+F Repair protein KO
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DNA Repair and Recombination Proteins - Hydra vulgaris (swiftwater hydra)
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AEukaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D 100199101 methylated-DNA--protein-cysteine methyltransferase K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
D 100215008 DNA oxidative demethylase ALKBH2 K10859 ALKBH2; DNA oxidative demethylase [EC:1.14.11.33]
D 101239914 activating signal cointegrator 1 complex subunit 3-like K18663 ASCC3; activating signal cointegrator complex subunit 3 [EC:5.6.2.4]
C BER (base exicision repair)
D DNA glycosylases
E 100207347 uracil-DNA glycosylase isoform X1 K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E 100203258 G/T mismatch-specific thymine DNA glycosylase K20813 TDG; thymine-DNA glycosylase [EC:3.2.2.29]
E 100206585 G/T mismatch-specific thymine DNA glycosylase K20813 TDG; thymine-DNA glycosylase [EC:3.2.2.29]
E 100205662 adenine DNA glycosylase-like isoform X1 K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
E 100205338 uncharacterized protein LOC100205338 isoform X1 K10801 MBD4; methyl-CpG-binding domain protein 4 [EC:3.2.2.-]
E 100201758 N-glycosylase/DNA lyase K03660 OGG1; N-glycosylase/DNA lyase [EC:3.2.2.- 4.2.99.18]
E 100212522 endonuclease 8-like 1 isoform X1 K10567 NEIL1; endonuclease VIII-like 1 [EC:3.2.2.- 4.2.99.18]
E 100200675 endonuclease III-like protein 1 isoform X1 K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
E 100201725 DNA-(apurinic or apyrimidinic site) endonuclease K10771 APEX1; AP endonuclease 1 [EC:3.1.11.2]
E 100210591 DNA-(apurinic or apyrimidinic site) endonuclease 2 K10772 APEX2; AP endonuclease 2 [EC:3.1.11.2]
D Long Patch-BER factors
E DNA polymerase delta complex
F 100200641 DNA polymerase delta catalytic subunit K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
F 100214471 DNA polymerase delta subunit 2 K02328 POLD2; DNA polymerase delta subunit 2
E DNA polymerase epsilon complex
F 100207477 DNA polymerase epsilon catalytic subunit A K02324 POLE; DNA polymerase epsilon subunit 1 [EC:2.7.7.7]
F 100197376 DNA polymerase epsilon subunit 2 isoform X1 K02325 POLE2; DNA polymerase epsilon subunit 2 [EC:2.7.7.7]
F 100213235 DNA polymerase epsilon subunit 3 K02326 POLE3; DNA polymerase epsilon subunit 3 [EC:2.7.7.7]
E 100204143 proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
E 100200434 flap endonuclease 1-like K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
E 100206246 DNA ligase 1 isoform X1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
D Short Patch-BER factors
E 100208145 DNA repair protein XRCC1 isoform X1 K10803 XRCC1; DNA-repair protein XRCC1
E 101236307 DNA ligase 3 isoform X1 K10776 LIG3; DNA ligase 3 [EC:6.5.1.1]
D Other BER factors
E 100204246 tyrosyl-DNA phosphodiesterase 1 K10862 TDP1; tyrosyl-DNA phosphodiesterase 1 [EC:3.1.4.-]
E 100206030 aprataxin K10863 APTX; aprataxin [EC:3.6.1.70 3.6.1.71 3.6.1.72]
E 101235320 aprataxin and PNK-like factor isoform X1 K13295 APLF; aprataxin and PNK-like factor [EC:3.1.-.-]
E 105843083 bifunctional polynucleotide phosphatase/kinase-like K08073 PNKP; bifunctional polynucleotide phosphatase/kinase [EC:3.1.3.32 2.7.1.78]
E 101240572 poly [ADP-ribose] polymerase 1 K24070 PARP1; poly [ADP-ribose] polymerase 1 [EC:2.4.2.30]
E 100202139 protein mono-ADP-ribosyltransferase PARP3 K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
E 101241649 protein mono-ADP-ribosyltransferase PARP4 isoform X1 K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
E 100205425 poly [ADP-ribose] polymerase 2 K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E XPC-HR23B-CETN2 complex
F 100208477 DNA repair protein complementing XP-C cells homolog K10838 XPC; xeroderma pigmentosum group C-complementing protein
F 100201209 UV excision repair protein RAD23 homolog B K10839 RAD23; UV excision repair protein RAD23
E Cul4-DDB2 complex
F 100204043 RING-box protein 1 K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
F 100199190 cullin-4A K10609 CUL4; cullin 4
F 100203542 DNA damage-binding protein 1 K10610 DDB1; DNA damage-binding protein 1
E NER4 complex
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase II complex
