+F Repair protein KO
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DNA Repair and Recombination Proteins - Leptinotarsa decemlineata (Colorado potato beetle)
%
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AEukaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D 111507421 activating signal cointegrator 1 complex subunit 3-like K18663 ASCC3; activating signal cointegrator complex subunit 3 [EC:5.6.2.4]
D 111512992 deoxyribodipyrimidine photo-lyase-like K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]
C BER (base exicision repair)
D DNA glycosylases
E 111502451 uncharacterized protein LOC111502451 K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E 111505572 uncharacterized protein LOC111505572 K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E 111505574 uncharacterized protein LOC111505574 K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E 111513469 G/T mismatch-specific thymine DNA glycosylase-like isoform X1 K20813 TDG; thymine-DNA glycosylase [EC:3.2.2.29]
E 111514412 pollen-specific leucine-rich repeat extensin-like protein 1 K20813 TDG; thymine-DNA glycosylase [EC:3.2.2.29]
E 111516486 probable DNA-3-methyladenine glycosylase K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]
E 111518123 single-strand selective monofunctional uracil DNA glycosylase-like isoform X1 K10800 SMUG1; single-strand selective monofunctional uracil DNA glycosylase [EC:3.2.2.-]
E 111506019 uncharacterized protein LOC111506019 K10801 MBD4; methyl-CpG-binding domain protein 4 [EC:3.2.2.-]
E 111509888 N-glycosylase/DNA lyase K03660 OGG1; N-glycosylase/DNA lyase [EC:3.2.2.- 4.2.99.18]
E 111513827 endonuclease III-like protein 1 K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
E 111512216 recombination repair protein 1 K10771 APEX1; AP endonuclease 1 [EC:3.1.11.2]
D Long Patch-BER factors
E DNA polymerase delta complex
F 111505428 DNA polymerase delta catalytic subunit K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
F 111505042 DNA polymerase delta small subunit K02328 POLD2; DNA polymerase delta subunit 2
F 111505172 uncharacterized protein LOC111505172 isoform X1 K03504 POLD3; DNA polymerase delta subunit 3
E DNA polymerase epsilon complex
F 111504382 DNA polymerase epsilon catalytic subunit A isoform X1 K02324 POLE; DNA polymerase epsilon subunit 1 [EC:2.7.7.7]
F 111514417 DNA polymerase epsilon subunit 2 K02325 POLE2; DNA polymerase epsilon subunit 2 [EC:2.7.7.7]
F 111505035 DNA polymerase epsilon subunit 3 K02326 POLE3; DNA polymerase epsilon subunit 3 [EC:2.7.7.7]
F 111516971 DNA polymerase epsilon subunit 4 K03506 POLE4; DNA polymerase epsilon subunit 4 [EC:2.7.7.7]
E 111502554 proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
E 111516370 flap endonuclease 1 K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
E 111509963 DNA ligase 1-like K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
D Short Patch-BER factors
E 111515323 DNA polymerase beta-like K02330 POLB; DNA polymerase beta [EC:2.7.7.7 4.2.99.-]
E 111511523 DNA repair protein XRCC1 isoform X1 K10803 XRCC1; DNA-repair protein XRCC1
E 111512127 DNA ligase 3 K10776 LIG3; DNA ligase 3 [EC:6.5.1.1]
D Other BER factors
E 111517887 probable tyrosyl-DNA phosphodiesterase K10862 TDP1; tyrosyl-DNA phosphodiesterase 1 [EC:3.1.4.-]
E 111503849 aprataxin K10863 APTX; aprataxin [EC:3.6.1.70 3.6.1.71 3.6.1.72]
E 111517259 aprataxin and PNK-like factor K13295 APLF; aprataxin and PNK-like factor [EC:3.1.-.-]
E 111509927 aprataxin and PNK-like factor isoform X1 K13295 APLF; aprataxin and PNK-like factor [EC:3.1.-.-]
E 111508517 uncharacterized protein F21D5.5 K08073 PNKP; bifunctional polynucleotide phosphatase/kinase [EC:3.1.3.32 2.7.1.78]
E 111501830 high mobility group protein DSP1 isoform X1 K10802 HMGB1; high mobility group protein B1
E 111513701 poly [ADP-ribose] polymerase K24070 PARP1; poly [ADP-ribose] polymerase 1 [EC:2.4.2.30]
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E XPC-HR23B-CETN2 complex
