+D Transcription factors KO
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Transcription Factors - Hydra vulgaris (swiftwater hydra)
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AEukaryotic type
B Basic leucine zipper (bZIP)
C AP-1(-like) components, Jun
D 100198653 LOC100198653; X-box-binding protein 1 K09027 XBP1; X box-binding protein 1
D 100204820 jun; jun protein K04448 JUN; transcription factor AP-1
D 105851038 LOC105851038; uncharacterized protein LOC105851038 K04448 JUN; transcription factor AP-1
C AP-1(-like) components, Fos
D 101238916 LOC101238916; cyclic AMP-dependent transcription factor ATF-3 K09032 ATF3; activating transcription factor 3
C AP-1(-like) components, Maf
D 100199133 LOC100199133; uncharacterized protein LOC100199133 K09037 MAFF_G_K; transcription factor MAFF/G/K
C AP-1(-like) components, NF-E2
D 100209530 LOC100209530; uncharacterized protein LOC100209530 K09040 NFE2L1_3; nuclear factor erythroid 2-related factor 1/3
C AP-1(-like) components, Fungal regulators
C AP-1(-like) components, CRE-BP/ATF
D 100213904 LOC100213904; cyclic AMP-dependent transcription factor ATF-7 isoform X1 K04450 ATF2; cyclic AMP-dependent transcription factor ATF-2
D 101238916 LOC101238916; cyclic AMP-dependent transcription factor ATF-3 K09032 ATF3; activating transcription factor 3
D 100197237 LOC100197237; uncharacterized protein LOC100197237 K04374 ATF4; cyclic AMP-dependent transcription factor ATF-4
C CREB
D 100200223 LOC100200223; cyclic AMP-responsive element-binding protein K05870 CREB1; cyclic AMP-responsive element-binding protein 1
D 100207904 LOC100207904; uncharacterized protein LOC100207904 isoform X2 K09048 CREB3; cyclic AMP-responsive element-binding protein 3
D 100213735 LOC100213735; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 K09048 CREB3; cyclic AMP-responsive element-binding protein 3
C C/EBP-like factors
C bZIP/PAR
D 100204993 LOC100204993; thyrotroph embryonic factor K09057 HLF; hepatic leukemia factor
C Plant bZIP factors
C ZIP only
B Basic helix-loop-helix (bHLH)
C Ubiquitous (class A) factors
D 100202254 LOC100202254; transcription factor 12 isoform X2 K15603 TCF4_12; transcription factor 4/12
C Myogenic transcription factors
C Achaete-Scute
D 100215172 LOC100215172; achaete-scute homolog 1a-like K09067 ASCL; achaete-scute complex protein
D 101240255 LOC101240255; N-myc protein K09067 ASCL; achaete-scute complex protein
C Tal/Twist/Atonal/Hen, Lymphoid factors
C Tal/Twist/Atonal/Hen, Mesodermal Twist-like factors
D 105849691 LOC105849691; transcription factor 15 isoform X1 K09070 TCF15; transcription factor 15
D 124814117 LOC124814117; pancreas transcription factor 1 subunit alpha K09073 PTF1A; pancreas-specific transcription factor 1a
C Tal/Twist/Atonal/Hen, HEN
C Tal/Twist/Atonal/Hen, Mesp
C Tal/Twist/Atonal/Hen, Atonal
D 101241277 LOC101241277; uncharacterized protein LOC101241277 K09084 ATOH8; atonal protein 8
C Tal/Twist/Atonal/Hen, Pancreatic factors
C Hairy, Hairy/E(SPL)
C Hairy, Fungal regulators
C Factors with PAS domain
D 100204654 LOC100204654; hypoxia-inducible factor 1-alpha isoform X1 K08268 HIF1A; hypoxia-inducible factor 1 alpha
D 100211035 LOC100211035; aryl hydrocarbon receptor nuclear translocator 2 isoform X1 K09097 ARNT; aryl hydrocarbon receptor nuclear translocator
C Yabby
C INO
C HLH domain only
D 100206817 LOC100206817; transcription factor unc-3 isoform X1 K09103 EBF; early B-cell factor
B Basic helix-loop-helix/leucine zipper (bHLH-ZIP)
