+E Replication protein KO
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DNA Replication Proteins - Loxodonta africana (African savanna elephant)
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AEukaryotic type
B DNA Replication Initiation Factors
C pre-RC (pre-replication complex)
D 100654416 ORC1; LOW QUALITY PROTEIN: origin recognition complex subunit 1 K02603 ORC1; origin recognition complex subunit 1
D 100661691 ORC2; origin recognition complex subunit 2 isoform X2 K02604 ORC2; origin recognition complex subunit 2
D 100671809 ORC3; origin recognition complex subunit 3 isoform X4 K02605 ORC3; origin recognition complex subunit 3
D 100658931 ORC4; LOW QUALITY PROTEIN: origin recognition complex subunit 4 K02606 ORC4; origin recognition complex subunit 4
D 100670785 ORC5; LOW QUALITY PROTEIN: origin recognition complex subunit 5 K02607 ORC5; origin recognition complex subunit 5
D 100668093 ORC6; origin recognition complex subunit 6 K02608 ORC6; origin recognition complex subunit 6
D 100674179 CDT1; DNA replication factor Cdt1 K10727 CDT1; chromatin licensing and DNA replication factor 1
D 100666475 CDC6; cell division control protein 6 homolog K02213 CDC6; cell division control protein 6
D 100671272 MCM2; DNA replication licensing factor MCM2 isoform X2 K02540 MCM2; DNA replication licensing factor MCM2 [EC:5.6.2.3]
D 100672480 MCM3; DNA replication licensing factor MCM3 isoform X1 K02541 MCM3; DNA replication licensing factor MCM3 [EC:5.6.2.3]
D 100667013 MCM4; DNA replication licensing factor MCM4 K02212 MCM4; DNA replication licensing factor MCM4 [EC:5.6.2.3]
D 100673228 MCM5; DNA replication licensing factor MCM5 K02209 MCM5; DNA replication licensing factor MCM5 [EC:5.6.2.3]
D 100661316 MCM6; DNA replication licensing factor MCM6 K02542 MCM6; DNA replication licensing factor MCM6 [EC:5.6.2.3]
D 100656457 MCM7; DNA replication licensing factor MCM7 isoform X2 K02210 MCM7; DNA replication licensing factor MCM7 [EC:5.6.2.3]
C CDK (cyclin dependent kinase)
D 100654979 CCNA2; cyclin-A2 K06627 CCNA; cyclin-A
D 100667107 CCNA1; cyclin-A1 K06627 CCNA; cyclin-A
D 100659451 CCNE1; G1/S-specific cyclin-E1 isoform X1 K06626 CCNE; G1/S-specific cyclin-E1
D 100668342 CCNE2; G1/S-specific cyclin-E2 isoform X1 K06626 CCNE; G1/S-specific cyclin-E1
D 100668134 CDK2; cyclin-dependent kinase 2 isoform X2 K02206 CDK2; cyclin-dependent kinase 2 [EC:2.7.11.22]
C DDK (Dbf-4 dependent kinase)
D 100671783 CDC7; cell division cycle 7-related protein kinase K02214 CDC7; cell division control protein 7 [EC:2.7.11.1]
D 100655281 DBF4B; protein DBF4 homolog B K06629 DBF4; protein DBF4
D 100661043 DBF4; protein DBF4 homolog A K06629 DBF4; protein DBF4
C GINS complex
D 111751100 GINS1; DNA replication complex GINS protein PSF1 isoform X1 K10732 GINS1; GINS complex subunit 1
D 100656148 GINS2; DNA replication complex GINS protein PSF2 K10733 GINS2; GINS complex subunit 2
D 100677298 GINS3; DNA replication complex GINS protein PSF3 K10734 GINS3; GINS complex subunit 3
D 100659257 GINS4; DNA replication complex GINS protein SLD5 isoform X1 K10735 GINS4; GINS complex subunit 4
C Other initiation factors
D 100670751 TOPBP1; DNA topoisomerase 2-binding protein 1 isoform X1 K10728 TOPBP1; topoisomerase (DNA) II binding protein 1
D 100664622 RECQL4; ATP-dependent DNA helicase Q4 K10730 RECQL4; ATP-dependent DNA helicase Q4 [EC:5.6.2.4]
D 100668577 CDC45; cell division control protein 45 homolog K06628 CDC45; cell division control protein 45
