+C Two-component system KO #

  Two-Component System - Klebsiella sp. MPUS7

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AOmpR family B PhoR-PhoB (phosphate starvation response) C GUC22_21050 phoR; (GenBank) phosphate regulon sensor histidine kinase PhoR K07636 phoR; two-component system, OmpR family, phosphate regulon sensor histidine kinase PhoR [EC:2.7.13.3] C GUC22_21055 phoB; (GenBank) phosphate response regulator transcription factor PhoB K07657 phoB; two-component system, OmpR family, phosphate regulon response regulator PhoB B SenX3-RegX3 (phosphate starvation response) B PhoQ-PhoP (magnesium transport) C GUC22_16010 phoQ; (GenBank) two-component system sensor histidine kinase PhoQ K07637 phoQ; two-component system, OmpR family, sensor histidine kinase PhoQ [EC:2.7.13.3] C GUC22_16005 phoP; (GenBank) two-component system response regulator PhoP K07660 phoP; two-component system, OmpR family, response regulator PhoP B EnvZ-OmpR (osmotic stress response) C GUC22_01290 envZ; (GenBank) two-component system sensor histidine kinase EnvZ K07638 envZ; two-component system, OmpR family, osmolarity sensor histidine kinase EnvZ [EC:2.7.13.3] C GUC22_01295 ompR; (GenBank) two-component system response regulator OmpR K07659 ompR; two-component system, OmpR family, phosphate regulon response regulator OmpR B RstB-RstA C GUC22_11670 rstB; (GenBank) two-component system sensor histidine kinase RstB K07639 rstB; two-component system, OmpR family, sensor histidine kinase RstB [EC:2.7.13.3] C GUC22_11680 rstA; (GenBank) two-component system response regulator RstA K07661 rstA; two-component system, OmpR family, response regulator RstA B CpxA-CpxR (envelope stress response) C GUC22_26495 cpxA; (GenBank) envelope stress sensor histidine kinase CpxA K07640 cpxA; two-component system, OmpR family, sensor histidine kinase CpxA [EC:2.7.13.3] C GUC22_26490 cpxR; (GenBank) envelope stress response regulator transcription factor CpxR K07662 cpxR; two-component system, OmpR family, response regulator CpxR B CssS-CssR (secretion stress response) B CreC-CreB (phosphate regulation) C GUC22_23100 creC; (GenBank) two-component system sensor histidine kinase CreC K07641 creC; two-component system, OmpR family, sensor histidine kinase CreC [EC:2.7.13.3] C GUC22_23105 creB; (GenBank) two-component system response regulator CreB K07663 creB; two-component system, OmpR family, catabolic regulation response regulator CreB B BaeS-BaeR (envelope stress response) C GUC22_08335 baeS; (GenBank) two-component system sensor histidine kinase BaeS K07642 baeS; two-component system, OmpR family, sensor histidine kinase BaeS [EC:2.7.13.3] C GUC22_08330 baeR; (GenBank) two-component system response regulator BaeR K07664 baeR; two-component system, OmpR family, response regulator BaeR B BasS-BasR (antimicrobial peptide resistance) C GUC22_18480 pmrB; (GenBank) two-component system sensor histidine kinase PmrB K07643 basS; two-component system, OmpR family, sensor histidine kinase BasS [EC:2.7.13.3] C GUC22_18475 pmrA; (GenBank) two-component system response regulator PmrA K07771 basR; two-component system, OmpR family, response regulator BasR B CusS-CusR (copper tolerance) C GUC22_09030 heavy metal sensor histidine kinase K07644 cusS; two-component system, OmpR family, heavy metal sensor histidine kinase CusS [EC:2.7.13.3] C GUC22_09025 heavy metal response regulator transcription factor K07665 cusR; two-component