C Ubiquitous bHLH-ZIP factors
D 100199984 LOC100199984; microphthalmia-associated transcription factor isoform X1 K09455 MITF; microphthalmia-associated transcription factor
D 100204984 LOC100204984; upstream stimulatory factor 2 K09106 USF; upstream stimulatory factor
D 100200726 LOC100200726; uncharacterized protein LOC100200726 K07197 SREBP1; sterol regulatory element-binding transcription factor 1
C Cell cycle controlling factors, Myc
D 100199110 myc2; myc proto-oncogene protein 2 K04377 MYC; Myc proto-oncogene protein
D 105844435 LOC105844435; transcriptional regulator Myc-A K04377 MYC; Myc proto-oncogene protein
C Cell cycle controlling factors, Mad/Max
D 100215471 max; MYC associated factor X K04453 MAX; Max protein
D 100198848 LOC100198848; MLX-interacting protein isoform X1 K09113 MLX; MAX-like protein X
D 100214468 LOC100214468; max dimerization protein 1 K09114 MXD; MAX dimerization protein
C Other bHLH-ZIP factors
B Other basic domains
C NF-1
D 100200021 LOC100200021; uncharacterized protein LOC100200021 isoform X1 K09170 NFIC; nuclear factor I/C
D 100211197 LOC100211197; nuclear factor 1 B-type K09170 NFIC; nuclear factor I/C
C RF-X
D 100203968 LOC100203968; DNA-binding protein RFX2 isoform X1 K09173 RFX1_2_3; regulatory factor X 1/2/3
D 100205362 LOC100205362; transcription factor RFX4 isoform X1 K09174 RFX4; regulatory factor X 4
D 100203591 LOC100203591; uncharacterized protein LOC100203591 isoform X1 K09175 RFX7; DNA-binding protein RFX7
C AP-2 (bHSH)
D 100207967 LOC100207967; uncharacterized protein LOC100207967 isoform X1 K09176 TFAP2A_B; transcription factor AP-2 alpha/beta
B Zinc finger
C Cys4 thyroid hormone receptor-like
C Cys4 hepatocyte nuclear factor 4-like
D 101235557 LOC101235557; retinoic acid receptor RXR-alpha-B isoform X1 K08524 RXRA; retinoid X receptor alpha
D 100202117 LOC100202117; nuclear receptor subfamily 2 group E member 1 isoform X1 K08545 NR2E1; nuclear receptor subfamily 2 group E member 1
D 100204761 LOC100204761; nuclear receptor subfamily 2 group E member 1 isoform X1 K08546 NR2E3; nuclear receptor subfamily 2 group E member 3
D 100212284 LOC100212284; COUP transcription factor 2 K08547 NR2F1; COUP transcription factor 1
C Cys4 estrogen receptor-like
C Cys4 nerve growth factor IB-like
C Cys4 Fushi tarazu-F1-like
C Cys4 germ cell nuclear factor
C Cys4 Knirps/DAX1-like
C Cys4 GATA-factors
D 100208265 LOC100208265; trans-acting T-cell-specific transcription factor GATA-3 K17895 GATA3; GATA-binding protein 3
D 100207687 LOC100207687; GATA zinc finger domain-containing protein 1 K23407 GATAD1; GATA zinc finger domain-containing protein 1
D 100210830 LOC100210830; transcriptional repressor p66-beta isoform X1 K23194 GATAD2; transcriptional repressor p66
D 100211299 LOC100211299; egg-laying defective protein 27 isoform X1 K05628 RERE; arginine-glutamic acid dipeptide repeats protein
D 100199966 LOC100199966; metastasis-associated protein MTA3 K11660 MTA; metastasis-associated protein MTA
D 100209870 LOC100209870; DNA (cytosine-5)-methyltransferase 3A isoform X1 K17398 DNMT3A; DNA (cytosine-5)-methyltransferase 3A [EC:2.1.1.37]
D 100208125 LOC100208125; transcriptional regulator ATRX isoform X1 K10779 ATRX; transcriptional regulator ATRX
C Cys2His2 SP/KLF family and related proteins
D 100197623 LOC100197623; zinc finger protein 397 K09194 SP4; transcription factor Sp4
D 101237470 LOC101237470; transcription factor Sp5 K09195 SP5; transcription factor Sp5
