+C Two-component system KO
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Two-Component System - Klebsiella pneumoniae subsp. pneumoniae MGH 78578 (serotype K52)
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AOmpR family
B PhoR-PhoB (phosphate starvation response)
C KPN_00341 phoR; positive and negative sensor protein for pho regulon K07636 phoR; two-component system, OmpR family, phosphate regulon sensor histidine kinase PhoR [EC:2.7.13.3]
C KPN_00340 phoB; positive response regulator for pho regulon, sensor is PhoR (or CreC) K07657 phoB; two-component system, OmpR family, phosphate regulon response regulator PhoB
B SenX3-RegX3 (phosphate starvation response)
B PhoQ-PhoP (magnesium transport)
C KPN_01135 phoQ; sensor protein PhoQ K07637 phoQ; two-component system, OmpR family, sensor histidine kinase PhoQ [EC:2.7.13.3]
C KPN_01136 phoP; response regulator in two-component regulatory system with PhoQ, regulates gene expression at low K07660 phoP; two-component system, OmpR family, response regulator PhoP
C KPN_02523 putative response regulator receiver K07660 phoP; two-component system, OmpR family, response regulator PhoP
B EnvZ-OmpR (osmotic stress response)
C KPN_03774 envZ; osmolarity sensor protein K07638 envZ; two-component system, OmpR family, osmolarity sensor histidine kinase EnvZ [EC:2.7.13.3]
C KPN_03775 ompR; osmolarity response regulator K07659 ompR; two-component system, OmpR family, phosphate regulon response regulator OmpR
B RstB-RstA
C KPN_01519 rstB; sensor histidine protein kinase (RstA regulator) K07639 rstB; two-component system, OmpR family, sensor histidine kinase RstB [EC:2.7.13.3]
C KPN_01521 rstA; response regulator (activator) in two-component regulatory system with RstB (OmpR family) K07661 rstA; two-component system, OmpR family, response regulator RstA
B CpxA-CpxR (envelope stress response)
C KPN_04219 cpxA; two-component sensor protein K07640 cpxA; two-component system, OmpR family, sensor histidine kinase CpxA [EC:2.7.13.3]
C KPN_04220 cpxR; response regulator in two-component regulatory system with CpxA, regulates expression of stress-related genes (OmpR family) K07662 cpxR; two-component system, OmpR family, response regulator CpxR
B CssS-CssR (secretion stress response)
B CreC-CreB (phosphate regulation)
C KPN_04854 creC; catabolite repression sensor kinase for PhoB K07641 creC; two-component system, OmpR family, sensor histidine kinase CreC [EC:2.7.13.3]
C KPN_04853 creB; catabolic regulation response regulator K07663 creB; two-component system, OmpR family, catabolic regulation response regulator CreB
B BaeS-BaeR (envelope stress response)
C KPN_02530 baeS; sensor protein (for BaeR) K07642 baeS; two-component system, OmpR family, sensor histidine kinase BaeS [EC:2.7.13.3]
C KPN_02531 baeR; response regulator in two-component regulatory system with BaeS (OmpR family) K07664 baeR; two-component system, OmpR family, response regulator BaeR
B BasS-BasR (antimicrobial peptide resistance)
C KPN_00806 sensor protein for basR K07643 basS; two-component system, OmpR family, sensor histidine kinase BasS [EC:2.7.13.3]
C KPN_00807 response regulator in two-component regulatory system with BasS (OmpR family) K07771 basR; two-component system, OmpR family, response regulator BasR
B CusS-CusR (copper tolerance)
C KPN_04741 copper sensing two-component system sensor kinase K07644 cusS; two-component system, OmpR family, heavy metal sensor histidine kinase CusS [EC:2.7.13.3]
C KPN_pKPN3p05951 silS; probable sensor kinase (silver resistance) K07644 cusS; two-component system, OmpR family, heavy metal sensor histidine kinase CusS [EC:2.7.13.3]