D 100661153 MCM8; DNA helicase MCM8 isoform X1 K10737 MCM8; DNA helicase MCM8 [EC:5.6.2.4]
D 100665082 MCM9; DNA helicase MCM9 isoform X1 K10738 MCM9; DNA helicase MCM9 [EC:5.6.2.4]
D 100677357 MCM10; protein MCM10 homolog K10736 MCM10; minichromosome maintenance protein 10
D 100662532 MCMBP; mini-chromosome maintenance complex-binding protein K28390 MCMBP; minichromosome maintenance complex-binding protein
D 100668035 HELB; DNA helicase B isoform X1 K15254 HELB; DNA helicase B [EC:5.6.2.3]
D 100673440 FAM111A; protein FAM111A K24274 FAM111A; protein FAM111A
D 100669839 CINP; cyclin-dependent kinase 2-interacting protein isoform X1 K26052 CINP; cyclin-dependent kinase 2-interacting protein
D 100661246 MTBP; LOW QUALITY PROTEIN: mdm2-binding protein K26116 MTBP; Mdm2-binding protein
D 100663906 TICRR; LOW QUALITY PROTEIN: treslin K26117 TICRR; Treslin
B DNA Replication Elongation Factors
C DNA polymerase alpha / primase complex
D 100670916 POLA1; DNA polymerase alpha catalytic subunit K02320 POLA1; DNA polymerase alpha subunit A [EC:2.7.7.7]
D 100662328 POLA2; LOW QUALITY PROTEIN: DNA polymerase alpha subunit B K02321 POLA2; DNA polymerase alpha subunit B
D 100674292 PRIM1; DNA primase small subunit K02684 PRI1; DNA primase small subunit [EC:2.7.7.102]
D 100664795 PRIM2; DNA primase large subunit K02685 PRI2; DNA primase large subunit
C DNA polymerase epsilon complex
D 100655118 POLE; DNA polymerase epsilon catalytic subunit A isoform X1 K02324 POLE; DNA polymerase epsilon subunit 1 [EC:2.7.7.7]
D 100673367 POLE2; DNA polymerase epsilon subunit 2 isoform X1 K02325 POLE2; DNA polymerase epsilon subunit 2 [EC:2.7.7.7]
D 104845639 POLE3; DNA polymerase epsilon subunit 3 K02326 POLE3; DNA polymerase epsilon subunit 3 [EC:2.7.7.7]
C DNA polymerase delta complex
D 100656381 POLD1; DNA polymerase delta catalytic subunit K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
D 100657668 POLD2; DNA polymerase delta subunit 2 K02328 POLD2; DNA polymerase delta subunit 2
D 100667439 POLD3; DNA polymerase delta subunit 3 K03504 POLD3; DNA polymerase delta subunit 3
D 100674373 POLD4; DNA polymerase delta subunit 4 isoform X1 K03505 POLD4; DNA polymerase delta subunit 4
C DNA polymerase gamma complex (mitochondrial)
D 100675301 POLG; DNA polymerase subunit gamma-1 isoform X1 K02332 POLG; DNA polymerase gamma 1 [EC:2.7.7.7]
D 100668479 POLG2; DNA polymerase subunit gamma-2, mitochondrial isoform X1 K02333 POLG2; DNA polymerase gamma 2
C RPA (replication protein A)
D 100661458 RPA1; replication protein A 70 kDa DNA-binding subunit K07466 RFA1; replication factor A1
D 100656421 RPA2; replication protein A 32 kDa subunit K10739 RFA2; replication factor A2
D 104846846 RPA4; LOW QUALITY PROTEIN: replication protein A 30 kDa subunit K10741 RPA4; replication factor A4
C RFC (replication factor C)
D 100659253 RFC1; replication factor C subunit 1 isoform X1 K10754 RFC1; replication factor C subunit 1
D 100664093 RFC4; replication factor C subunit 4 K10755 RFC2_4; replication factor C subunit 2/4
D 100674743 RFC2; replication factor C subunit 2 isoform X1 K10755 RFC2_4; replication factor C subunit 2/4
D 100654256 RFC5; replication factor C subunit 5 isoform X1 K10756 RFC3_5; replication factor C subunit 3/5
D 100663797 RFC3; replication factor C subunit 3 isoform X1 K10756 RFC3_5; replication factor C subunit 3/5
C RNase H
D 100655166 ribonuclease H1-like K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
