+E Ubiquitin system KO
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Ubiquitin System - Kluyveromyces marxianus
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AUbiquitins and ubiquitin-like proteins
B Ubiquitins
C KLMA_20442 UBI4; ubiquitin K08770 UBC; ubiquitin C
C KLMA_30712 RPL40B; ubiquitin-60S ribosomal protein L40 K02927 RP-L40e; ubiquitin-large subunit ribosomal protein L40e
C KLMA_50559 ubi3; ubiquitin-40S ribosomal protein S27a K02977 RP-S27Ae; ubiquitin-small subunit ribosomal protein S27Ae
B Ubiquitin-like proteins (UBLs)
C KLMA_80372 ATG8; autophagy-related protein 8 K08341 GABARAP; GABA(A) receptor-associated protein
C KLMA_10251 ATG12; autophagy-related protein 12 K08336 ATG12; ubiquitin-like protein ATG12
C KLMA_50400 URM1; ubiquitin-related modifier 1 K12161 URM1; ubiquitin related modifier 1
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AUbiquitin-activating enzymes (E1)
B Ubiquitin activating enzyme
C KLMA_30033 UBA1; ubiquitin-activating enzyme E1 1 K03178 UBE1; ubiquitin-activating enzyme E1 [EC:6.2.1.45]
B UBL-activating enzymes
C KLMA_20499 AOS1; DNA damage tolerance protein RHC31 K10684 UBLE1A; ubiquitin-like 1-activating enzyme E1 A [EC:6.2.1.45]
C KLMA_20577 UBA2; ubiquitin-activating enzyme E1-like protein K10685 UBLE1B; ubiquitin-like 1-activating enzyme E1 B [EC:6.2.1.45]
C KLMA_80286 UBA3; NEDD8-activating enzyme E1 catalytic subunit K10686 UBA3; NEDD8-activating enzyme E1 [EC:6.2.1.64]
C KLMA_70450 ULA1; NEDD8-activating enzyme E1 regulatory subunit K04532 NAE1; NEDD8-activating enzyme E1 regulatory subunit
C KLMA_20445 UBA4; adenylyltransferase and sulfurtransferase UBA4 K11996 MOCS3; adenylyltransferase and sulfurtransferase [EC:2.7.7.80 2.8.1.11]
C KLMA_40433 ATG7; autophagy-related protein 7 K08337 ATG7; ubiquitin-like modifier-activating enzyme ATG7
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AUbiquitin-conjugating enzymes (E2)
B Ubiquitin-conjugating enzymes
C KLMA_10247 UBC2; ubiquitin-conjugating enzyme E2 2 K10573 UBE2A; ubiquitin-conjugating enzyme E2 A [EC:2.3.2.23]
C KLMA_70365 UBC4; ubiquitin-conjugating enzyme E2 4 K06689 UBE2D; ubiquitin-conjugating enzyme E2 D [EC:2.3.2.23]
C KLMA_40380 UBC7; ubiquitin-conjugating enzyme E2-18 kDa K04555 UBE2G2; ubiquitin-conjugating enzyme E2 G2 [EC:2.3.2.23]
C KLMA_10550 UBC8; ubiquitin-conjugating enzyme E2-24 kDa K10576 UBE2H; ubiquitin-conjugating enzyme E2 H [EC:2.3.2.23]
C KLMA_80362 UBC6; ubiquitin-conjugating enzyme E2 6 K04554 UBE2J2; ubiquitin-conjugating enzyme E2 J2 [EC:2.3.2.23]
C KLMA_40020 UBC1; ubiquitin-conjugating enzyme E2-24 kDa K04649 UBE2K; ubiquitin-conjugating enzyme (huntingtin interacting protein 2) [EC:2.3.2.23]
C KLMA_30298 UBC13; ubiquitin-conjugating enzyme E2 13 K10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23]
C KLMA_20706 CDC34; ubiquitin-conjugating enzyme E2-34 kDa K02207 UBE2R; ubiquitin-conjugating enzyme E2 R [EC:2.3.2.23]
