+D Protein KO
#
Membrane Trafficking - Kluyveromyces marxianus
%
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AExocytosis
B Calcium ion-dependent exocytosis
C Synaptotagmins
C Septins
D KLMA_10680 CDC3; cell division control protein 3 K16944 SEPT7; septin 7
C DOC-2 proteins
C Acrosomal exocytosis proteins
D KLMA_20554 PKH3; serine/threonine-protein kinase PKH3 K06276 PDPK1; 3-phosphoinositide dependent protein kinase-1 [EC:2.7.11.1]
D KLMA_80265 PKH1; uncharacterized protein K06276 PDPK1; 3-phosphoinositide dependent protein kinase-1 [EC:2.7.11.1]
C Phospholipases
D KLMA_80017 plc1; APC/C-CDH1 modulator 1 K05857 PLCD; phosphatidylinositol phospholipase C, delta [EC:3.1.4.11]
D KLMA_40231 SPO14; phospholipase D1 K01115 PLD1_2; phospholipase D1/2 [EC:3.1.4.4]
C Kinases and associated proteins
D KLMA_50129 MSS4; probable phosphatidylinositol-4-phosphate 5-kinase MSS4 K00889 PIP5K; 1-phosphatidylinositol-4-phosphate 5-kinase [EC:2.7.1.68]
D KLMA_30058 STE20; serine/threonine-protein kinase STE20 K04409 PAK1; p21-activated kinase 1 [EC:2.7.11.1]
D KLMA_10663 NDK1; nucleoside diphosphate kinase K00940 ndk; nucleoside-diphosphate kinase [EC:2.7.4.6]
D KLMA_40156 KIN1; serine/threonine-protein kinase KIN2 K19852 KIN1_2; serine/threonine protein kinase KIN1/2 [EC:2.7.11.1]
C Others
D KLMA_20609 FRQ1; calcium-binding protein NCS-1 K19932 NCS1; neuronal calcium sensor
B Small GTPases and associated proteins
C Rab GTPases
D KLMA_30127 SEC4; ras-related protein SEC4 K07901 RAB8A; Ras-related protein Rab-8A
C Rab associated proteins
D KLMA_40476 myosin light chain 2 K02183 CALM; calmodulin
D KLMA_80290 CMD1; calmodulin K02183 CALM; calmodulin
D KLMA_10103 SEC2; rab guanine nucleotide exchange factor SEC2 K19940 SEC2; Rab guanine nucleotide exchange factor SEC2
D KLMA_50516 SEC1; protein transport protein SEC1 K15292 STXBP1; syntaxin-binding protein 1
D KLMA_70129 SRO77; protein SNI2 K08518 STXBP5; syntaxin-binding protein 5
D KLMA_10399 MSB3; GTPase-activating protein GYP3 K19953 GRTP1; TBC1 domain family member 6
D KLMA_50442 MDR1; GTPase-activating protein GYP2 K19951 TBC1D8_9; TBC1 domain family member 8/9
D KLMA_30513 PEX5; peroxisomal targeting signal receptor K13342 PEX5; peroxin-5
D KLMA_20828 MRS6; rab proteins geranylgeranyltransferase component A K23460 CHM; Rab proteins geranylgeranyltransferase component A
D KLMA_20695 BET4; protein prenyltransferase K14050 RABGGTA; geranylgeranyl transferase type-2 subunit alpha [EC:2.5.1.60]
D KLMA_20502 BET2; geranylgeranyl transferase type-2 subunit beta K05956 RABGGTB; geranylgeranyl transferase type-2 subunit beta [EC:2.5.1.60]
D KLMA_10727 RAV1; regulator of V-ATPase in vacuolar membrane protein 1 K24155 DMXL; rabconnectin-3a
C Rho GTPases
D KLMA_50127 CDC42; cell division control protein 42 K04393 CDC42; cell division control protein 42
C Other small GTPases and associated proteins
B Tethering complex
C Exocyst complex
D KLMA_50374 SEC3; exocyst complex component SEC3 K19983 EXOC1; exocyst complex component 1
D KLMA_50522 SEC5; exocyst complex component SEC5 K17637 EXOC2; exocyst complex component 2
D KLMA_70168 SEC6; exocyst complex component SEC6 K06110 EXOC3; exocyst complex component 3
D KLMA_20081 SEC8; exocyst complex component SEC8 K06111 EXOC4; exocyst complex component 4
D KLMA_50557 SEC10; exocyst complex component SEC10 K19984 EXOC5; exocyst complex component 5
D KLMA_30694 SEC15; exocyst complex component SEC15 K19985 EXOC6; exocyst complex component 6
D KLMA_30171 EXO70; exocyst complex protein EXO70 K07195 EXOC7; exocyst complex component 7
D KLMA_20078 EXO84; exocyst complex component EXO84 K19986 EXOC8; exocyst complex component 8
C Exocyst complex assembly proteins
D KLMA_80402 probable 26S proteasome complex subunit SEM1 K10881 SHFM1; 26 proteasome complex subunit DSS1
D KLMA_60143 TPM2; tropomyosin-2 K17945 TPM1_2; tropomyosin, fungi type
B Others
C Exomer complex
D KLMA_20465 CHS5; chitin biosynthesis protein CHS5 K19877 CHS5; chitin biosynthesis protein CHS5
D KLMA_30156 CHS6; chitin biosynthesis protein CHS6 K19880 CHS6; Chs5-Arf1p-binding protein CHS6/BCH2
D KLMA_60289 BUD7; protein BCH1 K19881 BUD7; Chs5-Arf1p-binding protein BUD7/BCH1
C Others
D KLMA_40017 protein MSO1 K19992 MSO1; protein MSO1
D KLMA_50354 PEP7; vacuolar segregation protein PEP7 K12481 RBSN; rabenosyn-5
D KLMA_10357 SFH5; phosphatidylinositol transfer protein SFH5 K19996 SFH5; phosphatidylinositol transfer protein SFH5
#
ASNARE
B Syntaxin (Qa)
C Stx-PM
D KLMA_70218 SSO1; protein SSO2 K08486 STX1B_2_3; syntaxin 1B/2/3
C Stx-Endo
D KLMA_80235 VAM3; syntaxin VAM3 K21155 VAM3; syntaxin VAM3
C Stx-TGN / EE
D KLMA_10527 TLG2; t-SNARE affecting a late Golgi compartment protein 2 K08489 STX16; syntaxin 16
C Stx-cisGolgi
D KLMA_40085 SED5; integral membrane protein SED5 K08490 STX5; syntaxin 5
C Stx-sER
C Stx-rER
D KLMA_10413 UFE1; syntaxin UFE1 K08492 STX18; syntaxin 18
B SNAP-25[N] (Qb)
C Vti1
D KLMA_30336 VTI1; t-SNARE VTI1 K08493 VTI1; vesicle transport through interaction with t-SNAREs 1
C NPSN
C Gos1 (Gos28)
D KLMA_80410 GOS1; protein transport protein GOS1 K08495 GOSR1; golgi SNAP receptor complex member 1
C Bos1 / Membrin
D KLMA_70031 BOS1; protein transport protein BOS1 K08496 GOSR2; golgi SNAP receptor complex member 2
C Sec20
D KLMA_80274 SEC20; uncharacterized protein K08497 SEC20; protein transport protein SEC20
B SNAP-25[C] (Qc)
C STX6
C STX8
D KLMA_20360 SYN8; syntaxin-8 K08501 STX8; syntaxin 8
D KLMA_30673 vacuolar morphogenesis protein 7 K08502 VAM7; regulator of vacuolar morphogenesis
C STX10
C Bet1
D KLMA_50394 BET1; protein transport protein BET1 K08504 BET1; blocked early in transport 1
C Sft1
C Syp7
C Use1
D KLMA_20410 USE1; protein transport protein USE1 K08507 USE1; unconventional SNARE in the endoplasmic reticulum protein 1
B SNAP-25 (Qb,c)
C SNAP-23
C SNAP-25
D KLMA_10594 SEC9; protein transport protein SEC9 K19950 SEC9; protein transport protein SEC9
C SNAP-29
C SNAP-47
B VAMP, Ykt6, Sec22 (R)
C VAMP
D KLMA_50112 SNC2; uncharacterized protein K08513 VAMP4; vesicle-associated membrane protein 4
D KLMA_40152 NYV1; vacuolar V-SNARE NYV1 K08564 NYV1; vacuolar v-SNARE NYV1
C Ykt6
D KLMA_10622 YKT6; palmitoyltransferase YKT6 K08516 YKT6; synaptobrevin homolog YKT6
C Sec22
D KLMA_40183 SEC22; protein transport protein SEC22 K08517 SEC22; vesicle transport protein SEC22
C Tomosyn
D KLMA_70129 SRO77; protein SNI2 K08518 STXBP5; syntaxin-binding protein 5
C Putative SNAREs
B SNARE associated proteins
C Syntaxin-binding proteins
D KLMA_50516 SEC1; protein transport protein SEC1 K15292 STXBP1; syntaxin-binding protein 1
D KLMA_50568 SLY1; protein SLY1 K19998 SCFD1; sec1 family domain-containing protein 1
C Palmitoyltransferases
D KLMA_20624 PFA3; palmitoyltransferase PFA3 K20028 ZDHHC2_15_20; palmitoyltransferase ZDHHC2/15/20 [EC:2.3.1.225]
