+F Repair protein KO
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DNA Repair and Recombination Proteins - Lysobacter enzymogenes M497-1
%
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AEukaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D LEN_3586 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
D LEN_2402 phrB; deoxyribodipyrimidine photolyase K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]
C BER (base exicision repair)
D DNA glycosylases
E LEN_4548 ung; uracil-DNA glycosylase K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E LEN_1601 mutY; A/G-specific adenine glycosylase K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
E LEN_1784 nth; endonuclease III K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
D Long Patch-BER factors
E DNA polymerase delta complex
E DNA polymerase epsilon complex
D Short Patch-BER factors
D Other BER factors
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E XPC-HR23B-CETN2 complex
E Cul4-DDB2 complex
E NER4 complex
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase II complex
E Cul4-CSA complex
E Other TCR factor
D TFIIH complex
D RPA (replication factor A)
D Other NER factors
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
D MutL homologs
D DNA polymerase delta complex
D RPA (replication factor A)
D RFC (replication factor C)
D Other MMR factors
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D MRN(MRX) complex
D BRCA1-core complex
D BRCA1-A complex
D BRCA1-B complex
D BRCA1-C complex
D BRCA complex
D RecA family proteins
D Rad52 family proteins
D Rad54 family proteins
D RecQ family DNA helicases
D Bloom's syndrome complex (BTR)
D RPA (replication factor A)
D Protein phosphatase 4
D AP-5 complex
D SMC5-SMC6 complex
D Other HR factors
C NHEJ (non-homologous end-joining)
D DNA-PK complex
D MRX complex
D DNA Ligase 4 complex
D X-family DNA polymerases
D Other NHEJ factors
C FA (Fanconi anemia) pathway
D FA core complex
D FA core complex binding factors
D Bloom's syndrome complex (BTR)
D FANCD2-I complex
D Downstream FA components
D Other FA pathway factors
C Other DSBR factors
D Protein phosphatase 6
D Ubiquitin ligases
D Others
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
C B-family DNA polymerases
C A-family DNA polymerase
C Rad6 epistasis group
C Other TLS factors
B Check point factors
C Rad9-Hus1-Rad1 complex
C HRAD17(Rad24)-RFC complex
C Rad17-Mec3-Ddc1 complex
C FPC (fork protection complex)
C Triple T complex
C BAG6-UBL4A-GET4 complex
C Other check point factors
B Other factors with a suspected DNA repair function
C DNA polymerases
C Nucleases
D LEN_3988 endonuclease K05986 NUCS; nuclease S1 [EC:3.1.30.1]
C Helicases
C PSO4 complex
C Modulation of nucleotide pools
D LEN_1073 conserved hypothetical protein K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D LEN_3507 7,8-dihydro-8-oxoguanine-triphosphatase K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D LEN_0969 ATP/GTP-binding protein K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D LEN_1546 NUDIX hydrolase K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D LEN_4689 dut; dUTP pyrophosphatase K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
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AProkaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D LEN_3586 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
D LEN_0751 ada; AraC family transcriptional regulator, regulatory protein of adaptative response/methylated-DNA-[protein]-cysteine methyltransferase K10778 ada; AraC family transcriptional regulator, regulatory protein of adaptative response / methylated-DNA-[protein]-cysteine methyltransferase [EC:2.1.1.63]
D LEN_2402 phrB; deoxyribodipyrimidine photolyase K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]
C BER (base exicision repair)
D DNA glycosylases
E LEN_4548 ung; uracil-DNA glycosylase K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E LEN_2883 conserved hypothetical protein K03649 mug; double-stranded uracil-DNA glycosylase [EC:3.2.2.28]
