+F Repair protein KO
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DNA Repair and Recombination Proteins - Leptospira biflexa serovar Patoc Patoc 1 (Paris)
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AEukaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D LEPBI_I2409 phr; Deoxyribodipyrimidine photolyase (DNA photolyase; Photoreactivating enzyme) K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]
C BER (base exicision repair)
D DNA glycosylases
E LEPBI_I0821 ung; Uracil-DNA glycosylase (UDG) K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E LEPBI_I1287 Putative A/G-specific DNA glycosylase K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
E LEPBI_I1021 nth; Endonuclease III (DNA-(apurinic or apyrimidinic site) lyase) K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
D Long Patch-BER factors
E DNA polymerase delta complex
E DNA polymerase epsilon complex
D Short Patch-BER factors
D Other BER factors
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E XPC-HR23B-CETN2 complex
E Cul4-DDB2 complex
E NER4 complex
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase II complex
E Cul4-CSA complex
E Other TCR factor
D TFIIH complex
E LEPBI_I2544 Putative DNA repair helicase K10843 ERCC3; DNA excision repair protein ERCC-3 [EC:5.6.2.4]
D RPA (replication factor A)
D Other NER factors
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
D MutL homologs
D DNA polymerase delta complex
D RPA (replication factor A)
D RFC (replication factor C)
D Other MMR factors
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D MRN(MRX) complex
D BRCA1-core complex
D BRCA1-A complex
D BRCA1-B complex
D BRCA1-C complex
D BRCA complex
D RecA family proteins
D Rad52 family proteins
D Rad54 family proteins
D RecQ family DNA helicases
D Bloom's syndrome complex (BTR)
D RPA (replication factor A)
D Protein phosphatase 4
D AP-5 complex
D SMC5-SMC6 complex
D Other HR factors
C NHEJ (non-homologous end-joining)
D DNA-PK complex
D MRX complex
D DNA Ligase 4 complex
D X-family DNA polymerases
D Other NHEJ factors
C FA (Fanconi anemia) pathway
D FA core complex
D FA core complex binding factors
D Bloom's syndrome complex (BTR)
D FANCD2-I complex
D Downstream FA components
D Other FA pathway factors
C Other DSBR factors
D Protein phosphatase 6
D Ubiquitin ligases
D Others
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
C B-family DNA polymerases
C A-family DNA polymerase
C Rad6 epistasis group
C Other TLS factors
B Check point factors
C Rad9-Hus1-Rad1 complex
C HRAD17(Rad24)-RFC complex
C Rad17-Mec3-Ddc1 complex
C FPC (fork protection complex)
C Triple T complex
C BAG6-UBL4A-GET4 complex
C Other check point factors
B Other factors with a suspected DNA repair function
C DNA polymerases
C Nucleases
C Helicases
C PSO4 complex
C Modulation of nucleotide pools
D LEPBI_I3287 Conserved hypothetical protein K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D LEPBI_I2583 Putative ADP-ribose pyrophosphatase, NudF subfamily K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D LEPBI_I1531 dut; Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase; dUTP pyrophosphatase) K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
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AProkaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D LEPBI_II0134 ada; Bifunctional protein: transcriptional regulator of DNA repair/O6-methylguanine-DNA methyltransferase K10778 ada; AraC family transcriptional regulator, regulatory protein of adaptative response / methylated-DNA-[protein]-cysteine methyltransferase [EC:2.1.1.63]
D LEPBI_I2409 phr; Deoxyribodipyrimidine photolyase (DNA photolyase; Photoreactivating enzyme) K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]