F 111514803 DNA repair protein complementing XP-C cells homolog K10838 XPC; xeroderma pigmentosum group C-complementing protein
F 111514804 DNA repair protein complementing XP-C cells homolog K10838 XPC; xeroderma pigmentosum group C-complementing protein
E Cul4-DDB2 complex
F 111512846 RING-box protein 1A-like K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
F 111507935 cullin-4B K10609 CUL4; cullin 4
F 111507116 DNA damage-binding protein 1 K10610 DDB1; DNA damage-binding protein 1
E NER4 complex
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase II complex
F 111518111 DNA-directed RNA polymerase II subunit RPB1 K03006 RPB1; DNA-directed RNA polymerase II subunit RPB1 [EC:2.7.7.6]
F 111517801 LOW QUALITY PROTEIN: DNA-directed RNA polymerase II subunit RPB2 K03010 RPB2; DNA-directed RNA polymerase II subunit RPB2 [EC:2.7.7.6]
F 111517142 DNA-directed RNA polymerase II subunit RPB3 K03011 RPB3; DNA-directed RNA polymerase II subunit RPB3
F 111515256 DNA-directed RNA polymerase II subunit RPB4 K03012 RPB4; DNA-directed RNA polymerase II subunit RPB4
F 111509467 DNA-directed RNA polymerases I, II, and III subunit RPABC1 K03013 RPABC1; DNA-directed RNA polymerases I, II, and III subunit RPABC1
F 111504664 DNA-directed RNA polymerases I, II, and III subunit RPABC2 K03014 RPABC2; DNA-directed RNA polymerases I, II, and III subunit RPABC2
F 111503778 DNA-directed RNA polymerase II subunit RPB7 K03015 RPB7; DNA-directed RNA polymerase II subunit RPB7
F 111502209 DNA-directed RNA polymerases I, II, and III subunit RPABC3 K03016 RPABC3; DNA-directed RNA polymerases I, II, and III subunit RPABC3
F 111502686 DNA-directed RNA polymerase II subunit RPB9 K03017 RPB9; DNA-directed RNA polymerase II subunit RPB9
F 111509658 DNA-directed RNA polymerases I, II, and III subunit RPABC5 K03007 RPABC5; DNA-directed RNA polymerases I, II, and III subunit RPABC5
F 111516549 DNA-directed RNA polymerase II subunit RPB11 K03008 RPB11; DNA-directed RNA polymerase II subunit RPB11
F 111508947 DNA-directed RNA polymerases I, II, and III subunit RPABC4 K03009 RPABC4; DNA-directed RNA polymerases I, II, and III subunit RPABC4
E Cul4-CSA complex
F 111512846 RING-box protein 1A-like K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
F 111507935 cullin-4B K10609 CUL4; cullin 4
F 111507116 DNA damage-binding protein 1 K10610 DDB1; DNA damage-binding protein 1
E Other TCR factor
F 111504336 DNA excision repair protein ERCC-6-like isoform X1 K10841 ERCC6; DNA excision repair protein ERCC-6
F 111517238 transcription elongation factor 1 homolog K25829 ELOF1; transcription elongation factor 1
D TFIIH complex
E 111516214 DNA excision repair protein haywire-like K10843 ERCC3; DNA excision repair protein ERCC-3 [EC:5.6.2.4]
E 111509058 TFIIH basal transcription factor complex helicase XPD subunit K10844 ERCC2; DNA excision repair protein ERCC-2 [EC:5.6.2.3]
E 111505499 general transcription factor IIH subunit 1 K03141 TFIIH1; transcription initiation factor TFIIH subunit 1
E 111509104 general transcription factor IIH subunit 2 K03142 TFIIH2; transcription initiation factor TFIIH subunit 2
E 111512009 general transcription factor IIH subunit 3 K03143 TFIIH3; transcription initiation factor TFIIH subunit 3
E 111509774 general transcription factor IIH subunit 4 K03144 TFIIH4; transcription initiation factor TFIIH subunit 4
E 111508255 general transcription factor IIH subunit 5 K10845 TTDA; TFIIH basal transcription factor complex TTD-A subunit
E 111503842 cyclin-dependent kinase 7 K02202 CDK7; cyclin-dependent kinase 7 [EC:2.7.11.22 2.7.11.23]
E 111515923 cyclin-H K06634 CCNH; cyclin H
E 111504726 CDK-activating kinase assembly factor MAT1 K10842 MNAT1; CDK-activating kinase assembly factor MAT1
D RPA (replication factor A)
E 111504718 replication protein A 70 kDa DNA-binding subunit K07466 RFA1; replication factor A1
E 111513952 replication protein A 32 kDa subunit K10739 RFA2; replication factor A2