F 100204515 DNA-directed RNA polymerase II subunit RPB1 K03006 RPB1; DNA-directed RNA polymerase II subunit RPB1 [EC:2.7.7.6]
F 100204431 DNA-directed RNA polymerase II subunit RPB1-like K03006 RPB1; DNA-directed RNA polymerase II subunit RPB1 [EC:2.7.7.6]
F 100208869 DNA-directed RNA polymerase II subunit RPB2 K03010 RPB2; DNA-directed RNA polymerase II subunit RPB2 [EC:2.7.7.6]
F 100200529 DNA-directed RNA polymerase II subunit RPB3 K03011 RPB3; DNA-directed RNA polymerase II subunit RPB3
F 100214917 DNA-directed RNA polymerase II subunit RPB4 K03012 RPB4; DNA-directed RNA polymerase II subunit RPB4
F 100208454 DNA-directed RNA polymerases I, II, and III subunit RPABC1-like K03013 RPABC1; DNA-directed RNA polymerases I, II, and III subunit RPABC1
F 101241478 DNA-directed RNA polymerases I, II, and III subunit RPABC2 K03014 RPABC2; DNA-directed RNA polymerases I, II, and III subunit RPABC2
F 100197989 DNA-directed RNA polymerase II subunit RPB7 K03015 RPB7; DNA-directed RNA polymerase II subunit RPB7
F 100210790 DNA-directed RNA polymerase II subunit RPB9 K03017 RPB9; DNA-directed RNA polymerase II subunit RPB9
F 100198493 DNA-directed RNA polymerase II subunit RPB11 K03008 RPB11; DNA-directed RNA polymerase II subunit RPB11
E Cul4-CSA complex
F 100204043 RING-box protein 1 K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
F 100199190 cullin-4A K10609 CUL4; cullin 4
F 100203542 DNA damage-binding protein 1 K10610 DDB1; DNA damage-binding protein 1
F 100205713 DNA excision repair protein ERCC-8 isoform X2 K10570 ERCC8; DNA excision repair protein ERCC-8
E Other TCR factor
F 100206578 DNA repair protein rhp26 K10841 ERCC6; DNA excision repair protein ERCC-6
F 105846731 UV-stimulated scaffold protein A K23720 UVSSA; UV-stimulated scaffold protein A
F 100213097 transcription elongation factor 1 homolog K25829 ELOF1; transcription elongation factor 1
D TFIIH complex
E 100208821 TFIIH basal transcription factor complex helicase XPB subunit-like K10843 ERCC3; DNA excision repair protein ERCC-3 [EC:5.6.2.4]
E 100200345 general transcription and DNA repair factor IIH helicase subunit XPD K10844 ERCC2; DNA excision repair protein ERCC-2 [EC:5.6.2.3]
E 100213291 general transcription factor IIH subunit 1 isoform X1 K03141 TFIIH1; transcription initiation factor TFIIH subunit 1
E 100200565 general transcription factor IIH subunit 2 K03142 TFIIH2; transcription initiation factor TFIIH subunit 2
E 100201597 max-like protein X isoform X3 K03143 TFIIH3; transcription initiation factor TFIIH subunit 3
E 100211920 general transcription factor IIH subunit 4 K03144 TFIIH4; transcription initiation factor TFIIH subunit 4
E 100197655 cyclin-dependent kinase 7 K02202 CDK7; cyclin-dependent kinase 7 [EC:2.7.11.22 2.7.11.23]
E 100213308 cyclin-H K06634 CCNH; cyclin H
E 100211005 CDK-activating kinase assembly factor MAT1 K10842 MNAT1; CDK-activating kinase assembly factor MAT1
D RPA (replication factor A)
E 100196971 replication protein A 70 kDa DNA-binding subunit K07466 RFA1; replication factor A1
E 100214070 replication protein A 32 kDa subunit K10739 RFA2; replication factor A2
E 100208760 replication protein A 14 kDa subunit K10740 RPA3; replication factor A3
D Other NER factors
E 100209409 DNA repair protein complementing XP-A cells homolog K10847 XPA; DNA-repair protein complementing XP-A cells
E 101236335 DNA excision repair protein ERCC-1 K10849 ERCC1; DNA excision repair protein ERCC-1
E 100198919 DNA excision repair protein ERCC-5 homolog isoform X1 K10846 ERCC5; DNA excision repair protein ERCC-5
E 100206246 DNA ligase 1 isoform X1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
E 100202294 MMS19 nucleotide excision repair protein homolog K15075 MET18; DNA repair/transcription protein MET18/MMS19
E 100202538 cullin-3 K03869 CUL3; cullin 3
E 100210839 elongin-C K03872 ELOC; elongin-C
E 100198637 elongin-B K03873 ELOB; elongin-B
E 100197929 elongin-A isoform X1 K15076 ELOA; elongin-A
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
E 100200908 DNA mismatch repair protein Msh2 isoform X1 K08735 MSH2; DNA mismatch repair protein MSH2
E 100201087 DNA mismatch repair protein Msh3 K08736 MSH3; DNA mismatch repair protein MSH3