D LEPBI_I2494 Putative deoxyribodipyrimidine photo-lyase K06876 phrB; (6-4)DNA photolyase [EC:4.1.99.13]
C BER (base exicision repair)
D DNA glycosylases
E LEPBI_I0821 ung; Uracil-DNA glycosylase (UDG) K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E LEPBI_I1287 Putative A/G-specific DNA glycosylase K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
E LEPBI_I1021 nth; Endonuclease III (DNA-(apurinic or apyrimidinic site) lyase) K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
E LEPBI_I1829 exoA; Exodeoxyribonuclease K01142 E3.1.11.2; exodeoxyribonuclease III [EC:3.1.11.2]
D RecJ
E LEPBI_I1309 recJ; Single-stranded-DNA-specific exonuclease RecJ K07462 recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-]
D DNA ligase
E LEPBI_I0217 ligA; DNA ligase (Polydeoxyribonucleotide synthase [NAD+]) K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
D DNA polymerase I
E LEPBI_I0674 polA; DNA polymerase I (POL I) K02335 polA; DNA polymerase I [EC:2.7.7.7]
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E LEPBI_I1837 uvrA; UvrABC system protein A (UvrA protein; Excinuclease ABC subunit A) K03701 uvrA; excinuclease ABC subunit A
E LEPBI_I0845 uvrB; UvrABC system protein B (UvrB protein; Excinuclease ABC subunit B) K03702 uvrB; excinuclease ABC subunit B
E LEPBI_I2076 uvrC; UvrABC system protein C (UvrC protein; Excinuclease ABC subunit C) K03703 uvrC; excinuclease ABC subunit C
E LEPBI_I1634 pcrA1; ATP-dependent DNA helicase PcrA K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E LEPBI_I1736 pcrA3; ATP-dependent DNA helicase PcrA K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E LEPBI_I2066 pcrA4; ATP-dependent DNA helicase PcrA K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E LEPBI_I2378 pcrA2; ATP-dependent DNA helicase PcrA K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E LEPBI_I0674 polA; DNA polymerase I (POL I) K02335 polA; DNA polymerase I [EC:2.7.7.7]
E LEPBI_I0217 ligA; DNA ligase (Polydeoxyribonucleotide synthase [NAD+]) K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase complex (RNAP)
F LEPBI_I1972 rpoB; DNA-directed RNA polymerase beta chain (RNAP beta subunit; Transcriptase beta chain) (RNA polymerase beta subunit) K03043 rpoB; DNA-directed RNA polymerase subunit beta [EC:2.7.7.6]
F LEPBI_I1971 rpoC; DNA-directed RNA polymerase beta' chain K03046 rpoC; DNA-directed RNA polymerase subunit beta' [EC:2.7.7.6]
F LEPBI_I1939 rpoA; DNA-directed RNA polymerase alpha chain K03040 rpoA; DNA-directed RNA polymerase subunit alpha [EC:2.7.7.6]
E TRCF (transcription-repair coupling factor)
F LEPBI_I1823 mfd; Transcription-repair coupling factor (TRCF; ATP-dependent helicase Mfd) K03723 mfd; transcription-repair coupling factor (superfamily II helicase) [EC:5.6.2.4]
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
E LEPBI_I0833 mutS; DNA mismatch repair protein MutS K03555 mutS; DNA mismatch repair protein MutS
D Molecular matchmaker
E LEPBI_I2151 mutL; DNA mismatch repair protein MutL K03572 mutL; DNA mismatch repair protein MutL
D Strand discrimination factor
D DNA exonucleases
E LEPBI_I1860 xseA; Exodeoxyribonuclease VII large subunit (Exonuclease VII large subunit) K03601 xseA; exodeoxyribonuclease VII large subunit [EC:3.1.11.6]
E LEPBI_I1861 xseB; Exodeoxyribonuclease VII small subunit (Exonuclease VII small subunit) K03602 xseB; exodeoxyribonuclease VII small subunit [EC:3.1.11.6]
D DNA polymerase III holoenzyme
E LEPBI_I2936 dnaE; DNA polymerase III alpha subunit K02337 dnaE; DNA polymerase III subunit alpha [EC:2.7.7.7]
E LEPBI_I0002 dnaN; DNA polymerase III, beta chain K02338 dnaN; DNA polymerase III subunit beta [EC:2.7.7.7]
E LEPBI_I0012 Conserved hypothetical protein K02340 holA; DNA polymerase III subunit delta [EC:2.7.7.7]