E 111515205 uncharacterized protein LOC111515205 K10740 RPA3; replication factor A3
E 111509394 uncharacterized protein LOC111509394 K10740 RPA3; replication factor A3
D Other NER factors
E 111511513 DNA repair protein complementing XP-A cells homolog K10847 XPA; DNA-repair protein complementing XP-A cells
E 111514478 DNA excision repair protein ERCC-1 K10849 ERCC1; DNA excision repair protein ERCC-1
E 111502079 DNA repair endonuclease XPF K10848 ERCC4; DNA excision repair protein ERCC-4 [EC:3.1.-.-]
E 111514249 DNA repair protein complementing XP-G cells K10846 ERCC5; DNA excision repair protein ERCC-5
E 111509963 DNA ligase 1-like K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
E 111508625 MMS19 nucleotide excision repair protein homolog isoform X1 K15075 MET18; DNA repair/transcription protein MET18/MMS19
E 111502269 cullin-3 isoform X1 K03869 CUL3; cullin 3
E 111505579 cullin-5 K10612 CUL5; cullin 5
E 111504266 elongin-B K03873 ELOB; elongin-B
E 111514892 transcription elongation factor B polypeptide 3-like K15076 ELOA; elongin-A
E 111503337 protein lingerer isoform X1 K26545 UBAP2; ubiquitin-associated protein 2
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
E 111506456 DNA mismatch repair protein Msh2 K08735 MSH2; DNA mismatch repair protein MSH2
E 111511219 probable DNA mismatch repair protein Msh6 K08737 MSH6; DNA mismatch repair protein MSH6
D MutL homologs
E 111503470 DNA mismatch repair protein Mlh1 isoform X1 K08734 MLH1; DNA mismatch repair protein MLH1
E 111505693 mismatch repair endonuclease PMS2 isoform X1 K10858 PMS2; DNA mismatch repair protein PMS2
E 111508326 uncharacterized protein LOC111508326 K08739 MLH3; DNA mismatch repair protein MLH3
D DNA polymerase delta complex
E 111505428 DNA polymerase delta catalytic subunit K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
E 111505042 DNA polymerase delta small subunit K02328 POLD2; DNA polymerase delta subunit 2
E 111505172 uncharacterized protein LOC111505172 isoform X1 K03504 POLD3; DNA polymerase delta subunit 3
D RPA (replication factor A)
E 111504718 replication protein A 70 kDa DNA-binding subunit K07466 RFA1; replication factor A1
E 111513952 replication protein A 32 kDa subunit K10739 RFA2; replication factor A2
E 111515205 uncharacterized protein LOC111515205 K10740 RPA3; replication factor A3
E 111509394 uncharacterized protein LOC111509394 K10740 RPA3; replication factor A3
D RFC (replication factor C)
E 111514426 replication factor C subunit 1 K10754 RFC1; replication factor C subunit 1
E 111503068 replication factor C subunit 2 K10755 RFC2_4; replication factor C subunit 2/4
E 111509755 replication factor C subunit 4 K10755 RFC2_4; replication factor C subunit 2/4
E 111502298 replication factor C subunit 5 isoform X1 K10756 RFC3_5; replication factor C subunit 3/5
E 111506565 replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
D Other MMR factors
E 111502554 proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
E 111505943 exonuclease 1 K10746 EXO1; exonuclease 1 [EC:3.1.-.-]
E 111501830 high mobility group protein DSP1 isoform X1 K10802 HMGB1; high mobility group protein B1
E 111509963 DNA ligase 1-like K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D MRN(MRX) complex
E 111507215 double-strand break repair protein MRE11 K10865 MRE11; double-strand break repair protein MRE11
E 111518122 DNA repair protein RAD50 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
E 111506391 nibrin K10867 NBN; nibrin
D BRCA1-core complex
D BRCA1-A complex
E 111506797 BRISC and BRCA1-A complex member 1-like K20776 BABAM; BRISC and BRCA1-A complex member 1
E 111517999 BRISC and BRCA1-A complex member 2-like K12173 BRE; BRCA1-A complex subunit BRE
E 111511593 lys-63-specific deubiquitinase BRCC36-like isoform X1 K11864 BRCC3; BRCA1/BRCA2-containing complex subunit 3 [EC:3.4.19.-]
