+F Repair protein KO
#
DNA Repair and Recombination Proteins - Kluyveromyces marxianus
%
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AEukaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D KLMA_20639 MGT1; methylated-DNA--protein-cysteine methyltransferase K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
D KLMA_80011 PHR1; deoxyribodipyrimidine photo-lyase K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]
C BER (base exicision repair)
D DNA glycosylases
E KLMA_40589 UNG1; uracil-DNA glycosylase K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E KLMA_50174 OGG1; N-glycosylase/DNA lyase K03660 OGG1; N-glycosylase/DNA lyase [EC:3.2.2.- 4.2.99.18]
E KLMA_20363 NTG2; DNA base excision repair N-glycosylase 2 K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
E KLMA_30564 APN1; DNA-(apurinic or apyrimidinic site) lyase 1 K10771 APEX1; AP endonuclease 1 [EC:3.1.11.2]
E KLMA_20038 APN2; DNA-(apurinic or apyrimidinic site) lyase 2 K10772 APEX2; AP endonuclease 2 [EC:3.1.11.2]
D Long Patch-BER factors
E DNA polymerase delta complex
F KLMA_20646 POL3; DNA polymerase delta catalytic subunit K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
F KLMA_30195 POL31; DNA polymerase delta small subunit K02328 POLD2; DNA polymerase delta subunit 2
F KLMA_10716 DNA polymerase delta subunit 3 K03504 POLD3; DNA polymerase delta subunit 3
E DNA polymerase epsilon complex
F KLMA_10117 POL2; DNA polymerase epsilon catalytic subunit A K02324 POLE; DNA polymerase epsilon subunit 1 [EC:2.7.7.7]
F KLMA_20503 DPB2; DNA polymerase epsilon subunit B K02325 POLE2; DNA polymerase epsilon subunit 2 [EC:2.7.7.7]
F KLMA_40151 DPB4; DNA polymerase epsilon subunit D K02326 POLE3; DNA polymerase epsilon subunit 3 [EC:2.7.7.7]
F KLMA_50078 DPB3; DNA polymerase epsilon subunit C K03506 POLE4; DNA polymerase epsilon subunit 4 [EC:2.7.7.7]
E KLMA_70334 POL30; proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
E KLMA_30565 FEN1; structure-specific endonuclease RAD27 K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
E KLMA_50322 CDC9; DNA ligase 1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
D Short Patch-BER factors
D Other BER factors
E KLMA_20277 TDP1; tyrosyl-DNA phosphodiesterase 1 K10862 TDP1; tyrosyl-DNA phosphodiesterase 1 [EC:3.1.4.-]
E KLMA_30465 HNT3; aprataxin-like protein K10863 APTX; aprataxin [EC:3.6.1.70 3.6.1.71 3.6.1.72]
E KLMA_20655 TPP1; polynucleotide 3'-phosphatase K08075 E3.1.3.32; polynucleotide 3'-phosphatase [EC:3.1.3.32]
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E XPC-HR23B-CETN2 complex
F KLMA_30173 RAD4; DNA repair protein RAD4 K10838 XPC; xeroderma pigmentosum group C-complementing protein
F KLMA_10706 RAD23; UV excision repair protein RAD23 K10839 RAD23; UV excision repair protein RAD23
E Cul4-DDB2 complex
F KLMA_70161 HRT1; RING-box protein HRT1 K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
E NER4 complex
F KLMA_10420 RAD7; DNA repair protein RAD7 K15082 RAD7; DNA repair protein RAD7
F KLMA_80298 RAD16; DNA repair protein RAD16 K15083 RAD16; DNA repair protein RAD16
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase II complex
F KLMA_60512 RPB1; DNA-directed RNA polymerase II subunit RPB1 K03006 RPB1; DNA-directed RNA polymerase II subunit RPB1 [EC:2.7.7.6]
F KLMA_50187 RPB2; DNA-directed RNA polymerase II subunit RPB2 K03010 RPB2; DNA-directed RNA polymerase II subunit RPB2 [EC:2.7.7.6]