D 100660393 RNASEH1; ribonuclease H1 K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
D 100654423 RNASEH2A; ribonuclease H2 subunit A isoform X3 K10743 RNASEH2A; ribonuclease H2 subunit A [EC:3.1.26.4]
D 100675767 RNASEH2B; LOW QUALITY PROTEIN: ribonuclease H2 subunit B K10744 RNASEH2B; ribonuclease H2 subunit B
D 100659944 RNASEH2C; ribonuclease H2 subunit C K10745 RNASEH2C; ribonuclease H2 subunit C
C Other elongation factors
D 100661828 PCNA; proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
D 100677776 FEN1; LOW QUALITY PROTEIN: flap endonuclease 1 K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
D 100655264 EXO1; exonuclease 1 K10746 EXO1; exonuclease 1 [EC:3.1.-.-]
D 100662723 ZRANB3; DNA annealing helicase and endonuclease ZRANB3 isoform X6 K25861 ZRANB3; DNA annealing helicase and endonuclease ZRANB3 [EC:5.6.2.- 3.1.-.-]
D 100663865 LIG1; DNA ligase 1 isoform X1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
D 100665528 ATAD5; ATPase family AAA domain-containing protein 5 K26118 ATAD5; ATPase family AAA domain-containing protein 5
B DNA Replication Termination Factors
C DNA methylation enzymes
D 100663618 DNMT1; DNA (cytosine-5)-methyltransferase 1 isoform X1 K00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]
D 100660290 DNMT3B; DNA (cytosine-5)-methyltransferase 3B isoform X2 K17399 DNMT3B; DNA (cytosine-5)-methyltransferase 3B [EC:2.1.1.37]
C Prevention of re-replication factors
D 100676816 GMNN; geminin K10749 GMNN; geminin
D 100667770 MCIDAS; multicilin K26119 MCIDAS; multicilin
D 100654684 CCNB1; G2/mitotic-specific cyclin-B1 K05868 CCNB1; G2/mitotic-specific cyclin-B1
D 100659655 CCNB2; G2/mitotic-specific cyclin-B2 K21770 CCNB2; G2/mitotic-specific cyclin-B2
D 100673511 CCNB3; G2/mitotic-specific cyclin-B3 K21771 CCNB3; G2/mitotic-specific cyclin-B3
D 100668529 CDK1; cyclin-dependent kinase 1 isoform X1 K02087 CDK1; cyclin-dependent kinase 1 [EC:2.7.11.22 2.7.11.23]
C Telomere proteins
D Shelterin complex
E 100661894 POT1; protection of telomeres protein 1 isoform X3 K11109 POT1; protection of telomeres protein 1
E 100654581 TERF1; telomeric repeat-binding factor 1 isoform X2 K11110 TERF1; telomeric repeat-binding factor 1
E 100667997 TERF2; LOW QUALITY PROTEIN: telomeric repeat-binding factor 2 K11111 TERF2; telomeric repeat-binding factor 2
E 100655591 TINF2; TERF1-interacting nuclear factor 2 K11112 TINF2; TERF1-interacting nuclear factor 2
E 100674645 TERF2IP; telomeric repeat-binding factor 2-interacting protein 1 K11113 TERF2IP; telomeric repeat-binding factor 2-interacting protein 1
E 100661748 ACD; adrenocortical dysplasia protein homolog isoform X3 K11114 ACD; adrenocortical dysplasia protein
D TERB1-TERB2-MAJIN complex
E 111752569 TERB1; telomere repeats-binding bouquet formation protein 1 K25749 TERB1; telomere repeats-binding bouquet formation protein 1
E 100654260 TERB2; telomere repeats-binding bouquet formation protein 2 K25750 TERB2; telomere repeats-binding bouquet formation protein 2
E 100660139 MAJIN; LOW QUALITY PROTEIN: membrane-anchored junction protein K25751 MAJIN; membrane-anchored junction protein
D CST complex (animals)
E 100673023 CTC1; CST complex subunit CTC1 K23311 CTC1; CST complex subunit CTC1
E 100676415 STN1; CST complex subunit STN1 isoform X1 K23312 STN1; CST complex subunit STN1
E 100670172 TEN1; CST complex subunit TEN1 K23313 TEN1; CST complex subunit TEN1
D CST complex (yeast)
D RIF proteins
D SIR proteins
C Telomerase complex (animals)