E 111512471 lys-63-specific deubiquitinase BRCC36-like K11864 BRCC3; BRCA1/BRCA2-containing complex subunit 3 [EC:3.4.19.-]
D BRCA1-B complex
E 111509580 DNA topoisomerase 2-binding protein 1 isoform X1 K10728 TOPBP1; topoisomerase (DNA) II binding protein 1
D BRCA1-C complex
E 111507215 double-strand break repair protein MRE11 K10865 MRE11; double-strand break repair protein MRE11
E 111518122 DNA repair protein RAD50 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
E 111506391 nibrin K10867 NBN; nibrin
D BRCA complex
E 111513961 DNA repair protein RAD51 homolog 1 K04482 RAD51; DNA repair protein RAD51
D RecA family proteins
E 111513961 DNA repair protein RAD51 homolog 1 K04482 RAD51; DNA repair protein RAD51
E 111506076 DNA repair protein RAD51 homolog 4-like isoform X1 K10871 RAD51L3; RAD51-like protein 3
E 111507788 uncharacterized protein LOC111507788 K10879 XRCC2; DNA-repair protein XRCC2
E 111517186 DNA repair protein XRCC3-like K10880 XRCC3; DNA-repair protein XRCC3
D Rad52 family proteins
D Rad54 family proteins
E 111509636 DNA repair and recombination protein RAD54-like K10875 RAD54L; DNA repair and recombination protein RAD54 and RAD54-like protein [EC:5.6.2.-]
E 111505806 uncharacterized protein LOC111505806 K10876 RAD54L2; RAD54-like protein 2 [EC:5.6.2.-]
D RecQ family DNA helicases
E 111513694 ATP-dependent DNA helicase Q1-like K10899 RECQL; ATP-dependent DNA helicase Q1 [EC:5.6.2.4]
E 111518246 Werner syndrome ATP-dependent helicase-like K10900 WRN; werner syndrome ATP-dependent helicase [EC:5.6.2.4]
E 111518247 Werner syndrome ATP-dependent helicase-like K10900 WRN; werner syndrome ATP-dependent helicase [EC:5.6.2.4]
E 111505837 Bloom syndrome protein homolog K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 111501827 ATP-dependent DNA helicase Q4 K10730 RECQL4; ATP-dependent DNA helicase Q4 [EC:5.6.2.4]
E 111508417 ATP-dependent DNA helicase Q5-like K10902 RECQL5; ATP-dependent DNA helicase Q5 [EC:5.6.2.4]
D Bloom's syndrome complex (BTR)
E 111505837 Bloom syndrome protein homolog K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 111503110 DNA topoisomerase 3-alpha-like K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 111517749 DNA topoisomerase 3-beta-1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 111510435 recQ-mediated genome instability protein 1-like K10990 RMI1; RecQ-mediated genome instability protein 1
D RPA (replication factor A)
E 111504718 replication protein A 70 kDa DNA-binding subunit K07466 RFA1; replication factor A1
E 111513952 replication protein A 32 kDa subunit K10739 RFA2; replication factor A2
E 111515205 uncharacterized protein LOC111515205 K10740 RPA3; replication factor A3
E 111509394 uncharacterized protein LOC111509394 K10740 RPA3; replication factor A3
D Protein phosphatase 4
E 111501911 serine/threonine-protein phosphatase 4 catalytic subunit B K15423 PPP4C; serine/threonine-protein phosphatase 4 catalytic subunit [EC:3.1.3.16]
E 111507417 serine/threonine-protein phosphatase 4 regulatory subunit 1-like isoform X1 K15424 PPP4R1; serine/threonine-protein phosphatase 4 regulatory subunit 1
E 111503934 serine/threonine-protein phosphatase 4 regulatory subunit 2 K15425 PPP4R2; serine/threonine-protein phosphatase 4 regulatory subunit 2
E 111505849 serine/threonine-protein phosphatase 4 regulatory subunit 3 K17491 SMEK; protein phosphatase 4 regulatory subunit 3
E 111510113 serine/threonine-protein phosphatase 4 regulatory subunit 4-like isoform X1 K15426 PPP4R4; serine/threonine-protein phosphatase 4 regulatory subunit 4
D AP-5 complex
D SMC5-SMC6 complex
E 111514325 structural maintenance of chromosomes protein 5 K22803 SMC5; structural maintenance of chromosomes protein 5
E 111509298 structural maintenance of chromosomes protein 6 K22804 SMC6; structural maintenance of chromosomes protein 6
E 111501858 non-structural maintenance of chromosomes element 1 homolog K22817 NSMCE1; non-structural maintenance of chromosomes element 1 [EC:2.3.2.27]