E 100209507 DNA mismatch repair protein Msh6-like K08737 MSH6; DNA mismatch repair protein MSH6
D MutL homologs
E 100209498 PMS1 protein homolog 1 isoform X1 K10864 PMS1; DNA mismatch repair protein PMS1
E 100198136 DNA mismatch repair protein Mlh1-like isoform X1 K08734 MLH1; DNA mismatch repair protein MLH1
E 100206285 mismatch repair endonuclease PMS2 K10858 PMS2; DNA mismatch repair protein PMS2
D DNA polymerase delta complex
E 100200641 DNA polymerase delta catalytic subunit K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
E 100214471 DNA polymerase delta subunit 2 K02328 POLD2; DNA polymerase delta subunit 2
D RPA (replication factor A)
E 100196971 replication protein A 70 kDa DNA-binding subunit K07466 RFA1; replication factor A1
E 100214070 replication protein A 32 kDa subunit K10739 RFA2; replication factor A2
E 100208760 replication protein A 14 kDa subunit K10740 RPA3; replication factor A3
D RFC (replication factor C)
E 100190918 rfc1; replication factor C large subunit K10754 RFC1; replication factor C subunit 1
E 100205184 replication factor C subunit 4 K10755 RFC2_4; replication factor C subunit 2/4
E 100199898 replication factor C subunit 2 isoform X1 K10755 RFC2_4; replication factor C subunit 2/4
E 100206290 replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
E 100208083 replication factor C subunit 5-like K10756 RFC3_5; replication factor C subunit 3/5
E 101236243 probable replication factor C subunit 5 K10756 RFC3_5; replication factor C subunit 3/5
D Other MMR factors
E 100204143 proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
E 101238090 exonuclease 1 K10746 EXO1; exonuclease 1 [EC:3.1.-.-]
E 100206246 DNA ligase 1 isoform X1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
E 100204875 WD repeat-containing protein 76 K24755 WDR76; WD repeat-containing protein 76
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D MRN(MRX) complex
E 100215233 double-strand break repair protein MRE11-like K10865 MRE11; double-strand break repair protein MRE11
E 100197600 nibrin K10867 NBN; nibrin
D BRCA1-core complex
E 100213455 breast cancer type 1 susceptibility protein homolog isoform X1 K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 101234293 BRCA1-associated RING domain protein 1 isoform X1 K10683 BARD1; BRCA1-associated RING domain protein 1
D BRCA1-A complex
E 100213455 breast cancer type 1 susceptibility protein homolog isoform X1 K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 101236705 uncharacterized protein LOC101236705 K20776 BABAM; BRISC and BRCA1-A complex member 1
E 100213466 lys-63-specific deubiquitinase BRCC36 K11864 BRCC3; BRCA1/BRCA2-containing complex subunit 3 [EC:3.4.19.-]
D BRCA1-B complex
E 100213455 breast cancer type 1 susceptibility protein homolog isoform X1 K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 100213284 DNA topoisomerase 2-binding protein 1-A K10728 TOPBP1; topoisomerase (DNA) II binding protein 1
D BRCA1-C complex
E 100213455 breast cancer type 1 susceptibility protein homolog isoform X1 K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 100215233 double-strand break repair protein MRE11-like K10865 MRE11; double-strand break repair protein MRE11
E 100197600 nibrin K10867 NBN; nibrin
D BRCA complex
E 100213455 breast cancer type 1 susceptibility protein homolog isoform X1 K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 101237032 breast cancer type 2 susceptibility protein homolog isoform X1 K08775 BRCA2; breast cancer 2 susceptibility protein
E 100204009 DNA repair protein RAD51 homolog A K04482 RAD51; DNA repair protein RAD51
D RecA family proteins
E 100204009 DNA repair protein RAD51 homolog A K04482 RAD51; DNA repair protein RAD51
E 100213046 DNA repair protein RAD51 homolog 3 isoform X1 K10870 RAD51L2; RAD51-like protein 2
E 101236857 DNA repair protein RAD51 homolog 4 isoform X1 K10871 RAD51L3; RAD51-like protein 3
E 101235392 DNA repair protein XRCC2 K10879 XRCC2; DNA-repair protein XRCC2
E 100204276 DNA repair protein XRCC3 K10880 XRCC3; DNA-repair protein XRCC3
D Rad52 family proteins
D Rad54 family proteins
E 100197301 DNA repair and recombination protein RAD54-like K10875 RAD54L; DNA repair and recombination protein RAD54 and RAD54-like protein [EC:5.6.2.-]
