:6.3.2.-]
F 119651838 tubulin glycylase 3A-like K16608 TTLL3_8; tubulin monoglycylase TTLL3/8 [EC:6.3.2.-]
F 119652619 tubulin--tyrosine ligase-like protein 12 K16609 TTLL12; tubulin--tyrosine ligase-like protein 12
D Others
E 119648877 tektin-1 K18628 TEKT1; tektin-1
E 119648971 tektin-B1 K18629 TEKT2; tektin-2
E 119657548 tektin-3-like isoform X1 K18630 TEKT3; tektin-3
E 119657564 tektin-3-like K18630 TEKT3; tektin-3
E 119652212 tektin-4 isoform X1 K18631 TEKT4; tektin-4
E 119655776 serine/threonine-protein kinase MARK2 isoform X1 K08798 MARK; MAP/microtubule affinity-regulating kinase [EC:2.7.11.1]
E 119646720 radial spoke head 1 homolog K19755 RSPH1; radial spoke head protein 1
E 119651600 radial spoke head protein 4 homolog A K19756 RSPH4_6; radial spoke head protein 4/6
E 119661559 radial spoke head protein 9 homolog K19757 RSPH9; radial spoke head protein 9
E 119650629 protein MEMO1 K06990 MEMO1; MEMO1 family protein
E 119658902 tubulin-specific chaperone A K17292 TBCA; tubulin-specific chaperone A
E 119656851 tubulin-folding cofactor B K17262 TBCB; tubulin-specific chaperone B
E 119660511 tubulin-specific chaperone C K21766 TBCC; tubulin-specific chaperone C
E 119656699 tubulin-specific chaperone D K21767 TBCD; tubulin-specific chaperone D
E 119655627 tubulin-specific chaperone E K21768 TBCE; tubulin-specific chaperone E
E 119653528 tubulin-specific chaperone cofactor E-like protein isoform X1 K22449 TBCEL; tubulin-specific chaperone cofactor E-like protein
E 119660148 N-acetyltransferase 9-like protein K25762 NAT9; tubulin N-terminal N-acetyltransferase [EC:2.3.1.308]
E 119650399 protein TANC2 K26456 TANC; protein TANC
B Septins
C Septins
D Group 1
E 119653816 septin-2 isoform X1 K16939 SEPT6_8_11; septin 6/8/11
D Group 2
E 119654970 septin-1 K16942 SEPT2; septin 2
E 119657510 septin-2 isoform X1 K16943 SEPT4; septin 4
E 119646814 septin-7 isoform X1 K16944 SEPT7; septin 7
D Group 3
D Group 4
C Septin associated proteins
D 119659285 E3 SUMO-protein ligase PIAS2 isoform X1 K04706 PIAS1; E3 SUMO-protein ligase PIAS1 [EC:2.3.2.-]
D 119657508 small ubiquitin-related modifier 3 isoform X1 K12160 SUMO; small ubiquitin-related modifier
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AProkaryotic cytoskeleton proteins
B Actin homologs
C Actins
C Actin-binding proteins
B Intermediate filaments homologs
B Microtubules homologs
B MinD / ParA class of bacterial cytoskeletal proteins
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: April 24, 2024