E LEPBI_I3461 dnaX1; DNA polymerase III gamma subunit K02343 dnaX; DNA polymerase III subunit gamma/tau [EC:2.7.7.7]
E LEPBI_I3479 dnaX2; DNA polymerase III subunit gamma/tau K02343 dnaX; DNA polymerase III subunit gamma/tau [EC:2.7.7.7]
D DNA ligase
E LEPBI_I0217 ligA; DNA ligase (Polydeoxyribonucleotide synthase [NAD+]) K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
D Other MMR factors
E LEPBI_I1634 pcrA1; ATP-dependent DNA helicase PcrA K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E LEPBI_I1736 pcrA3; ATP-dependent DNA helicase PcrA K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E LEPBI_I2066 pcrA4; ATP-dependent DNA helicase PcrA K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E LEPBI_I2378 pcrA2; ATP-dependent DNA helicase PcrA K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E LEPBI_I2099 ssbA; Single-stranded DNA binding protein (SSB; Helix-destabilizing protein) K03111 ssb; single-strand DNA-binding protein
E LEPBI_I2975 ssbB; Single-strand binding protein (SSB; Helix-destabilizing protein) K03111 ssb; single-strand DNA-binding protein
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D RecBC pathway proteins
E LEPBI_p0020 recB; Exodeoxyribonuclease V beta chain, UvrD subfamily K03582 recB; exodeoxyribonuclease V beta subunit [EC:3.1.11.5]
E LEPBI_p0021 recC; Exodeoxyribonuclease V gamma chain K03583 recC; exodeoxyribonuclease V gamma subunit [EC:3.1.11.5]
E LEPBI_p0019 recD; ATP-dependent exoDNAse (exonuclease V), alpha subunit, helicase superfamily I member K03581 recD; exodeoxyribonuclease V alpha subunit [EC:3.1.11.5]
E LEPBI_I2446 recA; Protein RecA (Recombinase A) K03553 recA; recombination protein RecA
E LEPBI_I1501 ruvA; Holliday junction DNA helicase RuvA K03550 ruvA; holliday junction DNA helicase RuvA
E LEPBI_I0524 ruvB; Holliday junction DNA helicase RuvB K03551 ruvB; holliday junction DNA helicase RuvB [EC:5.6.2.4]
E LEPBI_I3318 Putative crossover junction endodeoxyribonuclease RuvC (Holliday junction nuclease ruvC) K01159 ruvC; crossover junction endodeoxyribonuclease RuvC [EC:3.1.21.10]
E LEPBI_I1656 priA; Primosomal protein N' (Replication factor Y) K04066 priA; primosomal protein N' (replication factor Y) (superfamily II helicase) [EC:5.6.2.4]
E LEPBI_I2905 Putative ATPase K03546 sbcC; DNA repair protein SbcC/Rad50
D RecFOR pathway proteins
E LEPBI_I2446 recA; Protein RecA (Recombinase A) K03553 recA; recombination protein RecA
E LEPBI_I0774 radA; DNA repair protein K04485 radA; DNA repair protein RadA/Sms
E LEPBI_I0003 recF; DNA replication and repair protein RecF K03629 recF; DNA replication and repair protein RecF
E LEPBI_I0349 recG; ATP-dependent DNA helicase RecG K03655 recG; ATP-dependent DNA helicase RecG [EC:5.6.2.4]
E LEPBI_I2223 Putative ATP-binding protein K03655 recG; ATP-dependent DNA helicase RecG [EC:5.6.2.4]
E LEPBI_I1309 recJ; Single-stranded-DNA-specific exonuclease RecJ K07462 recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-]
E LEPBI_I2091 recO; DNA repair protein RecO (Recombination protein O) K03584 recO; DNA repair protein RecO (recombination protein O)
E LEPBI_I3463 recR; Recombination protein RecR K06187 recR; recombination protein RecR
E LEPBI_I1630 Putative DNA repair protein RecN K03631 recN; DNA repair protein RecN (Recombination protein N)
E LEPBI_I1501 ruvA; Holliday junction DNA helicase RuvA K03550 ruvA; holliday junction DNA helicase RuvA
E LEPBI_I0524 ruvB; Holliday junction DNA helicase RuvB K03551 ruvB; holliday junction DNA helicase RuvB [EC:5.6.2.4]
E LEPBI_I3318 Putative crossover junction endodeoxyribonuclease RuvC (Holliday junction nuclease ruvC) K01159 ruvC; crossover junction endodeoxyribonuclease RuvC [EC:3.1.21.10]
D AddAB pathway proteins
D Other HR factor
D Archaeal homologous recombinant proteins
E LEPBI_I2905 Putative ATPase K03546 sbcC; DNA repair protein SbcC/Rad50