E 111506494 E3 SUMO-protein ligase NSE2-like K22756 NSMCE2; E3 SUMO-protein ligase NSE2 [EC:2.3.2.-]
E 111513905 non-structural maintenance of chromosomes element 3 homolog K22823 NSMCE3; non-structural maintenance of chromosomes element 3
E 111502969 non-structural maintenance of chromosomes element 4 homolog A-like isoform X1 K22825 NSMCE4; non-structural maintenance of chromosomes element 4
D Other HR factors
E 111502576 crossover junction endonuclease MUS81 K08991 MUS81; crossover junction endonuclease MUS81 [EC:3.1.22.-]
E 111503936 DNA repair protein SWI5 homolog K10991 SWI5; DNA repair protein Swi5/Sae3
E 111504458 structure-specific endonuclease subunit slx1 K15078 SLX1; structure-specific endonuclease subunit SLX1 [EC:3.6.1.-]
E 111502352 flap endonuclease GEN isoform X1 K15338 GEN1; holliday junction resolvase GEN1/YEN1 [EC:3.1.-.-]
E 111515737 spatacsin K19026 SPG11; spatacsin
E 111505980 zinc finger FYVE domain-containing protein 26 homolog K19027 ZFYVE26; zinc finger FYVE domain-containing protein 26
E 111506414 mortality factor 4-like protein 1 K11339 MORF4L1; mortality factor 4-like protein 1
E 111503302 fidgetin-like protein 1 K22766 FIGNL1; fidgetin-like protein 1 [EC:5.6.2.-]
E 111511923 uncharacterized protein LOC111511923 K23112 BRAT1; BRCA1-associated ATM activator 1
E 111507428 uncharacterized protein LOC111507428 K23112 BRAT1; BRCA1-associated ATM activator 1
E 111505010 protein C21orf2 homolog isoform X1 K23456 CFAP410; cilla- and flagella-associated protein
E 111516295 BRCA2-interacting transcriptional repressor EMSY K25790 EMSY; BRCA2-interacting transcriptional repressor EMSY
E 111510584 protein MMS22-like K26125 MMS22L; protein MMS22-like
E 111517702 tonsoku-like protein K09257 NFKBIL2; NF-kappa-B inhibitor-like protein 2
E 111517281 biorientation of chromosomes in cell division protein 1-like 1 isoform X1 K27262 BOD1L1; biorientation of chromosomes in cell division protein 1-like 1
E 111514938 Werner Syndrome-like exonuclease K22807 WRNexo; werner syndrome-like exonuclease [EC:3.1.11.-]
C NHEJ (non-homologous end-joining)
D DNA-PK complex
E 111503835 uncharacterized protein LOC111503835 K10885 XRCC5; ATP-dependent DNA helicase 2 subunit 2
E 111504118 DNA-dependent protein kinase catalytic subunit-like K06642 PRKDC; DNA-dependent protein kinase catalytic subunit [EC:2.7.11.1]
D MRX complex
E 111507215 double-strand break repair protein MRE11 K10865 MRE11; double-strand break repair protein MRE11
E 111518122 DNA repair protein RAD50 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
D DNA Ligase 4 complex
E 111517919 DNA ligase 4 isoform X1 K10777 LIG4; DNA ligase 4 [EC:6.5.1.1]
E 111506262 DNA repair protein XRCC4-like K10886 XRCC4; DNA-repair protein XRCC4
E 111512590 uncharacterized protein LOC111512590 K10980 NHEJ1; non-homologous end-joining factor 1
D X-family DNA polymerases
E 111515323 DNA polymerase beta-like K02330 POLB; DNA polymerase beta [EC:2.7.7.7 4.2.99.-]
D Other NHEJ factors
E 111503849 aprataxin K10863 APTX; aprataxin [EC:3.6.1.70 3.6.1.71 3.6.1.72]
E 111517259 aprataxin and PNK-like factor K13295 APLF; aprataxin and PNK-like factor [EC:3.1.-.-]
E 111509927 aprataxin and PNK-like factor isoform X1 K13295 APLF; aprataxin and PNK-like factor [EC:3.1.-.-]
E 111509279 protein artemis K10887 DCLRE1C; DNA cross-link repair 1C protein [EC:3.1.-.-]
C FA (Fanconi anemia) pathway
D FA core complex
E 111504741 E3 ubiquitin-protein ligase FANCL-like K10606 FANCL; E3 ubiquitin-protein ligase FANCL [EC:2.3.2.27]
E 111508242 Fanconi anemia group M protein K10896 FANCM; fanconi anemia group M protein
D FA core complex binding factors
E 111503134 centromere protein S-like K11511 APITD1; centromere protein S
E 111507195 centromere protein X-like K15360 STRA13; centromere protein X
E 111518089 ubiquitin-conjugating enzyme E2 T-like K13960 UBE2T; ubiquitin-conjugating enzyme E2 T [EC:2.3.2.23]
D Bloom's syndrome complex (BTR)