D KLMA_40160 SWF1; palmitoyltransferase SWF1 K20003 ZDHHC4; palmitoyltransferase ZDHHC4 [EC:2.3.1.225]
D KLMA_60095 AKR1; palmitoyltransferase AKR1 K20032 ZDHHC13_17; palmitoyltransferase ZDHHC13/17 [EC:2.3.1.225]
C Others
D KLMA_30551 SEC18; vesicular-fusion protein SEC18 K06027 NSF; vesicle-fusing ATPase [EC:3.6.4.6]
D KLMA_70106 SEC17; vesicular-fusion protein SEC17 K15296 NAPA; alpha-soluble NSF attachment protein
D KLMA_30406 SNX4; sorting nexin-4 K17919 SNX4; sorting nexin-4
D KLMA_40610 SNX41; sorting nexin-41 K21996 SNX41_42; sorting nexin-41/42
D KLMA_80093 ATG20; autophagy-related protein 20 K21996 SNX41_42; sorting nexin-41/42
D KLMA_20611 VPS74; vacuolar protein sorting-associated protein 74 K15620 GOLPH3; golgi phosphoprotein 3
D KLMA_60484 CDC48; cell division control protein 48 K13525 VCP; transitional endoplasmic reticulum ATPase
D KLMA_80346 SHP1; UBX domain-containing protein 1 K14012 NSFL1C; UBX domain-containing protein 1
D KLMA_30587 VTS1; protein VTS1 K27407 VTS1; RNA-binding protein VTS1
#
AEndocytosis
B Clathrin-mediated endocytosis
C Clathrin
D KLMA_20264 CHC1; clathrin heavy chain K04646 CLTC; clathrin heavy chain
C Dynamin
D KLMA_20110 DNM1; dynamin-related protein DNM1 K17065 DNM1L; dynamin 1-like protein [EC:3.6.5.5]
C AP-2 complex
D KLMA_70342 APL3; AP-2 complex subunit alpha K11824 AP2A; AP-2 complex subunit alpha
D KLMA_80077 APL1; AP-2 complex subunit beta K11825 AP2B1; AP-2 complex subunit beta-1
D KLMA_10175 APM4; AP-2 complex subunit mu K11826 AP2M1; AP-2 complex subunit mu-1
D KLMA_50225 APS2; AP-2 complex subunit sigma K11827 AP2S1; AP-2 complex subunit sigma-1
C Other core components
D KLMA_80262 HOF1; cytokinesis protein 2 K20042 FCHO; F-BAR domain only protein
D KLMA_70254 ENT2; epsin-2 K12471 EPN; epsin
D KLMA_40449 ENT3; epsin-3 K12471 EPN; epsin
D KLMA_50500 ENT5; epsin-like protein K12471 EPN; epsin
D KLMA_70099 EDE1; EH domain-containing and endocytosis protein 1 K12472 EPS15; epidermal growth factor receptor substrate 15
D KLMA_10339 YAP1801; clathrin coat assembly protein AP180A K20044 PICALM; phosphatidylinositol-binding clathrin assembly protein
D KLMA_20579 RVS167; uncharacterized protein K12562 AMPH; amphiphysin
D KLMA_50160 BAR super family and SH3 K12562 AMPH; amphiphysin
D KLMA_50155 SLA1; actin cytoskeleton-regulatory complex protein SLA1 K20046 SLA1; actin cytoskeleton-regulatory complex protein SLA1
D KLMA_50368 PAN1; actin cytoskeleton-regulatory complex protein PAN1 K20047 PAN1; actin cytoskeleton-regulatory complex protein PAN1
D KLMA_30385 END3; actin cytoskeleton-regulatory complex protein END3 K20048 END3; actin cytoskeleton-regulatory complex protein END3
D KLMA_20459 SSA2; heat shock protein SSA2 K03283 HSPA1_6_8; heat shock 70kDa protein 1/6/8
D KLMA_80367 SSA3; heat shock protein SSA3 K03283 HSPA1_6_8; heat shock 70kDa protein 1/6/8
D KLMA_50592 SSB; heat shock protein SSB K03283 HSPA1_6_8; heat shock 70kDa protein 1/6/8
C Low-density lipoprotein receptor (LDLR) family proteins
C LDLR adaptor proteins
D KLMA_50129 MSS4; probable phosphatidylinositol-4-phosphate 5-kinase MSS4 K00889 PIP5K; 1-phosphatidylinositol-4-phosphate 5-kinase [EC:2.7.1.68]
C GPCR adaptor proteins
D KLMA_50122 LDB19; protein LDB19 K20059 LDB19; arrestin-related trafficking adapter 1
D KLMA_70136 ECM21; protein ECM21 K20060 ECM21; arrestin-related trafficking adapter 2/8
D KLMA_30172 ALY2; uncharacterized protein K20061 ALY1_2; arrestin-related trafficking adapter 3/6
D KLMA_20475 ROD1; protein ROD1 K20062 ART4_5_7; arrestin-related trafficking adapter 4/5/7
D KLMA_50276 ART5; arrestin-related trafficking adapter 5 K20062 ART4_5_7; arrestin-related trafficking adapter 4/5/7
D KLMA_30383 RIM8; pH-response regulator protein PalF/RIM8 K20063 RIM8; arrestin-related trafficking adapter 9
C Receptor tyrosine kinase (RTK) adaptor proteins
C Inositol 5-phosphatases
D KLMA_60227 INP53; inositol polyphosphate 5-phosphatase K20279 SYNJ; synaptojanin [EC:3.1.3.36]
D KLMA_50389 INP51; inositol-1 K20279 SYNJ; synaptojanin [EC:3.1.3.36]
C Kinases
D KLMA_80133 PRK1; actin-regulating kinase PRK1 K08853 AAK; AP2-associated kinase [EC:2.7.11.1]
D KLMA_60362 SCY1; protein kinase-like protein SCY1 K17541 SCYL2; SCY1-like protein 2
C Ubiquitin E3 ligases
D KLMA_70412 RSP5; E3 ubiquitin-protein ligase RSP5 K10591 NEDD4; E3 ubiquitin-protein ligase NEDD4 [EC:2.3.2.26]
C Others
D KLMA_10141 SLA2; uncharacterized protein K20040 HIP1R; huntingtin-interacting protein 1-related protein
D KLMA_50013 cal1; uncharacterized protein K08054 CANX; calnexin
B Lipid raft mediated endocytosis
C Caveolin-mediated endocytosis
D KLMA_20110 DNM1; dynamin-related protein DNM1 K17065 DNM1L; dynamin 1-like protein [EC:3.6.5.5]
D KLMA_70130 PKC1; protein kinase C-like 1 K02677 PRKCA; classical protein kinase C alpha type [EC:2.7.11.13]
C Flotillin-dependent endocytosis
C GRAF1-dependent endocytosis
D KLMA_50127 CDC42; cell division control protein 42 K04393 CDC42; cell division control protein 42
D KLMA_60505 ARF1; ADP-ribosylation factor K07937 ARF1_2; ADP-ribosylation factor 1/2
C Arf6-dependent endocytosis
D KLMA_80220 ARF3; ADP-ribosylation factor 3 K07941 ARF6; ADP-ribosylation factor 6
C RhoA-dependent endocytosis
D KLMA_70268 RHO1; GTP-binding protein Rho1 K04513 RHOA; Ras homolog gene family, member A
D KLMA_20110 DNM1; dynamin-related protein DNM1 K17065 DNM1L; dynamin 1-like protein [EC:3.6.5.5]
B Phagocytosis
C Fc receptors
C Integrins (complement receptors)
C Opsonins
C Toll-like receptors
C C-lectin receptors
C Scavenger receptors
C Coronins
C Others
D KLMA_30106 MYO1; myosin-1 K10356 MYO1; myosin I
B Macropinocytosis
C Ras GTPases
D KLMA_80228 RAS2; hypothetical protein K07827 KRAS; GTPase KRas
D KLMA_50127 CDC42; cell division control protein 42 K04393 CDC42; cell division control protein 42
C Kinases
D KLMA_50575 VPS34; phosphatidylinositol 3-kinase VPS34 K00914 PIK3C3; phosphatidylinositol 3-kinase [EC:2.7.1.137]
D KLMA_20473 FAB1; 1-phosphatidylinositol-3-phosphate 5-kinase FAB1 K00921 PIKFYVE; 1-phosphatidylinositol-3-phosphate 5-kinase [EC:2.7.1.150]
D KLMA_30058 STE20; serine/threonine-protein kinase STE20 K04409 PAK1; p21-activated kinase 1 [EC:2.7.11.1]
C Phospholipase C
D KLMA_80017 plc1; APC/C-CDH1 modulator 1 K05857 PLCD; phosphatidylinositol phospholipase C, delta [EC:3.1.4.11]
C Sorting nexins
D KLMA_30270 VPS5; vacuolar protein sorting-associated protein 5 K17917 SNX1_2; sorting nexin-1/2
C Others
B Bin/Amphiphysin/Rvs (BAR) family proteins
C N-BAR proteins
D KLMA_20579 RVS167; uncharacterized protein K12562 AMPH; amphiphysin
D KLMA_50160 BAR super family and SH3 K12562 AMPH; amphiphysin
D KLMA_20100 RVS161; uncharacterized protein K20120 BIN3; bridging integrator 3
C F-BAR proteins