E LEPBI_I2342 Putative ATPase K06915 herA; DNA double-strand break repair helicase HerA and related ATPase
C NHEJ (non-homologous end-joining)
D Two-component NHEJ DNA repair complex
D SHIIR (short-homology-independent illegitimate recombination)
E Facilitator
F LEPBI_I0006 gyrA1; DNA gyrase subunit A K02469 gyrA; DNA gyrase subunit A [EC:5.6.2.2]
F LEPBI_I0679 gyrA2; DNA gyrase/topoisomerase, type IV, subunit A K02469 gyrA; DNA gyrase subunit A [EC:5.6.2.2]
F LEPBI_I0005 gyrB1; DNA gyrase subunit B K02470 gyrB; DNA gyrase subunit B [EC:5.6.2.2]
F LEPBI_I0680 gyrB2; DNA gyrase/topoisomerase, type IIa, subunit B K02470 gyrB; DNA gyrase subunit B [EC:5.6.2.2]
F LEPBI_I1163 topA; DNA topoisomerase I K03168 topA; DNA topoisomerase I [EC:5.6.2.1]
E Supressor
F LEPBI_II0036 Putative DNA-binding protein (HU-like protein) K03530 hupB; DNA-binding protein HU-beta
D SHDIR (short-homology-dependent illegitimate recombination)
E RecET pathway
F LEPBI_I1309 recJ; Single-stranded-DNA-specific exonuclease RecJ K07462 recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-]
F LEPBI_I2091 recO; DNA repair protein RecO (Recombination protein O) K03584 recO; DNA repair protein RecO (recombination protein O)
F LEPBI_I3463 recR; Recombination protein RecR K06187 recR; recombination protein RecR
F LEPBI_I0217 ligA; DNA ligase (Polydeoxyribonucleotide synthase [NAD+]) K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
E Facilitator
E Supressor
F LEPBI_I0309 recQ1; ATP-dependent DNA helicase RecQ K03654 recQ; ATP-dependent DNA helicase RecQ [EC:5.6.2.4]
F LEPBI_I2503 recQ2; ATP-dependent DNA helicase RecQ K03654 recQ; ATP-dependent DNA helicase RecQ [EC:5.6.2.4]
F LEPBI_I1837 uvrA; UvrABC system protein A (UvrA protein; Excinuclease ABC subunit A) K03701 uvrA; excinuclease ABC subunit A
F LEPBI_I0845 uvrB; UvrABC system protein B (UvrB protein; Excinuclease ABC subunit B) K03702 uvrB; excinuclease ABC subunit B
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
D LEPBI_II0150 dinP; DNA polymerase IV, devoid of proofreading, damage-inducible protein P K02346 dinB; DNA polymerase IV [EC:2.7.7.7]
C Other SOS response factors
D LEPBI_I2446 recA; Protein RecA (Recombinase A) K03553 recA; recombination protein RecA
D LEPBI_I1316 lexA; LexA repressor K01356 lexA; repressor LexA [EC:3.4.21.88]
D LEPBI_I1630 Putative DNA repair protein RecN K03631 recN; DNA repair protein RecN (Recombination protein N)
D LEPBI_I2161 Putative DNA polymerase K02336 polB; DNA polymerase II [EC:2.7.7.7]
D LEPBI_I2099 ssbA; Single-stranded DNA binding protein (SSB; Helix-destabilizing protein) K03111 ssb; single-strand DNA-binding protein
D LEPBI_I2975 ssbB; Single-strand binding protein (SSB; Helix-destabilizing protein) K03111 ssb; single-strand DNA-binding protein
B Other factors with a suspected DNA repair function
C DNA polymerase
C DNA helicases
D LEPBI_I1719 Putative ATP-dependent helicase K03722 dinG; ATP-dependent DNA helicase DinG [EC:5.6.2.3]
C Modulation of nucleotide pools
D LEPBI_I3287 Conserved hypothetical protein K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D LEPBI_I2583 Putative ADP-ribose pyrophosphatase, NudF subfamily K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D LEPBI_I1531 dut; Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase; dUTP pyrophosphatase) K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D LEPBI_I1686 nrdA; Ribonucleoside-diphosphate reductase alpha subunit (Ribonucleotide reductase) K00525 E1.17.4.1A; ribonucleoside-diphosphate reductase alpha chain [EC:1.17.4.1]
D LEPBI_I2177 Hypothetical protein K00526 E1.17.4.1B; ribonucleoside-diphosphate reductase beta chain [EC:1.17.4.1]
C Others
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: March 29, 2024