F KLMA_50478 RPB3; DNA-directed RNA polymerase II subunit RPB3 K03011 RPB3; DNA-directed RNA polymerase II subunit RPB3
F KLMA_10351 RPB4; DNA-directed RNA polymerase II subunit RPB4 K03012 RPB4; DNA-directed RNA polymerase II subunit RPB4
F KLMA_40224 RPB5; DNA-directed RNA polymerases I K03013 RPABC1; DNA-directed RNA polymerases I, II, and III subunit RPABC1
F KLMA_40475 RPO26; DNA-directed RNA polymerases I K03014 RPABC2; DNA-directed RNA polymerases I, II, and III subunit RPABC2
F KLMA_10300 RPB7; DNA-directed RNA polymerase II subunit RPB7 K03015 RPB7; DNA-directed RNA polymerase II subunit RPB7
F KLMA_20792 RPB8; DNA-directed RNA polymerases I K03016 RPABC3; DNA-directed RNA polymerases I, II, and III subunit RPABC3
F KLMA_10645 RPB9; DNA-directed RNA polymerase II subunit RPB9 K03017 RPB9; DNA-directed RNA polymerase II subunit RPB9
F KLMA_20809 RPB10; DNA-directed RNA polymerases I K03007 RPABC5; DNA-directed RNA polymerases I, II, and III subunit RPABC5
F KLMA_10271 RPB11; DNA-directed RNA polymerase II subunit RPB11 K03008 RPB11; DNA-directed RNA polymerase II subunit RPB11
F KLMA_20755 RPC10; DNA-directed RNA polymerases I K03009 RPABC4; DNA-directed RNA polymerases I, II, and III subunit RPABC4
E Cul4-CSA complex
F KLMA_70161 HRT1; RING-box protein HRT1 K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
E Other TCR factor
F KLMA_10725 RAD26; DNA repair and recombination protein RAD26 K10841 ERCC6; DNA excision repair protein ERCC-6
F KLMA_40252 ELF1; transcription elongation factor 1 K25829 ELOF1; transcription elongation factor 1
D TFIIH complex
E KLMA_70387 SSL2; DNA repair helicase RAD25 K10843 ERCC3; DNA excision repair protein ERCC-3 [EC:5.6.2.4]
E KLMA_30290 RAD3; DNA repair helicase RAD3 K10844 ERCC2; DNA excision repair protein ERCC-2 [EC:5.6.2.3]
E KLMA_30547 TFB1; RNA polymerase II transcription factor B subunit 1 K03141 TFIIH1; transcription initiation factor TFIIH subunit 1
E KLMA_80072 SSL1; suppressor of stem-loop protein 1 K03142 TFIIH2; transcription initiation factor TFIIH subunit 2
E KLMA_80328 TFB4; RNA polymerase II transcription factor B subunit 4 K03143 TFIIH3; transcription initiation factor TFIIH subunit 3
E KLMA_50042 TFB2; RNA polymerase II transcription factor B subunit 2 K03144 TFIIH4; transcription initiation factor TFIIH subunit 4
E KLMA_60012 KIN28; serine/threonine-protein kinase KIN28 K02202 CDK7; cyclin-dependent kinase 7 [EC:2.7.11.22 2.7.11.23]
E KLMA_70141 CCL1; cyclin CCL1 K06634 CCNH; cyclin H
E KLMA_30537 TFB3; RNA polymerase II transcription factor B subunit 3 K10842 MNAT1; CDK-activating kinase assembly factor MAT1
D RPA (replication factor A)
E KLMA_10451 RFA1; replication factor A protein 1 K07466 RFA1; replication factor A1
E KLMA_40398 RFA2; replication factor A protein 2 K10739 RFA2; replication factor A2
D Other NER factors
E KLMA_20422 RAD14; DNA excision repair protein K10847 XPA; DNA-repair protein complementing XP-A cells
E KLMA_20664 RAD10; DNA repair protein RAD10 K10849 ERCC1; DNA excision repair protein ERCC-1
E KLMA_60377 RAD1; DNA repair protein RAD1 K10848 ERCC4; DNA excision repair protein ERCC-4 [EC:3.1.-.-]
E KLMA_10473 RAD2; DNA repair protein RAD2 K10846 ERCC5; DNA excision repair protein ERCC-5
E KLMA_50322 CDC9; DNA ligase 1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
E KLMA_60537 MET18; DNA repair/transcription protein MET18/MMS19 K15075 MET18; DNA repair/transcription protein MET18/MMS19
