+F	Repair protein	KO
#<h2><a href="/kegg/brite.html"><img src="/Fig/bget/kegg3.gif" align="middle" border=0></a>&nbsp; DNA Repair and Recombination Proteins - Hymenobacter sp. DG25B</h2>
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A<b>Eukaryotic type</b>
B  SSBR (single strand breaks repair)
C    Direct repair
D      PK28_08190 deoxyribodipyrimidine photolyase	K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3] 
C    BER (base exicision repair)
D      DNA glycosylases
E        PK28_13595 uracil-DNA glycosylase	K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27] 
E        PK28_15795 3-methyladenine DNA glycosylase	K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21] 
E        PK28_03880 adenine glycosylase	K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31] 
E        PK28_05380 Fe-S cluster assembly protein HesB	K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18] 
E        PK28_14585 endonuclease III	K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18] 
E        PK28_03915 endonuclease III	K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18] 
D      AP endonucleases
D      Long Patch-BER factors
E        DNA polymerase delta complex
E        DNA polymerase epsilon complex
D      Short Patch-BER factors
D      Other BER factors
C    NER (nucleotide excision repair)
D      GGR (global genome repair) factors
E        XPC-HR23B-CETN2 complex
E        Cul4-DDB2 complex
E        NER4 complex
D      TCR (transcription coupled repair) factors
E        DNA-directed RNA polymerase II complex
E        Cul4-CSA complex
E        Other TCR factor
D      TFIIH complex
D      RPA (replication factor A)
D      Other NER factors
C    MMR (mismatch excision repair)
D      Mismatch and loop recognition factors
D      MutL homologs
D      DNA polymerase delta complex
D      RPA (replication factor A)
D      RFC (replication factor C)
D      Other MMR factors
B  DSBR (double strand breaks repair)
C    HR (homologous recombination)
D      MRN(MRX) complex
D      BRCA1-core complex
D      BRCA1-A complex
D      BRCA1-B complex
D      BRCA1-C complex
D      BRCA complex
D      RecA family proteins
D      Rad52 family proteins
D      Rad54 family proteins
D      RecQ family DNA helicases
D      Bloom's syndrome complex (BTR)
D      RPA (replication factor A)
D      Protein phosphatase 4
D      AP-5 complex
D      SMC5-SMC6 complex
D      Other HR factors
C    NHEJ (non-homologous end-joining)
D      DNA-PK complex
D      MRX complex
D      DNA Ligase 4 complex
D      X-family DNA polymerases
D      Other NHEJ factors
C    FA (Fanconi anemia) pathway
D      FA core complex
D      FA core complex binding factors
D      Bloom's syndrome complex (BTR)
D      FANCD2-I complex
D      Downstream FA components
D      Other FA pathway factors
C    Other DSBR factors
D      Protein phosphatase 6
D      Ubiquitin ligases
D      Others
B  TLS (translesion DNA synthesis) factors
C    Y-family DNA polymerases
C    B-family DNA polymerases
C    A-family DNA polymerase
C    Rad6 epistasis group
C    Other TLS factors
B  Check point factors
C    Rad9-Hus1-Rad1 complex
C    HRAD17(Rad24)-RFC complex
C    Rad17-Mec3-Ddc1 complex
C    FPC (fork protection complex)
C    Triple T complex
C    BAG6-UBL4A-GET4 complex
C    Other check point factors
B  Other factors with a suspected DNA repair function
C    DNA polymerases
C    Nucleases
D      PK28_10850 hypothetical protein	K05986 NUCS; nuclease S1 [EC:3.1.30.1] 
C    Helicases
C    PSO4 complex
C    Modulation of nucleotide pools
D      PK28_16195 deoxyuridine 5'-triphosphate nucleotidohydrolase	K01520 dut; dUTP diphosphatase [EC:3.6.1.23] 
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A<b>Prokaryotic type</b>
B  SSBR (single strand breaks repair)
