+E Proteasome KO
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Proteasome - Homo sapiens (human)
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AEukaryotic proteasome
B Core particles (20S proteasome)
C alpha type subunits
D 5687 PSMA6; proteasome subunit alpha type-6 isoform a K02730 PSMA6; 20S proteasome subunit alpha 1 [EC:3.4.25.1]
D 5683 PSMA2; proteasome subunit alpha type-2 K02726 PSMA2; 20S proteasome subunit alpha 2 [EC:3.4.25.1]
D 5685 PSMA4; proteasome subunit alpha type-4 isoform 1 K02728 PSMA4; 20S proteasome subunit alpha 3 [EC:3.4.25.1]
D 143471 PSMA8; proteasome subunit alpha-type 8 isoform 1 K02731 PSMA7; 20S proteasome subunit alpha 4 [EC:3.4.25.1]
D 5688 PSMA7; proteasome subunit alpha type-7 K02731 PSMA7; 20S proteasome subunit alpha 4 [EC:3.4.25.1]
D 5686 PSMA5; proteasome subunit alpha type-5 isoform 1 K02729 PSMA5; 20S proteasome subunit alpha 5 [EC:3.4.25.1]
D 5682 PSMA1; proteasome subunit alpha type-1 isoform 2 K02725 PSMA1; 20S proteasome subunit alpha 6 [EC:3.4.25.1]
D 5684 PSMA3; proteasome subunit alpha type-3 isoform 1 K02727 PSMA3; 20S proteasome subunit alpha 7 [EC:3.4.25.1]
C beta type subunits
D 5694 PSMB6; proteasome subunit beta type-6 isoform 1 K02738 PSMB6; 20S proteasome subunit beta 1 [EC:3.4.25.1]
D 5695 PSMB7; proteasome subunit beta type-7 precursor K02739 PSMB7; 20S proteasome subunit beta 2 [EC:3.4.25.1]
D 5691 PSMB3; proteasome subunit beta type-3 K02735 PSMB3; 20S proteasome subunit beta 3 [EC:3.4.25.1]
D 5690 PSMB2; proteasome subunit beta type-2 isoform 1 K02734 PSMB2; 20S proteasome subunit beta 4 [EC:3.4.25.1]
D 5693 PSMB5; proteasome subunit beta type-5 isoform 1 K02737 PSMB5; 20S proteasome subunit beta 5 [EC:3.4.25.1]
D 5689 PSMB1; proteasome subunit beta type-1 K02732 PSMB1; 20S proteasome subunit beta 6 [EC:3.4.25.1]
D 5692 PSMB4; proteasome subunit beta type-4 K02736 PSMB4; 20S proteasome subunit beta 7 [EC:3.4.25.1]
D 5696 PSMB8; proteasome subunit beta type-8 isoform E2 precursor K02740 PSMB8; 20S proteasome subunit beta 8 [EC:3.4.25.1]
D 5698 PSMB9; proteasome subunit beta type-9 precursor K02741 PSMB9; 20S proteasome subunit beta 9 [EC:3.4.25.1]
D 5699 PSMB10; proteasome subunit beta type-10 K02733 PSMB10; 20S proteasome subunit beta 10 [EC:3.4.25.1]
D 122706 PSMB11; proteasome subunit beta type-11 K11598 PSMB11; 20S proteasome subunit beta 11 [EC:3.4.25.1]
B Regulatory particles
C PA700 (19S proteasome)
D ATPase subunits
E 5701 PSMC2; 26S proteasome regulatory subunit 7 isoform 1 K03061 PSMC2; 26S proteasome regulatory subunit T1
E 5700 PSMC1; 26S proteasome regulatory subunit 4 isoform a K03062 PSMC1; 26S proteasome regulatory subunit T2
E 5704 PSMC4; 26S proteasome regulatory subunit 6B isoform 1 K03063 PSMC4; 26S proteasome regulatory subunit T3
E 5706 PSMC6; 26S proteasome regulatory subunit 10B isoform 1 K03064 PSMC6; 26S proteasome regulatory subunit T4
E 5702 PSMC3; 26S proteasome regulatory subunit 6A K03065 PSMC3; 26S proteasome regulatory subunit T5