C KPN_04740 response regulator in two-component regulatory system with CusS, regulation of copper resistance K07665 cusR; two-component system, OmpR family, copper resistance phosphate regulon response regulator CusR
C KPN_pKPN3p05937 pcoR; transcriptional regulatory protein PcoR K07665 cusR; two-component system, OmpR family, copper resistance phosphate regulon response regulator CusR
C KPN_pKPN3p05950 silR; probable transcriptional regulatory protein(silver resistance) K07665 cusR; two-component system, OmpR family, copper resistance phosphate regulon response regulator CusR
B QseC-QseB (quorum sensing)
C KPN_03441 ygiY; putative 2-component sensor protein K07645 qseC; two-component system, OmpR family, sensor histidine kinase QseC [EC:2.7.13.3]
C KPN_03440 ygiX; putative 2-component transcriptional regulator K07666 qseB; two-component system, OmpR family, response regulator QseB
B KdpD-KdpE (potassium transport)
C KPN_00714 kdpD; sensor for high-affinity potassium transport system K07646 kdpD; two-component system, OmpR family, sensor histidine kinase KdpD [EC:2.7.13.3]
C KPN_00713 kdpE; regulator of kdp operon (transcriptional effector) K07667 kdpE; two-component system, OmpR family, KDP operon response regulator KdpE
B TorS-TorR (TMAO respiration)
B ArcB-ArcA (anoxic redox control)
C KPN_03619 arcB; aerobic respiration sensor-response protein; histidine protein kinase/phosphatase, sensor for arcA K07648 arcB; two-component system, OmpR family, aerobic respiration control sensor histidine kinase ArcB [EC:2.7.13.3]
C KPN_04856 arcA; negative response regulator of genes in aerobic pathways, (sensors, ArcB and CpxA) K07773 arcA; two-component system, OmpR family, aerobic respiration control protein ArcA
B TctE-TctD (tricarboxylic acid transport)
B ResE-ResD (aerobic and anaerobic respiration)
B VicK-VicR (cell wall metabolism)
B MprB-MprA (maintenance of persistent infection)
B MtrB-MtrA (osmotic stress response)
B PrrB-PrrA (intracellular multiplication)
B TrcS-TrcR
B NrsS-NrsR (nickel tolerance)
B ManS-ManR (manganese homeostasis)
B NblS-NblR (photosynthesis)
B SasA-RpaAB (circadian timing mediating)
B SaeS-SaeR (staphylococcal virulence regulation)
B BceS-BceR (bacitracin transport)
B BraS-BraR (bacitracin transport)
B GraS-GraR (cationic antimicrobial peptide transport)
B YxdK-YxdJ (antimicrobial peptide response)
B ChvG-ChvI (acidity sensing)
B CiaH-CiaR
B ParS-ParR (polymyxin-adaptive resistance)
B AdeS-AdeR
C KPN_02067 sensor histidine protein kinase (RstA regulator) K18143 adeS; two-component system, OmpR family, sensor histidine kinase AdeS [EC:2.7.13.3]
C KPN_02066 putative response regulator consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain K18144 adeR; two-component system, OmpR family, response regulator AdeR
B VanS-VanR (VanB type vancomycin resistance)
B VanS-VanR (VanE type vancomycin resistance)
B VanS-VanR (actinomycete type vancomycin resistance)
B ArlS-ArlR (virulence regulation)
B Ihk-Irr (virulence regulation)
B PfeS-PfeR (enterobactin-dependent iron acquisition)
B NisK-NisR (lantibiotic biosynthesis)
B Unclassified
C KPN_01807 putative transcriptional regulatory protein, C-terminal K02483 K02483; two-component system, OmpR family, response regulator
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ANarL family
B NarX-NarL (nitrate respiration)
C KPN_02216 narX; nitrate/nitrate sensor, histidine protein kinase K07673 narX; two-component system, NarL family, nitrate/nitrite sensor histidine kinase NarX [EC:2.7.13.3]
C KPN_02217 narL; pleiotrophic regulation of anaerobic respiration K07684 narL; two-component system, NarL family, nitrate/nitrite response regulator NarL
B NarQ-NarP (nitrate respiration)