D KLMA_60240 BZZ1; protein BZZ1 K20121 FNBP1; formin-binding protein 1
D KLMA_80262 HOF1; cytokinesis protein 2 K20042 FCHO; F-BAR domain only protein
D KLMA_50090 RGD1; RHO GTPase-activating protein RGD1 K20643 RGD1; Rho GTPase-activating protein RGD1
C I-BAR proteins
B Rab GTPases and associated proteins
C Rab GTPases
D KLMA_80212 VPS21; vacuolar protein sorting-associated protein 21 K07889 RAB5C; Ras-related protein Rab-5C
D KLMA_10609 YPT52; GTP-binding protein YPT52 K07889 RAB5C; Ras-related protein Rab-5C
C Rab associated proteins
D KLMA_20666 VPS9; vacuolar protein sorting-associated protein 9 K20131 RABGEF1; Rab5 GDP/GTP exchange factor
D KLMA_50354 PEP7; vacuolar segregation protein PEP7 K12481 RBSN; rabenosyn-5
D KLMA_50575 VPS34; phosphatidylinositol 3-kinase VPS34 K00914 PIK3C3; phosphatidylinositol 3-kinase [EC:2.7.1.137]
D KLMA_70326 VPS15; serine/threonine-protein kinase VPS15 K08333 PIK3R4; phosphoinositide-3-kinase, regulatory subunit 4 [EC:2.7.11.1]
D KLMA_60344 VPS45; vacuolar protein sorting-associated protein 45 K12479 VPS45; vacuolar protein sorting-associated protein 45
B Arf GTPases and associated proteins
C Arf GTPases
D KLMA_60505 ARF1; ADP-ribosylation factor K07937 ARF1_2; ADP-ribosylation factor 1/2
D KLMA_80220 ARF3; ADP-ribosylation factor 3 K07941 ARF6; ADP-ribosylation factor 6
C Arf associated proteins
D KLMA_40340 AGE2; ADP-ribosylation factor GTPase-activating protein effector protein 2 K12486 SMAP; stromal membrane-associated protein
B Others
C Fucosyltransferase
C EFR3-PI4KIII alpha complex and associated proteins
D KLMA_30314 STT4; phosphatidylinositol 4-kinase STT4 K00888 PI4KA; phosphatidylinositol 4-kinase A [EC:2.7.1.67]
D KLMA_40428 EFR3; protein EFR3 K21842 EFR3; protein EFR3
D KLMA_40256 YPP1; cargo-transport protein YPP1 K21845 YPP1; cargo-transport protein YPP1
C Insulin-like growth factor-binding proteins
C Others
#
AEndosome - Lysosome transport
B Rab GTPases and associated proteins
C Rab GTPases
D KLMA_80212 VPS21; vacuolar protein sorting-associated protein 21 K07889 RAB5C; Ras-related protein Rab-5C
D KLMA_10609 YPT52; GTP-binding protein YPT52 K07889 RAB5C; Ras-related protein Rab-5C
D KLMA_80039 YPT7; GTP-binding protein YPT7 K07897 RAB7A; Ras-related protein Rab-7A
C Retromer subcomplex
D KLMA_50259 VPS35; vacuolar protein sorting-associated protein 35 K18468 VPS35; vacuolar protein sorting-associated protein 35
D KLMA_20560 VPS29; vacuolar protein sorting-associated protein 29 K18467 VPS29; vacuolar protein sorting-associated protein 29
D KLMA_50060 PEP8; vacuolar protein sorting-associated protein 26 K18466 VPS26A_B; vacuolar protein sorting-associated protein 26A/B
C FTS/Hook/FHIP (FHF) complex
C Rab associated proteins
D KLMA_50575 VPS34; phosphatidylinositol 3-kinase VPS34 K00914 PIK3C3; phosphatidylinositol 3-kinase [EC:2.7.1.137]
D KLMA_70322 PRE6; proteasome component PRE6 K02731 PSMA7; 20S proteasome subunit alpha 4 [EC:3.4.25.1]
D KLMA_20097 hypothetical protein K18469 TBC1D5; TBC1 domain family member 5
D KLMA_50603 GYP7; GTPase-activating protein GYP7 K20168 TBC1D15; TBC1 domain family member 15
D KLMA_20828 MRS6; rab proteins geranylgeranyltransferase component A K23460 CHM; Rab proteins geranylgeranyltransferase component A
D KLMA_20695 BET4; protein prenyltransferase K14050 RABGGTA; geranylgeranyl transferase type-2 subunit alpha [EC:2.5.1.60]
D KLMA_20502 BET2; geranylgeranyl transferase type-2 subunit beta K05956 RABGGTB; geranylgeranyl transferase type-2 subunit beta [EC:2.5.1.60]
D KLMA_20611 VPS74; vacuolar protein sorting-associated protein 74 K15620 GOLPH3; golgi phosphoprotein 3
B Arf GTPases and associated proteins
C Arf GTPases
C BLOC-one-related complex (BORC)
C N-acetyl transferase complex C (NatC)
D KLMA_70335 MAK3; N-alpha-acetyltransferase 30 K00670 NAA30; N-alpha-acetyltransferase 30 [EC:2.3.1.256]
D KLMA_30663 MAK10; N-terminal acetyltransferase C complex subunit MAK10 K20823 NAA35; N-alpha-acetyltransferase 35, NatC auxiliary subunit
D KLMA_10551 N-terminal acetyltransferase C complex subunit MAK31 K20824 NAA38; N-alpha-acetyltransferase 38, NatC auxiliary subunit
C Other Arf associated proteins
B Endosomal sorting complexes required for transport (ESCRT)
C ESCRT-0 complex
D KLMA_20419 VPS27; vacuolar protein sorting-associated protein 27 K12182 HGS; hepatocyte growth factor-regulated tyrosine kinase substrate
D KLMA_30064 HSE1; class E vacuolar protein-sorting machinery protein HSE1 K04705 STAM; signal transducing adaptor molecule
C ESCRT-I complex
D KLMA_20476 STP22; suppressor protein STP22 of temperature-sensitive alpha-factor receptor and arginine permease K12183 TSG101; ESCRT-I complex subunit TSG101
D KLMA_10745 VPS28; vacuolar protein sorting-associated protein 28 K12184 VPS28; ESCRT-I complex subunit VPS28
C ESCRT-II complex
D KLMA_70447 SNF8; vacuolar-sorting protein SNF8 K12188 SNF8; ESCRT-II complex subunit VPS22
D KLMA_70084 VPS25; vacuolar protein-sorting-associated protein 25 K12189 VPS25; ESCRT-II complex subunit VPS25
D KLMA_40534 VPS36; vacuolar protein-sorting-associated protein 36 K12190 VPS36; ESCRT-II complex subunit VPS36
C ESCRT-III complex
D KLMA_40233 DID2; vacuolar protein-sorting-associated protein 46 K12197 CHMP1; charged multivesicular body protein 1
D KLMA_30069 DID4; DOA4-independent degradation protein 4 K12191 CHMP2A; charged multivesicular body protein 2A
D KLMA_60305 VPS24; vacuolar protein-sorting-associated protein 24 K12193 VPS24; charged multivesicular body protein 3
D KLMA_40086 SNF7; vacuolar-sorting protein SNF7 K12194 CHMP4A_B; charged multivesicular body protein 4A/B
D KLMA_10162 VPS60; vacuolar protein-sorting-associated protein 60 K12198 CHMP5; charged multivesicular body protein 5
D KLMA_20289 VPS20; vacuolar protein sorting-associated protein 20 K12195 CHMP6; charged multivesicular body protein 6
D KLMA_50055 uncharacterized protein K15053 CHMP7; charged multivesicular body protein 7
D KLMA_70279 VPS4; vacuolar protein sorting-associated protein 4 K12196 VPS4; vacuolar protein-sorting-associated protein 4
C ESCRT associated proteins
D KLMA_10080 VTA1; vacuolar protein sorting-associated protein VTA1 K12199 VTA1; vacuolar protein sorting-associated protein VTA1
D KLMA_40427 RIM20; pH-response regulator protein PalA/RIM20 K12200 PDCD6IP; programmed cell death 6-interacting protein
B Tethering complex
C CORVET complex
D KLMA_80271 VPS3; vacuolar protein sorting-associated protein 3 K20177 VPS3; vacuolar protein sorting-associated protein 3
D KLMA_40027 VPS8; vacuolar protein sorting-associated protein 8 K20178 VPS8; vacuolar protein sorting-associated protein 8
D KLMA_30081 PEP5; vacuolar membrane protein PEP5 K20179 VPS11; vacuolar protein sorting-associated protein 11