C KLMA_20535 ubiquitin-conjugating enzyme E2-21 kDa K10689 PEX4; peroxin-4 [EC:2.3.2.23]
B UBL-conjugating enzymes
C KLMA_70064 UBC9; SUMO-conjugating enzyme UBC9 K10577 UBE2I; ubiquitin-conjugating enzyme E2 I
C KLMA_30316 UBC12; NEDD8-conjugating enzyme UBC12 K10579 UBE2M; ubiquitin-conjugating enzyme E2 M [EC:2.3.2.34]
C KLMA_60454 ATG3; autophagy-related protein 3 K08343 ATG3; ubiquitin-like-conjugating enzyme ATG3
C KLMA_80409 ATG10; autophagy-related protein 10 K08338 ATG10; ubiquitin-like-conjugating enzyme ATG10
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AUbiquitin ligases (E3)
B HECT type E3
C KLMA_60008 HUL5; probable E3 ubiquitin-protein ligase HUL5 K10589 UBE3C; ubiquitin-protein ligase E3 C [EC:2.3.2.26]
C KLMA_40489 uncharacterized protein K20803 UBE3D; ubiquitin-protein ligase E3 D [EC:2.3.2.26]
C KLMA_30059 UFD4; ubiquitin fusion degradation protein 4 K10590 TRIP12; E3 ubiquitin-protein ligase TRIP12 [EC:2.3.2.26]
C KLMA_70412 RSP5; E3 ubiquitin-protein ligase RSP5 K10591 NEDD4; E3 ubiquitin-protein ligase NEDD4 [EC:2.3.2.26]
C KLMA_40567 TOM1; probable E3 ubiquitin-protein ligase TOM1 K10592 HUWE1; E3 ubiquitin-protein ligase HUWE1 [EC:2.3.2.26]
C KLMA_10722 HUL4; probable E3 ubiquitin-protein ligase HUL4 K12232 HECTD2; E3 ubiquitin-protein ligase HECTD2 [EC:2.3.2.26]
C HECT type E3 associated proteins
B U-box type E3
C KLMA_60503 UFD2; ubiquitin conjugation factor E4 K10597 UBE4B; ubiquitin conjugation factor E4 B [EC:2.3.2.27]
C KLMA_10672 PRP19; pre-mRNA-splicing factor 19 K10599 PRPF19; pre-mRNA-processing factor 19 [EC:2.3.2.27]
B Single Ring-finger type E3
C BRE1 proteins
D KLMA_40454 BRE1; E3 ubiquitin-protein ligase BRE1 K10696 BRE1; E3 ubiquitin-protein ligase BRE1 [EC:2.3.2.27]
C CBL proteins
C SINA (Seven in absentia) proteins
C Ligand of Numb proteins
C March proteins
D KLMA_40346 SSM4; protein SSM4 K10661 MARCH6; E3 ubiquitin-protein ligase MARCH6 [EC:2.3.2.27]
C MDM2/MDM4 proteins
C NFX1 proteins
D KLMA_80129 FAP1; FKBP12-associated protein 1 K12236 NFX1; transcriptional repressor NF-X1
C Pellino proteins
C Peripheral membrane proteins
D KLMA_60093 PEX10; peroxisome biogenesis factor 10 K13346 PEX10; peroxin-10
D KLMA_40387 peroxisome assembly protein 12 K13345 PEX12; peroxin-12
D KLMA_80009 peroxisomal biogenesis factor 2 K06664 PEX2; peroxin-2
C RBR proteins
D KLMA_10605 uncharacterized protein K11968 ARIH1; ariadne-1 [EC:2.3.2.31]
D KLMA_50163 ITT1; translation termination inhibitor protein ITT1 K11971 RNF14; E3 ubiquitin-protein ligase RNF14 [EC:2.3.2.31]
C TRAF proteins
C TRIM/RBCC proteins
C UBR box proteins
D KLMA_30209 UBR1; E3 ubiquitin-protein ligase UBR1 K10625 UBR1; E3 ubiquitin-protein ligase UBR1 [EC:2.3.2.27]
D KLMA_30137 mlo2; protein mlo2 K11979 UBR7; E3 ubiquitin-protein ligase UBR7 [EC:2.3.2.27]
C ATL proteins