D 101241519 LOC101241519; Krueppel-like factor 7 K09206 KLF5; krueppel-like factor 5
D 100207630 LOC100207630; Krueppel-like factor 6 K09207 KLF6_7; krueppel-like factor 6/7
D 100207116 LOC100207116; zinc finger protein 679 K09208 KLF9S; krueppel-like factor 9/13/14/16
D 100203494 LOC100203494; Kruppel-like factor 1 isoform X1 K09209 KLF10_11; krueppel-like factor 10/11
D 100214436 LOC100214436; early growth response protein 1-B K09203 EGR1; early growth response protein 1
C Cys2His2 GLI-like
D 101234776 LOC101234776; transcriptional activator cubitus interruptus K09233 GLIS2; zinc finger protein GLIS2
D 100202986 LOC100202986; uncharacterized protein LOC100202986 isoform X1 K18487 ZIC3; zinc finger protein ZIC 3
D 100210883 LOC100210883; zinc finger protein ZIC 4 K09227 ZICN; zinc finger protein ZIC, invertebrate
D 100203252 LOC100203252; uncharacterized protein LOC100203252 K16799 CI; transcriptional activator cubitus interruptus
C Cys2His2 Snail
D 100198876 LOC100198876; protein snail homolog Sna K05706 SNAI2; snail 2
C Cys2His2 BTB-ZF factors
C Cys2His2 BED
D 101237122 LOC101237122; zinc finger BED domain-containing protein 4-like isoform X1 K24640 ZBED4; zinc finger BED domain-containing protein 4
D 101237685 LOC101237685; zinc finger BED domain-containing protein 4 K24640 ZBED4; zinc finger BED domain-containing protein 4
D 105843543 LOC105843543; zinc finger BED domain-containing protein 4-like K24640 ZBED4; zinc finger BED domain-containing protein 4
D 105849009 LOC105849009; zinc finger BED domain-containing protein 4-like K24640 ZBED4; zinc finger BED domain-containing protein 4
C Cys2His2 PRDM
D 100204152 LOC100204152; putative histone-lysine N-methyltransferase PRDM6 isoform X1 K20795 PRDM6; [histone H4]-lysine20 N-methyltransferase PRDM6 [EC:2.1.1.361]
D 100208645 LOC100208645; histone-lysine N-methyltransferase PRDM9 isoform X1 K20795 PRDM6; [histone H4]-lysine20 N-methyltransferase PRDM6 [EC:2.1.1.361]
D 105845394 LOC105845394; histone-lysine N-methyltransferase PRDM9 isoform X1 K20796 PRDM7_9; [histone H3]-lysine4 N-trimethyltransferase PRDM7/9 [EC:2.1.1.354]
D 100213962 LOC100213962; zinc finger protein 256 K24645 PRDM13; PR domain zinc finger protein 13 [EC:2.1.1.-]
C Cys2His2 metabolic regulators in fungi
C Cys2His2 others
D 101236199 LOC101236199; transcriptional regulator ovo K09216 OVOL; ovo
D 101236759 LOC101236759; zinc finger protein Gfi-1b isoform X2 K09223 GFI1; growth factor independent 1
D 101237795 LOC101237795; zinc finger protein GFI1 homolog pag-3 K09223 GFI1; growth factor independent 1
D 101240198 LOC101240198; zinc finger protein 665 K09223 GFI1; growth factor independent 1
D 101240971 LOC101240971; zinc finger protein GFI1 homolog pag-3 isoform X1 K09223 GFI1; growth factor independent 1
D 105847942 LOC105847942; zinc finger protein Gfi-1b K09223 GFI1; growth factor independent 1
D 101234692 LOC101234692; histone-lysine N-methyltransferase PRDM9 isoform X1 K09191 GTF3A; general transcription factor IIIA
D 101235213 LOC101235213; transcription factor IIIA isoform X1 K09191 GTF3A; general transcription factor IIIA
D 100196971 LOC100196971; replication protein A 70 kDa DNA-binding subunit isoform X1 K07466 RFA1; replication factor A1
D 105845154 LOC105845154; zinc finger protein 3 homolog isoform X1 K09228 KRAB; KRAB domain-containing zinc finger protein
D 101237975 LOC101237975; histone H4 transcription factor isoform X1 K25794 HINFP; histone H4 transcription factor