E 100203008 helicase ARIP4 K10876 RAD54L2; RAD54-like protein 2 [EC:5.6.2.-]
E 100208757 DNA repair and recombination protein RAD54B K10877 RAD54B; DNA repair and recombination protein RAD54B [EC:5.6.2.-]
D RecQ family DNA helicases
E 100200344 ATP-dependent DNA helicase Q1 K10899 RECQL; ATP-dependent DNA helicase Q1 [EC:5.6.2.4]
E 100213322 Werner syndrome ATP-dependent helicase homolog K10900 WRN; werner syndrome ATP-dependent helicase [EC:5.6.2.4]
E 100205617 Bloom syndrome protein homolog K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 100201062 ATP-dependent DNA helicase Q4-like K10730 RECQL4; ATP-dependent DNA helicase Q4 [EC:5.6.2.4]
D Bloom's syndrome complex (BTR)
E 100205617 Bloom syndrome protein homolog K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 100213698 DNA topoisomerase 3-beta-1 isoform X1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 100202958 DNA topoisomerase 3-alpha isoform X1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 100215195 uncharacterized protein LOC100215195 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
D RPA (replication factor A)
E 100196971 replication protein A 70 kDa DNA-binding subunit K07466 RFA1; replication factor A1
E 100214070 replication protein A 32 kDa subunit K10739 RFA2; replication factor A2
E 100208760 replication protein A 14 kDa subunit K10740 RPA3; replication factor A3
D Protein phosphatase 4
E 100200590 serine/threonine-protein phosphatase 4 catalytic subunit K15423 PPP4C; serine/threonine-protein phosphatase 4 catalytic subunit [EC:3.1.3.16]
E 100202434 serine/threonine-protein phosphatase 4 regulatory subunit 1 K15424 PPP4R1; serine/threonine-protein phosphatase 4 regulatory subunit 1
E 100215274 serine/threonine-protein phosphatase 4 regulatory subunit 2 K15425 PPP4R2; serine/threonine-protein phosphatase 4 regulatory subunit 2
E 100212793 serine/threonine-protein phosphatase 4 regulatory subunit 3B K17491 SMEK; protein phosphatase 4 regulatory subunit 3
E 101235859 serine/threonine-protein phosphatase 4 regulatory subunit 4 isoform X1 K15426 PPP4R4; serine/threonine-protein phosphatase 4 regulatory subunit 4
D AP-5 complex
E 100200134 AP-5 complex subunit beta-1 K19022 AP5B1; AP-5 complex subunit beta-1
E 100202750 AP-5 complex subunit mu-1 isoform X1 K19023 AP5M1; AP-5 complex subunit mu-1
E 101236065 AP-5 complex subunit sigma-1 K19024 AP5S1; AP-5 complex subunit sigma-1
D SMC5-SMC6 complex
E 100203090 structural maintenance of chromosomes protein 5 isoform X1 K22803 SMC5; structural maintenance of chromosomes protein 5
E 100204530 structural maintenance of chromosomes protein 6 K22804 SMC6; structural maintenance of chromosomes protein 6
E 100212201 E3 SUMO-protein ligase NSE2 K22756 NSMCE2; E3 SUMO-protein ligase NSE2 [EC:2.3.2.-]
E 100197474 non-structural maintenance of chromosomes element 3 homolog K22823 NSMCE3; non-structural maintenance of chromosomes element 3
E 101238394 non-structural maintenance of chromosomes element 4 homolog A K22825 NSMCE4; non-structural maintenance of chromosomes element 4
E 100211252 SMC5-SMC6 complex localization factor protein 1-like isoform X1 K26126 SLF1; SMC5-SMC6 complex localization factor protein 1
D Other HR factors
E 100202321 crossover junction endonuclease EME1 isoform X2 K10882 EME1; crossover junction endonuclease EME1 [EC:3.1.22.-]
E 100200439 exonuclease 3'-5' domain-containing protein 2-like K20777 EXD2; exonuclease 3'-5' domain-containing protein 2 [EC:3.1.11.1]
E 100201232 crossover junction endonuclease MUS81 isoform X1 K08991 MUS81; crossover junction endonuclease MUS81 [EC:3.1.22.-]
E 100212313 26S proteasome complex subunit SEM1 K10881 SHFM1; 26 proteasome complex subunit DSS1
E 101236746 DNA repair protein SWI5 homolog K10991 SWI5; DNA repair protein Swi5/Sae3
E 105845897 swi5-dependent recombination DNA repair protein 1 homolog K10992 SFR1; Swi5-dependent recombination DNA repair protein 1
E 100215220 flap endonuclease GEN homolog 1 isoform X1 K15338 GEN1; holliday junction resolvase GEN1/YEN1 [EC:3.1.-.-]
E 101237023 spatacsin isoform X1 K19026 SPG11; spatacsin
E 100197921 zinc finger FYVE domain-containing protein 26 isoform X1 K19027 ZFYVE26; zinc finger FYVE domain-containing protein 26