E KLMA_40036 CUL3; cullin-3 K03869 CUL3; cullin 3
E KLMA_60398 elongin-C K03872 ELOC; elongin-C
E KLMA_50620 ELA1; elongin-A K15077 ELA1; elongin-A
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
E KLMA_30578 MSH2; DNA mismatch repair protein MSH2 K08735 MSH2; DNA mismatch repair protein MSH2
E KLMA_40023 MSH3; DNA mismatch repair protein MSH3 K08736 MSH3; DNA mismatch repair protein MSH3
E KLMA_30293 MSH6; DNA mismatch repair protein MSH6 K08737 MSH6; DNA mismatch repair protein MSH6
D MutL homologs
E KLMA_20675 MLH1; DNA mismatch repair protein MLH1 K08734 MLH1; DNA mismatch repair protein MLH1
E KLMA_30390 PMS1; DNA mismatch repair protein PMS1 K10858 PMS2; DNA mismatch repair protein PMS2
E KLMA_30446 MLH3; DNA mismatch repair protein MLH3 K08739 MLH3; DNA mismatch repair protein MLH3
D DNA polymerase delta complex
E KLMA_20646 POL3; DNA polymerase delta catalytic subunit K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
E KLMA_30195 POL31; DNA polymerase delta small subunit K02328 POLD2; DNA polymerase delta subunit 2
E KLMA_10716 DNA polymerase delta subunit 3 K03504 POLD3; DNA polymerase delta subunit 3
D RPA (replication factor A)
E KLMA_10451 RFA1; replication factor A protein 1 K07466 RFA1; replication factor A1
E KLMA_40398 RFA2; replication factor A protein 2 K10739 RFA2; replication factor A2
D RFC (replication factor C)
E KLMA_20802 replication factor C subunit 1 K10754 RFC1; replication factor C subunit 1
E KLMA_10167 RFC4; replication factor C subunit 4 K10755 RFC2_4; replication factor C subunit 2/4
E KLMA_30044 RFC2; replication factor C subunit 2 K10755 RFC2_4; replication factor C subunit 2/4
E KLMA_70397 RFC3; replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
E KLMA_70341 RFC5; replication factor C subunit 5 K10756 RFC3_5; replication factor C subunit 3/5
D Other MMR factors
E KLMA_70334 POL30; proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
E KLMA_60096 EXO1; exodeoxyribonuclease 1 K10746 EXO1; exonuclease 1 [EC:3.1.-.-]
E KLMA_50322 CDC9; DNA ligase 1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
E KLMA_70244 uncharacterized protein K24755 WDR76; WD repeat-containing protein 76
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D MRN(MRX) complex
E KLMA_10306 MRE11; double-strand break repair protein MRE11 K10865 MRE11; double-strand break repair protein MRE11
E KLMA_10132 RAD50; DNA repair protein RAD50 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
E KLMA_20618 DNA repair protein XRS2 K10868 XRS2; DNA repair protein XRS2
D BRCA1-core complex
D BRCA1-A complex
D BRCA1-B complex
D BRCA1-C complex
E KLMA_10306 MRE11; double-strand break repair protein MRE11 K10865 MRE11; double-strand break repair protein MRE11
E KLMA_10132 RAD50; DNA repair protein RAD50 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
D BRCA complex
E KLMA_80356 RAD51; DNA repair protein RAD51 K04482 RAD51; DNA repair protein RAD51
D RecA family proteins
E KLMA_80356 RAD51; DNA repair protein RAD51 K04482 RAD51; DNA repair protein RAD51
E KLMA_20426 RAD55; p-loop NTPase super family K10957 RAD55; DNA repair protein RAD55
E KLMA_60126 RAD57; DNA repair protein RAD57 K10958 RAD57; DNA repair protein RAD57
D Rad52 family proteins
E KLMA_40568 RAD52; DNA repair and recombination protein RAD52 K10873 RAD52; DNA repair and recombination protein RAD52
E KLMA_70074 RAD59; DNA repair protein RAD59 K10959 RAD59; DNA repair protein RAD59