C Other single Ring-finger type E3
D KLMA_60321 ETP1; RING finger protein ETP1 K10632 BRAP; BRCA1-associated protein [EC:2.3.2.27]
D KLMA_70177 MOT2; general negative regulator of transcription subunit 4 K10643 CNOT4; CCR4-NOT transcription complex subunit 4 [EC:2.3.2.27]
D KLMA_30560 RKR1; uncharacterized protein K22377 LTN1; E3 ubiquitin-protein ligase listerin [EC:2.3.2.27]
D KLMA_30501 RAD18; postreplication repair E3 ubiquitin-protein ligase RAD18 K10627 RAD18; E3 ubiquitin-protein ligase RAD18 [EC:2.3.2.27]
D KLMA_10617 MAG2; RING-finger protein MAG2 K26979 RNF10; E3 ubiquitin-protein ligase RNF10 [EC:2.3.2.27]
D KLMA_20322 SNU66; U4/U6.U5 small nuclear ribonucleoprotein K11984 SART1; U4/U6.U5 tri-snRNP-associated protein 1
D KLMA_20133 IRC20; hypothetical protein K15710 SHPRH; E3 ubiquitin-protein ligase SHPRH [EC:5.6.2.- 2.3.2.27]
D KLMA_10257 HRD1; ERAD-associated E3 ubiquitin-protein ligase HRD1 K10601 SYVN1; E3 ubiquitin-protein ligase synoviolin [EC:2.3.2.27]
D KLMA_60092 uncharacterized protein K22381 ZNF598; E3 ubiquitin-protein ligase ZNF598 [EC:2.3.2.27]
D KLMA_60330 hypothetical protein K16276 K16276; zinc finger protein-like protein
D KLMA_60318 TUL1; transmembrane E3 ubiquitin-protein ligase 1 K23788 TUL1; transmembrane E3 ubiquitin-protein ligase [EC:2.3.2.27]
D KLMA_60242 DMA2; E3 ubiquitin-protein ligase DMA2 K23787 DMA1_2; E3 ubiquitin-protein ligase DMA1/2 [EC:2.3.2.27]
B Atypical E3
C KLMA_80079 NSE1; non-structural maintenance of chromosomes element 1 K22817 NSMCE1; non-structural maintenance of chromosomes element 1 [EC:2.3.2.27]
B UBL E3 ligases
C KLMA_70161 HRT1; RING-box protein HRT1 K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
C KLMA_30651 SIZ1; E3 SUMO-protein ligase SIZ1 K04706 PIAS1; E3 SUMO-protein ligase PIAS1 [EC:2.3.2.-]
C KLMA_10563 MMS21; E3 SUMO-protein ligase MMS21 K22756 NSMCE2; E3 SUMO-protein ligase NSE2 [EC:2.3.2.-]
C KLMA_40469 CST9; hypothetical protein K25662 RNF212; E3 SUMO-protein ligase RNF212 [EC:2.3.2.-]
C KLMA_50485 DCN1; defective in cullin neddylation protein 1 K17822 DCUN1D1_2; DCN1-like protein 1/2
B Multi subunit Ring-finger type E3
C SCF complex
D Ring finger protein
E KLMA_70161 HRT1; RING-box protein HRT1 K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
D Cullin
E KLMA_60494 CDC53; cell division control protein 53 K03347 CUL1; cullin 1
D Adaptor protein
E KLMA_60103 SKP1; suppressor of kinetochore protein 1 K03094 SKP1; S-phase kinase-associated protein 1
D Target recognizing subunit (F-box)
E KLMA_40339 MET30; F-box protein MET30 K10259 MET30; F-box and WD-40 domain protein MET30
E KLMA_20775 CDC4; WD40 domain-containing protein K03361 CDC4; F-box and WD-40 domain protein CDC4
E KLMA_40439 Fbxl7; hypothetical protein K10273 FBXL7; F-box and leucine-rich repeat protein 7