E 100213193 DEK domain-containing chromatin-associated protein 4 K20778 RAD51AP1; RAD51-associated protein 1
E 100197355 mortality factor 4-like protein 1 K11339 MORF4L1; mortality factor 4-like protein 1
E 100200569 deoxynucleoside triphosphate triphosphohydrolase SAMHD1-like isoform X1 K22544 SAMHD1; deoxynucleoside triphosphate triphosphohydrolase SAMHD1 [EC:3.1.5.-]
E 100212287 fidgetin-like protein 1 K22766 FIGNL1; fidgetin-like protein 1 [EC:5.6.2.-]
E 101241672 uncharacterized protein LOC101241672 isoform X1 K22806 SPIDR; DNA repair-scaffolding protein
E 101238609 uncharacterized protein LOC101238609 isoform X1 K23112 BRAT1; BRCA1-associated ATM activator 1
E 100206134 leucine-rich repeat-containing protein 40 K23456 CFAP410; cilla- and flagella-associated protein
E 100213266 hepatoma-derived growth factor-related protein 2 isoform X1 K25065 HDGFL2; hepatoma-derived growth factor-related protein 2
E 100213748 zinc finger SWIM domain-containing protein 7 K25770 ZSWIM7; zinc finger SWIM domain-containing protein 7
E 105843689 uncharacterized protein LOC105843689 K25771 SWSAP1; ATPase SWSAP1
E 100201974 uncharacterized protein LOC100201974 isoform X1 K25790 EMSY; BRCA2-interacting transcriptional repressor EMSY
E 101236770 protein MMS22-like isoform X1 K26125 MMS22L; protein MMS22-like
E 100206904 tonsoku-like protein K09257 NFKBIL2; NF-kappa-B inhibitor-like protein 2
E 101239788 PCNA-interacting partner isoform X2 K27412 PARPBP; PCNA-interacting partner
C NHEJ (non-homologous end-joining)
D DNA-PK complex
E 100211211 X-ray repair cross-complementing protein 5 K10884 XRCC6; ATP-dependent DNA helicase 2 subunit 1
E 100208923 X-ray repair cross-complementing protein 5 K10885 XRCC5; ATP-dependent DNA helicase 2 subunit 2
E 100210864 DNA-dependent protein kinase catalytic subunit K06642 PRKDC; DNA-dependent protein kinase catalytic subunit [EC:2.7.11.1]
D MRX complex
E 100215233 double-strand break repair protein MRE11-like K10865 MRE11; double-strand break repair protein MRE11
D DNA Ligase 4 complex
E 100212302 DNA ligase 4 K10777 LIG4; DNA ligase 4 [EC:6.5.1.1]
E 100197379 DNA repair protein XRCC4 isoform X1 K10886 XRCC4; DNA-repair protein XRCC4
E 100212411 non-homologous end-joining factor 1 isoform X1 K10980 NHEJ1; non-homologous end-joining factor 1
D X-family DNA polymerases
D Other NHEJ factors
E 100206030 aprataxin K10863 APTX; aprataxin [EC:3.6.1.70 3.6.1.71 3.6.1.72]
E 101235320 aprataxin and PNK-like factor isoform X1 K13295 APLF; aprataxin and PNK-like factor [EC:3.1.-.-]
E 101239845 tyrosyl-DNA phosphodiesterase 2 K19619 TDP2; tyrosyl-DNA phosphodiesterase 2 [EC:3.1.4.-]
E 105849375 PWWP domain-containing DNA repair factor 3B-like isoform X1 K23386 PWWP3; PWWP domain-containing DNA repair factor 3
C FA (Fanconi anemia) pathway
D FA core complex
E 100210454 uncharacterized protein LOC100210454 K10893 FANCF; fanconi anemia group F protein
E 105847408 Fanconi anemia group M protein isoform X1 K10896 FANCM; fanconi anemia group M protein
E 100200972 Fanconi anemia core complex-associated protein 24 K10898 FAAP24; fanconi anemia-associated protein
D FA core complex binding factors
E 100207713 centromere protein S K11511 APITD1; centromere protein S
D Bloom's syndrome complex (BTR)
E 100205617 Bloom syndrome protein homolog K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 100213698 DNA topoisomerase 3-beta-1 isoform X1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 100202958 DNA topoisomerase 3-alpha isoform X1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 100215195 uncharacterized protein LOC100215195 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
D FANCD2-I complex
E 101235941 Fanconi anemia group I protein isoform X1 K10895 FANCI; fanconi anemia group I protein
D Downstream FA components
E 100213455 breast cancer type 1 susceptibility protein homolog isoform X1 K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 101237032 breast cancer type 2 susceptibility protein homolog isoform X1 K08775 BRCA2; breast cancer 2 susceptibility protein
D Other FA pathway factors
E 101239383 fanconi-associated nuclease 1 isoform X2 K15363 FAN1; fanconi-associated nuclease 1 [EC:3.1.21.- 3.1.4.1]
