+F	Repair protein	KO
#<h2><a href="/kegg/brite.html"><img src="/Fig/bget/kegg3.gif" align="middle" border=0></a>&nbsp; DNA Repair and Recombination Proteins - Halosimplex rubrum</h2>
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A<b>Eukaryotic type</b>
B  SSBR (single strand breaks repair)
C    Direct repair
D      HZS55_08500 methylated-DNA--[protein]-cysteine S-methyltransferase	K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63] 
D      HZS55_17830 deoxyribodipyrimidine photo-lyase	K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3] 
D      HZS55_19885 deoxyribodipyrimidine photo-lyase	K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3] 
C    BER (base exicision repair)
D      DNA glycosylases
E        HZS55_19910 A/G-specific adenine glycosylase	K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31] 
E        HZS55_10075 8-oxoguanine DNA glycosylase	K03660 OGG1; N-glycosylase/DNA lyase [EC:3.2.2.- 4.2.99.18] 
E        HZS55_11610 endonuclease III	K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18] 
E        HZS55_21755 nth; endonuclease III	K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18] 
D      AP endonucleases
D      Long Patch-BER factors
E        DNA polymerase delta complex
E        DNA polymerase epsilon complex
E        HZS55_04050 DNA polymerase sliding clamp	K04802 PCNA; proliferating cell nuclear antigen 
E        HZS55_00780 fen; flap endonuclease-1	K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-] 
E        HZS55_18585 ATP-dependent DNA ligase	K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7] 
D      Short Patch-BER factors
D      Other BER factors
C    NER (nucleotide excision repair)
D      GGR (global genome repair) factors
E        XPC-HR23B-CETN2 complex
E        Cul4-DDB2 complex
E        NER4 complex
D      TCR (transcription coupled repair) factors
E        DNA-directed RNA polymerase II complex
E        Cul4-CSA complex
E        Other TCR factor
D      TFIIH complex
E        HZS55_16715 DEAD/DEAH box helicase	K10843 ERCC3; DNA excision repair protein ERCC-3 [EC:5.6.2.4] 
E        HZS55_01040 ATP-dependent DNA helicase	K10844 ERCC2; DNA excision repair protein ERCC-2 [EC:5.6.2.3] 
E        HZS55_03640 ATP-dependent DNA helicase	K10844 ERCC2; DNA excision repair protein ERCC-2 [EC:5.6.2.3] 
D      RPA (replication factor A)
E        HZS55_20880 single-stranded DNA binding protein	K07466 RFA1; replication factor A1 
D      Other NER factors
E        HZS55_18585 ATP-dependent DNA ligase	K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7] 
C    MMR (mismatch excision repair)
D      Mismatch and loop recognition factors
D      MutL homologs
D      DNA polymerase delta complex
D      RPA (replication factor A)
E        HZS55_20880 single-stranded DNA binding protein	K07466 RFA1; replication factor A1 
D      RFC (replication factor C)
D      Other MMR factors
E        HZS55_04050 DNA polymerase sliding clamp	K04802 PCNA; proliferating cell nuclear antigen 
E        HZS55_18585 ATP-dependent DNA ligase	K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7] 
B  DSBR (double strand breaks repair)
C    HR (homologous recombination)
D      MRN(MRX) complex
D      BRCA1-core complex
D      BRCA1-A complex
D      BRCA1-B complex
D      BRCA1-C complex
D      BRCA complex
D      RecA family proteins
D      Rad52 family proteins
D      Rad54 family proteins
D      RecQ family DNA helicases
D      Bloom's syndrome complex (BTR)
D      RPA (replication factor A)
E        HZS55_20880 single-stranded DNA binding protein	K07466 RFA1; replication factor A1 
D      Protein phosphatase 4
D      AP-5 complex
D      SMC5-SMC6 complex
D      Other HR factors
C    NHEJ (non-homologous end-joining)
D      DNA-PK complex
D      MRX complex
D      DNA Ligase 4 complex
D      X-family DNA polymerases
D      Other NHEJ factors
C    FA (Fanconi anemia) pathway
D      FA core complex
D      FA core complex binding factors
D      Bloom's syndrome complex (BTR)
D      FANCD2-I complex
D      Downstream FA components
D      Other FA pathway factors
C    Other DSBR factors
D      Protein phosphatase 6
D      Ubiquitin ligases
D      Others
B  TLS (translesion DNA synthesis) factors
C    Y-family DNA polymerases
C    B-family DNA polymerases
C    A-family DNA polymerase
C    Rad6 epistasis group
C    Other TLS factors
D      HZS55_04050 DNA polymerase sliding clamp	K04802 PCNA; proliferating cell nuclear antigen 
B  Check point factors
C    Rad9-Hus1-Rad1 complex
C    HRAD17(Rad24)-RFC complex
C    Rad17-Mec3-Ddc1 complex
C    FPC (fork protection complex)
C    Triple T complex
C    BAG6-UBL4A-GET4 complex
C    Other check point factors
B  Other factors with a suspected DNA repair function
C    DNA polymerases
C    Nucleases
C    Helicases
C    PSO4 complex
C    Modulation of nucleotide pools