D KLMA_60397 VPS16; vacuolar protein sorting-associated protein 16 K20180 VPS16; vacuolar protein sorting-associated protein 16
D KLMA_50524 PEP3; vacuolar membrane protein PEP3 K20181 VPS18; vacuolar protein sorting-associated protein 18
D KLMA_40466 VPS33; vacuolar protein sorting-associated protein 33 K20182 VPS33A; vacuolar protein sorting-associated protein 33A
C Hops complex
D KLMA_30081 PEP5; vacuolar membrane protein PEP5 K20179 VPS11; vacuolar protein sorting-associated protein 11
D KLMA_60397 VPS16; vacuolar protein sorting-associated protein 16 K20180 VPS16; vacuolar protein sorting-associated protein 16
D KLMA_50524 PEP3; vacuolar membrane protein PEP3 K20181 VPS18; vacuolar protein sorting-associated protein 18
D KLMA_40466 VPS33; vacuolar protein sorting-associated protein 33 K20182 VPS33A; vacuolar protein sorting-associated protein 33A
D KLMA_40521 VAM6; vacuolar morphogenesis protein 6 K20183 VPS39; Vam6/Vps39-like protein vacuolar protein sorting-associated protein 39
D KLMA_30373 VPS41; vacuolar protein sorting-associated protein 41 K20184 VPS41; vacuolar protein sorting-associated protein 41
B Acidification regulators
C Rabconnectin-3 complex
D KLMA_10727 RAV1; regulator of V-ATPase in vacuolar membrane protein 1 K24155 DMXL; rabconnectin-3a
C RAVE complex
D KLMA_10727 RAV1; regulator of V-ATPase in vacuolar membrane protein 1 K24155 DMXL; rabconnectin-3a
D KLMA_50584 RAV2; regulator of V-ATPase in vacuolar membrane protein 2 K25485 RAV2; regulator of V-ATPase in vacuolar membrane protein 2
D KLMA_60103 SKP1; suppressor of kinetochore protein 1 K03094 SKP1; S-phase kinase-associated protein 1
B Others
C AP-3 complex
D KLMA_60372 APL5; AP-3 complex subunit delta K12396 AP3D; AP-3 complex subunit delta
D KLMA_10480 APL6; AP-3 complex subunit beta K12397 AP3B; AP-3 complex subunit beta
D KLMA_60342 APM3; AP-3 complex subunit mu K12398 AP3M; AP-3 complex subunit mu
D KLMA_30206 APS3; AP-3 complex subunit sigma K12399 AP3S; AP-3 complex subunit sigma
C BLOC-1 complex
C BLOC-1 complex (yeast)
D KLMA_40520 BLS1; hypothetical protein K22239 BLS1; biogenesis of lysosome-related organelles complex 1 subunit BLS1
D KLMA_20451 CLN1; uncharacterized protein K22240 CNL1; biogenesis of lysosome-related organelles complex 1 subunit CNL1
D KLMA_80205 SNN1; uncharacterized protein K22241 SNN1; biogenesis of lysosome-related organelles complex 1 subunit SNN1
D KLMA_60373 KXD1; uncharacterized protein K22243 KXD1; biogenesis of lysosome-related organelles complex 1 subunit KXD1
C BLOC-2 complex
C BLOC-3 complex
C Ferlins
C Others
D KLMA_20270 MON1; vacuolar fusion protein MON1 K20195 MON1; vacuolar fusion protein MON1
D KLMA_20715 CCZ1; vacuolar fusion protein CCZ1 K21156 CCZ1; vacuolar fusion protein CCZ1, fungi type
D KLMA_20028 DOA4; ubiquitin carboxyl-terminal hydrolase 4 K11839 USP8; ubiquitin carboxyl-terminal hydrolase 8 [EC:3.4.19.12]
D KLMA_30071 VPS1; vacuolar protein sorting-associated protein 1 K23481 VPS1; vacuolar protein sorting-associated protein 1
D KLMA_50266 BPH1; uncharacterized protein K24781 BPH1; beige protein homolog 1
#
AProtein recycling
B Rab GTPases and associated proteins
C Rab GTPases
D KLMA_40632 GTP-binding protein K07905 RAB11B; Ras-related protein Rab-11B
C Rab4 associated proteins
D KLMA_50354 PEP7; vacuolar segregation protein PEP7 K12481 RBSN; rabenosyn-5
D KLMA_30406 SNX4; sorting nexin-4 K17919 SNX4; sorting nexin-4
C Rab11 associated proteins
D KLMA_30094 uncharacterized protein K20241 WDR44; WD repeat-containing protein 44
D KLMA_70250 SEC13; protein transport protein SEC13 K14004 SEC13; protein transport protein SEC13
D KLMA_30694 SEC15; exocyst complex component SEC15 K19985 EXOC6; exocyst complex component 6
D KLMA_50326 GYP5; GTPase-activating protein GYP5 K20242 EVI5; ecotropic viral integration site 5 protein
D KLMA_20611 VPS74; vacuolar protein sorting-associated protein 74 K15620 GOLPH3; golgi phosphoprotein 3
C Other Rab GTPase associated proteins
D KLMA_20666 VPS9; vacuolar protein sorting-associated protein 9 K20131 RABGEF1; Rab5 GDP/GTP exchange factor
D KLMA_80356 RAD51; DNA repair protein RAD51 K04482 RAD51; DNA repair protein RAD51
B Others
C Glutamate receptor-interacting proteins (GRIPs)
C GRIP associated proteins
C EARP complex
D KLMA_10166 VPS52; vacuolar protein sorting-associated protein 52 K20298 VPS52; vacuolar protein sorting-associated protein 52
D KLMA_20698 VPS53; hypothetical protein K20299 VPS53; vacuolar protein sorting-associated protein 53
C WASH complex
D KLMA_30065 CAP1; F-actin-capping protein subunit alpha K10364 CAPZA; F-actin-capping protein subunit alpha
D KLMA_20526 CAP2; F-actin-capping protein subunit beta K10365 CAPZB; F-actin-capping protein subunit beta
C Retriever complex
D KLMA_20560 VPS29; vacuolar protein sorting-associated protein 29 K18467 VPS29; vacuolar protein sorting-associated protein 29
C Others
#
AEndosome - Golgi transport
B Rab GTPases and associated proteins
C Rab GTPases
D KLMA_40193 YPT6; GTP-binding protein YPT6 K07893 RAB6A; Ras-related protein Rab-6A
C Rab associated proteins
D KLMA_20611 VPS74; vacuolar protein sorting-associated protein 74 K15620 GOLPH3; golgi phosphoprotein 3
D KLMA_50442 MDR1; GTPase-activating protein GYP2 K19951 TBC1D8_9; TBC1 domain family member 8/9
D KLMA_40501 SGM1; protein SGM1 K20286 TMF1; TATA element modulatory factor
D KLMA_30462 NIP100; protein NIP100 K04648 DCTN1; dynactin 1
D KLMA_80407 VPS13; vacuolar protein sorting-associated protein 13 K19525 VPS13A_C; vacuolar protein sorting-associated protein 13A/C
B Arf GTPases and associated proteins
C Arf GTPases
D KLMA_60505 ARF1; ADP-ribosylation factor K07937 ARF1_2; ADP-ribosylation factor 1/2
D KLMA_10821 ARL1; ADP-ribosylation factor-like protein 1 K07942 ARL1; ADP-ribosylation factor-like protein 1
D KLMA_70376 ARL3; ADP-ribosylation factor-like protein 3 K07952 ARFRP1; ADP-ribosylation factor related protein 1
C Arf GTPase associated proteins
D KLMA_50588 GCS1; ADP-ribosylation factor GTPase-activating protein GCS1 K12492 ARFGAP1; ADP-ribosylation factor GTPase-activating protein 1
D KLMA_70147 GLO3; ADP-ribosylation factor GTPase-activating protein GLO3 K12493 ARFGAP2_3; ADP-ribosylation factor GTPase-activating protein 2/3
D KLMA_40340 AGE2; ADP-ribosylation factor GTPase-activating protein effector protein 2 K12486 SMAP; stromal membrane-associated protein
D KLMA_50534 SEC7; protein transport protein SEC7 K18442 ARFGEF; brefeldin A-inhibited guanine nucleotide-exchange protein
D KLMA_10729 GEA2; ARF guanine-nucleotide exchange factor 2 K18443 GBF1; golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1
B Tethering complex
C Conserved oligomeric Golgi (COG) complex
D KLMA_30374 COG3; conserved oligomeric Golgi complex subunit 3 K20290 COG3; conserved oligomeric Golgi complex subunit 3