E LEN_3380 DNA-3-methyladenine glycosylase II K01247 alkA; DNA-3-methyladenine glycosylase II [EC:3.2.2.21]
E LEN_3585 alkA; AraC family transcriptional regulator, regulatory protein of adaptative response/DNA-3-methyladenine glycosylase II K13529 ada-alkA; AraC family transcriptional regulator, regulatory protein of adaptative response / DNA-3-methyladenine glycosylase II [EC:3.2.2.21]
E LEN_1601 mutY; A/G-specific adenine glycosylase K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
E LEN_3740 tagA; DNA-3-methyladenine glycosylase I K01246 tag; DNA-3-methyladenine glycosylase I [EC:3.2.2.20]
E LEN_0357 mutM; formamidopyrimidine-DNA glycosylase K10563 mutM; formamidopyrimidine-DNA glycosylase [EC:3.2.2.23 4.2.99.18]
E LEN_2445 nei; DNA-formamidopyrimidine glycosylase K05522 nei; endonuclease VIII [EC:3.2.2.- 4.2.99.18]
E LEN_1784 nth; endonuclease III K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
E LEN_4684 exodeoxyribonuclease III K01142 E3.1.11.2; exodeoxyribonuclease III [EC:3.1.11.2]
E LEN_4767 xthA; exodeoxyribonuclease III K01142 E3.1.11.2; exodeoxyribonuclease III [EC:3.1.11.2]
E LEN_0766 conserved hypothetical protein K05982 E3.1.21.7; deoxyribonuclease V [EC:3.1.21.7]
D RecJ
E LEN_2805 recJ; single-stranded-DNA-specific exonuclease RecJ K07462 recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-]
D DNA ligase
E LEN_2273 ligA; DNA ligase (NAD+) K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
D DNA polymerase I
E LEN_4568 polA; DNA polymerase I K02335 polA; DNA polymerase I [EC:2.7.7.7]
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E LEN_1797 uvrA; excinuclease ABC subunit A K03701 uvrA; excinuclease ABC subunit A
E LEN_2541 conserved hypothetical protein K03701 uvrA; excinuclease ABC subunit A
E LEN_1554 uvrB; excinuclease ABC subunit B K03702 uvrB; excinuclease ABC subunit B
E LEN_2006 uvrC; excinuclease ABC subunit C K03703 uvrC; excinuclease ABC subunit C
E LEN_4574 uvrD; DNA-dependent helicase II K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E LEN_3938 conserved hypothetical protein K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E LEN_4568 polA; DNA polymerase I K02335 polA; DNA polymerase I [EC:2.7.7.7]
E LEN_2273 ligA; DNA ligase (NAD+) K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase complex (RNAP)
F LEN_1346 rpoB; DNA-directed RNA polymerase subunit beta K03043 rpoB; DNA-directed RNA polymerase subunit beta [EC:2.7.7.6]
F LEN_1347 rpoC; DNA-directed RNA polymerase subunit beta' K03046 rpoC; DNA-directed RNA polymerase subunit beta' [EC:2.7.7.6]
F LEN_1377 rpoA; DNA-directed RNA polymerase subunit alpha K03040 rpoA; DNA-directed RNA polymerase subunit alpha [EC:2.7.7.6]
F LEN_4049 rpoZ; DNA-directed RNA polymerase subunit omega K03060 rpoZ; DNA-directed RNA polymerase subunit omega [EC:2.7.7.6]
E TRCF (transcription-repair coupling factor)
F LEN_3345 mfd; transcription-repair coupling factor K03723 mfd; transcription-repair coupling factor (superfamily II helicase) [EC:5.6.2.4]
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
E LEN_1843 DNA mismatch repair protein MutS K03555 mutS; DNA mismatch repair protein MutS
D Molecular matchmaker
E LEN_1890 DNA mismatch repair protein MutL K03572 mutL; DNA mismatch repair protein MutL
D Strand discrimination factor
D DNA exonucleases
E LEN_2354 exodeoxyribonuclease I K01141 sbcB; exodeoxyribonuclease I [EC:3.1.11.1]
E LEN_3231 xseA; exodeoxyribonuclease VII large subunit K03601 xseA; exodeoxyribonuclease VII large subunit [EC:3.1.11.6]
E LEN_1721 xseB; exodeoxyribonuclease VII small subunit K03602 xseB; exodeoxyribonuclease VII small subunit [EC:3.1.11.6]
D DNA polymerase III holoenzyme
E LEN_1727 dnaE; DNA polymerase III subunit alpha K02337 dnaE; DNA polymerase III subunit alpha [EC:2.7.7.7]
E LEN_0002 dnaN; DNA polymerase III subunit beta K02338 dnaN; DNA polymerase III subunit beta [EC:2.7.7.7]
E LEN_0997 holC; DNA polymerase III subunit chi K02339 holC; DNA polymerase III subunit chi [EC:2.7.7.7]
E LEN_1686 holA; DNA polymerase III subunit delta K02340 holA; DNA polymerase III subunit delta [EC:2.7.7.7]