E 5705 PSMC5; 26S proteasome regulatory subunit 8 isoform 1 K03066 PSMC5; 26S proteasome regulatory subunit T6
D non-ATPase subunits
E 5708 PSMD2; 26S proteasome non-ATPase regulatory subunit 2 isoform 1 K03028 PSMD2; 26S proteasome regulatory subunit N1
E 5707 PSMD1; 26S proteasome non-ATPase regulatory subunit 1 isoform 1 K03032 PSMD1; 26S proteasome regulatory subunit N2
E 5709 PSMD3; 26S proteasome non-ATPase regulatory subunit 3 K03033 PSMD3; 26S proteasome regulatory subunit N3
E 5715 PSMD9; 26S proteasome non-ATPase regulatory subunit 9 isoform 1 K06693 PSMD9; 26S proteasome regulatory subunit N4
E 5718 PSMD12; 26S proteasome non-ATPase regulatory subunit 12 isoform 1 K03035 PSMD12; 26S proteasome regulatory subunit N5
E 5717 PSMD11; 26S proteasome non-ATPase regulatory subunit 11 K03036 PSMD11; 26S proteasome regulatory subunit N6
E 9861 PSMD6; 26S proteasome non-ATPase regulatory subunit 6 isoform 2 K03037 PSMD6; 26S proteasome regulatory subunit N7
E 5713 PSMD7; 26S proteasome non-ATPase regulatory subunit 7 K03038 PSMD7; 26S proteasome regulatory subunit N8
E 5719 PSMD13; 26S proteasome non-ATPase regulatory subunit 13 isoform 1 K03039 PSMD13; 26S proteasome regulatory subunit N9
E 5710 PSMD4; 26S proteasome non-ATPase regulatory subunit 4 isoform 2 K03029 PSMD4; 26S proteasome regulatory subunit N10
E 10213 PSMD14; 26S proteasome non-ATPase regulatory subunit 14 K03030 PSMD14; 26S proteasome regulatory subunit N11
E 5714 PSMD8; 26S proteasome non-ATPase regulatory subunit 8 K03031 PSMD8; 26S proteasome regulatory subunit N12
E 11047 ADRM1; proteasomal ubiquitin receptor ADRM1 isoform 1 K06691 RPN13; 26S proteasome regulatory subunit N13
E 7979 SEM1; 26S proteasome complex subunit SEM1 isoform c K10881 SHFM1; 26 proteasome complex subunit DSS1
E 5711 PSMD5; 26S proteasome non-ATPase regulatory subunit 5 isoform 1 K06692 PSMD5; 26S proteasome non-ATPase regulatory subunit 5
E 5716 PSMD10; 26S proteasome non-ATPase regulatory subunit 10 isoform 1 K06694 PSMD10; 26S proteasome non-ATPase regulatory subunit 10
C PA28 (11S REG)
D 5720 PSME1; proteasome activator complex subunit 1 isoform 1 K06696 PSME1; proteasome activator subunit 1 (PA28 alpha)
D 5721 PSME2; proteasome activator complex subunit 2 K06697 PSME2; proteasome activator subunit 2 (PA28 beta)
D 10197 PSME3; proteasome activator complex subunit 3 isoform 1 K06698 PSME3; proteasome activator subunit 3 (PA28 gamma)
C PA200
D 23198 PSME4; proteasome activator complex subunit 4 K06699 PSME4; proteasome activator subunit 4
C PI31
D 9491 PSMF1; proteasome inhibitor PI31 subunit isoform 1 K06700 PSMF1; proteasome inhibitor subunit 1 (PI31)
B Assembling factors
C Assembling chaperones
D 51371 POMP; proteasome maturation protein K11599 POMP; proteasome maturation protein
D 8624 PSMG1; proteasome assembly chaperone 1 isoform a K11875 PSMG1; proteasome assembly chaperone 1
D 56984 PSMG2; proteasome assembly chaperone 2 isoform 1 K11876 PSMG2; proteasome assembly chaperone 2