D 101237680 LOC101237680; uncharacterized protein LOC101237680 isoform X1 K27895 ATMIN; ATM interactor
C Cys2HisCys zinc factors
D 100206753 LOC100206753; histone acetyltransferase KAT8 isoform X1 K11308 MYST1; histone acetyltransferase MYST1 [EC:2.3.1.48]
D 100206759 LOC100206759; histone acetyltransferase KAT7 isoform X1 K11307 MYST2; histone acetyltransferase MYST2 [EC:2.3.1.48]
D 100213192 LOC100213192; histone acetyltransferase KAT5 isoform X1 K11304 TIP60; histone acetyltransferase HTATIP [EC:2.3.1.48]
D 100210487 LOC100210487; lethal(3)malignant brain tumor-like protein 3 isoform X1 K24387 L3MBTL; lethal(3)malignant brain tumor-like protein
D 100211134 LOC100211134; cell growth-regulating nucleolar protein isoform X1 K15263 LYER; cell growth-regulating nucleolar protein
C Cys3His zinc factors
D 100214183 LOC100214183; roquin-1 isoform X1 K15690 RC3H; RING finger and CCCH-type zinc finger domain-containing protein
D 100204596 LOC100204596; uncharacterized protein LOC100204596 isoform X1 K10643 CNOT4; CCR4-NOT transcription complex subunit 4 [EC:2.3.2.27]
C Cys2CysHis zinc factors
D 101241734 LOC101241734; THAP domain-containing protein 1-like K23203 THAP1_3; THAP domain-containing protein 1/3
D 105850482 LOC105850482; THAP domain-containing protein 1 B-like K23203 THAP1_3; THAP domain-containing protein 1/3
C CXXC CpG-binding proteins
D 100210554 LOC100210554; uncharacterized protein LOC100210554 isoform X1 K14959 MLL4; [histone H3]-lysine4 N-trimethyltransferase MLL4 [EC:2.1.1.354]
D 100200520 LOC100200520; CXXC-type zinc finger protein 1 isoform X1 K14960 CXXC1; COMPASS component SPP1
D 100213294 LOC100213294; uncharacterized protein LOC100213294 isoform X1 K24309 TET2_3; methylcytosine dioxygenase TET2/3 [EC:1.14.11.80]
D 100202736 LOC100202736; DNA (cytosine-5)-methyltransferase PliMCI isoform X2 K00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]
D 100212991 LOC100212991; lysine-specific demethylase 2A isoform X1 K10276 FBXL10_11; F-box and leucine-rich repeat protein 10/11 [EC:1.14.11.27]
C Cys6 metabolic regulators in fungi
C Other zinc fingers
D 100203326 LOC100203326; transcriptional repressor NF-X1 isoform X1 K12236 NFX1; transcriptional repressor NF-X1
D 100213011 LOC100213011; CCHC-type zinc finger nucleic acid binding protein K09250 CNBP; cellular nucleic acid-binding protein
D 105846780 LOC105846780; zinc finger C4H2 domain-containing protein K24369 ZC4H2; zinc finger C4H2 domain-contaning protein
D 100202916 LOC100202916; probable E3 ubiquitin-protein ligase IRF2BPL K22383 IRF2BP; interferon regulatory factor 2-binding protein
B Helix-turn-helix
C Homeo domain ANTP: HOXL
D 100197809 LOC100197809; homeobox protein Hox-D10-like K09294 HOX_9; homeobox protein HoxB/C/D9
D 105850935 LOC105850935; homeobox protein mab-5 isoform X1 K09307 HOX_7; homeobox protein HoxA/B7
D 100215022 LOC100215022; homeobox protein Hox-C6a-like K09310 GSH; homeobox protein GSH
D 100213602 LOC100213602; homeobox protein Hox-C6 K07594 IPF1; insulin promoter factor 1
D 100214554 LOC100214554; homeobox protein pnx K09322 MEOX; homeobox protein MOX
C Homeo domain ANTP: NKL
D 100202331 LOC100202331; NK1 transcription factor-related protein 1 K09309 NKX1; homeobox protein Nkx-1
D 105845539 LOC105845539; homeobox protein ceh-22 K09342 NKX2-1; homeobox protein Nkx-2.1
D 100214228 LOC100214228; homeobox protein Hox-C3a-like K09345 NKX2-5; homeobox protein Nkx-2.5