D KLMA_20342 COG4; conserved oligomeric Golgi complex subunit 4 K20291 COG4; conserved oligomeric Golgi complex subunit 4
D KLMA_80144 COG6; conserved oligomeric Golgi complex subunit 6 K20293 COG6; conserved oligomeric Golgi complex subunit 6
D KLMA_40441 COG8; conserved oligomeric Golgi complex component K20295 COG8; conserved oligomeric Golgi complex subunit 8
C GARP complex
D KLMA_10602 vacuolar protein sorting-associated protein 51 K20297 VPS51; vacuolar protein sorting-associated protein 51
D KLMA_10166 VPS52; vacuolar protein sorting-associated protein 52 K20298 VPS52; vacuolar protein sorting-associated protein 52
D KLMA_20698 VPS53; hypothetical protein K20299 VPS53; vacuolar protein sorting-associated protein 53
D KLMA_60547 VPS54; vacuolar protein sorting-associated protein 54 K17600 VPS54; vacuolar protein sorting-associated protein 54
C TRAPP complex II
D KLMA_40448 BET5; transport protein particle 18 kDa subunit K20300 TRAPPC1; trafficking protein particle complex subunit 1
D KLMA_50462 TRS20; transport protein particle 20 kDa subunit K20301 TRAPPC2; trafficking protein particle complex subunit 2
D KLMA_30248 BET3; transport protein particle 22 kDa subunit K20302 TRAPPC3; trafficking protein particle complex subunit 3
D KLMA_60380 TRS23; transport protein particle 23 kDa subunit K20303 TRAPPC4; trafficking protein particle complex subunit 4
D KLMA_20562 TRS31; transport protein particle 31 kDa subunit K20280 TRAPPC5; trafficking protein particle complex subunit 5
D KLMA_60239 TRS33; transport protein particle 33 kDa subunit K20304 TRAPPC6; trafficking protein particle complex subunit 6
D KLMA_40130 TRS85; transport protein particle 85 kDa subunit K20305 TRAPPC8; trafficking protein particle complex subunit 8
D KLMA_30648 TRS120; transport protein particle complex II subunit K20306 TRAPPC9; trafficking protein particle complex subunit 9
D KLMA_10315 TRS130; transport protein particle complex II subunit K20307 TRAPPC10; trafficking protein particle complex subunit 10
D KLMA_30181 beta-glucan synthesis-associated protein KRE11 K20311 TRS65; trafficking protein particle complex II-specific subunit 65
D KLMA_30273 TRAPP-associated protein TCA17 K20312 TCA17; TRAPP-associated protein TCA17
B Others
C AP-1 complex
D KLMA_70137 APL4; AP-1 complex subunit gamma-1 K12391 AP1G1; AP-1 complex subunit gamma-1
D KLMA_30117 APL2; AP-1 complex subunit beta-1 K12392 AP1B1; AP-1 complex subunit beta-1
D KLMA_50404 APM1; AP-1 complex subunit mu-1-I K12393 AP1M; AP-1 complex subunit mu
D KLMA_60308 APM2; AP-1 complex subunit mu-1 K12393 AP1M; AP-1 complex subunit mu
D KLMA_40289 APS1; AP-1 complex subunit sigma-1 K12394 AP1S1_2; AP-1 complex subunit sigma 1/2
C AP-3 complex
D KLMA_60372 APL5; AP-3 complex subunit delta K12396 AP3D; AP-3 complex subunit delta
D KLMA_10480 APL6; AP-3 complex subunit beta K12397 AP3B; AP-3 complex subunit beta
D KLMA_60342 APM3; AP-3 complex subunit mu K12398 AP3M; AP-3 complex subunit mu
D KLMA_30206 APS3; AP-3 complex subunit sigma K12399 AP3S; AP-3 complex subunit sigma
C AP-4 complex
C GGA
D KLMA_20450 GGA2; ADP-ribosylation factor-binding protein GGA2 K12404 GGA; ADP-ribosylation factor-binding protein GGA
C Aftiphilin/p200/gamma-synergin complex
D KLMA_10144 LAA1; hypothetical protein K24814 HEATR5; HEAT repeat-containing protein 5
C Others
D KLMA_40231 SPO14; phospholipase D1 K01115 PLD1_2; phospholipase D1/2 [EC:3.1.4.4]
D KLMA_30314 STT4; phosphatidylinositol 4-kinase STT4 K00888 PI4KA; phosphatidylinositol 4-kinase A [EC:2.7.1.67]
D KLMA_50129 MSS4; probable phosphatidylinositol-4-phosphate 5-kinase MSS4 K00889 PIP5K; 1-phosphatidylinositol-4-phosphate 5-kinase [EC:2.7.1.68]
D KLMA_20473 FAB1; 1-phosphatidylinositol-3-phosphate 5-kinase FAB1 K00921 PIKFYVE; 1-phosphatidylinositol-3-phosphate 5-kinase [EC:2.7.1.150]
D KLMA_30228 SYS1; protein SYS1 K20318 SYS1; protein SYS1
D KLMA_10774 GDT1; uncharacterized protein K23541 TMEM165; Ca2+/H+ antiporter, TMEM165/GDT1 family
D KLMA_30091 VPH2; vacuolar ATPase assembly integral membrane protein VPH2 K23542 TMEM199; TMEM199 family protein
D KLMA_30541 VMA22; vacuolar ATPase assembly protein VMA22 K23543 CCDC115; coiled-coil domain-containing protein 115
D KLMA_20175 TMS1; membrane protein TMS1 K23544 SERINC1; serine incorporator 1
D KLMA_30584 SNX3; sorting nexin-3 K17918 SNX3_12; sorting nexin-3/12
D KLMA_10263 MVP1; sorting nexin MVP1 K17922 SNX8; sorting nexin-8
D KLMA_20131 Golgi apparatus membrane protein TVP15 K26750 TVP15; golgi apparatus membrane protein TVP15
D KLMA_60331 TVP18; Golgi apparatus membrane protein TVP18 K26751 TVP18; golgi apparatus membrane protein TVP18
D KLMA_60203 TVP23; Golgi apparatus membrane protein TVP23 K26752 TVP23; golgi apparatus membrane protein TVP23
D KLMA_10406 TVP38; Golgi apparatus membrane protein TVP38 K26753 TVP38; golgi apparatus membrane protein TVP38
D KLMA_30071 VPS1; vacuolar protein sorting-associated protein 1 K23481 VPS1; vacuolar protein sorting-associated protein 1
#
AEndoplasmic reticulum (ER) - Golgi transport
B Forward pathways
C Coat protein complex II (COP-II)
D KLMA_40556 SAR1; small COPII coat GTPase SAR1 K07953 SAR1; GTP-binding protein SAR1 [EC:3.6.5.-]
D KLMA_70250 SEC13; protein transport protein SEC13 K14004 SEC13; protein transport protein SEC13
D KLMA_60508 SEC31; protein transport protein SEC31 K14005 SEC31; protein transport protein SEC31
D KLMA_20498 SEC23; protein transport protein SEC23 K14006 SEC23; protein transport protein SEC23
D KLMA_80155 SEC24; protein transport protein SEC24 K14007 SEC24; protein transport protein SEC24
D KLMA_40263 SFB3; SED5-binding protein 3 K14007 SEC24; protein transport protein SEC24
D KLMA_30502 SEC12; putative guanine nucleotide-exchange factor SED4 K14003 PREB; prolactin regulatory element-binding protein
D KLMA_10779 SEC16; hypothetical protein K20353 SEC16; COPII coat assembly protein SEC16
C TRAPP complex I
D KLMA_40448 BET5; transport protein particle 18 kDa subunit K20300 TRAPPC1; trafficking protein particle complex subunit 1
D KLMA_50462 TRS20; transport protein particle 20 kDa subunit K20301 TRAPPC2; trafficking protein particle complex subunit 2
D KLMA_30248 BET3; transport protein particle 22 kDa subunit K20302 TRAPPC3; trafficking protein particle complex subunit 3
D KLMA_60380 TRS23; transport protein particle 23 kDa subunit K20303 TRAPPC4; trafficking protein particle complex subunit 4
D KLMA_20562 TRS31; transport protein particle 31 kDa subunit K20280 TRAPPC5; trafficking protein particle complex subunit 5
D KLMA_60239 TRS33; transport protein particle 33 kDa subunit K20304 TRAPPC6; trafficking protein particle complex subunit 6
C p24 family proteins
D KLMA_10448 ERP1; protein ERP1 K20346 TMED4_9_11; p24 family protein alpha