system, OmpR family, copper resistance phosphate regulon response regulator CusR B QseC-QseB (quorum sensing) C GUC22_03525 qseC; (GenBank) two-component system sensor histidine kinase QseC K07645 qseC; two-component system, OmpR family, sensor histidine kinase QseC [EC:2.7.13.3] C GUC22_03530 qseB; (GenBank) two-component system response regulator QseB K07666 qseB; two-component system, OmpR family, response regulator QseB B KdpD-KdpE (potassium transport) C GUC22_18970 kdbD; (GenBank) two-component system sensor histidine kinase KdbD K07646 kdpD; two-component system, OmpR family, sensor histidine kinase KdpD [EC:2.7.13.3] C GUC22_18975 kdpE; (GenBank) two-component system response regulator KdpE K07667 kdpE; two-component system, OmpR family, KDP operon response regulator KdpE B TorS-TorR (TMAO respiration) B ArcB-ArcA (anoxic redox control) C GUC22_02600 arcB; (GenBank) aerobic respiration two-component sensor histidine kinase ArcB K07648 arcB; two-component system, OmpR family, aerobic respiration control sensor histidine kinase ArcB [EC:2.7.13.3] C GUC22_23090 arcA; (GenBank) two-component system response regulator ArcA K07773 arcA; two-component system, OmpR family, aerobic respiration control protein ArcA B TctE-TctD (tricarboxylic acid transport) C GUC22_07595 HAMP domain-containing protein K07649 tctE; two-component system, OmpR family, sensor histidine kinase TctE [EC:2.7.13.3] C GUC22_07590 tctD; (GenBank) transcriptional regulator TctD K07774 tctD; two-component system, OmpR family, response regulator TctD B ResE-ResD (aerobic and anaerobic respiration) B VicK-VicR (cell wall metabolism) B MprB-MprA (maintenance of persistent infection) B MtrB-MtrA (osmotic stress response) B PrrB-PrrA (intracellular multiplication) B TrcS-TrcR B NrsS-NrsR (nickel tolerance) B ManS-ManR (manganese homeostasis) B NblS-NblR (photosynthesis) B SasA-RpaAB (circadian timing mediating) B SaeS-SaeR (staphylococcal virulence regulation) B BceS-BceR (bacitracin transport) B BraS-BraR (bacitracin transport) B GraS-GraR (cationic antimicrobial peptide transport) B YxdK-YxdJ (antimicrobial peptide response) B ChvG-ChvI (acidity sensing) B CiaH-CiaR B ParS-ParR (polymyxin-adaptive resistance) B AdeS-AdeR B VanS-VanR (VanB type vancomycin resistance) B VanS-VanR (VanE type vancomycin resistance) B VanS-VanR (actinomycete type vancomycin resistance) B ArlS-ArlR (virulence regulation) B Ihk-Irr (virulence regulation) B PfeS-PfeR (enterobactin-dependent iron acquisition) B NisK-NisR (lantibiotic biosynthesis) B Unclassified # ANarL family B NarX-NarL (nitrate respiration) C GUC22_10535 narX; (GenBank) nitrate/nitrite two-component system sensor histidine kinase NarX K07673 narX; two-component system, NarL family, nitrate/nitrite sensor histidine kinase NarX [EC:2.7.13.3] C GUC22_10530 narL; (GenBank) two-component system response regulator NarL K07684 narL; two-component system, NarL family, nitrate/nitrite response regulator NarL B NarQ-NarP (nitrate respiration) B UhpB-UhpA (hexose phosphates uptake) C GUC22_00190 uhpB; (GenBank) signal transduction histidine-protein kinase/phosphatase UhpB K07675 uhpB; two-component system, NarL family, sensor histidine kinase UhpB [EC:2.7.13.3] C GUC22_00185 uhpA; (GenBank) transcriptional regulator UhpA K07686 uhpA; two-component system, NarL family, uhpT operon response regulator UhpA B FusK-FusR (virulence regulation) C GUC22_21235 MASE1 sensor