E 111505837 Bloom syndrome protein homolog K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 111503110 DNA topoisomerase 3-alpha-like K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 111517749 DNA topoisomerase 3-beta-1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 111510435 recQ-mediated genome instability protein 1-like K10990 RMI1; RecQ-mediated genome instability protein 1
D FANCD2-I complex
E 111510016 Fanconi anemia group D2 protein K10891 FANCD2; fanconi anemia group D2 protein
E 111503223 Fanconi anemia group I protein homolog K10895 FANCI; fanconi anemia group I protein
D Downstream FA components
D Other FA pathway factors
E 111507289 fanconi-associated nuclease 1-like K15363 FAN1; fanconi-associated nuclease 1 [EC:3.1.21.- 3.1.4.1]
E 111513961 DNA repair protein RAD51 homolog 1 K04482 RAD51; DNA repair protein RAD51
E 111512877 ubiquitin carboxyl-terminal hydrolase 1 K11832 USP1; ubiquitin carboxyl-terminal hydrolase 1 [EC:3.4.19.12]
E 111518070 WD repeat-containing protein 48 homolog K15361 WDR48; WD repeat-containing protein 48
C Other DSBR factors
D Protein phosphatase 6
E 111513348 serine/threonine-protein phosphatase 6 catalytic subunit K15498 PPP6C; serine/threonine-protein phosphatase 6 catalytic subunit [EC:3.1.3.16]
E 111516324 serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X1 K15501 PPP6R3; serine/threonine-protein phosphatase 6 regulatory subunit 3
E 111503469 serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A-like isoform X1 K15502 ANKRD28; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A
D Ubiquitin ligases
E 111517455 E3 ubiquitin-protein ligase CHFR-like isoform X1 K10667 RNF8; E3 ubiquitin-protein ligase RNF8 [EC:2.3.2.27]
E 111506806 E3 ubiquitin-protein ligase rnf8-B-like K10667 RNF8; E3 ubiquitin-protein ligase RNF8 [EC:2.3.2.27]
E 111509983 E3 ubiquitin-protein ligase RNF168-like K20779 RNF168; E3 ubiquitin-protein ligase RNF168 [EC:2.3.2.31]
E 111504296 LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase HERC2-like K10595 HERC2; E3 ubiquitin-protein ligase HERC2 [EC:2.3.2.26]
D Others
E 111510566 telomerase Cajal body protein 1 K23314 WRAP53; telomerase Cajal body protein 1
E 111518087 zinc finger CW-type PWWP domain protein 1-like K24688 ZCWPW1; zinc finger CW-type PWWP domain protein 1
E 111505306 gastrulation defective protein 1 homolog K24752 WDR70; WD repeat-containing protein 70
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
D 111514504 DNA polymerase eta-like K03509 POLH; DNA polymerase eta [EC:2.7.7.7]
D 111514538 DNA polymerase eta-like K03509 POLH; DNA polymerase eta [EC:2.7.7.7]
D 111502892 DNA polymerase iota K03510 POLI; DNA polymerase iota [EC:2.7.7.7]
D 111505898 DNA repair protein REV1 K03515 REV1; DNA repair protein REV1 [EC:2.7.7.-]
C B-family DNA polymerases
D 111505083 DNA polymerase zeta catalytic subunit K02350 REV3L; DNA polymerase zeta [EC:2.7.7.7]
C A-family DNA polymerase
C Rad6 epistasis group
D 111508017 ubiquitin-conjugating enzyme E2-17 kDa K10573 UBE2A; ubiquitin-conjugating enzyme E2 A [EC:2.3.2.23]
D 111509327 ubiquitin-conjugating enzyme E2 variant 2 K10704 UBE2V; ubiquitin-conjugating enzyme E2 variant
D 111513510 ubiquitin-conjugating enzyme E2 N-like K10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23]
D 111506378 ubiquitin-conjugating enzyme E2 N K10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23]
C Other TLS factors
D 111502554 proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
D 111503660 sprT-like domain-containing protein Spartan K24051 SPRTN; SprT-like domain-contaning protein Spartan
D 111505345 uncharacterized protein LOC111505345 K26957 GCNA; germ cell nuclear acidic protein
B Check point factors
C Rad9-Hus1-Rad1 complex
D 111507671 cell cycle checkpoint control protein RAD9A-like K10995 RAD9B; cell cycle checkpoint control protein RAD9B
D 111505623 checkpoint protein HUS1 K10903 HUS1; HUS1 checkpoint protein