D Rad54 family proteins
E KLMA_30615 RAD54; DNA repair and recombination protein RAD54 K10875 RAD54L; DNA repair and recombination protein RAD54 and RAD54-like protein [EC:5.6.2.-]
E KLMA_20179 RDH54; DNA repair and recombination protein RDH54 K10877 RAD54B; DNA repair and recombination protein RAD54B [EC:5.6.2.-]
D RecQ family DNA helicases
E KLMA_50331 SGS1; ATP-dependent helicase SGS1 K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
D Bloom's syndrome complex (BTR)
E KLMA_50331 SGS1; ATP-dependent helicase SGS1 K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E KLMA_40206 TOP3; DNA topoisomerase 3 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E KLMA_60379 RMI1; RecQ-mediated genome instability protein 1 K15364 NCE4; RecQ-mediated genome instability protein 1
D RPA (replication factor A)
E KLMA_10451 RFA1; replication factor A protein 1 K07466 RFA1; replication factor A1
E KLMA_40398 RFA2; replication factor A protein 2 K10739 RFA2; replication factor A2
D Protein phosphatase 4
E KLMA_20019 PPH3; serine/threonine-protein phosphatase 4 catalytic subunit K15423 PPP4C; serine/threonine-protein phosphatase 4 catalytic subunit [EC:3.1.3.16]
E KLMA_50586 PSY2; serine/threonine-protein phosphatase 4 regulatory subunit 3 K17491 SMEK; protein phosphatase 4 regulatory subunit 3
D AP-5 complex
D SMC5-SMC6 complex
E KLMA_20350 SMC5; structural maintenance of chromosomes protein 5 K22803 SMC5; structural maintenance of chromosomes protein 5
E KLMA_70076 SMC6; structural maintenance of chromosomes protein 6 K22804 SMC6; structural maintenance of chromosomes protein 6
E KLMA_80079 NSE1; non-structural maintenance of chromosomes element 1 K22817 NSMCE1; non-structural maintenance of chromosomes element 1 [EC:2.3.2.27]
E KLMA_10563 MMS21; E3 SUMO-protein ligase MMS21 K22756 NSMCE2; E3 SUMO-protein ligase NSE2 [EC:2.3.2.-]
E KLMA_20724 non-structural maintenance of chromosome element 3 K22823 NSMCE3; non-structural maintenance of chromosomes element 3
E KLMA_20676 NSE4; non-structural maintenance of chromosome element 4 K22825 NSMCE4; non-structural maintenance of chromosomes element 4
D Other HR factors
E KLMA_20080 EME1; crossover junction endonuclease EME1 K10882 EME1; crossover junction endonuclease EME1 [EC:3.1.22.-]
E KLMA_20581 MUS81; crossover junction endonuclease MUS81 K08991 MUS81; crossover junction endonuclease MUS81 [EC:3.1.22.-]
E KLMA_80402 probable 26S proteasome complex subunit SEM1 K10881 SHFM1; 26 proteasome complex subunit DSS1
E KLMA_50044 MEI5; meiosis protein 5 K10992 SFR1; Swi5-dependent recombination DNA repair protein 1
E KLMA_20273 SLX1; structure-specific endonuclease subunit SLX1 K15078 SLX1; structure-specific endonuclease subunit SLX1 [EC:3.6.1.-]
E KLMA_50494 SLX4; structure-specific endonuclease subunit SLX4 K15079 SLX4; structure-specific endonuclease subunit SLX4
E KLMA_30683 YEN1; uncharacterized protein K15338 GEN1; holliday junction resolvase GEN1/YEN1 [EC:3.1.-.-]
E KLMA_70409 EAF3; chromatin modification-related protein EAF3 K11339 MORF4L1; mortality factor 4-like protein 1
E KLMA_10757 YTA6; probable 26S protease subunit YTA6 K22766 FIGNL1; fidgetin-like protein 1 [EC:5.6.2.-]
E KLMA_20519 protein SAP1 K22766 FIGNL1; fidgetin-like protein 1 [EC:5.6.2.-]
E KLMA_40353 WSS1; DNA damage response protein WSS1 K22685 WSS1; DNA-dependent metalloprotease WSS1 [EC:3.4.24.-]