B UhpB-UhpA (hexose phosphates uptake)
C KPN_04071 uhpB; sensor histidine protein kinase phosphorylates UhpA K07675 uhpB; two-component system, NarL family, sensor histidine kinase UhpB [EC:2.7.13.3]
C KPN_04072 uhpA; response regulator (activator) in two-component regulatory system wtih UhpB, regulates uhpT expression (LuxR/UhpA family) K07686 uhpA; two-component system, NarL family, uhpT operon response regulator UhpA
B FusK-FusR (virulence regulation)
B RcsC-RcsD-RcsB (capsule synthesis)
C KPN_02639 rcsC; hybrid sensory histidine kinase in two-component regulatory system with RcsB K07677 rcsC; two-component system, NarL family, capsular synthesis sensor histidine kinase RcsC [EC:2.7.13.3]
C KPN_02637 yojN; putative 2-component sensor protein K07676 rcsD; two-component system, NarL family, sensor histidine kinase RcsD [EC:2.7.13.3]
C KPN_02638 rcsB; positive response regulator for colanic capsule biosynthesis, (sensor, RcsC) K07687 rcsB; two-component system, NarL family, captular synthesis response regulator RcsB
B BarA-UvrY (central carbon metabolism)
C KPN_03128 barA; hybrid sensory histidine kinase in two-component regulatory system with UvrY K07678 barA; two-component system, NarL family, sensor histidine kinase BarA [EC:2.7.13.3]
C KPN_02412 uvrY; response regulator K07689 uvrY; two-component system, NarL family, invasion response regulator UvrY
B ComP-ComA (competence)
B EvgS-EvgA (acid and drug tolerance)
C KPN_03481 evgS; putative sensor protein EvgS1 K07679 evgS; two-component system, NarL family, sensor histidine kinase EvgS [EC:2.7.13.3]
C KPN_03480 evgA; putative bacterial regulatory protein, LuxR K07690 evgA; two-component system, NarL family, response regulator EvgA
B DegS-DegU (multicellular behavior control)
B DesK-DesR (membrane lipid fluidity regulation)
B VraS-VraR (cell-wall peptidoglycan synthesis)
B LiaS-LiaR (cell wall stress response)
B DevS-DevR (redox response)
B NreB-NreC (dissimilatory nitrate/nitrite reduction)
B YdfH-YdfI
B SalK-SalR
B PprA–PprB (biofilm formation)
B Unclassified
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ASpo family
B KinABCDE-Spo0FA (sporulation control)
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ACitB family
B CitA-CitB (citrate fermentation)
C KPN_00054 two-component sensor kinase K07700 dpiB; two-component system, CitB family, cit operon sensor histidine kinase CitA [EC:2.7.13.3]
C KPN_00029 putative transcription regulator, histidine kinase for citrate K07700 dpiB; two-component system, CitB family, cit operon sensor histidine kinase CitA [EC:2.7.13.3]
C KPN_00053 two-component response regulator K07702 dpiA; two-component system, CitB family, response regulator CitB
C KPN_00028 putative transcription regulator sensor for citrate K07702 dpiA; two-component system, CitB family, response regulator CitB
B CitS-CitT (magnesium-citrate transport)
B DcuS-DcuR (C4-dicarboxylate metabolism)
C KPN_01551 dcuS; sensor of fumarate two-component regulatory system K07701 dcuS; two-component system, CitB family, sensor histidine kinase DcuS [EC:2.7.13.3]
C KPN_01550 dcuR; response regulator in two-component regulatory system with DcuS, regulates anaerobic fumarate respiration K07703 dcuR; two-component system, CitB family, response regulator DcuR
B DctS-DctR (C4-dicarboxylate transport)
B MalK-MalR (malate transport)
B Unclassified
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ALytTR family
B LysS-LysR
B AlgZ-AlgR (alginate production)
B NatK-NatR (sodium extrusion)
B AgrC-AgrA (exoprotein synthesis)
B AgrC2-AgrA2 (virulence regulation)
B ComD-ComE (competence)
B Unclassified
C KPN_02563 yehU; putative 2-component sensor protein K02478 K02478; two-component system, LytTR family, sensor kinase [EC:2.7.13.3]