D 111508344 cell cycle checkpoint protein RAD1-like isoform X1 K02830 HRAD1; cell cycle checkpoint protein [EC:3.1.11.2]
C HRAD17(Rad24)-RFC complex
D 111515353 cell cycle checkpoint protein RAD17 K06662 HRAD17; cell cycle checkpoint protein
D 111503068 replication factor C subunit 2 K10755 RFC2_4; replication factor C subunit 2/4
D 111509755 replication factor C subunit 4 K10755 RFC2_4; replication factor C subunit 2/4
D 111502298 replication factor C subunit 5 isoform X1 K10756 RFC3_5; replication factor C subunit 3/5
D 111506565 replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
C Rad17-Mec3-Ddc1 complex
D 111508344 cell cycle checkpoint protein RAD1-like isoform X1 K02830 HRAD1; cell cycle checkpoint protein [EC:3.1.11.2]
C FPC (fork protection complex)
D 111505435 protein timeless homolog K10997 TIMELESS; replication fork protection complex subunit TIMELESS/Tof1/Swi1
D 111508996 TIMELESS-interacting protein K10998 TIPIN; replication fork protection complex subunit TIPIN/Csm3/Swi3
D 111506266 claspin-like isoform X1 K25773 CLSPN; claspin
C Triple T complex
D 111504227 TELO2-interacting protein 1 homolog K20403 TTI1; TELO2-interacting protein 1
C BAG6-UBL4A-GET4 complex
D 111512385 large proline-rich protein bag6 isoform X1 K23390 BAG6; large proline-rich protein BAG6
D 111517815 NEDD8 K23388 UBL4; ubiquitin-like protein 4
D 111505727 Golgi to ER traffic protein 4 homolog isoform X1 K23387 GET4; golgi to ER traffic protein 4
C Other check point factors
D 111506953 serine/threonine-protein kinase atr-like K06640 ATR; serine/threonine-protein kinase ATR [EC:2.7.11.1]
D 111504057 serine-protein kinase ATM K04728 ATM; serine-protein kinase ATM [EC:2.7.11.1]
D 111513532 serine/threonine-protein kinase grp K02216 CHEK1; serine/threonine-protein kinase CHEK1 [EC:2.7.11.1]
D 111515892 ovarian-specific serine/threonine-protein kinase Lok-like K06641 CHEK2; serine/threonine-protein kinase CHEK2 [EC:2.7.11.1]
D 111507285 ovarian-specific serine/threonine-protein kinase Lok-like K06641 CHEK2; serine/threonine-protein kinase CHEK2 [EC:2.7.11.1]
D 111505560 M-phase inducer phosphatase-like K05866 CDC25B; M-phase inducer phosphatase 2 [EC:3.1.3.48]
D 111506624 M-phase inducer phosphatase-like K05866 CDC25B; M-phase inducer phosphatase 2 [EC:3.1.3.48]
D 111516409 M-phase inducer phosphatase-like K05866 CDC25B; M-phase inducer phosphatase 2 [EC:3.1.3.48]
D 111516410 M-phase inducer phosphatase-like K05866 CDC25B; M-phase inducer phosphatase 2 [EC:3.1.3.48]
D 111516524 14-3-3 protein zeta K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
D 111517893 14-3-3 protein epsilon K06630 YWHAE; 14-3-3 protein epsilon
D 111509517 wee1-like protein kinase K06632 WEE1; wee1-like protein kinase [EC:2.7.11.1]
D 111502943 period circadian protein isoform X1 K02633 PER2; period circadian protein 2
D 111503521 formin-J-like K20780 MDC1; mediator of DNA damage checkpoint protein 1
D 111511928 plastin-3 K17336 PLS3; plastin-3
D 111505576 protein downstream neighbor of son homolog K22422 DONSON; protein downstream neighbor of Son
D 111504233 KN motif and ankyrin repeat domain-containing protein 2 isoform X1 K22808 KANK; KN motif and ankyrin repeat domain-containing protein
D 111504918 vacuolar protein sorting-associated protein 4B K12196 VPS4; vacuolar protein-sorting-associated protein 4
D 111513958 vacuolar protein sorting-associated protein 4B-like K12196 VPS4; vacuolar protein-sorting-associated protein 4
D 111513087 protein SDE2 homolog K25059 SDE2; replication stress response regulator SDE2
B Other factors with a suspected DNA repair function
C DNA polymerases
D 111506449 DNA polymerase theta isoform X1 K02349 POLQ; DNA polymerase theta [EC:2.7.7.7]
D 111502846 myb-binding protein 1A-like protein isoform X1 K02331 POL5; DNA polymerase phi [EC:2.7.7.7]
C Nucleases
D 111507507 three prime repair exonuclease 2-like K10790 TREX1; three prime repair exonuclease 1 [EC:3.1.11.2]