E KLMA_50375 MPH1; ATP-dependent DNA helicase MPH1 K14635 MPH1; ATP-dependent DNA helicase MPH1 [EC:5.6.2.4]
E KLMA_50115 SAW1; single-strand annealing weakened protein 1 K15080 SAW1; single-strand annealing weakened protein 1
E KLMA_50091 cullin K26124 RTT101; cullin 8
E KLMA_40034 MMS22; methyl methanesulfonate-sensitivity protein 22 K26122 MMS22; E3 ubiquitin-protein ligase substrate receptor MMS22
C NHEJ (non-homologous end-joining)
D DNA-PK complex
E KLMA_10274 KU70; ATP-dependent DNA helicase II subunit 1 K10884 XRCC6; ATP-dependent DNA helicase 2 subunit 1
E KLMA_30100 YKU80; ATP-dependent DNA helicase II subunit 2 K10885 XRCC5; ATP-dependent DNA helicase 2 subunit 2
D MRX complex
E KLMA_10306 MRE11; double-strand break repair protein MRE11 K10865 MRE11; double-strand break repair protein MRE11
E KLMA_10132 RAD50; DNA repair protein RAD50 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
E KLMA_20618 DNA repair protein XRS2 K10868 XRS2; DNA repair protein XRS2
D DNA Ligase 4 complex
E KLMA_80033 LIG4; DNA ligase 4 K10777 LIG4; DNA ligase 4 [EC:6.5.1.1]
D X-family DNA polymerases
E KLMA_10541 POL4; DNA polymerase IV K10981 POL4; DNA polymerase IV [EC:2.7.7.7]
D Other NHEJ factors
E KLMA_30465 HNT3; aprataxin-like protein K10863 APTX; aprataxin [EC:3.6.1.70 3.6.1.71 3.6.1.72]
C FA (Fanconi anemia) pathway
D FA core complex
D FA core complex binding factors
E KLMA_40222 uncharacterized protein K11511 APITD1; centromere protein S
D Bloom's syndrome complex (BTR)
E KLMA_50331 SGS1; ATP-dependent helicase SGS1 K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E KLMA_40206 TOP3; DNA topoisomerase 3 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E KLMA_60379 RMI1; RecQ-mediated genome instability protein 1 K15364 NCE4; RecQ-mediated genome instability protein 1
D FANCD2-I complex
D Downstream FA components
D Other FA pathway factors
E KLMA_80356 RAD51; DNA repair protein RAD51 K04482 RAD51; DNA repair protein RAD51
E KLMA_50440 TEL2; telomere length regulation protein TEL2 K11137 TELO2; telomere length regulation protein
E KLMA_40223 uncharacterized protein K15361 WDR48; WD repeat-containing protein 48
C Other DSBR factors
D Protein phosphatase 6
D Ubiquitin ligases
D Others
E KLMA_20732 SWT21; uncharacterized protein K23314 WRAP53; telomerase Cajal body protein 1
E KLMA_70244 uncharacterized protein K24755 WDR76; WD repeat-containing protein 76
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
D KLMA_30666 RAD30; DNA polymerase eta K03509 POLH; DNA polymerase eta [EC:2.7.7.7]
D KLMA_60218 REV1; DNA repair protein REV1 K03515 REV1; DNA repair protein REV1 [EC:2.7.7.-]
C B-family DNA polymerases
D KLMA_30452 REV3; DNA polymerase zeta catalytic subunit K02350 REV3L; DNA polymerase zeta [EC:2.7.7.7]
D KLMA_30389 REV7; DNA polymerase zeta processivity subunit K03508 POLZ2; DNA polymerase zeta [EC:2.7.7.7]
C A-family DNA polymerase
C Rad6 epistasis group
D KLMA_10247 UBC2; ubiquitin-conjugating enzyme E2 2 K10573 UBE2A; ubiquitin-conjugating enzyme E2 A [EC:2.3.2.23]
D KLMA_30501 RAD18; postreplication repair E3 ubiquitin-protein ligase RAD18 K10627 RAD18; E3 ubiquitin-protein ligase RAD18 [EC:2.3.2.27]
D KLMA_40074 RAD5; DNA repair protein RAD5 K15505 RAD5; DNA repair protein RAD5 [EC:5.6.2.-]
D KLMA_60358 MMS2; ubiquitin-conjugating enzyme variant MMS2 K10704 UBE2V; ubiquitin-conjugating enzyme E2 variant
