+C Two-component system KO
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Two-Component System - Hydrogenophaga pseudoflava
%
!
AOmpR family
B PhoR-PhoB (phosphate starvation response)
C HPF_14370 phoR3; Phosphate regulon sensor protein PhoR K07636 phoR; two-component system, OmpR family, phosphate regulon sensor histidine kinase PhoR [EC:2.7.13.3]
C HPF_14375 phoB2; Phosphate regulon transcriptional regulatory protein PhoB K07657 phoB; two-component system, OmpR family, phosphate regulon response regulator PhoB
C HPF_09895 walR; Transcriptional regulatory protein WalR K07658 phoB1; two-component system, OmpR family, alkaline phosphatase synthesis response regulator PhoP
B SenX3-RegX3 (phosphate starvation response)
B PhoQ-PhoP (magnesium transport)
B EnvZ-OmpR (osmotic stress response)
C HPF_10290 envZ; Osmolarity sensor protein EnvZ K07638 envZ; two-component system, OmpR family, osmolarity sensor histidine kinase EnvZ [EC:2.7.13.3]
C HPF_10295 ompR2; Transcriptional regulatory protein OmpR K07659 ompR; two-component system, OmpR family, phosphate regulon response regulator OmpR
B RstB-RstA
B CpxA-CpxR (envelope stress response)
B CssS-CssR (secretion stress response)
B CreC-CreB (phosphate regulation)
C HPF_08765 creC; Sensor protein CreC K07641 creC; two-component system, OmpR family, sensor histidine kinase CreC [EC:2.7.13.3]
C HPF_08760 creB; Transcriptional regulatory protein CreB K07663 creB; two-component system, OmpR family, catabolic regulation response regulator CreB
B BaeS-BaeR (envelope stress response)
B BasS-BasR (antimicrobial peptide resistance)
B CusS-CusR (copper tolerance)
C HPF_13865 cusS1; Sensor kinase CusS K07644 cusS; two-component system, OmpR family, heavy metal sensor histidine kinase CusS [EC:2.7.13.3]
C HPF_15325 cusS2; Sensor kinase CusS K07644 cusS; two-component system, OmpR family, heavy metal sensor histidine kinase CusS [EC:2.7.13.3]
C HPF_13860 copR1; Transcriptional activator protein CopR K07665 cusR; two-component system, OmpR family, copper resistance phosphate regulon response regulator CusR
C HPF_15330 copR2; Transcriptional activator protein CopR K07665 cusR; two-component system, OmpR family, copper resistance phosphate regulon response regulator CusR
B QseC-QseB (quorum sensing)
B KdpD-KdpE (potassium transport)
B TorS-TorR (TMAO respiration)
B ArcB-ArcA (anoxic redox control)
B TctE-TctD (tricarboxylic acid transport)
C HPF_09210 qseC2; Sensor protein QseC K07649 tctE; two-component system, OmpR family, sensor histidine kinase TctE [EC:2.7.13.3]
C HPF_15250 qseC6; Sensor protein QseC K07649 tctE; two-component system, OmpR family, sensor histidine kinase TctE [EC:2.7.13.3]
C HPF_03475 rssA1; Swarming motility regulation sensor protein RssA K07649 tctE; two-component system, OmpR family, sensor histidine kinase TctE [EC:2.7.13.3]
C HPF_09215 tctD1; Transcriptional regulatory protein tctD K07774 tctD; two-component system, OmpR family, response regulator TctD
C HPF_15245 tctD3; Transcriptional regulatory protein tctD K07774 tctD; two-component system, OmpR family, response regulator TctD
B ResE-ResD (aerobic and anaerobic respiration)
B VicK-VicR (cell wall metabolism)
B MprB-MprA (maintenance of persistent infection)
B MtrB-MtrA (osmotic stress response)
B PrrB-PrrA (intracellular multiplication)
B TrcS-TrcR
B NrsS-NrsR (nickel tolerance)
B ManS-ManR (manganese homeostasis)
B NblS-NblR (photosynthesis)
B SasA-RpaAB (circadian timing mediating)
B SaeS-SaeR (staphylococcal virulence regulation)
B BceS-BceR (bacitracin transport)
B BraS-BraR (bacitracin transport)
B GraS-GraR (cationic antimicrobial peptide transport)
B YxdK-YxdJ (antimicrobial peptide response)
B ChvG-ChvI (acidity sensing)
B CiaH-CiaR
B ParS-ParR (polymyxin-adaptive resistance)
B AdeS-AdeR
B VanS-VanR (VanB type vancomycin resistance)
B VanS-VanR (VanE type vancomycin resistance)