E 100204009 DNA repair protein RAD51 homolog A K04482 RAD51; DNA repair protein RAD51
E 100213046 DNA repair protein RAD51 homolog 3 isoform X1 K10870 RAD51L2; RAD51-like protein 2
E 101237927 telomere length regulation protein TEL2 homolog K11137 TELO2; telomere length regulation protein
E 100210616 WD repeat-containing protein 48 K15361 WDR48; WD repeat-containing protein 48
C Other DSBR factors
D Protein phosphatase 6
E 100207429 serine/threonine-protein phosphatase 6 catalytic subunit K15498 PPP6C; serine/threonine-protein phosphatase 6 catalytic subunit [EC:3.1.3.16]
E 101235774 serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A isoform X1 K15502 ANKRD28; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A
D Ubiquitin ligases
E 100215908 E3 ubiquitin-protein ligase rnf8 K10667 RNF8; E3 ubiquitin-protein ligase RNF8 [EC:2.3.2.27]
E 100215623 E3 ubiquitin-protein ligase rnf168 K20779 RNF168; E3 ubiquitin-protein ligase RNF168 [EC:2.3.2.31]
D Others
E 100200845 WD repeat-containing protein 70-like K24752 WDR70; WD repeat-containing protein 70
E 100204875 WD repeat-containing protein 76 K24755 WDR76; WD repeat-containing protein 76
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
D 101236651 DNA polymerase eta isoform X1 K03509 POLH; DNA polymerase eta [EC:2.7.7.7]
D 100197887 DNA polymerase kappa-like K03511 POLK; DNA polymerase kappa [EC:2.7.7.7]
D 100208934 DNA repair protein rev1 isoform X1 K03515 REV1; DNA repair protein REV1 [EC:2.7.7.-]
C B-family DNA polymerases
D 100213595 DNA polymerase zeta catalytic subunit isoform X1 K02350 REV3L; DNA polymerase zeta [EC:2.7.7.7]
C A-family DNA polymerase
C Rad6 epistasis group
D 100212855 ubiquitin-conjugating enzyme E2 A K10573 UBE2A; ubiquitin-conjugating enzyme E2 A [EC:2.3.2.23]
D 101241243 E3 ubiquitin-protein ligase RAD18 isoform X1 K10627 RAD18; E3 ubiquitin-protein ligase RAD18 [EC:2.3.2.27]
D 100209468 helicase-like transcription factor K15711 SMARCA3; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A3 [EC:5.6.2. 2.3.2.27]
D 100203605 ubiquitin-conjugating enzyme E2 variant 2 K10704 UBE2V; ubiquitin-conjugating enzyme E2 variant
D 100198598 ubiquitin-conjugating enzyme E2 N K10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23]
C Other TLS factors
D 100204143 proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
D 101239788 PCNA-interacting partner isoform X2 K27412 PARPBP; PCNA-interacting partner
D 100214851 DNA-dependent metalloprotease SPRTN K24051 SPRTN; SprT-like domain-contaning protein Spartan
D 100209980 germ cell nuclear acidic protein K26957 GCNA; germ cell nuclear acidic protein
B Check point factors
C Rad9-Hus1-Rad1 complex
D 100201992 cell cycle checkpoint control protein RAD9A K10994 RAD9A; cell cycle checkpoint control protein RAD9A [EC:3.1.11.2]
D 100214147 checkpoint protein HUS1 isoform X1 K10903 HUS1; HUS1 checkpoint protein
D 100199719 cell cycle checkpoint protein RAD1 isoform X1 K02830 HRAD1; cell cycle checkpoint protein [EC:3.1.11.2]
C HRAD17(Rad24)-RFC complex
D 100203270 cell cycle checkpoint protein RAD17 K06662 HRAD17; cell cycle checkpoint protein
D 100205184 replication factor C subunit 4 K10755 RFC2_4; replication factor C subunit 2/4
D 100199898 replication factor C subunit 2 isoform X1 K10755 RFC2_4; replication factor C subunit 2/4
D 100206290 replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
D 100208083 replication factor C subunit 5-like K10756 RFC3_5; replication factor C subunit 3/5
D 101236243 probable replication factor C subunit 5 K10756 RFC3_5; replication factor C subunit 3/5
C Rad17-Mec3-Ddc1 complex
D 100199719 cell cycle checkpoint protein RAD1 isoform X1 K02830 HRAD1; cell cycle checkpoint protein [EC:3.1.11.2]
C FPC (fork protection complex)
D 101240464 protein timeless homolog isoform X1 K10997 TIMELESS; replication fork protection complex subunit TIMELESS/Tof1/Swi1
D 101238352 TIMELESS-interacting protein K10998 TIPIN; replication fork protection complex subunit TIPIN/Csm3/Swi3
C Triple T complex
D 101237927 telomere length regulation protein TEL2 homolog K11137 TELO2; telomere length regulation protein
D 100198969 TELO2-interacting protein 1 homolog isoform X1 K20403 TTI1; TELO2-interacting protein 1
C BAG6-UBL4A-GET4 complex