D KLMA_30298 UBC13; ubiquitin-conjugating enzyme E2 13 K10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23]
C Other TLS factors
D KLMA_70334 POL30; proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
B Check point factors
C Rad9-Hus1-Rad1 complex
D KLMA_50007 RAD17; DNA damage checkpoint control protein RAD17 K02830 HRAD1; cell cycle checkpoint protein [EC:3.1.11.2]
C HRAD17(Rad24)-RFC complex
D KLMA_30288 RAD24; checkpoint protein RAD24 K06662 HRAD17; cell cycle checkpoint protein
D KLMA_10167 RFC4; replication factor C subunit 4 K10755 RFC2_4; replication factor C subunit 2/4
D KLMA_30044 RFC2; replication factor C subunit 2 K10755 RFC2_4; replication factor C subunit 2/4
D KLMA_70397 RFC3; replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
D KLMA_70341 RFC5; replication factor C subunit 5 K10756 RFC3_5; replication factor C subunit 3/5
C Rad17-Mec3-Ddc1 complex
D KLMA_50007 RAD17; DNA damage checkpoint control protein RAD17 K02830 HRAD1; cell cycle checkpoint protein [EC:3.1.11.2]
D KLMA_10221 MEC3; DNA damage checkpoint control protein MEC3 K02544 MEC3; G2-specific checkpoint protein
D KLMA_60371 DDC1; DNA damage checkpoint protein 1 K06663 DDC1; DNA damage checkpoint protein
C FPC (fork protection complex)
D KLMA_10101 TOF1; topoisomerase 1-associated factor 1 K10997 TIMELESS; replication fork protection complex subunit TIMELESS/Tof1/Swi1
D KLMA_40303 CSM3; chromosome segregation in meiosis protein 3 K10998 TIPIN; replication fork protection complex subunit TIPIN/Csm3/Swi3
D KLMA_10021 MRC1; mediator of replication checkpoint protein 1 K11272 MRC1; mediator of replication checkpoint protein 1
C Triple T complex
D KLMA_50440 TEL2; telomere length regulation protein TEL2 K11137 TELO2; telomere length regulation protein
D KLMA_60322 TTI1; TEL2-interacting protein 1 K20403 TTI1; TELO2-interacting protein 1
C BAG6-UBL4A-GET4 complex
D KLMA_40185 GET4; uncharacterized protein K23387 GET4; golgi to ER traffic protein 4
C Other check point factors
D KLMA_70154 TEL1; serine/threonine-protein kinase TEL1 K04728 ATM; serine-protein kinase ATM [EC:2.7.11.1]
D KLMA_50053 CHK1; serine/threonine-protein kinase CHK1 K02216 CHEK1; serine/threonine-protein kinase CHEK1 [EC:2.7.11.1]
D KLMA_20647 DUN1; DNA damage response protein kinase DUN1 K06641 CHEK2; serine/threonine-protein kinase CHEK2 [EC:2.7.11.1]
D KLMA_40317 MIH1; m-phase inducer phosphatase K02555 MIH1; M-phase inducer tyrosine phosphatase [EC:3.1.3.48]
D KLMA_20132 BMH2; protein BMH2 K06630 YWHAE; 14-3-3 protein epsilon
D KLMA_20209 RAD53; serine/threonine-protein kinase RAD53 K02831 RAD53; ser/thr/tyr protein kinase RAD53 [EC:2.7.11.-]
D KLMA_20118 RAD9; uncharacterized protein K06661 RAD9; DNA repair protein RAD9
D KLMA_70210 MEC1; serine/threonine-protein kinase MEC1 K02543 MEC1; cell cycle checkpoint protein MEC1
D KLMA_30355 AMN1; antagonist of mitotic exit network protein 1 K15081 AMN1; antagonist of mitotic exit network protein 1
D KLMA_50261 SWE1; mitosis inhibitor protein kinase SWE1 K03114 SWE1; mitosis inhibitor protein kinase SWE1 [EC:2.7.11.1]
D KLMA_50010 NDD1; nuclear division defective protein 1 K24663 NDD1; nuclear division defective protein 1
D KLMA_60534 FKH2; uncharacterized protein K24664 FKH; forkhead protein FKH
D KLMA_70279 VPS4; vacuolar protein sorting-associated protein 4 K12196 VPS4; vacuolar protein-sorting-associated protein 4
B Other factors with a suspected DNA repair function
C DNA polymerases