E KLMA_40344 JHD1; JmjC domain-containing histone demethylation protein 1 K10276 FBXL10_11; F-box and leucine-rich repeat protein 10/11 [EC:1.14.11.27]
E KLMA_70111 GRR1; SCF E3 ubiquitin ligase complex F-box protein GRR1 K03360 GRR1; F-box and leucine-rich repeat protein GRR1
E KLMA_10403 DIA2; protein DIA2 K15068 DIA2; protein DIA2
E KLMA_40157 HRT3; F-box protein HRT3 K10295 FBXO9; F-box protein 9
E KLMA_50275 F-box-like family protein K15070 MDM30; mitochondrial distribution and morphology protein 30
E KLMA_10149 RCY1; recyclin-1 K15071 RCY1; recyclin-1
E KLMA_50083 SAF1; SCF-associated factor 1 K15072 SAF1; SCF-associated factor 1
E KLMA_70263 UFO1; ubiquitin ligase complex F-box protein UFO1 K15073 UFO1; ubiquitin ligase complex F-box protein UFO1
C Cul2 complex
D Ring finger protein
E KLMA_70161 HRT1; RING-box protein HRT1 K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
D Cullin
D Adoptor protein
E KLMA_60398 elongin-C K03872 ELOC; elongin-C
D Target recognizing subunit
C Cul3 complex
D Ring finger protein
E KLMA_70161 HRT1; RING-box protein HRT1 K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
D Cullin
E KLMA_40036 CUL3; cullin-3 K03869 CUL3; cullin 3
D Adoptor and target recognizing subunit (BTB)
E KLMA_50388 uncharacterized protein K10520 ABTB1; ankyrin repeat and BTB/POZ domain-containing protein 1
C Cul4 complex
D Ring finger protein
E KLMA_70161 HRT1; RING-box protein HRT1 K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
D Cullin
D Adoptor protein
D Target recognizing subunit (DCAF)
E KLMA_50334 uncharacterized protein K11805 DCAF7; DDB1- and CUL4-associated factor 7
E KLMA_30222 DCAF13; protein SOF1 K11806 DCAF13; DDB1- and CUL4-associated factor 13
E KLMA_10052 GID7; glucose-induced degradation protein 7 K22382 WDR26; WD repeat-containing protein 26
E KLMA_70244 uncharacterized protein K24755 WDR76; WD repeat-containing protein 76
C Cul5 complex
D Ring finger protein
D Cullin
D Adoptor protein
E KLMA_60398 elongin-C K03872 ELOC; elongin-C
D Target recognizing subunit
C Cul7 complex
D Ring finger protein
E KLMA_70161 HRT1; RING-box protein HRT1 K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
D Cullin
D Adaptor protein
E KLMA_60103 SKP1; suppressor of kinetochore protein 1 K03094 SKP1; S-phase kinase-associated protein 1
D Target recognizing subunit
C Cul8 complex
D Ring finger protein
E KLMA_70161 HRT1; RING-box protein HRT1 K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
D Cullin
E KLMA_50091 cullin K26124 RTT101; cullin 8
D Adaptor protein
D Target recognizing subunit
E KLMA_40034 MMS22; methyl methanesulfonate-sensitivity protein 22 K26122 MMS22; E3 ubiquitin-protein ligase substrate receptor MMS22
C Cul9 complex
D Ring finger protein
E KLMA_70161 HRT1; RING-box protein HRT1 K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
D Cullin
C APC/C
D Ring finger protein
E KLMA_60132 APC11; anaphase-promoting complex subunit 11 K03358 APC11; anaphase-promoting complex subunit 11