C    Direct repair
D      PK28_10870 6-O-methylguanine DNA methyltransferase	K10778 ada; AraC family transcriptional regulator, regulatory protein of adaptative response / methylated-DNA-[protein]-cysteine methyltransferase [EC:2.1.1.63] 
D      PK28_08190 deoxyribodipyrimidine photolyase	K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3] 
C    BER (base exicision repair)
D      DNA glycosylases
E        PK28_13595 uracil-DNA glycosylase	K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27] 
E        PK28_12710 Fe-S cluster assembly protein HesB	K01247 alkA; DNA-3-methyladenine glycosylase II [EC:3.2.2.21] 
E        PK28_15795 3-methyladenine DNA glycosylase	K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21] 
E        PK28_03880 adenine glycosylase	K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31] 
E        PK28_11465 hypothetical protein	K10563 mutM; formamidopyrimidine-DNA glycosylase [EC:3.2.2.23 4.2.99.18] 
E        PK28_05380 Fe-S cluster assembly protein HesB	K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18] 
E        PK28_14585 endonuclease III	K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18] 
E        PK28_03915 endonuclease III	K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18] 
D      AP endonucleases
E        PK28_01810 exodeoxyribonuclease III	K01142 E3.1.11.2; exodeoxyribonuclease III [EC:3.1.11.2] 
E        PK28_04845 endonuclease V	K05982 E3.1.21.7; deoxyribonuclease V [EC:3.1.21.7] 
D      RecJ
E        PK28_02000 recombinase RecJ	K07462 recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-] 
D      DNA ligase
E        PK28_09550 DNA ligase	K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2] 
D      DNA polymerase I
E        PK28_03125 DNA polymerase I	K02335 polA; DNA polymerase I [EC:2.7.7.7] 
C    NER (nucleotide excision repair)
D      GGR (global genome repair) factors
E        PK28_02750 excinuclease ABC subunit A	K03701 uvrA; excinuclease ABC subunit A 
E        PK28_03975 excinuclease ABC subunit A	K03701 uvrA; excinuclease ABC subunit A 
E        PK28_11840 excinuclease ABC subunit A	K03701 uvrA; excinuclease ABC subunit A 
E        PK28_15890 excinuclease ABC subunit B	K03702 uvrB; excinuclease ABC subunit B 
E        PK28_03365 excinuclease ABC subunit C	K03703 uvrC; excinuclease ABC subunit C 
E        PK28_17610 helicase	K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4] 
E        PK28_08805 ATP-dependent DNA helicase	K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4] 
E        PK28_03125 DNA polymerase I	K02335 polA; DNA polymerase I [EC:2.7.7.7] 
E        PK28_09550 DNA ligase	K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2] 
D      TCR (transcription coupled repair) factors
E        DNA-directed RNA polymerase complex (RNAP)
F          PK28_15655 rpoB; DNA-directed RNA polymerase subunit beta	K03043 rpoB; DNA-directed RNA polymerase subunit beta [EC:2.7.7.6] 
F          PK28_15650 DNA-directed RNA polymerase subunit beta'	K03046 rpoC; DNA-directed RNA polymerase subunit beta' [EC:2.7.7.6] 
F          PK28_15480 DNA-directed RNA polymerase subunit alpha	K03040 rpoA; DNA-directed RNA polymerase subunit alpha [EC:2.7.7.6] 
E        TRCF (transcription-repair coupling factor)
F          PK28_16385 transcription-repair coupling factor	K03723 mfd; transcription-repair coupling factor (superfamily II helicase) [EC:5.6.2.4] 
C    MMR (mismatch excision repair)
D      Mismatch and loop recognition factors
E        PK28_16320 DNA mismatch repair protein MutS	K03555 mutS; DNA mismatch repair protein MutS 
E        PK28_11385 DNA mismatch repair protein MutS	K07456 mutS2; DNA mismatch repair protein MutS2 
D      Molecular matchmaker
E        PK28_05900 DNA mismatch repair protein MutL	K03572 mutL; DNA mismatch repair protein MutL 