D KLMA_80023 POL5; DNA polymerase V K02331 POL5; DNA polymerase phi [EC:2.7.7.7]
C Nucleases
D KLMA_40057 PSO2; interstrand crosslink repair protein K15340 DCLRE1A; DNA cross-link repair 1A protein
D KLMA_30364 EXO5; defects in morphology protein 1 K17815 EXO5; exonuclease V [EC:3.1.-.-]
C Helicases
C PSO4 complex
D KLMA_10672 PRP19; pre-mRNA-splicing factor 19 K10599 PRPF19; pre-mRNA-processing factor 19 [EC:2.3.2.27]
D KLMA_40429 CEF1; pre-mRNA-splicing factor CEF1 K12860 CDC5L; pre-mRNA-splicing factor CDC5/CEF1
D KLMA_20205 PRP46; pre-mRNA-splicing factor PRP46 K12862 PLRG1; pleiotropic regulator 1
C Modulation of nucleotide pools
D KLMA_50459 DUT1; deoxyuridine 5'-triphosphate nucleotidohydrolase K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D KLMA_70170 RNR1; ribonucleoside-diphosphate reductase large chain 1 K10807 RRM1; ribonucleoside-diphosphate reductase subunit M1 [EC:1.17.4.1]
D KLMA_50048 RNR1; ribonucleoside-diphosphate reductase large chain 1 K10807 RRM1; ribonucleoside-diphosphate reductase subunit M1 [EC:1.17.4.1]
D KLMA_30199 RNR2; ribonucleoside-diphosphate reductase small chain 1 K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]
#
AProkaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D KLMA_20639 MGT1; methylated-DNA--protein-cysteine methyltransferase K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
D KLMA_80011 PHR1; deoxyribodipyrimidine photo-lyase K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]
C BER (base exicision repair)
D DNA glycosylases
E KLMA_40589 UNG1; uracil-DNA glycosylase K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E KLMA_20032 MAG1; DNA-3-methyladenine glycosylase K01247 alkA; DNA-3-methyladenine glycosylase II [EC:3.2.2.21]
E KLMA_20363 NTG2; DNA base excision repair N-glycosylase 2 K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
D RecJ
D DNA ligase
D DNA polymerase I
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E KLMA_30162 SRS2; ATP-dependent DNA helicase SRS2 K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E KLMA_30163 SRS2; ATP-dependent DNA helicase SRS2 K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase complex (RNAP)
E TRCF (transcription-repair coupling factor)
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
D Molecular matchmaker
D Strand discrimination factor
D DNA exonucleases
D DNA polymerase III holoenzyme
D DNA ligase
D Other MMR factors
E KLMA_30162 SRS2; ATP-dependent DNA helicase SRS2 K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E KLMA_30163 SRS2; ATP-dependent DNA helicase SRS2 K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D RecBC pathway proteins
D RecFOR pathway proteins
D AddAB pathway proteins
D Other HR factor
D Archaeal homologous recombinant proteins
C NHEJ (non-homologous end-joining)
D Two-component NHEJ DNA repair complex
D SHIIR (short-homology-independent illegitimate recombination)
E Facilitator
E Supressor
D SHDIR (short-homology-dependent illegitimate recombination)
E RecET pathway
E Facilitator
E Supressor
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
C Other SOS response factors
B Other factors with a suspected DNA repair function
C DNA polymerase
C DNA helicases
C Modulation of nucleotide pools
D KLMA_50459 DUT1; deoxyuridine 5'-triphosphate nucleotidohydrolase K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
C Others
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: March 29, 2024