D      HZS55_11865 NUDIX domain-containing protein	K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55] 
D      HZS55_03450 NUDIX hydrolase	K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55] 
D      HZS55_03805 NUDIX domain-containing protein	K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55] 
D      HZS55_05015 NUDIX domain-containing protein	K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55] 
D      HZS55_11465 NUDIX hydrolase	K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55] 
D      HZS55_06180 NUDIX hydrolase	K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55] 
D      HZS55_08950 NUDIX hydrolase	K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55] 
D      HZS55_18605 NUDIX hydrolase	K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55] 
D      HZS55_16950 NUDIX domain-containing protein	K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55] 
D      HZS55_21860 NUDIX hydrolase	K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55] 
D      HZS55_00430 deoxyuridine 5'-triphosphate nucleotidohydrolase	K01520 dut; dUTP diphosphatase [EC:3.6.1.23] 
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A<b>Prokaryotic type</b>
B  SSBR (single strand breaks repair)
C    Direct repair
D      HZS55_08500 methylated-DNA--[protein]-cysteine S-methyltransferase	K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63] 
D      HZS55_17830 deoxyribodipyrimidine photo-lyase	K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3] 
D      HZS55_19885 deoxyribodipyrimidine photo-lyase	K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3] 
D      HZS55_08365 cryptochrome/photolyase family protein	K06876 phrB; (6-4)DNA photolyase [EC:4.1.99.13] 
C    BER (base exicision repair)
D      DNA glycosylases
E        HZS55_02715 uracil-DNA glycosylase	K21929 udg; uracil-DNA glycosylase [EC:3.2.2.27] 
E        HZS55_13455 uracil-DNA glycosylase	K21929 udg; uracil-DNA glycosylase [EC:3.2.2.27] 
E        HZS55_17655 DNA-3-methyladenine glycosylase 2 family protein	K01247 alkA; DNA-3-methyladenine glycosylase II [EC:3.2.2.21] 
E        HZS55_19910 A/G-specific adenine glycosylase	K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31] 
E        HZS55_11610 endonuclease III	K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18] 
E        HZS55_21755 nth; endonuclease III	K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18] 
D      AP endonucleases
E        HZS55_07640 deoxyribonuclease IV	K01151 nfo; deoxyribonuclease IV [EC:3.1.21.2] 
E        HZS55_00875 endonuclease V	K05982 E3.1.21.7; deoxyribonuclease V [EC:3.1.21.7] 
D      RecJ
E        HZS55_04120 DHH family phosphoesterase	K07462 recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-] 
D      DNA ligase
E        HZS55_21075 ligA; NAD-dependent DNA ligase LigA	K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2] 
D      DNA polymerase I
C    NER (nucleotide excision repair)
D      GGR (global genome repair) factors
E        HZS55_21810 uvrA; excinuclease ABC subunit UvrA	K03701 uvrA; excinuclease ABC subunit A 
E        HZS55_07255 uvrB; excinuclease ABC subunit UvrB	K03702 uvrB; excinuclease ABC subunit B 
E        HZS55_21040 excinuclease ABC subunit C	K03703 uvrC; excinuclease ABC subunit C 
E        HZS55_01045 ATP-dependent helicase	K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4] 
E        HZS55_21075 ligA; NAD-dependent DNA ligase LigA	K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2] 
D      TCR (transcription coupled repair) factors
E        DNA-directed RNA polymerase complex (RNAP)
E        TRCF (transcription-repair coupling factor)
C    MMR (mismatch excision repair)
D      Mismatch and loop recognition factors
E        HZS55_09980 mutS; DNA mismatch repair protein MutS	K03555 mutS; DNA mismatch repair protein MutS 
E        HZS55_22155 mutS; DNA mismatch repair protein MutS	K03555 mutS; DNA mismatch repair protein MutS 
E        HZS55_02930 endonuclease MutS2	K07456 mutS2; DNA mismatch repair protein MutS2 
E        HZS55_16740 DNA mismatch repair protein	K07456 mutS2; DNA mismatch repair protein MutS2 
D      Molecular matchmaker
E        HZS55_21855 mutL; DNA mismatch repair endonuclease MutL	K03572 mutL; DNA mismatch repair protein MutL 
D      Strand discrimination factor
D      DNA exonucleases
D      DNA polymerase III holoenzyme
D      DNA ligase
E        HZS55_21075 ligA; NAD-dependent DNA ligase LigA	K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2] 
D      Other MMR factors
E        HZS55_01045 ATP-dependent helicase	K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4] 
B  DSBR (double strand breaks repair)
C    HR (homologous recombination)
D      RecBC pathway proteins
E        HZS55_20505 DNA double-strand break repair ATPase Rad50	K03546 sbcC; DNA repair protein SbcC/Rad50 
E        HZS55_03240 metallophosphoesterase family protein	K03547 sbcD; DNA repair protein SbcD/Mre11 