D 100661745 SMG6; telomerase-binding protein EST1A isoform X2 K11124 SMG6; protein SMG6 [EC:3.1.-.-]
D 100670731 SMG5; protein SMG5 isoform X1 K11125 SMG5; protein SMG5
D 100676312 TERT; telomerase reverse transcriptase K11126 TERT; telomerase reverse transcriptase [EC:2.7.7.49]
D 100677230 TEP1; telomerase protein component 1 K11127 TEP1; telomerase protein component 1
D Dyskerin complex
E 100669280 GAR1; H/ACA ribonucleoprotein complex subunit 1 K11128 GAR1; H/ACA ribonucleoprotein complex subunit 1
E 100675054 NHP2; H/ACA ribonucleoprotein complex subunit 2 K11129 NHP2; H/ACA ribonucleoprotein complex subunit 2
E 100654445 NOP10; H/ACA ribonucleoprotein complex subunit 3 K11130 NOP10; H/ACA ribonucleoprotein complex subunit 3
E 100671610 DKC1; H/ACA ribonucleoprotein complex subunit 4 K11131 DKC1; H/ACA ribonucleoprotein complex subunit 4 [EC:5.4.99.-]
C Telomerase complex (fungi)
D 100676312 TERT; telomerase reverse transcriptase K11126 TERT; telomerase reverse transcriptase [EC:2.7.7.49]
D Sm core complex
E 100670616 SNRPB; small nuclear ribonucleoprotein-associated proteins B and B' K11086 SNRPB; small nuclear ribonucleoprotein B and B'
E 100665200 SNRPD1; small nuclear ribonucleoprotein Sm D1 K11087 SNRPD1; small nuclear ribonucleoprotein D1
E 111750687 small nuclear ribonucleoprotein Sm D1-like K11087 SNRPD1; small nuclear ribonucleoprotein D1
E 100671545 SNRPD2; small nuclear ribonucleoprotein Sm D2 K11096 SNRPD2; small nuclear ribonucleoprotein D2
E 100662794 SNRPD3; small nuclear ribonucleoprotein Sm D3 K11088 SNRPD3; small nuclear ribonucleoprotein D3
E 100657355 SNRPE; small nuclear ribonucleoprotein E isoform X1 K11097 SNRPE; small nuclear ribonucleoprotein E
E 111749643 small nuclear ribonucleoprotein E-like K11097 SNRPE; small nuclear ribonucleoprotein E
E 100662636 SNRPF; small nuclear ribonucleoprotein F K11098 SNRPF; small nuclear ribonucleoprotein F
E 100674732 SNRPG; small nuclear ribonucleoprotein G isoform X1 K11099 SNRPG; small nuclear ribonucleoprotein G
C ELG1-RFC complex
D 100664093 RFC4; replication factor C subunit 4 K10755 RFC2_4; replication factor C subunit 2/4
D 100674743 RFC2; replication factor C subunit 2 isoform X1 K10755 RFC2_4; replication factor C subunit 2/4
D 100654256 RFC5; replication factor C subunit 5 isoform X1 K10756 RFC3_5; replication factor C subunit 3/5
D 100663797 RFC3; replication factor C subunit 3 isoform X1 K10756 RFC3_5; replication factor C subunit 3/5
C MRN complex
D 100673017 MRE11; double-strand break repair protein MRE11 isoform X1 K10865 MRE11; double-strand break repair protein MRE11
D 100663283 RAD50; DNA repair protein RAD50 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
D 100663790 NBN; nibrin isoform X1 K10867 NBN; nibrin
C Other termination factors
D 100663914 ATM; serine-protein kinase ATM isoform X1 K04728 ATM; serine-protein kinase ATM [EC:2.7.11.1]
D 100669012 WRN; Werner syndrome ATP-dependent helicase isoform X1 K10900 WRN; werner syndrome ATP-dependent helicase [EC:5.6.2.4]
D 100669675 BLM; Bloom syndrome protein isoform X1 K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
D 100667300 PRKDC; DNA-dependent protein kinase catalytic subunit isoform X1 K06642 PRKDC; DNA-dependent protein kinase catalytic subunit [EC:2.7.11.1]
D 100655576 ERCC4; DNA repair endonuclease XPF isoform X1 K10848 ERCC4; DNA excision repair protein ERCC-4 [EC:3.1.-.-]
D 100660971 PARP1; poly [ADP-ribose] polymerase 1 K24070 PARP1; poly [ADP-ribose] polymerase 1 [EC:2.4.2.30]