histidine kinase K20263 fusK; two-component system, NarL family, sensor histidine kinase FusK [EC:2.7.13.3] C GUC22_21230 response regulator K20264 fusR; two-component system, NarL family, response regulator FusR B RcsC-RcsD-RcsB (capsule synthesis) C GUC22_07695 rcsC; (GenBank) two-component system sensor histidine kinase RcsC K07677 rcsC; two-component system, NarL family, capsular synthesis sensor histidine kinase RcsC [EC:2.7.13.3] C GUC22_07705 rcsD; (GenBank) phosphotransferase RcsD K07676 rcsD; two-component system, NarL family, sensor histidine kinase RcsD [EC:2.7.13.3] C GUC22_07700 rcsB; (GenBank) transcriptional regulator RcsB K07687 rcsB; two-component system, NarL family, captular synthesis response regulator RcsB B BarA-UvrY (central carbon metabolism) C GUC22_05015 barA; (GenBank) two-component sensor histidine kinase BarA K07678 barA; two-component system, NarL family, sensor histidine kinase BarA [EC:2.7.13.3] C GUC22_09555 uvrY; (GenBank) UvrY/SirA/GacA family response regulator transcription factor K07689 uvrY; two-component system, NarL family, invasion response regulator UvrY B ComP-ComA (competence) B EvgS-EvgA (acid and drug tolerance) B DegS-DegU (multicellular behavior control) B DesK-DesR (membrane lipid fluidity regulation) B VraS-VraR (cell-wall peptidoglycan synthesis) B LiaS-LiaR (cell wall stress response) B DevS-DevR (redox response) B NreB-NreC (dissimilatory nitrate/nitrite reduction) B YdfH-YdfI B SalK-SalR B PprA–PprB (biofilm formation) B Unclassified # ASpo family B KinABCDE-Spo0FA (sporulation control) # ACitB family B CitA-CitB (citrate fermentation) C GUC22_17050 GHKL domain-containing protein K07700 dpiB; two-component system, CitB family, cit operon sensor histidine kinase CitA [EC:2.7.13.3] C GUC22_22760 GHKL domain-containing protein K07700 dpiB; two-component system, CitB family, cit operon sensor histidine kinase CitA [EC:2.7.13.3] C GUC22_22900 GHKL domain-containing protein K07700 dpiB; two-component system, CitB family, cit operon sensor histidine kinase CitA [EC:2.7.13.3] C GUC22_17055 response regulator K07702 dpiA; two-component system, CitB family, response regulator CitB C GUC22_22765 response regulator K07702 dpiA; two-component system, CitB family, response regulator CitB C GUC22_22905 response regulator K07702 dpiA; two-component system, CitB family, response regulator CitB B CitS-CitT (magnesium-citrate transport) B DcuS-DcuR (C4-dicarboxylate metabolism) C GUC22_11825 dcuS; (GenBank) two-component system sensor histidine kinase DcuS K07701 dcuS; two-component system, CitB family, sensor histidine kinase DcuS [EC:2.7.13.3] C GUC22_11820 dcuR; (GenBank) two-component system response regulator DcuR K07703 dcuR; two-component system, CitB family, response regulator DcuR B DctS-DctR (C4-dicarboxylate transport) B MalK-MalR (malate transport) B Unclassified # ALytTR family B LysS-LysR B AlgZ-AlgR (alginate production) B NatK-NatR (sodium extrusion) B AgrC-AgrA (exoprotein synthesis) B AgrC2-AgrA2 (virulence regulation) B ComD-ComE (competence) B BtsS-BtsR (pyruvate reutilization) C GUC22_08130 sensor histidine kinase K27882 btsS; two-component system, LytTR family, low-concentration pyruvate sensor kinase [EC:2.7.13.3] C GUC22_08135 yehT; (GenBank) two-component system response regulator BtsR K27883 btsR; two-component system, LytTR family, low-concentration pyruvate response regulator B PyrS-PyrR (pyruvate reutilization) C