+E Replication protein KO
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DNA Replication Proteins - Kazachstania africana
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AEukaryotic type
B DNA Replication Initiation Factors
C pre-RC (pre-replication complex)
D KAFR_0I00380 KAFR0I00380; hypothetical protein K02603 ORC1; origin recognition complex subunit 1
D KAFR_0E04180 KAFR0E04180; hypothetical protein K02603 ORC1; origin recognition complex subunit 1
D KAFR_0C00440 KAFR0C00440; hypothetical protein K02604 ORC2; origin recognition complex subunit 2
D KAFR_0C06380 KAFR0C06380; hypothetical protein K02605 ORC3; origin recognition complex subunit 3
D KAFR_0B00510 KAFR0B00510; hypothetical protein K02606 ORC4; origin recognition complex subunit 4
D KAFR_0F03460 KAFR0F03460; hypothetical protein K02607 ORC5; origin recognition complex subunit 5
D KAFR_0F00710 KAFR0F00710; hypothetical protein K02608 ORC6; origin recognition complex subunit 6
D KAFR_0F01580 KAFR0F01580; hypothetical protein K02213 CDC6; cell division control protein 6
D KAFR_0C02770 KAFR0C02770; hypothetical protein K02540 MCM2; DNA replication licensing factor MCM2 [EC:5.6.2.3]
D KAFR_0E00550 KAFR0E00550; hypothetical protein K02541 MCM3; DNA replication licensing factor MCM3 [EC:5.6.2.3]
D KAFR_0C03110 KAFR0C03110; hypothetical protein K02212 MCM4; DNA replication licensing factor MCM4 [EC:5.6.2.3]
D KAFR_0A04980 KAFR0A04980; hypothetical protein K02209 MCM5; DNA replication licensing factor MCM5 [EC:5.6.2.3]
D KAFR_0D01430 KAFR0D01430; hypothetical protein K02542 MCM6; DNA replication licensing factor MCM6 [EC:5.6.2.3]
D KAFR_0E03140 KAFR0E03140; hypothetical protein K02210 MCM7; DNA replication licensing factor MCM7 [EC:5.6.2.3]
C CDK (cyclin dependent kinase)
C DDK (Dbf-4 dependent kinase)
D KAFR_0F02310 KAFR0F02310; hypothetical protein K02214 CDC7; cell division control protein 7 [EC:2.7.11.1]
D KAFR_0C00330 KAFR0C00330; hypothetical protein K02309 DBF4; regulatory subunit for Cdc7p protein kinase
D KAFR_0H01280 KAFR0H01280; hypothetical protein K02309 DBF4; regulatory subunit for Cdc7p protein kinase
C GINS complex
D KAFR_0E01080 KAFR0E01080; hypothetical protein K10732 GINS1; GINS complex subunit 1
D KAFR_0A01630 KAFR0A01630; hypothetical protein K10733 GINS2; GINS complex subunit 2
D KAFR_0A08670 KAFR0A08670; hypothetical protein K10734 GINS3; GINS complex subunit 3
D KAFR_0G01270 KAFR0G01270; hypothetical protein K10735 GINS4; GINS complex subunit 4
C Other initiation factors
D KAFR_0A01470 KAFR0A01470; hypothetical protein K03507 DPB11; DNA replication regulator DPB11
D KAFR_0D03140 KAFR0D03140; hypothetical protein K10729 SLD2; DNA replication regulator SLD2
D KAFR_0A04510 KAFR0A04510; hypothetical protein K10731 SLD3; DNA replication regulator SLD3
D KAFR_0B02890 KAFR0B02890; hypothetical protein K06628 CDC45; cell division control protein 45
D KAFR_0D02210 KAFR0D02210; hypothetical protein K10736 MCM10; minichromosome maintenance protein 10
B DNA Replication Elongation Factors
C DNA polymerase alpha / primase complex
D KAFR_0D01990 KAFR0D01990; hypothetical protein K02320 POLA1; DNA polymerase alpha subunit A [EC:2.7.7.7]