D Cullin
E KLMA_50484 APC2; anaphase-promoting complex subunit 2 K03349 APC2; anaphase-promoting complex subunit 2
D Target recognizing subunit
E KLMA_20224 CDC20; APC/C activator protein CDC20 K03363 CDC20; cell division cycle 20, cofactor of APC complex
E KLMA_10450 CDH1; APC/C activator protein CDH1 K03364 CDH1; cell division cycle 20-like protein 1, cofactor of APC complex
E KLMA_60058 AMA1; meiosis-specific APC/C activator protein AMA1 K12782 AMA1; meiosis-specific APC/C activator protein AMA1
D Other subunits
E KLMA_20750 APC1; anaphase-promoting complex subunit 1 K03348 APC1; anaphase-promoting complex subunit 1
E KLMA_80384 CDC27; anaphase-promoting complex subunit CDC27 K03350 APC3; anaphase-promoting complex subunit 3
E KLMA_40146 hypothetical protein K03351 APC4; anaphase-promoting complex subunit 4
E KLMA_30447 anaphase-promoting complex subunit 5 K03352 APC5; anaphase-promoting complex subunit 5
E KLMA_40367 CDC16; hypothetical protein K03353 APC6; anaphase-promoting complex subunit 6
E KLMA_10325 CDC23; anaphase-promoting complex subunit CDC23 K03355 APC8; anaphase-promoting complex subunit 8
E KLMA_30701 DOC1; anaphase-promoting complex subunit DOC1 K03357 APC10; anaphase-promoting complex subunit 10
E KLMA_60100 hypothetical protein K12416 SWM1; anaphase-promoting complex subunit SWM1
C BRCC complex
D KLMA_80356 RAD51; DNA repair protein RAD51 K04482 RAD51; DNA repair protein RAD51
C KPC complex
C LUBAC complex
C CTLH complex
D KLMA_60399 RMD5; sporulation protein RMD5 K23333 RMND5; E3 ubiquitin-protein transferase RMND5 [EC:2.3.2.27]
D KLMA_30686 VID30; vacuolar import and degradation protein 30 K23334 RANBP9_10; Ran-binding protein 9/10
D KLMA_80138 FYV10; protein FYV10 K18624 MAEA; macrophage erythroblast attacher
D KLMA_80284 VID24; vacuolar import and degradation protein 24 K23335 GID4; glucose-induced degradation protein 4
D KLMA_40059 GID8; glucose-induced degradation protein 8 K23338 GID8; glucose-induced degradation protein 8
D KLMA_10052 GID7; glucose-induced degradation protein 7 K22382 WDR26; WD repeat-containing protein 26
C ERAD complex
C LMBR1L-GP78-UBAC2 complex
C SLX5-SLX8 complex
D KLMA_10201 SLX5; E3 ubiquitin-protein ligase complex SLX5-SLX8 subunit SLX5 K22645 SLX5; E3 ubiquitin-protein ligase complex SLX5-SLX8 subunit SLX5 [EC:2.3.2.27]
C Multi subunit type E3 associated proteins
D KLMA_60107 UBX5; UBX domain-containing protein 5 K24350 UBXN7; UBX domain-containing protein 7
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ADeubiquitinating enzyme (DUB)
B Ubiquitin-specific proteases (UBPs)
C UCH
D KLMA_20015 YUH1; ubiquitin carboxyl-terminal hydrolase YUH1 K05609 UCHL3; ubiquitin carboxyl-terminal hydrolase L3 [EC:3.4.19.12]
D KLMA_20017 uch2; ubiquitin carboxyl-terminal hydrolase isozyme L5 K05610 UCHL5; ubiquitin carboxyl-terminal hydrolase L5 [EC:3.4.19.12]