B VanS-VanR (actinomycete type vancomycin resistance)
B ArlS-ArlR (virulence regulation)
B Ihk-Irr (virulence regulation)
B PfeS-PfeR (enterobactin-dependent iron acquisition)
B NisK-NisR (lantibiotic biosynthesis)
B Unclassified
C HPF_21855 qseC8; Sensor protein QseC K02484 K02484; two-component system, OmpR family, sensor kinase [EC:2.7.13.3]
C HPF_11445 qseC3; Sensor protein QseC K02484 K02484; two-component system, OmpR family, sensor kinase [EC:2.7.13.3]
C HPF_11470 qseC4; Sensor protein QseC K02484 K02484; two-component system, OmpR family, sensor kinase [EC:2.7.13.3]
C HPF_08325 qseC1; Sensor protein QseC K02484 K02484; two-component system, OmpR family, sensor kinase [EC:2.7.13.3]
C HPF_01630 rstB1; Sensor protein RstB K02484 K02484; two-component system, OmpR family, sensor kinase [EC:2.7.13.3]
C HPF_22555 qseC9; Sensor protein QseC K02484 K02484; two-component system, OmpR family, sensor kinase [EC:2.7.13.3]
C HPF_21860 qseB4; Transcriptional regulatory protein QseB K02483 K02483; two-component system, OmpR family, response regulator
C HPF_11475 qseB3; Transcriptional regulatory protein QseB K02483 K02483; two-component system, OmpR family, response regulator
C HPF_22860 tctD4; Transcriptional regulatory protein tctD K02483 K02483; two-component system, OmpR family, response regulator
C HPF_22540 phoP3; Transcriptional regulatory protein PhoP K02483 K02483; two-component system, OmpR family, response regulator
C HPF_11440 qseB2; Transcriptional regulatory protein QseB K02483 K02483; two-component system, OmpR family, response regulator
C HPF_03470 basR; Transcriptional regulatory protein BasR K02483 K02483; two-component system, OmpR family, response regulator
C HPF_08160 baeR; Transcriptional regulatory protein BaeR K02483 K02483; two-component system, OmpR family, response regulator
C HPF_20630 phoP2; Virulence transcriptional regulatory protein PhoP K02483 K02483; two-component system, OmpR family, response regulator
C HPF_22560 qseB5; Transcriptional regulatory protein QseB K02483 K02483; two-component system, OmpR family, response regulator
C HPF_08330 qseB1; Transcriptional regulatory protein QseB K02483 K02483; two-component system, OmpR family, response regulator
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ANarL family
B NarX-NarL (nitrate respiration)
C HPF_02325 narX; Nitrate/nitrite sensor protein NarX K07673 narX; two-component system, NarL family, nitrate/nitrite sensor histidine kinase NarX [EC:2.7.13.3]
C HPF_02330 degU1; Transcriptional regulatory protein DegU K07684 narL; two-component system, NarL family, nitrate/nitrite response regulator NarL
B NarQ-NarP (nitrate respiration)
B UhpB-UhpA (hexose phosphates uptake)
C HPF_22015 liaS4; Sensor histidine kinase LiaS K07675 uhpB; two-component system, NarL family, sensor histidine kinase UhpB [EC:2.7.13.3]
C HPF_16455 liaS2; Sensor histidine kinase LiaS K07675 uhpB; two-component system, NarL family, sensor histidine kinase UhpB [EC:2.7.13.3]
B FusK-FusR (virulence regulation)
B RcsC-RcsD-RcsB (capsule synthesis)
B BarA-UvrY (central carbon metabolism)
C HPF_19275 uvrY2; Response regulator UvrY K07689 uvrY; two-component system, NarL family, invasion response regulator UvrY
C HPF_20400 uvrY3; Response regulator UvrY K07689 uvrY; two-component system, NarL family, invasion response regulator UvrY
C HPF_16450 uvrY1; Response regulator UvrY K07689 uvrY; two-component system, NarL family, invasion response regulator UvrY
C HPF_22010 uvrY4; Response regulator UvrY K07689 uvrY; two-component system, NarL family, invasion response regulator UvrY
B ComP-ComA (competence)
B EvgS-EvgA (acid and drug tolerance)
B DegS-DegU (multicellular behavior control)
B DesK-DesR (membrane lipid fluidity regulation)
B VraS-VraR (cell-wall peptidoglycan synthesis)
B LiaS-LiaR (cell wall stress response)
B DevS-DevR (redox response)