D 100200338 LOC100200338; homeobox protein DLL-1 isoform X1 K09314 DLX1_4_6; homeobox protein DLX1/4/6
D 105849831 LOC105849831; homeobox protein vab-15 K09341 MSX; homeobox protein MSX
D 101236390 LOC101236390; homeobox protein ceh-28 K08024 HHEX; homeobox protein HEX
C Homeo domain Paired-related
D 100200211 LOC100200211; aristaless-related homeobox protein K09452 ARX; homeobox protein aristaless-related
D 100202877 LOC100202877; homeobox protein aristaless isoform X1 K09452 ARX; homeobox protein aristaless-related
D 100200175 LOC100200175; paired box protein Pax-3-like K09324 GSC; homeobox protein goosecoid
D 105846072 LOC105846072; homeobox protein OTX1 B K09326 OTX1; homeobox protein OTX1
D 100211908 LOC100211908; homeobox protein OTX2-like K18490 OTX2; homeobox protein OTX2
D 100213249 LOC100213249; short stature homeobox protein K09331 SHOX; short stature homeobox protein
D 101237920 LOC101237920; short stature homeobox protein 2 K09331 SHOX; short stature homeobox protein
D 101235096 LOC101235096; visual system homeobox 2 K09336 VSX2; visual system homeobox protein 2
D 100211037 LOC100211037; pituitary homeobox 1 K09356 PITX1; paired-like homeodomain transcription factor 1
D 100210788 LOC100210788; homeobox protein orthopedia K24901 OTP; homeobox protein orthopedia
D 100192230 LOC100192230; uncharacterized protein MAL13P1.336 K15608 PAX2; paired box protein 2
D 100192231 LOC100192231; homeobox protein 10 K09383 PAX5; paired box protein 5
C Homeo domain LIM
D 101239718 LOC101239718; uncharacterized protein LOC101239718 isoform X1 K09371 LMX1; LIM homeobox transcription factor 1
D 100211099 LOC100211099; cysteine and glycine-rich protein 2 K09377 CSRP; cysteine and glycine-rich protein
D 100212389 LOC100212389; cysteine and glycine-rich protein 2 isoform X1 K09377 CSRP; cysteine and glycine-rich protein
C Homeo domain POU
D 100210436 LOC100210436; POU domain, class 4, transcription factor 2 isoform X1 K09366 POU4F; POU domain transcription factor, class 4
C Homeo domain SINE
D 100192244 LOC100192244; homeobox protein SIX6 isoform X1 K19473 SIX3_6; homeobox protein SIX3/6
D 100192245 LOC100192245; homeobox protein SIX1 K15615 SIX4; homeobox protein SIX4
C Homeo domain ZF
C Homeo domain CUT
D 100197434 LOC100197434; protein CASP-like K09313 CUTL; homeobox protein cut-like
C Homeo domain PROS
C Homeo domain TALE
D 100203767 LOC100203767; pre-B-cell leukemia transcription factor 1 isoform X1 K09355 PBX1; pre-B-cell leukemia transcription factor 1
D 100215603 LOC100215603; homeobox protein Meis3 isoform X1 K16670 MEIS2; homeobox protein Meis2
D 100211771 LOC100211771; iroquois-class homeodomain protein IRX-2 K24889 IRX; iroquois-class homeodomain protein IRX
C Homeo domain other
C Fork head/winged helix developmental regulators
D 100213948 LOC100213948; hepatocyte nuclear factor 3-beta-like K08035 FOXA2; forkhead box protein A2, hepatocyte nuclear factor 3-beta
D 100202271 LOC100202271; forkhead box protein C1-B K09396 FOXC; forkhead box protein C
D 100199523 LOC100199523; forkhead box protein N4 isoform X1 K09407 FOXN; forkhead box protein N
D 101234582 LOC101234582; forkhead box protein N2 K09407 FOXN; forkhead box protein N
C Fork head/winged helix tissue-specific regulators
D 100208319 LOC100208319; uncharacterized protein LOC100208319 K09402 FOXJ1; forkhead box protein J1
C Fork head/winged helix cell cycle-controlling factors, E2F
D 100201375 LOC100201375; transcription factor E2F2 isoform X1 K09389 E2F2; transcription factor E2F2