C UBP/USP
D KLMA_40109 UBP14; ubiquitin carboxyl-terminal hydrolase 14 K11836 USP5_13; ubiquitin carboxyl-terminal hydrolase 5/13 [EC:3.4.19.12]
D KLMA_80201 UBP15; ubiquitin carboxyl-terminal hydrolase 15 K11838 USP7; ubiquitin carboxyl-terminal hydrolase 7 [EC:3.4.19.12]
D KLMA_20028 DOA4; ubiquitin carboxyl-terminal hydrolase 4 K11839 USP8; ubiquitin carboxyl-terminal hydrolase 8 [EC:3.4.19.12]
D KLMA_20429 UBP3; ubiquitin carboxyl-terminal hydrolase 3 K11841 USP10; ubiquitin carboxyl-terminal hydrolase 10 [EC:3.4.19.12]
D KLMA_10531 UBP6; ubiquitin carboxyl-terminal hydrolase 6 K11843 USP14; ubiquitin carboxyl-terminal hydrolase 14 [EC:3.4.19.12]
D KLMA_10308 UBP8; ubiquitin carboxyl-terminal hydrolase 8 K11366 USP22_27_51; ubiquitin carboxyl-terminal hydrolase 22/27/51 [EC:3.4.19.12]
D KLMA_20610 UBP2; ubiquitin carboxyl-terminal hydrolase 2 K11849 USP25; ubiquitin carboxyl-terminal hydrolase 25 [EC:3.4.19.12]
D KLMA_80111 UBP1; ubiquitin carboxyl-terminal hydrolase 1 K11870 UBP1; ubiquitin carboxyl-terminal hydrolase 1 [EC:3.4.19.12]
D KLMA_30723 UBP11; ubiquitin carboxyl-terminal hydrolase 7 K11871 UBP7_11; ubiquitin carboxyl-terminal hydrolase 7/11 [EC:3.4.19.12]
D KLMA_80360 UBP13; ubiquitin carboxyl-terminal hydrolase 13 K11872 UBP9_13; ubiquitin carboxyl-terminal hydrolase 9/13 [EC:3.4.19.12]
D KLMA_20735 UBP10; ubiquitin carboxyl-terminal hydrolase 10 K11873 UBP10; ubiquitin carboxyl-terminal hydrolase 10 [EC:3.4.19.12]
D KLMA_10756 UBP16; hypothetical protein K11874 UBP16; ubiquitin carboxyl-terminal hydrolase 16 [EC:3.4.19.12]
C OTU
D KLMA_60315 OTU2; OTU domain-containing protein 2 K18342 OTUD6; OTU domain-containing protein 6 [EC:3.4.19.12]
C MJD
C MINDY
D KLMA_60366 uncharacterized protein K01309 MINDY1_2; ubiquitin carboxyl-terminal hydrolase MINDY-1/2 [EC:3.4.19.12]
C JAMM
D KLMA_70440 RPN11; 26S proteasome regulatory subunit RPN11 K03030 PSMD14; 26S proteasome regulatory subunit N11
C PPPDE
C ZUFSP
C BRISC complex
B UBL-specific proteases (ULPs)
C KLMA_20214 ULP1; SUMO protease ULP1 K08592 SENP1; sentrin-specific protease 1 [EC:3.4.22.68]
C KLMA_40345 ulp2; ubiquitin-like-specific protease 2 K08596 SENP7; sentrin-specific protease 7 [EC:3.4.22.68]
C KLMA_20015 YUH1; ubiquitin carboxyl-terminal hydrolase YUH1 K05609 UCHL3; ubiquitin carboxyl-terminal hydrolase L3 [EC:3.4.19.12]
C COP9 signalosome (CSN) complex
D KLMA_20733 RRI1; COP9 signalosome complex subunit 5 K09613 COPS5; COP9 signalosome complex subunit 5 [EC:3.4.-.-]
D KLMA_50551 CSN9; COP9 signalosome complex subunit 9 K24365 CSN9; COP9 signalosome complex subunit 9
D KLMA_40409 PCI8; COP9 signalosome complex subunit 11 K24367 PCI8; COP9 signalosome complex subunit 11
D KLMA_70120 CSN12; COP9 signalosome complex subunit 12 K24364 CSN12; COP9 signalosome complex subunit 12
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: June 3, 2024