D KLMA_20446 ERP5; protein ERP5 K20346 TMED4_9_11; p24 family protein alpha
D KLMA_30141 EMP24; endosomal protein P24B K20347 TMED2; p24 family protein beta-1
D KLMA_50417 ERP4; protein ERP4 K14825 TMED5; p24 family protein gamma-2
D KLMA_40604 ERV25; endoplasmic reticulum vesicle protein 25 K20352 TMED10; p24 family protein delta-1
C PDI family proteins
D KLMA_10049 PDI1; protein disulfide-isomerase K09580 PDIA1; protein disulfide-isomerase A1 [EC:5.3.4.1]
D KLMA_10614 MPD1; protein disulfide isomerase MPD1 family protein K09584 PDIA6; protein disulfide-isomerase A6 [EC:5.3.4.1]
C Rab GTPases
D KLMA_70054 YPT1; GTP-binding protein YPT1 K07874 RAB1A; Ras-related protein Rab-1A
C Rab associated proteins
D KLMA_80148 YIP3; prenylated Rab acceptor 1 K20359 RABAC1; PRA1 family protein 1
D KLMA_20311 GYP8; GTPase-activating protein GYP8 K20372 TBC1D20; TBC1 domain family member 20
D KLMA_10116 YIF1; protein transport protein YIF1 K20362 YIF1; protein transport protein YIF1
D KLMA_70075 USO1; intracellular protein transport protein USO1 K20361 USO1; intracellular protein transport protein USO1
C ER-Golgi intermediate compartment (ERGIC) proteins
D KLMA_70027 EMP47; protein EMP47 K10080 LMAN1; lectin, mannose-binding 1
D KLMA_20306 MNL2; uncharacterized protein K01230 MAN1A_C; mannosyl-oligosaccharide alpha-1,2-mannosidase [EC:3.2.1.113]
D KLMA_40509 MNS1; endoplasmic reticulum mannosyl-oligosaccharide 1 K23741 MAN1B; endoplasmic reticulum Man9GlcNAc2 1,2-alpha-mannosidase [EC:3.2.1.209]
D KLMA_50165 ERV41; ER-derived vesicles protein ERV41 K20366 ERGIC2; endoplasmic reticulum-Golgi intermediate compartment protein 2
D KLMA_80245 ERV46; ER-derived vesicles protein ERV46 K20367 ERGIC3; endoplasmic reticulum-Golgi intermediate compartment protein 3
D KLMA_10240 ERV14; ER-derived vesicles protein ERV14 K20368 CNIH; protein cornichon
D KLMA_80182 ERV29; ER-derived vesicles protein ERV29 K20369 ERV29; ER-derived vesicles protein
D KLMA_20691 GRP78; uncharacterized protein K09490 HSPA5; endoplasmic reticulum chaperone BiP [EC:3.6.4.10]
B Retrieval pathways
C Coat protein complex I (COP-I)
D KLMA_60523 COP1; coatomer subunit alpha K05236 COPA; coatomer subunit alpha
D KLMA_30519 SEC26; coatomer subunit beta K17301 COPB1; coatomer subunit beta
D KLMA_40560 SEC27; coatomer subunit beta' K17302 COPB2; coatomer subunit beta'
D KLMA_70400 SEC21; coatomer subunit gamma K17267 COPG; coatomer subunit gamma
D KLMA_60410 RET2; coatomer subunit delta K20471 COPD; coatomer subunit delta
D KLMA_30484 SEC28; coatomer subunit epsilon K17268 COPE; coatomer subunit epsilon
D KLMA_40330 RET3; coatomer subunit zeta K20472 COPZ; coatomer subunit zeta
C NRZ (DSL1) complex
D KLMA_60015 TIP20; protein transport protein TIP20 K20474 RINT1; RAD50-interacting protein 1
D KLMA_10122 DSL1; protein transport protein DSL1 K11578 ZW10; protein transport protein DSL1/ZW10
D KLMA_50172 SEC39; protein transport protein SEC39 K20475 SEC39; protein transport protein SEC39
C Golgi to ER traffic proteins (GET)
D KLMA_50145 GET1; Golgi to ER traffic protein 1 K22384 GET1; tail-anchored protein insertion receptor
D KLMA_30483 GET2; Golgi to ER traffic protein 2 K22386 GET2; GET complex subunit GET2
D KLMA_20650 GET3; ATPase GET3 K01551 arsA; arsenite/tail-anchored protein-transporting ATPase [EC:7.3.2.7 7.3.-.-]
D KLMA_40185 GET4; uncharacterized protein K23387 GET4; golgi to ER traffic protein 4
C Rab GTPases
D KLMA_40193 YPT6; GTP-binding protein YPT6 K07893 RAB6A; Ras-related protein Rab-6A
C Rab associated proteins
D KLMA_40065 RIC1; protein RIC1 K20476 RIC1; RAB6A-GEF complex partner protein 1
D KLMA_20189 RGP1; reduced growth phenotype protein 1 K20477 RGP1; RAB6A-GEF complex partner protein 2
D KLMA_70091 ERD2; ER lumen protein retaining receptor K10949 KDELR; ER lumen protein retaining receptor
D KLMA_50354 PEP7; vacuolar segregation protein PEP7 K12481 RBSN; rabenosyn-5
B Others
C Oxysterol-binding proteins
D KLMA_10185 OSH2; uncharacterized protein K20456 OSBP; oxysterol-binding protein 1
D KLMA_70257 OSH3; uncharacterized protein K20463 OSBPL3_6_7; oxysterol-binding protein-related protein 3/6/7
D KLMA_30626 OSH7; uncharacterized protein K22285 OSBPL8; oxysterol-binding protein-related protein 8
D KLMA_20778 KES1; protein KES1 K20465 OSBPL9_10_11; oxysterol-binding protein-related protein 9/10/11
C FXYD proteins
C YIPF proteins
D KLMA_30613 YPT-interacting protein K22940 YIPF1_2; protein YIPF1/2
D KLMA_30198 YIP1; protein transport protein YIP1 K20363 YIPF5_7; protein YIPF5/7
D KLMA_30143 YIP4; protein YIP4 K22943 YIPF6; protein YIPF6
C ER membrane protein complex
D KLMA_10047 EMC1; DUF1620 super family K23562 EMC1; ER membrane protein complex subunit 1
D KLMA_70115 EMC2; ER membrane protein complex subunit 2 K23563 EMC2; ER membrane protein complex subunit 2
D KLMA_30038 AIM27; ER membrane protein complex subunit 3 K23564 EMC3; ER membrane protein complex subunit 3
D KLMA_30692 EMC4; ER membrane protein complex subunit 4 K23565 EMC4; ER membrane protein complex subunit 4
D KLMA_40349 EMC5; ER membrane protein complex subunit 5 K23566 MMGT1; membrane magnesium transporter 1
D KLMA_30216 uncharacterized protein K23567 EMC6; ER membrane protein complex subunit 6
C SEC61 complex
D KLMA_50087 SSH1; uncharacterized protein K10956 SEC61A; protein transport protein SEC61 subunit alpha
D KLMA_20424 SEC61; protein transport protein SEC61 subunit alpha K10956 SEC61A; protein transport protein SEC61 subunit alpha
D KLMA_80337 SBH1; protein transport protein Sec61 subunit beta K09481 SEC61B; protein transport protein SEC61 subunit beta
D KLMA_60198 protein transport protein SSS1 K07342 SEC61G; protein transport protein SEC61 subunit gamma and related proteins
C TRAP complex
C Multi-pass translocon (MPT) complex
D KLMA_30488 uncharacterized protein K24962 CCDC47; PAT complex subunit CCDC47
C Post-GPI attachment to proteins factors (PGAP)
D KLMA_60296 BST1; GPI inositol-deacylase K05294 PGAP1; GPI inositol-deacylase [EC:3.-.-.-]
D KLMA_10094 PER1; protein PER1 K23553 PGAP3; post-GPI attachment to proteins factor 3
D KLMA_50556 CDC1; cell division control protein 1 K23362 MPPE1; ethanolamine phosphate phosphodiesterase [EC:3.1.-.-]
D KLMA_20518 TED1; protein TED1 K23362 MPPE1; ethanolamine phosphate phosphodiesterase [EC:3.1.-.-]
C Others
D KLMA_50568 SLY1; protein SLY1 K19998 SCFD1; sec1 family domain-containing protein 1
D KLMA_20457 POM33; uncharacterized protein K20724 TMEM33; transmembrane protein 33
D KLMA_70055 PER33; uncharacterized protein K20724 TMEM33; transmembrane protein 33
D KLMA_50573 ARV1; protein ARV1 K21848 ARV1; lipid intermediate transporter
D KLMA_30691 KEG1; uncharacterized protein K21849 KEG1; beta-1,6-glucan synthesis-associated protein KEG1