D 100209310 LOC100209310; transcription factor E2F5 K04682 E2F4_5; transcription factor E2F4/5
D 100203927 LOC100203927; uncharacterized protein LOC100203927 isoform X1 K09391 E2F7_8; transcription factor E2F7/8
C Fork head/winged helix cell cycle-controlling factors, DP
D 100206033 LOC100206033; transcription factor Dp-1 isoform X1 K04683 TFDP1; transcription factor Dp-1
C Fork head/winged helix other regulators
D 100203541 LOC100203541; forkhead box protein B1 K09395 FOXB; forkhead box protein B
D 100208304 LOC100208304; forkhead box protein J3 isoform X1 K09403 FOXJ2_3; forkhead box protein J2/3
D 100202276 LOC100202276; forkhead box protein K2 K09404 FOXK; forkhead box protein K
D 100202184 LOC100202184; forkhead box protein O1 isoform X1 K09408 FOXO3; forkhead box protein O3
C Stork head/winged helix factors
D 101239572 LOC101239572; uncharacterized protein LOC101239572 K28389 STOX; storkhead-box protein
C Heat shock factors
D 100209282 LOC100209282; heat shock factor protein isoform X1 K09414 HSF1; heat shock transcription factor 1
C Tryptophan clusters Myb, Myb-factors
C Tryptophan clusters Myb, Myb-like factors
D 105845985 LOC105845985; uncharacterized protein LOC105845985 isoform X1 K09453 SNAPC4; snRNA-activating protein complex subunit 4
D 100203899 LOC100203899; cyclin-D-binding Myb-like transcription factor 1 isoform X1 K21625 DMTF1; cyclin-D-binding Myb-like transcription factor 1
D 101238957 LOC101238957; mesoderm induction early response protein 1 isoform X1 K28169 MIER1; mesoderm induction early response protein 1
C Tryptophan clusters Ets-type
D 100208132 LOC100208132; ETS translocation variant 1 isoform X1 K09431 ETV1; ets translocation variant 1
D 100199297 LOC100199297; Friend leukemia integration 1 transcription factor K09435 ERG; transcriptional regulator ERG
D 100199698 LOC100199698; transcriptional regulator ERG-like K09435 ERG; transcriptional regulator ERG
D 100201698 LOC100201698; DNA-binding protein Ets97D isoform X1 K09441 GABPA; GA-binding protein transcription factor, alpha
C Tryptophan clusters interferon-regulating factors
D 100215166 LOC100215166; uncharacterized protein LOC100215166 isoform X1 K10153 IRF2; interferon regulatory factor 2
D 100201914 LOC100201914; uncharacterized protein LOC100201914 isoform X1 K09445 IRF4; interferon regulatory factor 4
C TEA domain
D 100210210 LOC100210210; transcriptional enhancer factor TEF-1 isoform X1 K09448 TEAD; transcriptional enhancer factor
D 105843218 LOC105843218; uncharacterized protein LOC105843218 K09448 TEAD; transcriptional enhancer factor
D 105844273 LOC105844273; uncharacterized protein LOC105844273 K09448 TEAD; transcriptional enhancer factor
C ARID
D 100209641 LOC100209641; AT-rich interactive domain-containing protein 1A K11653 ARID1; AT-rich interactive domain-containing protein 1
D 100198293 LOC100198293; uncharacterized protein LOC100198293 isoform X1 K11765 ARID2; AT-rich interactive domain-containing protein 2
D 101237132 LOC101237132; AT-rich interactive domain-containing protein 4B isoform X1 K19194 ARID4A; AT-rich interactive domain-containing protein 4A
B beta-Scaffold factors with minor groove contacts
C RHR (Rel homology region) Rel/Ankyrin
C RHR (Rel homology region) Ankyrin only
D 105843570 LOC105843570; WD repeat domain phosphoinositide-interacting protein 4 isoform X1 K09256 NFKBIL1; NF-kappa-B inhibitor-like protein 1