D 100661865 PARP2; poly [ADP-ribose] polymerase 2 isoform X1 K28005 PARP2; poly [ADP-ribose] polymerase 2 [EC:2.4.2.30]
D 100656203 TNKS2; tankyrase-2 isoform X2 K10799 TNKS; tankyrase [EC:2.4.2.30]
D 100671187 TNKS; tankyrase-1 K10799 TNKS; tankyrase [EC:2.4.2.30]
D 100664754 PINX1; PIN2/TERF1-interacting telomerase inhibitor 1 isoform X1 K11135 PINX1; Pin2-interacting protein X1
D 100670947 RTEL1; LOW QUALITY PROTEIN: regulator of telomere elongation helicase 1 K11136 RTEL1; regulator of telomere elongation helicase 1 [EC:5.6.2.3]
D 100667998 TELO2; telomere length regulation protein TEL2 homolog isoform X2 K11137 TELO2; telomere length regulation protein
D 100655557 TRIR; telomerase RNA component interacting RNase isoform X2 K01149 TRIR; telomerase RNA component interacting RNase [EC:3.1.13.-]
D 100657507 RIF1; LOW QUALITY PROTEIN: telomere-associated protein RIF1 K11138 RIF1; telomere-associated protein RIF1
D 100671979 PIF1; LOW QUALITY PROTEIN: ATP-dependent DNA helicase PIF1 K15255 PIF1; ATP-dependent DNA helicase PIF1 [EC:5.6.2.3]
D 104845997 PURA; LOW QUALITY PROTEIN: transcriptional activator protein Pur-alpha K21772 PURA; transcriptional activator protein Pur-alpha
D 100669290 PURG; purine-rich element-binding protein gamma K21800 PURG; purine-rich element-binding protein gamma
D 100669033 WRAP53; LOW QUALITY PROTEIN: telomerase Cajal body protein 1 K23314 WRAP53; telomerase Cajal body protein 1
D 100672901 SDE2; replication stress response regulator SDE2 K25059 SDE2; replication stress response regulator SDE2
D 100665734 RTF2; protein RTF2 homolog K25186 RTF2; replication termination factor 2
B DNA Topoisomerases
C 100677455 TOP1; DNA topoisomerase 1 isoform X1 K03163 TOP1; DNA topoisomerase I [EC:5.6.2.1]
C 100667411 TOP2A; DNA topoisomerase 2-alpha K03164 TOP2; DNA topoisomerase II [EC:5.6.2.2]
C 100668841 TOP2B; DNA topoisomerase 2-beta K03164 TOP2; DNA topoisomerase II [EC:5.6.2.2]
C 100653972 TOP3B; DNA topoisomerase 3-beta-1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
C 100669795 TOP3A; DNA topoisomerase 3-alpha isoform X2 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
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AProkaryotic type
B DNA Replication Initiation Factors
C Initiation factors (bacterial)
D 100662695 SSBP1; single-stranded DNA-binding protein, mitochondrial K03111 ssb; single-strand DNA-binding protein
C Initiation factors (archaeal)
B DNA Replication Elongation Factors
C Elongation factors (bacterial)
D DNA polymerase III holoenzyme
D RNase H
E 100655166 ribonuclease H1-like K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
E 100660393 RNASEH1; ribonuclease H1 K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
D Other elongation factors
C Elongation factors (archaeal)
D B-family DNA polymerases
D D-family DNA polymerases
D RNase H
E 100655166 ribonuclease H1-like K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
E 100660393 RNASEH1; ribonuclease H1 K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
D RFC (replication factor C)
D Other elongation factors
E 100677776 FEN1; LOW QUALITY PROTEIN: flap endonuclease 1 K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
E 100663865 LIG1; DNA ligase 1 isoform X1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
B DNA Replication Termination Factors
C Terminus site-binding protein
C DNA methylation enzymes
C Prevention of re-replication factors
B DNA Topoisomerases
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: August 27, 2025