D KLMA_20549 KRE6; beta-glucan synthesis-associated protein KRE6 K21850 KRE6; beta-glucan synthesis-associated protein KRE6
D KLMA_20611 VPS74; vacuolar protein sorting-associated protein 74 K15620 GOLPH3; golgi phosphoprotein 3
D KLMA_40354 NSG2; protein NSG2 K26681 INSIG; insulin-induced protein
D KLMA_40186 SEY1; protein SEY1 K22698 SEY1; protein SEY1 [EC:3.6.5.-]
#
AAutophagy
B Autophagosome formation proteins
C ULK complex
D KLMA_40473 ATG13; autophagy-related protein 13 K08331 ATG13; autophagy-related protein 13
C Atg1 complex
D KLMA_30321 ATG1; serine/threonine-protein kinase ATG1 K08269 ULK2; serine/threonine-protein kinase ULK2 [EC:2.7.11.1]
D KLMA_40473 ATG13; autophagy-related protein 13 K08331 ATG13; autophagy-related protein 13
D KLMA_10625 ATG17; autophagy-related protein 17 K08329 ATG17; autophagy-related protein 17
D KLMA_30451 ATG29; autophagy-related protein 29 K21143 ATG29; autophagy-related protein 29
C PI3K complex
D KLMA_50575 VPS34; phosphatidylinositol 3-kinase VPS34 K00914 PIK3C3; phosphatidylinositol 3-kinase [EC:2.7.1.137]
D KLMA_70326 VPS15; serine/threonine-protein kinase VPS15 K08333 PIK3R4; phosphoinositide-3-kinase, regulatory subunit 4 [EC:2.7.11.1]
D KLMA_20709 ATG14; autophagy-related protein 14 K08335 ATG14; autophagy-related protein 14
D KLMA_50047 VPS30; vacuolar protein sorting-associated protein 30 K08334 BECN; beclin
D KLMA_70233 uncharacterized protein K21145 ATG38; autophagy-related protein 38
C ATG9 transmembrane protein
D KLMA_70236 ATG9; autophagy-related protein 9 K17907 ATG9; autophagy-related protein 9
C Atg18-Atg2 complex
D KLMA_20474 ATG18; autophagy-related protein 18 K17908 WIPI1_2; autophagy-related protein 18
D KLMA_10800 ATG21; autophagy-related protein 21 K17908 WIPI1_2; autophagy-related protein 18
D KLMA_50633 ATG2; autophagy-related protein 2 K17906 ATG2; autophagy-related protein 2
C Atg12 conjugation proteins
D KLMA_10251 ATG12; autophagy-related protein 12 K08336 ATG12; ubiquitin-like protein ATG12
D KLMA_40433 ATG7; autophagy-related protein 7 K08337 ATG7; ubiquitin-like modifier-activating enzyme ATG7
D KLMA_80409 ATG10; autophagy-related protein 10 K08338 ATG10; ubiquitin-like-conjugating enzyme ATG10
D KLMA_20199 ATG5; autophagy protein 5 K08339 ATG5; autophagy-related protein 5
D KLMA_20649 ATG16; autophagy protein 16 K08340 ATG16; autophagy-related protein 16
C Atg8 conjugation proteins
D KLMA_80372 ATG8; autophagy-related protein 8 K08341 GABARAP; GABA(A) receptor-associated protein
D KLMA_50615 ATG4; probable cysteine protease ATG4 K08342 ATG4; cysteine protease ATG4 [EC:3.4.22.-]
D KLMA_40433 ATG7; autophagy-related protein 7 K08337 ATG7; ubiquitin-like modifier-activating enzyme ATG7
D KLMA_60454 ATG3; autophagy-related protein 3 K08343 ATG3; ubiquitin-like-conjugating enzyme ATG3
B Cytoplasm to vacuolar targeting (CVT) pathway
C Selective cargos
D KLMA_20156 LAP4; vacuolar aminopeptidase 1 K01268 LAP4; aminopeptidase I [EC:3.4.11.22]
D KLMA_80405 APE4; putative aspartyl aminopeptidase K01267 DNPEP; aspartyl aminopeptidase [EC:3.4.11.21]
C Cargo receptors
C Scaffold protein
D KLMA_70337 ATG11; autophagy-related protein 11 K08330 ATG11; autophagy-related protein 11
C Other Cvt associated proteins
D KLMA_40610 SNX41; sorting nexin-41 K21996 SNX41_42; sorting nexin-41/42
D KLMA_80093 ATG20; autophagy-related protein 20 K21996 SNX41_42; sorting nexin-41/42
D KLMA_30406 SNX4; sorting nexin-4 K17919 SNX4; sorting nexin-4
D KLMA_30505 ATG15; putative lipase ATG15 K17900 ATG15; lipase ATG15 [EC:3.1.1.3]
D KLMA_50185 ATG23; autophagy-related protein 23 K17909 ATG23; autophagy-related protein 23
D KLMA_10375 ATG27; autophagy-related protein 27 K21141 ATG27; autophagy-related protein 27
D KLMA_10553 VAC8; vacuolar protein 8 K08332 VAC8; vacuolar protein 8
B Mitophagy
C Cargo receptors
D KLMA_30710 ATG32; protein ECM37 K17984 ATG32; autophagy-related protein 32
C Scaffold proteins
D KLMA_70337 ATG11; autophagy-related protein 11 K08330 ATG11; autophagy-related protein 11
C PINK1-Parkin associated proteins
D KLMA_10794 FZO1; transmembrane GTPase FZO1 K06030 MFN2; mitofusin 2 [EC:3.6.5.-]
C Other mitophagy associated proteins
D KLMA_10051 GLK1; glucokinase-1 K00844 HK; hexokinase [EC:2.7.1.1]
D KLMA_60412 RAG5; hexokinase K00844 HK; hexokinase [EC:2.7.1.1]
D KLMA_60492 ATPase inhibitor K22255 ATPIF1; ATPase inhibitor, mitochondrial
D KLMA_60530 mitochondrial import receptor subunit TOM7 K17771 TOM7; mitochondrial import receptor subunit TOM7
D KLMA_30630 conserved hypothetical membrane protein K19717 ATG33; autophagy-related protein 33
B Pexophagy
C Selective cargos
D KLMA_60104 PEX3; peroxisomal biogenesis factor 3 K13336 PEX3; peroxin-3
D KLMA_80104 PEX14; peroxisomal membrane protein PEX14 K13343 PEX14; peroxin-14
C Cargo receptors
C Other pexophagy associated proteins
D KLMA_50223 PEX1; peroxisomal ATPase PEX1 K13338 PEX1; peroxin-1
D KLMA_20627 PEX6; peroxisomal biogenesis factor 6 K13339 PEX6; peroxin-6
D KLMA_20365 hypothetical protein K22260 PEX15; peroxin-15
B Aggrephagy
C Cargo receptors
C Scaffold proteins
C Other aggrephagy associated proteins
D KLMA_60484 CDC48; cell division control protein 48 K13525 VCP; transitional endoplasmic reticulum ATPase
D KLMA_80132 HDA1; histone deacetylase HDA1 K11407 HDAC6; histone deacetylase 6 [EC:3.5.1.98]
B Xenophagy
C Cargo receptors
C Other xenophagy associated proteins
B Chaperone mediated autophagy (CMA)
C Selective cargos
D KLMA_40083 AAT2; aspartate aminotransferase K14454 GOT1; aspartate aminotransferase, cytoplasmic [EC:2.6.1.1]
D KLMA_20296 GPD2; glyceraldehyde-3-phosphate dehydrogenase 2 K00134 GAPDH; glyceraldehyde 3-phosphate dehydrogenase (phosphorylating) [EC:1.2.1.12]
D KLMA_40218 GAP1; glyceraldehyde-3-phosphate dehydrogenase 1 K00134 GAPDH; glyceraldehyde 3-phosphate dehydrogenase (phosphorylating) [EC:1.2.1.12]
D KLMA_80059 GAP3; glyceraldehyde-3-phosphate dehydrogenase 3 K00134 GAPDH; glyceraldehyde 3-phosphate dehydrogenase (phosphorylating) [EC:1.2.1.12]
D KLMA_10182 GPM3; phosphoglycerate mutase 3 K01834 PGAM; 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase [EC:5.4.2.11]
D KLMA_20098 GPM1; phosphoglycerate mutase 1 K01834 PGAM; 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase [EC:5.4.2.11]
D KLMA_60219 PYK1; pyruvate kinase K00873 PK; pyruvate kinase [EC:2.7.1.40]
D KLMA_10585 DSK2; ubiquitin domain-containing protein DSK2 K04523 UBQLN; ubiquilin
C Cargo receptors
C Chaperones
D KLMA_20459 SSA2; heat shock protein SSA2 K03283 HSPA1_6_8; heat shock 70kDa protein 1/6/8
D KLMA_80367 SSA3; heat shock protein SSA3 K03283 HSPA1_6_8; heat shock 70kDa protein 1/6/8
D KLMA_50592 SSB; heat shock protein SSB K03283 HSPA1_6_8; heat shock 70kDa protein 1/6/8
D KLMA_50344 HSP82; ATP-dependent molecular chaperone HSC82 K04079 HSP90A; molecular chaperone HtpG
C Co-chaperones