D KAFR_0H01120 KAFR0H01120; hypothetical protein K02321 POLA2; DNA polymerase alpha subunit B
D KAFR_0K01020 KAFR0K01020; hypothetical protein K02684 PRI1; DNA primase small subunit [EC:2.7.7.102]
D KAFR_0I01750 KAFR0I01750; hypothetical protein K02685 PRI2; DNA primase large subunit
C DNA polymerase epsilon complex
D KAFR_0D03890 KAFR0D03890; hypothetical protein K02324 POLE; DNA polymerase epsilon subunit 1 [EC:2.7.7.7]
D KAFR_0B00390 KAFR0B00390; hypothetical protein K02325 POLE2; DNA polymerase epsilon subunit 2 [EC:2.7.7.7]
D KAFR_0B05420 KAFR0B05420; hypothetical protein K02326 POLE3; DNA polymerase epsilon subunit 3 [EC:2.7.7.7]
D KAFR_0A01690 KAFR0A01690; hypothetical protein K03506 POLE4; DNA polymerase epsilon subunit 4 [EC:2.7.7.7]
D KAFR_0A03690 KAFR0A03690; hypothetical protein K03506 POLE4; DNA polymerase epsilon subunit 4 [EC:2.7.7.7]
C DNA polymerase delta complex
D KAFR_0K02460 KAFR0K02460; hypothetical protein K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
D KAFR_0J00610 KAFR0J00610; hypothetical protein K02328 POLD2; DNA polymerase delta subunit 2
D KAFR_0F01290 KAFR0F01290; hypothetical protein K03504 POLD3; DNA polymerase delta subunit 3
C DNA polymerase gamma complex (mitochondrial)
D KAFR_0E02360 KAFR0E02360; hypothetical protein K02332 POLG; DNA polymerase gamma 1 [EC:2.7.7.7]
C RPA (replication protein A)
D KAFR_0A06470 KAFR0A06470; hypothetical protein K07466 RFA1; replication factor A1
D KAFR_0C01760 KAFR0C01760; hypothetical protein K10739 RFA2; replication factor A2
C RFC (replication factor C)
D KAFR_0G01910 KAFR0G01910; hypothetical protein K10754 RFC1; replication factor C subunit 1
D KAFR_0E00300 KAFR0E00300; hypothetical protein K10755 RFC2_4; replication factor C subunit 2/4
D KAFR_0C01380 KAFR0C01380; hypothetical protein K10755 RFC2_4; replication factor C subunit 2/4
D KAFR_0H01090 KAFR0H01090; hypothetical protein K10756 RFC3_5; replication factor C subunit 3/5
D KAFR_0A08290 KAFR0A08290; hypothetical protein K10756 RFC3_5; replication factor C subunit 3/5
C RNase H
D KAFR_0D01440 KAFR0D01440; hypothetical protein K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
D KAFR_0J00850 KAFR0J00850; hypothetical protein K10743 RNASEH2A; ribonuclease H2 subunit A [EC:3.1.26.4]
C Other elongation factors
D KAFR_0G01610 KAFR0G01610; hypothetical protein K04802 PCNA; proliferating cell nuclear antigen
D KAFR_0E02220 KAFR0E02220; hypothetical protein K10742 DNA2; DNA replication ATP-dependent helicase/nuclease Dna2 [EC:5.6.2.3 3.1.-.-]
D KAFR_0C03880 KAFR0C03880; hypothetical protein K19783 HCS1; DNA polymerase alpha-associated DNA helicase A [EC:5.6.2.3]
D KAFR_0A00640 KAFR0A00640; hypothetical protein K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
D KAFR_0C05950 KAFR0C05950; hypothetical protein K10746 EXO1; exonuclease 1 [EC:3.1.-.-]
D KAFR_0B00830 KAFR0B00830; hypothetical protein K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
B DNA Replication Termination Factors
C DNA methylation enzymes
C Prevention of re-replication factors
C Telomere proteins
D Shelterin complex