E        HZS55_20510 metallophosphoesterase family protein	K03547 sbcD; DNA repair protein SbcD/Mre11 
D      RecFOR pathway proteins
E        HZS55_04120 DHH family phosphoesterase	K07462 recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-] 
D      AddAB pathway proteins
D      Other HR factor
E        HZS55_09730 cas1b; type I-B CRISPR-associated endonuclease Cas1	K15342 cas1; CRISP-associated protein Cas1 
D      Archaeal homologous recombinant proteins
E        HZS55_01385 radA; DNA repair and recombination protein RadA	K04483 radA; DNA repair protein RadA 
E        HZS55_12435 radB; DNA repair and recombination protein RadB	K04484 radB; DNA repair protein RadB 
E        HZS55_02635 nucleoid-structuring protein H-NS	K03552 hjr; holliday junction resolvase [EC:3.1.21.10] 
E        HZS55_20505 DNA double-strand break repair ATPase Rad50	K03546 sbcC; DNA repair protein SbcC/Rad50 
E        HZS55_03240 metallophosphoesterase family protein	K03547 sbcD; DNA repair protein SbcD/Mre11 
E        HZS55_20510 metallophosphoesterase family protein	K03547 sbcD; DNA repair protein SbcD/Mre11 
E        HZS55_01180 ATP-dependent DNA helicase	K03726 helS; ATP-dependent DNA helicase [EC:5.6.2.4] 
C    NHEJ (non-homologous end-joining)
D      Two-component NHEJ DNA repair complex
D      SHIIR (short-homology-independent illegitimate recombination)
E        Facilitator
F          HZS55_17355 gyrA; DNA gyrase subunit A	K02469 gyrA; DNA gyrase subunit A [EC:5.6.2.2] 
F          HZS55_17360 gyrB; DNA topoisomerase (ATP-hydrolyzing) subunit B	K02470 gyrB; DNA gyrase subunit B [EC:5.6.2.2] 
F          HZS55_04550 DUF91 domain-containing protein	K03168 topA; DNA topoisomerase I [EC:5.6.2.1] 
F          HZS55_08780 DNA topoisomerase I	K03168 topA; DNA topoisomerase I [EC:5.6.2.1] 
E        Supressor
D      SHDIR (short-homology-dependent illegitimate recombination)
E        RecET pathway
F          HZS55_04120 DHH family phosphoesterase	K07462 recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-] 
F          HZS55_21075 ligA; NAD-dependent DNA ligase LigA	K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2] 
E        Facilitator
E        Supressor
F          HZS55_21810 uvrA; excinuclease ABC subunit UvrA	K03701 uvrA; excinuclease ABC subunit A 
F          HZS55_07255 uvrB; excinuclease ABC subunit UvrB	K03702 uvrB; excinuclease ABC subunit B 
B  TLS (translesion DNA synthesis) factors
C    Y-family DNA polymerases
D      HZS55_15255 dinB; DNA polymerase IV	K04479 dbh; DNA polymerase IV (archaeal DinB-like DNA polymerase) [EC:2.7.7.7] 
C    Other SOS response factors
B  Other factors with a suspected DNA repair function
C    DNA polymerase
D      HZS55_20655 polX; DNA polymerase/3'-5' exonuclease PolX	K02347 polX; DNA polymerase (family X) 
C    DNA helicases
D      HZS55_17920 ATP-dependent helicase	K03724 lhr; ATP-dependent helicase Lhr and Lhr-like helicase [EC:5.6.2.6 5.6.2.4] 
D      HZS55_17620 DEAD/DEAH box helicase	K03724 lhr; ATP-dependent helicase Lhr and Lhr-like helicase [EC:5.6.2.6 5.6.2.4] 
C    Modulation of nucleotide pools
D      HZS55_11865 NUDIX domain-containing protein	K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55] 
D      HZS55_03450 NUDIX hydrolase	K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55] 
D      HZS55_03805 NUDIX domain-containing protein	K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55] 
D      HZS55_05015 NUDIX domain-containing protein	K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55] 
D      HZS55_11465 NUDIX hydrolase	K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55] 
D      HZS55_06180 NUDIX hydrolase	K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55] 
D      HZS55_08950 NUDIX hydrolase	K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55] 
D      HZS55_18605 NUDIX hydrolase	K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55] 
D      HZS55_16950 NUDIX domain-containing protein	K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55] 
D      HZS55_21860 NUDIX hydrolase	K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55] 
D      HZS55_00430 deoxyuridine 5'-triphosphate nucleotidohydrolase	K01520 dut; dUTP diphosphatase [EC:3.6.1.23] 
D      HZS55_10280 adenosylcobalamin-dependent ribonucleoside-diphosphate reductase	K00525 E1.17.4.1A; ribonucleoside-diphosphate reductase alpha chain [EC:1.17.4.1] 
D      HZS55_07265 ribonucleoside-diphosphate reductase subunit alpha	K00525 E1.17.4.1A; ribonucleoside-diphosphate reductase alpha chain [EC:1.17.4.1] 
D      HZS55_07270 ribonucleotide-diphosphate reductase subunit beta	K00526 E1.17.4.1B; ribonucleoside-diphosphate reductase beta chain [EC:1.17.4.1] 
C    Others
D      HZS55_11195 hypothetical protein	K22585 nreA; DNA repair protein NreA 
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#Last updated: March 29, 2024