C Other CMA associated proteins
D KLMA_80309 TEF; elongation factor 1-alpha K03231 EEF1A; elongation factor 1-alpha
D KLMA_60138 uncharacterized protein K13289 CTSA; cathepsin A (carboxypeptidase C) [EC:3.4.16.5]
D KLMA_10499 PRC1; carboxypeptidase Y K13289 CTSA; cathepsin A (carboxypeptidase C) [EC:3.4.16.5]
B Other autophagy associated proteins
C RNautophagy/DNautophagy
C Micronucleophagy
D KLMA_10553 VAC8; vacuolar protein 8 K08332 VAC8; vacuolar protein 8
C Midbophagy
C Glycophagy
C TRIM-directed selective autophagy
C ER-mitochondria tethering complex
D KLMA_10794 FZO1; transmembrane GTPase FZO1 K06030 MFN2; mitofusin 2 [EC:3.6.5.-]
C mTORC1 complex
D KLMA_30046 TOR2; serine/threonine-protein kinase TOR2 K07203 MTOR; serine/threonine-protein kinase mTOR [EC:2.7.11.1]
D KLMA_20480 LST8; target of rapamycin complex subunit LST8 K08266 MLST8; target of rapamycin complex subunit LST8
D KLMA_10476 KOG1; target of rapamycin complex 1 subunit KOG1 K07204 RAPTOR; regulatory associated protein of mTOR
D KLMA_60345 TCO89; target of rapamycin complex 1 subunit TCO89 K25579 TCO89; target of rapamycin complex 1 subunit TCO89
C mTORC2 complex
D KLMA_30046 TOR2; serine/threonine-protein kinase TOR2 K07203 MTOR; serine/threonine-protein kinase mTOR [EC:2.7.11.1]
D KLMA_20480 LST8; target of rapamycin complex subunit LST8 K08266 MLST8; target of rapamycin complex subunit LST8
D KLMA_60139 AVO1; target of rapamycin complex 2 subunit AVO1 K20410 MAPKAP1; target of rapamycin complex 2 subunit MAPKAP1/AVO1
D KLMA_80350 TSC11; target of rapamycin complex 2 subunit TSC11 K08267 RICTOR; rapamycin-insensitive companion of mTOR
D KLMA_60169 AVO2; hypothetical protein K25576 AVO2; target of rapamycin complex 2 subunit AVO2
D KLMA_50064 BIT61; HbrB domain family protein K25577 BIT61_2; target of rapamycin complex 2 subunit BIT61/BIT2
C SEACIT/GATOR1 complex
D KLMA_40492 IML1; vacuolar membrane-associated protein IML1 K20404 DEPDC5; SEA/GATOR complex protein SEA1/DEPDC5
D KLMA_80032 NPR2; nitrogen permease regulator 2 K20405 NPRL2; nitrogen permease regulator 2
D KLMA_40101 NPR3; protein RMD11 K20406 NPRL3; nitrogen permease regulator 3
C SEACAT/GATOR2 complex
D KLMA_80390 RTC1; uncharacterized protein K20408 WDR24; SEA/GATOR complex protein SEA2/WDR24
D KLMA_40162 MTC5; uncharacterized protein K20409 WDR59; SEA/GATOR complex protein SEA3/WDR59
D KLMA_70131 SEA4; uncharacterized protein K20407 MIOS; SEA/GATOR complex protein SEA4/MIOS
D KLMA_20406 SEH1; nucleoporin SEH1 K14299 SEH1; nucleoporin SEH1
D KLMA_70250 SEC13; protein transport protein SEC13 K14004 SEC13; protein transport protein SEC13
C KICSTOR complex
C Rab GTPases
D KLMA_70054 YPT1; GTP-binding protein YPT1 K07874 RAB1A; Ras-related protein Rab-1A
D KLMA_30127 SEC4; ras-related protein SEC4 K07901 RAB8A; Ras-related protein Rab-8A
C Rab associated proteins
C Others
D KLMA_60499 PPH21; serine/threonine-protein phosphatase PP2A-1 catalytic subunit K04382 PPP2C; serine/threonine-protein phosphatase 2A catalytic subunit [EC:3.1.3.16]
D KLMA_80253 TAP42; type 2A phosphatase-associated protein 42 K17606 IGBP1; immunoglobulin-binding protein 1
D KLMA_10053 ATG22; autophagy-related protein 22 K06902 UMF1; MFS transporter, UMF1 family
D KLMA_80233 AVT4; vacuolar amino acid transporter 4 K14209 SLC36A; solute carrier family 36 (proton-coupled amino acid transporter)
D KLMA_70424 AVT3; vacuolar amino acid transporter 3 K14209 SLC36A; solute carrier family 36 (proton-coupled amino acid transporter)
D KLMA_60059 HSV2; SVP1-like protein 2 K22991 WDR45; WD repeat-containing protein 45
D KLMA_50447 VMA21; vacuolar ATPase assembly integral membrane protein VMA21 K23952 VMA21; vacuolar ATPase assembly integral membrane protein VMA21
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AOthers
B NADPH oxidases (Nox) and associated proteins
C NADPH oxidases
C Nox associated proteins
B Actin-binding proteins
C Myosins
D KLMA_30106 MYO1; myosin-1 K10356 MYO1; myosin I
D KLMA_50113 MYO2; myosin-2 K10357 MYO5; myosin V
C Arp2/3 complex
D KLMA_20232 ARC40; actin-related protein 2/3 complex subunit 1 K05757 ARPC1A_B; actin related protein 2/3 complex, subunit 1A/1B
D KLMA_20394 ARC35; actin-related protein 2/3 complex subunit 2 K05758 ARPC2; actin related protein 2/3 complex, subunit 2
D KLMA_50273 ARC18; actin-related protein 2/3 complex subunit 3 K05756 ARPC3; actin related protein 2/3 complex, subunit 3
D KLMA_60156 ARC19; actin-related protein 2/3 complex subunit 4 K05755 ARPC4; actin related protein 2/3 complex, subunit 4
D KLMA_70174 ARC15; actin-related protein 2/3 complex subunit 5 K05754 ARPC5; actin related protein 2/3 complex, subunit 5
D KLMA_10173 ARP2; actin-related protein 2 K17260 ACTR2; actin-related protein 2
D KLMA_30048 ARP3; actin-related protein 3 K18584 ACTR3; actin-related protein 3
C Nucleation-promoting factors (NPFs)
D KLMA_10217 LAS17; proline-rich protein LAS17 K23612 WASL; neural Wiskott-Aldrich syndrome protein
D KLMA_20250 ABP1; actin-binding protein K20520 DBNL; drebrin-like protein
D KLMA_50368 PAN1; actin cytoskeleton-regulatory complex protein PAN1 K20047 PAN1; actin cytoskeleton-regulatory complex protein PAN1
D KLMA_20579 RVS167; uncharacterized protein K12562 AMPH; amphiphysin
D KLMA_50160 BAR super family and SH3 K12562 AMPH; amphiphysin
D KLMA_50155 SLA1; actin cytoskeleton-regulatory complex protein SLA1 K20046 SLA1; actin cytoskeleton-regulatory complex protein SLA1
D KLMA_30178 BBC1; myosin tail region-interacting protein MTI1 K20521 BBC1; myosin tail region-interacting protein MTI1
D KLMA_20542 PIN3; [PSI+] inducibility protein 3 K20522 LSB1_2; LAS seventeen-binding protein 1/2
D KLMA_10431 LSB3; DUF500 super family K20523 SH3YL1; SH3 domain-containing YSC84-like protein 1
D KLMA_10059 LSB5; LAS seventeen-binding protein 5 K20524 LSB5; LAS seventeen-binding protein 5
D KLMA_30155 LSB6; phosphatidylinositol 4-kinase LSB6 K13711 PI4K2; phosphatidylinositol 4-kinase type 2 [EC:2.7.1.67]
C Others
D KLMA_20614 PFY1; profilin K05759 PFN; profilin
D KLMA_80417 COF1; actin-depolymerizing factor 1 K05765 CFL; cofilin
D KLMA_10572 SRV2; adenylyl cyclase-associated protein K17261 CAP1_2; adenylyl cyclase-associated protein
D KLMA_20824 SCP1; transgelin K20526 TAGLN; transgelin
B Mucins
C Membrane bound mucins
C Secretory mucins
B Specific organelles associated proteins
C Melanosome
C Auto phagosome
C Lipid droplets
C Mitochondrion
B Rho GTPase associated proteins
C Rho GTPase-activating proteins
D KLMA_50090 RGD1; RHO GTPase-activating protein RGD1 K20643 RGD1; Rho GTPase-activating protein RGD1
C Rho guanine nucleotide exchange factors (GEFs)
D KLMA_10630 uncharacterized protein K05727 DOCK3; dedicator of cytokinesis protein 3
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: September 2, 2024