D      Strand discrimination factor
D      DNA exonucleases
D      DNA polymerase III holoenzyme
E        PK28_14520 DNA polymerase III subunit alpha	K02337 dnaE; DNA polymerase III subunit alpha [EC:2.7.7.7] 
E        PK28_08320 DNA polymerase III subunit beta	K02338 dnaN; DNA polymerase III subunit beta [EC:2.7.7.7] 
E        PK28_09995 DNA polymerase III subunit delta	K02340 holA; DNA polymerase III subunit delta [EC:2.7.7.7] 
E        PK28_14885 DNA polymerase III subunit delta	K02341 holB; DNA polymerase III subunit delta' [EC:2.7.7.7] 
E        PK28_09870 DNA polymerase III subunit epsilon	K02342 dnaQ; DNA polymerase III subunit epsilon [EC:2.7.7.7] 
E        PK28_04935 DNA polymerase III subunit gamma/tau	K02343 dnaX; DNA polymerase III subunit gamma/tau [EC:2.7.7.7] 
D      DNA ligase
E        PK28_09550 DNA ligase	K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2] 
D      Other MMR factors
E        PK28_17610 helicase	K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4] 
E        PK28_08805 ATP-dependent DNA helicase	K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4] 
E        PK28_11605 single-stranded DNA-binding protein	K03111 ssb; single-strand DNA-binding protein 
E        PK28_03875 single-stranded DNA-binding protein	K03111 ssb; single-strand DNA-binding protein 
E        PK28_10950 hypothetical protein	K03111 ssb; single-strand DNA-binding protein 
B  DSBR (double strand breaks repair)
C    HR (homologous recombination)
D      RecBC pathway proteins
E        PK28_16250 ATP-dependent DNA helicase RuvA	K03550 ruvA; holliday junction DNA helicase RuvA 
E        PK28_15025 ATP-dependent DNA helicase RuvB	K03551 ruvB; holliday junction DNA helicase RuvB [EC:5.6.2.4] 
E        PK28_07795 crossover junction endodeoxyribonuclease RuvC	K01159 ruvC; crossover junction endodeoxyribonuclease RuvC [EC:3.1.21.10] 
E        PK28_13905 primosomal protein N'	K04066 priA; primosomal protein N' (replication factor Y) (superfamily II helicase) [EC:5.6.2.4] 
E        PK28_06640 hypothetical protein	K03546 sbcC; DNA repair protein SbcC/Rad50 
E        PK28_06670 nuclease SbcCD subunit D	K03547 sbcD; DNA repair protein SbcD/Mre11 
D      RecFOR pathway proteins
E        PK28_01675 DNA repair protein RadA	K04485 radA; DNA repair protein RadA/Sms 
E        PK28_01940 DNA recombination protein RecF	K03629 recF; DNA replication and repair protein RecF 
E        PK28_03865 ATP-dependent DNA helicase RecG	K03655 recG; ATP-dependent DNA helicase RecG [EC:5.6.2.4] 
E        PK28_02000 recombinase RecJ	K07462 recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-] 
E        PK28_04395 hypothetical protein	K03584 recO; DNA repair protein RecO (recombination protein O) 
E        PK28_06465 recombinase RecR	K06187 recR; recombination protein RecR 
E        PK28_05955 DNA repair protein	K03631 recN; DNA repair protein RecN (Recombination protein N) 
E        PK28_16250 ATP-dependent DNA helicase RuvA	K03550 ruvA; holliday junction DNA helicase RuvA 
E        PK28_15025 ATP-dependent DNA helicase RuvB	K03551 ruvB; holliday junction DNA helicase RuvB [EC:5.6.2.4] 
E        PK28_07795 crossover junction endodeoxyribonuclease RuvC	K01159 ruvC; crossover junction endodeoxyribonuclease RuvC [EC:3.1.21.10] 
D      AddAB pathway proteins
E        PK28_11040 hypothetical protein	K16898 addA; ATP-dependent helicase/nuclease subunit A [EC:5.6.2.4 3.1.-.-] 
E        PK28_11050 hypothetical protein	K16899 addB; ATP-dependent helicase/nuclease subunit B [EC:5.6.2.4 3.1.-.-] 
D      Other HR factor
D      Archaeal homologous recombinant proteins
E        PK28_06640 hypothetical protein	K03546 sbcC; DNA repair protein SbcC/Rad50 