D 100215156 large proline-rich protein bag6-A K23390 BAG6; large proline-rich protein BAG6
D 100211780 Golgi to ER traffic protein 4 homolog K23387 GET4; golgi to ER traffic protein 4
C Other check point factors
D 100199469 serine/threonine-protein kinase atr K06640 ATR; serine/threonine-protein kinase ATR [EC:2.7.11.1]
D 100201385 serine-protein kinase ATM isoform X1 K04728 ATM; serine-protein kinase ATM [EC:2.7.11.1]
D 100207213 cellular tumor antigen p53 K04451 TP53; tumor protein p53
D 100206960 serine/threonine-protein kinase Chk1 K02216 CHEK1; serine/threonine-protein kinase CHEK1 [EC:2.7.11.1]
D 100207948 myosin light chain kinase A-like K06641 CHEK2; serine/threonine-protein kinase CHEK2 [EC:2.7.11.1]
D 100214595 M-phase inducer phosphatase 1 K05866 CDC25B; M-phase inducer phosphatase 2 [EC:3.1.3.48]
D 100201221 14-3-3 protein zeta-like K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
D 100199424 14-3-3-like protein 1 K16198 YWHAG_H; 14-3-3 protein gamma/eta
D 100212336 14-3-3 protein gamma-like K16198 YWHAG_H; 14-3-3 protein gamma/eta
D 100209847 14-3-3-like protein isoform X1 K06630 YWHAE; 14-3-3 protein epsilon
D 101234863 wee1-like protein kinase isoform X1 K06632 WEE1; wee1-like protein kinase [EC:2.7.11.1]
D 100211251 uncharacterized protein LOC100211251 K20780 MDC1; mediator of DNA damage checkpoint protein 1
D 105843026 interferon-stimulated gene 20 kDa protein K18340 AEN; apoptosis-enhancing nuclease [EC:3.1.-.-]
D 100212063 serine/threonine-protein kinase Nek4 isoform X1 K08857 NEK1_4_5; serine/threonine-protein kinase Nek1/4/5 [EC:2.7.11.1]
D 101235086 serine/threonine-protein kinase Nek1-like isoform X1 K08857 NEK1_4_5; serine/threonine-protein kinase Nek1/4/5 [EC:2.7.11.1]
D 100213132 serine/threonine-protein kinase Nek10-like isoform X1 K20879 NEK10; serine/threonine-protein kinase Nek10 [EC:2.7.11.1]
D 101234974 protein downstream neighbor of Son K22422 DONSON; protein downstream neighbor of Son
D 100203056 uncharacterized protein LOC100203056 isoform X1 K22808 KANK; KN motif and ankyrin repeat domain-containing protein
D 100197636 vacuolar protein sorting-associated protein 4B K12196 VPS4; vacuolar protein-sorting-associated protein 4
D 100197788 vacuolar protein sorting-associated protein 4-like K12196 VPS4; vacuolar protein-sorting-associated protein 4
D 101241130 abscission/NoCut checkpoint regulator isoform X1 K24778 ZFYVE19; abscission/NoCut checkpoint regulator
D 100199516 replication stress response regulator SDE2 isoform X1 K25059 SDE2; replication stress response regulator SDE2
B Other factors with a suspected DNA repair function
C DNA polymerases
D 100199679 DNA polymerase theta isoform X1 K02349 POLQ; DNA polymerase theta [EC:2.7.7.7]
D 101238922 myb-binding protein 1A-like protein K02331 POL5; DNA polymerase phi [EC:2.7.7.7]
D 100207697 DNA-directed primase/polymerase protein K22761 PRIMPOL; DNA-directed primase/polymerase protein [EC:2.7.7.102 2.7.7.7]
C Nucleases
D 100203671 DNA cross-link repair 1A protein-like isoform X1 K15340 DCLRE1A; DNA cross-link repair 1A protein
D 100212622 endonuclease V K21813 ENDOV; endonuclease V [EC:3.1.26.-]
D 100199971 DNA annealing helicase and endonuclease ZRANB3 isoform X1 K25861 ZRANB3; DNA annealing helicase and endonuclease ZRANB3 [EC:5.6.2.- 3.1.-.-]
D 100213999 uncharacterized protein LOC100213999 K21411 ANKLE1; ankyrin repeat and LEM domain-containing protein 1
C Helicases
D 100199381 helicase POLQ-like isoform X1 K19178 HELQ; POLQ-like helicase [EC:5.6.2.4]
C PSO4 complex
D 100209788 pre-mRNA-processing factor 19 K10599 PRPF19; pre-mRNA-processing factor 19 [EC:2.3.2.27]
D 100215511 cell division cycle 5-related protein K12860 CDC5L; pre-mRNA-splicing factor CDC5/CEF1
D 101235723 pre-mRNA-splicing factor SPF27-like isoform X1 K12861 BCAS2; pre-mRNA-splicing factor SPF27
D 100211391 pleiotropic regulator 1 K12862 PLRG1; pleiotropic regulator 1
D 100212703 pre-mRNA-splicing factor PRP46 isoform X1 K12862 PLRG1; pleiotropic regulator 1
C Modulation of nucleotide pools
D 100204562 oxidized purine nucleoside triphosphate hydrolase K17816 NUDT1; 8-oxo-dGTP diphosphatase / 2-hydroxy-dATP diphosphatase [EC:3.6.1.55 3.6.1.56]