E LEN_3267 holB; DNA polymerase III subunit delta' K02341 holB; DNA polymerase III subunit delta' [EC:2.7.7.7]
E LEN_3306 dnaQ; DNA polymerase III subunit epsilon K02342 dnaQ; DNA polymerase III subunit epsilon [EC:2.7.7.7]
E LEN_3291 dnaZX; DNA polymerase III subunits gamma and tau K02343 dnaX; DNA polymerase III subunit gamma/tau [EC:2.7.7.7]
D DNA ligase
E LEN_2273 ligA; DNA ligase (NAD+) K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
D Other MMR factors
E LEN_4574 uvrD; DNA-dependent helicase II K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E LEN_3938 conserved hypothetical protein K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E LEN_1414 single-strand DNA-binding protein K03111 ssb; single-strand DNA-binding protein
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D RecBC pathway proteins
E LEN_0087 recC; exodeoxyribonuclease V beta subunit K03582 recB; exodeoxyribonuclease V beta subunit [EC:3.1.11.5]
E LEN_0086 recB; exodeoxyribonuclease V subunit gamma K03583 recC; exodeoxyribonuclease V gamma subunit [EC:3.1.11.5]
E LEN_0088 recD; exodeoxyribonuclease V alpha subunit K03581 recD; exodeoxyribonuclease V alpha subunit [EC:3.1.11.5]
E LEN_1859 recA; recombination protein RecA K03553 recA; recombination protein RecA
E LEN_1139 ruvA; Holliday junction DNA helicase RuvA K03550 ruvA; holliday junction DNA helicase RuvA
E LEN_1143 ruvB; Holliday junction DNA helicase RuvB K03551 ruvB; holliday junction DNA helicase RuvB [EC:5.6.2.4]
E LEN_1138 ruvC; crossover junction endodeoxyribonuclease RuvC K01159 ruvC; crossover junction endodeoxyribonuclease RuvC [EC:3.1.21.10]
E LEN_4509 priA; primosomal protein N' K04066 priA; primosomal protein N' (replication factor Y) (superfamily II helicase) [EC:5.6.2.4]
E LEN_2354 exodeoxyribonuclease I K01141 sbcB; exodeoxyribonuclease I [EC:3.1.11.1]
D RecFOR pathway proteins
E LEN_1859 recA; recombination protein RecA K03553 recA; recombination protein RecA
E LEN_1814 radA; DNA repair protein RadA/Sms K04485 radA; DNA repair protein RadA/Sms
E LEN_0003 recF; DNA replication and repair protein RecF K03629 recF; DNA replication and repair protein RecF
E LEN_4040 recG; ATP-dependent DNA helicase RecG K03655 recG; ATP-dependent DNA helicase RecG [EC:5.6.2.4]
E LEN_2805 recJ; single-stranded-DNA-specific exonuclease RecJ K07462 recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-]
E LEN_3256 DNA repair protein RecO K03584 recO; DNA repair protein RecO (recombination protein O)
E LEN_3288 recR; recombination protein RecR K06187 recR; recombination protein RecR
E LEN_2818 recN; DNA repair protein RecN K03631 recN; DNA repair protein RecN (Recombination protein N)
E LEN_0337 recombination associated protein RdgC K03554 rdgC; recombination associated protein RdgC
E LEN_1139 ruvA; Holliday junction DNA helicase RuvA K03550 ruvA; holliday junction DNA helicase RuvA
E LEN_1143 ruvB; Holliday junction DNA helicase RuvB K03551 ruvB; holliday junction DNA helicase RuvB [EC:5.6.2.4]
E LEN_1138 ruvC; crossover junction endodeoxyribonuclease RuvC K01159 ruvC; crossover junction endodeoxyribonuclease RuvC [EC:3.1.21.10]
D AddAB pathway proteins
D Other HR factor
D Archaeal homologous recombinant proteins
E LEN_2904 conserved hypothetical protein K06915 herA; DNA double-strand break repair helicase HerA and related ATPase
C NHEJ (non-homologous end-joining)
D Two-component NHEJ DNA repair complex
D SHIIR (short-homology-independent illegitimate recombination)
E Facilitator
F LEN_2279 gyrA; DNA gyrase subunit A K02469 gyrA; DNA gyrase subunit A [EC:5.6.2.2]
F LEN_0005 gyrB; DNA gyrase subunit B K02470 gyrB; DNA gyrase subunit B [EC:5.6.2.2]
F LEN_4495 topA; DNA topoisomerase I K03168 topA; DNA topoisomerase I [EC:5.6.2.1]
F LEN_2632 conserved hypothetical protein K03168 topA; DNA topoisomerase I [EC:5.6.2.1]
E Supressor
F LEN_1702 hupB; DNA-binding protein HU-beta K03530 hupB; DNA-binding protein HU-beta
D SHDIR (short-homology-dependent illegitimate recombination)
E RecET pathway
F LEN_2805 recJ; single-stranded-DNA-specific exonuclease RecJ K07462 recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-]