D 100206904 LOC100206904; tonsoku-like protein isoform X1 K09257 NFKBIL2; NF-kappa-B inhibitor-like protein 2
D 101234786 LOC101234786; putative ankyrin repeat protein RF_0381 isoform X1 K09454 GABPB; GA-binding protein transcription factor, beta
C RHR (Rel homology region) NF-AT
D 101236754 LOC101236754; uncharacterized protein LOC101236754 isoform X1 K17335 NFAT5; nuclear factor of activated T-cells 5
C STAT
D 100206878 LOC100206878; signal transducer and activator of transcription 5B isoform X1 K11224 STAT5B; signal transducer and activator of transcription 5B
C p53
D 100207213 LOC100207213; cellular tumor antigen p53 isoform X1 K04451 TP53; tumor protein p53
C MADS-box regulators of differentiation, MEF-2
D 100204453 LOC100204453; myocyte-specific enhancer factor 2C isoform X1 K09260 MEF2A; MADS-box transcription enhancer factor 2A
C MADS-box regulators of differentiation, Homeotic genes
C MADS-box regulators of differentiation, Yeast regulators
C MADS-box responders to external signals
D 100201178 LOC100201178; serum response factor homolog K04378 SRF; serum response factor
C SAND domain-containing proteins
D 101237728 LOC101237728; deformed epidermal autoregulatory factor 1 homolog isoform X1 K23041 DEAF1; deformed epidermal autoregulatory factor 1
C TATA-binding proteins
D 100209233 LOC100209233; uncharacterized protein LOC100209233 isoform X1 K03120 TBP; transcription initiation factor TFIID TATA-box-binding protein
C HMG SOX
D 100214575 LOC100214575; transcription factor SOX-14 K09267 SOX1S; transcription factor SOX1/3/14/21 (SOX group B)
D 100203898 LOC100203898; transcription factor Sox-21-B K16796 SOX2; transcription factor SOX2 (SOX group B)
D 100205840 LOC100205840; transcription factor Sox-21 K16796 SOX2; transcription factor SOX2 (SOX group B)
D 100209449 LOC100209449; uncharacterized protein LOC100209449 K16796 SOX2; transcription factor SOX2 (SOX group B)
D 100211256 LOC100211256; transcription factor Sox-21-B K16796 SOX2; transcription factor SOX2 (SOX group B)
D 100201982 LOC100201982; transcription factor SOX-18 K09270 SOX7S; transcription factor SOX7/8/10/18 (SOX group E/F)
D 100200724 LOC100200724; protein capicua homolog isoform X1 K20225 CIC; capicua transcriptional repressor
D 100201739 LOC100201739; uncharacterized protein LOC100201739 isoform X1 K21644 HBP1; HMG box transcription factor 1
C HMG TCF-1
D 100199257 LOC100199257; transcription factor 7-like 2 K04491 TCF7L2; transcription factor 7-like 2
C HMG TOX
D 100198143 LOC100198143; uncharacterized protein LOC100198143 isoform X1 K28489 TOX; thymocyte selection-associated high mobility group box protein
D 100202185 LOC100202185; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 isoform X1 K11651 SMARCE1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1
D 100210175 LOC100210175; high mobility group protein 20A K24660 HMG20A; high mobility group protein 20A
C HMG2-related
D 100209709 LOC100209709; FACT complex subunit SSRP1 isoform X1 K09272 SSRP1; FACT complex subunit SSRP1/POB3
C UBF
C Other HMG box factors
C Heteromeric CCAAT factors
D 100214343 LOC100214343; nuclear transcription factor Y subunit beta isoform X1 K08065 NFYB; nuclear transcription Y subunit beta
D 100213726 LOC100213726; nuclear transcription factor Y subunit gamma isoform X1 K08066 NFYC; nuclear transcription factor Y, gamma
C Grainyhead
D 100204082 LOC100204082; grainyhead-like protein 1 homolog isoform X1 K09275 TFCP2; transcription factor CP2 and related proteins