C KPN_02736 ypdA; putative sensor protein K02478 K02478; two-component system, LytTR family, sensor kinase [EC:2.7.13.3]
C KPN_02562 yehT; putative response regulator in two-compoent regulatory system K02477 K02477; two-component system, LytTR family, response regulator
C KPN_02737 ypdB; putative 2-component transcriptional regulator K02477 K02477; two-component system, LytTR family, response regulator
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ANtrC family
B GlnL-GlnG (nitrogen regulation)
C KPN_04177 glnL; histidine protein kinase sensor for GlnG regulator (nitrogen regulator II, NRII) K07708 glnL; two-component system, NtrC family, nitrogen regulation sensor histidine kinase GlnL [EC:2.7.13.3]
C KPN_04176 glnG; response regulator for gln (sensor glnL) (nitrogen regulator I, NRI) K07712 glnG; two-component system, NtrC family, nitrogen regulation response regulator GlnG
B NtrY-NtrX (nitrogen regulation)
B HydH-HydG (metal tolerance)
C KPN_04385 zraS; sensor kinase of Zn/Pb responsive two-component regulatory system K07709 zraS; two-component system, NtrC family, sensor histidine kinase HydH [EC:2.7.13.3]
C KPN_04386 zraR; response regulator in two-component reguatory system with ZraS, regulates zraP expression (EBP family) K07713 zraR; two-component system, NtrC family, response regulator HydG
B AtoS-AtoC (cPHB biosynthesis)
B PilS-PilR (type 4 fimbriae synthesis)
B GlrK-GlrR (amino sugar metabolism)
C KPN_02881 yfhK; putative 2-component sensor protein K07711 glrK; two-component system, NtrC family, sensor histidine kinase GlrK [EC:2.7.13.3]
C KPN_02879 yfhA; putative 2-component transcriptional regulator K07715 glrR; two-component system, NtrC family, response regulator GlrR
B PgtB-PgtA (phosphoglycerate transport)
C KPN_01722 pgtB; Phosphoglycerate transport: protein for signal transmission K08475 pgtB; two-component system, NtrC family, phosphoglycerate transport system sensor histidine kinase PgtB [EC:2.7.13.3]
C KPN_01721 pgtA; Phosphoglycerate transport: activator K08476 pgtA; two-component system, NtrC family, phosphoglycerate transport system response regulator PgtA
B DctB-DctD (C4-dicarboxylate transport)
B KinB-AlgB (alginate production)
B HupT-HupR (hydrogenase synthesis regulation)
B Unclassified
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ACheA family
B CheA-CheYBV (chemotaxis)
B ChpA-ChpB/PilGH (chemosensory)
B PixL-PixGH (positive phototaxis)
B WspE-WspRF (chemosensory)
B Cph1-Rcp1 (light response)
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ACell cycle family
B PleC-PleD (cell fate control)
B CckA-CtrA/CpdR (cell cycle control)
B Hk1-Rrp1 (glycerol uptake and utilization)
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ALux family
B LuxQN/CqsS-LuxU-LuxO (quorum sensing)
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ALuxR family
B DctS-DctR (C4-dicarboxylate transport)
B TtrS-TtrR (tetrathionate respiration)
B FixL-FixJ (nitrogen fixation)
B SsrA-SsrB
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AOther families
B FlrB-FlrC (polar flagellar synthesis)
B AauS-AauR (acidic amino acids utilization)
B SLN1-YPD1-SSK1/SKN7 (osmosensing)
B RpfC-RpfG (cell-to-cell signaling)
B GlnK-GlnL (glutamine utilization)
B HspS-HspR (hexose phosphates uptake)
B YesM-YesN
B CikA
B RegB-RegA (redox response)
B FitF-FitH (insecticidal toxin regulation)
B PhcS-PhcRQ
B SagS-HptB-HsbR (swarming activity and biofilm formation)
B PdtaS-PdtaR
B NasS-NasT
B Unclassified
C KPN_02203 hnr; Hnr protein K02485 rssB; two-component system, response regulator
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: December 14, 2023