D TERB1-TERB2-MAJIN complex
D CST complex (animals)
D CST complex (yeast)
E KAFR_0F00320 KAFR0F00320; hypothetical protein K11115 CDC13; cell division control protein 13
E KAFR_0A02540 KAFR0A02540; hypothetical protein K11117 STN1; protein STN1
E KAFR_0C06340 KAFR0C06340; hypothetical protein K11116 TEN1; telomere length regulation protein
D RIF proteins
E KAFR_0C04300 KAFR0C04300; hypothetical protein K11118 RIF1; RAP1-interacting factor 1
D SIR proteins
E KAFR_0C05870 KAFR0C05870; hypothetical protein K11121 SIR2; NAD-dependent protein deacetylase SIR2 [EC:2.3.1.286]
E KAFR_0B01640 KAFR0B01640; hypothetical protein K11121 SIR2; NAD-dependent protein deacetylase SIR2 [EC:2.3.1.286]
E KAFR_0C01100 KAFR0C01100; hypothetical protein K11121 SIR2; NAD-dependent protein deacetylase SIR2 [EC:2.3.1.286]
E KAFR_0B06160 KAFR0B06160; hypothetical protein K11121 SIR2; NAD-dependent protein deacetylase SIR2 [EC:2.3.1.286]
E KAFR_0F02130 KAFR0F02130; hypothetical protein K11121 SIR2; NAD-dependent protein deacetylase SIR2 [EC:2.3.1.286]
E KAFR_0E02650 KAFR0E02650; hypothetical protein K11123 SIR4; regulatory protein SIR4
D KAFR_0A07860 KAFR0A07860; hypothetical protein K09426 RAP1; Myb-like DNA-binding protein RAP1
C Telomerase complex (animals)
D KAFR_0A06610 KAFR0A06610; hypothetical protein K11126 TERT; telomerase reverse transcriptase [EC:2.7.7.49]
D Dyskerin complex
E KAFR_0D04870 KAFR0D04870; hypothetical protein K11128 GAR1; H/ACA ribonucleoprotein complex subunit 1
E KAFR_0E02800 KAFR0E02800; hypothetical protein K11129 NHP2; H/ACA ribonucleoprotein complex subunit 2
E KAFR_0C01840 KAFR0C01840; hypothetical protein K11130 NOP10; H/ACA ribonucleoprotein complex subunit 3
E KAFR_0I02150 KAFR0I02150; hypothetical protein K11131 DKC1; H/ACA ribonucleoprotein complex subunit 4 [EC:5.4.99.-]
C Telomerase complex (fungi)
D KAFR_0H01820 KAFR0H01820; hypothetical protein K11132 EST1; telomere elongation protein [EC:2.7.7.-]
D KAFR_0B06260 KAFR0B06260; hypothetical protein K11132 EST1; telomere elongation protein [EC:2.7.7.-]
D KAFR_0A06610 KAFR0A06610; hypothetical protein K11126 TERT; telomerase reverse transcriptase [EC:2.7.7.49]
D KAFR_0L00480 KAFR0L00480; hypothetical protein K11133 EST3; telomere replication protein
D Sm core complex
E KAFR_0I02400 KAFR0I02400; hypothetical protein K11086 SNRPB; small nuclear ribonucleoprotein B and B'
E KAFR_0G01530 KAFR0G01530; hypothetical protein K11087 SNRPD1; small nuclear ribonucleoprotein D1
E KAFR_0A04970 KAFR0A04970; hypothetical protein K11096 SNRPD2; small nuclear ribonucleoprotein D2
E KAFR_0H02100 KAFR0H02100; hypothetical protein K11088 SNRPD3; small nuclear ribonucleoprotein D3
E KAFR_0C05270 KAFR0C05270; hypothetical protein K11097 SNRPE; small nuclear ribonucleoprotein E
E KAFR_0B00320 KAFR0B00320; hypothetical protein K11098 SNRPF; small nuclear ribonucleoprotein F
E KAFR_0C03370 KAFR0C03370; hypothetical protein K11099 SNRPG; small nuclear ribonucleoprotein G
C ELG1-RFC complex
D KAFR_0E02500 KAFR0E02500; hypothetical protein K11134 ELG1; telomere length regulation protein
D KAFR_0E00300 KAFR0E00300; hypothetical protein K10755 RFC2_4; replication factor C subunit 2/4