F LEN_3256 DNA repair protein RecO K03584 recO; DNA repair protein RecO (recombination protein O)
F LEN_3288 recR; recombination protein RecR K06187 recR; recombination protein RecR
F LEN_2273 ligA; DNA ligase (NAD+) K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
E Facilitator
F LEN_4186 Fis family transcriptional regulator, factor for inversion stimulation protein K03557 fis; Fis family transcriptional regulator, factor for inversion stimulation protein
F LEN_1569 integration host factor subunit alpha K04764 ihfA; integration host factor subunit alpha
F LEN_2106 integration host factor subunit beta K05788 ihfB; integration host factor subunit beta
E Supressor
F LEN_2354 exodeoxyribonuclease I K01141 sbcB; exodeoxyribonuclease I [EC:3.1.11.1]
F LEN_1182 recQ; ATP-dependent DNA helicase RecQ K03654 recQ; ATP-dependent DNA helicase RecQ [EC:5.6.2.4]
F LEN_1797 uvrA; excinuclease ABC subunit A K03701 uvrA; excinuclease ABC subunit A
F LEN_2541 conserved hypothetical protein K03701 uvrA; excinuclease ABC subunit A
F LEN_1554 uvrB; excinuclease ABC subunit B K03702 uvrB; excinuclease ABC subunit B
F LEN_0989 DNA-binding protein K03746 hns; DNA-binding protein H-NS
F LEN_4450 DNA-binding protein HNS K03746 hns; DNA-binding protein H-NS
F LEN_0247 conserved hypothetical protein K03746 hns; DNA-binding protein H-NS
F LEN_3936 conserved hypothetical protein K03746 hns; DNA-binding protein H-NS
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
D LEN_0044 dinB; DNA polymerase IV K02346 dinB; DNA polymerase IV [EC:2.7.7.7]
D LEN_4078 DNA-directed DNA polymerase K02346 dinB; DNA polymerase IV [EC:2.7.7.7]
C Other SOS response factors
D LEN_1859 recA; recombination protein RecA K03553 recA; recombination protein RecA
D LEN_1857 lexA; repressor LexA K01356 lexA; repressor LexA [EC:3.4.21.88]
D LEN_2841 repressor LexA K01356 lexA; repressor LexA [EC:3.4.21.88]
D LEN_2818 recN; DNA repair protein RecN K03631 recN; DNA repair protein RecN (Recombination protein N)
D LEN_2842 conserved hypothetical protein K14160 imuA; protein ImuA
D LEN_2843 conserved hypothetical protein K14161 imuB; protein ImuB
D LEN_2844 dnaE2; error-prone DNA polymerase K14162 dnaE2; error-prone DNA polymerase [EC:2.7.7.7]
D LEN_1414 single-strand DNA-binding protein K03111 ssb; single-strand DNA-binding protein
D LEN_1860 conserved hypothetical protein K03565 recX; regulatory protein
B Other factors with a suspected DNA repair function
C DNA polymerase
C DNA helicases
D LEN_0313 rep; ATP-dependent DNA helicase Rep K03656 rep; ATP-dependent DNA helicase Rep [EC:5.6.2.4]
D LEN_3923 helD; DNA helicase IV K03658 helD; DNA helicase IV [EC:5.6.2.4]
D LEN_1192 dinG; ATP-dependent DNA helicase DinG K03722 dinG; ATP-dependent DNA helicase DinG [EC:5.6.2.3]
D LEN_2697 lhr; ATP-dependent helicase Lhr and Lhr-like helicase K03724 lhr; ATP-dependent helicase Lhr and Lhr-like helicase [EC:5.6.2.6 5.6.2.4]
C Modulation of nucleotide pools
D LEN_1073 conserved hypothetical protein K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D LEN_3507 7,8-dihydro-8-oxoguanine-triphosphatase K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D LEN_0969 ATP/GTP-binding protein K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D LEN_1546 NUDIX hydrolase K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D LEN_4689 dut; dUTP pyrophosphatase K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D LEN_3978 nrdL; ribonucleoside-diphosphate reductase subunit M1 K00525 E1.17.4.1A; ribonucleoside-diphosphate reductase alpha chain [EC:1.17.4.1]
D LEN_0772 ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent K00525 E1.17.4.1A; ribonucleoside-diphosphate reductase alpha chain [EC:1.17.4.1]
D LEN_4305 conserved hypothetical protein K00525 E1.17.4.1A; ribonucleoside-diphosphate reductase alpha chain [EC:1.17.4.1]
D LEN_3979 nrdM; ribonucleoside-diphosphate reductase subunit M2 K00526 E1.17.4.1B; ribonucleoside-diphosphate reductase beta chain [EC:1.17.4.1]
C Others
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: August 19, 2024