D 101237804 LOC101237804; transcription factor CP2 isoform X1 K09275 TFCP2; transcription factor CP2 and related proteins
C Cold-shock domain factors, DbpA-like
C Cold-shock domain factors, YB-1/DbpB-like
D 100211522 LOC100211522; Y-box factor homolog K09276 YBX1; Y-box-binding protein 1
C Cold-shock domain factors, FRG Y2-like
C Runt
D 100192283 LOC100192283; Runx K09278 RUNX2; runt-related transcription factor 2
C MYRF
B Other transcription factors
C HMGI(Y)
C NUPR
C Pocket domain Rb
D 101240404 LOC101240404; retinoblastoma-like protein 1 isoform X1 K04681 RBL1; retinoblastoma-like protein 1
C Pocket domain CBP
D 100203474 LOC100203474; histone acetyltransferase p300 isoform X1 K04498 EP300; E1A/CREB-binding protein [EC:2.3.1.48]
C T-box
D 100204831 LOC100204831; brachyury protein-like K10172 BRA; brachyury protein
D 100209110 LOC100209110; brachyury protein homolog 1-like K10172 BRA; brachyury protein
D 100202104 LOC100202104; T-box transcription factor TBX1 isoform X1 K10175 TBX1; T-box protein 1
D 100209288 LOC100209288; T-box protein 2 K10176 TBX2; T-box protein 2
C DMRT
D 100204588 LOC100204588; doublesex- and mab-3-related transcription factor 1 K19488 DMRT1; doublesex- and mab-3-related transcription factor 1
D 100204042 LOC100204042; doublesex- and mab-3-related transcription factor A2 isoform X1 K19491 DMRT4_5; doublesex- and mab-3-related transcription factor 4/5
D 100211851 LOC100211851; doublesex- and mab-3-related transcription factor A1 K19491 DMRT4_5; doublesex- and mab-3-related transcription factor 4/5
C LRRFIP
D 100207951 LOC100207951; uncharacterized protein PF3D7_1120600 isoform X1 K26434 LRRFIP; leucine-rich repeat flightless-interacting protein
C TCP
C AP2/ERF
C WRKY
C LOB
C GRAS
C NAC
C Copper-fist proteins fungal regulators
C Others
D 105850732 LOC105850732; uncharacterized protein LOC105850732 K21595 CARF; calcium-responsive transcription factor
D 101235217 LOC101235217; transmembrane protein 18 isoform X1 K22145 TMEM18; transmembrane protein 18
D 100204049 LOC100204049; coiled-coil-helix-coiled-coil-helix domain-containing protein 2 isoform X1 K22758 CHCHD2; coiled-coil-helix-coiled-coil-helix domain-containing protein 2
D 100203810 LOC100203810; recombining binding protein suppressor of hairless isoform X1 K06053 RBPSUH; recombining binding protein suppressor of hairless
D 101236852 LOC101236852; GON-4-like protein isoform X2 K23804 GON4L; GON-4-like protein
D 100203528 LOC100203528; transcriptional activator protein Pur-alpha isoform X1 K21772 PURA; transcriptional activator protein Pur-alpha
D 100214317 LOC100214317; myelin expression factor 2 K24992 MYEF2; myelin expression factor 2
D 100202377 LOC100202377; cell division cycle-associated protein 7 K23408 CDCA7; cell division cycle-associated protein 7
D 100213376 LOC100213376; NF-kappa-B-repressing factor K26458 NKRF; NF-kappa-B-repressing factor
D 100202211 ecd; ecdysoneless homolog K28083 ECD; protein ecdysoneless
#
AProkaryotic type
B Helix-turn-helix
C AraC family
C LysR family
C DeoR family
C LacI family
C GntR family
C TetR/AcrR family
C Lrp/AsnC family
C LuxR family
C MarR family
C MerR family
C Fur family
C IclR family
C CRP/FNR family
C Rrf2 family
C ArsR family
C XRE family
C PadR family
C Other families
B Ribbon-helix-helix
C CopG family
C Other families
B Other transcription factors
C BglG family
C Others
!
#
#[ BRITE | KEGG2 | KEGG ]
#Last updated: July 7, 2026
#
Classification taken and modified from TRANSFAC 7.0