D KAFR_0C01380 KAFR0C01380; hypothetical protein K10755 RFC2_4; replication factor C subunit 2/4
D KAFR_0H01090 KAFR0H01090; hypothetical protein K10756 RFC3_5; replication factor C subunit 3/5
D KAFR_0A08290 KAFR0A08290; hypothetical protein K10756 RFC3_5; replication factor C subunit 3/5
C MRN complex
D KAFR_0B03320 KAFR0B03320; hypothetical protein K10865 MRE11; double-strand break repair protein MRE11
D KAFR_0D03760 KAFR0D03760; hypothetical protein K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
C Other termination factors
D KAFR_0L01900 KAFR0L01900; hypothetical protein K04728 ATM; serine-protein kinase ATM [EC:2.7.11.1]
D KAFR_0A07190 KAFR0A07190; hypothetical protein K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
D KAFR_0H01600 KAFR0H01600; hypothetical protein K10848 ERCC4; DNA excision repair protein ERCC-4 [EC:3.1.-.-]
D KAFR_0C06490 KAFR0C06490; hypothetical protein K11135 PINX1; Pin2-interacting protein X1
D KAFR_0K01620 KAFR0K01620; hypothetical protein K11137 TELO2; telomere length regulation protein
D KAFR_0E01820 KAFR0E01820; hypothetical protein K15255 PIF1; ATP-dependent DNA helicase PIF1 [EC:5.6.2.3]
D KAFR_0I00420 KAFR0I00420; hypothetical protein K15255 PIF1; ATP-dependent DNA helicase PIF1 [EC:5.6.2.3]
D KAFR_0A07590 KAFR0A07590; hypothetical protein K23314 WRAP53; telomerase Cajal body protein 1
D KAFR_0A02990 KAFR0A02990; hypothetical protein K25186 RTF2; replication termination factor 2
D KAFR_0H02660 KAFR0H02660; hypothetical protein K22485 TBF1; protein TBF1
B DNA Topoisomerases
C KAFR_0G02700 KAFR0G02700; hypothetical protein K03163 TOP1; DNA topoisomerase I [EC:5.6.2.1]
C KAFR_0J01230 KAFR0J01230; hypothetical protein K03164 TOP2; DNA topoisomerase II [EC:5.6.2.2]
C KAFR_0H01830 KAFR0H01830; hypothetical protein K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
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AProkaryotic type
B DNA Replication Initiation Factors
C Initiation factors (bacterial)
C Initiation factors (archaeal)
B DNA Replication Elongation Factors
C Elongation factors (bacterial)
D DNA polymerase III holoenzyme
D RNase H
E KAFR_0D01440 KAFR0D01440; hypothetical protein K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
D Other elongation factors
C Elongation factors (archaeal)
D B-family DNA polymerases
D D-family DNA polymerases
D RNase H
E KAFR_0D01440 KAFR0D01440; hypothetical protein K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
D RFC (replication factor C)
D Other elongation factors
E KAFR_0E02220 KAFR0E02220; hypothetical protein K10742 DNA2; DNA replication ATP-dependent helicase/nuclease Dna2 [EC:5.6.2.3 3.1.-.-]
E KAFR_0A00640 KAFR0A00640; hypothetical protein K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
E KAFR_0B00830 KAFR0B00830; hypothetical protein K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
B DNA Replication Termination Factors
C Terminus site-binding protein
C DNA methylation enzymes
C Prevention of re-replication factors
B DNA Topoisomerases
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: November 2, 2022