B NreB-NreC (dissimilatory nitrate/nitrite reduction)
B YdfH-YdfI
B SalK-SalR
B PprA–PprB (biofilm formation)
B Unclassified
#
ASpo family
B KinABCDE-Spo0FA (sporulation control)
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ACitB family
B CitA-CitB (citrate fermentation)
B CitS-CitT (magnesium-citrate transport)
B DcuS-DcuR (C4-dicarboxylate metabolism)
B DctS-DctR (C4-dicarboxylate transport)
B MalK-MalR (malate transport)
B Unclassified
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ALytTR family
B LysS-LysR
B AlgZ-AlgR (alginate production)
C HPF_19165 ypdA; Sensor histidine kinase YpdA K08082 algZ; two-component system, LytTR family, sensor histidine kinase AlgZ [EC:2.7.13.3]
C HPF_19160 ypdB; Transcriptional regulatory protein YpdB K08083 algR; two-component system, LytTR family, response regulator AlgR
B NatK-NatR (sodium extrusion)
B AgrC-AgrA (exoprotein synthesis)
B AgrC2-AgrA2 (virulence regulation)
B ComD-ComE (competence)
B Unclassified
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ANtrC family
B GlnL-GlnG (nitrogen regulation)
C HPF_17145 glnL; Nitrogen regulation protein NR(II) K07708 glnL; two-component system, NtrC family, nitrogen regulation sensor histidine kinase GlnL [EC:2.7.13.3]
C HPF_17140 glnG; Nitrogen regulation protein NR(I) K07712 glnG; two-component system, NtrC family, nitrogen regulation response regulator GlnG
B NtrY-NtrX (nitrogen regulation)
C HPF_21490 zraS2; Sensor protein ZraS K13598 ntrY; two-component system, NtrC family, nitrogen regulation sensor histidine kinase NtrY [EC:2.7.13.3]
C HPF_21485 spo0F; Sporulation initiation phosphotransferase F K13599 ntrX; two-component system, NtrC family, nitrogen regulation response regulator NtrX
B HydH-HydG (metal tolerance)
B AtoS-AtoC (cPHB biosynthesis)
B PilS-PilR (type 4 fimbriae synthesis)
C HPF_04210 zraS1; Sensor protein ZraS K02668 pilS; two-component system, NtrC family, sensor histidine kinase PilS [EC:2.7.13.3]
C HPF_04205 zraR2; Transcriptional regulatory protein ZraR K02667 pilR; two-component system, NtrC family, response regulator PilR
B GlrK-GlrR (amino sugar metabolism)
C HPF_04255 glrK; Sensor histidine kinase GlrK K07711 glrK; two-component system, NtrC family, sensor histidine kinase GlrK [EC:2.7.13.3]
C HPF_04245 qseF; Transcriptional regulatory protein QseF K07715 glrR; two-component system, NtrC family, response regulator GlrR
B PgtB-PgtA (phosphoglycerate transport)
B DctB-DctD (C4-dicarboxylate transport)
B KinB-AlgB (alginate production)
B HupT-HupR (hydrogenase synthesis regulation)
C HPF_01530 sensory histidine kinase AtoS K19661 hupT; two-component system, NtrC family, sensor histidine kinase HupT/HoxJ [EC:2.7.13.3]
C HPF_01490 hupR1; Hydrogenase transcriptional regulatory protein hupR1 K19641 hupR; two-component system, NtrC family, response regulator HupR/HoxA
C HPF_01485 enoyl-CoA hydratase K19640 hypX; putative two-component system protein, hydrogenase maturation factor HypX/HoxX
B Unclassified
C HPF_06765 dctB2; C4-dicarboxylate transport sensor protein DctB K02482 flgS; two-component system, NtrC family, sensor kinase [EC:2.7.13.3]
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ACheA family
B CheA-CheYBV (chemotaxis)
C HPF_20420 cheA; Chemotaxis protein CheA K03407 cheA; two-component system, chemotaxis family, sensor kinase CheA [EC:2.7.13.3]
C HPF_20275 cheY2; Chemotaxis protein CheY K03413 cheY; two-component system, chemotaxis family, chemotaxis protein CheY
C HPF_20415 cheY3; Chemotaxis protein CheY K03413 cheY; two-component system, chemotaxis family, chemotaxis protein CheY
C HPF_20435 cheB; Chemotaxis response regulator protein-glutamate methylesterase K03412 cheB; two-component system, chemotaxis family, protein-glutamate methylesterase/glutaminase [EC:3.1.1.61 3.5.1.44]
C HPF_18565 cheV; Chemotaxis protein CheV K03415 cheV; two-component system, chemotaxis family, chemotaxis protein CheV