D 111509056 three-prime repair exonuclease 1-like K10790 TREX1; three prime repair exonuclease 1 [EC:3.1.11.2]
D 111510634 ankyrin repeat and LEM domain-containing protein 1-like K21411 ANKLE1; ankyrin repeat and LEM domain-containing protein 1
C Helicases
D 111511930 helicase POLQ-like K19178 HELQ; POLQ-like helicase [EC:5.6.2.4]
C PSO4 complex
D 111517083 pre-mRNA-processing factor 19 K10599 PRPF19; pre-mRNA-processing factor 19 [EC:2.3.2.27]
D 111506457 cell division cycle 5-like protein K12860 CDC5L; pre-mRNA-splicing factor CDC5/CEF1
D 111517130 pre-mRNA-splicing factor SPF27 K12861 BCAS2; pre-mRNA-splicing factor SPF27
D 111511622 pleiotropic regulator 1 K12862 PLRG1; pleiotropic regulator 1
C Modulation of nucleotide pools
D 111502829 8-oxo-dGDP phosphatase NUDT18 K17817 NUDT18; 8-oxo-dGDP phosphatase [EC:3.6.1.58]
D 111502916 deoxyuridine 5'-triphosphate nucleotidohydrolase-like K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 111504311 deoxyuridine 5'-triphosphate nucleotidohydrolase-like K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 111510796 ribonucleoside-diphosphate reductase large subunit K10807 RRM1; ribonucleoside-diphosphate reductase subunit M1 [EC:1.17.4.1]
D 111510799 ribonucleoside-diphosphate reductase large subunit-like K10807 RRM1; ribonucleoside-diphosphate reductase subunit M1 [EC:1.17.4.1]
D 111509986 ribonucleoside-diphosphate reductase subunit M2 B K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]
#
AProkaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D 111512992 deoxyribodipyrimidine photo-lyase-like K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]
C BER (base exicision repair)
D DNA glycosylases
E 111502451 uncharacterized protein LOC111502451 K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E 111505572 uncharacterized protein LOC111505572 K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E 111505574 uncharacterized protein LOC111505574 K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E 111518123 single-strand selective monofunctional uracil DNA glycosylase-like isoform X1 K10800 SMUG1; single-strand selective monofunctional uracil DNA glycosylase [EC:3.2.2.-]
E 111516486 probable DNA-3-methyladenine glycosylase K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]
E 111513827 endonuclease III-like protein 1 K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
D RecJ
D DNA ligase
D DNA polymerase I
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase complex (RNAP)
E TRCF (transcription-repair coupling factor)
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
D Molecular matchmaker
D Strand discrimination factor
D DNA exonucleases
D DNA polymerase III holoenzyme
D DNA ligase
D Other MMR factors
E 111512820 single-stranded DNA-binding protein, mitochondrial isoform X1 K03111 ssb; single-strand DNA-binding protein
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D RecBC pathway proteins
D RecFOR pathway proteins
D AddAB pathway proteins
D Other HR factor
D Archaeal homologous recombinant proteins
C NHEJ (non-homologous end-joining)
D Two-component NHEJ DNA repair complex
D SHIIR (short-homology-independent illegitimate recombination)
E Facilitator
E Supressor
D SHDIR (short-homology-dependent illegitimate recombination)
E RecET pathway
E Facilitator
E Supressor
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
C Other SOS response factors
D 111512820 single-stranded DNA-binding protein, mitochondrial isoform X1 K03111 ssb; single-strand DNA-binding protein
B Other factors with a suspected DNA repair function
C DNA polymerase
C DNA helicases
C Modulation of nucleotide pools
D 111502916 deoxyuridine 5'-triphosphate nucleotidohydrolase-like K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 111504311 deoxyuridine 5'-triphosphate nucleotidohydrolase-like K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
C Others
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#
#[ BRITE | KEGG2 | KEGG ]
#Last updated: March 29, 2024