D 84262 PSMG3; proteasome assembly chaperone 3 K11877 PSMG3; proteasome assembly chaperone 3
D 389362 PSMG4; proteasome assembly chaperone 4 isoform b K11878 PSMG4; proteasome assembly chaperone 4
C Other assembling factors
D 3646 EIF3E; eukaryotic translation initiation factor 3 subunit E K03250 EIF3E; translation initiation factor 3 subunit E
D 3303 HSPA1A; heat shock 70 kDa protein 1A K03283 HSPA1_6_8; heat shock 70kDa protein 1/6/8
D 3304 HSPA1B; heat shock 70 kDa protein 1B K03283 HSPA1_6_8; heat shock 70kDa protein 1/6/8
D 3305 HSPA1L; heat shock 70 kDa protein 1-like K03283 HSPA1_6_8; heat shock 70kDa protein 1/6/8
D 3310 HSPA6; heat shock 70 kDa protein 6 K03283 HSPA1_6_8; heat shock 70kDa protein 1/6/8
D 3312 HSPA8; heat shock cognate 71 kDa protein isoform 1 K03283 HSPA1_6_8; heat shock 70kDa protein 1/6/8
D 3306 HSPA2; heat shock-related 70 kDa protein 2 K26598 HSPA2; heat shock 70kDa protein 2
D 3320 HSP90AA1; heat shock protein HSP 90-alpha isoform 2 K04079 HSP90A; molecular chaperone HtpG
D 3326 HSP90AB1; heat shock protein HSP 90-beta isoform a K04079 HSP90A; molecular chaperone HtpG
D 3458 IFNG; interferon gamma precursor K04687 IFNG; interferon gamma
D 28987 NOB1; RNA-binding protein NOB1 K11883 NOB1; RNA-binding protein NOB1
D 56902 PNO1; RNA-binding protein PNO1 isoform 1 K11884 PNO1; RNA-binding protein PNO1
B Proteasome interacting proteins (PIPs)
C UBL-UBA shuttle proteins
D 5886 RAD23A; UV excision repair protein RAD23 homolog A isoform 1 K10839 RAD23; UV excision repair protein RAD23
D 5887 RAD23B; UV excision repair protein RAD23 homolog B isoform 1 K10839 RAD23; UV excision repair protein RAD23
D 29978 UBQLN2; ubiquilin-2 K04523 UBQLN; ubiquilin
D 29979 UBQLN1; ubiquilin-1 isoform 1 K04523 UBQLN; ubiquilin
D 50613 UBQLN3; ubiquilin-3 K04523 UBQLN; ubiquilin
D 56893 UBQLN4; ubiquilin-4 isoform 1 K04523 UBQLN; ubiquilin
D 143630 UBQLNL; ubiquilin-like protein K22254 UBQLNL; ubiquilin-like protein
D 414301 DDI1; protein DDI1 homolog 1 K11885 DDI; DNA damage-inducible protein [EC:3.4.23.-]
D 84301 DDI2; protein DDI1 homolog 2 K11885 DDI; DNA damage-inducible protein [EC:3.4.23.-]
D 51667 NUB1; NEDD8 ultimate buster 1 isoform 1 K29014 NUB1; NEDD8 ultimate buster 1
C Other PIPs
D 23392 ECPAS; proteasome adapter and scaffold protein ECM29 isoform 4 K11886 ECM29; proteasome component ECM29
D 80227 PAAF1; proteasomal ATPase-associated factor 1 isoform 2 K11887 PAAF1; proteasomal ATPase-associated factor 1
D 29893 PSMC3IP; homologous-pairing protein 2 homolog isoform 2 K06695 PSMC3IP; 26S proteasome regulatory subunit, ATPase 3, interacting protein
D 51528 JKAMP; JNK1/MAPK8-associated membrane protein isoform 1 K28966 JKAMP; JNK1/MAPK8-associated membrane protein
D 90007 MIDN; midnolin isoform 2 K29091 MIDN; midnolin
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AProkaryotic proteasome
B Core particles (20S proteasome)
B Bacterial regulatory particles
B Archaeal regulatory particles
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: July 7, 2026