B ChpA-ChpB/PilGH (chemosensory)
C HPF_04505 frzE; Gliding motility regulatory protein K06596 chpA; chemosensory pili system protein ChpA (sensor histidine kinase/response regulator)
C HPF_04485 yycF; Transcriptional regulatory protein YycF K02657 pilG; twitching motility two-component system response regulator PilG
C HPF_04490 phoB1; Phosphate regulon transcriptional regulatory protein PhoB K02658 pilH; twitching motility two-component system response regulator PilH
B PixL-PixGH (positive phototaxis)
B WspE-WspRF (chemosensory)
B Cph1-Rcp1 (light response)
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ACell cycle family
B PleC-PleD (cell fate control)
B CckA-CtrA/CpdR (cell cycle control)
C HPF_16185 Blue-light-activated protein K13587 cckA; two-component system, cell cycle sensor histidine kinase and response regulator CckA [EC:2.7.13.3]
C HPF_21325 Blue-light-activated protein K13587 cckA; two-component system, cell cycle sensor histidine kinase and response regulator CckA [EC:2.7.13.3]
B Hk1-Rrp1 (glycerol uptake and utilization)
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ALux family
B LuxQN/CqsS-LuxU-LuxO (quorum sensing)
C HPF_03390 cqsS; CAI-1 autoinducer sensor kinase/phosphatase CqsS K10916 cqsS; two-component system, CAI-1 autoinducer sensor kinase/phosphatase CqsS [EC:2.7.13.3 3.1.3.-]
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ALuxR family
B DctS-DctR (C4-dicarboxylate transport)
C HPF_05565 tmoS2; Sensor histidine kinase TmoS K11711 dctS; two-component system, LuxR family, sensor histidine kinase DctS [EC:2.7.13.3]
C HPF_22690 fixL4; Sensor protein FixL K11711 dctS; two-component system, LuxR family, sensor histidine kinase DctS [EC:2.7.13.3]
C HPF_05560 tdiR1; Transcriptional regulatory protein TdiR K11712 dctR; two-component system, LuxR family, response regulator DctR
C HPF_22685 tdiR2; Transcriptional regulatory protein TdiR K11712 dctR; two-component system, LuxR family, response regulator DctR
B TtrS-TtrR (tetrathionate respiration)
B FixL-FixJ (nitrogen fixation)
C HPF_20835 fixJ; Transcriptional regulatory protein FixJ K14987 fixJ; two-component system, LuxR family, response regulator FixJ
B SsrA-SsrB
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AOther families
B FlrB-FlrC (polar flagellar synthesis)
B AauS-AauR (acidic amino acids utilization)
C HPF_05815 dctD; C4-dicarboxylate transport transcriptional regulatory protein DctD K17061 aauR; two-component system, response regulator AauR
B SLN1-YPD1-SSK1/SKN7 (osmosensing)
B RpfC-RpfG (cell-to-cell signaling)
B GlnK-GlnL (glutamine utilization)
B HspS-HspR (hexose phosphates uptake)
B YesM-YesN
B CikA
B RegB-RegA (redox response)
C HPF_06335 regB; Sensor histidine kinase RegB K15011 regB; two-component system, sensor histidine kinase RegB [EC:2.7.13.3]
C HPF_06340 regA; Photosynthetic apparatus regulatory protein RegA K15012 regA; two-component system, response regulator RegA
B FitF-FitH (insecticidal toxin regulation)
B PhcS-PhcRQ
C HPF_03195 fixL2; Sensor protein FixL K19621 phcS; two-component system, sensor histidine kinase PhcS [EC:2.7.13.3]
C HPF_03200 hupR2; Hydrogenase transcriptional regulatory protein hupR1 K19622 phcR; two-component system, response regulator PhcR
C HPF_03205 hupR3; Hydrogenase transcriptional regulatory protein hupR1 K19623 phcQ; two-component system, probable response regulator PhcQ
B SagS-HptB-HsbR (swarming activity and biofilm formation)
B PdtaS-PdtaR
C HPF_17760 pdtaS; putative sensor histidine kinase pdtaS K00936 pdtaS; two-component system, sensor histidine kinase PdtaS [EC:2.7.13.3]
B NasS-NasT
B Unclassified
C HPF_19885 adrA; putative diguanylate cyclase AdrA K20971 ladS; two-component system, sensor histidine kinase LadS
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: December 14, 2023