GUC22_07120 sensor histidine kinase K27884 pyrS; two-component system, LytTR family, high-concentration pyruvate sensor kinase [EC:2.7.13.3] C GUC22_07115 response regulator K27885 pyrR; two-component system, LytTR family, high-concentration pyruvate response regulator B Unclassified # ANtrC family B GlnL-GlnG (nitrogen regulation) C GUC22_26885 nitrogen regulation protein NR(II) K07708 glnL; two-component system, NtrC family, nitrogen regulation sensor histidine kinase GlnL [EC:2.7.13.3] C GUC22_26890 nitrogen regulation protein NR(I) K07712 glnG; two-component system, NtrC family, nitrogen regulation response regulator GlnG B NtrY-NtrX (nitrogen regulation) B HydH-HydG (metal tolerance) C GUC22_25630 zraS; (GenBank) two-component system sensor histidine kinase ZraS K07709 zraS; two-component system, NtrC family, sensor histidine kinase HydH [EC:2.7.13.3] C GUC22_25625 zraR; (GenBank) sigma-54-dependent response regulator transcription factor ZraR K07713 zraR; two-component system, NtrC family, response regulator HydG B AtoS-AtoC (cPHB biosynthesis) B PilS-PilR (type 4 fimbriae synthesis) B GlrK-GlrR (amino sugar metabolism) C GUC22_06375 two-component sensor histidine kinase K07711 glrK; two-component system, NtrC family, sensor histidine kinase GlrK [EC:2.7.13.3] C GUC22_06385 glrR; (GenBank) two-component system response regulator GlrR K07715 glrR; two-component system, NtrC family, response regulator GlrR B PgtB-PgtA (phosphoglycerate transport) C GUC22_13055 pgtB; (GenBank) two-component system sensor histidine kinase PgtB K08475 pgtB; two-component system, NtrC family, phosphoglycerate transport system sensor histidine kinase PgtB [EC:2.7.13.3] C GUC22_13060 pgtA; (GenBank) two-component system response regulator PgtA K08476 pgtA; two-component system, NtrC family, phosphoglycerate transport system response regulator PgtA B DctB-DctD (C4-dicarboxylate transport) B KinB-AlgB (alginate production) B HupT-HupR (hydrogenase synthesis regulation) B Unclassified # ACheA family B CheA-CheYBV (chemotaxis) B ChpA-ChpB/PilGH (chemosensory) B PixL-PixGH (positive phototaxis) B WspE-WspRF (chemosensory) B Cph1-Rcp1 (light response) # ACell cycle family B PleC-PleD (cell fate control) B CckA-CtrA/CpdR (cell cycle control) B Hk1-Rrp1 (glycerol uptake and utilization) # ALux family B LuxQN/CqsS-LuxU-LuxO (quorum sensing) # ALuxR family B DctS-DctR (C4-dicarboxylate transport) B TtrS-TtrR (tetrathionate respiration) C GUC22_12900 PhnD/SsuA/transferrin family substrate-binding protein K13040 ttrS; two-component system, LuxR family, sensor histidine kinase TtrS [EC:2.7.13.3] C GUC22_12905 response regulator K13041 ttrR; two-component system, LuxR family, response regulator TtrR B FixL-FixJ (nitrogen fixation) B SsrA-SsrB # AOther families B FlrB-FlrC (polar flagellar synthesis) B AauS-AauR (acidic amino acids utilization) B SLN1-YPD1-SSK1/SKN7 (osmosensing) B RpfC-RpfG (cell-to-cell signaling) B GlnK-GlnL (glutamine utilization) B HspS-HspR (hexose phosphates uptake) B YesM-YesN B CikA B RegB-RegA (redox response) B FitF-FitH (insecticidal toxin regulation) B PhcS-PhcRQ B SagS-HptB-HsbR (swarming activity and biofilm formation) B PdtaS-PdtaR B NasS-NasT B Unclassified C GUC22_10605 rssB; (GenBank) two-component system response regulator RssB K02485 rssB; two-component system, response regulator ! #
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#Last updated: October 8, 2024