E        PK28_06670 nuclease SbcCD subunit D	K03547 sbcD; DNA repair protein SbcD/Mre11 
C    NHEJ (non-homologous end-joining)
D      Two-component NHEJ DNA repair complex
D      SHIIR (short-homology-independent illegitimate recombination)
E        Facilitator
F          PK28_10195 DNA gyrase subunit A	K02469 gyrA; DNA gyrase subunit A [EC:5.6.2.2] 
F          PK28_08705 gyrB; DNA gyrase subunit B	K02470 gyrB; DNA gyrase subunit B [EC:5.6.2.2] 
F          PK28_09845 DNA topoisomerase I	K03168 topA; DNA topoisomerase I [EC:5.6.2.1] 
F          PK28_08745 DNA topoisomerase I	K03168 topA; DNA topoisomerase I [EC:5.6.2.1] 
E        Supressor
F          PK28_03885 DNA-binding protein	K03530 hupB; DNA-binding protein HU-beta 
D      SHDIR (short-homology-dependent illegitimate recombination)
E        RecET pathway
F          PK28_02000 recombinase RecJ	K07462 recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-] 
F          PK28_04395 hypothetical protein	K03584 recO; DNA repair protein RecO (recombination protein O) 
F          PK28_06465 recombinase RecR	K06187 recR; recombination protein RecR 
F          PK28_09550 DNA ligase	K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2] 
E        Facilitator
E        Supressor
F          PK28_07330 ATP-dependent DNA helicase RecQ	K03654 recQ; ATP-dependent DNA helicase RecQ [EC:5.6.2.4] 
F          PK28_14725 ATP-dependent DNA helicase RecQ	K03654 recQ; ATP-dependent DNA helicase RecQ [EC:5.6.2.4] 
F          PK28_02750 excinuclease ABC subunit A	K03701 uvrA; excinuclease ABC subunit A 
F          PK28_03975 excinuclease ABC subunit A	K03701 uvrA; excinuclease ABC subunit A 
F          PK28_11840 excinuclease ABC subunit A	K03701 uvrA; excinuclease ABC subunit A 
F          PK28_15890 excinuclease ABC subunit B	K03702 uvrB; excinuclease ABC subunit B 
B  TLS (translesion DNA synthesis) factors
C    Y-family DNA polymerases
D      PK28_11145 DNA repair protein	K02346 dinB; DNA polymerase IV [EC:2.7.7.7] 
D      PK28_17335 hypothetical protein	K03502 umuC; DNA polymerase V 
D      PK28_07100 hypothetical protein	K03502 umuC; DNA polymerase V 
D      PK28_18045 umuDC operon-like protein	K03503 umuD; DNA polymerase V [EC:3.4.21.-] 
D      PK28_07095 hypothetical protein	K03503 umuD; DNA polymerase V [EC:3.4.21.-] 
D      PK28_17340 umuDC operon-like protein	K03503 umuD; DNA polymerase V [EC:3.4.21.-] 
C    Other SOS response factors
D      PK28_05955 DNA repair protein	K03631 recN; DNA repair protein RecN (Recombination protein N) 
D      PK28_11605 single-stranded DNA-binding protein	K03111 ssb; single-strand DNA-binding protein 
D      PK28_03875 single-stranded DNA-binding protein	K03111 ssb; single-strand DNA-binding protein 
D      PK28_10950 hypothetical protein	K03111 ssb; single-strand DNA-binding protein 
D      PK28_03570 RecX family transcriptional regulator	K03565 recX; regulatory protein 
B  Other factors with a suspected DNA repair function
C    DNA polymerase
D      PK28_14450 DNA polymerase IV	K02347 polX; DNA polymerase (family X) 
C    DNA helicases
C    Modulation of nucleotide pools
D      PK28_12680 hypothetical protein	K23258 mutT1; 8-oxo-(d)GTP phosphatase [EC:3.6.1.69] 
D      PK28_16195 deoxyuridine 5'-triphosphate nucleotidohydrolase	K01520 dut; dUTP diphosphatase [EC:3.6.1.23] 
D      PK28_01135 ribonucleoside-diphosphate reductase	K00525 E1.17.4.1A; ribonucleoside-diphosphate reductase alpha chain [EC:1.17.4.1] 
D      PK28_01125 ribonucleoside-diphosphate reductase	K00526 E1.17.4.1B; ribonucleoside-diphosphate reductase beta chain [EC:1.17.4.1] 
C    Others
D      PK28_04415 exopolyphosphatase	K06881 nrnA; bifunctional oligoribonuclease and PAP phosphatase NrnA [EC:3.1.3.7 3.1.13.3] 
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#Last updated: March 29, 2024