D 100210261 deoxyuridine 5'-triphosphate nucleotidohydrolase-like K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 100202439 deoxyuridine 5'-triphosphate nucleotidohydrolase-like K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 101237524 deoxyuridine 5'-triphosphate nucleotidohydrolase-like K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 100215820 deoxyuridine 5'-triphosphate nucleotidohydrolase-like K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 100214761 deoxyuridine 5'-triphosphate nucleotidohydrolase-like K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 101239981 deoxyuridine 5'-triphosphate nucleotidohydrolase-like K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 105845290 deoxyuridine 5'-triphosphate nucleotidohydrolase-like K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 100202966 deoxyuridine 5'-triphosphate nucleotidohydrolase-like K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 101241801 deoxyuridine 5'-triphosphate nucleotidohydrolase-like K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 100202999 ribonucleoside-diphosphate reductase large subunit K10807 RRM1; ribonucleoside-diphosphate reductase subunit M1 [EC:1.17.4.1]
D 100211917 ribonucleoside-diphosphate reductase subunit M2 B K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]
#
AProkaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D 100199101 methylated-DNA--protein-cysteine methyltransferase K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
C BER (base exicision repair)
D DNA glycosylases
E 100207347 uracil-DNA glycosylase isoform X1 K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E 100205662 adenine DNA glycosylase-like isoform X1 K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
E 100200675 endonuclease III-like protein 1 isoform X1 K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
D RecJ
D DNA ligase
D DNA polymerase I
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase complex (RNAP)
E TRCF (transcription-repair coupling factor)
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
D Molecular matchmaker
D Strand discrimination factor
D DNA exonucleases
D DNA polymerase III holoenzyme
D DNA ligase
D Other MMR factors
E 100200293 single-stranded DNA-binding protein, mitochondrial K03111 ssb; single-strand DNA-binding protein
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D RecBC pathway proteins
D RecFOR pathway proteins
D AddAB pathway proteins
D Other HR factor
D Archaeal homologous recombinant proteins
C NHEJ (non-homologous end-joining)
D Two-component NHEJ DNA repair complex
D SHIIR (short-homology-independent illegitimate recombination)
E Facilitator
E Supressor
D SHDIR (short-homology-dependent illegitimate recombination)
E RecET pathway
E Facilitator
E Supressor
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
C Other SOS response factors
D 100200293 single-stranded DNA-binding protein, mitochondrial K03111 ssb; single-strand DNA-binding protein
B Other factors with a suspected DNA repair function
C DNA polymerase
C DNA helicases
C Modulation of nucleotide pools
D 100210261 deoxyuridine 5'-triphosphate nucleotidohydrolase-like K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 100202439 deoxyuridine 5'-triphosphate nucleotidohydrolase-like K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 101237524 deoxyuridine 5'-triphosphate nucleotidohydrolase-like K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 100215820 deoxyuridine 5'-triphosphate nucleotidohydrolase-like K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 100214761 deoxyuridine 5'-triphosphate nucleotidohydrolase-like K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 101239981 deoxyuridine 5'-triphosphate nucleotidohydrolase-like K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 105845290 deoxyuridine 5'-triphosphate nucleotidohydrolase-like K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 100202966 deoxyuridine 5'-triphosphate nucleotidohydrolase-like K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 101241801 deoxyuridine 5'-triphosphate nucleotidohydrolase-like K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
C Others
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#
#[ BRITE | KEGG2 | KEGG ]
#Last updated: March 29, 2024